isopropanol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4215 67-63-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • isopropyl alcohol
  • 2-Propanol
  • iso-Propanol
  • isopropanol
An isomer of 1-PROPANOL. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.
  • Molecular weight: 60.10
  • Formula: C3H8O
  • CLOGP: 0.07
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: 0.80
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 5052.08 17.01 1978 21349 129911 50451886
Toxicity to various agents 2919.97 17.01 1566 21761 210933 50370864
Drug abuse 1458.89 17.01 656 22671 59190 50522607
Cardio-respiratory arrest 1012.66 17.01 494 22833 53398 50528399
Intentional overdose 1006.77 17.01 516 22811 61988 50519809
Overdose 719.77 17.01 490 22837 99237 50482560
Suicide attempt 594.83 17.01 342 22985 51390 50530407
Alcohol interaction 447.61 17.01 118 23209 2026 50579771
Suspected suicide 376.21 17.01 127 23200 5230 50576567
Respiratory arrest 283.49 17.01 175 23152 29834 50551963
Intentional product misuse 265.65 17.01 199 23128 46535 50535262
Alcohol poisoning 241.39 17.01 70 23257 1730 50580067
Cardiac arrest 232.76 17.01 237 23090 83414 50498383
Alcohol use 208.54 17.01 64 23263 1931 50579866
Coma 168.85 17.01 167 23160 56712 50525085
Alcohol abuse 165.36 17.01 53 23274 1848 50579949
Death 149.70 17.01 406 22921 324973 50256824
Somnolence 141.62 17.01 255 23072 154730 50427067
Methaemoglobinaemia 130.01 17.01 45 23282 1997 50579800
Exposure to toxic agent 124.62 17.01 51 23276 3607 50578190
Diarrhoea 117.23 17.01 63 23264 588413 49993384
Loss of consciousness 88.02 17.01 166 23161 104187 50477610
Poisoning deliberate 87.23 17.01 51 23276 7861 50573936
Blood alcohol increased 83.73 17.01 24 23303 568 50581229
Mydriasis 80.55 17.01 54 23273 10573 50571224
Agitation 77.98 17.01 109 23218 53275 50528522
Alcoholism 77.88 17.01 29 23298 1591 50580206
Postmortem blood drug level abnormal 76.12 17.01 20 23307 338 50581459
Irritable bowel syndrome 75.09 17.01 105 23222 51336 50530461
Intentional self-injury 72.51 17.01 70 23257 23042 50558755
Substance abuse 71.81 17.01 36 23291 4088 50577709
Drug ineffective 67.41 17.01 177 23150 819156 49762641
Pneumonia 66.14 17.01 47 23280 378354 50203443
Headache 62.07 17.01 86 23241 506449 50075348
Poisoning 59.80 17.01 48 23279 12381 50569416
Off label use 59.67 17.01 79 23248 474347 50107450
Pain in extremity 59.01 17.01 26 23301 272839 50308958
Seizure 57.87 17.01 151 23176 117723 50464074
Liver injury 57.72 17.01 64 23263 24742 50557055
Drug use disorder 56.99 17.01 28 23299 3044 50578753
Aggression 55.31 17.01 58 23269 21058 50560739
Drug dependence 54.86 17.01 56 23271 19703 50562094
Cough 53.74 17.01 22 23305 241242 50340555
Product dose omission issue 53.49 17.01 10 23317 183828 50397969
Myocarditis 52.25 17.01 37 23290 7910 50573887
Fatigue 52.10 17.01 161 23166 707440 49874357
Victim of sexual abuse 51.43 17.01 16 23311 505 50581292
Helicobacter infection 50.75 17.01 86 23241 49616 50532181
Drug withdrawal syndrome 50.41 17.01 60 23267 25021 50556776
Nausea 50.17 17.01 163 23164 705235 49876562
Back pain 49.10 17.01 20 23307 220010 50361787
Muscle injury 48.65 17.01 72 23255 37039 50544758
Ill-defined disorder 47.35 17.01 88 23239 54566 50527231
Depressed level of consciousness 44.19 17.01 83 23244 51870 50529927
Folliculitis 42.89 17.01 70 23257 39155 50542642
Suicidal ideation 41.64 17.01 84 23243 55301 50526496
Malaise 38.04 17.01 60 23267 335472 50246325
Chemical submission 37.47 17.01 10 23317 180 50581617
Dyspnoea 37.16 17.01 129 23198 547479 50034318
Pericarditis 35.76 17.01 98 23229 78591 50503206
Urinary tract infection 35.07 17.01 31 23296 223989 50357808
Somnambulism 34.88 17.01 24 23303 4900 50576897
Anaemia 34.87 17.01 39 23288 252417 50329380
Asthenia 34.35 17.01 59 23268 318983 50262814
Tachycardia 33.78 17.01 112 23215 99651 50482146
Asphyxia 32.78 17.01 24 23303 5403 50576394
Contusion 31.99 17.01 119 23208 112064 50469733
Protein C increased 31.92 17.01 8 23319 111 50581686
Abnormal behaviour 31.50 17.01 42 23285 19616 50562181
Constipation 31.17 17.01 24 23303 185684 50396113
Sopor 31.13 17.01 42 23285 19837 50561960
Homicide 30.83 17.01 10 23317 362 50581435
Duodenal ulcer perforation 30.57 17.01 66 23261 45545 50536252
Ventricular tachycardia 30.40 17.01 37 23290 15784 50566013
Cyanosis 29.98 17.01 36 23291 15148 50566649
