Stem definition | Drug id | CAS RN |
---|---|---|
antineoplastic agents, platinum derivatives | 4210 | 61825-94-3 |
Molecule | Description |
---|---|
Synonyms:
|
An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS.
|
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 6 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 8.13 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Vd (Volume of distribution) | 0.50 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.10 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.13 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 58.92 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 9, 2002 | FDA | ||
March 18, 2005 | PMDA | Yakult Honsha |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neuropathy peripheral | 1132.01 | 17.02 | 909 | 58826 | 101984 | 56130348 |
Neutropenia | 985.52 | 17.02 | 1015 | 58720 | 157152 | 56075180 |
Laryngospasm | 983.73 | 17.02 | 279 | 59456 | 2605 | 56229727 |
Thrombocytopenia | 734.21 | 17.02 | 810 | 58925 | 135414 | 56096918 |
Disease progression | 718.33 | 17.02 | 710 | 59025 | 104463 | 56127869 |
Neurotoxicity | 697.99 | 17.02 | 339 | 59396 | 15456 | 56216876 |
Diarrhoea | 586.32 | 17.02 | 1738 | 57997 | 636769 | 55595563 |
Mucosal inflammation | 499.25 | 17.02 | 392 | 59343 | 42418 | 56189914 |
Palmar-plantar erythrodysaesthesia syndrome | 440.60 | 17.02 | 276 | 59459 | 20789 | 56211543 |
Paraesthesia | 434.76 | 17.02 | 610 | 59125 | 129904 | 56102428 |
Vomiting | 406.10 | 17.02 | 1303 | 58432 | 496925 | 55735407 |
Myelosuppression | 330.95 | 17.02 | 215 | 59520 | 17240 | 56215092 |
Bone marrow failure | 329.63 | 17.02 | 259 | 59476 | 28027 | 56204305 |
Dysarthria | 322.77 | 17.02 | 295 | 59440 | 39255 | 56193077 |
Stridor | 322.11 | 17.02 | 124 | 59611 | 3171 | 56229161 |
Peripheral sensory neuropathy | 315.34 | 17.02 | 152 | 59583 | 6804 | 56225528 |
Dermatitis acneiform | 308.86 | 17.02 | 130 | 59605 | 4214 | 56228118 |
Polyneuropathy | 293.18 | 17.02 | 179 | 59556 | 12871 | 56219461 |
Drug ineffective | 286.80 | 17.02 | 334 | 59401 | 918655 | 55313677 |
Throat tightness | 284.70 | 17.02 | 216 | 59519 | 22191 | 56210141 |
Arthralgia | 284.03 | 17.02 | 90 | 59645 | 501579 | 55730753 |
Bronchospasm | 282.42 | 17.02 | 187 | 59548 | 15482 | 56216850 |
Arteriospasm coronary | 265.51 | 17.02 | 111 | 59624 | 3536 | 56228796 |
Skin toxicity | 264.61 | 17.02 | 115 | 59620 | 4038 | 56228294 |
Dysaesthesia pharynx | 249.56 | 17.02 | 52 | 59683 | 97 | 56232235 |
Colorectal cancer metastatic | 249.45 | 17.02 | 73 | 59662 | 768 | 56231564 |
Metastases to liver | 243.62 | 17.02 | 194 | 59541 | 21392 | 56210940 |
Joint swelling | 242.01 | 17.02 | 17 | 59718 | 289783 | 55942549 |
Nausea | 241.95 | 17.02 | 1507 | 58228 | 762671 | 55469661 |
Febrile neutropenia | 210.49 | 17.02 | 391 | 59344 | 105154 | 56127178 |
Haematotoxicity | 206.45 | 17.02 | 122 | 59613 | 8261 | 56224071 |
Gastrointestinal toxicity | 204.41 | 17.02 | 109 | 59626 | 6047 | 56226285 |
Pain | 197.79 | 17.02 | 249 | 59486 | 662935 | 55569397 |
Arthropathy | 193.00 | 17.02 | 4 | 59731 | 200271 | 56032061 |
Leukopenia | 190.48 | 17.02 | 300 | 59435 | 70640 | 56161692 |
Gastrointestinal perforation | 185.77 | 17.02 | 83 | 59652 | 3116 | 56229216 |
Malignant neoplasm progression | 184.99 | 17.02 | 302 | 59433 | 73285 | 56159047 |
Headache | 180.39 | 17.02 | 197 | 59538 | 558847 | 55673485 |
Swelling | 179.03 | 17.02 | 22 | 59713 | 239749 | 55992583 |
Enteritis | 177.24 | 17.02 | 106 | 59629 | 7337 | 56224995 |
Product dose omission issue | 176.85 | 17.02 | 10 | 59725 | 204743 | 56027589 |
Sinusitis | 175.88 | 17.02 | 8 | 59727 | 197573 | 56034759 |
Neutrophil count decreased | 174.73 | 17.02 | 239 | 59496 | 49583 | 56182749 |
Posterior reversible encephalopathy syndrome | 172.77 | 17.02 | 140 | 59595 | 15820 | 56216512 |
Systemic lupus erythematosus | 168.17 | 17.02 | 5 | 59730 | 180073 | 56052259 |
Contraindicated product administered | 167.60 | 17.02 | 7 | 59728 | 186279 | 56046053 |
Non-cirrhotic portal hypertension | 163.34 | 17.02 | 38 | 59697 | 142 | 56232190 |
Portal hypertension | 162.37 | 17.02 | 78 | 59657 | 3463 | 56228869 |
Erythema | 156.41 | 17.02 | 440 | 59295 | 155499 | 56076833 |
Dyspnoea | 156.21 | 17.02 | 1118 | 58617 | 591459 | 55640873 |
Nasopharyngitis | 156.14 | 17.02 | 24 | 59711 | 220935 | 56011397 |
Weight increased | 153.40 | 17.02 | 29 | 59706 | 229674 | 56002658 |
Pemphigus | 152.00 | 17.02 | 3 | 59732 | 157209 | 56075123 |
Dehydration | 146.59 | 17.02 | 435 | 59300 | 158390 | 56073942 |
Maternal exposure during pregnancy | 142.43 | 17.02 | 17 | 59718 | 189536 | 56042796 |
Glossodynia | 139.61 | 17.02 | 5 | 59730 | 152453 | 56079879 |
Anaphylactic shock | 139.25 | 17.02 | 142 | 59593 | 21598 | 56210734 |
Abdominal discomfort | 134.58 | 17.02 | 63 | 59672 | 277211 | 55955121 |
Therapeutic product effect decreased | 132.90 | 17.02 | 13 | 59722 | 169439 | 56062893 |
Chills | 132.08 | 17.02 | 318 | 59417 | 102286 | 56130046 |
Abdominal pain | 129.02 | 17.02 | 580 | 59155 | 258225 | 55974107 |
Peripheral swelling | 125.73 | 17.02 | 46 | 59689 | 234680 | 55997652 |
Wound | 125.55 | 17.02 | 5 | 59730 | 138799 | 56093533 |
Venoocclusive liver disease | 123.92 | 17.02 | 70 | 59665 | 4351 | 56227981 |
Ascites | 122.50 | 17.02 | 174 | 59561 | 37370 | 56194962 |
Fall | 120.67 | 17.02 | 121 | 59614 | 357389 | 55874943 |
Paronychia | 119.59 | 17.02 | 71 | 59664 | 4847 | 56227485 |
Laryngeal oedema | 117.11 | 17.02 | 72 | 59663 | 5238 | 56227094 |
Product use issue | 116.95 | 17.02 | 27 | 59708 | 186014 | 56046318 |
Hyperammonaemia | 114.12 | 17.02 | 69 | 59666 | 4871 | 56227461 |
Depression | 111.52 | 17.02 | 27 | 59708 | 180090 | 56052242 |
Anaemia | 109.82 | 17.02 | 567 | 59168 | 266944 | 55965388 |
Dysphonia | 109.23 | 17.02 | 175 | 59560 | 41772 | 56190560 |
Splenomegaly | 107.53 | 17.02 | 88 | 59647 | 10080 | 56222252 |
Insomnia | 107.21 | 17.02 | 35 | 59700 | 191825 | 56040507 |
Immune thrombocytopenia | 105.37 | 17.02 | 85 | 59650 | 9540 | 56222792 |
Dysaesthesia | 104.23 | 17.02 | 61 | 59674 | 4055 | 56228277 |
Hypomagnesaemia | 103.17 | 17.02 | 130 | 59605 | 24885 | 56207447 |
Asthma | 102.19 | 17.02 | 4 | 59731 | 112766 | 56119566 |
Paraesthesia oral | 101.04 | 17.02 | 99 | 59636 | 14350 | 56217982 |
Lower respiratory tract infection | 100.96 | 17.02 | 5 | 59730 | 114789 | 56117543 |
Cardiotoxicity | 99.91 | 17.02 | 75 | 59660 | 7575 | 56224757 |
Intestinal perforation | 99.75 | 17.02 | 87 | 59648 | 10872 | 56221460 |
Drug intolerance | 99.59 | 17.02 | 81 | 59654 | 264737 | 55967595 |
Asthenia | 96.94 | 17.02 | 659 | 59076 | 342314 | 55890018 |
Speech disorder | 95.68 | 17.02 | 155 | 59580 | 37338 | 56194994 |
Focal nodular hyperplasia | 94.39 | 17.02 | 31 | 59704 | 490 | 56231842 |
Tongue oedema | 92.83 | 17.02 | 56 | 59679 | 3936 | 56228396 |
Metastases to lung | 92.79 | 17.02 | 86 | 59649 | 11632 | 56220700 |
Bronchitis | 92.44 | 17.02 | 7 | 59728 | 112304 | 56120028 |
Therapy partial responder | 92.18 | 17.02 | 72 | 59663 | 7713 | 56224619 |
Intestinal obstruction | 90.30 | 17.02 | 129 | 59606 | 27842 | 56204490 |
Hypokalaemia | 90.23 | 17.02 | 262 | 59473 | 94175 | 56138157 |
Pericarditis | 89.06 | 17.02 | 7 | 59728 | 108916 | 56123416 |
Decreased appetite | 87.36 | 17.02 | 461 | 59274 | 218770 | 56013562 |
Large intestine perforation | 87.36 | 17.02 | 70 | 59665 | 7781 | 56224551 |
Anastomotic leak | 86.30 | 17.02 | 28 | 59707 | 425 | 56231907 |
Dysphagia | 84.77 | 17.02 | 234 | 59501 | 81713 | 56150619 |
Enterocolitis | 84.76 | 17.02 | 66 | 59669 | 7038 | 56225294 |
Hepatic enzyme increased | 82.99 | 17.02 | 39 | 59696 | 171345 | 56060987 |
Musculoskeletal stiffness | 82.77 | 17.02 | 31 | 59704 | 155976 | 56076356 |
Neuromyotonia | 82.51 | 17.02 | 18 | 59717 | 46 | 56232286 |
Stress cardiomyopathy | 81.61 | 17.02 | 69 | 59666 | 8267 | 56224065 |
Flushing | 80.41 | 17.02 | 208 | 59527 | 69892 | 56162440 |
Metastases to peritoneum | 79.99 | 17.02 | 46 | 59689 | 2958 | 56229374 |
Influenza | 78.22 | 17.02 | 6 | 59729 | 95255 | 56137077 |
Pain in extremity | 77.97 | 17.02 | 122 | 59613 | 297309 | 55935023 |
Exposure during pregnancy | 77.69 | 17.02 | 24 | 59711 | 136318 | 56096014 |
Hyperthermia | 75.87 | 17.02 | 66 | 59669 | 8219 | 56224113 |
Stomatitis | 75.15 | 17.02 | 290 | 59445 | 120520 | 56111812 |
Hyperhidrosis | 74.95 | 17.02 | 245 | 59490 | 93843 | 56138489 |
Alopecia | 74.45 | 17.02 | 123 | 59612 | 293335 | 55938997 |
Nodular regenerative hyperplasia | 73.79 | 17.02 | 25 | 59710 | 437 | 56231895 |
Treatment failure | 73.38 | 17.02 | 45 | 59690 | 170347 | 56061985 |
Contusion | 72.47 | 17.02 | 23 | 59712 | 128407 | 56103925 |
Arthritis | 72.43 | 17.02 | 10 | 59725 | 99842 | 56132490 |
Ileus | 71.83 | 17.02 | 81 | 59654 | 13801 | 56218531 |
Injection site pain | 71.60 | 17.02 | 18 | 59717 | 117100 | 56115232 |
Colon cancer | 71.54 | 17.02 | 68 | 59667 | 9493 | 56222839 |
Condition aggravated | 71.50 | 17.02 | 163 | 59572 | 344735 | 55887597 |
Laryngeal discomfort | 71.29 | 17.02 | 22 | 59713 | 281 | 56232051 |
General physical health deterioration | 70.09 | 17.02 | 361 | 59374 | 169649 | 56062683 |
Platelet count decreased | 69.98 | 17.02 | 260 | 59475 | 106123 | 56126209 |
Oxygen saturation decreased | 69.48 | 17.02 | 213 | 59522 | 78854 | 56153478 |
Neoplasm progression | 69.29 | 17.02 | 123 | 59612 | 31893 | 56200439 |
Hyperammonaemic encephalopathy | 67.82 | 17.02 | 37 | 59698 | 2148 | 56230184 |
Pyrexia | 67.67 | 17.02 | 710 | 59025 | 418063 | 55814269 |
Hospitalisation | 66.80 | 17.02 | 3 | 59732 | 74997 | 56157335 |
Haemolytic anaemia | 65.19 | 17.02 | 65 | 59670 | 9620 | 56222712 |
Helicobacter infection | 65.03 | 17.02 | 3 | 59732 | 73265 | 56159067 |
Drug hypersensitivity | 62.92 | 17.02 | 123 | 59612 | 275082 | 55957250 |
Injection site erythema | 60.53 | 17.02 | 6 | 59729 | 77442 | 56154890 |
Colon cancer metastatic | 60.24 | 17.02 | 28 | 59707 | 1153 | 56231179 |
Interstitial lung disease | 60.04 | 17.02 | 164 | 59571 | 56899 | 56175433 |
Duodenal ulcer perforation | 60.01 | 17.02 | 3 | 59732 | 68339 | 56163993 |
Peritonitis | 58.70 | 17.02 | 79 | 59656 | 16123 | 56216209 |
Adenocarcinoma of colon | 58.08 | 17.02 | 35 | 59700 | 2455 | 56229877 |
Hypertensive crisis | 57.95 | 17.02 | 73 | 59662 | 13963 | 56218369 |
Tumour perforation | 57.82 | 17.02 | 15 | 59720 | 96 | 56232236 |
Anaphylactic reaction | 57.60 | 17.02 | 165 | 59570 | 58830 | 56173502 |
Discomfort | 57.55 | 17.02 | 40 | 59695 | 141721 | 56090611 |
Acute coronary syndrome | 57.50 | 17.02 | 61 | 59674 | 9707 | 56222625 |
Feeling hot | 57.50 | 17.02 | 133 | 59602 | 41654 | 56190678 |
Cardiac failure congestive | 56.56 | 17.02 | 12 | 59723 | 87708 | 56144624 |
Drug abuse | 56.24 | 17.02 | 4 | 59731 | 67606 | 56164726 |
Hypertension | 56.08 | 17.02 | 447 | 59288 | 243831 | 55988501 |
Enterocutaneous fistula | 56.00 | 17.02 | 27 | 59708 | 1208 | 56231124 |
Metastases to meninges | 55.79 | 17.02 | 33 | 59702 | 2237 | 56230095 |
Chemical peritonitis | 53.78 | 17.02 | 14 | 59721 | 91 | 56232241 |
Neutropenic colitis | 52.49 | 17.02 | 34 | 59701 | 2709 | 56229623 |
Extravasation | 52.21 | 17.02 | 31 | 59704 | 2116 | 56230216 |
Hydronephrosis | 51.39 | 17.02 | 56 | 59679 | 9186 | 56223146 |
Injury | 51.38 | 17.02 | 3 | 59732 | 59848 | 56172484 |
Tachycardia | 50.90 | 17.02 | 235 | 59500 | 105641 | 56126691 |
Colitis | 49.94 | 17.02 | 126 | 59609 | 41685 | 56190647 |
Disseminated intravascular coagulation | 49.84 | 17.02 | 77 | 59658 | 17808 | 56214524 |
Suicide attempt | 49.35 | 17.02 | 3 | 59732 | 57833 | 56174499 |
Suicidal ideation | 49.25 | 17.02 | 3 | 59732 | 57739 | 56174593 |
Cholinergic syndrome | 49.11 | 17.02 | 18 | 59717 | 400 | 56231932 |
Somnolence | 48.78 | 17.02 | 61 | 59674 | 163352 | 56068980 |
Varices oesophageal | 48.21 | 17.02 | 33 | 59702 | 2883 | 56229449 |
Blister | 47.92 | 17.02 | 28 | 59707 | 108859 | 56123473 |
Upper respiratory tract infection | 47.53 | 17.02 | 9 | 59726 | 71279 | 56161053 |
Diffuse large B-cell lymphoma recurrent | 47.04 | 17.02 | 27 | 59708 | 1730 | 56230602 |
Dihydropyrimidine dehydrogenase deficiency | 46.92 | 17.02 | 12 | 59723 | 72 | 56232260 |
Gastric varices haemorrhage | 46.84 | 17.02 | 13 | 59722 | 111 | 56232221 |
Choking sensation | 46.69 | 17.02 | 34 | 59701 | 3277 | 56229055 |
Proteinuria | 46.68 | 17.02 | 74 | 59661 | 17496 | 56214836 |
Metastases to ovary | 46.54 | 17.02 | 17 | 59718 | 374 | 56231958 |
Rectal perforation | 46.45 | 17.02 | 17 | 59718 | 376 | 56231956 |
Diffuse large B-cell lymphoma refractory | 46.11 | 17.02 | 23 | 59712 | 1109 | 56231223 |
Blood lactate dehydrogenase abnormal | 45.97 | 17.02 | 15 | 59720 | 232 | 56232100 |
Mobility decreased | 45.67 | 17.02 | 24 | 59711 | 98967 | 56133365 |
Cough | 45.27 | 17.02 | 134 | 59601 | 259827 | 55972505 |
Stress | 44.91 | 17.02 | 5 | 59730 | 58905 | 56173427 |
Evans syndrome | 44.86 | 17.02 | 14 | 59721 | 186 | 56232146 |
Band sensation | 44.85 | 17.02 | 20 | 59715 | 747 | 56231585 |
Sensation of foreign body | 44.26 | 17.02 | 36 | 59699 | 4086 | 56228246 |
Mucosal toxicity | 43.93 | 17.02 | 16 | 59719 | 349 | 56231983 |
Pneumonia | 43.90 | 17.02 | 253 | 59482 | 406845 | 55825487 |
Laryngeal dyspnoea | 43.89 | 17.02 | 13 | 59722 | 143 | 56232189 |
Suffocation feeling | 43.67 | 17.02 | 23 | 59712 | 1243 | 56231089 |
Off label use | 43.00 | 17.02 | 828 | 58907 | 555352 | 55676980 |
Intentional product misuse | 42.97 | 17.02 | 3 | 59732 | 51501 | 56180831 |
Steatohepatitis | 42.84 | 17.02 | 17 | 59718 | 472 | 56231860 |
Overdose | 42.76 | 17.02 | 30 | 59705 | 105800 | 56126532 |
Cataract | 42.71 | 17.02 | 3 | 59732 | 51244 | 56181088 |
Leukoencephalopathy | 42.47 | 17.02 | 35 | 59700 | 4047 | 56228285 |
Hepatic failure | 42.19 | 17.02 | 103 | 59632 | 33383 | 56198949 |
Pancytopenia | 41.96 | 17.02 | 196 | 59539 | 88519 | 56143813 |
Injection site reaction | 41.94 | 17.02 | 4 | 59731 | 53243 | 56179089 |
Drug interaction | 41.90 | 17.02 | 101 | 59634 | 209654 | 56022678 |
Anxiety | 41.85 | 17.02 | 89 | 59646 | 193083 | 56039249 |
Gait disturbance | 41.78 | 17.02 | 68 | 59667 | 163253 | 56069079 |
Neutrophil count abnormal | 41.29 | 17.02 | 29 | 59706 | 2641 | 56229691 |
Cold dysaesthesia | 41.26 | 17.02 | 8 | 59727 | 8 | 56232324 |
Splenic artery thrombosis | 41.14 | 17.02 | 10 | 59725 | 47 | 56232285 |
Carcinoembryonic antigen increased | 41.10 | 17.02 | 24 | 59711 | 1588 | 56230744 |
