sodium phosphate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4219	7558-79-4

Description:

Molecule	Description
Synonyms: sodium phosphate, monobasic anhydrous disodium phosphate sodium phosphate sodium phosphate, dibasic, heptahydrate sodium phosphate, dibasic sodium phosphate, dibasic anhydrous sodium phosphate, monobasic, anhydrous	Molecular weight: 141.96 Formula: HNa2O4P CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 83.42 ALOGS: ROTB: None

Molecule

Description

Synonyms:

sodium phosphate, monobasic anhydrous
disodium phosphate
sodium phosphate
sodium phosphate, dibasic, heptahydrate
sodium phosphate, dibasic
sodium phosphate, dibasic anhydrous
sodium phosphate, monobasic, anhydrous

Molecular weight: 141.96
Formula: HNa2O4P
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 83.42
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
50	g	O
8	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
May 10, 1983	FDA	HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Intestinal pseudo-obstruction	75.04	15.38	17	5284	895	63482826
Cytokine release syndrome	40.42	15.38	21	5280	14293	63469428
Acute phosphate nephropathy	34.55	15.38	5	5296	17	63483704
Loss of bladder sensation	29.62	15.38	5	5296	54	63483667
Diarrhoea	27.45	15.38	125	5176	715241	62768480
Food refusal	25.57	15.38	6	5295	369	63483352
Mutism	24.73	15.38	8	5293	1622	63482099
Neutropenic sepsis	24.69	15.38	16	5285	16422	63467299
Cholelithiasis	22.93	15.38	23	5278	43902	63439819
Hypokalaemia	22.59	15.38	35	5266	103769	63379952
Back pain	22.24	15.38	60	5241	264085	63219636
Urinary tract infection	22.16	15.38	60	5241	264624	63219097
Delirium	21.98	15.38	24	5277	50517	63433204
Encephalopathy	19.75	15.38	20	5281	38600	63445121
Febrile neutropenia	19.18	15.38	35	5266	118414	63365307
Vomiting	17.94	15.38	93	5208	559524	62924197
Product compounding quality issue	17.89	15.38	3	5298	31	63483690
Blood phosphorus decreased	16.93	15.38	8	5293	4445	63479276
Hypophosphataemia	16.86	15.38	11	5290	11415	63472306
Anaemia	16.59	15.38	58	5243	293372	63190349
Urinary retention	16.06	15.38	16	5285	30285	63453436

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	147.76	19.66	52	4610	8549	34943720
Appendicitis	123.62	19.66	53	4609	14754	34937515
Aplastic anaemia	116.14	19.66	45	4617	9671	34942598
Cardiogenic shock	96.82	19.66	54	4608	26564	34925705
Stress	87.64	19.66	53	4609	30294	34921975
Ventricular fibrillation	81.91	19.66	46	4616	22908	34929361
Ascites	75.84	19.66	57	4605	46514	34905755
Abdominal distension	74.64	19.66	62	4600	58430	34893839
Blood phosphorus increased	62.30	19.66	27	4635	7694	34944575
Lymphocyte count decreased	61.42	19.66	38	4624	22584	34929685
Hyponatraemia	54.63	19.66	61	4601	82630	34869639
Sepsis	53.07	19.66	86	4576	166475	34785794
Multiple organ dysfunction syndrome	51.46	19.66	57	4605	76509	34875760
Abdominal pain	50.11	19.66	83	4579	163535	34788734
Hypogonadism	47.91	19.66	16	4646	2239	34950030
Myasthenia gravis	39.38	19.66	19	4643	6921	34945348
Cytokine release syndrome	37.19	19.66	28	4634	22849	34929420
Vomiting	36.70	19.66	93	4569	247528	34704741
Red blood cells urine positive	35.14	19.66	12	4650	1797	34950472
Incision site pain	34.95	19.66	12	4650	1826	34950443
Dry mouth	34.37	19.66	30	4632	30135	34922134
Blood uric acid increased	33.52	19.66	19	4643	9605	34942664
General physical health deterioration	32.60	19.66	60	4602	128209	34824060
Mucosal inflammation	26.33	19.66	29	4633	38593	34913676
Protein urine present	25.75	19.66	13	4649	5215	34947054
Blood cholesterol increased	22.53	19.66	20	4642	20523	34931746
Nausea	21.64	19.66	96	4566	339812	34612457
Neutrophil count increased	21.45	19.66	18	4644	17128	34935141
Blood urea increased	21.04	19.66	23	4639	30341	34921928
Procedural pain	20.92	19.66	11	4651	4795	34947474
Blood albumin decreased	20.70	19.66	16	4646	13556	34938713