Accidental death 29.70 17.01 15 23312 1729 50580068
Weight decreased 29.65 17.01 35 23292 221210 50360587
Therapeutic product effect incomplete 28.79 17.01 4 23323 91511 50490286
Electrocardiogram QRS complex prolonged 28.64 17.01 22 23305 5322 50576475
Drug interaction 28.38 17.01 173 23154 199448 50382349
Rash 27.68 17.01 106 23221 437365 50144432
Substance dependence 27.64 17.01 8 23319 196 50581601
Condition aggravated 27.55 17.01 60 23267 296998 50284799
Pain 27.37 17.01 156 23171 578747 50003050
Arthralgia 27.31 17.01 107 23220 438595 50143202
Blister 27.24 17.01 94 23233 85324 50496473
Metabolic acidosis 26.96 17.01 57 23270 38768 50543029
Arthritis 26.80 17.01 4 23323 86717 50495080
Induced abortion failed 26.53 17.01 8 23319 227 50581570
Mobility decreased 26.35 17.01 3 23324 79945 50501852
Medication error 26.23 17.01 54 23273 36050 50545747
Electrocardiogram ST segment elevation 24.77 17.01 17 23310 3456 50578341
Neuropathy peripheral 24.67 17.01 7 23320 96750 50485047
Decreased appetite 24.62 17.01 34 23293 200889 50380908
Confusional state 24.46 17.01 158 23169 185770 50396027
Congenital umbilical hernia 24.27 17.01 8 23319 305 50581492
Electrocardiogram QT prolonged 23.94 17.01 65 23262 51821 50529976
White blood cell count decreased 23.84 17.01 12 23315 116710 50465087
Disinhibition 23.25 17.01 10 23317 800 50580997
Erythema 23.21 17.01 20 23307 146394 50435403
Sinus tachycardia 23.19 17.01 38 23289 21316 50560481
Areflexia 23.19 17.01 15 23312 2765 50579032
Drug abuser 22.95 17.01 15 23312 2813 50578984
Amnesia 22.64 17.01 56 23271 42204 50539593
Neutropenia 22.52 17.01 21 23306 147944 50433853
Unresponsive to stimuli 22.49 17.01 46 23281 30563 50551234
Herpes zoster 22.49 17.01 3 23324 70783 50511014
Alcoholic 22.45 17.01 5 23322 40 50581757
Postmortem blood drug level 22.43 17.01 6 23321 109 50581688
Toxicologic test abnormal 22.29 17.01 9 23318 614 50581183
Blood ethanol increased 22.23 17.01 6 23321 113 50581684
Pyrexia 22.22 17.01 95 23232 380108 50201689
Loss of personal independence in daily activities 22.18 17.01 3 23324 70047 50511750
Fall 21.91 17.01 80 23247 334852 50246945
Shock 21.42 17.01 36 23291 20614 50561183
Birth mark 21.35 17.01 6 23321 132 50581665
Bronchitis 20.83 17.01 11 23316 104148 50477649
Drug hypersensitivity 20.64 17.01 54 23273 250956 50330841
Sleep disorder due to general medical condition, insomnia type 20.49 17.01 45 23282 31402 50550395
Cerebrovascular accident 20.46 17.01 9 23318 94671 50487126
Drug screen positive 20.44 17.01 15 23312 3387 50578410
Amphetamines positive 20.39 17.01 6 23321 156 50581641
Euphoric mood 20.23 17.01 16 23311 4039 50577758
Respiratory depression 19.76 17.01 26 23301 11984 50569813
Opiates positive 19.69 17.01 7 23320 336 50581461
Blood lactic acid increased 19.59 17.01 18 23309 5567 50576230
Road traffic accident 19.58 17.01 38 23289 24314 50557483
Psoriasis 19.53 17.01 4 23323 68996 50512801
Abdominal pain upper 19.47 17.01 27 23300 159282 50422515
Haemoglobin decreased 19.42 17.01 18 23309 127198 50454599
Oropharyngeal pain 19.16 17.01 6 23321 77795 50504002
Impaired healing 19.03 17.01 73 23254 69713 50512084
Sepsis 18.92 17.01 20 23307 132905 50448892
Hepatic failure 18.60 17.01 44 23283 32239 50549558
Influenza 18.59 17.01 9 23318 89529 50492268
Brain death 18.39 17.01 13 23314 2770 50579027
Aspiration 18.34 17.01 22 23305 9242 50572555
Migraine 18.19 17.01 6 23321 75274 50506523
Dizziness 17.60 17.01 91 23236 346278 50235519
Accidental overdose 17.59 17.01 32 23295 19501 50562296
Alcohol withdrawal syndrome 17.55 17.01 8 23319 735 50581062
Musculoskeletal stiffness 17.55 17.01 20 23307 128461 50453336
Restlessness 17.52 17.01 37 23290 25136 50556661
Incorrect route of product administration 17.35 17.01 31 23296 18635 50563162
Congestive hepatopathy 17.30 17.01 12 23315 2482 50579315
Tearfulness 17.22 17.01 14 23313 3673 50578124
Febrile neutropenia 17.18 17.01 12 23315 97655 50484142
Treatment failure 17.14 17.01 23 23304 137614 50444183
Asthma 17.05 17.01 10 23317 89327 50492470

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 4054.77 18.24 1704 21384 78179 29473260
Completed suicide 3490.25 18.24 1591 21497 88655 29462784
Toxicity to various agents 3073.61 18.24 1808 21280 171853 29379586
Intentional overdose 758.10 18.24 434 22654 38094 29513345
Cardio-respiratory arrest 717.55 18.24 462 22626 50139 29501300