White blood cell count decreased | 40.91 | 17.02 | 251 | 59484 | 125739 | 56106593 |
Cytokine release syndrome | 40.89 | 17.02 | 54 | 59681 | 10821 | 56221511 |
Osteoporosis | 40.76 | 17.02 | 4 | 59731 | 52048 | 56180284 |
Factor VII deficiency | 40.71 | 17.02 | 9 | 59726 | 25 | 56232307 |
Breast cancer | 40.29 | 17.02 | 3 | 59732 | 48830 | 56183502 |
Migraine | 40.10 | 17.02 | 21 | 59714 | 86776 | 56145556 |
Metastases to spleen | 39.88 | 17.02 | 12 | 59723 | 140 | 56232192 |
Tremor | 39.80 | 17.02 | 242 | 59493 | 120847 | 56111485 |
Acute polyneuropathy | 39.15 | 17.02 | 13 | 59722 | 213 | 56232119 |
Infusion related hypersensitivity reaction | 38.83 | 17.02 | 12 | 59723 | 154 | 56232178 |
Cystitis radiation | 38.82 | 17.02 | 10 | 59725 | 62 | 56232270 |
Large intestinal obstruction | 38.75 | 17.02 | 25 | 59710 | 1978 | 56230354 |
Type 2 diabetes mellitus | 38.32 | 17.02 | 3 | 59732 | 46859 | 56185473 |
Pharyngeal dyskinesia | 38.20 | 17.02 | 9 | 59726 | 36 | 56232296 |
Hypertrichosis | 38.20 | 17.02 | 20 | 59715 | 1068 | 56231264 |
Multiple organ dysfunction syndrome | 38.10 | 17.02 | 133 | 59602 | 52637 | 56179695 |
Oropharyngeal discomfort | 37.73 | 17.02 | 34 | 59701 | 4434 | 56227898 |
Fatigue | 37.68 | 17.02 | 600 | 59135 | 787952 | 55444380 |
Bladder tamponade | 37.65 | 17.02 | 10 | 59725 | 71 | 56232261 |
Pharyngeal paraesthesia | 37.52 | 17.02 | 23 | 59712 | 1664 | 56230668 |
Thrombocytopenic purpura | 37.17 | 17.02 | 21 | 59714 | 1305 | 56231027 |
Cardiac ventricular thrombosis | 37.12 | 17.02 | 16 | 59719 | 550 | 56231782 |
Short-bowel syndrome | 36.96 | 17.02 | 15 | 59720 | 442 | 56231890 |
Chronic obstructive pulmonary disease | 36.71 | 17.02 | 8 | 59727 | 57407 | 56174925 |
Folliculitis | 36.52 | 17.02 | 7 | 59728 | 54972 | 56177360 |
Infection | 36.45 | 17.02 | 101 | 59634 | 200105 | 56032227 |
Hypertransaminasaemia | 36.21 | 17.02 | 34 | 59701 | 4673 | 56227659 |
Paralysis | 35.75 | 17.02 | 46 | 59689 | 8986 | 56223346 |
Memory impairment | 35.68 | 17.02 | 24 | 59711 | 86533 | 56145799 |
Muscle rigidity | 35.59 | 17.02 | 50 | 59685 | 10621 | 56221711 |
Atypical haemolytic uraemic syndrome | 35.38 | 17.02 | 16 | 59719 | 618 | 56231714 |
Formication | 35.09 | 17.02 | 31 | 59704 | 3939 | 56228393 |
Ileal perforation | 35.00 | 17.02 | 14 | 59721 | 397 | 56231935 |
COVID-19 | 34.91 | 17.02 | 18 | 59717 | 75040 | 56157292 |
Incorrect dose administered | 34.26 | 17.02 | 7 | 59728 | 52540 | 56179792 |
Metastasis | 33.86 | 17.02 | 33 | 59702 | 4751 | 56227581 |
ECG signs of myocardial ischaemia | 33.75 | 17.02 | 9 | 59726 | 65 | 56232267 |
Injection site pruritus | 33.42 | 17.02 | 3 | 59732 | 41928 | 56190404 |
Sleep disorder | 33.34 | 17.02 | 15 | 59720 | 67648 | 56164684 |
Inappropriate schedule of product administration | 33.21 | 17.02 | 24 | 59711 | 83363 | 56148969 |
Hypoalbuminaemia | 32.91 | 17.02 | 48 | 59687 | 10551 | 56221781 |
Myalgia | 32.81 | 17.02 | 56 | 59679 | 131969 | 56100363 |
Abortion spontaneous | 32.64 | 17.02 | 4 | 59731 | 43749 | 56188583 |
Muscle spasms | 32.36 | 17.02 | 253 | 59482 | 137118 | 56095214 |
Anastomotic fistula | 32.34 | 17.02 | 7 | 59728 | 17 | 56232315 |
Respiratory distress | 32.30 | 17.02 | 90 | 59645 | 31577 | 56200755 |
Female genital tract fistula | 31.82 | 17.02 | 31 | 59704 | 4461 | 56227871 |
Type I hypersensitivity | 31.70 | 17.02 | 24 | 59711 | 2454 | 56229878 |
Peripheral motor neuropathy | 31.63 | 17.02 | 20 | 59715 | 1528 | 56230804 |
Tumour ulceration | 31.56 | 17.02 | 10 | 59725 | 140 | 56232192 |
Ocular toxicity | 31.47 | 17.02 | 15 | 59720 | 654 | 56231678 |
Gastric perforation | 31.28 | 17.02 | 20 | 59715 | 1558 | 56230774 |
Haemolysis | 31.17 | 17.02 | 36 | 59699 | 6292 | 56226040 |
Motion sickness | 31.11 | 17.02 | 16 | 59719 | 823 | 56231509 |
Catheter site bruise | 30.62 | 17.02 | 12 | 59723 | 322 | 56232010 |
Vascular pain | 30.58 | 17.02 | 15 | 59720 | 697 | 56231635 |
Perforation | 30.50 | 17.02 | 17 | 59718 | 1029 | 56231303 |
Nicotinic acid deficiency | 30.35 | 17.02 | 8 | 59727 | 55 | 56232277 |
Tumour necrosis | 29.98 | 17.02 | 15 | 59720 | 728 | 56231604 |
Hyperpyrexia | 29.85 | 17.02 | 26 | 59709 | 3242 | 56229090 |
Rectal cancer | 29.79 | 17.02 | 21 | 59714 | 1924 | 56230408 |
Metastases to lymph nodes | 29.68 | 17.02 | 38 | 59697 | 7385 | 56224947 |
Dysgeusia | 29.43 | 17.02 | 103 | 59632 | 40812 | 56191520 |
Blood pressure fluctuation | 29.36 | 17.02 | 4 | 59731 | 40356 | 56191976 |
Paraphilia | 29.25 | 17.02 | 5 | 59730 | 0 | 56232332 |
Rectal cancer recurrent | 29.14 | 17.02 | 7 | 59728 | 31 | 56232301 |
Hemiparesis | 29.12 | 17.02 | 68 | 59667 | 21422 | 56210910 |
Pulmonary embolism | 29.04 | 17.02 | 204 | 59531 | 106920 | 56125412 |
Hemiparaesthesia | 28.75 | 17.02 | 8 | 59727 | 69 | 56232263 |
Inflammation | 28.67 | 17.02 | 19 | 59716 | 69052 | 56163280 |
Wrong technique in product usage process | 28.50 | 17.02 | 13 | 59722 | 58155 | 56174177 |
Congestive cardiomyopathy | 28.49 | 17.02 | 33 | 59702 | 5786 | 56226546 |
Hypophagia | 28.40 | 17.02 | 81 | 59654 | 28795 | 56203537 |
Cyanosis | 28.29 | 17.02 | 56 | 59679 | 15754 | 56216578 |
Anaphylactoid reaction | 28.28 | 17.02 | 26 | 59709 | 3480 | 56228852 |
Subileus | 28.06 | 17.02 | 24 | 59711 | 2920 | 56229412 |
Mucosal necrosis | 27.96 | 17.02 | 7 | 59728 | 38 | 56232294 |
Trismus | 27.95 | 17.02 | 26 | 59709 | 3532 | 56228800 |
Haemolytic uraemic syndrome | 27.92 | 17.02 | 22 | 59713 | 2386 | 56229946 |
Tonic clonic movements | 27.44 | 17.02 | 17 | 59718 | 1253 | 56231079 |
K-ras gene mutation | 27.32 | 17.02 | 6 | 59729 | 16 | 56232316 |
Left ventricular failure | 27.30 | 17.02 | 30 | 59705 | 4966 | 56227366 |
Inferior vena cava stenosis | 27.05 | 17.02 | 6 | 59729 | 17 | 56232315 |
Feeling abnormal | 26.92 | 17.02 | 64 | 59671 | 133538 | 56098794 |
Medical device site extravasation | 26.90 | 17.02 | 5 | 59730 | 3 | 56232329 |
Administration site extravasation | 26.77 | 17.02 | 14 | 59721 | 746 | 56231586 |
White blood cell count abnormal | 26.62 | 17.02 | 32 | 59703 | 5835 | 56226497 |
Hepatic function abnormal | 26.61 | 17.02 | 89 | 59646 | 34469 | 56197863 |
Cardiospasm | 26.55 | 17.02 | 6 | 59729 | 19 | 56232313 |
Lip oedema | 26.52 | 17.02 | 25 | 59710 | 3453 | 56228879 |
Skin fissures | 26.37 | 17.02 | 41 | 59694 | 9532 | 56222800 |
Impaired healing | 26.34 | 17.02 | 32 | 59703 | 86809 | 56145523 |
Herpes zoster | 26.31 | 17.02 | 25 | 59710 | 75864 | 56156468 |
Palmar erythema | 25.93 | 17.02 | 18 | 59717 | 1609 | 56230723 |
Cholangitis | 25.81 | 17.02 | 29 | 59706 | 4920 | 56227412 |
Schistosomiasis | 25.79 | 17.02 | 5 | 59730 | 5 | 56232327 |
Haematemesis | 25.73 | 17.02 | 78 | 59657 | 28680 | 56203652 |
Autoimmune haemolytic anaemia | 25.70 | 17.02 | 27 | 59708 | 4249 | 56228083 |
Catabolic state | 25.52 | 17.02 | 7 | 59728 | 57 | 56232275 |
Thrombotic microangiopathy | 25.50 | 17.02 | 40 | 59695 | 9371 | 56222961 |
Hypotension | 25.44 | 17.02 | 390 | 59345 | 250118 | 55982214 |
Confusional state | 25.37 | 17.02 | 124 | 59611 | 208031 | 56024301 |
Rhabdomyolysis | 25.32 | 17.02 | 6 | 59729 | 40652 | 56191680 |
Aortic intramural haematoma | 25.10 | 17.02 | 7 | 59728 | 61 | 56232271 |
Influenza like illness | 25.01 | 17.02 | 17 | 59718 | 60971 | 56171361 |
Hepatocellular injury | 24.75 | 17.02 | 73 | 59662 | 26441 | 56205891 |
Small intestinal obstruction | 24.75 | 17.02 | 55 | 59680 | 16770 | 56215562 |
Adverse event | 24.70 | 17.02 | 14 | 59721 | 55362 | 56176970 |
Loss of personal independence in daily activities | 24.66 | 17.02 | 30 | 59705 | 81339 | 56150993 |
Gastrointestinal anastomotic leak | 24.64 | 17.02 | 9 | 59726 | 198 | 56232134 |
Urinary tract infection | 24.54 | 17.02 | 152 | 59583 | 240361 | 55991971 |
Chest discomfort | 24.35 | 17.02 | 184 | 59551 | 98673 | 56133659 |
Ileus paralytic | 24.34 | 17.02 | 26 | 59709 | 4169 | 56228163 |
Monoparesis | 24.29 | 17.02 | 17 | 59718 | 1539 | 56230793 |
Treatment noncompliance | 24.29 | 17.02 | 3 | 59732 | 32620 | 56199712 |
Metastases to diaphragm | 24.22 | 17.02 | 6 | 59729 | 31 | 56232301 |
Gastrointestinal stoma complication | 24.11 | 17.02 | 17 | 59718 | 1558 | 56230774 |
Sedation | 24.10 | 17.02 | 4 | 59731 | 34850 | 56197482 |
Biliary tract infection | 24.09 | 17.02 | 12 | 59723 | 577 | 56231755 |
Metastases to bone marrow | 24.08 | 17.02 | 10 | 59725 | 313 | 56232019 |
Soft tissue necrosis | 23.99 | 17.02 | 11 | 59724 | 439 | 56231893 |
Productive cough | 23.98 | 17.02 | 15 | 59720 | 56217 | 56176115 |
Type II hypersensitivity | 23.77 | 17.02 | 5 | 59730 | 10 | 56232322 |
Granulocyte count decreased | 23.75 | 17.02 | 14 | 59721 | 943 | 56231389 |
Tachypnoea | 23.33 | 17.02 | 51 | 59684 | 15379 | 56216953 |
Myopathy toxic | 23.26 | 17.02 | 11 | 59724 | 471 | 56231861 |
Adverse drug reaction | 23.12 | 17.02 | 21 | 59714 | 65111 | 56167221 |
Renal tubular disorder | 23.02 | 17.02 | 20 | 59715 | 2486 | 56229846 |
Hypocapnia | 22.93 | 17.02 | 10 | 59725 | 354 | 56231978 |
Nasal congestion | 22.73 | 17.02 | 16 | 59719 | 56354 | 56175978 |
Portal shunt | 22.59 | 17.02 | 5 | 59730 | 14 | 56232318 |
Implant site dehiscence | 22.59 | 17.02 | 5 | 59730 | 14 | 56232318 |
Disease recurrence | 22.57 | 17.02 | 66 | 59669 | 23794 | 56208538 |
Cardiogenic shock | 22.49 | 17.02 | 52 | 59683 | 16273 | 56216059 |
Oesophageal varices haemorrhage | 22.41 | 17.02 | 14 | 59721 | 1047 | 56231285 |
Balance disorder | 22.36 | 17.02 | 29 | 59706 | 76491 | 56155841 |
Colitis ischaemic | 22.33 | 17.02 | 39 | 59696 | 9981 | 56222351 |
Septic shock | 22.18 | 17.02 | 125 | 59610 | 60710 | 56171622 |
Subacute cutaneous lupus erythematosus | 22.09 | 17.02 | 19 | 59716 | 2330 | 56230002 |
Rhinorrhoea | 21.95 | 17.02 | 17 | 59718 | 57020 | 56175312 |
Retching | 21.93 | 17.02 | 46 | 59689 | 13484 | 56218848 |
Skin reaction | 21.86 | 17.02 | 45 | 59690 | 13018 | 56219314 |
Blood phosphorus decreased | 21.84 | 17.02 | 24 | 59711 | 3973 | 56228359 |
Emotional distress | 21.53 | 17.02 | 3 | 59732 | 29760 | 56202572 |
Heart rate decreased | 21.47 | 17.02 | 8 | 59727 | 40419 | 56191913 |
Dizziness | 21.45 | 17.02 | 276 | 59459 | 375864 | 55856468 |
Blood glucose increased | 21.43 | 17.02 | 29 | 59706 | 75122 | 56157210 |
Diabetes mellitus | 21.23 | 17.02 | 15 | 59720 | 52720 | 56179612 |
Lacrimation disorder | 21.16 | 17.02 | 4 | 59731 | 3 | 56232329 |
Hyperventilation | 21.16 | 17.02 | 28 | 59707 | 5620 | 56226712 |
Hypoaesthesia oral | 21.07 | 17.02 | 41 | 59694 | 11390 | 56220942 |
Gastrooesophageal reflux disease | 20.97 | 17.02 | 35 | 59700 | 83222 | 56149110 |
Eyelid ptosis | 20.94 | 17.02 | 30 | 59705 | 6489 | 56225843 |
Dry eye | 20.85 | 17.02 | 6 | 59729 | 35710 | 56196622 |
Hepatic encephalopathy | 20.79 | 17.02 | 38 | 59697 | 10072 | 56222260 |
Respiratory failure | 20.70 | 17.02 | 172 | 59563 | 94890 | 56137442 |
Respiratory fatigue | 20.68 | 17.02 | 7 | 59728 | 122 | 56232210 |
Post embolisation syndrome | 20.63 | 17.02 | 4 | 59731 | 4 | 56232328 |
Dyslalia | 20.58 | 17.02 | 10 | 59725 | 455 | 56231877 |
Coronary artery disease | 20.29 | 17.02 | 4 | 59731 | 30792 | 56201540 |
Encapsulating peritoneal sclerosis | 20.21 | 17.02 | 9 | 59726 | 335 | 56231997 |
Portal vein dilatation | 20.15 | 17.02 | 5 | 59730 | 26 | 56232306 |
Pelvic fluid collection | 20.08 | 17.02 | 12 | 59723 | 829 | 56231503 |
Toxic encephalopathy | 20.07 | 17.02 | 28 | 59707 | 5910 | 56226422 |
Jaw operation | 20.03 | 17.02 | 12 | 59723 | 833 | 56231499 |
Reticulocytosis | 19.93 | 17.02 | 7 | 59728 | 137 | 56232195 |
Xerosis | 19.86 | 17.02 | 11 | 59724 | 658 | 56231674 |
Drug reaction with eosinophilia and systemic symptoms | 19.83 | 17.02 | 4 | 59731 | 30300 | 56202032 |
Road traffic accident | 19.77 | 17.02 | 3 | 59732 | 27924 | 56204408 |
Encephalopathy | 19.69 | 17.02 | 82 | 59653 | 35243 | 56197089 |
Subclavian vein thrombosis | 19.67 | 17.02 | 16 | 59719 | 1816 | 56230516 |
Colorectal cancer | 19.45 | 17.02 | 21 | 59714 | 3408 | 56228924 |
Bursitis | 19.44 | 17.02 | 3 | 59732 | 27579 | 56204753 |
Oral dysaesthesia | 19.42 | 17.02 | 6 | 59729 | 77 | 56232255 |
Viral infection | 19.34 | 17.02 | 5 | 59730 | 31941 | 56200391 |
Hepatic vein stenosis | 19.14 | 17.02 | 5 | 59730 | 33 | 56232299 |
Sputum abnormal | 19.13 | 17.02 | 10 | 59725 | 532 | 56231800 |
Hyperlipasaemia | 19.08 | 17.02 | 10 | 59725 | 535 | 56231797 |
Temperature intolerance | 18.84 | 17.02 | 32 | 59703 | 8008 | 56224324 |
Red cell fragmentation syndrome | 18.77 | 17.02 | 5 | 59730 | 36 | 56232296 |
Peripheral nerve injury | 18.70 | 17.02 | 9 | 59726 | 401 | 56231931 |
Colorectal cancer recurrent | 18.69 | 17.02 | 4 | 59731 | 9 | 56232323 |
Rectal cancer metastatic | 18.67 | 17.02 | 8 | 59727 | 271 | 56232061 |
Unevaluable event | 18.63 | 17.02 | 14 | 59721 | 47673 | 56184659 |
Stoma site haemorrhage | 18.41 | 17.02 | 12 | 59723 | 966 | 56231366 |
Full blood count abnormal | 18.38 | 17.02 | 3 | 59732 | 26459 | 56205873 |
Hypervolaemia | 18.37 | 17.02 | 3 | 59732 | 26455 | 56205877 |
Tongue discomfort | 18.34 | 17.02 | 16 | 59719 | 2000 | 56230332 |
Trichomegaly | 18.20 | 17.02 | 5 | 59730 | 41 | 56232291 |
Pigmentation disorder | 18.19 | 17.02 | 22 | 59713 | 4037 | 56228295 |
Embolism | 18.18 | 17.02 | 30 | 59705 | 7334 | 56224998 |
Diaphragmatic paralysis | 18.05 | 17.02 | 10 | 59725 | 598 | 56231734 |
Hereditary motor and sensory neuropathy | 18.03 | 17.02 | 6 | 59729 | 99 | 56232233 |
Hyperbilirubinaemia | 18.01 | 17.02 | 36 | 59699 | 10199 | 56222133 |
Aortic thrombosis | 17.98 | 17.02 | 12 | 59723 | 1005 | 56231327 |
Aortitis | 17.89 | 17.02 | 12 | 59723 | 1014 | 56231318 |
Endometrial dysplasia | 17.87 | 17.02 | 4 | 59731 | 12 | 56232320 |
Gastrointestinal inflammation | 17.61 | 17.02 | 24 | 59711 | 4954 | 56227378 |
Appendicitis noninfective | 17.55 | 17.02 | 3 | 59732 | 0 | 56232332 |
Multiple sclerosis | 17.52 | 17.02 | 4 | 59731 | 27798 | 56204534 |
Cold sweat | 17.50 | 17.02 | 37 | 59698 | 10906 | 56221426 |
Femoral artery embolism | 17.49 | 17.02 | 5 | 59730 | 48 | 56232284 |
Duodenal ulcer | 17.46 | 17.02 | 29 | 59706 | 7126 | 56225206 |
Protein urine | 17.45 | 17.02 | 10 | 59725 | 639 | 56231693 |
Femur fracture | 17.43 | 17.02 | 10 | 59725 | 39285 | 56193047 |
Aortic dissection | 17.40 | 17.02 | 15 | 59720 | 1844 | 56230488 |
Acute respiratory distress syndrome | 17.35 | 17.02 | 57 | 59678 | 21869 | 56210463 |
Pulmonary artery thrombosis | 17.30 | 17.02 | 10 | 59725 | 649 | 56231683 |
