mequinol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4221 150-76-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mequinol
  • p-Hydroxyanisol
  • hydroquinone methyl ether
  • p-Hydroxymethoxybenzene
depigmenting agent; RN given refers to parent cpd
  • Molecular weight: 124.14
  • Formula: C7H8O2
  • CLOGP: 1.57
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 29.46
  • ALOGS: -0.54
  • ROTB: 1

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 10, 1999 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D11AX06 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Other dermatologicals
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000975 Antioxidants
MeSH PA D020011 Protective Agents
FDA MoA N0000175850 Melanin Synthesis Inhibitors
FDA PE N0000175851 Depigmenting Activity
FDA EPC N0000175855 Skin Lightening Agent
CHEBI has role CHEBI:25212 metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Solar Lentigines indication
Sunburn contraindication 23346002
Eczema contraindication 43116000
Vitiligo contraindication 56727007 DOID:12306
Pregnancy, function contraindication 289908002
Breastfeeding (mother) contraindication 413712001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.15 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Tyrosinase Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
4025437 VUID
N0000179021 NUI
D04926 KEGG_DRUG
4025437 VANDF
C0048318 UMLSCUI
CHEBI:69441 CHEBI
4KS PDB_CHEM_ID
CHEMBL544 ChEMBL_ID
DB09516 DRUGBANK_ID
C009760 MESH_SUPPLEMENTAL_RECORD_UI
6827 IUPHAR_LIGAND_ID
1542 INN_ID
6HT8U7K3AM UNII
9015 PUBCHEM_CID
15080 RXNORM
8732 MMSL
005329 NDDF
398927001 SNOMEDCT_US
422343004 SNOMEDCT_US

Pharmaceutical products:

None