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Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
antineoplastic agents, platinum derivatives	4210	61825-94-3

Description:

Molecule	Description
Synonyms: oxaliplatin oxalatoplatin oxalatoplatinum elplat	An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS. Molecular weight: 397.29 Formula: C8H14N2O4Pt CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

oxaliplatin
oxalatoplatin
oxalatoplatinum
elplat

An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS.

Molecular weight: 397.29
Formula: C8H14N2O4Pt
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	6 mg/mL	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	8.13 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution)	0.50 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	0.10 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.13 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	58.92 hours	Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
Aug. 9, 2002	FDA
March 18, 2005	PMDA	Yakult Honsha

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Neuropathy peripheral	1979.45	17.89	1367	85261	135603	90406216
Disease progression	1837.04	17.89	1377	85251	155238	90386581
Neutropenia	1488.02	17.89	1422	85206	223482	90318337
Laryngospasm	1284.51	17.89	347	86281	2986	90538833
Neurotoxicity	1045.44	17.89	477	86151	20990	90520829
Thrombocytopenia	1035.82	17.89	1131	85497	207594	90334225
Diarrhoea	943.16	17.89	2471	84157	936719	89605100
Myelosuppression	877.95	17.89	579	86049	53012	90488807
Stridor	636.61	17.89	220	86408	4573	90537246
Mucosal inflammation	632.74	17.89	488	86140	57137	90484682
Palmar-plantar erythrodysaesthesia syndrome	564.08	17.89	345	86283	27678	90514141
Arteriospasm coronary	538.71	17.89	197	86431	4853	90536966
Vomiting	521.20	17.89	1793	84835	786500	89755319
Polyneuropathy	494.41	17.89	278	86350	19063	90522756
Dermatitis acneiform	449.88	17.89	184	86444	6170	90535649
Paraesthesia	437.42	17.89	825	85803	249501	90292318
Bronchospasm	432.28	17.89	261	86367	20448	90521371
Dysarthria	425.94	17.89	379	86249	54103	90487716
Skin toxicity	425.02	17.89	180	86448	6599	90535220
Nausea	415.45	17.89	2121	84507	1108195	89433624
Joint swelling	408.50	17.89	17	86611	503283	90038536
Arthralgia	405.62	17.89	121	86507	778401	89763418
Dysaesthesia pharynx	394.04	17.89	79	86549	129	90541690
Non-cirrhotic portal hypertension	390.05	17.89	87	86541	293	90541526
Febrile neutropenia	390.00	17.89	608	86020	157741	90384078
Peripheral sensory neuropathy	383.54	17.89	184	86444	9066	90532753
Malignant neoplasm progression	371.92	17.89	484	86144	106386	90435433
Bone marrow failure	360.39	17.89	276	86352	31945	90509874
Throat tightness	343.99	17.89	259	86369	29225	90512594
Arthropathy	328.88	17.89	4	86624	366238	90175581
Metastases to liver	324.91	17.89	248	86380	28559	90513260
Systemic lupus erythematosus	320.41	17.89	5	86623	361891	90179928
Enteritis	301.37	17.89	162	86466	10159	90531660
Swelling	298.87	17.89	28	86600	419030	90122789
Gastrointestinal toxicity	297.34	17.89	156	86472	9311	90532508
Pemphigus	296.05	17.89	3	86625	326861	90214958
Sinusitis	287.17	17.89	9	86619	343079	90198740
Pain	280.24	17.89	325	86303	996016	89545803
Glossodynia	278.48	17.89	6	86622	321773	90220046
Nasopharyngitis	277.93	17.89	32	86596	407072	90134747
Leukopenia	275.16	17.89	406	86222	100304	90441515
Headache	272.25	17.89	255	86373	862491	89679328
Contraindicated product administered	269.37	17.89	8	86620	320131	90221688
Dyspnoea	268.57	17.89	1594	85034	879361	89662458
Weight increased	265.88	17.89	41	86587	417886	90123933
Neutrophil count decreased	261.38	17.89	332	86296	71200	90470619
Haematotoxicity	259.04	17.89	157	86471	12378	90529441
Wound	257.01	17.89	7	86621	302973	90238846
Venoocclusive liver disease	247.81	17.89	119	86509	5874	90535945
Erythema	236.60	17.89	612	86016	228634	90313185
Product dose omission issue	232.67	17.89	11	86617	291676	90250143
Therapy partial responder	227.34	17.89	180	86448	21863	90519956
Laryngeal oedema	220.70	17.89	115	86513	6766	90535053
Chills	220.31	17.89	427	86201	131554	90410265
Hypokalaemia	217.39	17.89	423	86205	130693	90411126
Lower respiratory tract infection	215.57	17.89	5	86623	250654	90291165
Portal hypertension	214.80	17.89	100	86528	4601	90537218
Abdominal discomfort	211.37	17.89	96	86532	477232	90064587
Maternal exposure during pregnancy	208.14	17.89	45	86583	360018	90181801
Asthma	207.59	17.89	5	86623	242155	90299664
Therapeutic product effect decreased	207.59	17.89	15	86613	277556	90264263
Anaemia	207.38	17.89	774	85854	352028	90189791
Ascites	205.92	17.89	241	86387	47499	90494320
Flushing	205.54	17.89	331	86297	88160	90453659
Pericarditis	203.76	17.89	14	86614	270137	90271682
Gastrointestinal perforation	203.69	17.89	94	86534	4238	90537581
Helicobacter infection	201.26	17.89	3	86625	226847	90314972
Posterior reversible encephalopathy syndrome	200.02	17.89	168	86460	22171	90519648
Peripheral swelling	199.24	17.89	73	86555	413033	90128786
Psoriatic arthropathy	198.52	17.89	4	86624	228331	90313488
Duodenal ulcer perforation	196.00	17.89	3	86625	221285	90320534
Depression	192.21	17.89	29	86599	300572	90241247
Type I hypersensitivity	191.76	17.89	89	86539	4066	90537753
Dehydration	189.24	17.89	508	86120	193939	90347880
Nodular regenerative hyperplasia	185.10	17.89	54	86574	629	90541190
Neoplasm progression	184.30	17.89	220	86408	44266	90497553
Blood cholesterol increased	179.43	17.89	4	86624	208008	90333811
Anaphylactic shock	178.73	17.89	184	86444	31433	90510386
Paronychia	177.69	17.89	105	86523	7901	90533918
Cardiotoxicity	176.56	17.89	119	86509	11270	90530549
Type 2 diabetes mellitus	174.95	17.89	4	86624	203240	90338579
Abdominal pain	174.02	17.89	794	85834	394927	90146892
Hepatic enzyme increased	173.49	17.89	64	86564	360672	90181147
Injury	169.42	17.89	4	86624	197345	90344474
Enterocolitis	168.37	17.89	112	86516	10378	90531441
Folliculitis	165.24	17.89	7	86621	204346	90337473
Drug ineffective	164.71	17.89	724	85904	1383574	89158245
Musculoskeletal stiffness	163.51	17.89	41	86587	296491	90245328
Immune thrombocytopenia	161.96	17.89	120	86508	13206	90528613
Colorectal cancer metastatic	161	17.89	51	86577	798	90541021
Dysphonia	158.97	17.89	245	86383	62839	90478980
Splenomegaly	158.46	17.89	117	86511	12807	90529012
Speech disorder	157.73	17.89	206	86422	45379	90496440
Fall	153.24	17.89	141	86487	481669	90060150
Insomnia	152.38	17.89	64	86564	333410	90208409
Interstitial lung disease	152.37	17.89	267	86361	76138	90465681
Hyperammonaemia	151.83	17.89	88	86540	6387	90535432
Asthenia	150.03	17.89	947	85681	532804	90009015
Mobility decreased	149.68	17.89	29	86599	250705	90291114
Contusion	147.98	17.89	30	86598	251186	90290633
Stress cardiomyopathy	146.24	17.89	113	86515	13242	90528577
Dysphagia	144.92	17.89	327	86301	111951	90429868
Product use issue	143.39	17.89	68	86560	329851	90211968
Blister	143.03	17.89	34	86594	254964	90286855
Hypomagnesaemia	142.50	17.89	173	86455	35415	90506404
Alopecia	141.38	17.89	159	86469	494912	90046907
Anaphylactic reaction	139.72	17.89	278	86350	87246	90454573
Platelet count decreased	139.44	17.89	364	86264	136605	90405214
Metastases to lung	138.52	17.89	118	86510	15873	90525946
Tongue oedema	132.89	17.89	76	86552	5378	90536441
Hyperhidrosis	132.43	17.89	356	86272	135949	90405870
Sleep disorder	129.11	17.89	18	86610	198012	90343807
Hyperthermia	127.69	17.89	94	86534	10241	90531578
Decreased appetite	125.56	17.89	699	85929	375841	90165978
Dysaesthesia	124.76	17.89	72	86556	5183	90536636
Impaired healing	124.12	17.89	35	86593	234164	90307655
Exposure during pregnancy	123.83	17.89	37	86591	238373	90303446
Metastases to peritoneum	123.49	17.89	66	86562	4089	90537730
Anastomotic leak	123.25	17.89	39	86589	608	90541211
Arthritis	122.34	17.89	10	86618	167305	90374514
Drug intolerance	122.12	17.89	149	86479	447442	90094377
Intestinal obstruction	121.07	17.89	163	86465	36968	90504851
Discomfort	120.02	17.89	56	86572	274279	90267540
Treatment failure	118.35	17.89	72	86556	303856	90237963
Intestinal perforation	117.32	17.89	101	86527	13780	90528039
Large intestine perforation	117.00	17.89	87	86541	9625	90532194
Cytokine release syndrome	115.29	17.89	138	86490	27835	90513984
Varices oesophageal	115.05	17.89	61	86567	3718	90538101
Bronchitis	115.04	17.89	8	86620	152919	90388900
Diffuse large B-cell lymphoma recurrent	113.28	17.89	59	86569	3467	90538352
Migraine	111.56	17.89	23	86605	190369	90351450
Memory impairment	111.18	17.89	26	86602	197218	90344601
Bursitis	108.13	17.89	4	86624	131650	90410169
Band sensation	107.70	17.89	41	86587	1132	90540687
Tachycardia	107.06	17.89	363	86265	157310	90384509
Hyperammonaemic encephalopathy	106.78	17.89	52	86576	2647	90539172
Pain in extremity	105.85	17.89	167	86461	450362	90091457
Neuromyotonia	105.26	17.89	22	86606	49	90541770
Injection site pain	103.83	17.89	20	86608	173679	90368140
Blood lactate dehydrogenase increased	103.72	17.89	126	86502	25806	90516013
Oxygen saturation decreased	103.65	17.89	280	86348	107203	90434616
Paraesthesia oral	101.73	17.89	138	86490	31521	90510298
Hospitalisation	101.53	17.89	5	86623	128095	90413724
Focal nodular hyperplasia	100.82	17.89	35	86593	737	90541082
Influenza	99.96	17.89	9	86619	139255	90402564
Pancytopenia	99.11	17.89	296	86332	119967	90421852
Tumour perforation	98.56	17.89	24	86604	129	90541690
Evans syndrome	98.09	17.89	29	86599	355	90541464
Gait inability	93.85	17.89	14	86614	146442	90395377
Extravasation	93.52	17.89	49	86579	2915	90538904
Chest discomfort	91.69	17.89	316	86312	138049	90403770
Type II hypersensitivity	89.55	17.89	18	86610	30	90541789
Colitis	88.32	17.89	202	86426	69740	90472079
Ileus	87.61	17.89	93	86535	16453	90525366
Drug hypersensitivity	87.61	17.89	196	86432	463413	90078406
Condition aggravated	86.86	17.89	286	86342	595259	89946560
Road traffic accident	85.94	17.89	4	86624	107622	90434197
Cytopenia	85.25	17.89	94	86534	17355	90524464
Obesity	84.00	17.89	4	86624	105503	90436316
Hepatic failure	83.32	17.89	142	86486	39586	90502233
Lip dry	83.14	17.89	3	86625	100952	90440867
Off label use	82.86	17.89	1495	85133	1100757	89441062
Upper respiratory tract infection	82.83	17.89	12	86616	128306	90413513
Confusional state	80.79	17.89	154	86474	386051	90155768
Infection	80.55	17.89	139	86489	361955	90179864
Hypertensive crisis	80.39	17.89	92	86536	17692	90524127
Steatohepatitis	80.28	17.89	30	86598	786	90541033
Hypercholesterolaemia	79.76	17.89	4	86624	100888	90440931
Neutropenic colitis	78.23	17.89	49	86579	4094	90537725
Peritonitis	77.59	17.89	95	86533	19610	90522209
White blood cell count decreased	77.53	17.89	341	86287	166768	90375051
Pulmonary embolism	77.47	17.89	288	86340	130532	90411287
Metastases to ovary	77.05	17.89	26	86602	501	90541318
Sensation of foreign body	76.62	17.89	57	86571	6309	90535510
Tachypnoea	76.36	17.89	98	86530	21211	90520608
Gait disturbance	76.08	17.89	82	86546	260414	90281405
Osteoporosis	75.76	17.89	4	86624	96527	90445292
Infusion related hypersensitivity reaction	74.98	17.89	27	86601	635	90541184
Septic shock	73.98	17.89	212	86416	83948	90457871
Hypoaesthesia oral	72.71	17.89	82	86546	15518	90526301
Disseminated intravascular coagulation	72.43	17.89	96	86532	21442	90520377
Acute coronary syndrome	72.35	17.89	69	86559	10744	90531075
Pneumonia	72.23	17.89	339	86289	637720	89904099
Injection site reaction	71.69	17.89	4	86624	92076	90449743
Injection site erythema	71.68	17.89	6	86622	98496	90443323
Hypoalbuminaemia	71.45	17.89	82	86546	15815	90526004
Haemolytic anaemia	71.44	17.89	71	86557	11626	90530193
Gastric varices haemorrhage	71.41	17.89	19	86609	153	90541666
Night sweats	70.54	17.89	18	86610	128748	90413071
Laryngeal dyspnoea	70.43	17.89	20	86608	210	90541609
Cholinergic syndrome	69.98	17.89	26	86602	670	90541149
Inflammation	69.91	17.89	42	86586	178550	90363269
Intentional product misuse	69.43	17.89	4	86624	89600	90452219
Laryngeal discomfort	69.00	17.89	23	86605	426	90541393
Sciatica	69.00	17.89	8	86620	101374	90440445
Intentional product use issue	68.21	17.89	64	86564	216828	90324991
Metastases to meninges	67.59	17.89	43	86585	3692	90538127
Anxiety	66.99	17.89	121	86507	309651	90232168
Wound infection	66.29	17.89	11	86617	106391	90435428
Fluid retention	65.12	17.89	5	86623	88086	90453733
Hepatic function abnormal	64.42	17.89	139	86489	46149	90495670
Feeling hot	63.30	17.89	191	86437	77817	90464002
Anaphylactoid reaction	62.91	17.89	44	86584	4424	90537395
Drug abuse	62.83	17.89	4	86624	82343	90459476
Ocular toxicity	62.24	17.89	27	86601	1050	90540769
Dysgeusia	62.20	17.89	148	86480	52412	90489407
Cold dysaesthesia	62.18	17.89	12	86616	14	90541805
Inappropriate schedule of product administration	61.92	17.89	33	86595	149900	90391919
Peripheral venous disease	61.37	17.89	5	86623	83916	90457903
Adverse event	61.34	17.89	18	86610	117400	90424419
Tremor	61.04	17.89	299	86329	152874	90388945
Carcinoembryonic antigen increased	60.63	17.89	34	86594	2316	90539503
Thrombotic microangiopathy	60.54	17.89	75	86553	15668	90526151
Suicide attempt	59.56	17.89	3	86625	75396	90466423
Chemical peritonitis	59.38	17.89	15	86613	96	90541723
Stress	59.11	17.89	5	86623	81390	90460429
Congestive cardiomyopathy	59.10	17.89	52	86576	7302	90534517
Oropharyngeal discomfort	58.80	17.89	53	86575	7682	90534137
Gastrointestinal anastomotic leak	58.73	17.89	18	86610	251	90541568
Enterocutaneous fistula	58.32	17.89	29	86599	1545	90540274
Choking sensation	58.27	17.89	40	86588	3902	90537917
Suicidal ideation	58.15	17.89	3	86625	73852	90467967
Multiple organ dysfunction syndrome	57.99	17.89	170	86458	68166	90473653
Respiratory distress	57.72	17.89	120	86508	38826	90502993
Hydronephrosis	57.48	17.89	65	86563	12337	90529482
Oesophageal varices haemorrhage	56.79	17.89	28	86600	1464	90540355
Hypovolaemic shock	56.69	17.89	50	86578	7044	90534775
Overdose	56.43	17.89	41	86587	157668	90384151
Lung disorder	56.24	17.89	37	86591	149846	90391973
Prescribed underdose	56.19	17.89	4	86624	75015	90466804
Cholangitis	56.16	17.89	50	86578	7132	90534687
Dyspepsia	56.06	17.89	64	86564	198096	90343723
Dry mouth	55.91	17.89	56	86572	184003	90357816
Hyperpyrexia	55.90	17.89	42	86586	4719	90537100
Musculoskeletal pain	55.67	17.89	49	86579	171202	90370617
Mucosal toxicity	55.50	17.89	19	86609	383	90541436
Proteinuria	55.24	17.89	88	86540	23203	90518616
Urticaria	55.19	17.89	137	86491	312597	90229222
Periportal sinus dilatation	54.85	17.89	10	86618	6	90541813
Diffuse large B-cell lymphoma refractory	54.64	17.89	29	86599	1771	90540048
Disease recurrence	54.62	17.89	115	86513	37538	90504281
Suffocation feeling	54.48	17.89	28	86600	1600	90540219
Acute respiratory distress syndrome	54.27	17.89	98	86530	28588	90513231
Xeroderma	53.77	17.89	18	86610	338	90541481
Acute kidney injury	53.56	17.89	504	86124	319883	90221936
Leukoencephalopathy	52.84	17.89	41	86587	4832	90536987
Metastasis	52.56	17.89	45	86583	6092	90535727
Cyanosis	52.45	17.89	78	86550	19377	90522442
Live birth	51.98	17.89	7	86621	79100	90462719
Loss of personal independence in daily activities	51.88	17.89	33	86595	136072	90405747
Pharyngeal paraesthesia	51.20	17.89	34	86594	3140	90538679
Amnesia	50.84	17.89	20	86608	108485	90433334
Respiratory failure	50.68	17.89	236	86392	118182	90423637
Hyperbilirubinaemia	49.79	17.89	64	86564	13872	90527947
General physical health deterioration	48.99	17.89	537	86091	354578	90187241
Gastrooesophageal reflux disease	48.94	17.89	52	86576	166285	90375534
Gastric perforation	48.93	17.89	28	86600	1983	90539836
Grip strength decreased	48.71	17.89	14	86614	92562	90449257
Cardiac failure congestive	48.24	17.89	17	86611	98677	90443142
Pyrexia	48.03	17.89	892	85736	659593	89882226
Illness	47.79	17.89	10	86618	81959	90459860
Rash pustular	47.58	17.89	48	86580	8001	90533818