Hallucination | 17.26 | 17.02 | 16 | 59719 | 49133 | 56183199 |
Cognitive disorder | 17.25 | 17.02 | 16 | 59719 | 49117 | 56183215 |
Metastatic neoplasm | 17.19 | 17.02 | 21 | 59714 | 3892 | 56228440 |
Gastrointestinal stoma output increased | 17.04 | 17.02 | 7 | 59728 | 213 | 56232119 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neuropathy peripheral | 1344.16 | 15.73 | 1295 | 81530 | 74354 | 31540165 |
Disease progression | 790.83 | 15.73 | 1073 | 81752 | 89391 | 31525128 |
Neurotoxicity | 675.37 | 15.73 | 458 | 82367 | 15768 | 31598751 |
Diarrhoea | 645.14 | 15.73 | 2198 | 80627 | 350211 | 31264308 |
Neutropenia | 628.43 | 15.73 | 1229 | 81596 | 139135 | 31475384 |
Dermatitis acneiform | 574.26 | 15.73 | 287 | 82538 | 5480 | 31609039 |
Palmar-plantar erythrodysaesthesia syndrome | 569.24 | 15.73 | 405 | 82420 | 15078 | 31599441 |
Skin toxicity | 554.57 | 15.73 | 253 | 82572 | 3906 | 31610613 |
Arteriospasm coronary | 479.48 | 15.73 | 205 | 82620 | 2686 | 31611833 |
Thrombocytopenia | 461.50 | 15.73 | 1096 | 81729 | 141651 | 31472868 |
Metastases to liver | 404.61 | 15.73 | 305 | 82520 | 12422 | 31602097 |
Paronychia | 386.20 | 15.73 | 182 | 82643 | 3036 | 31611483 |
Vomiting | 333.99 | 15.73 | 1310 | 81515 | 222663 | 31391856 |
Erythema | 332.47 | 15.73 | 682 | 82143 | 79723 | 31534796 |
Interstitial lung disease | 307.70 | 15.73 | 565 | 82260 | 60838 | 31553681 |
Peripheral sensory neuropathy | 305.74 | 15.73 | 196 | 82629 | 6119 | 31608400 |
Polyneuropathy | 303.06 | 15.73 | 260 | 82565 | 12762 | 31601757 |
Paraesthesia | 286.05 | 15.73 | 520 | 82305 | 55551 | 31558968 |
Myelosuppression | 278.34 | 15.73 | 263 | 82562 | 14657 | 31599862 |
Nausea | 272.89 | 15.73 | 1548 | 81277 | 306399 | 31308120 |
Venoocclusive liver disease | 263.40 | 15.73 | 190 | 82635 | 7222 | 31607297 |
Chills | 259.46 | 15.73 | 588 | 82237 | 73562 | 31540957 |
Mucosal inflammation | 255.10 | 15.73 | 378 | 82447 | 34049 | 31580470 |
Portal hypertension | 248.44 | 15.73 | 142 | 82683 | 3583 | 31610936 |
Haematotoxicity | 237.87 | 15.73 | 176 | 82649 | 6961 | 31607558 |
Product dose omission issue | 236.52 | 15.73 | 9 | 82816 | 105577 | 31508942 |
Gastrointestinal perforation | 235.67 | 15.73 | 136 | 82689 | 3496 | 31611023 |
Hypersensitivity | 229.25 | 15.73 | 472 | 82353 | 55271 | 31559248 |
Bone marrow failure | 228.62 | 15.73 | 322 | 82503 | 27686 | 31586833 |
Completed suicide | 223.33 | 15.73 | 3 | 82822 | 91511 | 31523008 |
Colorectal cancer metastatic | 218.53 | 15.73 | 91 | 82734 | 1111 | 31613408 |
Drug ineffective | 214.02 | 15.73 | 447 | 82378 | 395126 | 31219393 |
Arthralgia | 208.57 | 15.73 | 68 | 82757 | 151356 | 31463163 |
Gastrointestinal toxicity | 202.55 | 15.73 | 105 | 82720 | 2169 | 31612350 |
Stomatitis | 191.26 | 15.73 | 358 | 82467 | 39080 | 31575439 |
Enteritis | 190.60 | 15.73 | 154 | 82671 | 6945 | 31607574 |
Metastases to lung | 189.54 | 15.73 | 165 | 82660 | 8257 | 31606262 |
Drug interaction | 182.48 | 15.73 | 166 | 82659 | 208377 | 31406142 |
Laryngospasm | 168.96 | 15.73 | 78 | 82747 | 1238 | 31613281 |
Fall | 167.73 | 15.73 | 144 | 82681 | 185945 | 31428574 |
Flushing | 159.36 | 15.73 | 284 | 82541 | 29844 | 31584675 |
Bronchospasm | 156.55 | 15.73 | 160 | 82665 | 9812 | 31604707 |
Focal nodular hyperplasia | 155.87 | 15.73 | 43 | 82782 | 120 | 31614399 |
Cardiotoxicity | 154.26 | 15.73 | 118 | 82707 | 4909 | 31609610 |
Headache | 150.35 | 15.73 | 155 | 82670 | 183497 | 31431022 |
Overdose | 146.40 | 15.73 | 23 | 82802 | 84641 | 31529878 |
Pneumonia | 142.76 | 15.73 | 428 | 82397 | 334884 | 31279635 |
Hypomagnesaemia | 142.17 | 15.73 | 210 | 82615 | 18848 | 31595671 |
Abdominal pain | 139.42 | 15.73 | 750 | 82075 | 145202 | 31469317 |
Decreased appetite | 138.10 | 15.73 | 775 | 82050 | 152442 | 31462077 |
Hyperammonaemic encephalopathy | 135.56 | 15.73 | 80 | 82745 | 2146 | 31612373 |
Carcinoembryonic antigen increased | 127.79 | 15.73 | 52 | 82773 | 596 | 31613923 |
Hyperammonaemia | 126.68 | 15.73 | 112 | 82713 | 5721 | 31608798 |
Dysaesthesia pharynx | 122.55 | 15.73 | 29 | 82796 | 31 | 31614488 |
Skin reaction | 121.41 | 15.73 | 100 | 82725 | 4634 | 31609885 |
Feeling hot | 121.26 | 15.73 | 179 | 82646 | 16054 | 31598465 |
Proteinuria | 119.72 | 15.73 | 181 | 82644 | 16582 | 31597937 |
Cardiac failure congestive | 112.13 | 15.73 | 34 | 82791 | 79353 | 31535166 |
Oxygen saturation decreased | 109.30 | 15.73 | 329 | 82496 | 48786 | 31565733 |
Therapy partial responder | 107.95 | 15.73 | 108 | 82717 | 6454 | 31608065 |
Neutrophil count decreased | 107.25 | 15.73 | 315 | 82510 | 46079 | 31568440 |
Anastomotic leak | 106.36 | 15.73 | 45 | 82780 | 573 | 31613946 |
Dehydration | 106.23 | 15.73 | 601 | 82224 | 118510 | 31496009 |
Pyrexia | 106.23 | 15.73 | 1236 | 81589 | 302604 | 31311915 |
Leukopenia | 105.64 | 15.73 | 362 | 82463 | 57466 | 31557053 |
Colon cancer metastatic | 105.13 | 15.73 | 61 | 82764 | 1584 | 31612935 |
Infusion related reaction | 104.21 | 15.73 | 319 | 82506 | 47736 | 31566783 |
Depression | 103.56 | 15.73 | 54 | 82771 | 90761 | 31523758 |
Ascites | 102.10 | 15.73 | 286 | 82539 | 40727 | 31573792 |
Intravascular haemolysis | 102.09 | 15.73 | 39 | 82786 | 373 | 31614146 |
Insomnia | 100.11 | 15.73 | 62 | 82763 | 94774 | 31519745 |
Enterocolitis | 95.23 | 15.73 | 106 | 82719 | 7168 | 31607351 |
Hospitalisation | 94.57 | 15.73 | 10 | 82815 | 49797 | 31564722 |
Intestinal obstruction | 93.58 | 15.73 | 182 | 82643 | 20428 | 31594091 |
Varices oesophageal | 92.43 | 15.73 | 74 | 82751 | 3292 | 31611227 |
Anxiety | 90.03 | 15.73 | 64 | 82761 | 90969 | 31523550 |
Metastases to peritoneum | 89.05 | 15.73 | 55 | 82770 | 1605 | 31612914 |
Joint swelling | 89.05 | 15.73 | 16 | 82809 | 53415 | 31561104 |
Somnolence | 86.99 | 15.73 | 79 | 82746 | 99366 | 31515153 |
Myalgia | 86.52 | 15.73 | 47 | 82778 | 77211 | 31537308 |
Weight increased | 86.47 | 15.73 | 55 | 82770 | 82892 | 31531627 |
Peripheral swelling | 85.66 | 15.73 | 35 | 82790 | 67830 | 31546689 |
Anastomotic complication | 84.04 | 15.73 | 33 | 82792 | 342 | 31614177 |
Tumour perforation | 81.73 | 15.73 | 30 | 82795 | 254 | 31614265 |
Ileus | 81.47 | 15.73 | 144 | 82681 | 15025 | 31599494 |
Anaphylactic shock | 80.82 | 15.73 | 138 | 82687 | 14007 | 31600512 |
Aggression | 80.72 | 15.73 | 4 | 82821 | 37287 | 31577232 |
Malignant neoplasm progression | 80.11 | 15.73 | 413 | 82412 | 78585 | 31535934 |
Laryngeal discomfort | 79.90 | 15.73 | 27 | 82798 | 174 | 31614345 |
Diffuse large B-cell lymphoma recurrent | 78.71 | 15.73 | 64 | 82761 | 2911 | 31611608 |
Rhabdomyolysis | 78.30 | 15.73 | 34 | 82791 | 63547 | 31550972 |
Toxic leukoencephalopathy | 75.49 | 15.73 | 29 | 82796 | 282 | 31614237 |
Type I hypersensitivity | 75.21 | 15.73 | 43 | 82782 | 1085 | 31613434 |
Influenza | 74.45 | 15.73 | 13 | 82812 | 44312 | 31570207 |
Neoplasm progression | 73.26 | 15.73 | 163 | 82662 | 20109 | 31594410 |
Foetal exposure during pregnancy | 73.18 | 15.73 | 10 | 82815 | 40866 | 31573653 |
Inappropriate schedule of product administration | 73.15 | 15.73 | 21 | 82804 | 50802 | 31563717 |
Stomal varices | 72.31 | 15.73 | 19 | 82806 | 41 | 31614478 |
Confusional state | 71.39 | 15.73 | 151 | 82674 | 133183 | 31481336 |
Injection site pain | 71.06 | 15.73 | 5 | 82820 | 34629 | 31579890 |
Incorrect dose administered | 70.99 | 15.73 | 6 | 82819 | 35746 | 31578773 |
Tumour necrosis | 70.55 | 15.73 | 42 | 82783 | 1145 | 31613374 |
Asthma | 70.48 | 15.73 | 13 | 82812 | 42598 | 31571921 |
Extravasation | 69.64 | 15.73 | 48 | 82777 | 1694 | 31612825 |
Vascular pain | 69.12 | 15.73 | 22 | 82803 | 114 | 31614405 |
Large intestine perforation | 68.60 | 15.73 | 92 | 82733 | 7544 | 31606975 |
Portal shunt | 68.05 | 15.73 | 17 | 82808 | 27 | 31614492 |
Dihydropyrimidine dehydrogenase deficiency | 67.13 | 15.73 | 19 | 82806 | 60 | 31614459 |
Hallucination | 67.11 | 15.73 | 19 | 82806 | 46391 | 31568128 |
Contusion | 67.10 | 15.73 | 5 | 82820 | 33023 | 31581496 |
Peritonitis | 66.73 | 15.73 | 133 | 82692 | 15194 | 31599325 |
Pneumatosis intestinalis | 66.49 | 15.73 | 64 | 82761 | 3647 | 31610872 |
Pain in extremity | 66.13 | 15.73 | 127 | 82698 | 116076 | 31498443 |
Death | 65.48 | 15.73 | 615 | 82210 | 359954 | 31254565 |
Myocardial infarction | 65.43 | 15.73 | 123 | 82702 | 113331 | 31501188 |
Disseminated intravascular coagulation | 65.27 | 15.73 | 157 | 82668 | 20380 | 31594139 |
Non-cirrhotic portal hypertension | 65.27 | 15.73 | 25 | 82800 | 241 | 31614278 |
Rectal perforation | 65.01 | 15.73 | 29 | 82796 | 423 | 31614096 |
Blood glucose increased | 64.34 | 15.73 | 40 | 82785 | 61043 | 31553476 |
Electrocardiogram QT prolonged | 64.11 | 15.73 | 11 | 82814 | 37976 | 31576543 |
Hepatic atrophy | 63.19 | 15.73 | 22 | 82803 | 157 | 31614362 |
Product use issue | 62.85 | 15.73 | 35 | 82790 | 56724 | 31557795 |
Suicidal ideation | 62.65 | 15.73 | 10 | 82815 | 36396 | 31578123 |
Hyperhidrosis | 61.94 | 15.73 | 343 | 82482 | 67050 | 31547469 |
Adenocarcinoma of colon | 61.49 | 15.73 | 58 | 82767 | 3222 | 31611297 |
Metastases to lymph nodes | 60.75 | 15.73 | 65 | 82760 | 4203 | 31610316 |
Memory impairment | 60.20 | 15.73 | 13 | 82812 | 38117 | 31576402 |
Electrocardiogram ST segment elevation | 59.55 | 15.73 | 67 | 82758 | 4584 | 31609935 |
Tumour lysis syndrome | 59.33 | 15.73 | 127 | 82698 | 15258 | 31599261 |
Paraesthesia oral | 59.11 | 15.73 | 60 | 82765 | 3648 | 31610871 |
Hypertransaminasaemia | 58.55 | 15.73 | 64 | 82761 | 4240 | 31610279 |
Coronary artery disease | 57.77 | 15.73 | 24 | 82801 | 46063 | 31568456 |
Palmar erythema | 56.72 | 15.73 | 23 | 82802 | 261 | 31614258 |
Necrotising fasciitis | 56.65 | 15.73 | 57 | 82768 | 3429 | 31611090 |
Rash pustular | 56.17 | 15.73 | 67 | 82758 | 4882 | 31609637 |
Cholinergic syndrome | 56.08 | 15.73 | 27 | 82798 | 473 | 31614046 |
Dysphonia | 55.61 | 15.73 | 148 | 82677 | 20443 | 31594076 |
Febrile neutropenia | 55.21 | 15.73 | 523 | 82302 | 121326 | 31493193 |
Feeling abnormal | 55.13 | 15.73 | 41 | 82784 | 56961 | 31557558 |
Hyperthermia | 55.05 | 15.73 | 96 | 82729 | 9908 | 31604611 |
Agitation | 54.97 | 15.73 | 37 | 82788 | 54132 | 31560387 |
Intestinal perforation | 54.88 | 15.73 | 87 | 82738 | 8302 | 31606217 |
Splenomegaly | 54.76 | 15.73 | 115 | 82710 | 13634 | 31600885 |
Cholangitis | 53.87 | 15.73 | 84 | 82741 | 7902 | 31606617 |
Arthritis | 53.28 | 15.73 | 5 | 82820 | 27380 | 31587139 |
Nodular regenerative hyperplasia | 52.24 | 15.73 | 32 | 82793 | 920 | 31613599 |
Therapeutic product effect decreased | 51.54 | 15.73 | 10 | 82815 | 31612 | 31582907 |
Hiccups | 50.95 | 15.73 | 89 | 82736 | 9198 | 31605321 |
Administration site extravasation | 50.41 | 15.73 | 26 | 82799 | 531 | 31613988 |
Temperature intolerance | 49.95 | 15.73 | 50 | 82775 | 2989 | 31611530 |
Nasopharyngitis | 49.82 | 15.73 | 55 | 82770 | 63190 | 31551329 |
Pain | 49.43 | 15.73 | 286 | 82539 | 186473 | 31428046 |
Rectal cancer | 49.27 | 15.73 | 43 | 82782 | 2158 | 31612361 |
Toxicity to various agents | 49.07 | 15.73 | 276 | 82549 | 181211 | 31433308 |
Pulmonary embolism | 48.89 | 15.73 | 373 | 82452 | 81273 | 31533246 |
Rectal cancer metastatic | 48.78 | 15.73 | 20 | 82805 | 234 | 31614285 |
Drug reaction with eosinophilia and systemic symptoms | 47.87 | 15.73 | 10 | 82815 | 30008 | 31584511 |
Irritability | 47.85 | 15.73 | 3 | 82822 | 22886 | 31591633 |
Colon cancer | 47.85 | 15.73 | 83 | 82742 | 8530 | 31605989 |
Stoma site haemorrhage | 47.68 | 15.73 | 28 | 82797 | 744 | 31613775 |
Gastrointestinal anastomotic leak | 47.60 | 15.73 | 22 | 82803 | 350 | 31614169 |
General physical health deterioration | 47.52 | 15.73 | 479 | 82346 | 112956 | 31501563 |
Recall phenomenon | 47.25 | 15.73 | 25 | 82800 | 539 | 31613980 |
Asthenia | 47.23 | 15.73 | 837 | 81988 | 223918 | 31390601 |
Cellulitis | 47.13 | 15.73 | 34 | 82791 | 47984 | 31566535 |
Unevaluable event | 47.11 | 15.73 | 11 | 82814 | 30564 | 31583955 |
Drug dependence | 47.08 | 15.73 | 3 | 82822 | 22576 | 31591943 |
Chronic obstructive pulmonary disease | 46.98 | 15.73 | 30 | 82795 | 45136 | 31569383 |
Treatment noncompliance | 46.65 | 15.73 | 6 | 82819 | 25678 | 31588841 |
Malignant ascites | 45.72 | 15.73 | 22 | 82803 | 385 | 31614134 |
Transdifferentiation of neoplasm | 45.42 | 15.73 | 14 | 82811 | 64 | 31614455 |
Mucosal toxicity | 45.33 | 15.73 | 19 | 82806 | 236 | 31614283 |
Septic shock | 44.03 | 15.73 | 310 | 82515 | 65848 | 31548671 |
Musculoskeletal stiffness | 43.60 | 15.73 | 27 | 82798 | 41298 | 31573221 |
Prinzmetal angina | 43.52 | 15.73 | 28 | 82797 | 879 | 31613640 |
Hypokalaemia | 42.93 | 15.73 | 263 | 82562 | 53311 | 31561208 |
Dizziness | 42.62 | 15.73 | 325 | 82500 | 198822 | 31415697 |
Splenorenal shunt | 42.59 | 15.73 | 10 | 82815 | 10 | 31614509 |
Periportal sinus dilatation | 42.10 | 15.73 | 11 | 82814 | 23 | 31614496 |
Neutropenic sepsis | 41.90 | 15.73 | 97 | 82728 | 12282 | 31602237 |
Sinusitis | 41.53 | 15.73 | 22 | 82803 | 36674 | 31577845 |
Throat tightness | 41.43 | 15.73 | 73 | 82752 | 7596 | 31606923 |
Condition aggravated | 41.35 | 15.73 | 255 | 82570 | 163754 | 31450765 |
Perforation | 41.30 | 15.73 | 17 | 82808 | 201 | 31614318 |
Drug level increased | 41.16 | 15.73 | 3 | 82822 | 20183 | 31594336 |
Immune thrombocytopenia | 40.97 | 15.73 | 77 | 82748 | 8421 | 31606098 |
Evans syndrome | 40.76 | 15.73 | 18 | 82807 | 256 | 31614263 |
Abnormal behaviour | 39.98 | 15.73 | 7 | 82818 | 23821 | 31590698 |
Wound dehiscence | 39.82 | 15.73 | 45 | 82780 | 3093 | 31611426 |
Cyanosis | 39.77 | 15.73 | 92 | 82733 | 11643 | 31602876 |
Blood pressure fluctuation | 39.67 | 15.73 | 6 | 82819 | 22730 | 31591789 |
Small intestinal obstruction | 39.63 | 15.73 | 100 | 82725 | 13372 | 31601147 |
Noninfective epididymitis | 39.60 | 15.73 | 8 | 82817 | 0 | 31614519 |
Oxygen saturation normal | 39.60 | 15.73 | 8 | 82817 | 0 | 31614519 |
Influenza like illness | 39.49 | 15.73 | 9 | 82816 | 25428 | 31589091 |
Diabetes mellitus | 39.38 | 15.73 | 32 | 82793 | 42524 | 31571995 |
Intestinal ischaemia | 39.28 | 15.73 | 68 | 82757 | 6977 | 31607542 |
Anastomotic fistula | 39.26 | 15.73 | 13 | 82812 | 78 | 31614441 |
Enterovesical fistula | 39.14 | 15.73 | 24 | 82801 | 691 | 31613828 |
Acute coronary syndrome | 38.75 | 15.73 | 96 | 82729 | 12693 | 31601826 |
Psychotic disorder | 38.63 | 15.73 | 6 | 82819 | 22287 | 31592232 |
Colorectal cancer | 38.60 | 15.73 | 55 | 82770 | 4774 | 31609745 |
