octinoxate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4236 | 5466-77-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
a UV filter compound
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 7, 1992 | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Squamous cell carcinoma of skin | 185.60 | 27.69 | 35 | 610 | 5143 | 50599336 |
| Skin atrophy | 104.59 | 27.69 | 21 | 624 | 4224 | 50600255 |
| Neoplasm skin | 83.64 | 27.69 | 14 | 631 | 1026 | 50603453 |
| Ochronosis | 61.08 | 27.69 | 7 | 638 | 26 | 50604453 |
| Product use in unapproved indication | 39.24 | 27.69 | 22 | 623 | 115797 | 50488682 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Squamous cell carcinoma of skin | 173.42 | 27.19 | 37 | 665 | 11839 | 64486191 |
| Skin atrophy | 104.78 | 27.19 | 21 | 681 | 4899 | 64493131 |
| Neoplasm skin | 83.87 | 27.19 | 14 | 688 | 1183 | 64496847 |
| Ochronosis | 59.85 | 27.19 | 7 | 695 | 39 | 64497991 |
| Product use in unapproved indication | 33.84 | 27.19 | 22 | 680 | 176596 | 64321434 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D02BA02 | DERMATOLOGICALS EMOLLIENTS AND PROTECTIVES PROTECTIVES AGAINST UV-RADIATION Protectives against UV-radiation for topical use |
| MeSH PA | D003358 | Cosmetics |
| MeSH PA | D003879 | Dermatologic Agents |
| MeSH PA | D020011 | Protective Agents |
| MeSH PA | D011837 | Radiation-Protective Agents |
| MeSH PA | D013473 | Sunscreening Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Discoloration of skin | indication | 3253007 | |
| Chloasma | indication | 36209000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4Y5P7MUD51 | UNII |
| 4025697 | VUID |
| N0000179014 | NUI |
| D05225 | KEGG_DRUG |
| 4020294 | VANDF |
| 4020377 | VANDF |
| 4020661 | VANDF |
| 4025697 | VANDF |
| C0046100 | UMLSCUI |
| CHEBI:134750 | CHEBI |
| CHEMBL3183184 | ChEMBL_ID |
| CHEMBL1200608 | ChEMBL_ID |
| 5355130 | PUBCHEM_CID |
| DB09496 | DRUGBANK_ID |
| 7945 | INN_ID |
| C118580 | MESH_SUPPLEMENTAL_RECORD_UI |
| C516303 | MESH_SUPPLEMENTAL_RECORD_UI |
| 13369 | RXNORM |
| 003659 | NDDF |
| 007440 | NDDF |
| 255902000 | SNOMEDCT_US |
| 411144000 | SNOMEDCT_US |
| 83834-59-7 | SECONDARY_CAS_RN |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen | HUMAN OTC DRUG LABEL | 3 | 0023-5494 | LOTION | 75 mg | TOPICAL | OTC monograph not final | 12 sections |
| TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen (Tinted) | HUMAN OTC DRUG LABEL | 4 | 0023-5497 | LOTION | 75 mg | TOPICAL | OTC monograph not final | 12 sections |
| TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 50 Sunscreen | HUMAN OTC DRUG LABEL | 4 | 0023-5501 | LOTION | 75 mg | TOPICAL | OTC monograph not final | 8 sections |
| Essential Defense Everyday Clear Broad Spectrum SPF 47 Sunscreen | HUMAN OTC DRUG LABEL | 2 | 0023-5738 | LOTION | 75 mg | TOPICAL | OTC monograph not final | 8 sections |
| Solbar Thirty SPF 30 | HUMAN OTC DRUG LABEL | 5 | 0096-0685 | CREAM | 0.08 g | TOPICAL | OTC monograph final | 8 sections |
| Solbar Avo SPF35 | HUMAN OTC DRUG LABEL | 4 | 0096-0687 | CREAM | 0.08 g | TOPICAL | OTC monograph final | 8 sections |
| Solbar Zinc SPF38 | HUMAN OTC DRUG LABEL | 3 | 0096-0688 | CREAM | 0.08 1 | TOPICAL | OTC monograph final | 8 sections |