Palmar erythema	47.55	17.89	27	86601	1884	90539935
Oedema	47.19	17.89	74	86554	200221	90341598
Rectal perforation	46.84	17.89	18	86610	510	90541309
Trichomegaly	46.57	17.89	12	86616	84	90541735
Lymphoma	46.35	17.89	61	86567	13530	90528289
Colon cancer metastatic	46.29	17.89	24	86604	1397	90540422
Cardiogenic shock	45.54	17.89	83	86545	24385	90517434
Thrombocytopenic purpura	45.52	17.89	26	86602	1835	90539984
Neutrophil count abnormal	45.35	17.89	35	86593	4093	90537726
Abdominal abscess	45.12	17.89	39	86589	5348	90536471
Hypotension	44.84	17.89	492	86136	324905	90216914
Deep vein thrombosis	44.80	17.89	190	86438	91430	90450389
Trismus	44.69	17.89	37	86591	4784	90537035
Medication error	44.17	17.89	13	86615	84639	90457180
Peripheral motor neuropathy	44.11	17.89	26	86602	1947	90539872
Metastases to spleen	43.90	17.89	14	86614	224	90541595
Dihydropyrimidine dehydrogenase deficiency	43.53	17.89	12	86616	112	90541707
Stomal varices	42.61	17.89	8	86620	7	90541812
Liver function test increased	42.54	17.89	14	86614	84841	90456978
Fatigue	42.19	17.89	814	85814	1153209	89388610
Stoma site haemorrhage	41.87	17.89	22	86606	1316	90540503
Swollen tongue	41.58	17.89	117	86511	45839	90495980
Autoimmune haemolytic anaemia	41.58	17.89	38	86590	5607	90536212
Immune-mediated hepatitis	41.47	17.89	29	86599	2915	90538904
Paralysis	41.46	17.89	53	86575	11425	90530394
Somnolence	41.41	17.89	86	86542	208998	90332821
Eyelid ptosis	41.40	17.89	47	86581	8959	90532860
Large intestinal obstruction	41.21	17.89	28	86600	2686	90539133
Splenic artery thrombosis	41.03	17.89	10	86618	54	90541765
Hepatic cytolysis	40.92	17.89	91	86537	30825	90510994
Adverse drug reaction	40.89	17.89	31	86597	116670	90425149
Administration site extravasation	40.71	17.89	21	86607	1209	90540610
Sepsis	40.20	17.89	302	86326	179512	90362307
Underdose	40.11	17.89	3	86625	54014	90487805
Anastomotic fistula	39.97	17.89	9	86619	32	90541787
Injection site pruritus	39.95	17.89	3	86625	53831	90487988
Incorrect dose administered	39.61	17.89	13	86615	78917	90462902
Cholestasis	39.52	17.89	99	86529	36200	90505619
Vascular pain	39.46	17.89	19	86609	943	90540876
Gastrointestinal stoma complication	39.23	17.89	26	86602	2393	90539426
Chronic obstructive pulmonary disease	39.15	17.89	11	86617	73818	90468001
Pharyngeal dyskinesia	39.14	17.89	9	86619	36	90541783
Blood lactate dehydrogenase abnormal	38.84	17.89	15	86613	431	90541388
Cough	38.80	17.89	201	86427	368761	90173058
Cold sweat	38.74	17.89	57	86571	14024	90527795
Acute motor axonal neuropathy	38.56	17.89	9	86619	39	90541780
Toxic leukoencephalopathy	38.52	17.89	18	86610	835	90540984
Retching	38.23	17.89	67	86561	19092	90522727
Hypophagia	38.07	17.89	97	86531	35840	90505979
Portal hypertensive gastropathy	37.93	17.89	19	86609	1028	90540791
Neck pain	37.77	17.89	32	86596	113931	90427888
Cystitis radiation	37.53	17.89	10	86618	81	90541738
Abortion spontaneous	37.45	17.89	4	86624	54052	90487767
Electrolyte imbalance	37.36	17.89	75	86553	23670	90518149
Portal shunt	37.08	17.89	8	86620	22	90541797
Neutropenic sepsis	36.96	17.89	64	86564	18066	90523753
Granulocyte count decreased	36.53	17.89	25	86603	2427	90539392
Metastases to lymph nodes	36.11	17.89	50	86578	11639	90530180
Vasospasm	35.99	17.89	18	86610	971	90540848
Iris cyst	35.72	17.89	6	86622	0	90541819
Myalgia	35.55	17.89	71	86557	175054	90366765
Wheezing	35.54	17.89	113	86515	237967	90303852
Lupus-like syndrome	35.47	17.89	3	86625	48843	90492976
Factor VII deficiency	35.31	17.89	9	86619	60	90541759
Immune-mediated adverse reaction	35.26	17.89	17	86611	846	90540973
Tumour ulceration	35.19	17.89	12	86616	239	90541580
Encephalopathy	35.14	17.89	111	86517	46333	90495486
Loss of consciousness	35.08	17.89	242	86386	139996	90401823
Hepatitis B core antibody positive	34.88	17.89	13	86615	338	90541481
Formication	34.80	17.89	32	86596	4759	90537060
Rectal cancer recurrent	34.79	17.89	8	86620	32	90541787
Anorectal varices haemorrhage	34.70	17.89	7	86621	12	90541807
Hypertrichosis	34.41	17.89	20	86608	1459	90540360
Tongue disorder	34.37	17.89	47	86581	10813	90531006
Pancreatitis acute	34.35	17.89	87	86541	32028	90509791
Chemotherapy toxicity attenuation	34.34	17.89	7	86621	13	90541806
Left ventricular failure	34.31	17.89	37	86591	6663	90535156
Asphyxia	34.24	17.89	38	86590	7065	90534754
Colon cancer recurrent	34.22	17.89	9	86619	69	90541750
Retroperitoneal lymphadenopathy	34.20	17.89	16	86612	744	90541075
Cardiac ventricular thrombosis	33.66	17.89	18	86610	1116	90540703
Haematemesis	33.64	17.89	89	86539	33637	90508182
Tumour lysis syndrome	33.40	17.89	47	86581	11105	90530714
Ileus paralytic	33.17	17.89	32	86596	5053	90536766
Metastases to diaphragm	33.17	17.89	8	86620	41	90541778
ECG signs of myocardial ischaemia	33.04	17.89	9	86619	80	90541739
Ileal perforation	33.03	17.89	14	86614	514	90541305
Nail disorder	32.84	17.89	8	86620	59059	90482760
Short-bowel syndrome	32.78	17.89	15	86613	663	90541156
Ill-defined disorder	32.59	17.89	81	86547	184810	90357009
Diaphragmatic paralysis	32.40	17.89	15	86613	681	90541138
C-reactive protein increased	32.34	17.89	79	86549	181310	90360509
Wrong technique in product usage process	32.22	17.89	14	86614	71557	90470262
Bladder tamponade	32.21	17.89	10	86618	146	90541673
Laryngitis	32.16	17.89	5	86623	50748	90491071
Vocal cord paralysis	32.06	17.89	23	86605	2407	90539412
Fulminant type 1 diabetes mellitus	32.01	17.89	16	86612	862	90540957
Product quality issue	31.96	17.89	18	86610	79307	90462512
Haemolysis	31.85	17.89	40	86588	8470	90533349
Ear pain	31.72	17.89	8	86620	57694	90484125
Protein-losing gastroenteropathy	31.70	17.89	12	86616	326	90541493
Immune effector cell-associated neurotoxicity syndrome	31.57	17.89	33	86595	5735	90536084
Agranulocytosis	31.55	17.89	89	86539	34913	90506906
Acute polyneuropathy	31.44	17.89	13	86615	448	90541371
Blood pressure fluctuation	31.38	17.89	6	86622	52407	90489412
Hepatectomy	31.30	17.89	10	86618	161	90541658
K-ras gene mutation	31.28	17.89	7	86621	24	90541795
Haemolytic uraemic syndrome	31.24	17.89	24	86604	2787	90539032
Larynx irritation	31.02	17.89	10	86618	166	90541653
Pseudocirrhosis	30.91	17.89	16	86612	928	90540891
Skin fissures	30.70	17.89	64	86564	20745	90521074
Pancreatic haemorrhage	30.64	17.89	7	86621	27	90541792
Ventricular fibrillation	30.51	17.89	51	86577	13993	90527826
Hepatocellular injury	30.50	17.89	78	86550	28880	90512939
Atypical haemolytic uraemic syndrome	30.18	17.89	16	86612	975	90540844
Subacute cutaneous lupus erythematosus	30.14	17.89	26	86602	3556	90538263
Colitis ulcerative	30.11	17.89	10	86618	60256	90481563
Tumour necrosis	30.03	17.89	16	86612	985	90540834
Sedation	29.95	17.89	5	86623	48166	90493653
Bone marrow oedema syndrome	29.90	17.89	8	86620	66	90541753
Anaphylactic transfusion reaction	29.77	17.89	5	86623	0	90541819
Subileus	29.75	17.89	26	86602	3618	90538201
Herpes zoster	29.65	17.89	28	86600	94616	90447203
Colorectal cancer recurrent	29.49	17.89	6	86622	11	90541808
Abdominal sepsis	29.44	17.89	18	86610	1441	90540378
Bronchostenosis	29.39	17.89	13	86615	530	90541289
Injection site paraesthesia	29.24	17.89	14	86614	686	90541133
Perforation	28.92	17.89	20	86608	1974	90539845
Acute myocardial infarction	28.83	17.89	86	86542	34804	90507015
Influenza like illness	28.77	17.89	21	86607	80590	90461229
Intravascular haemolysis	28.63	17.89	12	86616	428	90541391
Muscle rigidity	28.50	17.89	50	86578	14259	90527560
Nasal congestion	28.16	17.89	23	86605	83391	90458428
Gastrointestinal stoma output increased	27.96	17.89	13	86615	596	90541223
Nicotinic acid deficiency	27.84	17.89	8	86620	88	90541731
Eczema	27.80	17.89	8	86620	52862	90488957
Inferior vena cava stenosis	27.68	17.89	6	86622	17	90541802
Intestinal ischaemia	27.44	17.89	38	86590	8845	90532974
Motion sickness	27.32	17.89	16	86612	1184	90540635
Peritoneal disorder	27.25	17.89	13	86615	632	90541187
Mixed adenoneuroendocrine carcinoma	26.94	17.89	6	86622	20	90541799
Medical device site extravasation	26.83	17.89	5	86623	4	90541815
Biliary tract infection	26.76	17.89	14	86614	830	90540989
Azotaemia	26.45	17.89	29	86599	5319	90536500
Schistosomiasis	26.31	17.89	5	86623	5	90541814
Pallor	26.17	17.89	82	86546	34083	90507736
Mucosal necrosis	26.01	17.89	8	86620	113	90541706
Frequent bowel movements	25.85	17.89	11	86617	56924	90484895
Hypocalcaemia	25.67	17.89	94	86534	42274	90499545
Peripheral nerve injury	25.57	17.89	13	86615	726	90541093
Post embolisation syndrome	25.40	17.89	5	86623	7	90541812
Catheter site bruise	25.37	17.89	12	86616	572	90541247
Small intestinal obstruction	25.34	17.89	60	86568	21174	90520645
Necrotic lymphadenopathy	25.32	17.89	8	86620	124	90541695
Onychomycosis	25.30	17.89	3	86625	37373	90504446
Feeling abnormal	25.21	17.89	79	86549	167156	90374663
Productive cough	25.09	17.89	22	86606	77041	90464778
Hemiparesis	24.95	17.89	77	86551	31742	90510077
Heart rate decreased	24.83	17.89	10	86618	53495	90488324
Immediate post-injection reaction	24.76	17.89	11	86617	453	90541366
Face oedema	24.76	17.89	63	86565	23255	90518564
Hepatic encephalopathy	24.72	17.89	46	86582	13726	90528093
Liver abscess	24.71	17.89	23	86605	3473	90538346
Metastases to bone marrow	24.71	17.89	12	86616	607	90541212
Toxic cardiomyopathy	24.48	17.89	10	86618	334	90541485
Rhinorrhoea	24.45	17.89	29	86599	88287	90453532
Lip oedema	24.42	17.89	26	86602	4613	90537206
Performance status decreased	24.35	17.89	25	86603	4255	90537564
Tonic clonic movements	24.34	17.89	17	86611	1705	90540114
Type IV hypersensitivity reaction	24.29	17.89	24	86604	3902	90537917
Jugular vein thrombosis	24.24	17.89	23	86605	3558	90538261
Amaurosis	24.15	17.89	13	86615	817	90541002
Monoparesis	24.06	17.89	18	86610	2009	90539810
Hemiparaesthesia	23.91	17.89	8	86620	150	90541669
Therapy interrupted	23.86	17.89	9	86619	50099	90491720
Hypertension	23.83	17.89	589	86039	456943	90084876
Diffuse large B-cell lymphoma	23.79	17.89	35	86593	8610	90533209
Papillary cystadenoma lymphomatosum	23.67	17.89	8	86620	155	90541664
Cachexia	23.65	17.89	31	86597	6847	90534972
Dry eye	23.55	17.89	13	86615	57918	90483901
Dysentery	23.51	17.89	14	86614	1068	90540751
Treatment noncompliance	23.47	17.89	10	86618	51717	90490102
Aphasia	23.47	17.89	92	86536	42720	90499099
Leukocytosis	23.38	17.89	74	86554	30916	90510903
Drug reaction with eosinophilia and systemic symptoms	23.37	17.89	6	86622	42752	90499067
Gastroenteritis aeromonas	23.16	17.89	6	86622	43	90541776
White blood cell count abnormal	23.03	17.89	32	86596	7472	90534347
Cutaneous lupus erythematosus	22.98	17.89	21	86607	3097	90538722
Acute promyelocytic leukaemia	22.96	17.89	14	86614	1115	90540704
Muscle spasms	22.91	17.89	353	86275	251530	90290289
Adenocarcinoma of colon	22.87	17.89	20	86608	2786	90539033
Catabolic state	22.70	17.89	6	86622	47	90541772
Left ventricular dysfunction	22.68	17.89	46	86582	14623	90527196
Hyperventilation	22.64	17.89	30	86598	6698	90535121
Temperature intolerance	22.63	17.89	41	86587	11989	90529830
Lymphatic duct injury	22.59	17.89	6	86622	48	90541771
Hypertransaminasaemia	22.56	17.89	48	86580	15777	90526042
Drug interaction	22.56	17.89	163	86465	276290	90265529
Pigmentation disorder	22.33	17.89	28	86600	5921	90535898
Rash	22.30	17.89	585	86043	795515	89746304
Neoplasm recurrence	22.19	17.89	21	86607	3238	90538581
Implant site dehiscence	22.16	17.89	5	86623	18	90541801
Feeling cold	22.04	17.89	67	86561	27398	90514421
Hyperchylomicronaemia	21.96	17.89	6	86622	54	90541765
Myopathy toxic	21.83	17.89	11	86617	603	90541216
Cataract	21.80	17.89	22	86606	72070	90469749
Balance disorder	21.79	17.89	37	86591	97043	90444776
Hepatic lesion	21.77	17.89	27	86601	5646	90536173
Renal tubular injury	21.66	17.89	14	86614	1235	90540584
Protein urine	21.64	17.89	12	86616	800	90541019
Ataxia	21.55	17.89	51	86577	17991	90523828
Microangiopathic haemolytic anaemia	21.54	17.89	12	86616	807	90541012
Colon cancer	21.48	17.89	38	86590	10906	90530913
Nephrolithiasis	21.47	17.89	10	86618	49075	90492744
Aortic intramural haematoma	21.40	17.89	7	86621	122	90541697
Hyperlipasaemia	21.38	17.89	12	86616	819	90541000
Embolism	21.36	17.89	35	86593	9446	90532373
Neutropenic infection	21.33	17.89	16	86612	1793	90540026
Oral dysaesthesia	21.29	17.89	7	86621	124	90541695
Gastrointestinal disorder	21.11	17.89	151	86477	256536	90285283
Anal squamous cell carcinoma	21.06	17.89	11	86617	650	90541169
Gastric varices	21.04	17.89	8	86620	220	90541599
Aortic thrombosis	21.03	17.89	14	86614	1298	90540521
Phrenic nerve paralysis	20.97	17.89	9	86619	341	90541478
Immune-mediated myocarditis	20.91	17.89	14	86614	1311	90540508
Altered state of consciousness	20.85	17.89	72	86556	31460	90510359
Growth of eyelashes	20.84	17.89	8	86620	226	90541593
Toxic erythema of chemotherapy	20.84	17.89	8	86620	226	90541593
Liver injury	20.81	17.89	88	86540	170479	90371340
Respiratory fatigue	20.74	17.89	7	86621	135	90541684
Xerophthalmia	20.71	17.89	11	86617	673	90541146
Aortitis	20.67	17.89	14	86614	1336	90540483
Pulmonary fibrosis	20.62	17.89	45	86583	107458	90434361
Skin reaction	20.61	17.89	51	86577	18502	90523317
Renal tubular disorder	20.58	17.89	20	86608	3187	90538632
Paraphilia	20.51	17.89	5	86623	27	90541792
Respiratory disorder	20.51	17.89	19	86609	64797	90477022
Hypocapnia	20.50	17.89	10	86618	511	90541308
Viral infection	20.46	17.89	7	86621	41407	90500412
Encapsulating peritoneal sclerosis	20.46	17.89	9	86619	362	90541457
Metastases to central nervous system	20.32	17.89	49	86579	17493	90524326
Metastatic neoplasm	20.24	17.89	24	86604	4791	90537028
Portal vein dilatation	20.21	17.89	5	86623	29	90541790
Dyslalia	20.21	17.89	11	86617	707	90541112
Lacrimation disorder	20.16	17.89	4	86624	6	90541813
Capillary nail refill test abnormal	20.11	17.89	6	86622	76	90541743
Unevaluable event	19.95	17.89	14	86614	54834	90486985
Weight decreased	19.88	17.89	250	86378	379660	90162159
Surgery	19.86	17.89	9	86619	44878	90496941
Gastrointestinal inflammation	19.73	17.89	28	86600	6668	90535151
Incorrect route of product administration	19.67	17.89	12	86616	50614	90491205
Hepatic vein stenosis	19.66	17.89	5	86623	33	90541786
Malignant ascites	19.63	17.89	12	86616	960	90540859
Diarrhoea haemorrhagic	19.62	17.89	36	86592	10627	90531192
Colitis ischaemic	19.43	17.89	39	86589	12307	90529512
Diabetes mellitus	19.39	17.89	20	86608	64855	90476964
Blood phosphorus decreased	19.38	17.89	24	86604	5010	90536809
Necrosis ischaemic	19.37	17.89	12	86616	983	90540836
Tumour haemorrhage	19.26	17.89	16	86612	2078	90539741
Terminal ileitis	19.23	17.89	13	86615	1237	90540582
Gastroenteritis viral	19.21	17.89	3	86625	30352	90511467
Subclavian vein thrombosis	19.12	17.89	16	86612	2100	90539719
Haematuria	19.09	17.89	75	86553	34862	90506957
Epistaxis	19.02	17.89	143	86485	84982	90456837
Blood glucose increased	19.00	17.89	39	86589	95207	90446612
Hypophosphataemia	18.85	17.89	43	86585	14811	90527008
Pulmonary sarcoidosis	18.77	17.89	13	86615	1286	90540533
Death	18.74	17.89	570	86058	455981	90085838
Oesophagitis	18.73	17.89	47	86581	17202	90524617
Vaginal cellulitis	18.70	17.89	6	86622	98	90541721
Pelvic fluid collection	18.69	17.89	12	86616	1047	90540772
Red cell fragmentation syndrome	18.61	17.89	5	86623	42	90541777
Hypothermia	18.57	17.89	44	86584	15531	90526288
Duodenal ulcer	18.54	17.89	33	86595	9519	90532300
Femoral artery embolism	18.40	17.89	5	86623	44	90541775
Amaurosis fugax	18.34	17.89	10	86618	645	90541174
Endometrial dysplasia	18.28	17.89	4	86624	12	90541807
Sense of oppression	18.27	17.89	12	86616	1088	90540731
Jaw operation	18.23	17.89	11	86617	860	90540959
Hereditary motor and sensory neuropathy	18.21	17.89	6	86622	107	90541712
Toxic encephalopathy	18.11	17.89	31	86597	8668	90533151
Device dislocation	18.02	17.89	4	86624	31478	90510341
Jaundice	17.92	17.89	70	86558	32447	90509372