Chronic kidney disease | 38.44 | 15.73 | 26 | 82799 | 37949 | 31576570 |
Off label use | 38.35 | 15.73 | 1182 | 81643 | 346092 | 31268427 |
Cardiac disorder | 38.17 | 15.73 | 28 | 82797 | 39186 | 31575333 |
Subileus | 38.15 | 15.73 | 43 | 82782 | 2947 | 31611572 |
Large intestinal obstruction | 37.82 | 15.73 | 31 | 82794 | 1426 | 31613093 |
Wrong technique in product usage process | 37.72 | 15.73 | 20 | 82805 | 33323 | 31581196 |
Prostate cancer | 37.72 | 15.73 | 26 | 82799 | 37575 | 31576944 |
Hypercreatinaemia | 37.65 | 15.73 | 15 | 82810 | 162 | 31614357 |
Seizure | 37.61 | 15.73 | 134 | 82691 | 99634 | 31514885 |
Blood pressure immeasurable | 37.51 | 15.73 | 25 | 82800 | 834 | 31613685 |
Abdominal discomfort | 37.25 | 15.73 | 48 | 82777 | 51519 | 31563000 |
Nicotinic acid deficiency | 37.19 | 15.73 | 13 | 82812 | 94 | 31614425 |
Dysaesthesia | 36.94 | 15.73 | 36 | 82789 | 2083 | 31612436 |
COVID-19 | 36.61 | 15.73 | 54 | 82771 | 54767 | 31559752 |
Fluid retention | 36.14 | 15.73 | 10 | 82815 | 24792 | 31589727 |
International normalised ratio increased | 35.97 | 15.73 | 39 | 82786 | 45184 | 31569335 |
Bronchitis | 35.96 | 15.73 | 29 | 82796 | 38688 | 31575831 |
Premature baby | 35.95 | 15.73 | 3 | 82822 | 18063 | 31596456 |
Cytomegalovirus infection | 35.93 | 15.73 | 10 | 82815 | 24697 | 31589822 |
Tumour marker increased | 35.79 | 15.73 | 21 | 82804 | 557 | 31613962 |
Gastric perforation | 35.48 | 15.73 | 37 | 82788 | 2322 | 31612197 |
Type II hypersensitivity | 35.47 | 15.73 | 10 | 82815 | 31 | 31614488 |
Hypertensive crisis | 35.22 | 15.73 | 71 | 82754 | 8176 | 31606343 |
Pseudocirrhosis | 35.05 | 15.73 | 9 | 82816 | 17 | 31614502 |
Herpes zoster | 35.02 | 15.73 | 20 | 82805 | 31973 | 31582546 |
Contraindicated product administered | 35.00 | 15.73 | 5 | 82820 | 19767 | 31594752 |
Liver function test abnormal | 34.80 | 15.73 | 17 | 82808 | 29675 | 31584844 |
Hepatic infarction | 34.77 | 15.73 | 15 | 82810 | 201 | 31614318 |
Blood creatine phosphokinase increased | 34.74 | 15.73 | 35 | 82790 | 41939 | 31572580 |
Anaphylactic reaction | 34.56 | 15.73 | 161 | 82664 | 29392 | 31585127 |
Hypoglycaemia | 34.20 | 15.73 | 50 | 82775 | 50896 | 31563623 |
Acute abdomen | 34.05 | 15.73 | 32 | 82793 | 1769 | 31612750 |
Stridor | 33.85 | 15.73 | 36 | 82789 | 2311 | 31612208 |
Amaurosis fugax | 33.54 | 15.73 | 20 | 82805 | 547 | 31613972 |
Portal venous gas | 33.37 | 15.73 | 17 | 82808 | 338 | 31614181 |
Metastasis | 33.07 | 15.73 | 44 | 82781 | 3580 | 31610939 |
Folliculitis | 32.80 | 15.73 | 47 | 82778 | 4101 | 31610418 |
Portal vein thrombosis | 32.65 | 15.73 | 43 | 82782 | 3464 | 31611055 |
Carbohydrate antigen 19-9 increased | 32.36 | 15.73 | 14 | 82811 | 189 | 31614330 |
Performance status decreased | 32.23 | 15.73 | 45 | 82780 | 3833 | 31610686 |
Cerebrovascular accident | 31.82 | 15.73 | 104 | 82721 | 79380 | 31535139 |
Pelvic abscess | 31.69 | 15.73 | 23 | 82802 | 882 | 31613637 |
Device related infection | 31.46 | 15.73 | 104 | 82721 | 16195 | 31598324 |
Hypervolaemia | 31.42 | 15.73 | 5 | 82820 | 18246 | 31596273 |
Haematoma | 31.18 | 15.73 | 12 | 82813 | 24127 | 31590392 |
Dyspnoea | 31.00 | 15.73 | 1142 | 81683 | 342337 | 31272182 |
Ocular toxicity | 30.91 | 15.73 | 14 | 82811 | 212 | 31614307 |
Lymphangiosis carcinomatosa | 30.58 | 15.73 | 22 | 82803 | 832 | 31613687 |
Leukoencephalopathy | 30.54 | 15.73 | 44 | 82781 | 3858 | 31610661 |
Hypoalbuminaemia | 30.52 | 15.73 | 80 | 82745 | 10948 | 31603571 |
Delirium | 30.49 | 15.73 | 38 | 82787 | 41383 | 31573136 |
Hypovolaemic shock | 30.47 | 15.73 | 58 | 82767 | 6404 | 31608115 |
Encapsulating peritoneal sclerosis | 30.26 | 15.73 | 19 | 82806 | 571 | 31613948 |
Right ventricular ejection fraction decreased | 30.16 | 15.73 | 9 | 82816 | 36 | 31614483 |
Pulmonary toxicity | 30.11 | 15.73 | 52 | 82773 | 5325 | 31609194 |
Biliary fistula | 29.77 | 15.73 | 9 | 82816 | 38 | 31614481 |
Oesophageal haemorrhage | 29.63 | 15.73 | 25 | 82800 | 1198 | 31613321 |
ECG signs of myocardial ischaemia | 29.56 | 15.73 | 13 | 82812 | 183 | 31614336 |
Accidental overdose | 29.49 | 15.73 | 6 | 82819 | 18344 | 31596175 |
Hepatectomy | 29.39 | 15.73 | 10 | 82815 | 66 | 31614453 |
Sciatic nerve palsy | 29.22 | 15.73 | 9 | 82816 | 41 | 31614478 |
Localised infection | 29.13 | 15.73 | 3 | 82822 | 15262 | 31599257 |
Perforation bile duct | 29.08 | 15.73 | 8 | 82817 | 22 | 31614497 |
Blood alkaline phosphatase abnormal | 28.93 | 15.73 | 16 | 82809 | 378 | 31614141 |
Sedation | 28.87 | 15.73 | 7 | 82818 | 18958 | 31595561 |
Hyperkalaemia | 28.77 | 15.73 | 80 | 82745 | 64271 | 31550248 |
Haemorrhage intracranial | 28.71 | 15.73 | 3 | 82822 | 15085 | 31599434 |
Failure to anastomose | 28.40 | 15.73 | 13 | 82812 | 202 | 31614317 |
Medication error | 28.30 | 15.73 | 12 | 82813 | 22760 | 31591759 |
Nasal congestion | 28.27 | 15.73 | 9 | 82816 | 20372 | 31594147 |
Blood cholesterol increased | 28.26 | 15.73 | 5 | 82820 | 16888 | 31597631 |
Blood pressure systolic increased | 28.09 | 15.73 | 8 | 82817 | 19462 | 31595057 |
Oesophageal varices haemorrhage | 28.08 | 15.73 | 36 | 82789 | 2824 | 31611695 |
Haemolytic anaemia | 28.07 | 15.73 | 72 | 82753 | 9724 | 31604795 |
Anaphylactoid reaction | 28.06 | 15.73 | 31 | 82794 | 2078 | 31612441 |
Hyperaemia | 27.99 | 15.73 | 23 | 82802 | 1062 | 31613457 |
Swelling | 27.78 | 15.73 | 34 | 82791 | 37324 | 31577195 |
Head injury | 27.72 | 15.73 | 5 | 82820 | 16653 | 31597866 |
Haemoglobinuria | 27.67 | 15.73 | 18 | 82807 | 576 | 31613943 |
Mobility decreased | 27.54 | 15.73 | 19 | 82806 | 27450 | 31587069 |
Alopecia | 27.40 | 15.73 | 117 | 82708 | 20578 | 31593941 |
Upper respiratory tract infection | 27.37 | 15.73 | 22 | 82803 | 29400 | 31585119 |
Muscular weakness | 27.34 | 15.73 | 84 | 82741 | 65364 | 31549155 |
Hyperbilirubinaemia | 27.34 | 15.73 | 97 | 82728 | 15653 | 31598866 |
Anal sphincter atony | 27.31 | 15.73 | 10 | 82815 | 84 | 31614435 |
Small intestinal perforation | 27.26 | 15.73 | 30 | 82795 | 2002 | 31612517 |
Necrotising oesophagitis | 27.08 | 15.73 | 17 | 82808 | 511 | 31614008 |
Full blood count abnormal | 27.00 | 15.73 | 5 | 82820 | 16342 | 31598177 |
Brain teratoma | 27.00 | 15.73 | 7 | 82818 | 14 | 31614505 |
Emotional distress | 26.94 | 15.73 | 3 | 82822 | 14353 | 31600166 |
Cachexia | 26.75 | 15.73 | 56 | 82769 | 6623 | 31607896 |
Acute respiratory distress syndrome | 26.74 | 15.73 | 131 | 82694 | 24409 | 31590110 |
Pulmonary fibrosis | 26.72 | 15.73 | 100 | 82725 | 16560 | 31597959 |
Vocal cord paralysis | 26.42 | 15.73 | 21 | 82804 | 924 | 31613595 |
Erectile dysfunction | 25.79 | 15.73 | 9 | 82816 | 19226 | 31595293 |
Circulatory collapse | 25.66 | 15.73 | 111 | 82714 | 19633 | 31594886 |
Productive cough | 25.50 | 15.73 | 30 | 82795 | 33510 | 31581009 |
Skin fissures | 25.37 | 15.73 | 43 | 82782 | 4337 | 31610182 |
Basal cell carcinoma | 25.26 | 15.73 | 8 | 82817 | 18171 | 31596348 |
Osteomyelitis | 25.24 | 15.73 | 4 | 82821 | 14639 | 31599880 |
Subdural haematoma | 25.23 | 15.73 | 9 | 82816 | 18962 | 31595557 |
Pruritus | 25.10 | 15.73 | 463 | 82362 | 124704 | 31489815 |
Road traffic accident | 25.02 | 15.73 | 6 | 82819 | 16375 | 31598144 |
Hot flush | 24.97 | 15.73 | 96 | 82729 | 16100 | 31598419 |
Biliary tract infection | 24.96 | 15.73 | 17 | 82808 | 588 | 31613931 |
Gait disturbance | 24.81 | 15.73 | 111 | 82714 | 77384 | 31537135 |
Toxic epidermal necrolysis | 24.73 | 15.73 | 10 | 82815 | 19514 | 31595005 |
Embolism | 24.73 | 15.73 | 57 | 82768 | 7196 | 31607323 |
Ileal perforation | 24.67 | 15.73 | 18 | 82807 | 696 | 31613823 |
Adverse drug reaction | 24.52 | 15.73 | 18 | 82807 | 25183 | 31589336 |
Renal disorder | 24.18 | 15.73 | 16 | 82809 | 23629 | 31590890 |
Aortitis | 24.14 | 15.73 | 14 | 82811 | 363 | 31614156 |
Koebner phenomenon | 23.88 | 15.73 | 8 | 82817 | 50 | 31614469 |
Peripheral sensorimotor neuropathy | 23.85 | 15.73 | 24 | 82801 | 1444 | 31613075 |
Oesophagitis | 23.76 | 15.73 | 79 | 82746 | 12337 | 31602182 |
Perihepatic abscess | 23.66 | 15.73 | 9 | 82816 | 85 | 31614434 |
Cardiac ventricular disorder | 23.63 | 15.73 | 12 | 82813 | 237 | 31614282 |
Pulmonary artery thrombosis | 23.63 | 15.73 | 17 | 82808 | 643 | 31613876 |
Nephrolithiasis | 23.54 | 15.73 | 22 | 82803 | 27317 | 31587202 |
Eosinophilia | 23.42 | 15.73 | 16 | 82809 | 23237 | 31591282 |
Laryngeal oedema | 23.33 | 15.73 | 35 | 82790 | 3182 | 31611337 |
Pulmonary oedema | 23.28 | 15.73 | 51 | 82774 | 44451 | 31570068 |
Adenocarcinoma | 23.27 | 15.73 | 26 | 82799 | 1765 | 31612754 |
Throat irritation | 23.20 | 15.73 | 65 | 82760 | 9249 | 31605270 |
Fistula of small intestine | 22.74 | 15.73 | 14 | 82811 | 406 | 31614113 |
Cold sweat | 22.68 | 15.73 | 64 | 82761 | 9145 | 31605374 |
Blood creatinine increased | 22.67 | 15.73 | 138 | 82687 | 88940 | 31525579 |
Xerosis | 22.36 | 15.73 | 15 | 82810 | 506 | 31614013 |
Interventricular septum rupture | 22.22 | 15.73 | 6 | 82819 | 15 | 31614504 |
Hepatic failure | 22.19 | 15.73 | 154 | 82671 | 32548 | 31581971 |
Cerebral vasoconstriction | 22.19 | 15.73 | 11 | 82814 | 206 | 31614313 |
Onycholysis | 22.15 | 15.73 | 16 | 82809 | 609 | 31613910 |
Muscle contractions involuntary | 22.12 | 15.73 | 25 | 82800 | 1719 | 31612800 |
Liver abscess | 22.09 | 15.73 | 36 | 82789 | 3515 | 31611004 |
Papilloedema | 22.03 | 15.73 | 30 | 82795 | 2496 | 31612023 |
Oropharyngeal pain | 22.02 | 15.73 | 30 | 82795 | 31453 | 31583066 |
Intestinal dilatation | 21.97 | 15.73 | 20 | 82805 | 1061 | 31613458 |
Diffuse large B-cell lymphoma refractory | 21.94 | 15.73 | 20 | 82805 | 1063 | 31613456 |
Gout | 21.92 | 15.73 | 10 | 82815 | 18164 | 31596355 |
Cataract | 21.90 | 15.73 | 18 | 82807 | 23789 | 31590730 |
Product prescribing error | 21.90 | 15.73 | 12 | 82813 | 19630 | 31594889 |
Fingerprint loss | 21.88 | 15.73 | 7 | 82818 | 37 | 31614482 |
Metastases to muscle | 21.86 | 15.73 | 11 | 82814 | 213 | 31614306 |
Labelled drug-drug interaction medication error | 21.79 | 15.73 | 4 | 82821 | 13159 | 31601360 |
Sleep disorder | 21.76 | 15.73 | 22 | 82803 | 26326 | 31588193 |
Metastases to retroperitoneum | 21.72 | 15.73 | 11 | 82814 | 216 | 31614303 |
Astringent therapy | 21.68 | 15.73 | 6 | 82819 | 17 | 31614502 |
Hyperpyrexia | 21.67 | 15.73 | 29 | 82796 | 2372 | 31612147 |
Pachymeningitis | 21.67 | 15.73 | 9 | 82816 | 109 | 31614410 |
Gastric dilatation | 21.65 | 15.73 | 16 | 82809 | 631 | 31613888 |
Wheezing | 21.62 | 15.73 | 38 | 82787 | 35948 | 31578571 |
Neck pain | 21.47 | 15.73 | 17 | 82808 | 22893 | 31591626 |
Rectosigmoid cancer | 21.47 | 15.73 | 10 | 82815 | 162 | 31614357 |
Oesophagobronchial fistula | 21.47 | 15.73 | 10 | 82815 | 162 | 31614357 |
Hyperfibrinolysis | 21.19 | 15.73 | 6 | 82819 | 19 | 31614500 |
Obstruction gastric | 21.13 | 15.73 | 18 | 82807 | 874 | 31613645 |
Tachycardia | 20.92 | 15.73 | 297 | 82528 | 75910 | 31538609 |
Colon cancer recurrent | 20.90 | 15.73 | 9 | 82816 | 120 | 31614399 |
Monocytopenia | 20.90 | 15.73 | 8 | 82817 | 77 | 31614442 |
Portal vein dilatation | 20.82 | 15.73 | 5 | 82820 | 6 | 31614513 |
Injection site erythema | 20.75 | 15.73 | 6 | 82819 | 14456 | 31600063 |
Induration | 20.71 | 15.73 | 18 | 82807 | 898 | 31613621 |
Nephrotic syndrome | 20.62 | 15.73 | 52 | 82773 | 6951 | 31607568 |
Gene mutation | 20.51 | 15.73 | 20 | 82805 | 1158 | 31613361 |
Haemoglobin abnormal | 20.41 | 15.73 | 34 | 82791 | 3381 | 31611138 |
Oedema peripheral | 20.39 | 15.73 | 186 | 82639 | 109653 | 31504866 |
Conjunctivitis | 20.33 | 15.73 | 59 | 82766 | 8564 | 31605955 |
Aortic thrombosis | 20.33 | 15.73 | 16 | 82809 | 694 | 31613825 |
Feeling cold | 20.29 | 15.73 | 63 | 82762 | 9491 | 31605028 |
Laboratory test abnormal | 20.25 | 15.73 | 12 | 82813 | 18802 | 31595717 |
Acral peeling skin syndrome | 20.22 | 15.73 | 7 | 82818 | 49 | 31614470 |
Jaundice | 20.18 | 15.73 | 142 | 82683 | 30145 | 31584374 |
Sarcoidosis | 20.15 | 15.73 | 30 | 82795 | 2709 | 31611810 |
Trismus | 20.12 | 15.73 | 28 | 82797 | 2377 | 31612142 |
Full blood count decreased | 20.11 | 15.73 | 9 | 82816 | 16531 | 31597988 |
Wound infection | 20.03 | 15.73 | 49 | 82776 | 6426 | 31608093 |
Catheter site extravasation | 20.03 | 15.73 | 8 | 82817 | 87 | 31614432 |
Allodynia | 20.03 | 15.73 | 15 | 82810 | 604 | 31613915 |
Mucocutaneous rash | 19.91 | 15.73 | 6 | 82819 | 25 | 31614494 |
Pulmonary hypertension | 19.91 | 15.73 | 14 | 82811 | 20027 | 31594492 |
Pelvic fluid collection | 19.89 | 15.73 | 9 | 82816 | 136 | 31614383 |
Thrombotic thrombocytopenic purpura | 19.82 | 15.73 | 33 | 82792 | 3280 | 31611239 |
Pneumonitis chemical | 19.71 | 15.73 | 9 | 82816 | 139 | 31614380 |
Lower respiratory tract infection | 19.65 | 15.73 | 27 | 82798 | 28210 | 31586309 |
Drug intolerance | 19.52 | 15.73 | 70 | 82755 | 51963 | 31562556 |
Respiratory arrest | 19.41 | 15.73 | 24 | 82801 | 26233 | 31588286 |
Diffuse large B-cell lymphoma | 19.31 | 15.73 | 58 | 82767 | 8583 | 31605936 |
Hand-foot-genital syndrome | 19.28 | 15.73 | 5 | 82820 | 10 | 31614509 |
Ischiorectal hernia | 19.28 | 15.73 | 5 | 82820 | 10 | 31614509 |
Malaise | 19.15 | 15.73 | 576 | 82249 | 167935 | 31446584 |
Hypersplenism | 19.13 | 15.73 | 12 | 82813 | 360 | 31614159 |
Peritoneal haematoma | 19.10 | 15.73 | 7 | 82818 | 59 | 31614460 |
Perineal disorder | 18.89 | 15.73 | 7 | 82818 | 61 | 31614458 |
Angioedema | 18.87 | 15.73 | 37 | 82788 | 33581 | 31580938 |
Cholestasis | 18.76 | 15.73 | 121 | 82704 | 24954 | 31589565 |
Peritoneal lesion | 18.76 | 15.73 | 8 | 82817 | 104 | 31614415 |
Oropharyngeal spasm | 18.73 | 15.73 | 9 | 82816 | 157 | 31614362 |
Heart rate decreased | 18.71 | 15.73 | 28 | 82797 | 28238 | 31586281 |
Shock | 18.65 | 15.73 | 112 | 82713 | 22533 | 31591986 |
Obstructive airways disorder | 18.65 | 15.73 | 5 | 82820 | 12659 | 31601860 |
Underdose | 18.52 | 15.73 | 5 | 82820 | 12602 | 31601917 |
Disease susceptibility | 18.50 | 15.73 | 7 | 82818 | 65 | 31614454 |
Band sensation | 18.49 | 15.73 | 8 | 82817 | 108 | 31614411 |
Peripheral ischaemia | 18.45 | 15.73 | 42 | 82783 | 5258 | 31609261 |
Blood triglycerides increased | 18.43 | 15.73 | 6 | 82819 | 13391 | 31601128 |
Blood pressure increased | 18.42 | 15.73 | 127 | 82698 | 79506 | 31535013 |
Gastrointestinal stoma complication | 18.39 | 15.73 | 19 | 82806 | 1179 | 31613340 |
Appendicitis noninfective | 18.38 | 15.73 | 5 | 82820 | 13 | 31614506 |
Pulmonary infarction | 18.29 | 15.73 | 19 | 82806 | 1187 | 31613332 |