| Daily Facial MoisturizerSPF 25 | HUMAN OTC DRUG LABEL | 4 | 0096-0721 | CREAM | 0.08 g | TOPICAL | OTC monograph final | 11 sections |
| Solbar Fifty SPF50 | HUMAN OTC DRUG LABEL | 4 | 0096-0741 | CREAM | 0.08 g | TOPICAL | OTC monograph final | 8 sections |
| Purpose | HUMAN OTC DRUG LABEL | 3 | 0187-5500 | LOTION | 76 mg | TOPICAL | OTC monograph not final | 9 sections |
| Cetaphil Daily Facial Moisturizer with suncreen SPF 50 | HUMAN OTC DRUG LABEL | 5 | 0299-4930 | LOTION | 75 mg | TOPICAL | OTC monograph final | 11 sections |
| Cetaphil Daily Facial Moisturizer with suncreen SPF 50 | HUMAN OTC DRUG LABEL | 5 | 0299-4930 | LOTION | 75 mg | TOPICAL | OTC monograph final | 11 sections |
| Almay Wake-Up Liquid Make-Up | HUMAN OTC DRUG LABEL | 2 | 0311-0704 | LIQUID | 3.50 mg | TOPICAL | OTC monograph final | 8 sections |
| Almay Smart Shade CC Cream | HUMAN OTC DRUG LABEL | 3 | 0311-0705 | LIQUID | 7.50 mg | TOPICAL | OTC monograph final | 6 sections |
| Almay Age Essentials Makeup SPF 15 | HUMAN OTC DRUG LABEL | 2 | 0311-0707 | LIQUID | 3.50 mg | TOPICAL | OTC monograph final | 8 sections |
| Almay Age Essentials Concealer SPF 20 | HUMAN OTC DRUG LABEL | 2 | 0311-0708 | LIQUID | 7.50 mg | TOPICAL | OTC monograph final | 8 sections |
| Almay Anti Aging Lip Care SPF 20 | HUMAN OTC DRUG LABEL | 5 | 0311-0709 | LIPSTICK | 7.50 mg | TOPICAL | OTC monograph final | 8 sections |
| Almay Best Blend Forever Makeup | HUMAN OTC DRUG LABEL | 4 | 0311-0719 | LOTION | 7.50 mg | TOPICAL | OTC monograph final | 5 sections |
| Blue Lizard Regular | HUMAN OTC DRUG LABEL | 4 | 0316-2010 | LOTION | 76.50 mg | TOPICAL | OTC monograph final | 8 sections |
| Blue Lizard Sport Original Sunscreen | HUMAN OTC DRUG LABEL | 4 | 0316-2019 | LOTION | 76.50 mg | TOPICAL | OTC monograph not final | 8 sections |
| Blue Lizard Face | HUMAN OTC DRUG LABEL | 2 | 0316-2055 | GEL | 55 mg | TOPICAL | OTC monograph not final | 8 sections |
| Walgreens Anti-Sagging and Ultra Hydrating Day Cream Broad Spectrum SPF15 Sunscreen | HUMAN OTC DRUG LABEL | 3 | 0363-0696 | CREAM | 10 g | TOPICAL | OTC monograph not final | 12 sections |
| WALGREENS BROAD SPECTRUM SPF 30 DRY TOUCH SUNSCREEN | HUMAN OTC DRUG LABEL | 5 | 0363-0940 | LOTION | 75 mg | TOPICAL | OTC monograph not final | 13 sections |
| Creal Zink Sunscreen SPF 50Well at Walgreens | HUMAN OTC DRUG LABEL | 3 | 0363-1117 | STICK | 7.50 g | TOPICAL | OTC monograph not final | 7 sections |
| Walgreens SunscreenSPF 15 | HUMAN OTC DRUG LABEL | 2 | 0363-4001 | LOTION | 7.50 g | TOPICAL | OTC monograph not final | 10 sections |
| Walgreens Dark Tanning Oil SunscreenSPF 4 | HUMAN OTC DRUG LABEL | 1 | 0363-4004 | SPRAY | 3 g | TOPICAL | OTC monograph not final | 10 sections |
| Walgreens SunscreenSPF 45 SPF 45 SPF 45 | HUMAN OTC DRUG LABEL | 3 | 0363-4008 | LOTION | 7.50 g | TOPICAL | OTC monograph not final | 10 sections |
| Walgreens Chap Aid Moisturizer | HUMAN OTC DRUG LABEL | 3 | 0363-8190 | STICK | 75 mg | TOPICAL | OTC monograph final | 9 sections |
| Chapstick Moisturizer Original | HUMAN OTC DRUG LABEL | 3 | 0573-0725 | STICK | 75 mg | TOPICAL | OTC MONOGRAPH FINAL | 14 sections |
| Chapstick Moisturizer Green Apple | HUMAN OTC DRUG LABEL | 3 | 0573-0728 | STICK | 75 mg | TOPICAL | OTC MONOGRAPH FINAL | 14 sections |