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Neuropathy peripheral	2204.91	14.58	2022	119483	99831	42399999
Disease progression	1656.15	14.58	2040	119465	141616	42358214
Neurotoxicity	907.64	14.58	657	120848	22994	42476836
Diarrhoea	845.18	14.58	3050	118455	457799	42042031
Arteriospasm coronary	842.42	14.58	362	121143	4376	42495454
Neutropenia	803.23	14.58	1760	119745	197671	42302159
Skin toxicity	739.30	14.58	365	121140	6184	42493646
Palmar-plantar erythrodysaesthesia syndrome	713.75	14.58	538	120967	20044	42479786
Myelosuppression	689.83	14.58	706	120799	39755	42460075
Thrombocytopenia	671.22	14.58	1594	119911	188685	42311145
Dermatitis acneiform	606.93	14.58	338	121167	7401	42492429
Nausea	524.99	14.58	2376	119129	394423	42105407
Metastases to liver	511.81	14.58	402	121103	15924	42483906
Polyneuropathy	499.50	14.58	419	121086	18242	42481588
Erythema	488.72	14.58	1005	120500	107788	42392042
Paronychia	429.85	14.58	220	121285	4035	42495795
Vomiting	416.49	14.58	1780	119725	287943	42211887
Peripheral sensory neuropathy	395.55	14.58	269	121236	8493	42491337
Product dose omission issue	385.60	14.58	12	121493	154353	42345477
Venoocclusive liver disease	374.23	14.58	277	121228	10025	42489805
Chills	368.19	14.58	822	120683	93244	42406586
Interstitial lung disease	364.16	14.58	735	120770	77727	42422103
Portal hypertension	348.07	14.58	199	121306	4588	42495242
Therapy partial responder	302.93	14.58	328	121177	19693	42480137
Paraesthesia	302.14	14.58	655	120850	72804	42427026
Hypersensitivity	300.75	14.58	648	120857	71722	42428108
Arthralgia	298.96	14.58	106	121399	205132	42294698
Haematotoxicity	290.50	14.58	245	121260	10740	42489090
Mucosal inflammation	290.47	14.58	512	120993	48862	42450968
Gastrointestinal toxicity	277.53	14.58	161	121344	3818	42496012
Cardiotoxicity	261.05	14.58	196	121309	7249	42492581
Headache	259.57	14.58	183	121322	239186	42260644
Completed suicide	258.75	14.58	3	121502	96462	42403368
Enteritis	257.16	14.58	227	121278	10589	42489241
Stomatitis	250.90	14.58	486	121019	49843	42449987
Flushing	244.15	14.58	404	121101	36624	42463206
Drug interaction	240.67	14.58	244	121261	266755	42233075
Gastrointestinal perforation	234.64	14.58	151	121354	4335	42495495
Fall	231.77	14.58	197	121308	234323	42265507
Decreased appetite	227.23	14.58	1120	120385	192017	42307813
Metastases to lung	221.59	14.58	214	121291	11210	42488620
Type I hypersensitivity	207.28	14.58	108	121397	2058	42497772
Malignant neoplasm progression	206.42	14.58	729	120776	107671	42392159
Laryngospasm	198.51	14.58	102	121403	1886	42497944
Enterocolitis	196.37	14.58	188	121317	9741	42490089
Overdose	194.53	14.58	33	121472	105231	42394599
Carcinoembryonic antigen increased	194.51	14.58	79	121426	819	42499011
Metastases to peritoneum	189.36	14.58	106	121399	2343	42497487
Neoplasm progression	185.26	14.58	312	121193	28688	42471142
Bone marrow failure	175.29	14.58	328	121177	32765	42467065
Tumour perforation	174.83	14.58	63	121442	456	42499374
Hypomagnesaemia	172.11	14.58	299	121206	28189	42471641
Feeling hot	170.87	14.58	268	121237	23214	42476616
Pneumonia	170.35	14.58	625	120880	421524	42078306
Drug ineffective	169.08	14.58	1080	120425	629117	41870713
Focal nodular hyperplasia	163.40	14.58	46	121459	126	42499704
Dysaesthesia pharynx	163.33	14.58	38	121467	29	42499801
Hospitalisation	160.02	14.58	14	121491	74316	42425514
Intentional product misuse	153.77	14.58	5	121500	61895	42437935
Leukopenia	151.17	14.58	513	120992	74233	42425597
Oxygen saturation decreased	149.80	14.58	465	121040	64222	42435608
Pyrexia	147.64	14.58	1743	119762	392299	42107531
Type II hypersensitivity	145.56	14.58	35	121470	36	42499794
Ascites	143.07	14.58	420	121085	56258	42443572
Abdominal pain	142.43	14.58	980	120525	189491	42310339
Hyperammonaemia	140.73	14.58	141	121364	7725	42492105
Stomal varices	140.38	14.58	39	121466	100	42499730
Injection site pain	139.00	14.58	6	121499	57792	42442038
Depression	138.89	14.58	72	121433	111291	42388539
Infusion related reaction	138.85	14.58	435	121070	60371	42439459
Bronchospasm	138.14	14.58	177	121328	12708	42487122
Anastomotic leak	137.10	14.58	59	121446	715	42499115
Hyperammonaemic encephalopathy	134.85	14.58	89	121416	2669	42497161
Inappropriate schedule of product administration	133.64	14.58	53	121452	95849	42403981
Weight increased	132.92	14.58	71	121434	107912	42391918
Cardiac failure congestive	131.87	14.58	40	121465	85562	42414268
Anxiety	131.83	14.58	88	121417	118472	42381358
Joint swelling	130.91	14.58	19	121486	68003	42431827
Neutrophil count decreased	130.65	14.58	438	121067	62977	42436853
Tumour lysis syndrome	129.96	14.58	230	121275	22001	42477829
Asthma	128.19	14.58	14	121491	62300	42437530
Evans syndrome	125.62	14.58	47	121458	383	42499447
Psoriasis	124.14	14.58	3	121502	48601	42451229
Anaphylactic shock	123.16	14.58	232	121273	23285	42476545
Myalgia	121.48	14.58	61	121444	96019	42403811
Proteinuria	120.70	14.58	227	121278	22756	42477074
Gastrointestinal anastomotic leak	120.56	14.58	50	121455	549	42499281
Somnolence	120.16	14.58	135	121370	140970	42358860
Pneumatosis intestinalis	119.52	14.58	103	121402	4649	42495181
Insomnia	119.52	14.58	97	121408	118156	42381674
Peripheral swelling	117.64	14.58	55	121450	90215	42409615
Non-cirrhotic portal hypertension	113.71	14.58	43	121462	362	42499468
Diffuse large B-cell lymphoma recurrent	113.06	14.58	101	121404	4785	42495045
Incorrect dose administered	108.71	14.58	12	121493	52962	42446868
Skin reaction	107.25	14.58	116	121389	6951	42492879
Intestinal obstruction	106.80	14.58	238	121267	26920	42472910
Rhabdomyolysis	105.64	14.58	45	121460	77974	42421856
Influenza	105.36	14.58	24	121481	62151	42437679
Condition aggravated	104.93	14.58	386	121119	260368	42239462
Colorectal cancer metastatic	103.81	14.58	52	121453	909	42498921
Aggression	101.70	14.58	6	121499	44157	42455673
Hyperhidrosis	101.30	14.58	518	120987	89994	42409836
Rheumatoid arthritis	100.11	14.58	5	121500	42435	42457395
Hallucination	99.87	14.58	21	121484	57486	42442344
Suicidal ideation	98.60	14.58	11	121494	48150	42451680
Death	97.62	14.58	867	120638	470318	42029512
Intravascular haemolysis	97.08	14.58	42	121463	516	42499314
Nasopharyngitis	96.55	14.58	60	121445	83936	42415894
Varices oesophageal	94.66	14.58	87	121418	4278	42495552
Toxic leukoencephalopathy	92.52	14.58	44	121461	683	42499147
Rash pustular	90.81	14.58	100	121405	6115	42493715
Arthritis	90.31	14.58	8	121497	42057	42457773
Pain	89.83	14.58	376	121129	244472	42255358
Acute coronary syndrome	87.14	14.58	154	121351	14711	42485119
Immune thrombocytopenia	85.76	14.58	131	121374	11085	42488745
Hypoalbuminaemia	85.49	14.58	157	121348	15453	42484377
Neutropenic colitis	85.29	14.58	83	121422	4387	42495443
Anaphylactic reaction	85.16	14.58	292	121213	42451	42457379
Contusion	84.92	14.58	10	121495	41975	42457855
Dehydration	84.65	14.58	692	120813	141075	42358755
Dihydropyrimidine dehydrogenase deficiency	83.68	14.58	25	121480	90	42499740
Confusional state	82.86	14.58	226	121279	167371	42332459
Musculoskeletal stiffness	81.98	14.58	31	121474	57734	42442096
Memory impairment	81.92	14.58	21	121484	50201	42449629
Anastomotic complication	81.71	14.58	35	121470	419	42499411
Foetal exposure during pregnancy	80.68	14.58	18	121487	47293	42452537
Ileus	80.10	14.58	172	121333	18967	42480863
Laryngeal discomfort	79.65	14.58	29	121476	217	42499613
Chronic obstructive pulmonary disease	78.37	14.58	41	121464	63073	42436757
Tumour necrosis	77.84	14.58	52	121453	1592	42498238
Pain in extremity	76.77	14.58	200	121305	150404	42349426
Blood glucose increased	76.26	14.58	59	121446	73640	42426190
Peritonitis	74.05	14.58	164	121341	18469	42481361
Hepatic atrophy	73.26	14.58	26	121479	179	42499651
Extravasation	73.03	14.58	58	121447	2332	42497498
Hiccups	72.52	14.58	127	121378	12044	42487786
Electrocardiogram ST segment elevation	72.35	14.58	87	121418	5852	42493978
Rectal perforation	72.06	14.58	34	121471	518	42499312
Feeling abnormal	72.04	14.58	56	121449	69730	42430100
Dizziness	71.68	14.58	417	121088	248837	42250993
Metastases to lymph nodes	71.66	14.58	87	121418	5911	42493919
Splenomegaly	71.11	14.58	153	121352	16894	42482936
Laryngeal oedema	70.14	14.58	71	121434	3937	42495893
Drug dependence	70.01	14.58	3	121502	29091	42470739
Temperature intolerance	69.88	14.58	77	121428	4711	42495119
Intestinal perforation	69.43	14.58	117	121388	10757	42489073
Therapeutic product effect decreased	68.59	14.58	14	121491	39136	42460694
Acute promyelocytic leukaemia	68.43	14.58	36	121469	700	42499130
Arthropathy	68.21	14.58	4	121501	29593	42470237
Vascular pain	67.88	14.58	25	121480	194	42499636
Sinusitis	67.74	14.58	25	121480	47267	42452563
Myocardial infarction	67.63	14.58	159	121346	123850	42375980
Large intestine perforation	66.82	14.58	107	121398	9429	42490401
Febrile neutropenia	66.80	14.58	816	120689	184887	42314943
Portal shunt	66.58	14.58	17	121488	27	42499803
Blood lactate dehydrogenase increased	66.47	14.58	194	121311	25887	42473943
Anaphylactoid reaction	65.74	14.58	60	121445	2923	42496907
Disseminated intravascular coagulation	64.70	14.58	186	121319	24608	42475222
Agitation	64.64	14.58	53	121452	64261	42435569
Colon cancer metastatic	64.34	14.58	47	121458	1665	42498165
Administration site extravasation	63.74	14.58	35	121470	744	42499086
Intestinal ischaemia	62.60	14.58	103	121402	9285	42490545
Asthenia	62.26	14.58	1135	120370	279658	42220172
Paraesthesia oral	61.86	14.58	75	121430	5088	42494742
Stoma site haemorrhage	61.83	14.58	39	121466	1080	42498750
Irritability	61.34	14.58	5	121500	28123	42471707
Loss of personal independence in daily activities	60.90	14.58	33	121472	49783	42450047
Hypokalaemia	60.73	14.58	381	121124	71340	42428490
Wrong technique in product usage process	60.29	14.58	23	121482	42612	42457218
Sedation	59.82	14.58	8	121497	30467	42469363
Azotaemia	59.58	14.58	79	121426	5865	42493965
Rectal cancer metastatic	59.50	14.58	24	121481	244	42499586
Dysaesthesia	59.44	14.58	53	121452	2504	42497326
Cytokine release syndrome	59.29	14.58	268	121237	44259	42455571
Drug reaction with eosinophilia and systemic symptoms	59	14.58	23	121482	42052	42457778
Colitis ulcerative	58.94	14.58	4	121501	26171	42473659
Throat tightness	58.28	14.58	101	121404	9498	42490332
Medication error	57.78	14.58	12	121493	33142	42466688
Off label use	57.74	14.58	2293	119212	636042	41863788
Blood cholesterol increased	57.63	14.58	5	121500	26736	42473094
Osteoarthritis	57.16	14.58	3	121502	24402	42475428
Fulminant type 1 diabetes mellitus	56.86	14.58	40	121465	1334	42498496
Electrocardiogram QT prolonged	56.83	14.58	33	121472	47912	42451918
Toxicity to various agents	56.82	14.58	401	121104	228735	42271095
Accidental overdose	56.67	14.58	7	121498	28323	42471507
Unevaluable event	56.57	14.58	14	121491	34274	42465556
Psychotic disorder	56.55	14.58	8	121497	29200	42470630
Hepatectomy	56.18	14.58	19	121486	111	42499719
Mucosal toxicity	56.13	14.58	24	121481	286	42499544
Fluid retention	56.03	14.58	11	121494	31608	42468222
Sleep disorder	55.74	14.58	34	121471	48061	42451769
Treatment noncompliance	55.52	14.58	19	121486	37653	42462177
Blood pressure fluctuation	55.44	14.58	6	121499	26902	42472928
Monocyte chemotactic protein-1 increased	55.33	14.58	25	121480	343	42499487
Alpha tumour necrosis factor increased	55.00	14.58	25	121480	348	42499482
Cellulitis	54.50	14.58	57	121448	61528	42438302
Nodular regenerative hyperplasia	54.12	14.58	35	121470	1013	42498817
Prostate cancer	53.95	14.58	30	121475	44613	42455217
Palmar erythema	53.85	14.58	28	121477	531	42499299
Subileus	53.79	14.58	58	121447	3463	42496367
Full blood count abnormal	53.77	14.58	10	121495	29866	42469964
Hyperthermia	53.77	14.58	114	121391	12460	42487370
Productive cough	53.70	14.58	41	121464	51526	42448304
Stress cardiomyopathy	53.68	14.58	52	121453	2733	42497097
Drug level increased	53.58	14.58	6	121499	26194	42473636
Hyperpyrexia	53.53	14.58	58	121447	3482	42496348
Upper respiratory tract infection	52.94	14.58	27	121478	42146	42457684
Dysphonia	52.90	14.58	190	121315	28260	42471570
Septic shock	52.80	14.58	444	121061	91228	42408602
Portal vein thrombosis	52.75	14.58	65	121440	4484	42495346
Infusion related hypersensitivity reaction	51.34	14.58	21	121484	222	42499608
Chronic kidney disease	51.22	14.58	36	121469	47205	42452625
Blood pressure systolic increased	51.12	14.58	9	121496	27959	42471871
Tumour marker increased	50.65	14.58	31	121474	813	42499017
Malignant ascites	50.37	14.58	28	121477	610	42499220
Bronchitis	49.83	14.58	37	121468	47164	42452666
Sleep apnoea syndrome	49.55	14.58	3	121502	21605	42478225
Coronary artery disease	49.50	14.58	48	121457	53672	42446158
Abnormal behaviour	49.48	14.58	8	121497	26443	42473387
Cholinergic syndrome	49.06	14.58	28	121477	643	42499187
Folliculitis	48.37	14.58	69	121436	5489	42494341
Papilloedema	48.23	14.58	53	121452	3233	42496597
Abdominal discomfort	48.18	14.58	88	121417	75167	42424663
Premature baby	48.12	14.58	5	121500	23148	42476682
Sensitisation	48.04	14.58	21	121484	265	42499565
Illness	47.86	14.58	7	121498	24923	42474907
Obstructive airways disorder	47.42	14.58	7	121498	24752	42475078
Diabetes mellitus	47.36	14.58	61	121444	60026	42439804
Swelling	47.23	14.58	52	121453	54833	42444997
Gastric stenosis	47.06	14.58	17	121488	124	42499706
Interleukin level increased	46.04	14.58	30	121475	880	42498950
Cardiac disorder	45.93	14.58	43	121462	48889	42450941
Recall phenomenon	45.83	14.58	26	121479	590	42499240
Cholangitis	45.57	14.58	97	121408	10630	42489200
Leukoencephalopathy	45.34	14.58	63	121442	4891	42494939
Mobility decreased	45.22	14.58	22	121483	35284	42464546
Lower respiratory tract infection	45.20	14.58	31	121474	41175	42458655
Portal venous gas	44.79	14.58	24	121481	485	42499345
Pulmonary ossification	44.76	14.58	14	121491	61	42499769
Eosinophilia	44.48	14.58	19	121486	32880	42466950
Contraindicated product administered	44.34	14.58	9	121496	25263	42474567
Stridor	44.21	14.58	47	121458	2761	42497069
Nephrolithiasis	44.15	14.58	25	121480	36805	42463025
Transdifferentiation of neoplasm	44.04	14.58	14	121491	65	42499765
Drug withdrawal syndrome	43.90	14.58	5	121500	21544	42478286
Liver injury	43.68	14.58	137	121368	19011	42480819
Pulmonary toxicity	43.60	14.58	84	121421	8571	42491259
Necrotising fasciitis	43.39	14.58	59	121446	4487	42495343
Gout	43.38	14.58	13	121492	28042	42471788
Hypervolaemia	43.24	14.58	7	121498	23118	42476712
Fingerprint loss	43.05	14.58	13	121492	49	42499781
Lung neoplasm malignant	42.89	14.58	3	121502	19144	42480686
Hand-foot-genital syndrome	42.15	14.58	11	121494	20	42499810
Gait disturbance	42.04	14.58	141	121364	97859	42401971
Metastasis	41.82	14.58	59	121446	4646	42495184
Splenorenal shunt	41.73	14.58	10	121495	10	42499820
Prinzmetal angina	41.61	14.58	33	121472	1324	42498506
Nasal congestion	41.57	14.58	16	121489	29485	42470345
Erectile dysfunction	41.43	14.58	10	121495	24903	42474927
Cyanosis	41.40	14.58	115	121390	14916	42484914
Adverse drug reaction	41.28	14.58	28	121477	37406	42462424
Oesophageal varices haemorrhage	40.96	14.58	51	121454	3556	42496274
Localised infection	40.83	14.58	5	121500	20368	42479462
Anastomotic fistula	40.80	14.58	14	121491	86	42499744
Embolism	40.46	14.58	82	121423	8681	42491149
Hyperbilirubinaemia	40.24	14.58	140	121365	20495	42479335
Cerebrovascular accident	40.18	14.58	142	121363	97018	42402812
International normalised ratio increased	39.96	14.58	47	121458	48121	42451709
Hypertransaminasaemia	39.85	14.58	84	121421	9143	42490687
Rectal tenesmus	39.74	14.58	30	121475	1118	42498712
Hepatocellular injury	39.73	14.58	153	121352	23525	42476305
Failure to anastomose	39.65	14.58	17	121488	204	42499626
Liver abscess	39.34	14.58	59	121446	4911	42494919
Herpes zoster	39.10	14.58	32	121473	38845	42460985
Circulatory collapse	39.06	14.58	152	121353	23484	42476346
Head injury	39.01	14.58	6	121499	20576	42479254
Carbohydrate antigen 19-9 increased	38.94	14.58	18	121487	261	42499569
Noninfective epididymitis	38.90	14.58	8	121497	0	42499830
Oxygen saturation normal	38.90	14.58	8	121497	0	42499830
Wound dehiscence	38.85	14.58	51	121454	3749	42496081
Wheezing	38.81	14.58	60	121445	54721	42445109
Thrombotic thrombocytopenic purpura	38.81	14.58	51	121454	3753	42496077
Pseudocirrhosis	38.75	14.58	10	121495	17	42499813
Cytomegalovirus infection	38.62	14.58	22	121483	32284	42467546
Adenocarcinoma metastatic	38.43	14.58	13	121492	76	42499754
Intentional product use issue	38.42	14.58	93	121412	71740	42428090
Seizure	38.27	14.58	195	121310	120366	42379464
Blood creatine phosphokinase increased	38.17	14.58	49	121456	48289	42451541
Basal cell carcinoma	38.05	14.58	9	121496	22724	42477106
Injection site erythema	38.02	14.58	6	121499	20189	42479641
General physical health deterioration	37.98	14.58	624	120881	150622	42349208
Influenza like illness	37.61	14.58	22	121483	31818	42468012
Enterovesical fistula	37.44	14.58	27	121478	937	42498893
Performance status decreased	37.32	14.58	56	121449	4664	42495166
Gastrointestinal obstruction	37.28	14.58	29	121476	1131	42498699
Gastric perforation	37.17	14.58	45	121460	3048	42496782
Blood pressure immeasurable	37.09	14.58	27	121478	951	42498879
Hypoaesthesia	36.92	14.58	338	121167	71125	42428705
Therapy interrupted	36.87	14.58	9	121496	22241	42477589
Amaurosis fugax	36.56	14.58	24	121481	713	42499117
Cataract	36.36	14.58	21	121484	30583	42469247
Hypertensive crisis	36.31	14.58	86	121419	10120	42489710
Small intestinal obstruction	36.13	14.58	119	121386	16942	42482888
Eczema	35.62	14.58	27	121478	34059	42465771
Pulmonary embolism	35.21	14.58	507	120998	119105	42380725
Chest discomfort	34.97	14.58	305	121200	63311	42436519
Pneumonitis	34.91	14.58	221	121284	41497	42458333
Oesophagitis	34.70	14.58	109	121396	15138	42484692
Large intestinal obstruction	34.47	14.58	33	121472	1709	42498121
Neutropenic sepsis	34.47	14.58	112	121393	15834	42483996
Tumour fistulisation	34.32	14.58	13	121492	110	42499720
Perforation	34.03	14.58	20	121485	486	42499344
Subdural haematoma	33.52	14.58	12	121493	23126	42476704
Peritoneal disorder	33.49	14.58	17	121488	306	42499524
Pulmonary oedema	33.47	14.58	63	121442	53209	42446621
Nicotinic acid deficiency	33.43	14.58	13	121492	119	42499711
Rib fracture	33.37	14.58	4	121501	16567	42483263
Pelvic abscess	33.31	14.58	26	121479	1019	42498811
Hypoglycaemia	33.20	14.58	76	121429	59778	42440052
Road traffic accident	33.08	14.58	7	121498	19086	42480744
Conjunctivitis	32.73	14.58	96	121409	12843	42486987