Overdose 580.58 18.24 487 22601 79332 29472107
Alcohol abuse 519.59 18.24 175 22913 4158 29547281
Alcohol interaction 487.90 18.24 149 22939 2554 29548885
Intentional product misuse 455.25 18.24 302 22786 34359 29517080
Suicide attempt 452.36 18.24 299 22789 33811 29517628
Suspected suicide 350.15 18.24 128 22960 3892 29547547
Alcohol poisoning 271.39 18.24 99 22989 2990 29548449
Substance abuse 269.41 18.24 123 22965 6664 29544775
Drug dependence 254.09 18.24 174 22914 20807 29530632
Respiratory arrest 175.56 18.24 152 22936 25681 29525758
Aggression 173.67 18.24 174 22914 35367 29516072
Alcohol use 167.35 18.24 70 23018 3062 29548377
Coma 167.31 18.24 179 22909 39271 29512168
Respiratory depression 146.95 18.24 105 22983 13418 29538021
Poisoning deliberate 138.21 18.24 74 23014 5657 29545782
Exposure to toxic agent 129.07 18.24 55 23033 2520 29548919
Asphyxia 120.84 18.24 66 23022 5249 29546190
Cardiac arrest 104.74 18.24 216 22872 85375 29466064
Diarrhoea 104.13 18.24 66 23022 332632 29218807
Incorrect route of product administration 101.84 18.24 77 23011 10724 29540715
Blood alcohol increased 101.53 18.24 33 23055 697 29550742
Intentional product use issue 100.83 18.24 144 22944 42354 29509085
Drug ineffective 94.58 18.24 87 23001 363083 29188356
Pneumonia 91.56 18.24 70 23018 320102 29231337
Suicidal ideation 88.84 18.24 122 22966 34594 29516845
Poisoning 84.96 18.24 67 23021 9926 29541513
Off label use 78.29 18.24 72 23016 300728 29250711
Fatigue 77.65 18.24 80 23008 316741 29234698
Drug withdrawal syndrome 76.86 18.24 82 23006 17902 29533537
Alcohol withdrawal syndrome 71.04 18.24 30 23058 1343 29550096
Intentional self-injury 70.16 18.24 66 23022 12395 29539044
Anaemia 68.21 18.24 36 23052 200915 29350524
Pyrexia 67.78 18.24 75 23013 287547 29263892
Sopor 65.60 18.24 60 23028 10874 29540565
Cough 57.71 18.24 14 23074 126713 29424726
Agitation 57.48 18.24 125 22963 51179 29500260
Neutropenia 55.39 18.24 17 23071 131694 29419745
Drug use disorder 55.18 18.24 34 23054 3388 29548051
Dyspnoea 53.87 18.24 109 22979 326623 29224816
Miosis 52.09 18.24 46 23042 7963 29543476
Medication error 51.93 18.24 73 23015 21138 29530301
Mydriasis 50.00 18.24 40 23048 6045 29545394
Drug interaction 49.80 18.24 293 22795 197092 29354347
Methaemoglobinaemia 49.44 18.24 29 23059 2642 29548797
Road traffic accident 48.03 18.24 60 23028 15501 29535938
Alcohol intolerance 47.50 18.24 16 23072 379 29551060
Accidental death 47.30 18.24 26 23062 2092 29549347
Product dose omission issue 47.23 18.24 9 23079 96374 29455065
Drug screen positive 47.08 18.24 32 23056 3769 29547670
Alcoholism 46.92 18.24 28 23060 2633 29548806
Hepatic fibrosis 46.64 18.24 30 23058 3222 29548217
Tachycardia 46.41 18.24 143 22945 72267 29479172
Rash 46.30 18.24 48 23040 189771 29361668
Arthralgia 45.88 18.24 26 23062 139591 29411848
Death 44.41 18.24 434 22654 341650 29209789
Depressed level of consciousness 43.65 18.24 92 22996 36850 29514589
Ex-drug abuser 43.36 18.24 12 23076 142 29551297
Sepsis 40.88 18.24 31 23057 142651 29408788
Loss of consciousness 40.02 18.24 138 22950 73918 29477521
Amnesia 40.00 18.24 67 23021 22576 29528863
Pain 39.96 18.24 45 23043 171387 29380052
Febrile neutropenia 38.18 18.24 20 23068 112220 29439219
Drug abuser 37.66 18.24 28 23060 3799 29547640
Back pain 36.64 18.24 17 23071 102267 29449172
Constipation 36.44 18.24 22 23066 114138 29437301
Cerebrovascular accident 35.98 18.24 8 23080 76903 29474536
Impaired driving ability 34.66 18.24 22 23066 2309 29549130
Somnolence 34.47 18.24 155 22933 93800 29457639
Withdrawal syndrome 33.31 18.24 42 23046 10950 29540489
Decreased appetite 32.94 18.24 39 23049 145303 29406136
Pulmonary oedema 32.75 18.24 90 22998 42645 29508794
Pruritus 32.68 18.24 26 23062 116823 29434616
Dysarthria 31.99 18.24 73 23015 30838 29520601
Asthenia 31.92 18.24 76 23012 215174 29336265
General physical health deterioration 31.21 18.24 21 23067 102836 29448603
Homicide 31.18 18.24 15 23073 913 29550526
Metabolic acidosis 30.55 18.24 81 23007 37581 29513858
Foetal alcohol syndrome 30.50 18.24 9 23079 136 29551303
Pain in extremity 30.35 18.24 25 23063 110408 29441031
Condition aggravated 30.31 18.24 42 23046 146253 29405186
Malignant neoplasm progression 30.19 18.24 10 23078 73849 29477590
Pancytopenia 29.50 18.24 14 23074 83154 29468285
Nausea 28.32 18.24 123 22965 289132 29262307