Choking sensation | 18.23 | 15.73 | 18 | 82807 | 1058 | 31613461 |
Gastrointestinal mucosal necrosis | 18.08 | 15.73 | 9 | 82816 | 170 | 31614349 |
Nephritis allergic | 18.01 | 15.73 | 12 | 82813 | 400 | 31614119 |
Balance disorder | 17.88 | 15.73 | 45 | 82780 | 37377 | 31577142 |
Chemical peritonitis | 17.79 | 15.73 | 8 | 82817 | 119 | 31614400 |
Abdominal sepsis | 17.76 | 15.73 | 17 | 82808 | 962 | 31613557 |
Metastases to spleen | 17.72 | 15.73 | 12 | 82813 | 411 | 31614108 |
Blindness transient | 17.66 | 15.73 | 24 | 82801 | 1993 | 31612526 |
Metastases to bone marrow | 17.63 | 15.73 | 13 | 82812 | 511 | 31614008 |
Microangiopathic haemolytic anaemia | 17.54 | 15.73 | 16 | 82809 | 851 | 31613668 |
Product administration error | 17.46 | 15.73 | 9 | 82816 | 15238 | 31599281 |
Neurosarcoidosis | 17.44 | 15.73 | 9 | 82816 | 184 | 31614335 |
Perineal ulceration | 17.39 | 15.73 | 5 | 82820 | 17 | 31614502 |
Blood bilirubin decreased | 17.30 | 15.73 | 11 | 82814 | 338 | 31614181 |
Vascular injury | 17.29 | 15.73 | 10 | 82815 | 258 | 31614261 |
Hypothyroidism | 17.22 | 15.73 | 13 | 82812 | 17934 | 31596585 |
Acute motor-sensory axonal neuropathy | 17.16 | 15.73 | 8 | 82817 | 130 | 31614389 |
Gastrointestinal necrosis | 17.14 | 15.73 | 30 | 82795 | 3104 | 31611415 |
Hypersomnia | 17.13 | 15.73 | 4 | 82821 | 11115 | 31603404 |
Peripheral motor neuropathy | 17.10 | 15.73 | 22 | 82803 | 1732 | 31612787 |
Intrahepatic portal hepatic venous fistula | 17.04 | 15.73 | 4 | 82821 | 4 | 31614515 |
Biliary cancer metastatic | 17.04 | 15.73 | 4 | 82821 | 4 | 31614515 |
Peritoneal disorder | 16.88 | 15.73 | 10 | 82815 | 270 | 31614249 |
Loss of personal independence in daily activities | 16.88 | 15.73 | 30 | 82795 | 28258 | 31586261 |
Hypoaesthesia | 16.87 | 15.73 | 222 | 82603 | 55800 | 31558719 |
Colon cancer stage III | 16.81 | 15.73 | 9 | 82816 | 199 | 31614320 |
Oral dysaesthesia | 16.77 | 15.73 | 7 | 82818 | 86 | 31614433 |
Duodenal stenosis | 16.77 | 15.73 | 9 | 82816 | 200 | 31614319 |
VIth nerve disorder | 16.76 | 15.73 | 5 | 82820 | 20 | 31614499 |
Axonal and demyelinating polyneuropathy | 16.56 | 15.73 | 5 | 82820 | 21 | 31614498 |
Metastases to pelvis | 16.56 | 15.73 | 10 | 82815 | 280 | 31614239 |
Proteus infection | 16.44 | 15.73 | 16 | 82809 | 924 | 31613595 |
Blood glucose decreased | 16.44 | 15.73 | 6 | 82819 | 12465 | 31602054 |
Fistula | 16.34 | 15.73 | 42 | 82783 | 5679 | 31608840 |
Type III immune complex mediated reaction | 16.34 | 15.73 | 10 | 82815 | 287 | 31614232 |
Pancreatitis | 16.33 | 15.73 | 44 | 82781 | 35727 | 31578792 |
Bacterial colitis | 16.33 | 15.73 | 6 | 82819 | 51 | 31614468 |
Hyperlipidaemia | 16.25 | 15.73 | 7 | 82818 | 13153 | 31601366 |
Hypotension | 16.18 | 15.73 | 671 | 82154 | 203947 | 31410572 |
Stevens-Johnson syndrome | 16.14 | 15.73 | 13 | 82812 | 17359 | 31597160 |
Tunnel vision | 16.13 | 15.73 | 12 | 82813 | 478 | 31614041 |
Vascular access site occlusion | 16.03 | 15.73 | 6 | 82819 | 54 | 31614465 |
Rhinorrhoea | 16.02 | 15.73 | 22 | 82803 | 22990 | 31591529 |
Hepatic cancer recurrent | 16.00 | 15.73 | 10 | 82815 | 298 | 31614221 |
Faeces discoloured | 15.99 | 15.73 | 8 | 82817 | 13778 | 31600741 |
Respiratory depression | 15.98 | 15.73 | 9 | 82816 | 14501 | 31600018 |
Electromyogram abnormal | 15.93 | 15.73 | 6 | 82819 | 55 | 31614464 |
Retroperitoneal abscess | 15.89 | 15.73 | 8 | 82817 | 155 | 31614364 |
Ichthyosis | 15.89 | 15.73 | 7 | 82818 | 99 | 31614420 |
Pancreatic carcinoma metastatic | 15.87 | 15.73 | 28 | 82797 | 2916 | 31611603 |
Eczema impetiginous | 15.86 | 15.73 | 5 | 82820 | 25 | 31614494 |
Radiation interaction | 15.86 | 15.73 | 5 | 82820 | 25 | 31614494 |
Skin laceration | 15.85 | 15.73 | 5 | 82820 | 11386 | 31603133 |
Platelet count decreased | 15.80 | 15.73 | 389 | 82436 | 110046 | 31504473 |
Hyperthyroidism | 15.79 | 15.73 | 3 | 82822 | 9628 | 31604891 |
Haematemesis | 15.78 | 15.73 | 118 | 82707 | 25535 | 31588984 |
Rectal obstruction | 15.77 | 15.73 | 4 | 82821 | 7 | 31614512 |
Nail disorder | 15.76 | 15.73 | 22 | 82803 | 1873 | 31612646 |
Prostatic calcification | 15.76 | 15.73 | 7 | 82818 | 101 | 31614418 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neuropathy peripheral | 2642.68 | 15.28 | 2026 | 125262 | 124870 | 70676286 |
Neutropenia | 1522.12 | 15.28 | 2079 | 125209 | 255077 | 70546079 |
Disease progression | 1514.08 | 15.28 | 1625 | 125663 | 155047 | 70646109 |
Neurotoxicity | 1317.21 | 15.28 | 762 | 126526 | 29064 | 70772092 |
Thrombocytopenia | 1147.34 | 15.28 | 1751 | 125537 | 237359 | 70563797 |
Diarrhoea | 1004.77 | 15.28 | 3378 | 123910 | 779963 | 70021193 |
Laryngospasm | 928.07 | 15.28 | 319 | 126969 | 3324 | 70797832 |
Palmar-plantar erythrodysaesthesia syndrome | 918.84 | 15.28 | 609 | 126679 | 29638 | 70771518 |
Dermatitis acneiform | 851.70 | 15.28 | 384 | 126904 | 8561 | 70792595 |
Skin toxicity | 755.93 | 15.28 | 331 | 126957 | 6867 | 70794289 |
Arteriospasm coronary | 724.78 | 15.28 | 305 | 126983 | 5719 | 70795437 |
Paraesthesia | 695.61 | 15.28 | 1065 | 126223 | 144472 | 70656684 |
Mucosal inflammation | 602.28 | 15.28 | 674 | 126614 | 67176 | 70733980 |
Myelosuppression | 590.09 | 15.28 | 465 | 126823 | 29680 | 70771476 |
Peripheral sensory neuropathy | 576.22 | 15.28 | 325 | 126963 | 11785 | 70789371 |
Metastases to liver | 547.46 | 15.28 | 418 | 126870 | 25460 | 70775696 |
Polyneuropathy | 536.48 | 15.28 | 383 | 126905 | 21032 | 70780124 |
Vomiting | 528.64 | 15.28 | 2282 | 125006 | 590829 | 70210327 |
Bone marrow failure | 521.47 | 15.28 | 536 | 126752 | 48474 | 70752682 |
Arthralgia | 519.85 | 15.28 | 132 | 127156 | 503258 | 70297898 |
Venoocclusive liver disease | 468.99 | 15.28 | 272 | 127016 | 10406 | 70790750 |
Paronychia | 449.16 | 15.28 | 230 | 127058 | 6844 | 70794312 |
Erythema | 447.03 | 15.28 | 1057 | 126231 | 198506 | 70602650 |
Bronchospasm | 410.73 | 15.28 | 335 | 126953 | 22457 | 70778699 |
Colorectal cancer metastatic | 409.21 | 15.28 | 145 | 127143 | 1664 | 70799492 |
Chills | 404.43 | 15.28 | 838 | 126450 | 143948 | 70657208 |
Portal hypertension | 369.05 | 15.28 | 196 | 127092 | 6296 | 70794860 |
Headache | 367.86 | 15.28 | 302 | 126986 | 580103 | 70221053 |
Nausea | 365.64 | 15.28 | 2693 | 124595 | 849395 | 69951761 |
Interstitial lung disease | 365.63 | 15.28 | 666 | 126622 | 104019 | 70697137 |
Haematotoxicity | 359.69 | 15.28 | 252 | 127036 | 13422 | 70787734 |
Drug ineffective | 351.38 | 15.28 | 727 | 126561 | 939025 | 69862131 |
Enteritis | 341.09 | 15.28 | 238 | 127050 | 12593 | 70788563 |
Joint swelling | 340.88 | 15.28 | 31 | 127257 | 253180 | 70547976 |
Gastrointestinal toxicity | 340.64 | 15.28 | 185 | 127103 | 6220 | 70794936 |
Product dose omission issue | 330.24 | 15.28 | 14 | 127274 | 217454 | 70583702 |
Gastrointestinal perforation | 327.13 | 15.28 | 173 | 127115 | 5508 | 70795648 |
Dysaesthesia pharynx | 297.10 | 15.28 | 70 | 127218 | 137 | 70801019 |
Neoplasm progression | 289.66 | 15.28 | 381 | 126907 | 44847 | 70756309 |
Fall | 278.69 | 15.28 | 233 | 127055 | 443863 | 70357293 |
Cardiotoxicity | 270.36 | 15.28 | 195 | 127093 | 10875 | 70790281 |
Pain | 268.43 | 15.28 | 448 | 126840 | 628368 | 70172788 |
Metastases to lung | 267.35 | 15.28 | 228 | 127060 | 16256 | 70784900 |
Throat tightness | 264.86 | 15.28 | 273 | 127015 | 24749 | 70776407 |
Stridor | 262.69 | 15.28 | 144 | 127144 | 4932 | 70796224 |
Neutrophil count decreased | 256.22 | 15.28 | 503 | 126785 | 83053 | 70718103 |
Arthropathy | 248.73 | 15.28 | 4 | 127284 | 150053 | 70651103 |
Drug abuse | 243.77 | 15.28 | 4 | 127284 | 147252 | 70653904 |
Leukopenia | 241.04 | 15.28 | 567 | 126721 | 105993 | 70695163 |
Malignant neoplasm progression | 240.59 | 15.28 | 615 | 126673 | 121124 | 70680032 |
Type I hypersensitivity | 238.83 | 15.28 | 122 | 127166 | 3610 | 70797546 |
Peripheral swelling | 230.67 | 15.28 | 69 | 127219 | 236494 | 70564662 |
Weight increased | 230.34 | 15.28 | 74 | 127214 | 242257 | 70558899 |
Focal nodular hyperplasia | 225.97 | 15.28 | 73 | 127215 | 616 | 70800540 |
Dysarthria | 218.14 | 15.28 | 397 | 126891 | 61916 | 70739240 |
Flushing | 218.04 | 15.28 | 466 | 126822 | 81706 | 70719450 |
Hyperammonaemia | 214.86 | 15.28 | 165 | 127123 | 10128 | 70791028 |
Sinusitis | 214.04 | 15.28 | 26 | 127262 | 169169 | 70631987 |
Non-cirrhotic portal hypertension | 213.21 | 15.28 | 62 | 127226 | 351 | 70800805 |
Decreased appetite | 209.05 | 15.28 | 1089 | 126199 | 303691 | 70497465 |
Febrile neutropenia | 207.45 | 15.28 | 820 | 126468 | 203498 | 70597658 |
Therapy partial responder | 205.29 | 15.28 | 174 | 127114 | 12300 | 70788856 |
Nasopharyngitis | 203.95 | 15.28 | 72 | 127216 | 222134 | 70579022 |
Contraindicated product administered | 199.94 | 15.28 | 10 | 127278 | 134602 | 70666554 |
Hypomagnesaemia | 199.55 | 15.28 | 302 | 126986 | 40462 | 70760694 |
Swelling | 198.91 | 15.28 | 47 | 127241 | 188492 | 70612664 |
Stomatitis | 197.23 | 15.28 | 592 | 126696 | 127919 | 70673237 |
Anaphylactic shock | 194.69 | 15.28 | 265 | 127023 | 32225 | 70768931 |
Hyperammonaemic encephalopathy | 194.61 | 15.28 | 113 | 127175 | 4330 | 70796826 |
Depression | 194.02 | 15.28 | 58 | 127230 | 198916 | 70602240 |
Ascites | 191.94 | 15.28 | 394 | 126894 | 67153 | 70734003 |
Drug interaction | 190.63 | 15.28 | 243 | 127045 | 381198 | 70419958 |
Insomnia | 185.94 | 15.28 | 79 | 127209 | 217727 | 70583429 |
Therapeutic product effect decreased | 183.31 | 15.28 | 21 | 127267 | 142997 | 70658159 |
Abdominal pain | 183.03 | 15.28 | 1144 | 126144 | 340983 | 70460173 |
Product use issue | 181.82 | 15.28 | 49 | 127239 | 179888 | 70621268 |
Splenomegaly | 180.34 | 15.28 | 195 | 127093 | 18675 | 70782481 |
Systemic lupus erythematosus | 167.67 | 15.28 | 3 | 127285 | 101899 | 70699257 |
Dysphonia | 166.29 | 15.28 | 312 | 126976 | 49788 | 70751368 |
Enterocolitis | 165.05 | 15.28 | 157 | 127131 | 12909 | 70788247 |
Proteinuria | 164.63 | 15.28 | 232 | 127056 | 29142 | 70772014 |
Asthma | 164.58 | 15.28 | 14 | 127274 | 120779 | 70680377 |
Overdose | 164.53 | 15.28 | 50 | 127238 | 169695 | 70631461 |
Psoriasis | 161.54 | 15.28 | 3 | 127285 | 98430 | 70702726 |
Contusion | 161.12 | 15.28 | 20 | 127268 | 128016 | 70673140 |
Feeling hot | 160.18 | 15.28 | 302 | 126986 | 48368 | 70752788 |
Abdominal discomfort | 158.97 | 15.28 | 94 | 127194 | 214564 | 70586592 |
Maternal exposure during pregnancy | 158.17 | 15.28 | 13 | 127275 | 115332 | 70685824 |
Anastomotic leak | 157.71 | 15.28 | 62 | 127226 | 967 | 70800189 |
Hyperhidrosis | 157.52 | 15.28 | 557 | 126731 | 131029 | 70670127 |
Pyrexia | 157.06 | 15.28 | 1721 | 125567 | 605231 | 70195925 |
Pain in extremity | 156.73 | 15.28 | 216 | 127072 | 327866 | 70473290 |
Intestinal obstruction | 152.20 | 15.28 | 260 | 127028 | 38565 | 70762591 |
Oxygen saturation decreased | 149.95 | 15.28 | 505 | 126783 | 115924 | 70685232 |
Dyspnoea | 144.94 | 15.28 | 2057 | 125231 | 768003 | 70033153 |
Influenza | 144.94 | 15.28 | 17 | 127271 | 113683 | 70687473 |
Laryngeal discomfort | 141.87 | 15.28 | 49 | 127239 | 518 | 70800638 |
Injection site pain | 141.76 | 15.28 | 21 | 127267 | 117598 | 70683558 |
Nodular regenerative hyperplasia | 140.75 | 15.28 | 61 | 127227 | 1232 | 70799924 |
Hypersensitivity | 139.10 | 15.28 | 794 | 126494 | 229018 | 70572138 |
Cardiac failure congestive | 134.73 | 15.28 | 38 | 127250 | 135419 | 70665737 |
Arthritis | 134.45 | 15.28 | 11 | 127277 | 97969 | 70703187 |
Varices oesophageal | 133.59 | 15.28 | 96 | 127192 | 5321 | 70795835 |
Asthenia | 132.46 | 15.28 | 1328 | 125960 | 456338 | 70344818 |
Cytokine release syndrome | 132.25 | 15.28 | 198 | 127090 | 26269 | 70774887 |
Pneumonia | 132.10 | 15.28 | 586 | 126702 | 595646 | 70205510 |
Hyperthermia | 131.60 | 15.28 | 156 | 127132 | 16515 | 70784641 |
Paraesthesia oral | 131.28 | 15.28 | 150 | 127138 | 15267 | 70785889 |
Pemphigus | 130.63 | 15.28 | 4 | 127284 | 83032 | 70718124 |
Dehydration | 130.15 | 15.28 | 771 | 126517 | 225371 | 70575785 |
Dysaesthesia | 129.80 | 15.28 | 94 | 127194 | 5274 | 70795882 |
Musculoskeletal stiffness | 128.63 | 15.28 | 52 | 127236 | 147708 | 70653448 |
Intentional product misuse | 128.33 | 15.28 | 3 | 127285 | 79592 | 70721564 |
Bronchitis | 128.10 | 15.28 | 27 | 127261 | 117216 | 70683940 |
Anxiety | 126.74 | 15.28 | 125 | 127163 | 220205 | 70580951 |
Carcinoembryonic antigen increased | 125.96 | 15.28 | 65 | 127223 | 1965 | 70799191 |
Colon cancer metastatic | 125.33 | 15.28 | 66 | 127222 | 2082 | 70799074 |
Tumour perforation | 125.03 | 15.28 | 40 | 127248 | 326 | 70800830 |
Suicide attempt | 124.47 | 15.28 | 4 | 127284 | 79506 | 70721650 |
Somnolence | 124.39 | 15.28 | 122 | 127166 | 215484 | 70585672 |
Metastases to peritoneum | 123.46 | 15.28 | 80 | 127208 | 3739 | 70797417 |
Large intestine perforation | 121.98 | 15.28 | 134 | 127154 | 13061 | 70788095 |
Skin reaction | 121.85 | 15.28 | 138 | 127150 | 13911 | 70787245 |
Glossodynia | 120.67 | 15.28 | 9 | 127279 | 86478 | 70714678 |
Immune thrombocytopenia | 119.46 | 15.28 | 147 | 127141 | 16177 | 70784979 |
Osteoarthritis | 118.75 | 15.28 | 3 | 127285 | 74144 | 70727012 |
Drug intolerance | 117.64 | 15.28 | 139 | 127149 | 225548 | 70575608 |
Lower respiratory tract infection | 115.83 | 15.28 | 29 | 127259 | 111884 | 70689272 |
Hospitalisation | 114.04 | 15.28 | 9 | 127279 | 82559 | 70718597 |
Intravascular haemolysis | 112.53 | 15.28 | 44 | 127244 | 676 | 70800480 |
Condition aggravated | 111.30 | 15.28 | 394 | 126894 | 427241 | 70373915 |
Posterior reversible encephalopathy syndrome | 111.29 | 15.28 | 175 | 127113 | 24227 | 70776929 |
Myalgia | 110.19 | 15.28 | 84 | 127204 | 167808 | 70633348 |
Wound | 109.38 | 15.28 | 22 | 127266 | 98710 | 70702446 |
Laryngeal oedema | 108.12 | 15.28 | 97 | 127191 | 7398 | 70793758 |
Ileus | 108.03 | 15.28 | 172 | 127116 | 24065 | 70777091 |
Extravasation | 106.97 | 15.28 | 70 | 127218 | 3327 | 70797829 |
Stress | 104.36 | 15.28 | 4 | 127284 | 67962 | 70733194 |
Adenocarcinoma of colon | 100.80 | 15.28 | 81 | 127207 | 5311 | 70795845 |
Exposure during pregnancy | 100.46 | 15.28 | 18 | 127270 | 87699 | 70713457 |
Disseminated intravascular coagulation | 100.19 | 15.28 | 200 | 127088 | 33398 | 70767758 |
Peritonitis | 99.65 | 15.28 | 173 | 127115 | 25986 | 70775170 |
Intestinal perforation | 99.36 | 15.28 | 133 | 127155 | 15911 | 70785245 |
Hepatic enzyme increased | 98.68 | 15.28 | 82 | 127206 | 156908 | 70644248 |