Feeling cold	32.57	14.58	96	121409	12877	42486953
Hepatic function abnormal	32.51	14.58	255	121250	51312	42448518
Oesophageal haemorrhage	32.26	14.58	29	121476	1385	42498445
Ventricular dysfunction	32.20	14.58	51	121454	4452	42495378
Emotional distress	32.13	14.58	4	121501	16089	42483741
Colitis	31.99	14.58	235	121270	46337	42453493
Haemolytic anaemia	31.66	14.58	91	121414	12036	42487794
Laboratory test abnormal	31.49	14.58	13	121492	22965	42476865
Incorrect route of product administration	31.35	14.58	15	121490	24290	42475540
Vascular injury	31.27	14.58	16	121489	293	42499537
Withdrawal syndrome	31.20	14.58	3	121502	14772	42485058
Product use issue	31.18	14.58	113	121392	76638	42423192
Poisoning	31	14.58	3	121502	14696	42485134
Product prescribing error	30.90	14.58	18	121487	26094	42473736
Tachycardia	30.75	14.58	431	121074	100656	42399174
Obesity	30.73	14.58	5	121500	16454	42483376
Organising pneumonia	30.72	14.58	67	121438	7465	42492365
Hypercreatinaemia	30.58	14.58	15	121490	250	42499580
Peripheral nerve injury	30.46	14.58	16	121489	310	42499520
Hepatic infarction	30.32	14.58	15	121490	255	42499575
UGT1A1 gene mutation	30.16	14.58	8	121497	16	42499814
Acute abdomen	30.15	14.58	33	121472	2004	42497826
COVID-19	30.13	14.58	200	121305	115748	42384082
Muscular weakness	30.06	14.58	129	121376	83369	42416461
Drug-induced liver injury	29.73	14.58	199	121306	38074	42461756
Blood alkaline phosphatase abnormal	29.66	14.58	20	121485	622	42499208
Haematoma	29.53	14.58	22	121483	28001	42471829
Gastrointestinal injury	29.47	14.58	25	121480	1104	42498726
Small intestinal perforation	29.34	14.58	39	121466	2902	42496928
Adenocarcinoma	29.27	14.58	33	121472	2071	42497759
Lymphangiosis carcinomatosa	29.22	14.58	24	121481	1013	42498817
Peripheral ischaemia	29.13	14.58	60	121445	6425	42493405
Renal disorder	28.96	14.58	24	121481	28956	42470874
Blood creatinine increased	28.96	14.58	189	121316	109814	42390016
Delirium	28.88	14.58	67	121438	52452	42447378
Heart rate decreased	28.87	14.58	37	121468	36495	42463335
Platelet count decreased	28.82	14.58	555	120950	138026	42361804
Liver function test abnormal	28.63	14.58	30	121475	32361	42467469
Rhinorrhoea	28.61	14.58	29	121476	31765	42468065
Aortic thrombosis	28.56	14.58	24	121481	1046	42498784
Labelled drug-drug interaction medication error	28.51	14.58	5	121500	15577	42484253
Immune-mediated enterocolitis	28.47	14.58	55	121450	5622	42494208
Necrotising oesophagitis	28.47	14.58	23	121482	948	42498882
Sciatic nerve palsy	28.45	14.58	9	121496	41	42499789
Haemorrhage intracranial	28.40	14.58	7	121498	17185	42482645
Nephrotic syndrome	28.39	14.58	71	121434	8647	42491183
Gastric varices	28.35	14.58	20	121485	670	42499160
Fixed eruption	28.35	14.58	35	121470	2419	42497411
Hypersomnia	28.31	14.58	4	121501	14614	42485216
Hyperlipidaemia	28.18	14.58	13	121492	21503	42478327
Encapsulating peritoneal sclerosis	28.12	14.58	19	121486	593	42499237
Acute respiratory distress syndrome	28.04	14.58	164	121341	29944	42469886
ECG signs of myocardial ischaemia	27.91	14.58	13	121492	192	42499638
Respiratory arrest	27.84	14.58	24	121481	28400	42471430
Angioedema	27.78	14.58	49	121456	42428	42457402
Onycholysis	27.77	14.58	23	121482	982	42498848
Cold sweat	27.64	14.58	83	121422	11247	42488583
Limb injury	27.50	14.58	4	121501	14301	42485529
Blood pressure increased	27.40	14.58	174	121331	101754	42398076
Blood triglycerides increased	27.19	14.58	6	121499	15890	42483940
Gastrointestinal necrosis	27.13	14.58	45	121460	4083	42495747
Gene mutation	26.61	14.58	29	121476	1752	42498078
Hepatic failure	26.60	14.58	193	121312	37907	42461923
Right ventricular ejection fraction decreased	26.41	14.58	9	121496	54	42499776
Brain teratoma	26.39	14.58	7	121498	14	42499816
Chronic myeloid leukaemia	26.34	14.58	34	121471	2458	42497372
Hyperkalaemia	26.17	14.58	129	121376	80329	42419501
Cough	26.16	14.58	354	121151	177749	42322081
Periportal sinus dilatation	26.09	14.58	12	121493	172	42499658
Haemoglobin abnormal	26.02	14.58	49	121456	4915	42494915
Oedema peripheral	26.01	14.58	255	121250	135821	42364009
Urinary tract infection	25.92	14.58	171	121334	99113	42400717
Haematemesis	25.90	14.58	161	121344	30038	42469792
Viral infection	25.90	14.58	16	121489	22467	42477363
Hepatic lesion	25.62	14.58	46	121459	4448	42495382
Rectosigmoid cancer	25.60	14.58	12	121493	180	42499650
Hypotension	25.59	14.58	936	120569	256695	42243135
Hallucination, visual	25.58	14.58	14	121491	21006	42478824
Insulin autoimmune syndrome	25.57	14.58	17	121488	516	42499314
Pulmonary hypertension	25.49	14.58	18	121487	23551	42476279
Metastases to muscle	25.41	14.58	13	121492	238	42499592
Respiratory depression	25.34	14.58	11	121494	18857	42480973
Diffuse alveolar damage	25.29	14.58	34	121471	2558	42497272
Blood phosphorus increased	25.28	14.58	3	121502	12522	42487308
Oesophageal stenosis	24.97	14.58	30	121475	2016	42497814
Skin laceration	24.68	14.58	5	121500	14053	42485777
Cerebral haemorrhage	24.55	14.58	46	121459	38920	42460910
Lewis-Sumner syndrome	24.53	14.58	9	121496	69	42499761
Alopecia	24.44	14.58	155	121350	29121	42470709
Intestinal dilatation	24.35	14.58	26	121479	1535	42498295
Central pain syndrome	24.21	14.58	11	121494	153	42499677
Anger	24.21	14.58	4	121501	13014	42486816
Device related thrombosis	24.20	14.58	25	121480	1420	42498410
Impaired work ability	24.15	14.58	3	121502	12088	42487742
Pulmonary fibrosis	23.99	14.58	144	121361	26537	42473293
Pulmonary artery thrombosis	23.99	14.58	20	121485	862	42498968
Abdominal sepsis	23.93	14.58	23	121482	1197	42498633
Trismus	23.93	14.58	35	121470	2849	42496981
Haemoglobinuria	23.91	14.58	18	121487	668	42499162
Diffuse large B-cell lymphoma refractory	23.91	14.58	29	121476	1968	42497862
Colorectal cancer recurrent	23.88	14.58	9	121496	75	42499755
Cytopenia	23.80	14.58	106	121399	17391	42482439
Visual impairment	23.70	14.58	55	121450	43058	42456772
Hypoaesthesia oral	23.64	14.58	46	121459	4727	42495103
Hypovolaemic shock	23.60	14.58	66	121439	8593	42491237
Oropharyngeal pain	23.56	14.58	54	121451	42456	42457374
Gastrointestinal stenosis	23.53	14.58	11	121494	164	42499666
Hyperaemia	23.07	14.58	25	121480	1501	42498329
Nodule	22.98	14.58	4	121501	12530	42487300
Tumour pseudoprogression	22.91	14.58	21	121484	1029	42498801
Ocular toxicity	22.84	14.58	14	121491	368	42499462
Peripheral sensorimotor neuropathy	22.74	14.58	28	121477	1930	42497900
Obstruction gastric	22.60	14.58	21	121484	1047	42498783
Eye pruritus	22.39	14.58	3	121502	11409	42488421
Anaphylactoid shock	22.37	14.58	15	121490	462	42499368
Gastric ischaemia	22.31	14.58	8	121497	57	42499773
Koebner phenomenon	22.19	14.58	8	121497	58	42499772
Oesophagobronchial fistula	22.18	14.58	11	121494	188	42499642
Tinnitus	22.16	14.58	30	121475	28908	42470922
Cheilitis	22.14	14.58	32	121473	2576	42497254
Diaphragmatic operation	22.11	14.58	7	121498	32	42499798
Bacterial colitis	22.07	14.58	8	121497	59	42499771
Vascular access complication	22.03	14.58	14	121491	393	42499437
Biliary fistula	22.01	14.58	9	121496	95	42499735
Mental disorder	21.95	14.58	12	121493	18017	42481813
Type III immune complex mediated reaction	21.92	14.58	16	121489	566	42499264
Coma	21.65	14.58	79	121426	53475	42446355
Blood potassium increased	21.62	14.58	13	121492	18523	42481307
Hyponatraemia	21.61	14.58	185	121320	101277	42398553
Arterial thrombosis	21.60	14.58	26	121479	1750	42498080
Immune-mediated hepatic disorder	21.57	14.58	31	121474	2483	42497347
Dystonia	21.53	14.58	5	121500	12785	42487045
Abdominal infection	21.52	14.58	31	121474	2488	42497342
Cholestasis	21.50	14.58	164	121341	32715	42467115
Balance disorder	21.50	14.58	67	121438	47578	42452252
Infusion site hypoaesthesia	21.39	14.58	5	121500	4	42499826
Cachexia	21.34	14.58	61	121444	8043	42491787
Amnesia	21.26	14.58	30	121475	28407	42471423
Jaundice	21.22	14.58	170	121335	34419	42465411
Oral dysaesthesia	21.22	14.58	9	121496	105	42499725
Astringent therapy	21.16	14.58	6	121499	17	42499813
Parasitic gastroenteritis	21.16	14.58	10	121495	153	42499677
Metastases to meninges	21.11	14.58	27	121478	1934	42497896
Disease recurrence	21.10	14.58	151	121354	29527	42470303
Cardiac ventricular disorder	21.05	14.58	12	121493	275	42499555
Dysentery	21.03	14.58	14	121491	426	42499404
Immune effector cell-associated neurotoxicity syndrome	20.94	14.58	67	121438	9394	42490436
Vena cava thrombosis	20.90	14.58	24	121481	1537	42498293
Perforation bile duct	20.89	14.58	8	121497	70	42499760
Dry eye	20.89	14.58	9	121496	15497	42484333
Anal sphincter atony	20.87	14.58	10	121495	158	42499672
Cardiac haemangioma benign	20.86	14.58	5	121500	5	42499825
Throat irritation	20.86	14.58	83	121422	12953	42486877
Rectal stenosis	20.77	14.58	11	121494	217	42499613
Restlessness	20.75	14.58	32	121473	29217	42470613
Hypersplenism	20.72	14.58	15	121490	524	42499306
Vocal cord paralysis	20.62	14.58	21	121484	1173	42498657
Platelet count increased	20.56	14.58	3	121502	10700	42489130
Heart rate irregular	20.55	14.58	10	121495	16040	42483790
Band sensation	20.49	14.58	9	121496	115	42499715
Perihepatic abscess	20.49	14.58	9	121496	115	42499715
Metastases to bone marrow	20.39	14.58	15	121490	537	42499293
Blood bilirubin increased	20.39	14.58	197	121308	42055	42457775
Dyspnoea exertional	20.25	14.58	74	121431	50074	42449756
Therapeutic response unexpected	20.08	14.58	4	121501	11377	42488453
Dyspnoea	20.04	14.58	1492	120013	441129	42058701
Disturbance in attention	19.94	14.58	34	121471	29832	42469998
Hyperfibrinolysis	19.79	14.58	6	121499	23	42499807
Hypercholesterolaemia	19.78	14.58	6	121499	12843	42486987
Adverse event	19.68	14.58	23	121482	23617	42476213
Acral peeling skin syndrome	19.63	14.58	7	121498	49	42499781
Cerebral vasoconstriction	19.61	14.58	11	121494	244	42499586
Device issue	19.58	14.58	7	121498	13502	42486328
Tooth disorder	19.55	14.58	5	121500	11974	42487856
Pruritus	19.50	14.58	689	120816	188082	42311748
Hip fracture	19.49	14.58	7	121498	13465	42486365
Appendicitis	19.47	14.58	18	121487	20595	42479235
Abdominal wall oedema	19.45	14.58	4	121501	0	42499830
Laryngoscopy	19.45	14.58	4	121501	0	42499830
Sinus bradycardia	19.41	14.58	9	121496	14844	42484986
Respiratory symptom	19.39	14.58	4	121501	11102	42488728
Full blood count decreased	19.37	14.58	18	121487	20542	42479288
Gastrointestinal mucosal necrosis	19.36	14.58	10	121495	187	42499643
Hypoacusis	19.30	14.58	15	121490	18687	42481143
Pneumatosis	19.28	14.58	15	121490	585	42499245
Monocytopenia	19.28	14.58	8	121497	88	42499742
Pulmonary arterial hypertension	19.23	14.58	3	121502	10184	42489646
Assisted suicide	19.19	14.58	5	121500	9	42499821
Portal vein dilatation	19.19	14.58	5	121500	9	42499821
Gastric dilatation	19.19	14.58	17	121488	796	42499034
Tumour haemorrhage	19.18	14.58	36	121469	3602	42496228
Diabetes mellitus inadequate control	19.09	14.58	10	121495	15380	42484450
Interventricular septum rupture	19.03	14.58	6	121499	27	42499803
Metastases to retroperitoneum	18.95	14.58	11	121494	261	42499569
Ischiorectal hernia	18.85	14.58	5	121500	10	42499820
Anorexia nervosa	18.85	14.58	6	121499	28	42499802
Muscle contractions involuntary	18.81	14.58	26	121479	2008	42497822
Ileal perforation	18.79	14.58	19	121486	1052	42498778
Dyskinesia	18.77	14.58	27	121478	25363	42474467
Gastrointestinal ulcer	18.76	14.58	25	121480	1865	42497965
Muscle spasms	18.72	14.58	156	121349	85888	42413942
Drug ineffective for unapproved indication	18.72	14.58	68	121437	46095	42453735
Vasculitis	18.67	14.58	15	121490	18379	42481451
Red blood cell sedimentation rate increased	18.56	14.58	3	121502	9921	42489909
Mental impairment	18.52	14.58	6	121499	12311	42487519
Malaise	18.50	14.58	760	120745	211396	42288434
Orthostatic hypotension	18.46	14.58	37	121468	30533	42469297
Cerebral amyloid angiopathy	18.44	14.58	11	121494	275	42499555
Lethargy	18.41	14.58	70	121435	46820	42453010
Peritoneal lesion	18.40	14.58	9	121496	149	42499681
Hepatic fibrosis	18.37	14.58	42	121463	4830	42495000
Neoplasm recurrence	18.31	14.58	30	121475	2694	42497136
Hypoxia	18.31	14.58	120	121385	69666	42430164
Back pain	18.29	14.58	289	121216	141487	42358343
Thrombophlebitis migrans	18.23	14.58	12	121493	358	42499472
Visual acuity reduced	18.21	14.58	14	121491	17536	42482294
Choking sensation	18.20	14.58	20	121485	1220	42498610
Aortitis	18.10	14.58	15	121490	641	42499189
Lip erythema	18.09	14.58	8	121497	104	42499726
Perineal disorder	18.01	14.58	7	121498	64	42499766
Blood glucose decreased	18.00	14.58	9	121496	14210	42485620
Appendicitis noninfective	17.95	14.58	5	121500	13	42499817
Eye irritation	17.95	14.58	5	121500	11313	42488517
Loss of consciousness	17.89	14.58	366	121139	91988	42407842
Product substitution issue	17.88	14.58	5	121500	11285	42488545
Immune-mediated lung disease	17.85	14.58	34	121471	3439	42496391
Abdominal pain lower	17.78	14.58	75	121430	12017	42487813
Restless legs syndrome	17.77	14.58	3	121502	9611	42490219
Akathisia	17.76	14.58	4	121501	10447	42489383
Bile duct necrosis	17.73	14.58	7	121498	67	42499763
Pachymeningitis	17.68	14.58	9	121496	163	42499667
Stomal hernia	17.66	14.58	12	121493	378	42499452
Oesophageal carcinoma recurrent	17.61	14.58	6	121499	36	42499794
Dysarthria	17.47	14.58	182	121323	39625	42460205
Vasospasm	17.43	14.58	14	121491	572	42499258
Intervertebral disc protrusion	17.35	14.58	5	121500	11067	42488763
Product administration error	17.35	14.58	16	121489	18327	42481503
Device related infection	17.32	14.58	108	121397	20171	42479659
Pelvic fluid collection	17.31	14.58	10	121495	235	42499595
Bradycardia	17.26	14.58	158	121347	85326	42414504
Mucocutaneous rash	17.20	14.58	6	121499	39	42499791
Biliary tract infection	17.15	14.58	16	121489	802	42499028
Eye pain	17.15	14.58	14	121491	17016	42482814
Disease susceptibility	17.11	14.58	7	121498	74	42499756
Osteomyelitis	17.11	14.58	16	121489	18207	42481623
Aplastic anaemia	16.98	14.58	7	121498	12377	42487453
Benign prostatic hyperplasia	16.97	14.58	21	121484	21031	42478799
Perineal ulceration	16.96	14.58	5	121500	17	42499813
Balanoposthitis	16.95	14.58	22	121483	1599	42498231
Eye disorder	16.86	14.58	6	121499	11606	42488224
Device malfunction	16.85	14.58	7	121498	12320	42487510
Acute myeloid leukaemia	16.85	14.58	115	121390	22141	42477689
Biliary abscess	16.82	14.58	6	121499	42	42499788
Catheter site extravasation	16.79	14.58	9	121496	182	42499648
Chemical peritonitis	16.77	14.58	8	121497	125	42499705
Neck pain	16.73	14.58	38	121467	29976	42469854
Bronchiectasis	16.71	14.58	16	121489	18003	42481827
Paravenous drug administration	16.69	14.58	4	121501	4	42499826
Intrahepatic portal hepatic venous fistula	16.69	14.58	4	121501	4	42499826
Blood uric acid increased	16.65	14.58	12	121493	15535	42484295
Glycosylated haemoglobin increased	16.63	14.58	8	121497	12916	42486914
B-cell small lymphocytic lymphoma	16.62	14.58	9	121496	186	42499644
Blood test abnormal	16.59	14.58	8	121497	12898	42486932
Low birth weight baby	16.55	14.58	4	121501	9951	42489879
Polyserositis	16.54	14.58	11	121494	334	42499496
Liver ablation	16.53	14.58	5	121500	19	42499811
Mood altered	16.51	14.58	5	121500	10713	42489117
Induration	16.46	14.58	18	121487	1092	42498738
Clonal haematopoiesis	16.44	14.58	9	121496	190	42499640
Immune-mediated myocarditis	16.42	14.58	25	121480	2109	42497721
Underdose	16.41	14.58	14	121491	16652	42483178
Tendonitis	16.40	14.58	4	121501	9890	42489940
Fistula of small intestine	16.39	14.58	14	121491	624	42499206
Miosis	16.29	14.58	9	121496	13437	42486393
Hypophagia	16.27	14.58	132	121373	26824	42473006
Transient ischaemic attack	16.26	14.58	46	121459	33693	42466137
Dysstasia	16.26	14.58	10	121495	14076	42485754
Skin disorder	16.24	14.58	93	121412	16851	42482979
Gait inability	16.18	14.58	25	121480	22808	42477022
Lip oedema	16.16	14.58	31	121474	3153	42496677
Nail disorder	16.15	14.58	26	121479	2301	42497529
Gastrointestinal stoma complication	16.12	14.58	21	121484	1532	42498298
Duodenal stenosis	16.12	14.58	11	121494	349	42499481
Pancreatitis	16.09	14.58	66	121439	43202	42456628
Intestinal transit time abnormal	15.95	14.58	5	121500	22	42499808
Granulocyte count decreased	15.94	14.58	21	121484	1549	42498281
Micturition urgency	15.88	14.58	7	121498	11891	42487939
Gynaecomastia	15.84	14.58	8	121497	12559	42487271
Electromyogram abnormal	15.82	14.58	6	121499	51	42499779
Traumatic ulcer	15.77	14.58	5	121500	23	42499807
Pulmonary congestion	15.75	14.58	13	121492	15717	42484113
Peritoneal haematoma	15.69	14.58	7	121498	93	42499737
Xerosis	15.62	14.58	16	121489	900	42498930
Hernia	15.61	14.58	6	121499	11067	42488763
Oropharyngeal spasm	15.60	14.58	9	121496	211	42499619
Haemoptysis	15.60	14.58	73	121432	46094	42453736
Venous thrombosis	15.45	14.58	35	121470	4000	42495830
Radiation interaction	15.43	14.58	5	121500	25	42499805
Thyroglobulin increased	15.43	14.58	5	121500	25	42499805
Acute motor-sensory axonal neuropathy	15.37	14.58	8	121497	152	42499678
Osteonecrosis of jaw	15.36	14.58	19	121486	19030	42480800
Myasthenia gravis	15.35	14.58	14	121491	16123	42483707
Neurosarcoidosis	15.34	14.58	9	121496	218	42499612
Peripheral motor neuropathy	15.31	14.58	25	121480	2239	42497591
Squamous cell carcinoma	15.29	14.58	9	121496	12973	42486857
Jaundice cholestatic	15.27	14.58	41	121464	5212	42494618
Vascular access site occlusion	15.23	14.58	6	121499	57	42499773
Blindness transient	15.20	14.58	28	121477	2761	42497069
Haematocrit decreased	15.11	14.58	50	121455	34858	42464972
Eczema impetiginous	15.11	14.58	5	121500	27	42499803
Eyelash thickening	15.08	14.58	4	121501	8	42499822
Pulmonary infarction	14.99	14.58	20	121485	1494	42498336
VIth nerve disorder	14.96	14.58	5	121500	28	42499802
Allodynia	14.95	14.58	17	121488	1077	42498753
Respiratory tract infection	14.94	14.58	33	121472	26289	42473541
Wound infection	14.88	14.58	55	121450	8291	42491539
Myoclonus	14.86	14.58	16	121489	17049	42482781
Dementia	14.86	14.58	15	121490	16465	42483365
C-reactive protein abnormal	14.86	14.58	4	121501	9257	42490573
Fistula	14.84	14.58	53	121452	7859	42491971
Surgery	14.81	14.58	17	121488	17599	42482231
Metastases to spleen	14.80	14.58	12	121493	497	42499333
Hepatic cancer recurrent	14.74	14.58	10	121495	314	42499516
Thrombotic microangiopathy	14.74	14.58	82	121423	14700	42485130
Hyperamylasaemia	14.69	14.58	13	121492	608	42499222
Eye infection gonococcal	14.67	14.58	5	121500	30	42499800
Muscle atrophy	14.62	14.58	3	121502	8358	42491472
Neuronal neuropathy	14.59	14.58	3	121502	0	42499830