Shock 27.27 18.24 55 23033 21349 29530090
Abnormal behaviour 26.62 18.24 57 23031 23070 29528369
Nasopharyngitis 26.35 18.24 7 23081 59658 29491781
Myocardial fibrosis 26.33 18.24 14 23074 1054 29550385
Physical assault 26.13 18.24 14 23074 1070 29550369
Platelet count decreased 26.01 18.24 26 23062 104646 29446793
Urinary tract infection 25.94 18.24 12 23076 72342 29479097
Disease progression 25.83 18.24 16 23072 81900 29469539
Opiates positive 25.66 18.24 11 23077 511 29550928
Cardiac failure congestive 25.51 18.24 14 23074 76567 29474872
Peripheral swelling 25.41 18.24 9 23079 63730 29487709
Neuropathy peripheral 25.12 18.24 12 23076 71015 29480424
Rhabdomyolysis 25.11 18.24 104 22984 60704 29490735
Drug intolerance 24.81 18.24 4 23084 48375 29503064
Sensorimotor disorder 24.76 18.24 10 23078 399 29551040
Haemoglobin decreased 24.62 18.24 29 23059 108346 29443093
Cardiac failure 24.30 18.24 16 23072 79271 29472168
Somnambulism 24.29 18.24 19 23069 2779 29548660
Infection 24.19 18.24 15 23073 76736 29474703
White blood cell count decreased 23.99 18.24 18 23070 83344 29468095
Joint swelling 23.53 18.24 5 23083 49625 29501814
Product use in unapproved indication 23.45 18.24 20 23068 86855 29464584
Accidental overdose 23.36 18.24 46 23042 17547 29533892
Gun shot wound 23.35 18.24 13 23075 1072 29550367
Interstitial lung disease 23.26 18.24 8 23080 57710 29493729
Dextrocardia 23.23 18.24 7 23081 114 29551325
Thrombocytopenia 22.96 18.24 44 23044 134779 29416660
Brain oedema 22.71 18.24 37 23051 12183 29539256
Muscular weakness 22.70 18.24 10 23078 62042 29489397
Disorientation 22.44 18.24 62 23026 29453 29521986
Unresponsive to stimuli 22.39 18.24 56 23032 25070 29526369
Malaise 22.34 18.24 58 23030 159544 29391895
Weight decreased 21.77 18.24 54 23034 150851 29400588
Renal impairment 21.61 18.24 19 23069 81314 29470125
Pleural effusion 21.38 18.24 15 23073 71893 29479546
Urticaria 21.31 18.24 8 23080 54652 29496787
Dehydration 20.83 18.24 36 23052 114712 29436727
Substance-induced mood disorder 20.63 18.24 6 23082 86 29551353
Suicidal behaviour 20.59 18.24 13 23075 1352 29550087
Pupil fixed 20.35 18.24 14 23074 1682 29549757
Oedema peripheral 20.18 18.24 31 23057 103526 29447913
Chemical poisoning 20.13 18.24 6 23082 94 29551345
Myocardial infarction 19.65 18.24 35 23053 110261 29441178
Atrial fibrillation 19.30 18.24 33 23055 105613 29445826
Weight increased 19.09 18.24 19 23069 76648 29474791
Accidental poisoning 18.69 18.24 9 23079 549 29550890
Alcoholic liver disease 18.66 18.24 9 23079 551 29550888
Septic shock 18.66 18.24 13 23075 62547 29488892
COVID-19 18.42 18.24 3 23085 36011 29515428
Deep vein thrombosis 18.39 18.24 11 23077 57388 29494051

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 8140.72 15.76 3527 36706 220887 64237612
Toxicity to various agents 5818.66 15.76 3276 36957 360237 64098262
Drug abuse 5341.88 15.76 2254 37979 130120 64328379
Cardio-respiratory arrest 1718.23 15.76 948 39285 97445 64361054
Intentional overdose 1429.23 15.76 815 39418 89129 64369370
Overdose 1075.30 15.76 848 39385 158718 64299781
Alcohol interaction 778.59 15.76 227 40006 4174 64454325
Intentional product misuse 695.54 15.76 477 39756 71818 64386681
Suspected suicide 661.61 15.76 236 39997 8418 64450081
Suicide attempt 658.34 15.76 458 39775 70549 64387950
Alcohol abuse 514.17 15.76 169 40064 4683 64453816
Respiratory arrest 440.56 15.76 320 39913 52665 64405834
Alcohol poisoning 414.09 15.76 139 40094 4116 64454383
Cardiac arrest 319.36 15.76 435 39798 153629 64304870
Alcohol use 316.12 15.76 116 40117 4486 64454013
Coma 297.53 15.76 318 39915 87297 64371202
Substance abuse 283.45 15.76 131 40102 9161 64449338
Drug dependence 269.52 15.76 198 40035 33114 64425385
Death 260.67 15.76 774 39459 481931 63976568
Exposure to toxic agent 246.31 15.76 105 40128 6054 64452445
Poisoning deliberate 210.40 15.76 121 40112 13337 64445162
Diarrhoea 195.78 15.76 104 40129 722600 63735899
Aggression 175.09 15.76 178 40055 46054 64412445
Drug ineffective 170.04 15.76 165 40068 840082 63618417
Methaemoglobinaemia 163.58 15.76 71 40162 4277 64454222
Blood alcohol increased 161.61 15.76 50 40183 1132 64457367
Off label use 159.90 15.76 99 40134 632707 63825792
Fatigue 129.42 15.76 167 40066 748563 63709936
Poisoning 125.04 15.76 106 40127 21773 64436726
Pneumonia 123.57 15.76 101 40132 559475 63899024
Respiratory depression 118.70 15.76 106 40127 23337 64435162
Asphyxia 118.34 15.76 74 40159 9492 64449007
Intentional self-injury 117.62 15.76 116 40117 28928 64429571
Agitation 115.73 15.76 202 40031 88165 64370334
Incorrect route of product administration 115.30 15.76 104 40129 23194 64435305
Somnolence 110.67 15.76 328 39905 203317 64255182
Dyspnoea 108.67 15.76 176 40057 718498 63740001
Mydriasis 101.77 15.76 81 40152 15231 64443268
Drug use disorder 101.53 15.76 57 40176 5997 64452502
Cough 98.27 15.76 33 40200 302115 64156384
Intentional product use issue 96.23 15.76 195 40038 95169 64363330
Arthralgia 91.26 15.76 85 40148 442175 64016324
Headache 90.36 15.76 119 40114 529348 63929151
Nausea 90.07 15.76 226 40007 785574 63672925
Loss of consciousness 89.31 15.76 248 39985 148117 64310382
Pain in extremity 88.78 15.76 39 40194 303046 64155453
Anaemia 87.71 15.76 65 40168 378615 64079884
Postmortem blood drug level abnormal 82.71 15.76 26 40207 621 64457878
Suicidal ideation 80.54 15.76 147 40086 66395 64392104
Medication error 79.89 15.76 125 40108 49841 64408658
Pain 79.42 15.76 140 40093 553371 63905128
Back pain 78.45 15.76 29 40204 250142 64208357
Alcoholism 76.51 15.76 39 40194 3378 64455121
Accidental death 76.17 15.76 40 40193 3685 64454814
Depressed level of consciousness 75.67 15.76 161 40072 81275 64377224
Pyrexia 75.10 15.76 147 40086 558497 63900002
Product dose omission issue 71.18 15.76 17 40216 194730 64263769
Alcohol withdrawal syndrome 69.65 15.76 30 40203 1773 64456726
Sopor 67.80 15.76 88 40145 29573 64428926
Miosis 67.17 15.76 60 40173 13206 64445293
Urinary tract infection 65.92 15.76 31 40202 231565 64226934
Joint swelling 65.80 15.76 26 40207 215356 64243143
Tachycardia 65.69 15.76 224 40009 149355 64309144
Neutropenia 65.29 15.76 34 40199 239590 64218909
Condition aggravated 65.20 15.76 82 40151 372344 64086155
Malaise 62.59 15.76 94 40139 396153 64062346
Rash 60.42 15.76 122 40111 458427 64000072
Drug abuser 59.70 15.76 40 40193 5768 64452731
Drug withdrawal syndrome 59.63 15.76 85 40148 31206 64427293
Metabolic acidosis 57.69 15.76 133 40100 70825 64387674
Constipation 57.53 15.76 36 40197 229301 64229198
Asthenia 56.28 15.76 114 40119 427930 64030569
Pulmonary oedema 55.94 15.76 140 40093 78534 64379965
Peripheral swelling 55.04 15.76 31 40202 209122 64249377
Drug interaction 52.01 15.76 395 39838 361688 64096811
Decreased appetite 51.24 15.76 60 40173 281229 64177270
Drug screen positive 50.74 15.76 36 40197 5693 64452806
Homicide 50.62 15.76 21 40212 1130 64457369
Febrile neutropenia 50.55 15.76 27 40206 187630 64270869
Shock 49.48 15.76 87 40146 38153 64420346
Therapeutic product effect incomplete 49.47 15.76 4 40229 103478 64355021
Opiates positive 45.02 15.76 18 40215 880 64457619
Weight decreased 44.86 15.76 68 40165 285671 64172828
Cerebrovascular accident 44.72 15.76 15 40218 137568 64320931
Sepsis 44.28 15.76 47 40186 230294 64228205
General physical health deterioration 43.61 15.76 38 40195 204387 64254112
Hepatic fibrosis 40.42 15.76 31 40202 5521 64452978
Liver injury 39.90 15.76 69 40164 29863 64428636
Treatment failure 39.27 15.76 12 40221 116804 64341695
Abnormal behaviour 39.06 15.76 73 40160 33549 64424950
Road traffic accident 38.55 15.76 69 40164 30676 64427823
Pancytopenia 38.03 15.76 21 40212 143288 64315211
Herpes zoster 38.02 15.76 3 40230 79184 64379315
Electrocardiogram QRS complex prolonged 37.56 15.76 37 40196 9207 64449292
Musculoskeletal stiffness 37.39 15.76 15 40218 123191 64335308
Drug hypersensitivity 36.93 15.76 57 40176 237758 64220741
White blood cell count decreased 36.59 15.76 27 40206 157810 64300689
Haemoglobin decreased 36.16 15.76 41 40192 195022 64263477
Unresponsive to stimuli 36.15 15.76 90 40143 50303 64408196
Oropharyngeal pain 36.12 15.76 6 40227 88861 64369638
Blood ethanol increased 35.83 15.76 14 40219 644 64457855
Pruritus 35.48 15.76 90 40143 312310 64146189
Drug intolerance 35.41 15.76 39 40194 187953 64270546
Asthma 35.39 15.76 8 40225 95217 64363282
Sinus tachycardia 35.06 15.76 68 40165 32120 64426379
Upper respiratory tract infection 34.27 15.76 3 40230 72782 64385717
Accidental overdose 34.27 15.76 69 40164 33488 64425011
Rhabdomyolysis 33.97 15.76 130 40103 91596 64366903
Somnambulism 33.74 15.76 27 40206 5114 64453385
Toxicologic test abnormal 33.43 15.76 16 40217 1209 64457290
Cardiac failure congestive 33.41 15.76 20 40213 130560 64327939
Product administration error 33.34 15.76 61 40172 27582 64430917
Muscular weakness 33.30 15.76 19 40214 127319 64331180
Blood ethanol 33.13 15.76 9 40224 126 64458373
Chemical submission 32.67 15.76 10 40223 218 64458281
Abdominal pain 32.46 15.76 94 40139 312281 64146218
Fall 32.29 15.76 142 40091 416684 64041815
Amphetamines positive 32.13 15.76 10 40223 231 64458268
Euphoric mood 31.77 15.76 29 40204 6562 64451937
Postmortem blood drug level 31.16 15.76 10 40223 256 64458243
Alcohol intolerance 30.95 15.76 11 40222 387 64458112
Erythema 30.83 15.76 43 40190 187027 64271472
Malignant neoplasm progression 30.74 15.76 16 40217 112855 64345644
Product use in unapproved indication 30.73 15.76 39 40194 176579 64281920
Victim of sexual abuse 30.71 15.76 11 40222 396 64458103
Influenza 30.68 15.76 14 40219 106517 64351982
Exposure via ingestion 30.59 15.76 25 40208 4877 64453622
Amnesia 30.30 15.76 82 40151 48187 64410312
Neuropathy peripheral 30.07 15.76 18 40215 117507 64340992
Dehydration 29.93 15.76 56 40177 216707 64241792
Myocardial fibrosis 29.58 15.76 16 40217 1564 64456935
Loss of personal independence in daily activities 29.21 15.76 5 40228 72449 64386050
Cellulitis 29.08 15.76 11 40222 93646 64364853
Bronchitis 28.75 15.76 16 40217 108727 64349772
Substance dependence 28.72 15.76 11 40222 479 64458020
Septic shock 28.63 15.76 15 40218 105422 64353077
Nasopharyngitis 28.55 15.76 49 40184 196024 64262475
Urticaria 28.36 15.76 30 40203 147287 64311212
Acute kidney injury 28 15.76 165 40068 449075 64009424
Interstitial lung disease 27.90 15.76 13 40220 97719 64360780
Dysarthria 27.85 15.76 91 40142 59315 64399184
Rheumatoid arthritis 27.84 15.76 37 40196 164257 64294242
Renal impairment 27.70 15.76 26 40207 134991 64323508
Irritable bowel syndrome 27.07 15.76 67 40166 37302 64421197
Inappropriate schedule of product administration 26.78 15.76 12 40221 92274 64366225
Seizure 26.72 15.76 187 40046 166705 64291794
Nasal congestion 26.67 15.76 3 40230 59655 64398844
Injection site erythema 26.21 15.76 6 40227 70794 64387705
Withdrawal syndrome 26.04 15.76 50 40183 23442 64435057
Disease progression 26.01 15.76 30 40203 141650 64316849
Pulmonary embolism 25.79 15.76 32 40201 146324 64312175
Thrombocytopenia 25.76 15.76 64 40169 223737 64234762
Brain oedema 25.72 15.76 48 40185 22027 64436472
Abdominal distension 25.56 15.76 14 40219 95980 64362519
Impaired driving ability 25.46 15.76 22 40211 4632 64453867
Restlessness 25.38 15.76 68 40165 39717 64418782
Protein C increased 25.38 15.76 7 40226 104 64458395
Respiratory acidosis 25.31 15.76 31 40202 9824 64448675
COVID-19 25.17 15.76 5 40228 65135 64393364
Physical assault 24.42 15.76 14 40219 1532 64456967
Substance use disorder 24.27 15.76 9 40224 358 64458141
Chest discomfort 24.24 15.76 22 40211 116084 64342415
Electrocardiogram QT prolonged 24.19 15.76 106 40127 79342 64379157
Arthritis 24.16 15.76 11 40222 83803 64374696
Wheezing 24.14 15.76 10 40223 80569 64377930
Dyspnoea exertional 24.02 15.76 8 40225 73722 64384777
Gastrooesophageal reflux disease 23.83 15.76 11 40222 83132 64375367
Weight increased 23.79 15.76 62 40171 213286 64245213
Colitis 23.76 15.76 4 40229 58670 64399829
C-reactive protein increased 23.63 15.76 15 40218 94894 64363605
Abdominal pain upper 23.47 15.76 46 40187 174984 64283515
Pupil fixed 23.43 15.76 18 40215 3214 64455285
Injection site pain 23.39 15.76 21 40212 111387 64347112
Dizziness 23.23 15.76 165 40068 429998 64028501
Psoriasis 22.98 15.76 8 40225 71695 64386804
Stress 22.66 15.76 5 40228 60529 64397970
Platelet count decreased 22.55 15.76 44 40189 167667 64290832
Accidental poisoning 22.53 15.76 13 40220 1440 64457059
Chest pain 22.38 15.76 74 40159 235906 64222593
Cardiac failure 22.23 15.76 30 40203 132343 64326156
Bezoar 22.23 15.76 15 40218 2188 64456311
Productive cough 22.06 15.76 9 40224 73194 64385305
Cataract 21.89 15.76 3 40230 51259 64407240
Deep vein thrombosis 21.88 15.76 20 40213 105162 64353337
Induced abortion failed 21.63 15.76 7 40226 184 64458315
Oedema peripheral 21.31 15.76 64 40169 210253 64248246
Acute hepatic failure 21.27 15.76 49 40184 26063 64432436
Acidosis 21.12 15.76 39 40194 17756 64440743
Rash pruritic 20.98 15.76 5 40228 57399 64401100
Hypertension 20.85 15.76 87 40146 259174 64199325
Thrombosis 20.78 15.76 9 40224 70633 64387866
Sensorimotor disorder 20.56 15.76 10 40223 783 64457716
Electrocardiogram ST segment elevation 20.56 15.76 24 40209 7235 64451264
Substance-induced mood disorder 20.43 15.76 6 40227 113 64458386
Osteoarthritis 20.41 15.76 7 40226 63329 64395170
Migraine 20.07 15.76 7 40226 62670 64395829
Bone marrow failure 20.02 15.76 3 40230 47949 64410550
Hospitalisation 19.97 15.76 11 40222 75196 64383303
Infusion related reaction 19.73 15.76 46 40187 164421 64294078
Pulmonary congestion 19.66 15.76 45 40188 23835 64434664
Coma scale abnormal 19.24 15.76 24 40209 7750 64450749
Leukopenia 19.05 15.76 21 40212 101221 64357278
Pleural effusion 19.00 15.76 31 40202 126528 64331971
Plasma cell myeloma 18.97 15.76 3 40230 46072 64412427
Sudden death 18.96 15.76 40 40193 20056 64438443
Blood pressure systolic increased 18.69 15.76 4 40229 49449 64409050
Haematochezia 18.68 15.76 9 40224 66364 64392135
Myocardial infarction 18.62 15.76 48 40185 165773 64292726
Suicidal behaviour 18.60 15.76 15 40218 2872 64455627
Hepatitis alcoholic 18.58 15.76 8 40225 472 64458027
Cyanosis 18.52 15.76 42 40191 22113 64436386
Fluid retention 18.50 15.76 7 40226 59599 64398900
Chemical poisoning 18.36 15.76 6 40227 163 64458336
Cardiac death 18.28 15.76 11 40222 1317 64457182
Congestive hepatopathy 18.22 15.76 17 40216 3956 64454543
Neck pain 17.85 15.76 8 40225 61525 64396974
Gun shot wound 17.79 15.76 10 40223 1054 64457445
Incoherent 17.65 15.76 22 40211 7096 64451403
Dysgeusia 17.38 15.76 4 40229 47043 64411456
Disorientation 17.38 15.76 75 40158 55753 64402746
Rash maculo-papular 17.37 15.76 4 40229 47022 64411477
Atrial fibrillation 17.37 15.76 52 40181 171037 64287462
Drug diversion 17.18 15.76 10 40223 1126 64457373
Injection site reaction 17.18 15.76 4 40229 46660 64411839
Dysphagia 17.14 15.76 25 40208 106787 64351712
Hypotension 17.10 15.76 333 39900 380641 64077858
Brain death 17.10 15.76 18 40215 4843 64453656
Injection site joint infection 16.98 15.76 4 40229 30 64458469
Neutrophil count decreased 16.87 15.76 14 40219 77182 64381317
Infection 16.82 15.76 59 40174 184821 64273678
Chills 16.78 15.76 38 40195 137226 64321273
Chronic obstructive pulmonary disease 16.65 15.76 12 40221 71036 64387463
Drug level increased 16.58 15.76 53 40180 34143 64424356
Gastritis alcoholic 16.43 15.76 4 40229 35 64458464
Blood pressure increased 16.42 15.76 54 40179 172498 64286001
Musculoskeletal pain 16.27 15.76 16 40217 81278 64377221
Alcoholic 16.24 15.76 4 40229 37 64458462
Slow speech 16.22 15.76 12 40221 2025 64456474
Chronic kidney disease 16.08 15.76 8 40225 57911 64400588
Psychiatric disorder prophylaxis 15.96 15.76 4 40229 40 64458459
Pulmonary haemorrhage 15.90 15.76 29 40204 13080 64445419
Drug reaction with eosinophilia and systemic symptoms 15.80 15.76 7 40226 54210 64404289

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D08AX05 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Other antiseptics and disinfectants
CHEBI has role CHEBI:48356 protogenic solvent
MeSH PA D012997 Solvents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Antiseptic preparation indication 261276004
Nausea and vomiting off-label use 16932000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
2%;70% (10.5ML) CHLORAPREP WITH TINT BECTON DICKINSON CO N020832 April 3, 2006 OTC SPONGE TOPICAL 7422388 April 25, 2027 USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY
2%;70% (26ML) CHLORAPREP WITH TINT BECTON DICKINSON CO N020832 May 3, 2005 OTC SPONGE TOPICAL 7422388 April 25, 2027 USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY
2%;70% (3ML) CHLORAPREP WITH TINT BECTON DICKINSON CO N020832 Oct. 10, 2006 OTC SPONGE TOPICAL 7422388 April 25, 2027 USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY
70% ZURAGARD ZUREX PHARMA N210872 April 26, 2019 DISCN SOLUTION TOPICAL 9629368 May 23, 2028 USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY
2%;70% SOLUPREP 3M HEALTH CARE N208288 Aug. 8, 2018 OTC SOLUTION TOPICAL 8623935 July 26, 2029 FOR THE PREPARATION OF SKIN PRIOR TO SURGERY; HELPS REDUCE BACTERIA THAT CAN POTENTIALLY CAUSE SKIN INFECTION
70% ZURAGARD ZUREX PHARMA N210872 April 26, 2019 DISCN SOLUTION TOPICAL 8389583 Aug. 9, 2029 USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY
70% ZURAGARD ZUREX PHARMA N210872 April 26, 2019 DISCN SOLUTION TOPICAL 10688291 Dec. 20, 2034 USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY
70% ZURAGARD ZUREX PHARMA N210872 April 26, 2019 DISCN SOLUTION TOPICAL 9844654 April 24, 2036 USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
70% ZURAGARD ZUREX PHARMA N210872 April 26, 2019 DISCN SOLUTION TOPICAL April 26, 2022 NEW PRODUCT
70% ZURAGARD ZUREX PHARMA N210872 April 26, 2019 DISCN SOLUTION TOPICAL June 24, 2024 ADDITION OF INFORMATION TO THE LABEL REGARDING A CLEAR PRODUCT PRESENTATION AND 26 ML VOLUME PRODUCTS

Bioactivity Summary:

None

External reference:

IDSource
4018437 VUID
N0000146763 NUI
D00137 KEGG_DRUG
4017589 VANDF
4018437 VANDF
CHEBI:17824 CHEBI
IPA PDB_CHEM_ID
CHEMBL582 ChEMBL_ID
DB02325 DRUGBANK_ID
3776 PUBCHEM_CID
797541 RXNORM
11314 MMSL
4930 MMSL
002465 NDDF
259268001 SNOMEDCT_US
414547000 SNOMEDCT_US
D019840 MESH_DESCRIPTOR_UI
C0022237 UMLSCUI
ND2M416302 UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Swim-EAR HUMAN OTC DRUG LABEL 1 0168-0126 SOLUTION 950 mg AURICULAR (OTIC) OTC monograph final 12 sections
Isopropyl Alcohol HUMAN OTC DRUG LABEL 1 0168-0907 SOLUTION 75 mL TOPICAL OTC monograph not final 10 sections
Hibistat HUMAN OTC DRUG LABEL 2 0234-0587 SOLUTION 70 g TOPICAL NDA 13 sections
Isopropyl alcohol70 percent HUMAN OTC DRUG LABEL 1 0363-0275 LIQUID 70 mL TOPICAL OTC monograph not final 13 sections
Isopropyl alcohol91 percent HUMAN OTC DRUG LABEL 1 0363-0277 LIQUID 91 mL TOPICAL OTC monograph not final 12 sections
Isopropyl alcohol70 percent HUMAN OTC DRUG LABEL 1 0363-0472 LIQUID 70 mL TOPICAL OTC MONOGRAPH NOT FINAL 12 sections
Isopropyl Alcohol HUMAN OTC DRUG LABEL 1 0363-0804 LIQUID 0.91 mg TOPICAL OTC monograph not final 13 sections
Walgreen Alcohol HUMAN OTC DRUG LABEL 1 0363-0809 SWAB 70 mL TOPICAL OTC monograph not final 13 sections
70% HUMAN OTC DRUG LABEL 1 0363-0810 LIQUID 500 mg TOPICAL OTC monograph not final 13 sections
70% Rubbing HUMAN OTC DRUG LABEL 1 0363-0845 LIQUID 500 mg TOPICAL OTC monograph not final 12 sections
EAR DRY DROPSWELL AT WALGREENS HUMAN OTC DRUG LABEL 1 0363-3019 LIQUID 95.00 1 AURICULAR (OTIC) OTC monograph final 11 sections
Walgreens 70% Isopropyl Alcohol Wipes HUMAN OTC DRUG LABEL 1 0363-6505 CLOTH 70 mL TOPICAL OTC monograph not final 13 sections
HUMCO Ear Drops for Swimmers HUMAN OTC DRUG LABEL 1 0395-0098 LIQUID 950 mg AURICULAR (OTIC) OTC monograph final 14 sections
HUMCO Ear Drops for Swimmers HUMAN OTC DRUG LABEL 1 0395-0098 LIQUID 950 mg AURICULAR (OTIC) OTC monograph final 14 sections
HUMCO 1 Percent Iodine HUMAN OTC DRUG LABEL 1 0395-1211 LIQUID 700 mg TOPICAL OTC monograph not final 11 sections
HUMCO Isopropyl Rubbing Alcohol 70% HUMAN OTC DRUG LABEL 1 0395-1249 LIQUID 700 mg TOPICAL OTC monograph not final 13 sections
HUMCO Isopropyl Rubbing Alcohol 70% HUMAN OTC DRUG LABEL 1 0395-1249 LIQUID 700 mg TOPICAL OTC monograph not final 13 sections
HUMCO Isopropyl Rubbing Alcohol 70% Professional Pack HUMAN OTC DRUG LABEL 1 0395-4202 LIQUID 700 mg TOPICAL OTC monograph not final 13 sections
HUMCO Isopropyl Rubbing Alcohol 70% Professional Pack HUMAN OTC DRUG LABEL 1 0395-4202 LIQUID 700 mg TOPICAL OTC monograph not final 13 sections
Ear Drops for Swimmers HUMAN OTC DRUG LABEL 1 0395-9103 LIQUID 950 mg AURICULAR (OTIC) OTC monograph final 15 sections
Isopropyl Alcohol 91 Percent HUMAN OTC DRUG LABEL 1 0395-9119 LIQUID 910 mg TOPICAL OTC monograph not final 13 sections
Isopropyl Rubbing Alcohol 70 Percent HUMAN OTC DRUG LABEL 1 0395-9120 LIQUID 700 mg TOPICAL OTC monograph not final 13 sections
Isopropyl Alcohol 70 Percent With Wintergreen Oil HUMAN OTC DRUG LABEL 1 0395-9121 LIQUID 700 mg TOPICAL OTC monograph not final 13 sections
Isopropyl Rubbing Alcohol HUMAN OTC DRUG LABEL 1 0404-0002 SOLUTION 700 mg TOPICAL OTC MONOGRAPH NOT FINAL 14 sections
Alcohol Prep Pads HUMAN OTC DRUG LABEL 1 0404-0007 SWAB 70 mL TOPICAL OTC monograph not final 11 sections
Alcohol Prep Pads HUMAN OTC DRUG LABEL 1 0404-0103 SWAB 70 mL TOPICAL OTC monograph not final 9 sections
Alcohol Prep Pad Large Pad HUMAN OTC DRUG LABEL 1 0404-9406 CLOTH 0.70 mL TOPICAL OTC monograph not final 10 sections
Alcohol Prep Pad Medium Pad HUMAN OTC DRUG LABEL 1 0404-9407 CLOTH 0.70 mL TOPICAL OTC monograph not final 10 sections
Alcohol Prep Pad Medium Pad HUMAN OTC DRUG LABEL 1 0404-9408 CLOTH 70 mL TOPICAL OTC monograph not final 10 sections
ISOPROPYL ALCOHOL ANTISEPTIC HAND SANITIZER NON-STERILE HUMAN OTC DRUG LABEL 1 0406-4020 SOLUTION 75 mL TOPICAL OTC MONOGRAPH NOT FINAL 13 sections