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	156.23	15.22	52	8982	8499	79726855
Aplastic anaemia	118.86	15.22	52	8982	17853	79717501
Appendicitis	114.51	15.22	53	8981	20741	79714613
Cardiogenic shock	92.06	15.22	58	8976	41856	79693498
Ventricular fibrillation	77.26	15.22	47	8987	31879	79703475
Abdominal distension	72.28	15.22	78	8956	119572	79615782
Sepsis	61.90	15.22	110	8924	269318	79466036
Ascites	59.76	15.22	57	8977	75505	79659849
Blood phosphorus increased	58.91	15.22	27	9007	10320	79725034
Lymphocyte count decreased	58.36	15.22	46	8988	47243	79688111
Cytokine release syndrome	57.78	15.22	41	8993	35957	79699397
Intestinal pseudo-obstruction	56.28	15.22	18	9016	2591	79732763
Stress	55.40	15.22	56	8978	79556	79655798
Hypogonadism	54.38	15.22	16	9018	1744	79733610
Incision site pain	46.90	15.22	16	9018	2814	79732540
Multiple organ dysfunction syndrome	45.71	15.22	62	8972	120184	79615170
Vomiting	42.44	15.22	168	8866	665660	79069694
Abdominal pain	40.52	15.22	116	8918	389453	79345901
Acute phosphate nephropathy	36.43	15.22	6	9028	39	79735315
Myasthenia gravis	35.03	15.22	19	9015	10380	79724974
Red blood cells urine positive	34.83	15.22	15	9019	4948	79730406
Hypophosphataemia	32.69	15.22	23	9011	19890	79715464
Blood uric acid increased	30.60	15.22	19	9015	13341	79722013
Mucosal inflammation	30.28	15.22	40	8994	75540	79659814
Hyponatraemia	30.23	15.22	64	8970	177784	79557570
Blood urea increased	29.76	15.22	32	9002	48758	79686596
Blood albumin decreased	28.65	15.22	23	9011	24220	79711134
Loss of bladder sensation	25.41	15.22	5	9029	96	79735258
Protein urine present	24.74	15.22	15	9019	10097	79725257
Drug ineffective	22.89	15.22	56	8978	1080857	78654497
Mutism	22.88	15.22	9	9025	2363	79732991
Nausea	21.52	15.22	183	8851	957013	78778341
Food refusal	21.36	15.22	6	9028	554	79734800
Neutrophil count increased	21.02	15.22	21	9013	29375	79705979
Blood phosphorus decreased	19.22	15.22	11	9023	6657	79728697
Neutropenic sepsis	18.74	15.22	19	9015	27045	79708309
General physical health deterioration	18.69	15.22	71	8963	275167	79460187
Intestinal obstruction	17.58	15.22	23	9011	42997	79692357
Drug interaction	17.38	15.22	13	9021	415170	79320184
Hyperphosphataemia	17.01	15.22	10	9024	6366	79728988
Procedural pain	15.61	15.22	16	9018	23068	79712286
Bilirubin conjugated increased	15.60	15.22	9	9025	5530	79729824

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A06AD17	ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Osmotically acting laxatives
ATC	A06AG01	ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Enemas
ATC	B05XA09	BLOOD AND BLOOD FORMING ORGANS BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS I.V. SOLUTION ADDITIVES Electrolyte solutions
ATC	V03AG05	VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Drugs for treatment of hypercalcemia

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Constipation	indication	14760008	DOID:2089

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Carbonic anhydrase 4	Enzyme	P22748	CAH4_HUMAN		Ki	5.01		CHEMBL

External reference:

ID	Source
4018050	VUID
N0000146391	NUI
D05869	KEGG_DRUG
7782-85-6	SECONDARY_CAS_RN
4017620	VANDF
4018050	VANDF
4018740	VANDF
4018741	VANDF
C0074757	UMLSCUI
CHEBI:37586	CHEBI
CHEMBL1060	ChEMBL_ID
CHEMBL1368	ChEMBL_ID
CHEMBL2107560	ChEMBL_ID
C018279	MESH_SUPPLEMENTAL_RECORD_UI
SE337SVY37	UNII
24243	PUBCHEM_CID
DB09449	DRUGBANK_ID
DB14502	DRUGBANK_ID
221090	RXNORM
1109	MMSL
12492	MMSL
4575	MMSL
4576	MMSL
4621	MMSL
5491	MMSL
60065	MMSL
NOCODE	MMSL
d00475	MMSL
001188	NDDF
006672	NDDF
006674	NDDF
007397	NDDF
71584004	SNOMEDCT_US
768971002	SNOMEDCT_US
7632-05-5	SECONDARY_CAS_RN

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Fleet for Children	HUMAN OTC DRUG LABEL	2	0132-0058	ENEMA	3.50 g	RECTAL	EXPORT ONLY	12 sections
Fleet for Children	HUMAN OTC DRUG LABEL	2	0132-0058	ENEMA	3.50 g	RECTAL	EXPORT ONLY	12 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0201	ENEMA	7 g	RECTAL	OTC monograph not final	12 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0201	ENEMA	7 g	RECTAL	OTC monograph not final	12 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0201	ENEMA	7 g	RECTAL	OTC monograph not final	12 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0201	ENEMA	7 g	RECTAL	OTC monograph not final	12 sections
Pedia-Lax	HUMAN OTC DRUG LABEL	2	0132-0202	ENEMA	3.50 g	RECTAL	OTC monograph not final	13 sections
Pedia-Lax	HUMAN OTC DRUG LABEL	2	0132-0202	ENEMA	3.50 g	RECTAL	OTC monograph not final	13 sections
Pedia-Lax	HUMAN OTC DRUG LABEL	2	0132-0202	ENEMA	3.50 g	RECTAL	OTC monograph not final	13 sections
Pedia-Lax	HUMAN OTC DRUG LABEL	2	0132-0202	ENEMA	3.50 g	RECTAL	OTC monograph not final	13 sections
Fleet for Children	HUMAN OTC DRUG LABEL	2	0132-0207	ENEMA	3.50 g	RECTAL	Export only	12 sections
Fleet for Children	HUMAN OTC DRUG LABEL	2	0132-0207	ENEMA	3.50 g	RECTAL	Export only	12 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0525	ENEMA	7 g	RECTAL	Export only	12 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0525	ENEMA	7 g	RECTAL	Export only	12 sections
Fleet for Children	HUMAN OTC DRUG LABEL	2	0132-0526	ENEMA	3.50 g	RECTAL	Export only	12 sections
Fleet for Children	HUMAN OTC DRUG LABEL	2	0132-0526	ENEMA	3.50 g	RECTAL	Export only	12 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0527	ENEMA	7 g	RECTAL	Export only	12 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0527	ENEMA	7 g	RECTAL	Export only	12 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0528	ENEMA	7 g	RECTAL	Export only	11 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0528	ENEMA	7 g	RECTAL	Export only	11 sections
Fleet for Children	HUMAN OTC DRUG LABEL	2	0132-0529	ENEMA	3.50 g	RECTAL	Export only	12 sections
Fleet for Children	HUMAN OTC DRUG LABEL	2	0132-0529	ENEMA	3.50 g	RECTAL	Export only	12 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0530	LIQUID	2.70 g	ORAL	export only	11 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0530	LIQUID	2.70 g	ORAL	export only	11 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0531	LIQUID	2.70 g	ORAL	export only	11 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0531	LIQUID	2.70 g	ORAL	export only	11 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0532	ENEMA	7 g	RECTAL	Export only	12 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0532	ENEMA	7 g	RECTAL	Export only	12 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0534	ENEMA	7 g	RECTAL	export only	11 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0534	ENEMA	7 g	RECTAL	export only	11 sections