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Neuropathy peripheral	4545.67	15.02	3174	187736	176103	110222286
Disease progression	3247.29	15.02	2959	187951	241075	110157314
Neutropenia	2266.30	15.02	3001	187909	371619	110026770
Neurotoxicity	1907.37	15.02	1080	189830	41127	110357262
Thrombocytopenia	1736.45	15.02	2546	188364	346339	110052050
Myelosuppression	1646.38	15.02	1338	189572	93002	110305387
Diarrhoea	1602.16	15.02	4943	185967	1134562	109263827
Arteriospasm coronary	1386.58	15.02	540	190370	8560	110389829
Palmar-plantar erythrodysaesthesia syndrome	1238.56	15.02	811	190099	40214	110358175
Laryngospasm	1166.46	15.02	399	190511	4269	110394120
Skin toxicity	1144.41	15.02	507	190403	11276	110387113
Dermatitis acneiform	1092.49	15.02	502	190408	12193	110386196
Polyneuropathy	973.96	15.02	636	190274	31376	110367013
Mucosal inflammation	802.51	15.02	908	190002	95233	110303156
Metastases to liver	793.99	15.02	583	190327	34803	110363586
Arthralgia	771.87	15.02	198	190712	779434	109618955
Peripheral sensory neuropathy	759.06	15.02	429	190481	16251	110382138
Nausea	737.64	15.02	4123	186787	1231567	109166822
Venoocclusive liver disease	718.84	15.02	401	190509	14806	110383583
Erythema	695.51	15.02	1546	189364	289901	110108488
Vomiting	676.67	15.02	3232	187678	907443	109490946
Chills	658.02	15.02	1180	189730	189400	110208989
Joint swelling	629.18	15.02	33	190877	442812	109955577
Headache	606.64	15.02	389	190521	881988	109516401
Paraesthesia	592.44	15.02	1406	189504	275115	110123274
Interstitial lung disease	584.43	15.02	941	189969	138393	110259996
Type I hypersensitivity	575.83	15.02	261	190649	6132	110392257
Therapy partial responder	549.73	15.02	479	190431	36582	110361807
Paronychia	547.86	15.02	301	190609	10780	110387609
Portal hypertension	541.64	15.02	275	190635	8362	110390027
Enteritis	528.08	15.02	358	190552	18798	110379591
Gastrointestinal toxicity	518.82	15.02	291	190619	10857	110387532
Stridor	514.10	15.02	247	190663	6648	110391741
Bronchospasm	499.99	15.02	416	190494	29823	110368566
Neoplasm progression	495.07	15.02	584	190326	64011	110334378
Bone marrow failure	493.89	15.02	553	190357	57295	110341094
Rheumatoid arthritis	480.79	15.02	7	190903	299606	110098783
Malignant neoplasm progression	479.43	15.02	981	189929	173586	110224803
Product dose omission issue	476.52	15.02	18	190892	321764	110076625
Haematotoxicity	472.11	15.02	347	190563	20735	110377654
Arthropathy	468.99	15.02	5	190905	287517	110110872
Dysaesthesia pharynx	468.96	15.02	106	190804	166	110398223
Cardiotoxicity	468.95	15.02	317	190593	16564	110381825
Non-cirrhotic portal hypertension	462.86	15.02	128	190782	613	110397776
Pain	449.09	15.02	596	190314	954359	109444030
Flushing	433.15	15.02	703	190207	104033	110294356
Weight increased	423.49	15.02	102	190808	419542	109978847
Nasopharyngitis	421.96	15.02	84	190826	394277	110004112
Systemic lupus erythematosus	421.60	15.02	3	190907	254335	110144054
Sinusitis	397.66	15.02	30	190880	296658	110101731
Febrile neutropenia	393.42	15.02	1322	189588	315445	110082944
Swelling	381.37	15.02	72	190838	350969	110047420
Neutrophil count decreased	379.56	15.02	719	190191	120222	110278167
Leukopenia	376.81	15.02	809	190101	147982	110250407
Peripheral swelling	376.08	15.02	115	190795	403919	109994470
Enterocolitis	367.00	15.02	286	190624	18663	110379726
Fall	366.03	15.02	303	190607	603179	109795210
Contraindicated product administered	363.75	15.02	15	190895	248252	110150137
Gastrointestinal perforation	361.63	15.02	200	190710	7256	110391133
Metastases to lung	358.05	15.02	306	190604	22757	110375632
Asthma	357.32	15.02	18	190892	250273	110148116
Ascites	342.44	15.02	592	190318	92216	110306173
Decreased appetite	333.24	15.02	1663	189247	474183	109924206
Glossodynia	330.04	15.02	12	190898	221992	110176397
Pemphigus	328.30	15.02	9	190901	214561	110183828
Depression	328.28	15.02	73	190837	317262	110081127
Throat tightness	327.53	15.02	344	190566	33145	110365244
Cytokine release syndrome	323.98	15.02	496	190414	69810	110328579
Therapeutic product effect decreased	320.96	15.02	27	190883	244289	110154100
Maternal exposure during pregnancy	306.92	15.02	39	190871	254844	110143545
Lower respiratory tract infection	303.15	15.02	33	190877	243073	110155316
Wound	299.64	15.02	29	190881	234408	110163981
Hypomagnesaemia	295.37	15.02	438	190472	59932	110338457
Osteoarthritis	294.05	15.02	4	190906	182619	110215770
Dysarthria	291.45	15.02	522	190388	83599	110314790
Contusion	290.16	15.02	32	190878	233329	110165060
Anaphylactic shock	285.94	15.02	397	190513	51149	110347240
Blood cholesterol increased	285.51	15.02	7	190903	184778	110213611
Helicobacter infection	284.48	15.02	6	190904	181871	110216518
Musculoskeletal stiffness	284.16	15.02	67	190843	279755	110118634
Drug abuse	280.93	15.02	5	190905	177406	110220983
Injury	280.68	15.02	5	190905	177260	110221129
Fibromyalgia	278.50	15.02	3	190907	170906	110227483
Hyperammonaemia	278.46	15.02	213	190697	13519	110384870
Abdominal discomfort	277.74	15.02	168	190742	393690	110004699
Hyperhidrosis	276.49	15.02	830	190080	186468	110211921
Metastases to peritoneum	273.50	15.02	151	190759	5459	110392930
Insomnia	271.23	15.02	142	190768	360448	110037941
Tumour perforation	267.38	15.02	81	190829	564	110397825
Duodenal ulcer perforation	259.38	15.02	11	190899	177689	110220700
Mobility decreased	259.26	15.02	48	190862	237374	110161015
Splenomegaly	256.42	15.02	261	190649	24237	110374152
Laryngeal oedema	255.43	15.02	177	190733	9630	110388759
Type 2 diabetes mellitus	245.95	15.02	15	190895	177217	110221172
Hyperammonaemic encephalopathy	242.45	15.02	138	190772	5296	110393093
Pericarditis	239.89	15.02	44	190866	219070	110179319
Arthritis	236.17	15.02	13	190897	167573	110230816
Nodular regenerative hyperplasia	235.10	15.02	93	190817	1538	110396851
Immune thrombocytopenia	234.26	15.02	239	190671	22255	110376134
Anastomotic leak	233.77	15.02	88	190822	1264	110397125
Focal nodular hyperplasia	231.84	15.02	79	190831	834	110397555
Oxygen saturation decreased	228.20	15.02	692	190218	156290	110242099
Hepatic enzyme increased	227.41	15.02	136	190774	320756	110077633
Abdominal pain	224.50	15.02	1585	189325	511404	109886985
Colorectal cancer metastatic	223.44	15.02	89	190821	1500	110396889
Type II hypersensitivity	223.30	15.02	49	190861	61	110398328
Injection site pain	222.17	15.02	24	190886	177898	110220491
Psoriasis	221.41	15.02	4	190906	139989	110258400
Migraine	219.94	15.02	21	190889	171631	110226758
Memory impairment	216.77	15.02	39	190871	196905	110201484
Sleep disorder	212.96	15.02	42	190868	198602	110199787
Tumour lysis syndrome	212.33	15.02	264	190646	30537	110367852
Overdose	207.78	15.02	72	190838	233722	110164667
Dyspnoea	206.63	15.02	2860	188050	1104012	109294377
Dysphonia	206.24	15.02	425	190485	75504	110322885
Pain in extremity	205.75	15.02	327	190583	486791	109911598
Carcinoembryonic antigen increased	203.99	15.02	99	190811	2725	110395664
C-reactive protein abnormal	203.92	15.02	4	190906	129691	110268698
Hypokalaemia	203.28	15.02	735	190175	181713	110216676
Evans syndrome	200.74	15.02	68	190842	704	110397685
Anxiety	199.54	15.02	181	190729	344897	110053492
Pyrexia	199.53	15.02	2397	188513	895868	109502521
Intestinal obstruction	196.90	15.02	340	190570	52887	110345502
Varices oesophageal	196.84	15.02	134	190776	7081	110391308
Proteinuria	196.67	15.02	291	190619	39727	110358662
Stomal varices	195.89	15.02	47	190863	109	110398280
Intentional product misuse	194.71	15.02	8	190902	132896	110265493
Platelet count decreased	193.72	15.02	850	190060	229593	110168796
Blister	193.65	15.02	75	190835	227301	110171088
Condition aggravated	193.10	15.02	638	190272	734198	109664191
Influenza	191.58	15.02	31	190879	169070	110229319
Drug ineffective	191.31	15.02	1694	189216	1518846	108879543
Drug intolerance	190.16	15.02	254	190656	406258	109992131
Hospitalisation	189.17	15.02	15	190895	142478	110255911
Exposure during pregnancy	188.99	15.02	31	190879	167393	110230996
Asthenia	188.80	15.02	1917	188993	687082	109711307
Anaphylactic reaction	184.40	15.02	523	190387	113777	110284612
Acute coronary syndrome	183.74	15.02	213	190697	22899	110375490
Feeling hot	179.51	15.02	449	190461	90657	110307732
Hyperthermia	179.18	15.02	202	190708	21070	110377319
Confusional state	178.40	15.02	336	190574	468344	109930045
Anaemia	178.04	15.02	1579	189331	545507	109852882
Gastrointestinal anastomotic leak	177.81	15.02	62	190848	705	110397684
Product use issue	176.05	15.02	167	190743	311528	110086861
Dysaesthesia	174.63	15.02	122	190788	6725	110391664
Hypoalbuminaemia	172.54	15.02	231	190679	28743	110369646
Bursitis	171.56	15.02	14	190896	129904	110268485
Impaired healing	170.66	15.02	63	190847	196654	110201735
Drug interaction	170.54	15.02	382	190528	499801	109898588
Bronchitis	168.74	15.02	33	190877	156999	110241390
Stress	162.68	15.02	4	190906	105344	110293045
Dehydration	162.62	15.02	929	189981	278582	110119807
Diffuse large B-cell lymphoma recurrent	162.44	15.02	113	190797	6186	110392203
Pneumonia	161.21	15.02	873	190037	875841	109522548
Suicide attempt	159.38	15.02	4	190906	103390	110294999
Obesity	159.06	15.02	9	190901	113342	110285047
Stress cardiomyopathy	157.47	15.02	164	190746	15642	110382747
Large intestine perforation	154.06	15.02	166	190744	16463	110381926
Inappropriate schedule of product administration	153.31	15.02	80	190830	203557	110194832
Discomfort	152.05	15.02	91	190819	214616	110183773
Lip dry	150.13	15.02	5	190905	100078	110298311
Road traffic accident	146.28	15.02	10	190900	107388	110291001
Rash pustular	144.04	15.02	142	190768	12687	110385702
Treatment failure	143.55	15.02	160	190750	277074	110121315
Neutropenic colitis	141.76	15.02	115	190795	7950	110390439
Gait inability	141.69	15.02	31	190879	136345	110262044
Ileus	140.40	15.02	216	190694	30513	110367876
Intestinal perforation	140.34	15.02	177	190733	20767	110377622
Septic shock	139.96	15.02	591	190319	156937	110241452
Laryngeal discomfort	139.15	15.02	52	190858	731	110397658
Pneumatosis intestinalis	138.19	15.02	116	190794	8413	110389976
Prescribed overdose	136.49	15.02	3	190907	87578	110310811
Off label use	135.62	15.02	3465	187445	1496720	108901669
Blood lactate dehydrogenase increased	134.59	15.02	260	190650	44074	110354315
Toxic leukoencephalopathy	133.04	15.02	62	190848	1555	110396834
Myalgia	132.89	15.02	113	190797	222268	110176121
Extravasation	132.21	15.02	90	190820	4755	110393634
Osteoporosis	132.00	15.02	4	190906	87148	110311241
Intentional product use issue	131.74	15.02	140	190770	247766	110150623
Injection site reaction	131.69	15.02	5	190905	89065	110309324
Disseminated intravascular coagulation	131.35	15.02	247	190663	41039	110357350
Hypercholesterolaemia	131.29	15.02	6	190904	90831	110307558
Pulmonary embolism	130.10	15.02	721	190189	213753	110184636
Cardiac failure congestive	129.89	15.02	49	190861	150951	110247438
Intravascular haemolysis	128.86	15.02	53	190857	974	110397415
Upper respiratory tract infection	128.30	15.02	34	190876	131294	110267095
Anaphylactoid reaction	127.79	15.02	101	190809	6725	110391664
Peritonitis	126.81	15.02	213	190697	32394	110365995
Administration site extravasation	126.05	15.02	61	190849	1668	110396721
Injection site erythema	124.75	15.02	10	190900	94166	110304223
Somnolence	123.28	15.02	202	190708	297247	110101142
Posterior reversible encephalopathy syndrome	122.23	15.02	214	190696	33647	110364742
Sciatica	121.87	15.02	10	190900	92389	110306000
Peripheral venous disease	120.14	15.02	6	190904	84111	110314278
Drug hypersensitivity	119.94	15.02	393	190517	453697	109944692
Hypertensive crisis	119.42	15.02	177	190733	24195	110374194
Infusion related hypersensitivity reaction	119.01	15.02	48	190862	837	110397552
Suicidal ideation	118.98	15.02	12	190898	93925	110304464
Band sensation	116.41	15.02	50	190860	1028	110397361
Dysphagia	115.19	15.02	548	190362	153052	110245337
Wheezing	114.73	15.02	164	190746	255066	110143323
Medication error	113.49	15.02	22	190888	105344	110293045
Folliculitis	113.26	15.02	75	190835	167578	110230811
Hiccups	113.18	15.02	125	190785	12744	110385645
Musculoskeletal pain	113.07	15.02	90	190820	182933	110215456
Skin reaction	113.00	15.02	160	190750	20984	110377405
Hepatic function abnormal	112.65	15.02	375	190535	88920	110309469
Fluid retention	112.09	15.02	15	190895	94292	110304097
Tachycardia	110.66	15.02	720	190190	225925	110172464
Alopecia	110.53	15.02	296	190614	364457	110033932
Speech disorder	110.49	15.02	293	190617	61276	110337113
Paraesthesia oral	110.31	15.02	204	190706	33467	110364922
Night sweats	109.49	15.02	47	190863	133936	110264453
Incorrect dose administered	108.80	15.02	23	190887	103618	110294771
Haemolytic anaemia	108.41	15.02	156	190754	20764	110377625
Chest discomfort	107.80	15.02	588	190322	173260	110225129
Hyperpyrexia	107.14	15.02	98	190812	7971	110390418
Tumour necrosis	106.36	15.02	61	190849	2375	110396014
Electrocardiogram ST segment elevation	105.85	15.02	103	190807	9057	110389332
Hyperbilirubinaemia	105.77	15.02	190	190720	30481	110367908
Tongue oedema	105.22	15.02	98	190812	8158	110390231
Azotaemia	104.72	15.02	107	190803	9978	110388411
Oesophageal varices haemorrhage	103.11	15.02	78	190832	4867	110393522
Loss of personal independence in daily activities	102.85	15.02	66	190844	149954	110248435
Dry mouth	102.82	15.02	116	190794	199832	110198557
Gait disturbance	102.66	15.02	203	190707	278005	110120384
Colitis	102.08	15.02	398	190512	101925	110296464
Dihydropyrimidine dehydrogenase deficiency	102.01	15.02	30	190880	186	110398203
Stoma site haemorrhage	101.91	15.02	59	190851	2339	110396050
Leukoencephalopathy	101.79	15.02	101	190809	9094	110389295
Mucosal toxicity	100.86	15.02	40	190870	666	110397723
Portal shunt	100.84	15.02	25	190885	70	110398319
Hepatic failure	99.80	15.02	303	190607	68436	110329953
Cyanosis	99.71	15.02	182	190728	29559	110368830
Fulminant type 1 diabetes mellitus	94.78	15.02	56	190854	2307	110396082
Intestinal ischaemia	93.30	15.02	127	190783	16052	110382337
Live birth	93.10	15.02	7	190903	69477	110328912
Inflammation	93.08	15.02	118	190792	193120	110205269
Colitis ulcerative	92.68	15.02	12	190898	77351	110321038
Grip strength decreased	92.37	15.02	14	190896	80160	110318229
Metastasis	91.87	15.02	91	190819	8176	110390213
Stomatitis	91.86	15.02	788	190122	269454	110128935
Colon cancer metastatic	91.84	15.02	56	190854	2445	110395944
Cholinergic syndrome	91.13	15.02	45	190865	1287	110397102
Illness	90.98	15.02	16	190894	82155	110316234
Sedation	90.64	15.02	8	190902	69675	110328714
Chronic obstructive pulmonary disease	89.65	15.02	38	190872	109120	110289269
Prescribed underdose	88.95	15.02	6	190904	65168	110333221
Hepatectomy	88.78	15.02	30	190880	308	110398081
Gastrooesophageal reflux disease	88.68	15.02	108	190802	179868	110218521
Metastases to lymph nodes	88.21	15.02	119	190791	14913	110383476
Cholangitis	87.87	15.02	124	190786	16211	110382178
Acute promyelocytic leukaemia	86.88	15.02	49	190861	1847	110396542
Blood pressure fluctuation	86.35	15.02	13	190897	74811	110323578
Subileus	85.12	15.02	78	190832	6359	110392030
Dizziness	85.02	15.02	783	190127	697410	109700979
Cytopenia	84.62	15.02	171	190739	29945	110368444
Adverse event	84.49	15.02	41	190869	108768	110289621
Gastric perforation	83.94	15.02	69	190841	4860	110393529
Rectal perforation	82.96	15.02	39	190871	998	110397391
Disease recurrence	82.74	15.02	262	190648	60522	110337867
Hypoaesthesia oral	82.62	15.02	123	190787	16879	110381510
Palmar erythema	82.41	15.02	51	190859	2287	110396102
Hallucination	82.21	15.02	36	190874	101396	110296993
Neuromyotonia	81.96	15.02	22	190888	92	110398297
Urticaria	81.37	15.02	280	190630	318577	110079812
Rhabdomyolysis	81.13	15.02	54	190856	120347	110278042
Hepatocellular injury	80.93	15.02	231	190679	50411	110347978
Anastomotic fistula	79.86	15.02	23	190887	131	110398258
Neck pain	79.29	15.02	58	190852	123072	110275317
White blood cell count decreased	78.00	15.02	669	190241	228721	110169668
Acute respiratory distress syndrome	77.69	15.02	235	190675	52963	110345426
Hypotension	77.65	15.02	1303	189607	522546	109875843
Injection site pruritus	75.35	15.02	3	190907	51255	110347134
Hypersensitivity	75.32	15.02	1045	189865	402953	109995436
Anastomotic complication	74.86	15.02	31	190879	580	110397809
Nasal congestion	74.85	15.02	38	190872	98244	110300145
Periportal sinus dilatation	74.72	15.02	22	190888	137	110398252
Feeling abnormal	74.58	15.02	123	190787	180588	110217801
Adverse drug reaction	74.34	15.02	45	190865	105514	110292875
Liver function test increased	74.05	15.02	30	190880	88518	110309871
Drug dependence	73.29	15.02	3	190907	50017	110348372
Tachypnoea	73.25	15.02	190	190720	39205	110359184
Hypovolaemic shock	73.02	15.02	107	190803	14476	110383913
Cold sweat	72.82	15.02	134	190776	21897	110376492
Vascular pain	72.53	15.02	37	190873	1136	110397253
Wrong technique in product usage process	72.39	15.02	30	190880	87318	110311071
Hepatic atrophy	71.80	15.02	28	190882	445	110397944
Pulmonary toxicity	71.78	15.02	118	190792	17628	110380761
Amnesia	71.39	15.02	47	190863	105361	110293028
Aggression	71.37	15.02	9	190901	59201	110339188
Portal vein thrombosis	69.89	15.02	73	190837	6985	110391404
Thrombotic microangiopathy	69.73	15.02	155	190755	28994	110369395
Choking sensation	69.13	15.02	59	190851	4377	110394012
Ocular toxicity	67.94	15.02	37	190873	1301	110397088
Temperature intolerance	67.90	15.02	101	190809	13849	110384540
Sensation of foreign body	67.62	15.02	76	190834	7899	110390490
Xeroderma	67.62	15.02	29	190881	594	110397795