Administration site extravasation | 98.67 | 15.28 | 46 | 127242 | 1109 | 70800047 |
Blood cholesterol increased | 98.52 | 15.28 | 4 | 127284 | 64600 | 70736556 |
Hypertransaminasaemia | 97.20 | 15.28 | 99 | 127189 | 8844 | 70792312 |
Acute coronary syndrome | 95.76 | 15.28 | 147 | 127141 | 19932 | 70781224 |
Injection site erythema | 95.21 | 15.28 | 10 | 127278 | 72914 | 70728242 |
Hypertensive crisis | 94.66 | 15.28 | 143 | 127145 | 19119 | 70782037 |
Colon cancer | 93.85 | 15.28 | 122 | 127166 | 14184 | 70786972 |
Confusional state | 92.64 | 15.28 | 236 | 127052 | 284162 | 70516994 |
Tumour necrosis | 91.08 | 15.28 | 50 | 127238 | 1717 | 70799439 |
Cholinergic syndrome | 90.60 | 15.28 | 40 | 127248 | 846 | 70800310 |
Portal shunt | 90.26 | 15.28 | 22 | 127266 | 53 | 70801103 |
Haemolytic anaemia | 88.74 | 15.28 | 129 | 127159 | 16665 | 70784491 |
Suicidal ideation | 87.22 | 15.28 | 11 | 127277 | 69585 | 70731571 |
Inappropriate schedule of product administration | 87.05 | 15.28 | 42 | 127246 | 107513 | 70693643 |
Dihydropyrimidine dehydrogenase deficiency | 86.72 | 15.28 | 24 | 127264 | 110 | 70801046 |
Memory impairment | 86.69 | 15.28 | 29 | 127259 | 92612 | 70708544 |
Pneumatosis intestinalis | 86.53 | 15.28 | 77 | 127211 | 5810 | 70795346 |
General physical health deterioration | 85.89 | 15.28 | 720 | 126568 | 235311 | 70565845 |
Mucosal toxicity | 84.68 | 15.28 | 34 | 127254 | 562 | 70800594 |
Rhabdomyolysis | 84.47 | 15.28 | 33 | 127255 | 95727 | 70705429 |
Mobility decreased | 83.70 | 15.28 | 40 | 127248 | 102959 | 70698197 |
Hypokalaemia | 83.07 | 15.28 | 459 | 126829 | 130729 | 70670427 |
Toxic leukoencephalopathy | 82.87 | 15.28 | 39 | 127249 | 961 | 70800195 |
Incorrect dose administered | 82.52 | 15.28 | 11 | 127277 | 66708 | 70734448 |
Platelet count decreased | 80.61 | 15.28 | 572 | 126716 | 177650 | 70623506 |
Tongue oedema | 80.56 | 15.28 | 76 | 127212 | 6183 | 70794973 |
Electrocardiogram QT prolonged | 80.17 | 15.28 | 25 | 127263 | 83492 | 70717664 |
Tumour lysis syndrome | 79.72 | 15.28 | 140 | 127148 | 21220 | 70779936 |
Fluid retention | 79.48 | 15.28 | 10 | 127278 | 63375 | 70737781 |
Stomal varices | 79.09 | 15.28 | 19 | 127269 | 42 | 70801114 |
Diffuse large B-cell lymphoma recurrent | 77.58 | 15.28 | 58 | 127230 | 3418 | 70797738 |
Helicobacter infection | 77.04 | 15.28 | 6 | 127282 | 55650 | 70745506 |
Off label use | 76.47 | 15.28 | 1807 | 125481 | 741253 | 70059903 |
Drug hypersensitivity | 76.37 | 15.28 | 230 | 127058 | 262229 | 70538927 |
Anaphylactic reaction | 76.02 | 15.28 | 301 | 126987 | 74673 | 70726483 |
Treatment failure | 75.91 | 15.28 | 88 | 127200 | 144054 | 70657102 |
Anastomotic complication | 75.60 | 15.28 | 29 | 127259 | 422 | 70800734 |
Pericarditis | 75.03 | 15.28 | 29 | 127259 | 84676 | 70716480 |
Osteoporosis | 74.67 | 15.28 | 3 | 127285 | 48904 | 70752252 |
Migraine | 74.20 | 15.28 | 19 | 127269 | 72219 | 70728937 |
Aggression | 73.87 | 15.28 | 3 | 127285 | 48443 | 70752713 |
Rectal perforation | 73.80 | 15.28 | 34 | 127254 | 797 | 70800359 |
Chronic obstructive pulmonary disease | 73.18 | 15.28 | 24 | 127264 | 77617 | 70723539 |
Blood pressure fluctuation | 72.34 | 15.28 | 10 | 127278 | 59002 | 70742154 |
Upper respiratory tract infection | 72.13 | 15.28 | 26 | 127262 | 79248 | 70721908 |
Pulmonary embolism | 70.91 | 15.28 | 501 | 126787 | 155366 | 70645790 |
Stress cardiomyopathy | 70.86 | 15.28 | 88 | 127200 | 9774 | 70791382 |
Leukoencephalopathy | 70.78 | 15.28 | 76 | 127212 | 7218 | 70793938 |
Cholangitis | 70.39 | 15.28 | 95 | 127193 | 11454 | 70789702 |
Injection site reaction | 70.07 | 15.28 | 5 | 127283 | 49847 | 70751309 |
Electrocardiogram ST segment elevation | 69.90 | 15.28 | 77 | 127211 | 7527 | 70793629 |
Anastomotic fistula | 69.72 | 15.28 | 20 | 127268 | 107 | 70801049 |
Feeling abnormal | 68.56 | 15.28 | 93 | 127195 | 142226 | 70658930 |
Myocardial infarction | 67.75 | 15.28 | 128 | 127160 | 171517 | 70629639 |
Blister | 67.61 | 15.28 | 49 | 127239 | 100477 | 70700679 |
Nicotinic acid deficiency | 67.22 | 15.28 | 21 | 127267 | 157 | 70800999 |
Anaemia | 67.03 | 15.28 | 1056 | 126232 | 402367 | 70398789 |
Cyanosis | 66.63 | 15.28 | 136 | 127152 | 23070 | 70778086 |
Vascular pain | 66.49 | 15.28 | 32 | 127256 | 830 | 70800326 |
Rash pustular | 66.21 | 15.28 | 87 | 127201 | 10221 | 70790935 |
Metastases to lymph nodes | 65.68 | 15.28 | 82 | 127206 | 9156 | 70792000 |
Coronary artery disease | 65.40 | 15.28 | 16 | 127272 | 62720 | 70738436 |
Hiccups | 65.40 | 15.28 | 81 | 127207 | 8971 | 70792185 |
Rectal cancer | 65.10 | 15.28 | 51 | 127237 | 3223 | 70797933 |
Rectal cancer metastatic | 64.25 | 15.28 | 27 | 127261 | 504 | 70800652 |
Neuromyotonia | 63.27 | 15.28 | 18 | 127270 | 93 | 70801063 |
Blood glucose increased | 63.22 | 15.28 | 55 | 127233 | 102927 | 70698229 |
Hallucination | 62.90 | 15.28 | 29 | 127259 | 76231 | 70724925 |
Evans syndrome | 62.50 | 15.28 | 25 | 127263 | 409 | 70800747 |
Sedation | 62.06 | 15.28 | 6 | 127282 | 46725 | 70754431 |
Drug reaction with eosinophilia and systemic symptoms | 62.05 | 15.28 | 14 | 127274 | 57999 | 70743157 |
Hypoalbuminaemia | 60.85 | 15.28 | 117 | 127171 | 19005 | 70782151 |
Subileus | 60.73 | 15.28 | 60 | 127228 | 5167 | 70795989 |
Gastric perforation | 60.29 | 15.28 | 52 | 127236 | 3763 | 70797393 |
Choking sensation | 60.17 | 15.28 | 51 | 127237 | 3604 | 70797552 |
Metastasis | 59.85 | 15.28 | 64 | 127224 | 6050 | 70795106 |
Infusion related reaction | 59.76 | 15.28 | 579 | 126709 | 196955 | 70604201 |
Band sensation | 59.72 | 15.28 | 28 | 127260 | 684 | 70800472 |
Duodenal ulcer perforation | 59.59 | 15.28 | 10 | 127278 | 51102 | 70750054 |
Herpes zoster | 59.36 | 15.28 | 40 | 127248 | 85195 | 70715961 |
Cellulitis | 59.33 | 15.28 | 54 | 127234 | 98874 | 70702282 |
Dizziness | 59.25 | 15.28 | 540 | 126748 | 463601 | 70337555 |
Periportal sinus dilatation | 58.89 | 15.28 | 14 | 127274 | 29 | 70801127 |
Influenza like illness | 58.47 | 15.28 | 22 | 127266 | 65309 | 70735847 |
Tachycardia | 58.35 | 15.28 | 485 | 126803 | 158061 | 70643095 |
Stoma site haemorrhage | 58.21 | 15.28 | 37 | 127251 | 1672 | 70799484 |
Injection site pruritus | 57.92 | 15.28 | 3 | 127285 | 39207 | 70761949 |
Septic shock | 57.73 | 15.28 | 372 | 126916 | 111886 | 70689270 |
Gastrointestinal anastomotic leak | 57.21 | 15.28 | 24 | 127264 | 446 | 70800710 |
Discomfort | 56.99 | 15.28 | 63 | 127225 | 105373 | 70695783 |
Sleep disorder | 56.97 | 15.28 | 27 | 127261 | 69845 | 70731311 |
Speech disorder | 56.97 | 15.28 | 210 | 127078 | 50370 | 70750786 |
Treatment noncompliance | 56.83 | 15.28 | 8 | 127280 | 46566 | 70754590 |
Chemical peritonitis | 56.82 | 15.28 | 21 | 127267 | 274 | 70800882 |
Diffuse large B-cell lymphoma refractory | 56.79 | 15.28 | 33 | 127255 | 1266 | 70799890 |
Large intestinal obstruction | 56.66 | 15.28 | 45 | 127243 | 2901 | 70798255 |
Palmar erythema | 56.40 | 15.28 | 37 | 127251 | 1766 | 70799390 |
COVID-19 | 56.28 | 15.28 | 64 | 127224 | 105693 | 70695463 |
Gait disturbance | 56.16 | 15.28 | 159 | 127129 | 184947 | 70616209 |
ECG signs of myocardial ischaemia | 56.14 | 15.28 | 22 | 127266 | 340 | 70800816 |
Hepatic atrophy | 55.75 | 15.28 | 23 | 127265 | 409 | 70800747 |
Nasal congestion | 55.70 | 15.28 | 24 | 127264 | 65648 | 70735508 |
Cough | 55.51 | 15.28 | 349 | 126939 | 325028 | 70476128 |
Encapsulating peritoneal sclerosis | 55.42 | 15.28 | 28 | 127260 | 809 | 70800347 |
Wrong technique in product usage process | 55.32 | 15.28 | 27 | 127261 | 68671 | 70732485 |
Ocular toxicity | 55.29 | 15.28 | 28 | 127260 | 813 | 70800343 |
Hyperbilirubinaemia | 55.28 | 15.28 | 124 | 127164 | 22444 | 70778712 |
Drug dependence | 54.68 | 15.28 | 3 | 127285 | 37318 | 70763838 |
Oesophageal varices haemorrhage | 54.42 | 15.28 | 49 | 127239 | 3754 | 70797402 |
Necrotising fasciitis | 54.37 | 15.28 | 58 | 127230 | 5468 | 70795688 |
International normalised ratio increased | 53.44 | 15.28 | 40 | 127248 | 80686 | 70720470 |
Drug level increased | 53.22 | 15.28 | 3 | 127285 | 36466 | 70764690 |
Hepatic failure | 52.60 | 15.28 | 224 | 127064 | 57401 | 70743755 |
Psychotic disorder | 52.36 | 15.28 | 4 | 127284 | 37697 | 70763459 |
Recall phenomenon | 51.93 | 15.28 | 29 | 127259 | 1030 | 70800126 |
Emotional distress | 51.50 | 15.28 | 4 | 127284 | 37184 | 70763972 |
Dysphagia | 51.48 | 15.28 | 363 | 126925 | 112471 | 70688685 |
Enterocutaneous fistula | 51.06 | 15.28 | 34 | 127254 | 1664 | 70799492 |
Hypervolaemia | 50.43 | 15.28 | 6 | 127282 | 39700 | 70761456 |
Hypertension | 50.29 | 15.28 | 778 | 126510 | 295255 | 70505901 |
Prinzmetal angina | 50.23 | 15.28 | 33 | 127255 | 1579 | 70799577 |
Splenorenal shunt | 50.02 | 15.28 | 11 | 127277 | 13 | 70801143 |
Urinary tract infection | 49.91 | 15.28 | 253 | 127035 | 248516 | 70552640 |
Diabetes mellitus | 49.62 | 15.28 | 34 | 127254 | 71790 | 70729366 |
Metastases to spleen | 49.58 | 15.28 | 23 | 127265 | 548 | 70800608 |
Colorectal cancer | 49.09 | 15.28 | 68 | 127220 | 8402 | 70792754 |
Anaphylactoid reaction | 48.29 | 15.28 | 52 | 127236 | 4955 | 70796201 |
Breast cancer | 48.22 | 15.28 | 3 | 127285 | 33546 | 70767610 |
Productive cough | 47.88 | 15.28 | 42 | 127246 | 78295 | 70722861 |
Biliary tract infection | 47.79 | 15.28 | 29 | 127259 | 1206 | 70799950 |
Ileal perforation | 47.17 | 15.28 | 26 | 127262 | 900 | 70800256 |
Acute abdomen | 46.86 | 15.28 | 40 | 127248 | 2854 | 70798302 |
Transdifferentiation of neoplasm | 46.63 | 15.28 | 14 | 127274 | 90 | 70801066 |
Medication error | 46.38 | 15.28 | 22 | 127266 | 56890 | 70744266 |
Hypercreatinaemia | 46.18 | 15.28 | 18 | 127270 | 274 | 70800882 |
Cataract | 46.14 | 15.28 | 21 | 127267 | 55624 | 70745532 |
Enterovesical fistula | 45.99 | 15.28 | 27 | 127261 | 1056 | 70800100 |
Viral infection | 45.91 | 15.28 | 7 | 127281 | 38384 | 70762772 |
Malignant ascites | 45.58 | 15.28 | 27 | 127261 | 1074 | 70800082 |
Portal venous gas | 45.29 | 15.28 | 19 | 127269 | 353 | 70800803 |
Hyperpyrexia | 45.27 | 15.28 | 52 | 127236 | 5322 | 70795834 |
Metastases to bone marrow | 44.97 | 15.28 | 23 | 127265 | 682 | 70800474 |
Liver function test abnormal | 44.90 | 15.28 | 27 | 127261 | 61119 | 70740037 |
Infusion related hypersensitivity reaction | 44.85 | 15.28 | 17 | 127271 | 239 | 70800917 |
Steatohepatitis | 44.50 | 15.28 | 24 | 127264 | 795 | 70800361 |
Formication | 44.27 | 15.28 | 48 | 127240 | 4609 | 70796547 |
White blood cell count decreased | 43.97 | 15.28 | 483 | 126805 | 169658 | 70631498 |
Head injury | 43.75 | 15.28 | 5 | 127283 | 34136 | 70767020 |
Skin fissures | 43.53 | 15.28 | 75 | 127213 | 11195 | 70789961 |
Small intestinal perforation | 43.51 | 15.28 | 39 | 127249 | 2970 | 70798186 |
Haemoglobinuria | 43.43 | 15.28 | 23 | 127265 | 734 | 70800422 |
Cold sweat | 43.37 | 15.28 | 95 | 127193 | 16921 | 70784235 |
Pulmonary toxicity | 43.21 | 15.28 | 73 | 127215 | 10725 | 70790431 |
Type II hypersensitivity | 42.90 | 15.28 | 11 | 127277 | 35 | 70801121 |
Oxygen saturation normal | 42.60 | 15.28 | 8 | 127280 | 0 | 70801156 |
Hyperkalaemia | 42.48 | 15.28 | 79 | 127209 | 106512 | 70694644 |
Wound dehiscence | 42.38 | 15.28 | 54 | 127234 | 6154 | 70795002 |
Metastases to meninges | 42.13 | 15.28 | 39 | 127249 | 3097 | 70798059 |
Heart rate decreased | 41.99 | 15.28 | 30 | 127258 | 61985 | 70739171 |
Performance status decreased | 41.89 | 15.28 | 51 | 127237 | 5550 | 70795606 |
Oropharyngeal discomfort | 41.69 | 15.28 | 53 | 127235 | 6026 | 70795130 |
Type 2 diabetes mellitus | 40.88 | 15.28 | 14 | 127274 | 44066 | 70757090 |
Colitis | 40.85 | 15.28 | 224 | 127064 | 63590 | 70737566 |
Laryngeal dyspnoea | 40.56 | 15.28 | 16 | 127272 | 252 | 70800904 |
Oropharyngeal pain | 40.52 | 15.28 | 69 | 127219 | 96241 | 70704915 |
Amaurosis fugax | 40.51 | 15.28 | 23 | 127265 | 844 | 70800312 |
Peripheral motor neuropathy | 40.25 | 15.28 | 38 | 127250 | 3094 | 70798062 |
Cardiac disorder | 39.89 | 15.28 | 29 | 127259 | 59386 | 70741770 |
Hypoglycaemia | 39.34 | 15.28 | 68 | 127220 | 94296 | 70706860 |
Neck pain | 39.23 | 15.28 | 37 | 127251 | 66620 | 70734536 |
Trismus | 39.12 | 15.28 | 47 | 127241 | 5044 | 70796112 |
Temperature intolerance | 39.00 | 15.28 | 62 | 127226 | 8661 | 70792495 |
Rhinorrhoea | 38.88 | 15.28 | 37 | 127251 | 66334 | 70734822 |
Nervousness | 38.79 | 15.28 | 5 | 127283 | 31115 | 70770041 |
Basal cell carcinoma | 38.39 | 15.28 | 7 | 127281 | 33691 | 70767465 |
Blood pressure systolic increased | 38.37 | 15.28 | 28 | 127260 | 57231 | 70743925 |
Unevaluable event | 38.21 | 15.28 | 23 | 127265 | 52040 | 70749116 |
Acute respiratory distress syndrome | 38.14 | 15.28 | 161 | 127127 | 41093 | 70760063 |
Road traffic accident | 37.84 | 15.28 | 8 | 127280 | 34674 | 70766482 |
Hypovolaemic shock | 37.84 | 15.28 | 69 | 127219 | 10768 | 70790388 |
Loss of personal independence in daily activities | 37.43 | 15.28 | 59 | 127229 | 84851 | 70716305 |
Hepatocellular injury | 37.40 | 15.28 | 173 | 127115 | 45918 | 70755238 |
Small intestinal obstruction | 37.22 | 15.28 | 113 | 127175 | 24542 | 70776614 |
Portal vein thrombosis | 37.17 | 15.28 | 47 | 127241 | 5315 | 70795841 |
Aortitis | 37.09 | 15.28 | 26 | 127262 | 1385 | 70799771 |
Cold dysaesthesia | 37.07 | 15.28 | 8 | 127280 | 8 | 70801148 |
K-ras gene mutation | 37.03 | 15.28 | 10 | 127278 | 41 | 70801115 |
Neutropenic sepsis | 36.73 | 15.28 | 113 | 127175 | 24717 | 70776439 |
Colitis ulcerative | 36.65 | 15.28 | 8 | 127280 | 33915 | 70767241 |
Balance disorder | 36.62 | 15.28 | 66 | 127222 | 90062 | 70711094 |
Hypertrichosis | 36.50 | 15.28 | 24 | 127264 | 1150 | 70800006 |
Hydronephrosis | 36.50 | 15.28 | 83 | 127205 | 15159 | 70785997 |
Portal vein dilatation | 36.28 | 15.28 | 10 | 127278 | 45 | 70801111 |
Haematoma | 36.09 | 15.28 | 21 | 127267 | 48397 | 70752759 |
Factor VII deficiency | 36.01 | 15.28 | 9 | 127279 | 25 | 70801131 |
Underdose | 35.96 | 15.28 | 5 | 127283 | 29378 | 70771778 |
Abnormal behaviour | 35.89 | 15.28 | 9 | 127279 | 34700 | 70766456 |
Hallucination, visual | 35.89 | 15.28 | 5 | 127283 | 29332 | 70771824 |
Irritability | 35.69 | 15.28 | 12 | 127276 | 38213 | 70762943 |
Lip oedema | 35.67 | 15.28 | 47 | 127241 | 5536 | 70795620 |
Gastrooesophageal reflux disease | 35.60 | 15.28 | 68 | 127220 | 90771 | 70710385 |
Splenic artery thrombosis | 34.94 | 15.28 | 10 | 127278 | 53 | 70801103 |
Jaundice | 34.88 | 15.28 | 180 | 127108 | 49928 | 70751228 |
Perforation | 34.87 | 15.28 | 24 | 127264 | 1241 | 70799915 |
Embolism | 34.81 | 15.28 | 74 | 127214 | 12914 | 70788242 |
Full blood count abnormal | 34.62 | 15.28 | 9 | 127279 | 33869 | 70767287 |
Pharyngeal paraesthesia | 34.41 | 15.28 | 30 | 127258 | 2202 | 70798954 |
Neutropenic colitis | 34.15 | 15.28 | 44 | 127244 | 5070 | 70796086 |
Obesity | 34.11 | 15.28 | 4 | 127284 | 26767 | 70774389 |
Blood pressure immeasurable | 33.71 | 15.28 | 28 | 127260 | 1924 | 70799232 |
Abortion spontaneous | 33.63 | 15.28 | 4 | 127284 | 26475 | 70774681 |
Hypotension | 33.40 | 15.28 | 956 | 126332 | 403425 | 70397731 |
Product prescribing error | 33.40 | 15.28 | 14 | 127274 | 38938 | 70762218 |
Sensation of foreign body | 33.14 | 15.28 | 42 | 127246 | 4760 | 70796396 |
Peripheral sensorimotor neuropathy | 33.04 | 15.28 | 32 | 127256 | 2690 | 70798466 |
Guillain-Barre syndrome | 33.03 | 15.28 | 55 | 127233 | 7985 | 70793171 |
Accidental overdose | 32.84 | 15.28 | 11 | 127277 | 35110 | 70766046 |
Toxic epidermal necrolysis | 32.68 | 15.28 | 15 | 127273 | 39542 | 70761614 |
Muscle contractions involuntary | 32.66 | 15.28 | 35 | 127253 | 3316 | 70797840 |
Aortic thrombosis | 32.49 | 15.28 | 25 | 127263 | 1538 | 70799618 |
Respiratory distress | 32.44 | 15.28 | 188 | 127100 | 54462 | 70746694 |
Oedema peripheral | 32.34 | 15.28 | 258 | 127030 | 227833 | 70573323 |
Metastases to ovary | 32.29 | 15.28 | 14 | 127274 | 283 | 70800873 |
Granulocyte count decreased | 32.12 | 15.28 | 24 | 127264 | 1413 | 70799743 |
Right ventricular ejection fraction decreased | 32.05 | 15.28 | 9 | 127279 | 44 | 70801112 |
Noninfective epididymitis | 31.95 | 15.28 | 6 | 127282 | 0 | 70801156 |
Biliary fistula | 31.75 | 15.28 | 10 | 127278 | 77 | 70801079 |
Intentional product use issue | 31.62 | 15.28 | 110 | 127178 | 120032 | 70681124 |
Haemolytic uraemic syndrome | 31.53 | 15.28 | 38 | 127250 | 4092 | 70797064 |
Trichomegaly | 31.42 | 15.28 | 10 | 127278 | 80 | 70801076 |
Cystitis radiation | 31.29 | 15.28 | 11 | 127277 | 123 | 70801033 |
Oesophageal haemorrhage | 31.23 | 15.28 | 25 | 127263 | 1630 | 70799526 |
Haemolysis | 31.17 | 15.28 | 66 | 127222 | 11485 | 70789671 |
Dysgeusia | 31.17 | 15.28 | 173 | 127115 | 49329 | 70751827 |
Liver abscess | 31.03 | 15.28 | 44 | 127244 | 5555 | 70795601 |
Short-bowel syndrome | 31.02 | 15.28 | 16 | 127272 | 483 | 70800673 |
Femur fracture | 30.96 | 15.28 | 13 | 127275 | 36119 | 70765037 |
Retching | 30.76 | 15.28 | 80 | 127208 | 15899 | 70785257 |
Eosinophilia | 30.75 | 15.28 | 17 | 127271 | 40302 | 70760854 |
Pancreatic carcinoma metastatic | 30.41 | 15.28 | 36 | 127252 | 3804 | 70797352 |
Intestinal ischaemia | 30.35 | 15.28 | 67 | 127221 | 11997 | 70789159 |
Pulmonary artery thrombosis | 30.27 | 15.28 | 22 | 127266 | 1241 | 70799915 |
Thrombotic microangiopathy | 30.00 | 15.28 | 85 | 127203 | 17763 | 70783393 |
Hepatic function abnormal | 29.98 | 15.28 | 217 | 127071 | 67779 | 70733377 |
Cytomegalovirus infection | 29.98 | 15.28 | 17 | 127271 | 39741 | 70761415 |
Adverse drug reaction | 29.79 | 15.28 | 31 | 127257 | 53313 | 70747843 |
Suffocation feeling | 29.78 | 15.28 | 24 | 127264 | 1580 | 70799576 |
Haematemesis | 29.71 | 15.28 | 169 | 127119 | 48628 | 70752528 |
Thrombocytopenic purpura | 29.70 | 15.28 | 28 | 127260 | 2276 | 70798880 |
Adverse event | 29.64 | 15.28 | 27 | 127261 | 49434 | 70751722 |
Cytopenia | 29.61 | 15.28 | 83 | 127205 | 17240 | 70783916 |
Hypophagia | 29.40 | 15.28 | 150 | 127138 | 41420 | 70759736 |
Perforation bile duct | 29.39 | 15.28 | 8 | 127280 | 34 | 70801122 |
Nephrolithiasis | 29.37 | 15.28 | 25 | 127263 | 47298 | 70753858 |
Appendicitis noninfective | 29.29 | 15.28 | 7 | 127281 | 15 | 70801141 |
Osteomyelitis | 29.22 | 15.28 | 9 | 127279 | 30309 | 70770847 |
Hypersplenism | 29.11 | 15.28 | 15 | 127273 | 452 | 70800704 |
Ear pain | 28.84 | 15.28 | 7 | 127281 | 27592 | 70773564 |
Alopecia | 28.84 | 15.28 | 223 | 127065 | 198267 | 70602889 |
Toxicity to various agents | 28.60 | 15.28 | 498 | 126790 | 381674 | 70419482 |
Failure to anastomose | 28.55 | 15.28 | 12 | 127276 | 224 | 70800932 |
Adenocarcinoma | 28.52 | 15.28 | 34 | 127254 | 3619 | 70797537 |
Fatigue | 28.52 | 15.28 | 1200 | 126088 | 823119 | 69978037 |
Pelvic abscess | 28.41 | 15.28 | 25 | 127263 | 1858 | 70799298 |
Heart rate irregular | 28.36 | 15.28 | 9 | 127279 | 29734 | 70771422 |
Localised infection | 28.30 | 15.28 | 12 | 127276 | 33146 | 70768010 |
Hyperaemia | 28.18 | 15.28 | 30 | 127258 | 2821 | 70798335 |
Autoimmune haemolytic anaemia | 27.91 | 15.28 | 50 | 127238 | 7696 | 70793460 |
Oral dysaesthesia | 27.90 | 15.28 | 11 | 127277 | 173 | 70800983 |
Congestive cardiomyopathy | 27.85 | 15.28 | 61 | 127227 | 10865 | 70790291 |
Medical device site extravasation | 27.80 | 15.28 | 6 | 127282 | 6 | 70801150 |
Pelvic fluid collection | 27.76 | 15.28 | 17 | 127271 | 719 | 70800437 |
Carbohydrate antigen 19-9 increased | 27.75 | 15.28 | 14 | 127274 | 403 | 70800753 |
Sciatic nerve palsy | 27.75 | 15.28 | 9 | 127279 | 77 | 70801079 |
Blood glucose decreased | 27.56 | 15.28 | 5 | 127283 | 24154 | 70777002 |
Hepatectomy | 27.55 | 15.28 | 11 | 127277 | 179 | 70800977 |
Hypothyroidism | 27.39 | 15.28 | 25 | 127263 | 45730 | 70755426 |
Device issue | 27.35 | 15.28 | 5 | 127283 | 24020 | 70777136 |
Tumour ulceration | 27.28 | 15.28 | 11 | 127277 | 184 | 70800972 |
Multiple sclerosis | 27.24 | 15.28 | 6 | 127282 | 25279 | 70775877 |
Tooth disorder | 27.21 | 15.28 | 5 | 127283 | 23933 | 70777223 |
Musculoskeletal pain | 27.07 | 15.28 | 78 | 127210 | 90249 | 70710907 |
Gastric varices haemorrhage | 26.98 | 15.28 | 13 | 127275 | 338 | 70800818 |
Koebner phenomenon | 26.98 | 15.28 | 8 | 127280 | 49 | 70801107 |
Perineal disorder | 26.90 | 15.28 | 7 | 127281 | 24 | 70801132 |
Blood creatine phosphokinase increased | 26.59 | 15.28 | 43 | 127245 | 61220 | 70739936 |
Tendonitis | 26.53 | 15.28 | 4 | 127284 | 22118 | 70779038 |
Hyperfibrinolysis | 26.47 | 15.28 | 7 | 127281 | 26 | 70801130 |
Hypoacusis | 26.46 | 15.28 | 8 | 127280 | 27261 | 70773895 |
Impaired healing | 26.33 | 15.28 | 59 | 127229 | 74315 | 70726841 |
Oesophagitis | 26.30 | 15.28 | 95 | 127193 | 22557 | 70778599 |
Device related infection | 26.26 | 15.28 | 121 | 127167 | 32064 | 70769092 |
Hypoaesthesia oral | 26.21 | 15.28 | 64 | 127224 | 12236 | 70788920 |
Skin laceration | 26.20 | 15.28 | 7 | 127281 | 25871 | 70775285 |
Endothelial dysfunction | 26.09 | 15.28 | 11 | 127277 | 207 | 70800949 |
Blood pressure diastolic decreased | 26.05 | 15.28 | 7 | 127281 | 25773 | 70775383 |
Poor quality sleep | 26.03 | 15.28 | 3 | 127285 | 20346 | 70780810 |
Chest discomfort | 25.93 | 15.28 | 339 | 126949 | 124042 | 70677114 |
Death | 25.92 | 15.28 | 707 | 126581 | 509354 | 70291802 |
Hepatic encephalopathy | 25.89 | 15.28 | 93 | 127195 | 22025 | 70779131 |
Pharyngeal dyskinesia | 25.82 | 15.28 | 8 | 127280 | 58 | 70801098 |
Necrotising oesophagitis | 25.70 | 15.28 | 16 | 127272 | 697 | 70800459 |
Fistula of small intestine | 25.70 | 15.28 | 16 | 127272 | 697 | 70800459 |
Gait inability | 25.69 | 15.28 | 28 | 127260 | 47147 | 70754009 |
Dry eye | 25.52 | 15.28 | 13 | 127275 | 32269 | 70768887 |
Cholestasis | 25.43 | 15.28 | 160 | 127128 | 47712 | 70753444 |
Mucosal disorder | 25.36 | 15.28 | 30 | 127258 | 3168 | 70797988 |
Premature delivery | 25.21 | 15.28 | 4 | 127284 | 21300 | 70779856 |
Gastrointestinal necrosis | 25.15 | 15.28 | 38 | 127250 | 5080 | 70796076 |
Full blood count decreased | 25.12 | 15.28 | 6 | 127282 | 23912 | 70777244 |
Pulmonary hypertension | 24.93 | 15.28 | 28 | 127260 | 46508 | 70754648 |
Tonic clonic movements | 24.92 | 15.28 | 24 | 127264 | 2003 | 70799153 |
Night sweats | 24.83 | 15.28 | 25 | 127263 | 43659 | 70757497 |
Sinus bradycardia | 24.67 | 15.28 | 6 | 127282 | 23617 | 70777539 |
Rectal cancer recurrent | 24.63 | 15.28 | 7 | 127281 | 36 | 70801120 |
Haemorrhage intracranial | 24.53 | 15.28 | 7 | 127281 | 24770 | 70776386 |
Pseudocirrhosis | 24.46 | 15.28 | 15 | 127273 | 636 | 70800520 |
Oropharyngeal spasm | 24.43 | 15.28 | 12 | 127276 | 326 | 70800830 |
Drug ineffective for unapproved indication | 24.36 | 15.28 | 20 | 127268 | 38518 | 70762638 |
Abdominal wall oedema | 24.28 | 15.28 | 5 | 127283 | 3 | 70801153 |
Acute polyneuropathy | 24.26 | 15.28 | 13 | 127275 | 425 | 70800731 |
Gene mutation | 24.24 | 15.28 | 25 | 127263 | 2266 | 70798890 |
Limb injury | 24.19 | 15.28 | 8 | 127280 | 25744 | 70775412 |
Diffuse large B-cell lymphoma | 23.99 | 15.28 | 65 | 127223 | 13237 | 70787919 |
Gastrointestinal stoma complication | 23.98 | 15.28 | 25 | 127263 | 2295 | 70798861 |
Pulmonary fibrosis | 23.70 | 15.28 | 123 | 127165 | 34187 | 70766969 |
Loss of consciousness | 23.69 | 15.28 | 402 | 126886 | 155314 | 70645842 |
Post embolisation syndrome | 23.65 | 15.28 | 8 | 127280 | 79 | 70801077 |
Subacute cutaneous lupus erythematosus | 23.61 | 15.28 | 29 | 127259 | 3184 | 70797972 |
Platelet count increased | 23.56 | 15.28 | 4 | 127284 | 20269 | 70780887 |
Intervertebral disc protrusion | 23.38 | 15.28 | 5 | 127283 | 21498 | 70779658 |
Nephrotic syndrome | 23.35 | 15.28 | 56 | 127232 | 10584 | 70790572 |
Atypical haemolytic uraemic syndrome | 23.34 | 15.28 | 16 | 127272 | 822 | 70800334 |
Perihepatic abscess | 23.33 | 15.28 | 9 | 127279 | 133 | 70801023 |
Vasospasm | 23.28 | 15.28 | 17 | 127271 | 966 | 70800190 |
Respiratory arrest | 23.27 | 15.28 | 38 | 127250 | 53895 | 70747261 |
Abdominal abscess | 23.11 | 15.28 | 42 | 127246 | 6536 | 70794620 |
Retroperitoneal abscess | 23.07 | 15.28 | 12 | 127276 | 369 | 70800787 |
Product substitution issue | 23.01 | 15.28 | 3 | 127285 | 18510 | 70782646 |
Mixed adenoneuroendocrine carcinoma | 22.96 | 15.28 | 6 | 127282 | 21 | 70801135 |
Acral peeling skin syndrome | 22.81 | 15.28 | 7 | 127281 | 49 | 70801107 |
Therapy interrupted | 22.79 | 15.28 | 8 | 127280 | 24794 | 70776362 |
Livedo reticularis | 22.78 | 15.28 | 31 | 127257 | 3767 | 70797389 |
Obstruction gastric | 22.76 | 15.28 | 20 | 127268 | 1484 | 70799672 |
Hallucination, auditory | 22.71 | 15.28 | 3 | 127285 | 18325 | 70782831 |
Hepatic lesion | 22.70 | 15.28 | 40 | 127248 | 6077 | 70795079 |
Catheter site extravasation | 22.69 | 15.28 | 12 | 127276 | 382 | 70800774 |
Seizure | 22.66 | 15.28 | 207 | 127081 | 177755 | 70623401 |
Interventricular septum rupture | 22.54 | 15.28 | 6 | 127282 | 23 | 70801133 |
Pain in jaw | 22.50 | 15.28 | 26 | 127262 | 42643 | 70758513 |
Cardiomegaly | 22.41 | 15.28 | 8 | 127280 | 24537 | 70776619 |
Infection | 22.38 | 15.28 | 256 | 127032 | 210529 | 70590627 |
Surgery | 22.36 | 15.28 | 13 | 127275 | 29976 | 70771180 |
Hypersomnia | 22.22 | 15.28 | 5 | 127283 | 20759 | 70780397 |
Adenocarcinoma gastric | 22.19 | 15.28 | 21 | 127267 | 1715 | 70799441 |
Organising pneumonia | 22.17 | 15.28 | 53 | 127235 | 9997 | 70791159 |
Renal hydrocele | 22.14 | 15.28 | 6 | 127282 | 25 | 70801131 |
Hyperlipasaemia | 22.14 | 15.28 | 17 | 127271 | 1043 | 70800113 |
Disease recurrence | 22.08 | 15.28 | 129 | 127159 | 37474 | 70763682 |
Allodynia | 22.04 | 15.28 | 19 | 127269 | 1374 | 70799782 |
Protein urine | 22.00 | 15.28 | 19 | 127269 | 1377 | 70799779 |
Pancreatic neuroendocrine tumour metastatic | 21.97 | 15.28 | 9 | 127279 | 157 | 70800999 |
Epistaxis | 21.93 | 15.28 | 281 | 127007 | 102346 | 70698810 |
Limbic encephalitis | 21.87 | 15.28 | 15 | 127273 | 771 | 70800385 |
Gout | 21.87 | 15.28 | 7 | 127281 | 22999 | 70778157 |
Venoocclusive disease | 21.81 | 15.28 | 32 | 127256 | 4168 | 70796988 |
Labelled drug-drug interaction medication error | 21.79 | 15.28 | 8 | 127280 | 24119 | 70777037 |
Pigmentation disorder | 21.79 | 15.28 | 35 | 127253 | 4931 | 70796225 |
Microangiopathic haemolytic anaemia | 21.77 | 15.28 | 19 | 127269 | 1397 | 70799759 |
Metastases to muscle | 21.76 | 15.28 | 11 | 127277 | 318 | 70800838 |
Rectal adenocarcinoma | 21.72 | 15.28 | 19 | 127269 | 1401 | 70799755 |
Gallbladder disorder | 21.71 | 15.28 | 3 | 127285 | 17709 | 70783447 |
Blood alkaline phosphatase abnormal | 21.63 | 15.28 | 15 | 127273 | 785 | 70800371 |
Blood potassium increased | 21.60 | 15.28 | 11 | 127277 | 27315 | 70773841 |
Eczema impetiginous | 21.59 | 15.28 | 6 | 127282 | 28 | 70801128 |
Astringent therapy | 21.59 | 15.28 | 6 | 127282 | 28 | 70801128 |
Cardiospasm | 21.59 | 15.28 | 6 | 127282 | 28 | 70801128 |
Fingerprint loss | 21.57 | 15.28 | 7 | 127281 | 60 | 70801096 |
Peripheral nerve injury | 21.51 | 15.28 | 14 | 127274 | 659 | 70800497 |
Hepatic vein stenosis | 21.37 | 15.28 | 7 | 127281 | 62 | 70801094 |
Proctitis | 21.27 | 15.28 | 29 | 127259 | 3529 | 70797627 |
Prostatic calcification | 21.27 | 15.28 | 7 | 127281 | 63 | 70801093 |
Tremor | 21.27 | 15.28 | 395 | 126893 | 155229 | 70645927 |
Female genital tract fistula | 21.20 | 15.28 | 27 | 127261 | 3076 | 70798080 |
No adverse event | 21.19 | 15.28 | 16 | 127272 | 32137 | 70769019 |
Cardiac ventricular disorder | 21.15 | 15.28 | 11 | 127277 | 338 | 70800818 |
Ischiorectal hernia | 21.15 | 15.28 | 5 | 127283 | 10 | 70801146 |
Hand-foot-genital syndrome | 21.15 | 15.28 | 5 | 127283 | 10 | 70801146 |
Axonal and demyelinating polyneuropathy | 21.15 | 15.28 | 5 | 127283 | 10 | 70801146 |
Venous thrombosis limb | 21.09 | 15.28 | 31 | 127257 | 4044 | 70797112 |
Skin disorder | 21.09 | 15.28 | 109 | 127179 | 30248 | 70770908 |
Musculoskeletal disorder | 21.00 | 15.28 | 5 | 127283 | 19966 | 70781190 |
Oedema | 20.94 | 15.28 | 105 | 127183 | 103476 | 70697680 |
Sciatica | 20.88 | 15.28 | 9 | 127279 | 24618 | 70776538 |
Hiatus hernia | 20.87 | 15.28 | 6 | 127282 | 21128 | 70780028 |
Liver function test increased | 20.86 | 15.28 | 18 | 127270 | 33829 | 70767327 |
Toothache | 20.63 | 15.28 | 4 | 127284 | 18426 | 70782730 |
Hemiparaesthesia | 20.57 | 15.28 | 8 | 127280 | 121 | 70801035 |
Cachexia | 20.55 | 15.28 | 51 | 127237 | 9849 | 70791307 |
Skin discolouration | 20.50 | 15.28 | 22 | 127266 | 37303 | 70763853 |
Amnesia | 20.47 | 15.28 | 39 | 127249 | 52116 | 70749040 |
Hypocapnia | 20.36 | 15.28 | 13 | 127275 | 592 | 70800564 |
Therapeutic response unexpected | 20.31 | 15.28 | 4 | 127284 | 18227 | 70782929 |
Vocal cord paralysis | 20.31 | 15.28 | 23 | 127265 | 2318 | 70798838 |
Oesophageal fistula | 20.30 | 15.28 | 11 | 127277 | 368 | 70800788 |
Tumour haemorrhage | 20.26 | 15.28 | 29 | 127259 | 3693 | 70797463 |
Hepatic infarction | 20.26 | 15.28 | 15 | 127273 | 871 | 70800285 |
Gastric disorder | 20.20 | 15.28 | 18 | 127270 | 33304 | 70767852 |
Swelling face | 20.08 | 15.28 | 53 | 127235 | 63111 | 70738045 |
Induration | 19.92 | 15.28 | 20 | 127268 | 1756 | 70799400 |
Thrombotic thrombocytopenic purpura | 19.90 | 15.28 | 38 | 127250 | 6139 | 70795017 |
Delirium | 19.84 | 15.28 | 68 | 127220 | 74546 | 70726610 |
Drug eruption | 19.84 | 15.28 | 25 | 127263 | 39471 | 70761685 |
Gastrointestinal mucosal necrosis | 19.81 | 15.28 | 9 | 127279 | 204 | 70800952 |
Diaphragmatic paralysis | 19.75 | 15.28 | 16 | 127272 | 1061 | 70800095 |
Musculoskeletal discomfort | 19.69 | 15.28 | 4 | 127284 | 17828 | 70783328 |
Catheter site bruise | 19.51 | 15.28 | 10 | 127278 | 298 | 70800858 |
Impaired work ability | 19.49 | 15.28 | 3 | 127285 | 16337 | 70784819 |
Dry skin | 19.44 | 15.28 | 169 | 127119 | 55762 | 70745394 |
Tachypnoea | 19.32 | 15.28 | 102 | 127186 | 28536 | 70772620 |
Immunodeficiency | 19.25 | 15.28 | 4 | 127284 | 17551 | 70783605 |
Therapy non-responder | 19.19 | 15.28 | 72 | 127216 | 76843 | 70724313 |
Implant site dehiscence | 19.19 | 15.28 | 6 | 127282 | 45 | 70801111 |
Anger | 19.15 | 15.28 | 3 | 127285 | 16129 | 70785027 |
Peripheral ischaemia | 19.12 | 15.28 | 46 | 127242 | 8712 | 70792444 |
Metastases to diaphragm | 19.07 | 15.28 | 6 | 127282 | 46 | 70801110 |
Macroglossia | 19.07 | 15.28 | 16 | 127272 | 1115 | 70800041 |
Product administration error | 19.06 | 15.28 | 15 | 127273 | 29508 | 70771648 |
Heart rate increased | 19.03 | 15.28 | 112 | 127176 | 106036 | 70695120 |
Anal sphincter atony | 19.00 | 15.28 | 10 | 127278 | 315 | 70800841 |
Oesophagobronchial fistula | 18.93 | 15.28 | 9 | 127279 | 227 | 70800929 |
Monocytopenia | 18.86 | 15.28 | 8 | 127280 | 153 | 70801003 |
Eye pain | 18.84 | 15.28 | 20 | 127268 | 34082 | 70767074 |
Catabolic state | 18.83 | 15.28 | 7 | 127281 | 93 | 70801063 |
Infusion site hypoaesthesia | 18.82 | 15.28 | 5 | 127283 | 19 | 70801137 |
Chemotherapy cardiotoxicity attenuation | 18.82 | 15.28 | 5 | 127283 | 19 | 70801137 |
Lymphangiosis carcinomatosa | 18.78 | 15.28 | 20 | 127268 | 1881 | 70799275 |
Mental impairment | 18.78 | 15.28 | 4 | 127284 | 17251 | 70783905 |
Mucocutaneous rash | 18.64 | 15.28 | 6 | 127282 | 50 | 70801106 |
Restless legs syndrome | 18.63 | 15.28 | 5 | 127283 | 18423 | 70782733 |
Pulmonary congestion | 18.62 | 15.28 | 11 | 127277 | 25143 | 70776013 |
Impaired quality of life | 18.58 | 15.28 | 46 | 127242 | 8870 | 70792286 |
Bradycardia | 18.56 | 15.28 | 139 | 127149 | 124476 | 70676680 |
Extrapyramidal disorder | 18.54 | 15.28 | 7 | 127281 | 20743 | 70780413 |
Intrahepatic portal hepatic venous fistula | 18.53 | 15.28 | 4 | 127284 | 4 | 70801152 |
Neonatal asphyxia | 18.53 | 15.28 | 4 | 127284 | 4 | 70801152 |
Inferior vena cava stenosis | 18.53 | 15.28 | 6 | 127282 | 51 | 70801105 |
Eczema | 18.45 | 15.28 | 20 | 127268 | 33761 | 70767395 |
Pruritus | 18.45 | 15.28 | 777 | 126511 | 344783 | 70456373 |
Hypercholesterolaemia | 18.16 | 15.28 | 5 | 127283 | 18112 | 70783044 |
Inflammation | 18.13 | 15.28 | 76 | 127212 | 78589 | 70722567 |
Pneumoperitoneum | 18.09 | 15.28 | 24 | 127264 | 2845 | 70798311 |
Cholelithiasis | 18.06 | 15.28 | 36 | 127252 | 47304 | 70753852 |
Cognitive disorder | 18.00 | 15.28 | 53 | 127235 | 60903 | 70740253 |
Aplastic anaemia | 17.94 | 15.28 | 4 | 127284 | 16712 | 70784444 |
Bursitis | 17.93 | 15.28 | 13 | 127275 | 26660 | 70774496 |
Osteopenia | 17.91 | 15.28 | 4 | 127284 | 16693 | 70784463 |
Endometrial dysplasia | 17.71 | 15.28 | 5 | 127283 | 25 | 70801131 |
Malaise | 17.70 | 15.28 | 948 | 126340 | 431984 | 70369172 |
Radiation interaction | 17.67 | 15.28 | 6 | 127282 | 60 | 70801096 |
Tetany | 17.63 | 15.28 | 21 | 127267 | 2233 | 70798923 |
Metastases to retroperitoneum | 17.56 | 15.28 | 10 | 127278 | 369 | 70800787 |
Fistula | 17.49 | 15.28 | 51 | 127237 | 10830 | 70790326 |
Pneumonitis | 17.46 | 15.28 | 162 | 127126 | 54435 | 70746721 |
Soft tissue necrosis | 17.45 | 15.28 | 13 | 127275 | 762 | 70800394 |
Mental disorder | 17.42 | 15.28 | 15 | 127273 | 28225 | 70772931 |
Mucosal necrosis | 17.42 | 15.28 | 7 | 127281 | 116 | 70801040 |
Cerebrovascular accident | 17.35 | 15.28 | 169 | 127119 | 143301 | 70657855 |
Splenic abscess | 17.35 | 15.28 | 11 | 127277 | 495 | 70800661 |
Disability | 17.31 | 15.28 | 3 | 127285 | 14980 | 70786176 |
Aortic intramural haematoma | 17.31 | 15.28 | 7 | 127281 | 118 | 70801038 |
Pachymeningitis | 17.26 | 15.28 | 9 | 127279 | 278 | 70800878 |
Therapy cessation | 17.24 | 15.28 | 21 | 127267 | 33655 | 70767501 |
Tumour fistulisation | 17.24 | 15.28 | 5 | 127283 | 28 | 70801128 |
VIth nerve disorder | 17.24 | 15.28 | 5 | 127283 | 28 | 70801128 |
Palpitations | 17.24 | 15.28 | 122 | 127166 | 110631 | 70690525 |
Feeling cold | 17.20 | 15.28 | 91 | 127197 | 25479 | 70775677 |
Renal disorder | 17.14 | 15.28 | 26 | 127262 | 37983 | 70763173 |
Nephritis allergic | 17.09 | 15.28 | 12 | 127276 | 641 | 70800515 |
Gastrointestinal obstruction | 17.03 | 15.28 | 17 | 127271 | 1482 | 70799674 |
Fear | 17.02 | 15.28 | 8 | 127280 | 20803 | 70780353 |
Acute promyelocytic leukaemia | 17.00 | 15.28 | 17 | 127271 | 1485 | 70799671 |
Depressed mood | 16.99 | 15.28 | 33 | 127255 | 43787 | 70757369 |
Blood triglycerides increased | 16.97 | 15.28 | 7 | 127281 | 19657 | 70781499 |
Colon cancer recurrent | 16.94 | 15.28 | 7 | 127281 | 125 | 70801031 |
Motion sickness | 16.85 | 15.28 | 13 | 127275 | 803 | 70800353 |
Aplasia | 16.82 | 15.28 | 39 | 127249 | 7212 | 70793944 |
Laboratory test abnormal | 16.82 | 15.28 | 13 | 127275 | 25810 | 70775346 |
Jaw operation | 16.81 | 15.28 | 13 | 127275 | 806 | 70800350 |
Metastatic neoplasm | 16.74 | 15.28 | 30 | 127258 | 4618 | 70796538 |
Cerebral vasoconstriction | 16.73 | 15.28 | 16 | 127272 | 1324 | 70799832 |
Aortic dissection | 16.73 | 15.28 | 27 | 127261 | 3820 | 70797336 |
Coombs test positive | 16.71 | 15.28 | 8 | 127280 | 205 | 70800951 |
Lacrimation disorder | 16.60 | 15.28 | 4 | 127284 | 9 | 70801147 |
Biliary cancer metastatic | 16.60 | 15.28 | 4 | 127284 | 9 | 70801147 |
Blindness transient | 16.45 | 15.28 | 29 | 127259 | 4407 | 70796749 |
Abdominal sepsis | 16.45 | 15.28 | 19 | 127269 | 1956 | 70799200 |
Ichthyosis | 16.40 | 15.28 | 7 | 127281 | 136 | 70801020 |
Vascular access site occlusion | 16.32 | 15.28 | 6 | 127282 | 77 | 70801079 |
Venous injury | 16.31 | 15.28 | 12 | 127276 | 690 | 70800466 |
Neutrophil count abnormal | 16.29 | 15.28 | 24 | 127264 | 3137 | 70798019 |
Chronic myeloid leukaemia | 16.28 | 15.28 | 28 | 127260 | 4173 | 70796983 |
Myoclonus | 16.26 | 15.28 | 14 | 127274 | 26341 | 70774815 |
Neoplasm recurrence | 16.24 | 15.28 | 27 | 127261 | 3914 | 70797242 |
Dementia | 16.24 | 15.28 | 10 | 127278 | 22355 | 70778801 |
Xerosis | 16.22 | 15.28 | 14 | 127274 | 1014 | 70800142 |
Colorectal cancer recurrent | 16.19 | 15.28 | 6 | 127282 | 79 | 70801077 |
Onycholysis | 16.13 | 15.28 | 18 | 127270 | 1785 | 70799371 |
Gastritis | 16.09 | 15.28 | 35 | 127253 | 44556 | 70756600 |
Hyperthyroidism | 16.01 | 15.28 | 8 | 127280 | 20083 | 70781073 |
Hepatic fibrosis | 15.98 | 15.28 | 35 | 127253 | 6232 | 70794924 |
Neuronal neuropathy | 15.97 | 15.28 | 3 | 127285 | 0 | 70801156 |
Tunnel vision | 15.94 | 15.28 | 15 | 127273 | 1216 | 70799940 |
Ventricular fibrillation | 15.91 | 15.28 | 93 | 127195 | 27018 | 70774138 |
Movement disorder | 15.91 | 15.28 | 12 | 127276 | 24117 | 70777039 |
Colonic fistula | 15.89 | 15.28 | 11 | 127277 | 574 | 70800582 |
Hypertriglyceridaemia | 15.87 | 15.28 | 52 | 127236 | 11759 | 70789397 |
Back pain | 15.85 | 15.28 | 368 | 126920 | 270784 | 70530372 |
Ankle fracture | 15.82 | 15.28 | 4 | 127284 | 15340 | 70785816 |
Sputum discoloured | 15.81 | 15.28 | 7 | 127281 | 18844 | 70782312 |
Lymphadenopathy mediastinal | 15.73 | 15.28 | 27 | 127261 | 4018 | 70797138 |
Sepsis | 15.67 | 15.28 | 561 | 126727 | 243984 | 70557172 |
Gastric dilatation | 15.66 | 15.28 | 15 | 127273 | 1243 | 70799913 |
Red blood cell count decreased | 15.66 | 15.28 | 45 | 127243 | 52116 | 70749040 |
C-reactive protein increased | 15.65 | 15.28 | 125 | 127163 | 110392 | 70690764 |
Tumour marker increased | 15.65 | 15.28 | 26 | 127262 | 3768 | 70797388 |
Gastric varices | 15.59 | 15.28 | 11 | 127277 | 592 | 70800564 |
Gastrointestinal stoma output increased | 15.53 | 15.28 | 8 | 127280 | 241 | 70800915 |
Live birth | 15.40 | 15.28 | 3 | 127285 | 13776 | 70787380 |
Pallor | 15.40 | 15.28 | 126 | 127162 | 40848 | 70760308 |
Chronic kidney disease | 15.33 | 15.28 | 57 | 127231 | 61000 | 70740156 |
Coombs positive haemolytic anaemia | 15.32 | 15.28 | 13 | 127275 | 920 | 70800236 |
Sense of oppression | 15.30 | 15.28 | 16 | 127272 | 1474 | 70799682 |
None
Source | Code | Description |
---|---|---|
ATC | L01XA03 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Platinum compounds |
FDA EXT | N0000175073 | Platinum-containing Compounds |
FDA EPC | N0000175413 | Platinum-based Drug |
MeSH PA | D000970 | Antineoplastic Agents |
CHEBI has role | CHEBI:25435 | mutagens |
CHEBI has role | CHEBI:35610 | antineoplastic agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Metastasis from malignant tumor of colon | indication | 314998002 | |
Small intestine cancer | indication | 363509000 | DOID:10154 |
Lymph Node Positive Colorectal Carcinoma | indication | ||
Malignant tumor of colon | off-label use | 363406005 | DOID:219 |
Malignant tumor of testis | off-label use | 363449006 | DOID:2998 |
Adenocarcinoma of pancreas | off-label use | 700423003 | DOID:4074 |
Fibrosis of lung | contraindication | 51615001 | DOID:3770 |
Interstitial pneumonia | contraindication | 64667001 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Liver function tests abnormal | contraindication | 166603001 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Pregnancy, function | contraindication | 289908002 | |
Peripheral nerve disease | contraindication | 302226006 | |
Breastfeeding (mother) | contraindication | 413712001 |
None
None
None
None
None
None
ID | Source |
---|---|
4021355 | VUID |
N0000148774 | NUI |
D01790 | KEGG_DRUG |
4021355 | VANDF |
C0069717 | UMLSCUI |
CHEBI:31941 | CHEBI |
1PT | PDB_CHEM_ID |
CHEMBL414804 | ChEMBL_ID |
D000077150 | MESH_DESCRIPTOR_UI |
DB00526 | DRUGBANK_ID |
7433 | IUPHAR_LIGAND_ID |
6012 | INN_ID |
04ZR38536J | UNII |
9887053 | PUBCHEM_CID |
32592 | RXNORM |
165344 | MMSL |
16916 | MMSL |
d04811 | MMSL |
007166 | NDDF |
327032007 | SNOMEDCT_US |
395814003 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-3985 | INJECTION, SOLUTION, CONCENTRATE | 50 mg | INTRAVENOUS | NDA | 28 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-3985 | INJECTION, SOLUTION, CONCENTRATE | 50 mg | INTRAVENOUS | NDA | 28 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-3986 | INJECTION, SOLUTION, CONCENTRATE | 100 mg | INTRAVENOUS | NDA | 28 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-3986 | INJECTION, SOLUTION, CONCENTRATE | 100 mg | INTRAVENOUS | NDA | 28 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3315 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 29 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3317 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 29 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-9315 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 28 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-9317 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 28 sections |
OXALIPLATIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1725 | INJECTION, SOLUTION, CONCENTRATE | 5 mg | INTRAVENOUS | NDA AUTHORIZED GENERIC | 33 sections |
OXALIPLATIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1727 | INJECTION, SOLUTION, CONCENTRATE | 5 mg | INTRAVENOUS | NDA AUTHORIZED GENERIC | 33 sections |
OXALIPLATIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1731 | INJECTION, SOLUTION, CONCENTRATE | 5 mg | INTRAVENOUS | NDA AUTHORIZED GENERIC | 33 sections |
OXALIPLATIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1733 | INJECTION, SOLUTION, CONCENTRATE | 5 mg | INTRAVENOUS | NDA AUTHORIZED GENERIC | 33 sections |
oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-727 | INJECTION | 5 mg | INTRAVENOUS | ANDA | 27 sections |
oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-728 | INJECTION | 5 mg | INTRAVENOUS | ANDA | 27 sections |
oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-332 | INJECTION, SOLUTION, CONCENTRATE | 5 mg | INTRAVENOUS | ANDA | 30 sections |
oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-233 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 28 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43066-014 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 28 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43066-018 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 28 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45963-611 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 5 mg | INTRAVENOUS | ANDA | 20 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45963-611 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 5 mg | INTRAVENOUS | ANDA | 20 sections |
Oxaliplatin | Human Prescription Drug Label | 1 | 47335-046 | INJECTION, SOLUTION, CONCENTRATE | 50 mg | INTRAVENOUS | ANDA | 27 sections |
Oxaliplatin | Human Prescription Drug Label | 1 | 47335-047 | INJECTION, SOLUTION, CONCENTRATE | 100 mg | INTRAVENOUS | ANDA | 27 sections |
Oxaliplatin | Human Prescription Drug Label | 1 | 47335-176 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 50 mg | INTRAVENOUS | ANDA | 28 sections |
Oxaliplatin | Human Prescription Drug Label | 1 | 47335-178 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 100 mg | INTRAVENOUS | ANDA | 28 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50742-405 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 26 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50742-406 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | ANDA | 26 sections |
Oxaliplatin | Human Prescription Drug Label | 1 | 55150-331 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 29 sections |
Oxaliplatin | Human Prescription Drug Label | 1 | 55150-332 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 29 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 57277-001 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 26 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 57277-002 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 26 sections |