Monocyte chemotactic protein-1 increased	67.45	15.02	25	190885	343	110398046
Herpes zoster	67.29	15.02	53	190857	108326	110290063
Drug reaction with eosinophilia and systemic symptoms	66.74	15.02	29	190881	82066	110316323
Psychotic disorder	65.84	15.02	6	190904	50931	110347458
Metastases to meninges	65.60	15.02	61	190849	5067	110393322
Ill-defined disorder	65.43	15.02	106	190804	156747	110241642
Blood pressure systolic increased	64.85	15.02	31	190879	82960	110315429
Productive cough	64.76	15.02	61	190849	114244	110284145
Alpha tumour necrosis factor increased	64.70	15.02	25	190885	387	110398002
Oedema	64.62	15.02	169	190741	209807	110188582
Rectal cancer metastatic	64.29	15.02	27	190883	524	110397865
Steatohepatitis	63.77	15.02	35	190875	1250	110397139
Sepsis	63.55	15.02	853	190057	326493	110071896
Immune effector cell-associated neurotoxicity syndrome	63.48	15.02	101	190809	14681	110383708
Embolism	62.79	15.02	106	190804	16183	110382206
Liver abscess	62.65	15.02	72	190838	7667	110390722
Cough	62.23	15.02	504	190406	461137	109937252
Nicotinic acid deficiency	62.20	15.02	21	190889	215	110398174
Hypertransaminasaemia	61.46	15.02	132	190778	24123	110374266
Underdose	61.04	15.02	17	190893	63537	110334852
Laryngeal dyspnoea	60.93	15.02	23	190887	333	110398056
Respiratory distress	60.82	15.02	258	190652	68616	110329773
Chemical peritonitis	60.64	15.02	22	190888	283	110398106
Blood glucose increased	60.64	15.02	84	190826	132412	110265977
Influenza like illness	60.45	15.02	39	190871	88373	110310016
Rhinorrhoea	60.29	15.02	53	190857	102613	110295776
Performance status decreased	59.49	15.02	68	190842	7198	110391191
Cellulitis	58.57	15.02	79	190831	125937	110272452
Drug level increased	58.13	15.02	7	190903	47712	110350677
Lupus-like syndrome	57.96	15.02	3	190907	40789	110357600
Trismus	57.89	15.02	64	190846	6532	110391857
Back injury	57.63	15.02	7	190903	47392	110350997
Sleep apnoea syndrome	57.39	15.02	3	190907	40444	110357945
Onychomadesis	57.39	15.02	6	190904	45657	110352732
Large intestinal obstruction	56.90	15.02	50	190860	3858	110394531
Prinzmetal angina	56.86	15.02	40	190870	2229	110396160
Pneumonitis	56.59	15.02	272	190638	76259	110322130
Cholestasis	56.44	15.02	241	190669	64277	110334112
Treatment noncompliance	55.91	15.02	28	190882	72962	110325427
Gastric stenosis	55.89	15.02	19	190891	199	110398190
Recall phenomenon	55.77	15.02	33	190877	1363	110397026
Malignant ascites	55.47	15.02	33	190877	1377	110397012
Portal venous gas	55.24	15.02	24	190886	508	110397881
Cold dysaesthesia	55.11	15.02	12	190898	14	110398375
Haematemesis	55.00	15.02	225	190685	58883	110339506
Encapsulating peritoneal sclerosis	54.88	15.02	28	190882	860	110397529
Tumour fistulisation	54.85	15.02	17	190893	129	110398260
Metastases to ovary	54.84	15.02	22	190888	378	110398011
Pancytopenia	54.67	15.02	578	190332	209035	110189354
Trichomegaly	54.51	15.02	17	190893	132	110398257
Breast cancer	54.25	15.02	3	190907	38539	110359850
Neutropenic sepsis	53.82	15.02	145	190765	30601	110367788
Oropharyngeal discomfort	53.49	15.02	77	190833	10250	110388139
Acute myeloid leukaemia	53.45	15.02	166	190744	37944	110360445
ECG signs of myocardial ischaemia	53.40	15.02	22	190888	406	110397983
Viral infection	53.35	15.02	13	190897	53126	110345263
Vocal cord paralysis	53.12	15.02	43	190867	2963	110395426
Diffuse large B-cell lymphoma refractory	53.09	15.02	40	190870	2481	110395908
Organising pneumonia	52.68	15.02	91	190819	14152	110384237
Dysgeusia	51.93	15.02	249	190661	69736	110328653
Papilloedema	51.85	15.02	64	190846	7345	110391044
Pulmonary ossification	51.70	15.02	14	190896	61	110398328
Immune-mediated enterocolitis	51.39	15.02	75	190835	10110	110388279
Dyspepsia	51.23	15.02	164	190746	190801	110207588
Interleukin level increased	51.23	15.02	33	190877	1588	110396801
Peripheral motor neuropathy	51.11	15.02	48	190862	4038	110394351
Urinary tract infection	50.75	15.02	342	190568	325940	110072449
Heart rate decreased	50.71	15.02	41	190869	82715	110315674
Necrotising fasciitis	50.61	15.02	64	190846	7527	110390862
Loss of consciousness	50.58	15.02	540	190370	195766	110202623
Basal cell carcinoma	49.71	15.02	9	190901	45261	110353128
Frequent bowel movements	49.48	15.02	31	190879	71359	110327030
Hepatic lesion	49.47	15.02	67	190843	8426	110389963
Vasospasm	49.23	15.02	32	190878	1564	110396825
Oesophagitis	48.84	15.02	134	190776	28581	110369808
Pharyngeal paraesthesia	48.75	15.02	47	190863	4085	110394304
Gastrointestinal injury	48.74	15.02	34	190876	1869	110396520
Metastases to bone marrow	48.62	15.02	27	190883	987	110397402
Wound infection	48.45	15.02	57	190853	96408	110301981
Granulocyte count decreased	48.40	15.02	46	190864	3928	110394461
Oxygen saturation normal	48.27	15.02	9	190901	0	110398389
Pseudocirrhosis	48.19	15.02	26	190884	897	110397492
Ear pain	47.93	15.02	16	190894	53210	110345179
Eczema	47.93	15.02	33	190877	72260	110326129
Carbohydrate antigen 19-9 increased	47.87	15.02	22	190888	534	110397855
Eosinophilia	47.84	15.02	20	190890	57916	110340473
Drug withdrawal syndrome	47.82	15.02	5	190905	38049	110360340
General physical health deterioration	47.81	15.02	1014	189896	424281	109974108
Product quality issue	47.73	15.02	38	190872	77261	110321128
Splenorenal shunt	47.64	15.02	11	190899	20	110398369
Hand-foot-genital syndrome	47.64	15.02	11	190899	20	110398369
Metastases to spleen	47.52	15.02	25	190885	819	110397570
Abdominal abscess	47.51	15.02	67	190843	8752	110389637
International normalised ratio increased	47.19	15.02	48	190862	86724	110311665
Infection	47.16	15.02	399	190511	361801	110036588
Hypophagia	47.14	15.02	198	190712	52428	110345961
Enterocutaneous fistula	47.02	15.02	36	190874	2287	110396102
Incorrect route of product administration	46.97	15.02	26	190884	64035	110334354
Emotional distress	46.97	15.02	10	190900	44837	110353552
Enterovesical fistula	46.96	15.02	30	190880	1423	110396966
Nephrolithiasis	46.94	15.02	28	190882	66184	110332205
Aortic thrombosis	46.77	15.02	35	190875	2148	110396241
Feeling cold	46.71	15.02	147	190763	33840	110364549
Therapy interrupted	46.61	15.02	14	190896	49808	110348581
Gastric varices	46.57	15.02	25	190885	854	110397535
Thrombocytopenic purpura	46.50	15.02	40	190870	2999	110395390
Failure to anastomose	46.42	15.02	17	190893	225	110398164
Congestive cardiomyopathy	46.38	15.02	86	190824	14133	110384256
Transdifferentiation of neoplasm	46.27	15.02	14	190896	97	110398292
Hydronephrosis	46.22	15.02	107	190803	20558	110377831
Onychomycosis	46.09	15.02	6	190904	38525	110359864
Gastrointestinal obstruction	45.97	15.02	35	190875	2205	110396184
Jaundice	45.59	15.02	213	190697	59023	110339366
Peripheral nerve injury	45.50	15.02	27	190883	1121	110397268
Injection site haemorrhage	45.19	15.02	3	190907	33025	110365364
Wound dehiscence	45.15	15.02	62	190848	7900	110390489
Acute motor axonal neuropathy	45.11	15.02	15	190895	146	110398243
Dry eye	44.89	15.02	20	190890	55773	110342616
Adenocarcinoma metastatic	44.67	15.02	19	190891	381	110398008
Biliary tract infection	44.62	15.02	31	190879	1693	110396696
Abortion spontaneous	44.41	15.02	4	190906	34278	110364111
Thrombotic thrombocytopenic purpura	44.35	15.02	58	190852	7053	110391336
Necrotising oesophagitis	44.32	15.02	30	190880	1570	110396819
Accidental overdose	44.26	15.02	17	190893	51817	110346572
Head injury	44.22	15.02	10	190900	43007	110355382
Oesophageal haemorrhage	44.13	15.02	32	190878	1871	110396518
Peripheral ischaemia	44.01	15.02	73	190837	10985	110387404
Hypercreatinaemia	43.78	15.02	19	190891	401	110397988
Full blood count abnormal	43.70	15.02	21	190889	56031	110342358
Gastric varices haemorrhage	43.68	15.02	20	190890	481	110397908
Rib fracture	43.59	15.02	4	190906	33766	110364623
Dysentery	43.55	15.02	28	190882	1343	110397046
Rectal tenesmus	43.49	15.02	34	190876	2228	110396161
Serotonin syndrome	43.38	15.02	24	190886	59129	110339260
Fingerprint loss	43.35	15.02	13	190897	87	110398302
Acute abdomen	43.03	15.02	40	190870	3321	110395068
Small intestinal perforation	42.86	15.02	45	190865	4331	110394058
Retching	42.79	15.02	110	190800	22572	110375817
Gastrointestinal necrosis	42.72	15.02	55	190855	6585	110391804
Diabetes mellitus	42.54	15.02	66	190844	99315	110299074
Withdrawal syndrome	42.50	15.02	3	190907	31377	110367012
Electrocardiogram QT prolonged	42.36	15.02	77	190833	108883	110289506
Gene mutation	42.35	15.02	40	190870	3389	110395000
Fixed eruption	42.31	15.02	44	190866	4188	110394201
Small intestinal obstruction	42.15	15.02	137	190773	32076	110366313
Blepharospasm	42.08	15.02	21	190889	54830	110343559
Cataract	42.07	15.02	45	190865	79440	110318949
Irritability	41.97	15.02	15	190895	47794	110350595
Formication	41.49	15.02	50	190860	5598	110392791
Haemoglobinuria	41.09	15.02	23	190887	854	110397535
Myocardial infarction	41.07	15.02	181	190729	191902	110206487
Autoimmune haemolytic anaemia	41.05	15.02	69	190841	10498	110387891
Perforation	40.98	15.02	30	190880	1780	110396609
C-reactive protein increased	40.98	15.02	215	190695	217704	110180685
Hypervolaemia	40.96	15.02	17	190893	49443	110348946
Unevaluable event	40.66	15.02	26	190884	59201	110339188
Ileal perforation	40.58	15.02	27	190883	1373	110397016
Delirium	40.53	15.02	110	190800	134915	110263474
Device related thrombosis	40.13	15.02	39	190871	3423	110394966
Immune-mediated myocarditis	39.79	15.02	39	190871	3459	110394930
Lung disorder	39.51	15.02	168	190742	179879	110218510
Skin fissures	39.50	15.02	112	190798	24346	110374043
Tumour haemorrhage	39.46	15.02	47	190863	5198	110393191
Suffocation feeling	39.27	15.02	31	190879	2060	110396329
Laboratory test abnormal	38.40	15.02	14	190896	44065	110354324
Lip oedema	38.39	15.02	56	190854	7544	110390845
Abnormal behaviour	38.32	15.02	10	190900	39029	110359360
Nephrotic syndrome	38.22	15.02	78	190832	13753	110384636
Aortitis	38.12	15.02	30	190880	1985	110396404
Tremor	37.99	15.02	524	190386	201708	110196681
Disability	37.91	15.02	4	190906	30219	110368170
Oropharyngeal pain	37.82	15.02	114	190796	135162	110263227
Laryngitis	37.75	15.02	13	190897	42398	110355991
Amaurosis fugax	37.68	15.02	32	190878	2358	110396031
Peripheral sensorimotor neuropathy	37.65	15.02	40	190870	3903	110394486
Cardiac disorder	37.32	15.02	46	190864	76234	110322155
Blood pressure immeasurable	37.30	15.02	32	190878	2391	110395998
Bronchostenosis	37.02	15.02	22	190888	916	110397473
Skin laceration	36.44	15.02	7	190903	33746	110364643
Immunodeficiency	36.17	15.02	11	190899	38827	110359562
Gastrointestinal stoma complication	36.17	15.02	36	190874	3253	110395136
Electrolyte imbalance	36.08	15.02	143	190767	36885	110361504
Abdominal sepsis	36.04	15.02	31	190879	2324	110396065
Hepatic cytolysis	35.99	15.02	189	190721	54864	110343525
Balance disorder	35.71	15.02	94	190816	116466	110281923
Femur fracture	35.69	15.02	16	190894	44453	110353936
Portal hypertensive gastropathy	35.22	15.02	28	190882	1880	110396509
Guillain-Barre syndrome	35.07	15.02	65	190845	10679	110387710
Portal vein dilatation	35.01	15.02	10	190900	55	110398334
Haemolysis	35	15.02	81	190829	15558	110382831
Adenocarcinoma	34.95	15.02	40	190870	4240	110394149
Abdominal infection	34.95	15.02	42	190868	4689	110393700
Hypertrichosis	34.78	15.02	27	190883	1751	110396638
Microangiopathic haemolytic anaemia	34.77	15.02	28	190882	1915	110396474
Neoplasm recurrence	34.71	15.02	44	190866	5188	110393201
Gout	34.71	15.02	10	190900	36556	110361833
Pulmonary arterial hypertension	34.65	15.02	7	190903	32561	110365828
Limb injury	34.44	15.02	11	190899	37625	110360764
Hallucination, auditory	34.41	15.02	3	190907	26394	110371995
Liver function test abnormal	34.35	15.02	41	190869	68909	110329480
Tongue disorder	34.16	15.02	76	190834	14222	110384167
Oral dysaesthesia	34.10	15.02	14	190896	256	110398133
Therapy non-responder	33.77	15.02	148	190762	157159	110241230
K-ras gene mutation	33.73	15.02	10	190900	64	110398325
Blood pressure diastolic decreased	33.72	15.02	10	190900	35875	110362514
Insulin autoimmune syndrome	33.52	15.02	19	190891	723	110397666
Panic attack	33.46	15.02	5	190905	28935	110369454
Obstructive airways disorder	33.44	15.02	19	190891	46130	110352259
UGT1A1 gene mutation	33.21	15.02	8	190902	19	110398370
Eyelid ptosis	33.16	15.02	72	190838	13255	110385134
Eye pain	33.03	15.02	23	190887	50076	110348313
Pulmonary artery thrombosis	32.81	15.02	25	190885	1577	110396812
Protein-losing gastroenteropathy	32.53	15.02	20	190890	886	110397503
Localised infection	32.25	15.02	17	190893	43031	110355358
Muscular weakness	32.20	15.02	274	190636	248194	110150195
Noninfective epididymitis	32.18	15.02	6	190904	0	110398389
Hypersomnia	32.09	15.02	5	190905	28056	110370333
Muscle contractions involuntary	32.09	15.02	39	190871	4405	110393984
Deep vein thrombosis	32.02	15.02	376	190534	139511	110258878
Adenocarcinoma of colon	31.96	15.02	46	190864	6122	110392267
Splenic artery thrombosis	31.80	15.02	10	190900	80	110398309
Metastases to central nervous system	31.64	15.02	99	190811	22718	110375671
Oedema peripheral	31.63	15.02	389	190521	328271	110070118
Haemolytic uraemic syndrome	31.62	15.02	41	190869	4944	110393445
Hepatic encephalopathy	31.57	15.02	114	190796	28142	110370247
Toxic erythema of chemotherapy	31.44	15.02	15	190895	397	110397992
Epistaxis	31.44	15.02	354	190556	130018	110268371
Heart rate irregular	31.40	15.02	10	190900	34264	110364125
Tendonitis	31.35	15.02	4	190906	26079	110372310
Immune-mediated lung disease	31.14	15.02	42	190868	5261	110393128
Haematoma	31.06	15.02	33	190877	58443	110339946
Multiple sclerosis	30.74	15.02	4	190906	25694	110372695
Ventricular fibrillation	30.66	15.02	147	190763	41166	110357223
Pulmonary sarcoidosis	30.58	15.02	25	190885	1747	110396642
Ventricular dysfunction	30.45	15.02	50	190860	7461	110390928
Hepatic fibrosis	30.44	15.02	52	190858	8014	110390375
Immune-mediated hepatic disorder	30.44	15.02	38	190872	4412	110393977
Fatigue	30.38	15.02	1754	189156	1214204	109184185
Post embolisation syndrome	30.38	15.02	10	190900	94	110398295
Coronary artery disease	30.31	15.02	48	190862	71642	110326747
Hypoglycaemia	30.24	15.02	101	190809	116003	110282386
Chemotherapy toxicity attenuation	30.22	15.02	7	190903	13	110398376
Tooth disorder	30.05	15.02	7	190903	29502	110368887
Rectal cancer recurrent	30.04	15.02	9	190901	60	110398329
Device issue	30.03	15.02	11	190899	34524	110363865
Diffuse alveolar damage	30.01	15.02	36	190874	4011	110394378
Acute myocardial infarction	29.86	15.02	247	190663	83530	110314859
Procedural pain	29.81	15.02	12	190898	35553	110362836
Right ventricular ejection fraction decreased	29.79	15.02	9	190901	62	110398327
Type III immune complex mediated reaction	29.78	15.02	20	190890	1033	110397356
Metastases to diaphragm	29.67	15.02	9	190901	63	110398326
Appendicitis noninfective	29.56	15.02	7	190903	15	110398374
Platelet count increased	29.43	15.02	5	190905	26329	110372060
Swelling face	29.40	15.02	73	190837	92248	110306141
Intervertebral disc protrusion	29.37	15.02	6	190904	27692	110370697
Balanoposthitis	29.35	15.02	22	190888	1354	110397035
Nail disorder	29.34	15.02	34	190876	57901	110340488
Metastases to muscle	29.33	15.02	14	190896	371	110398018
Phrenic nerve paralysis	29.16	15.02	16	190894	571	110397818
Infusion site hypoaesthesia	29.15	15.02	8	190902	37	110398352
Hypertriglyceridaemia	29.10	15.02	77	190833	16077	110382312
Peritoneal disorder	29.07	15.02	18	190892	808	110397581
Immune-mediated hepatitis	29.02	15.02	46	190864	6665	110391724
Asphyxia	28.98	15.02	71	190839	14144	110384245
Cachexia	28.71	15.02	67	190843	12938	110385451
Tumour ulceration	28.69	15.02	13	190897	305	110398084
Acute kidney injury	28.61	15.02	1356	189554	634074	109764315
Drug-induced liver injury	28.49	15.02	325	190585	119742	110278647
Nervousness	28.43	15.02	14	190896	36837	110361552
Anorectal varices haemorrhage	28.39	15.02	7	190903	19	110398370
Encephalopathy	28.37	15.02	238	190672	80817	110317572
Lewis-Sumner syndrome	28.30	15.02	9	190901	75	110398314
Duodenal ulcer	28.30	15.02	86	190824	19428	110378961
Diaphragmatic paralysis	28.29	15.02	21	190889	1273	110397116
Blood glucose decreased	28.11	15.02	8	190902	29480	110368909
Sciatic nerve palsy	28.09	15.02	9	190901	77	110398312
Tumour marker increased	28.09	15.02	39	190871	5021	110393368
Poor quality sleep	27.93	15.02	7	190903	28070	110370319
Iris cyst	27.88	15.02	7	190903	21	110398368
Skin disorder	27.83	15.02	147	190763	42766	110355623
Obstruction gastric	27.83	15.02	25	190885	1986	110396403
Hypersplenism	27.74	15.02	17	190893	749	110397640
Weight fluctuation	27.60	15.02	3	190907	22142	110376247
Cytomegalovirus infection	27.52	15.02	32	190878	54412	110343977
Mucosal disorder	27.50	15.02	36	190874	4381	110394008
Terminal ileitis	27.48	15.02	23	190887	1661	110396728
Colon cancer recurrent	27.47	15.02	10	190900	130	110398259
Pulmonary hypertension	27.33	15.02	33	190877	55187	110343202
Hypocalcaemia	27.33	15.02	200	190710	65166	110333223
Normal newborn	27.20	15.02	3	190907	21893	110376496
Cystitis	27.18	15.02	45	190865	65991	110332398
Medical device site extravasation	27.11	15.02	6	190904	8	110398381
Conjunctivitis	27.10	15.02	123	190787	33669	110364720
Hyperaemia	27.06	15.02	33	190877	3740	110394649
Larynx irritation	27.00	15.02	11	190899	197	110398192
Protein urine	26.95	15.02	22	190888	1534	110396855
Mixed adenoneuroendocrine carcinoma	26.95	15.02	7	190903	25	110398364
Product storage error	26.93	15.02	3	190907	21725	110376664
Chronic myeloid leukaemia	26.88	15.02	35	190875	4238	110394151
Anaphylactic transfusion reaction	26.82	15.02	5	190905	0	110398389
Restless legs syndrome	26.81	15.02	5	190905	24621	110373768
Product substitution issue	26.62	15.02	4	190906	23057	110375332
Biliary fistula	26.60	15.02	10	190900	143	110398246
Ileus paralytic	26.50	15.02	61	190849	11676	110386713
Left ventricular dysfunction	26.43	15.02	95	190815	23398	110374991
Hallucination, visual	26.36	15.02	18	190892	39587	110358802
Colorectal cancer recurrent	26.33	15.02	9	190901	96	110398293
Gastric ischaemia	26.25	15.02	8	190902	57	110398332
Premature delivery	26.23	15.02	10	190900	30622	110367767
Product prescribing error	26.13	15.02	30	190880	51301	110347088
Pharyngeal dyskinesia	26.13	15.02	8	190902	58	110398331
Ventricular hypokinesia	26.11	15.02	59	190851	11155	110387234
Factor VII deficiency	26.08	15.02	9	190901	99	110398290
Labelled drug-drug interaction medication error	26.05	15.02	9	190901	29293	110369096
Cardiogenic shock	26.05	15.02	179	190731	57159	110341230
Pneumatosis	25.91	15.02	18	190892	983	110397406
Bone marrow oedema syndrome	25.89	15.02	8	190902	60	110398329
Gallbladder disorder	25.83	15.02	3	190907	21026	110377363
Respiratory failure	25.66	15.02	518	190392	214814	110183575
Leukocytosis	25.62	15.02	170	190740	53658	110344731
Second primary malignancy	25.61	15.02	79	190831	17989	110380400
Diaphragmatic operation	25.58	15.02	7	190903	32	110398357
Pelvic abscess	25.54	15.02	27	190883	2619	110395770
Pallor	25.48	15.02	176	190734	56291	110342098
Extrapyramidal disorder	25.43	15.02	9	190901	28858	110369531
Hyperfibrinolysis	25.40	15.02	7	190903	33	110398356
Pelvic fluid collection	25.40	15.02	18	190892	1015	110397374
Arterial thrombosis	25.22	15.02	29	190881	3090	110395299
Injection site paraesthesia	25.18	15.02	16	190894	752	110397637
Tinnitus	25.16	15.02	41	190869	60499	110337890
Thrombophlebitis migrans	25.06	15.02	16	190894	758	110397631
Short-bowel syndrome	25.02	15.02	16	190894	760	110397629
Back pain	24.78	15.02	471	190439	370525	110027864
Toxic cardiomyopathy	24.78	15.02	16	190894	773	110397616
Cystitis radiation	24.72	15.02	11	190899	247	110398142
Heat stroke	24.72	15.02	23	190887	1912	110396477
Cardiomyopathy	24.67	15.02	119	190791	33406	110364983
Eye pruritus	24.47	15.02	13	190897	32762	110365627
Drug ineffective for unapproved indication	24.42	15.02	93	190817	102745	110295644
Onycholysis	24.29	15.02	27	190883	2772	110395617
Reactive capillary endothelial proliferation	24.28	15.02	7	190903	40	110398349
Retroperitoneal lymphadenopathy	24.24	15.02	20	190890	1416	110396973
Cutaneous lupus erythematosus	24.20	15.02	30	190880	3458	110394931
Shock	24.17	15.02	167	190743	53421	110344968
Koebner phenomenon	24.14	15.02	8	190902	77	110398312
Subacute cutaneous lupus erythematosus	24.08	15.02	36	190874	4958	110393431
Myelodysplastic syndrome	24.03	15.02	128	190782	37356	110361033
Gastroenteritis viral	23.88	15.02	12	190898	31214	110367175
Anaphylactoid shock	23.83	15.02	17	190893	969	110397420
Impaired work ability	23.69	15.02	8	190902	26411	110371978
Pigmentation disorder	23.57	15.02	44	190866	7267	110391122
Testicular disorder	23.56	15.02	12	190898	367	110398022
Chronic sinusitis	23.55	15.02	7	190903	25077	110373312
Perforation bile duct	23.51	15.02	8	190902	84	110398305
Rash maculo-papular	23.41	15.02	213	190697	74009	110324380
Retroperitoneal abscess	23.36	15.02	14	190896	592	110397797
Cardiac haemangioma benign	23.36	15.02	5	190905	5	110398384
Neutrophil count abnormal	23.34	15.02	36	190874	5096	110393293
Immune-mediated adverse reaction	23.26	15.02	21	190889	1679	110396710
Osteopenia	23.16	15.02	5	190905	22204	110376185
Immune-mediated cholangitis	23.13	15.02	16	190894	868	110397521
Product dose omission in error	23.12	15.02	6	190904	23506	110374883
Acral peeling skin syndrome	23.07	15.02	7	190903	49	110398340
Respiratory disorder	23.07	15.02	56	190854	71326	110327063
Gastrointestinal stenosis	22.84	15.02	12	190898	392	110397997
COVID-19	22.84	15.02	292	190618	244768	110153621
Respiratory arrest	22.83	15.02	41	190869	58258	110340131
Perineal disorder	22.83	15.02	7	190903	51	110398338
Spinal stenosis	22.71	15.02	3	190907	19053	110379336
Head discomfort	22.63	15.02	3	190907	18997	110379392
Pneumoperitoneum	22.56	15.02	31	190879	3953	110394436
Sputum discoloured	22.51	15.02	10	190900	27935	110370454
Gastrointestinal ulcer	22.41	15.02	32	190878	4228	110394161
Gastrointestinal mucosal necrosis	22.33	15.02	10	190900	228	110398161
Blood pressure diastolic increased	22.32	15.02	3	190907	18804	110379585
Blood potassium increased	22.27	15.02	15	190895	33234	110365155
Heart rate increased	22.22	15.02	151	190759	143683	110254706
Epstein-Barr virus infection	22.22	15.02	3	190907	18735	110379654
Abdominal wall oedema	22.18	15.02	6	190904	26	110398363
Immediate post-injection reaction	22.11	15.02	12	190898	419	110397970
Hepatic vein stenosis	22.05	15.02	7	190903	58	110398331
Parasitic gastroenteritis	21.98	15.02	10	190900	237	110398152
Blood bilirubin increased	21.95	15.02	214	190696	75758	110322631
Implant site dehiscence	21.90	15.02	9	190901	165	110398224
Musculoskeletal disorder	21.88	15.02	6	190904	22658	110375731
Sense of oppression	21.85	15.02	20	190890	1628	110396761
Astringent therapy	21.82	15.02	6	190904	28	110398361
Clonal haematopoiesis	21.80	15.02	9	190901	167	110398222
Hyperkalaemia	21.77	15.02	141	190769	135655	110262734
Perihepatic abscess	21.75	15.02	9	190901	168	110398221
Stomal hernia	21.69	15.02	13	190897	550	110397839
Epilepsy	21.67	15.02	94	190816	100115	110298274
Skin hyperpigmentation	21.66	15.02	47	190863	8649	110389740
Lymphangiosis carcinomatosa	21.64	15.02	24	190886	2458	110395931
Ankle fracture	21.63	15.02	4	190906	19815	110378574
Hyperlipasaemia	21.58	15.02	19	190891	1470	110396919
Catheter site extravasation	21.50	15.02	13	190897	559	110397830
Cardiac ventricular disorder	21.49	15.02	11	190899	340	110398049
Laryngoscopy	21.45	15.02	4	190906	0	110398389
Endothelial dysfunction	21.44	15.02	11	190899	342	110398047
Ischiorectal hernia	21.34	15.02	5	190905	10	110398379
Infusion related reaction	21.29	15.02	832	190078	380330	110018059
Vascular injury	21.22	15.02	17	190893	1154	110397235
Intervertebral disc degeneration	21.20	15.02	3	190907	18082	110380307
Surgery	21.15	15.02	24	190886	41259	110357130
Hernia	21.15	15.02	4	190906	19496	110378893
Toxic encephalopathy	21.08	15.02	66	190844	15148	110383241
Metastatic neoplasm	21.04	15.02	37	190873	5836	110392553
Eczema impetiginous	21.01	15.02	6	190904	33	110398356
Oesophagobronchial fistula	20.99	15.02	10	190900	264	110398125
Haemorrhage intracranial	20.89	15.02	12	190898	28957	110369432
Blood creatine phosphokinase increased	20.84	15.02	61	190849	73016	110325373
Device related infection	20.78	15.02	128	190782	39391	110358998
Aplastic anaemia	20.71	15.02	8	190902	24300	110374089
Orthostatic hypotension	20.61	15.02	53	190857	66196	110332193
Hyperamylasaemia	20.60	15.02	17	190893	1204	110397185
Oropharyngeal spasm	20.45	15.02	12	190898	488	110397901
Fistula of small intestine	20.33	15.02	16	190894	1059	110397330
Type IV hypersensitivity reaction	20.32	15.02	37	190873	5996	110392393
Adverse reaction	20.30	15.02	13	190897	29581	110368808
Mood swings	20.29	15.02	7	190903	22805	110375584
Interventricular septum rupture	20.29	15.02	6	190904	38	110398351
White blood cell count increased	20.24	15.02	92	190818	96750	110301639
Blood albumin decreased	20.23	15.02	98	190812	27554	110370835
Aortic dissection	20.22	15.02	33	190877	4900	110393489
Nodule	20.20	15.02	16	190894	32615	110365774
Blood triglycerides increased	20.17	15.02	8	190902	23918	110374471
Sinus bradycardia	20.16	15.02	13	190897	29470	110368919
Monocytopenia	20.11	15.02	9	190901	205	110398184
Therapeutic response unexpected	20.06	15.02	8	190902	23835	110374554
Pancreatic carcinoma metastatic	20.05	15.02	30	190880	4134	110394255
Bile duct necrosis	19.96	15.02	7	190903	81	110398308
Gastric disorder	19.85	15.02	17	190893	33340	110365049
Minimal residual disease	19.80	15.02	15	190895	938	110397451
Colon cancer	19.80	15.02	68	190842	16375	110382014
Necrotic lymphadenopathy	19.79	15.02	9	190901	213	110398176
Glycosylated haemoglobin increased	19.75	15.02	8	190902	23611	110374778
Toothache	19.69	15.02	8	190902	23567	110374822
Limbic encephalitis	19.68	15.02	14	190896	794	110397595
Allodynia	19.66	15.02	21	190889	2062	110396327
Renal hydrocele	19.66	15.02	6	190904	43	110398346
Musculoskeletal discomfort	19.64	15.02	8	190902	23530	110374859
Jugular vein thrombosis	19.57	15.02	34	190876	5311	110393078
Pancreatic neuroendocrine tumour metastatic	19.52	15.02	9	190901	220	110398169
Neutropenic infection	19.51	15.02	26	190884	3219	110395170
Eye disorder	19.42	15.02	13	190897	28893	110369496
Hepatic infarction	19.41	15.02	15	190895	966	110397423
Mental disorder	19.39	15.02	23	190887	38768	110359621
Gastroenteritis aeromonas	19.30	15.02	6	190904	46	110398343
Biliary abscess	19.19	15.02	6	190904	47	110398342
Immune system disorder	19.11	15.02	59	190851	13442	110384947
Oesophageal stenosis	19.10	15.02	33	190877	5132	110393257
Dementia	19.02	15.02	16	190894	31657	110366732
Chemotherapy cardiotoxicity attenuation	19.01	15.02	5	190905	19	110398370
Jaundice cholestatic	19.00	15.02	62	190848	14546	110383843
Venous thrombosis	18.98	15.02	44	190866	8461	110389928
Venoocclusive disease	18.97	15.02	37	190873	6313	110392076
Lymphatic duct injury	18.87	15.02	6	190904	50	110398339
Respiratory tract infection	18.85	15.02	62	190848	71555	110326834
Circulatory collapse	18.81	15.02	133	190777	42860	110355529
Vaginal discharge	18.74	15.02	4	190906	17904	110380485
Intrahepatic portal hepatic venous fistula	18.69	15.02	4	190906	4	110398385
Neonatal asphyxia	18.69	15.02	4	190906	4	110398385
Product administration error	18.68	15.02	22	190888	37195	110361194
Depressed mood	18.65	15.02	49	190861	60760	110337629
Hypoacusis	18.53	15.02	20	190890	35171	110363218
Rectosigmoid cancer	18.51	15.02	10	190900	346	110398043
Hip fracture	18.49	15.02	20	190890	35131	110363258
Neuroectodermal neoplasm	18.42	15.02	5	190905	22	110398367
Immune-mediated nephritis	18.42	15.02	16	190894	1216	110397173
Mental impairment	18.39	15.02	8	190902	22631	110375758
Taste disorder	18.34	15.02	55	190855	65332	110333057
Tonic clonic movements	18.29	15.02	24	190886	2928	110395461
Haemoglobin abnormal	18.27	15.02	45	190865	8993	110389396
Angina pectoris	18.25	15.02	176	190734	62119	110336270
Portal vein embolisation	18.24	15.02	5	190905	23	110398366
Myoclonus	18.23	15.02	18	190892	32980	110365409
Hyperlipidaemia	18.19	15.02	21	190889	35827	110362562
Sneezing	18.19	15.02	17	190893	31967	110366422
Fistula	18.18	15.02	63	190847	15236	110383153
Dystonia	18.17	15.02	11	190899	25794	110372595
Endometrial dysplasia	18.07	15.02	5	190905	24	110398365
Cardiac murmur	18.05	15.02	10	190900	24618	110373771
Vena cava thrombosis	18.02	15.02	26	190884	3468	110394921
Acute polyneuropathy	18.00	15.02	13	190897	755	110397634
Embolism arterial	18	15.02	19	190891	1840	110396549
Proctalgia	17.99	15.02	57	190853	13165	110385224
Osteomyelitis	17.98	15.02	22	190888	36578	110361811
Macroglossia	17.96	15.02	17	190893	1444	110396945
Mechanical ileus	17.92	15.02	16	190894	1261	110397128
Duodenal perforation	17.91	15.02	23	190887	2747	110395642
Liver ablation	17.90	15.02	5	190905	25	110398364
Lacrimation disorder	17.90	15.02	5	190905	25	110398364
Kidney infection	17.90	15.02	11	190899	25588	110372801
Skin discolouration	17.89	15.02	36	190874	49010	110349379
Device malfunction	17.84	15.02	11	190899	25547	110372842
Hyperchylomicronaemia	17.81	15.02	6	190904	61	110398328
Oesophageal fistula	17.80	15.02	11	190899	492	110397897
Prostatic calcification	17.79	15.02	7	190903	114	110398275
Hiatus hernia	17.77	15.02	13	190897	27593	110370796
Growth of eyelashes	17.60	15.02	8	190902	189	110398200
Upper limb fracture	17.59	15.02	7	190903	20881	110377508
Radiation interaction	17.55	15.02	6	190904	64	110398325
Akathisia	17.55	15.02	4	190906	17109	110381280
Angioedema	17.50	15.02	99	190811	98401	110299988
Chronic kidney disease	17.47	15.02	70	190840	76221	110322168
Sensitisation	17.33	15.02	28	190882	4123	110394266
Intestinal dilatation	17.32	15.02	26	190884	3594	110394795
Duodenal stenosis	17.32	15.02	14	190896	963	110397426
Pancreatic carcinoma recurrent	17.23	15.02	8	190902	199	110398190
Dyspnoea exertional	17.21	15.02	107	190803	103953	110294436
Atypical haemolytic uraemic syndrome	17.20	15.02	17	190893	1523	110396866
Lethargy	17.20	15.02	93	190817	93483	110304906
Eye infection gonococcal	17.14	15.02	5	190905	30	110398359
Retroperitoneal mass	17.10	15.02	9	190901	295	110398094
Necrosis ischaemic	17.06	15.02	16	190894	1343	110397046
Splenic abscess	17.03	15.02	14	190896	986	110397403
VIth nerve disorder	17.00	15.02	5	190905	31	110398358
Hypoproteinaemia	16.99	15.02	34	190876	5911	110392478
Hypothermia	16.99	15.02	90	190820	26212	110372177
Pulmonary congestion	16.98	15.02	17	190893	30949	110367440
Gastrointestinal stoma output increased	16.98	15.02	14	190896	990	110397399
Aphasia	16.95	15.02	166	190744	58831	110339558
Blindness transient	16.95	15.02	34	190876	5922	110392467
Pneumonitis chemical	16.94	15.02	12	190898	676	110397713
Seizure	16.94	15.02	274	190636	220911	110177478
Mesenteric vein thrombosis	16.89	15.02	19	190891	1976	110396413
Systemic infection	16.88	15.02	46	190864	9773	110388616
Mucosal necrosis	16.87	15.02	8	190902	209	110398180
Papillary cystadenoma lymphomatosum	16.83	15.02	8	190902	210	110398179
Cerebral amyloid angiopathy	16.81	15.02	11	190899	544	110397845
Metastases to retroperitoneum	16.79	15.02	10	190900	418	110397971
Disturbance in attention	16.78	15.02	53	190857	61942	110336447
Oesophageal carcinoma recurrent	16.77	15.02	6	190904	74	110398315
Amaurosis	16.75	15.02	17	190893	1572	110396817
Assisted suicide	16.73	15.02	5	190905	33	110398356
Mood altered	16.67	15.02	8	190902	21367	110377022
Renal disorder	16.64	15.02	38	190872	49441	110348948
Post procedural bile leak	16.62	15.02	10	190900	426	110397963
Transient aphasia	16.62	15.02	12	190898	697	110397692
Bleeding varicose vein	16.56	15.02	12	190898	701	110397688
Rectal stenosis	16.56	15.02	10	190900	429	110397960
Transposition of the great vessels	16.55	15.02	6	190904	77	110398312
Tumour pseudoprogression	16.51	15.02	17	190893	1599	110396790
Hypertension	16.50	15.02	1056	189854	509028	109889361
Paravenous drug administration	16.46	15.02	4	190906	10	110398379
Drug tolerance decreased	16.43	15.02	14	190896	27526	110370863
Catabolic state	16.41	15.02	6	190904	79	110398310
Pelvic venous thrombosis	16.40	15.02	22	190888	2742	110395647
Immune-mediated pancreatitis	16.39	15.02	12	190898	712	110397677
Blood alkaline phosphatase increased	16.37	15.02	191	190719	70744	110327645
Gastrointestinal oedema	16.22	15.02	24	190886	3274	110395115
Visual impairment	16.19	15.02	151	190759	134277	110264112
Rectourethral fistula	16.19	15.02	4	190906	11	110398378
Sedation complication	16.16	15.02	7	190903	19848	110378541
Vasculitis	16.15	15.02	23	190887	35850	110362539
Venous thrombosis limb	16.13	15.02	31	190879	5234	110393155
Prostate cancer	16.10	15.02	25	190885	37616	110360773
Neuronal neuropathy	16.09	15.02	3	190907	0	110398389
Carcinoembryonic antigen decreased	16.09	15.02	3	190907	0	110398389
Thrombocytosis	16.06	15.02	47	190863	10397	110387992
Dysstasia	16.02	15.02	20	190890	32966	110365423
Ligament sprain	15.99	15.02	4	190906	16064	110382325
Peripheral blood stem cell apheresis	15.95	15.02	7	190903	152	110398237
Gastrointestinal wall thickening	15.90	15.02	25	190885	3598	110394791
Hypocapnia	15.89	15.02	13	190897	909	110397480
Biliary dilatation	15.89	15.02	25	190885	3600	110394789
Pain in jaw	15.88	15.02	41	190869	51136	110347253
Blood alkaline phosphatase abnormal	15.87	15.02	15	190895	1272	110397117
Bacterial colitis	15.82	15.02	8	190902	241	110398148
Movement disorder	15.75	15.02	24	190886	36380	110362009
Biloma	15.73	15.02	8	190902	244	110398145
Cerebral vasoconstriction	15.72	15.02	16	190894	1485	110396904
Induration	15.70	15.02	20	190890	2369	110396020
Colon cancer stage IV	15.68	15.02	10	190900	473	110397916
Skin haemorrhage	15.59	15.02	12	190898	24815	110373574
Acute generalised exanthematous pustulosis	15.58	15.02	9	190901	21655	110376734
Wrist fracture	15.54	15.02	3	190907	14414	110383975
Xerophthalmia	15.54	15.02	13	190897	938	110397451
Mucocutaneous rash	15.46	15.02	6	190904	94	110398295
Left ventricular failure	15.41	15.02	49	190861	11340	110387049
Retroperitoneal neoplasm metastatic	15.38	15.02	5	190905	45	110398344
Pruritus	15.34	15.02	1184	189726	580376	109818013
Tongue paralysis	15.34	15.02	11	190899	632	110397757
Coombs test positive	15.32	15.02	8	190902	258	110398131
Glaucoma	15.30	15.02	10	190900	22507	110375882
Blood test abnormal	15.29	15.02	16	190894	28538	110369851
Malignant gastrointestinal obstruction	15.29	15.02	5	190905	46	110398343
Amylase increased	15.27	15.02	52	190858	12467	110385922
Cerebral haemorrhage	15.26	15.02	59	190851	64909	110333480
Lymphadenopathy mediastinal	15.24	15.02	31	190879	5453	110392936
Vaginal cellulitis	15.23	15.02	6	190904	98	110398291
Gastrointestinal fistula	15.17	15.02	13	190897	970	110397419
Neuromyopathy	15.16	15.02	17	190893	1762	110396627
Perirectal abscess	15.16	15.02	19	190891	2215	110396174
Livedo reticularis	15.15	15.02	31	190879	5475	110392914
Capillary nail refill test abnormal	15.12	15.02	6	190904	100	110398289
Anal sphincter atony	15.09	15.02	10	190900	505	110397884
Tunnel vision	15.07	15.02	18	190892	1997	110396392
Eye swelling	15.07	15.02	21	190889	33027	110365362

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Craniosynostosis	50.95	38.06	9	15	59	113870

Pharmacologic Action:

Source	Code	Description
ATC	L01XA03	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Platinum compounds
FDA EXT	N0000175073	Platinum-containing Compounds
FDA EPC	N0000175413	Platinum-based Drug
MeSH PA	D000970	Antineoplastic Agents
CHEBI has role	CHEBI:25435	mutagen
CHEBI has role	CHEBI:35610	antineoplastic agent

Related Drugs by ATC class:

L01XA Platinum compounds 3 drugs

carboplatin cisplatin satraplatin

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Metastasis from malignant tumor of colon	indication	314998002
Malignant tumor of stomach	indication	363349007	DOID:10534
Small intestine cancer	indication	363509000	DOID:10154
Lymph Node Positive Colorectal Carcinoma	indication
Malignant tumor of colon	off-label use	363406005	DOID:219
Malignant tumor of testis	off-label use	363449006	DOID:2998
Adenocarcinoma of pancreas	off-label use	700423003	DOID:4074
Fibrosis of lung	contraindication	51615001	DOID:3770
Interstitial pneumonia	contraindication	64667001
Kidney disease	contraindication	90708001	DOID:557
Liver function tests abnormal	contraindication	166603001
Disease of liver	contraindication	235856003	DOID:409
Pregnancy, function	contraindication	289908002
Peripheral nerve disease	contraindication	302226006
Breastfeeding (mother)	contraindication	413712001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4021355	VUID
N0000148774	NUI
D01790	KEGG_DRUG
4021355	VANDF
C0069717	UMLSCUI
CHEBI:31941	CHEBI
1PT	PDB_CHEM_ID
CHEMBL414804	ChEMBL_ID
D000077150	MESH_DESCRIPTOR_UI
DB00526	DRUGBANK_ID
7433	IUPHAR_LIGAND_ID
6012	INN_ID
04ZR38536J	UNII
9887053	PUBCHEM_CID
32592	RXNORM
165344	MMSL
16916	MMSL
d04811	MMSL
007166	NDDF
327032007	SNOMEDCT_US
395814003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0781-3315	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	29 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0781-3317	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	29 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0781-9315	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	28 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0781-9317	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	28 sections
OXALIPLATIN	HUMAN PRESCRIPTION DRUG LABEL	1	0955-1731	INJECTION, SOLUTION, CONCENTRATE	5 mg	INTRAVENOUS	NDA authorized generic	33 sections
OXALIPLATIN	HUMAN PRESCRIPTION DRUG LABEL	1	0955-1733	INJECTION, SOLUTION, CONCENTRATE	5 mg	INTRAVENOUS	NDA authorized generic	33 sections
oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	16729-332	INJECTION, SOLUTION, CONCENTRATE	5 mg	INTRAVENOUS	ANDA	30 sections
oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	25021-233	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	28 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	31722-357	INJECTION, SOLUTION, CONCENTRATE	50 mg	INTRAVENOUS	ANDA	28 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	31722-358	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	28 sections
oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	42677-336	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	20 sections
oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	42677-337	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	20 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	43066-014	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	28 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	43066-018	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	28 sections
Oxaliplatin	Human Prescription Drug Label	1	47335-046	INJECTION, SOLUTION, CONCENTRATE	50 mg	INTRAVENOUS	ANDA	27 sections
Oxaliplatin	Human Prescription Drug Label	1	47335-047	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	27 sections
Oxaliplatin	Human Prescription Drug Label	1	47335-176	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	50 mg	INTRAVENOUS	ANDA	28 sections
Oxaliplatin	Human Prescription Drug Label	1	47335-178	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	100 mg	INTRAVENOUS	ANDA	28 sections
Oxaliplatin	Human Prescription Drug Label	1	55150-331	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	29 sections
Oxaliplatin	Human Prescription Drug Label	1	55150-332	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	29 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	57277-001	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	26 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	57277-002	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	26 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	60505-6132	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	25 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	60505-6287	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	25 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	61703-363	INJECTION, SOLUTION, CONCENTRATE	5 mg	INTRAVENOUS	ANDA	33 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	63323-750	INJECTION, SOLUTION, CONCENTRATE	5 mg	INTRAVENOUS	ANDA	28 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	67184-0501	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	50 mg	INTRAVENOUS	ANDA	25 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	67184-0502	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	100 mg	INTRAVENOUS	ANDA	25 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	67184-0508	INJECTION, SOLUTION	50 mg	INTRAVENOUS	ANDA	25 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	67184-0509	INJECTION, SOLUTION	100 mg	INTRAVENOUS	ANDA	25 sections

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oxaliplatin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products: