Stem definition | Drug id | CAS RN |
---|---|---|
antineoplastic agents, platinum derivatives | 4210 | 61825-94-3 |
Molecule | Description |
---|---|
Synonyms:
|
An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS.
|
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 6 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 8.13 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Vd (Volume of distribution) | 0.50 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.10 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.13 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 58.92 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 9, 2002 | FDA | ||
March 18, 2005 | PMDA | Yakult Honsha |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neuropathy peripheral | 992.43 | 17.06 | 835 | 55122 | 95922 | 50453245 |
Laryngospasm | 906.12 | 17.06 | 260 | 55697 | 2428 | 50546739 |
Neutropenia | 900.85 | 17.06 | 956 | 55001 | 147009 | 50402158 |
Neurotoxicity | 664.79 | 17.06 | 325 | 55632 | 14415 | 50534752 |
Thrombocytopenia | 640.35 | 17.06 | 746 | 55211 | 126927 | 50422240 |
Diarrhoea | 565.12 | 17.06 | 1671 | 54286 | 586805 | 49962362 |
Disease progression | 548.26 | 17.06 | 600 | 55357 | 95266 | 50453901 |
Mucosal inflammation | 445.12 | 17.06 | 363 | 55594 | 39779 | 50509388 |
Palmar-plantar erythrodysaesthesia syndrome | 414.58 | 17.06 | 265 | 55692 | 19833 | 50529334 |
Paraesthesia | 400.23 | 17.06 | 574 | 55383 | 119669 | 50429498 |
Vomiting | 378.16 | 17.06 | 1241 | 54716 | 459517 | 50089650 |
Drug ineffective | 315.23 | 17.06 | 268 | 55689 | 819065 | 49730102 |
Bone marrow failure | 312.87 | 17.06 | 253 | 55704 | 27371 | 50521796 |
Dysarthria | 301.21 | 17.06 | 282 | 55675 | 37121 | 50512046 |
Stridor | 300.60 | 17.06 | 118 | 55839 | 3051 | 50546116 |
Dermatitis acneiform | 295.53 | 17.06 | 125 | 55832 | 3932 | 50545235 |
Peripheral sensory neuropathy | 287.13 | 17.06 | 142 | 55815 | 6449 | 50542718 |
Bronchospasm | 282.09 | 17.06 | 186 | 55771 | 14668 | 50534499 |
Throat tightness | 277.33 | 17.06 | 210 | 55747 | 20637 | 50528530 |
Myelosuppression | 258.49 | 17.06 | 170 | 55787 | 13347 | 50535820 |
Polyneuropathy | 250.23 | 17.06 | 160 | 55797 | 11971 | 50537196 |
Arthralgia | 244.89 | 17.06 | 90 | 55867 | 438612 | 50110555 |
Dysaesthesia pharynx | 242.02 | 17.06 | 51 | 55906 | 97 | 50549070 |
Skin toxicity | 240.68 | 17.06 | 107 | 55850 | 3806 | 50545361 |
Nausea | 215.70 | 17.06 | 1422 | 54535 | 703976 | 49845191 |
Joint swelling | 207.72 | 17.06 | 17 | 55940 | 245269 | 50303898 |
Arteriospasm coronary | 202.75 | 17.06 | 91 | 55866 | 3311 | 50545856 |
Febrile neutropenia | 201.70 | 17.06 | 376 | 55581 | 97291 | 50451876 |
Gastrointestinal toxicity | 198.49 | 17.06 | 99 | 55858 | 4578 | 50544589 |
Metastases to liver | 190.16 | 17.06 | 166 | 55791 | 19938 | 50529229 |
Haematotoxicity | 187.75 | 17.06 | 114 | 55843 | 7781 | 50541386 |
Gastrointestinal perforation | 186.01 | 17.06 | 83 | 55874 | 2978 | 50546189 |
Headache | 181.69 | 17.06 | 176 | 55781 | 506359 | 50042808 |
Pain | 172.13 | 17.06 | 234 | 55723 | 578669 | 49970498 |
Neutrophil count decreased | 168.10 | 17.06 | 230 | 55727 | 45796 | 50503371 |
Product dose omission issue | 166.56 | 17.06 | 9 | 55948 | 183829 | 50365338 |
Leukopenia | 166.46 | 17.06 | 281 | 55676 | 67247 | 50481920 |
Posterior reversible encephalopathy syndrome | 163.24 | 17.06 | 134 | 55823 | 14794 | 50534373 |
Malignant neoplasm progression | 159.39 | 17.06 | 277 | 55680 | 67847 | 50481320 |
Arthropathy | 155.76 | 17.06 | 4 | 55953 | 157902 | 50391265 |
Sinusitis | 155.61 | 17.06 | 8 | 55949 | 170550 | 50378617 |
Swelling | 154.33 | 17.06 | 20 | 55937 | 200852 | 50348315 |
Enteritis | 153.59 | 17.06 | 96 | 55861 | 6899 | 50542268 |
Dyspnoea | 148.39 | 17.06 | 1073 | 54884 | 546535 | 50002632 |
Erythema | 147.70 | 17.06 | 425 | 55532 | 145989 | 50403178 |
Weight increased | 143.86 | 17.06 | 25 | 55932 | 201866 | 50347301 |
Non-cirrhotic portal hypertension | 142.53 | 17.06 | 34 | 55923 | 138 | 50549029 |
Dehydration | 139.04 | 17.06 | 427 | 55530 | 152022 | 50397145 |
Nasopharyngitis | 137.22 | 17.06 | 24 | 55933 | 192903 | 50356264 |
Contraindicated product administered | 135.83 | 17.06 | 7 | 55950 | 148951 | 50400216 |
Systemic lupus erythematosus | 133.51 | 17.06 | 5 | 55952 | 140617 | 50408550 |
Maternal exposure during pregnancy | 127.42 | 17.06 | 14 | 55943 | 159764 | 50389403 |
Venoocclusive liver disease | 123.64 | 17.06 | 70 | 55887 | 4191 | 50544976 |
Portal hypertension | 121.35 | 17.06 | 64 | 55893 | 3328 | 50545839 |
Abdominal pain | 119.24 | 17.06 | 547 | 55410 | 235681 | 50313486 |
Fall | 119.11 | 17.06 | 117 | 55840 | 334815 | 50214352 |
Pemphigus | 118.65 | 17.06 | 3 | 55954 | 120163 | 50429004 |
Laryngeal oedema | 117.67 | 17.06 | 72 | 55885 | 4981 | 50544186 |
Ascites | 115.81 | 17.06 | 169 | 55788 | 35692 | 50513475 |
Abdominal discomfort | 113.84 | 17.06 | 57 | 55900 | 231584 | 50317583 |
Chills | 113.69 | 17.06 | 297 | 55660 | 96390 | 50452777 |
Anaphylactic shock | 111.20 | 17.06 | 124 | 55833 | 20031 | 50529136 |
Hyperammonaemia | 109.21 | 17.06 | 67 | 55890 | 4657 | 50544510 |
Paronychia | 108.76 | 17.06 | 66 | 55891 | 4498 | 50544669 |
Peripheral swelling | 108.44 | 17.06 | 46 | 55911 | 205890 | 50343277 |
Glossodynia | 106.72 | 17.06 | 5 | 55952 | 115564 | 50433603 |
Therapeutic product effect decreased | 105.78 | 17.06 | 13 | 55944 | 136037 | 50413130 |
Dysphonia | 105.44 | 17.06 | 169 | 55788 | 38723 | 50510444 |
Immune thrombocytopenia | 105.04 | 17.06 | 84 | 55873 | 8933 | 50540234 |
Depression | 104.48 | 17.06 | 27 | 55930 | 165396 | 50383771 |
Splenomegaly | 104.11 | 17.06 | 86 | 55871 | 9574 | 50539593 |
Dysaesthesia | 102.05 | 17.06 | 59 | 55898 | 3676 | 50545491 |
Insomnia | 98.76 | 17.06 | 35 | 55922 | 174830 | 50374337 |
Paraesthesia oral | 98.03 | 17.06 | 92 | 55865 | 12129 | 50537038 |
Wound | 96.33 | 17.06 | 5 | 55952 | 105789 | 50443378 |
Speech disorder | 94.35 | 17.06 | 153 | 55804 | 35395 | 50513772 |
Colorectal cancer metastatic | 93.49 | 17.06 | 31 | 55926 | 484 | 50548683 |
Product use issue | 91.37 | 17.06 | 26 | 55931 | 149449 | 50399718 |
Focal nodular hyperplasia | 90.55 | 17.06 | 30 | 55927 | 467 | 50548700 |
Tongue oedema | 90.16 | 17.06 | 55 | 55902 | 3784 | 50545383 |
Intestinal perforation | 90.09 | 17.06 | 82 | 55875 | 10397 | 50538770 |
Intestinal obstruction | 89.07 | 17.06 | 127 | 55830 | 26256 | 50522911 |
Bronchitis | 88.68 | 17.06 | 7 | 55950 | 104152 | 50445015 |
Stomatitis | 87.80 | 17.06 | 279 | 55678 | 101065 | 50448102 |
Large intestine perforation | 87.69 | 17.06 | 70 | 55887 | 7424 | 50541743 |
Nodular regenerative hyperplasia | 85.81 | 17.06 | 25 | 55932 | 247 | 50548920 |
Lower respiratory tract infection | 85.12 | 17.06 | 5 | 55952 | 95196 | 50453971 |
Metastases to lung | 84.66 | 17.06 | 81 | 55876 | 10939 | 50538228 |
Anaemia | 83.78 | 17.06 | 521 | 55436 | 251935 | 50297232 |
Cardiotoxicity | 83.00 | 17.06 | 66 | 55891 | 6961 | 50542206 |
Neuromyotonia | 82.63 | 17.06 | 18 | 55939 | 43 | 50549124 |
Asthma | 82.04 | 17.06 | 4 | 55953 | 89333 | 50459834 |
Decreased appetite | 80.53 | 17.06 | 436 | 55521 | 200487 | 50348680 |
Dysphagia | 79.00 | 17.06 | 226 | 55731 | 77292 | 50471875 |
Hypomagnesaemia | 77.48 | 17.06 | 111 | 55846 | 23045 | 50526122 |
Drug intolerance | 77.26 | 17.06 | 77 | 55880 | 219027 | 50330140 |
Asthenia | 76.87 | 17.06 | 609 | 55348 | 318433 | 50230734 |
Stress cardiomyopathy | 76.33 | 17.06 | 66 | 55891 | 7821 | 50541346 |
Influenza | 76.26 | 17.06 | 6 | 55951 | 89532 | 50459635 |
Hypokalaemia | 75.99 | 17.06 | 242 | 55715 | 87750 | 50461417 |
Flushing | 75.83 | 17.06 | 203 | 55754 | 66812 | 50482355 |
Laryngeal discomfort | 71.80 | 17.06 | 22 | 55935 | 262 | 50548905 |
Injection site pain | 70.31 | 17.06 | 18 | 55939 | 111006 | 50438161 |
Metastases to peritoneum | 70.17 | 17.06 | 42 | 55915 | 2791 | 50546376 |
Therapy partial responder | 69.62 | 17.06 | 58 | 55899 | 6533 | 50542634 |
Pain in extremity | 69.54 | 17.06 | 122 | 55835 | 272743 | 50276424 |
Exposure during pregnancy | 68.68 | 17.06 | 24 | 55933 | 120991 | 50428176 |
Anastomotic leak | 67.44 | 17.06 | 23 | 55934 | 393 | 50548774 |
Condition aggravated | 66.86 | 17.06 | 143 | 55814 | 296915 | 50252252 |
Hyperammonaemic encephalopathy | 66.67 | 17.06 | 36 | 55921 | 1963 | 50547204 |
Pyrexia | 65.12 | 17.06 | 674 | 55283 | 379529 | 50169638 |
Hypertension | 64.54 | 17.06 | 427 | 55530 | 210776 | 50338391 |
Musculoskeletal stiffness | 63.99 | 17.06 | 31 | 55926 | 128450 | 50420717 |
Ileus | 63.89 | 17.06 | 76 | 55881 | 13153 | 50536014 |
Haemolytic anaemia | 63.37 | 17.06 | 64 | 55893 | 9228 | 50539939 |
Arthritis | 63.35 | 17.06 | 10 | 55947 | 86711 | 50462456 |
Drug hypersensitivity | 63.25 | 17.06 | 113 | 55844 | 250897 | 50298270 |
Hospitalisation | 62.51 | 17.06 | 3 | 55954 | 67934 | 50481233 |
Pericarditis | 62.43 | 17.06 | 7 | 55950 | 78682 | 50470485 |
Contusion | 62.38 | 17.06 | 23 | 55934 | 112160 | 50437007 |
Platelet count decreased | 62.07 | 17.06 | 248 | 55709 | 100478 | 50448689 |
Oxygen saturation decreased | 61.91 | 17.06 | 200 | 55757 | 73048 | 50476119 |
Hepatic enzyme increased | 61.37 | 17.06 | 38 | 55919 | 137342 | 50411825 |
Injection site erythema | 61.16 | 17.06 | 6 | 55951 | 74930 | 50474237 |
General physical health deterioration | 60.37 | 17.06 | 314 | 55643 | 142120 | 50407047 |
Hyperhidrosis | 59.84 | 17.06 | 226 | 55731 | 89200 | 50459967 |
Peritonitis | 58.95 | 17.06 | 79 | 55878 | 15407 | 50533760 |
Interstitial lung disease | 58.06 | 17.06 | 159 | 55798 | 53017 | 50496150 |
Tumour perforation | 57.21 | 17.06 | 15 | 55942 | 96 | 50549071 |
Cardiac failure congestive | 56.75 | 17.06 | 12 | 55945 | 84370 | 50464797 |
Anaphylactic reaction | 56.42 | 17.06 | 159 | 55798 | 53896 | 50495271 |
Hyperthermia | 56.17 | 17.06 | 55 | 55902 | 7641 | 50541526 |
Hypertensive crisis | 56.14 | 17.06 | 71 | 55886 | 13083 | 50536084 |
Enterocutaneous fistula | 56.03 | 17.06 | 27 | 55930 | 1157 | 50548010 |
Chemical peritonitis | 53.75 | 17.06 | 14 | 55943 | 87 | 50549080 |
Treatment failure | 53.70 | 17.06 | 44 | 55913 | 137593 | 50411574 |
Alopecia | 53.43 | 17.06 | 120 | 55837 | 244927 | 50304240 |
Enterocolitis | 51.83 | 17.06 | 49 | 55908 | 6518 | 50542649 |
Neoplasm progression | 51.27 | 17.06 | 105 | 55852 | 29052 | 50520115 |
Drug abuse | 50.99 | 17.06 | 4 | 55953 | 59842 | 50489325 |
Metastases to meninges | 50.42 | 17.06 | 30 | 55927 | 1972 | 50547195 |
Feeling hot | 49.73 | 17.06 | 124 | 55833 | 39078 | 50510089 |
Hydronephrosis | 49.62 | 17.06 | 54 | 55903 | 8487 | 50540680 |
Suicidal ideation | 49.22 | 17.06 | 3 | 55954 | 55382 | 50493785 |
Gait disturbance | 49.17 | 17.06 | 56 | 55901 | 149949 | 50399218 |
Diffuse large B-cell lymphoma recurrent | 48.44 | 17.06 | 27 | 55930 | 1568 | 50547599 |
Colitis | 47.96 | 17.06 | 121 | 55836 | 38408 | 50510759 |
Neutropenic colitis | 47.66 | 17.06 | 31 | 55926 | 2386 | 50546781 |
Drug interaction | 47.49 | 17.06 | 93 | 55864 | 199528 | 50349639 |
Somnolence | 47.47 | 17.06 | 61 | 55896 | 154924 | 50394243 |
Blood lactate dehydrogenase abnormal | 47.14 | 17.06 | 15 | 55942 | 204 | 50548963 |
Rectal perforation | 46.11 | 17.06 | 17 | 55940 | 368 | 50548799 |
Band sensation | 46.09 | 17.06 | 20 | 55937 | 670 | 50548497 |
Varices oesophageal | 45.96 | 17.06 | 32 | 55925 | 2757 | 50546410 |
Disseminated intravascular coagulation | 45.79 | 17.06 | 74 | 55883 | 17061 | 50532106 |
Suicide attempt | 45.39 | 17.06 | 3 | 55954 | 51729 | 50497438 |
Pneumonia | 45.30 | 17.06 | 240 | 55717 | 378161 | 50171006 |
Extravasation | 45.27 | 17.06 | 28 | 55929 | 1974 | 50547193 |
Upper respiratory tract infection | 45.08 | 17.06 | 9 | 55948 | 65889 | 50483278 |
Evans syndrome | 44.93 | 17.06 | 14 | 55943 | 177 | 50548990 |
Off label use | 44.23 | 17.06 | 753 | 55204 | 473673 | 50075494 |
Diffuse large B-cell lymphoma refractory | 43.96 | 17.06 | 22 | 55935 | 1024 | 50548143 |
Cough | 43.49 | 17.06 | 130 | 55827 | 241134 | 50308033 |
Proteinuria | 43.44 | 17.06 | 71 | 55886 | 16526 | 50532641 |
Suffocation feeling | 43.30 | 17.06 | 23 | 55934 | 1213 | 50547954 |
Helicobacter infection | 43.26 | 17.06 | 3 | 55954 | 49699 | 50499468 |
Hypertransaminasaemia | 42.82 | 17.06 | 34 | 55923 | 3577 | 50545590 |
Cholinergic syndrome | 42.58 | 17.06 | 16 | 55941 | 366 | 50548801 |
Injury | 42.45 | 17.06 | 3 | 55954 | 48922 | 50500245 |
Steatohepatitis | 42.43 | 17.06 | 17 | 55940 | 464 | 50548703 |
Neutrophil count abnormal | 42.37 | 17.06 | 29 | 55928 | 2430 | 50546737 |
Choking sensation | 42.19 | 17.06 | 32 | 55925 | 3148 | 50546019 |
Carcinoembryonic antigen increased | 42.18 | 17.06 | 24 | 55933 | 1450 | 50547717 |
Stress | 42.13 | 17.06 | 5 | 55952 | 53788 | 50495379 |
Dihydropyrimidine dehydrogenase deficiency | 42.01 | 17.06 | 11 | 55946 | 70 | 50549097 |
Mucosal toxicity | 41.47 | 17.06 | 15 | 55942 | 307 | 50548860 |
Overdose | 41.28 | 17.06 | 30 | 55927 | 99697 | 50449470 |
Cold dysaesthesia | 40.93 | 17.06 | 8 | 55949 | 8 | 50549159 |
Injection site reaction | 40.84 | 17.06 | 4 | 55953 | 50028 | 50499139 |
Hepatic failure | 40.83 | 17.06 | 102 | 55855 | 32181 | 50516986 |
Cataract | 40.75 | 17.06 | 3 | 55954 | 47297 | 50501870 |
Splenic artery thrombosis | 40.73 | 17.06 | 10 | 55947 | 47 | 50549120 |
Factor VII deficiency | 40.34 | 17.06 | 9 | 55948 | 25 | 50549142 |
Sensation of foreign body | 40.25 | 17.06 | 34 | 55923 | 3902 | 50545265 |
Intentional product misuse | 40.16 | 17.06 | 3 | 55954 | 46731 | 50502436 |
Anxiety | 39.48 | 17.06 | 86 | 55871 | 177520 | 50371647 |
Chronic obstructive pulmonary disease | 39.39 | 17.06 | 6 | 55951 | 53429 | 50495738 |
Acute coronary syndrome | 39.06 | 17.06 | 50 | 55907 | 9324 | 50539843 |
Duodenal ulcer perforation | 38.99 | 17.06 | 3 | 55954 | 45608 | 50503559 |
Tachycardia | 38.88 | 17.06 | 215 | 55742 | 99548 | 50449619 |
Hypertrichosis | 38.84 | 17.06 | 20 | 55937 | 989 | 50548178 |
Cardiac ventricular thrombosis | 38.84 | 17.06 | 16 | 55941 | 470 | 50548697 |
Acute polyneuropathy | 38.79 | 17.06 | 13 | 55944 | 210 | 50548957 |
White blood cell count decreased | 38.68 | 17.06 | 241 | 55716 | 116481 | 50432686 |
Leukoencephalopathy | 38.60 | 17.06 | 33 | 55924 | 3850 | 50545317 |
Tremor | 38.55 | 17.06 | 238 | 55719 | 114665 | 50434502 |
Cystitis radiation | 38.41 | 17.06 | 10 | 55947 | 62 | 50549105 |
Discomfort | 38.26 | 17.06 | 38 | 55919 | 108342 | 50440825 |
Short-bowel syndrome | 38.09 | 17.06 | 15 | 55942 | 391 | 50548776 |
Infusion related hypersensitivity reaction | 38.01 | 17.06 | 10 | 55947 | 65 | 50549102 |
Bladder tamponade | 37.24 | 17.06 | 10 | 55947 | 71 | 50549096 |
Atypical haemolytic uraemic syndrome | 36.73 | 17.06 | 16 | 55941 | 541 | 50548626 |
Formication | 36.27 | 17.06 | 31 | 55926 | 3615 | 50545552 |
Female genital tract fistula | 36.13 | 17.06 | 31 | 55926 | 3635 | 50545532 |
Fatigue | 35.92 | 17.06 | 559 | 55398 | 707042 | 49842125 |
Cytokine release syndrome | 35.89 | 17.06 | 46 | 55911 | 8588 | 50540579 |
Osteoporosis | 35.57 | 17.06 | 4 | 55953 | 44875 | 50504292 |
Pancytopenia | 35.39 | 17.06 | 185 | 55772 | 83845 | 50465322 |
Ileal perforation | 35.19 | 17.06 | 14 | 55943 | 375 | 50548792 |
Multiple organ dysfunction syndrome | 35.14 | 17.06 | 129 | 55828 | 50208 | 50498959 |
Laryngeal dyspnoea | 35.02 | 17.06 | 11 | 55946 | 143 | 50549024 |
Thrombocytopenic purpura | 34.89 | 17.06 | 20 | 55937 | 1226 | 50547941 |
Large intestinal obstruction | 34.72 | 17.06 | 23 | 55934 | 1826 | 50547341 |
Pharyngeal paraesthesia | 34.38 | 17.06 | 21 | 55936 | 1448 | 50547719 |
Hypoalbuminaemia | 34.06 | 17.06 | 48 | 55909 | 9812 | 50539355 |
Blister | 33.68 | 17.06 | 27 | 55930 | 85391 | 50463776 |
Injection site pruritus | 33.60 | 17.06 | 3 | 55954 | 40408 | 50508759 |
ECG signs of myocardial ischaemia | 33.39 | 17.06 | 9 | 55948 | 65 | 50549102 |
Migraine | 33.35 | 17.06 | 21 | 55936 | 75259 | 50473908 |
Mobility decreased | 33.15 | 17.06 | 24 | 55933 | 79924 | 50469243 |
Muscle spasms | 33.09 | 17.06 | 245 | 55712 | 125308 | 50423859 |
Metastases to spleen | 32.72 | 17.06 | 10 | 55947 | 118 | 50549049 |
Memory impairment | 32.67 | 17.06 | 24 | 55933 | 79336 | 50469831 |
Abortion spontaneous | 32.42 | 17.06 | 4 | 55953 | 41768 | 50507399 |
Incorrect dose administered | 32.31 | 17.06 | 7 | 55950 | 48407 | 50500760 |
Anastomotic fistula | 32.05 | 17.06 | 7 | 55950 | 17 | 50549150 |
Muscle rigidity | 31.25 | 17.06 | 46 | 55911 | 9783 | 50539384 |
Nicotinic acid deficiency | 31.24 | 17.06 | 8 | 55949 | 46 | 50549121 |
Myalgia | 31.24 | 17.06 | 56 | 55901 | 124263 | 50424904 |
Tumour ulceration | 31.16 | 17.06 | 10 | 55947 | 140 | 50549027 |
Motion sickness | 31.13 | 17.06 | 16 | 55941 | 788 | 50548379 |
Ocular toxicity | 30.64 | 17.06 | 14 | 55943 | 531 | 50548636 |
Vascular pain | 30.59 | 17.06 | 15 | 55942 | 668 | 50548499 |
Infection | 30.57 | 17.06 | 94 | 55863 | 172860 | 50376307 |
Catheter site bruise | 30.42 | 17.06 | 12 | 55945 | 314 | 50548853 |
Metastases to ovary | 29.60 | 17.06 | 12 | 55945 | 338 | 50548829 |
Metastasis | 29.59 | 17.06 | 30 | 55927 | 4345 | 50544822 |
Gastric perforation | 29.34 | 17.06 | 19 | 55938 | 1451 | 50547716 |
Paraphilia | 29.04 | 17.06 | 5 | 55952 | 0 | 50549167 |
Oropharyngeal discomfort | 28.95 | 17.06 | 28 | 55929 | 3830 | 50545337 |
Subileus | 28.56 | 17.06 | 24 | 55933 | 2735 | 50546432 |
Hemiparaesthesia | 28.53 | 17.06 | 8 | 55949 | 68 | 50549099 |
Perforation | 28.41 | 17.06 | 16 | 55941 | 948 | 50548219 |
Herpes zoster | 28.38 | 17.06 | 22 | 55935 | 70764 | 50478403 |
Pulmonary embolism | 28.25 | 17.06 | 201 | 55756 | 101503 | 50447664 |
Dysgeusia | 28.23 | 17.06 | 101 | 55856 | 38815 | 50510352 |
Wrong technique in product usage process | 28.22 | 17.06 | 13 | 55944 | 55497 | 50493670 |
Skin fissures | 28.18 | 17.06 | 41 | 55916 | 8627 | 50540540 |
Haemolysis | 28.13 | 17.06 | 34 | 55923 | 5982 | 50543185 |
Inappropriate schedule of product administration | 27.95 | 17.06 | 23 | 55934 | 71808 | 50477359 |
Lip oedema | 27.47 | 17.06 | 25 | 55932 | 3168 | 50545999 |
Type 2 diabetes mellitus | 27.40 | 17.06 | 3 | 55954 | 34372 | 50514795 |
Tonic clonic movements | 27.21 | 17.06 | 17 | 55940 | 1220 | 50547947 |
Hemiparesis | 27.11 | 17.06 | 65 | 55892 | 19983 | 50529184 |
K-ras gene mutation | 27.07 | 17.06 | 6 | 55951 | 16 | 50549151 |
Left ventricular failure | 27.07 | 17.06 | 30 | 55927 | 4811 | 50544356 |
Metastases to lymph nodes | 26.99 | 17.06 | 36 | 55921 | 6988 | 50542179 |
Inferior vena cava stenosis | 26.81 | 17.06 | 6 | 55951 | 17 | 50549150 |
Sleep disorder | 26.76 | 17.06 | 15 | 55942 | 57268 | 50491899 |
Medical device site extravasation | 26.70 | 17.06 | 5 | 55952 | 3 | 50549164 |
Cholangitis | 26.68 | 17.06 | 29 | 55928 | 4550 | 50544617 |
Tumour necrosis | 26.68 | 17.06 | 14 | 55943 | 720 | 50548447 |
Trismus | 26.46 | 17.06 | 25 | 55932 | 3323 | 50545844 |
Hypophagia | 26.45 | 17.06 | 79 | 55878 | 27649 | 50521518 |
Blood pressure fluctuation | 26.45 | 17.06 | 4 | 55953 | 35819 | 50513348 |
Cardiospasm | 26.31 | 17.06 | 6 | 55951 | 19 | 50549148 |
Feeling abnormal | 26.07 | 17.06 | 63 | 55894 | 125429 | 50423738 |
Palmar erythema | 25.91 | 17.06 | 18 | 55939 | 1545 | 50547622 |
White blood cell count abnormal | 25.85 | 17.06 | 31 | 55926 | 5409 | 50543758 |
Gastric varices haemorrhage | 25.61 | 17.06 | 8 | 55949 | 102 | 50549065 |
Schistosomiasis | 25.58 | 17.06 | 5 | 55952 | 5 | 50549162 |
Haematemesis | 25.52 | 17.06 | 78 | 55879 | 27647 | 50521520 |
Gastrointestinal anastomotic leak | 25.36 | 17.06 | 9 | 55948 | 174 | 50548993 |
Rhabdomyolysis | 25.33 | 17.06 | 6 | 55951 | 39021 | 50510146 |
Catabolic state | 25.23 | 17.06 | 7 | 55950 | 57 | 50549110 |
Type I hypersensitivity | 25.21 | 17.06 | 21 | 55936 | 2364 | 50546803 |
Urinary tract infection | 25.15 | 17.06 | 145 | 55812 | 223875 | 50325292 |
Peripheral motor neuropathy | 24.95 | 17.06 | 17 | 55940 | 1414 | 50547753 |
Metastases to bone marrow | 24.92 | 17.06 | 10 | 55947 | 274 | 50548893 |
Aortic intramural haematoma | 24.81 | 17.06 | 7 | 55950 | 61 | 50549106 |
Soft tissue necrosis | 24.72 | 17.06 | 11 | 55946 | 392 | 50548775 |
Monoparesis | 24.60 | 17.06 | 17 | 55940 | 1447 | 50547720 |
Myopathy toxic | 24.56 | 17.06 | 11 | 55946 | 398 | 50548769 |
Hyperpyrexia | 24.54 | 17.06 | 23 | 55934 | 3026 | 50546141 |
Influenza like illness | 24.14 | 17.06 | 17 | 55940 | 57442 | 50491725 |
Administration site extravasation | 24.09 | 17.06 | 13 | 55944 | 708 | 50548459 |
Dizziness | 24.01 | 17.06 | 256 | 55701 | 346113 | 50203054 |
Metastases to diaphragm | 23.97 | 17.06 | 6 | 55951 | 31 | 50549136 |
Hepatocellular injury | 23.88 | 17.06 | 73 | 55884 | 25874 | 50523293 |
Hepatic function abnormal | 23.86 | 17.06 | 85 | 55872 | 32596 | 50516571 |
Inflammation | 23.70 | 17.06 | 17 | 55940 | 56895 | 50492272 |
Folliculitis | 23.62 | 17.06 | 7 | 55950 | 39218 | 50509949 |
Type II hypersensitivity | 23.56 | 17.06 | 5 | 55952 | 10 | 50549157 |
Skin reaction | 23.16 | 17.06 | 44 | 55913 | 11524 | 50537643 |
Treatment noncompliance | 23.12 | 17.06 | 3 | 55954 | 30147 | 50519020 |
Hypocapnia | 22.93 | 17.06 | 10 | 55947 | 339 | 50548828 |
Productive cough | 22.93 | 17.06 | 15 | 55942 | 52679 | 50496488 |
Cyanosis | 22.46 | 17.06 | 51 | 55906 | 15133 | 50534034 |
Portal shunt | 22.38 | 17.06 | 5 | 55952 | 14 | 50549153 |
Implant site dehiscence | 22.38 | 17.06 | 5 | 55952 | 14 | 50549153 |
Subacute cutaneous lupus erythematosus | 22.38 | 17.06 | 19 | 55938 | 2196 | 50546971 |
Oesophageal varices haemorrhage | 22.27 | 17.06 | 14 | 55943 | 1016 | 50548151 |
Chest discomfort | 22.22 | 17.06 | 177 | 55780 | 92545 | 50456622 |
Colon cancer metastatic | 22.14 | 17.06 | 14 | 55943 | 1026 | 50548141 |
COVID-19 | 22.11 | 17.06 | 12 | 55945 | 46650 | 50502517 |
Loss of personal independence in daily activities | 22.03 | 17.06 | 27 | 55930 | 70023 | 50479144 |
Gastrointestinal stoma complication | 21.83 | 17.06 | 16 | 55941 | 1494 | 50547673 |
Rectal cancer recurrent | 21.65 | 17.06 | 5 | 55952 | 17 | 50549150 |
Small intestinal obstruction | 21.62 | 17.06 | 52 | 55905 | 16016 | 50533151 |
Haemolytic uraemic syndrome | 21.62 | 17.06 | 19 | 55938 | 2300 | 50546867 |
Unevaluable event | 21.60 | 17.06 | 12 | 55945 | 46054 | 50503113 |
Hypotension | 21.57 | 17.06 | 373 | 55584 | 235096 | 50314071 |
Sedation | 21.31 | 17.06 | 4 | 55953 | 30606 | 50518561 |
Hyperventilation | 21.21 | 17.06 | 28 | 55929 | 5381 | 50543786 |
Eyelid ptosis | 21.19 | 17.06 | 30 | 55927 | 6157 | 50543010 |
Respiratory distress | 21.16 | 17.06 | 78 | 55879 | 30411 | 50518756 |
Adverse drug reaction | 21.09 | 17.06 | 18 | 55939 | 55204 | 50493963 |
Infusion related reaction | 21.09 | 17.06 | 283 | 55674 | 169274 | 50379893 |
Respiratory fatigue | 21.01 | 17.06 | 7 | 55950 | 111 | 50549056 |
Lacrimation disorder | 21.00 | 17.06 | 4 | 55953 | 3 | 50549164 |
Hepatic encephalopathy | 20.98 | 17.06 | 38 | 55919 | 9598 | 50539569 |
Blood glucose increased | 20.88 | 17.06 | 29 | 55928 | 71295 | 50477872 |
Renal tubular disorder | 20.81 | 17.06 | 19 | 55938 | 2418 | 50546749 |
Impaired healing | 20.80 | 17.06 | 28 | 55929 | 69758 | 50479409 |
Toxic encephalopathy | 20.78 | 17.06 | 28 | 55929 | 5487 | 50543680 |
Ileus paralytic | 20.77 | 17.06 | 24 | 55933 | 4026 | 50545141 |
Biliary tract infection | 20.72 | 17.06 | 10 | 55947 | 430 | 50548737 |
Dyslalia | 20.63 | 17.06 | 10 | 55947 | 434 | 50548733 |
Coronary artery disease | 20.45 | 17.06 | 4 | 55953 | 29722 | 50519445 |
Pelvic fluid collection | 20.42 | 17.06 | 12 | 55945 | 771 | 50548396 |
Balance disorder | 20.36 | 17.06 | 29 | 55928 | 70561 | 50478606 |
Nasal congestion | 20.35 | 17.06 | 16 | 55941 | 51104 | 50498063 |
Colitis ischaemic | 20.15 | 17.06 | 37 | 55920 | 9446 | 50539721 |
Granulocyte count decreased | 20.09 | 17.06 | 12 | 55945 | 794 | 50548373 |
Encapsulating peritoneal sclerosis | 20.01 | 17.06 | 9 | 55948 | 329 | 50548838 |
Confusional state | 19.99 | 17.06 | 122 | 55835 | 185806 | 50363361 |
Diabetes mellitus | 19.96 | 17.06 | 15 | 55942 | 49018 | 50500149 |
Portal vein dilatation | 19.95 | 17.06 | 5 | 55952 | 26 | 50549141 |
Paralysis | 19.93 | 17.06 | 35 | 55922 | 8629 | 50540538 |
Sputum abnormal | 19.85 | 17.06 | 10 | 55947 | 472 | 50548695 |
Colorectal cancer recurrent | 19.58 | 17.06 | 4 | 55953 | 6 | 50549161 |
Rhinorrhoea | 19.47 | 17.06 | 17 | 55940 | 51566 | 50497601 |
Heart rate decreased | 19.42 | 17.06 | 8 | 55949 | 36489 | 50512678 |
Oral dysaesthesia | 19.39 | 17.06 | 6 | 55951 | 74 | 50549093 |
Subclavian vein thrombosis | 19.35 | 17.06 | 16 | 55941 | 1783 | 50547384 |
Drug reaction with eosinophilia and systemic symptoms | 19.19 | 17.06 | 4 | 55953 | 28420 | 50520747 |
Hyperlipasaemia | 19.10 | 17.06 | 10 | 55947 | 512 | 50548655 |
Disease recurrence | 18.95 | 17.06 | 57 | 55900 | 20024 | 50529143 |
Hepatic vein stenosis | 18.94 | 17.06 | 5 | 55952 | 33 | 50549134 |
Dry eye | 18.83 | 17.06 | 6 | 55951 | 32089 | 50517078 |
Tongue discomfort | 18.82 | 17.06 | 16 | 55941 | 1852 | 50547315 |
Aortic dissection | 18.81 | 17.06 | 15 | 55942 | 1588 | 50547579 |
Hereditary motor and sensory neuropathy | 18.76 | 17.06 | 6 | 55951 | 83 | 50549084 |
Viral infection | 18.71 | 17.06 | 5 | 55952 | 29981 | 50519186 |
Gastrooesophageal reflux disease | 18.68 | 17.06 | 35 | 55922 | 76393 | 50472774 |
Hyperbilirubinaemia | 18.67 | 17.06 | 36 | 55921 | 9534 | 50539633 |
Red cell fragmentation syndrome | 18.56 | 17.06 | 5 | 55952 | 36 | 50549131 |
Peripheral nerve injury | 18.52 | 17.06 | 9 | 55948 | 393 | 50548774 |
Hypervolaemia | 18.48 | 17.06 | 3 | 55954 | 25496 | 50523671 |
Encephalopathy | 18.39 | 17.06 | 80 | 55877 | 33631 | 50515536 |
Stoma site haemorrhage | 18.38 | 17.06 | 12 | 55945 | 929 | 50548238 |
Diaphragmatic paralysis | 18.36 | 17.06 | 10 | 55947 | 555 | 50548612 |
Hypersensitivity | 18.34 | 17.06 | 337 | 55620 | 214824 | 50334343 |
Gastrointestinal inflammation | 18.33 | 17.06 | 24 | 55933 | 4576 | 50544591 |
Adverse event | 18.32 | 17.06 | 13 | 55944 | 43750 | 50505417 |
Trichomegaly | 17.99 | 17.06 | 5 | 55952 | 41 | 50549126 |
Jaw operation | 17.87 | 17.06 | 11 | 55946 | 769 | 50548398 |
Aortic thrombosis | 17.84 | 17.06 | 12 | 55945 | 977 | 50548190 |
Congestive cardiomyopathy | 17.79 | 17.06 | 26 | 55931 | 5492 | 50543675 |
Duodenal ulcer | 17.75 | 17.06 | 29 | 55928 | 6746 | 50542421 |
Retching | 17.71 | 17.06 | 42 | 55915 | 12820 | 50536347 |
Endometrial dysplasia | 17.70 | 17.06 | 4 | 55953 | 12 | 50549155 |
Weight decreased | 17.63 | 17.06 | 158 | 55799 | 221087 | 50328080 |
Respiratory failure | 17.63 | 17.06 | 166 | 55791 | 91015 | 50458152 |
Appendicitis noninfective | 17.43 | 17.06 | 3 | 55954 | 0 | 50549167 |
Road traffic accident | 17.35 | 17.06 | 3 | 55954 | 24349 | 50524818 |
Hypothyroidism | 17.33 | 17.06 | 8 | 55949 | 34117 | 50515050 |
Femoral artery embolism | 17.29 | 17.06 | 5 | 55952 | 48 | 50549119 |
Acute respiratory distress syndrome | 17.26 | 17.06 | 57 | 55900 | 21042 | 50528125 |
Femur fracture | 17.22 | 17.06 | 10 | 55947 | 37454 | 50511713 |
Gastrointestinal stoma output increased | 17.21 | 17.06 | 7 | 55950 | 199 | 50548968 |
Pneumatosis intestinalis | 17.19 | 17.06 | 16 | 55941 | 2087 | 50547080 |
Pigmentation disorder | 17.15 | 17.06 | 21 | 55936 | 3743 | 50545424 |
Embolism | 17.15 | 17.06 | 29 | 55928 | 6939 | 50542228 |
Surgery | 17.11 | 17.06 | 6 | 55951 | 30199 | 50518968 |
Pulmonary artery thrombosis | 17.09 | 17.06 | 10 | 55947 | 637 | 50548530 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neuropathy peripheral | 1212.37 | 15.09 | 1190 | 76164 | 69837 | 29427336 |
Disease progression | 661.72 | 15.09 | 936 | 76418 | 80980 | 29416193 |
Neurotoxicity | 635.48 | 15.09 | 424 | 76930 | 14189 | 29482984 |
Diarrhoea | 628.39 | 15.09 | 2098 | 75256 | 330600 | 29166573 |
Neutropenia | 602.08 | 15.09 | 1164 | 76190 | 130547 | 29366626 |
Palmar-plantar erythrodysaesthesia syndrome | 558.36 | 15.09 | 393 | 76961 | 14366 | 29482807 |
Dermatitis acneiform | 536.92 | 15.09 | 270 | 77084 | 5221 | 29491952 |
Skin toxicity | 485.67 | 15.09 | 224 | 77130 | 3547 | 29493626 |
Thrombocytopenia | 453.67 | 15.09 | 1052 | 76302 | 133771 | 29363402 |
Arteriospasm coronary | 448.86 | 15.09 | 189 | 77165 | 2376 | 29494797 |
Paronychia | 329.78 | 15.09 | 159 | 77195 | 2794 | 29494379 |
Vomiting | 327.78 | 15.09 | 1256 | 76098 | 211004 | 29286169 |
Erythema | 317.78 | 15.09 | 646 | 76708 | 74960 | 29422213 |
Metastases to liver | 315.72 | 15.09 | 256 | 77098 | 11600 | 29485573 |
Interstitial lung disease | 311.78 | 15.09 | 549 | 76805 | 57169 | 29440004 |
Peripheral sensory neuropathy | 284.08 | 15.09 | 183 | 77171 | 5756 | 29491417 |
Paraesthesia | 279.01 | 15.09 | 503 | 76851 | 53342 | 29443831 |
Nausea | 277.18 | 15.09 | 1486 | 75868 | 287769 | 29209404 |
Venoocclusive liver disease | 258.73 | 15.09 | 183 | 77171 | 6734 | 29490439 |
Mucosal inflammation | 255.88 | 15.09 | 362 | 76992 | 31233 | 29465940 |
Gastrointestinal perforation | 238.16 | 15.09 | 135 | 77219 | 3348 | 29493825 |
Polyneuropathy | 237.64 | 15.09 | 220 | 77134 | 11932 | 29485241 |
Drug ineffective | 235.14 | 15.09 | 368 | 76986 | 362802 | 29134371 |
Portal hypertension | 232.67 | 15.09 | 133 | 77221 | 3353 | 29493820 |
Bone marrow failure | 231.94 | 15.09 | 321 | 77033 | 27128 | 29470045 |
Myelosuppression | 221.18 | 15.09 | 212 | 77142 | 12015 | 29485158 |
Chills | 220.36 | 15.09 | 539 | 76815 | 70761 | 29426412 |
Completed suicide | 220.30 | 15.09 | 3 | 77351 | 90243 | 29406930 |
Product dose omission issue | 213.49 | 15.09 | 9 | 77345 | 96374 | 29400799 |
Hypersensitivity | 196.48 | 15.09 | 430 | 76924 | 52473 | 29444700 |
Arthralgia | 193.83 | 15.09 | 62 | 77292 | 139555 | 29357618 |
Stomatitis | 193.79 | 15.09 | 348 | 77006 | 36765 | 29460408 |
Haematotoxicity | 191.87 | 15.09 | 151 | 77203 | 6548 | 29490625 |
Enteritis | 183.65 | 15.09 | 148 | 77206 | 6643 | 29490530 |
Fall | 170.18 | 15.09 | 129 | 77225 | 177049 | 29320124 |
Metastases to lung | 166.87 | 15.09 | 149 | 77205 | 7706 | 29489467 |
Gastrointestinal toxicity | 165.98 | 15.09 | 90 | 77264 | 2041 | 29495132 |
Drug interaction | 165.01 | 15.09 | 164 | 77190 | 197221 | 29299952 |
Laryngospasm | 157.91 | 15.09 | 74 | 77280 | 1216 | 29495957 |
Bronchospasm | 152.23 | 15.09 | 155 | 77199 | 9454 | 29487719 |
Abdominal pain | 148.15 | 15.09 | 723 | 76631 | 134634 | 29362539 |
Headache | 144.89 | 15.09 | 145 | 77209 | 173862 | 29323311 |
Hyperammonaemic encephalopathy | 141.11 | 15.09 | 79 | 77275 | 1911 | 29495262 |
Flushing | 140.14 | 15.09 | 263 | 77091 | 28729 | 29468444 |
Overdose | 139.77 | 15.09 | 21 | 77333 | 79798 | 29417375 |
Focal nodular hyperplasia | 139.51 | 15.09 | 39 | 77315 | 116 | 29497057 |
Pneumonia | 136.53 | 15.09 | 409 | 76945 | 319763 | 29177410 |
Decreased appetite | 133.89 | 15.09 | 740 | 76614 | 144602 | 29352571 |
Cardiotoxicity | 131.70 | 15.09 | 105 | 77249 | 4639 | 29492534 |
Carcinoembryonic antigen increased | 129.64 | 15.09 | 52 | 77302 | 572 | 29496601 |
Dysaesthesia pharynx | 122.52 | 15.09 | 29 | 77325 | 31 | 29497142 |
Feeling hot | 121.69 | 15.09 | 175 | 77179 | 15313 | 29481860 |
Proteinuria | 117.54 | 15.09 | 174 | 77180 | 15630 | 29481543 |
Hyperammonaemia | 117.47 | 15.09 | 106 | 77248 | 5557 | 29491616 |
Hypomagnesaemia | 116.75 | 15.09 | 183 | 77171 | 17285 | 29479888 |
Neutrophil count decreased | 107.50 | 15.09 | 303 | 77051 | 43264 | 29453909 |
Cardiac failure congestive | 106.18 | 15.09 | 34 | 77320 | 76547 | 29420626 |
Leukopenia | 104.56 | 15.09 | 350 | 77004 | 54853 | 29442320 |
Skin reaction | 104.30 | 15.09 | 89 | 77265 | 4328 | 29492845 |
Infusion related reaction | 104.19 | 15.09 | 301 | 77053 | 43585 | 29453588 |
Dehydration | 104.08 | 15.09 | 582 | 76772 | 114166 | 29383007 |
Intravascular haemolysis | 102.05 | 15.09 | 39 | 77315 | 373 | 29496800 |
Pyrexia | 100.59 | 15.09 | 1171 | 76183 | 286451 | 29210722 |
Ascites | 98.62 | 15.09 | 263 | 77091 | 36356 | 29460817 |
Intestinal obstruction | 98.32 | 15.09 | 179 | 77175 | 19098 | 29478075 |
Depression | 96.72 | 15.09 | 51 | 77303 | 85096 | 29412077 |
Insomnia | 93.91 | 15.09 | 58 | 77296 | 88703 | 29408470 |
Oxygen saturation decreased | 92.37 | 15.09 | 293 | 77061 | 44644 | 29452529 |
Therapy partial responder | 91.84 | 15.09 | 89 | 77265 | 5110 | 29492063 |
Anastomotic leak | 88.13 | 15.09 | 39 | 77315 | 557 | 29496616 |
Varices oesophageal | 88.12 | 15.09 | 70 | 77284 | 3076 | 29494097 |
Hospitalisation | 88.03 | 15.09 | 9 | 77345 | 45979 | 29451194 |
Anastomotic complication | 86.31 | 15.09 | 33 | 77321 | 316 | 29496857 |
Anxiety | 85.93 | 15.09 | 59 | 77295 | 85306 | 29411867 |
Myalgia | 84.56 | 15.09 | 44 | 77310 | 73975 | 29423198 |
Metastases to peritoneum | 83.12 | 15.09 | 51 | 77303 | 1469 | 29495704 |
Somnolence | 83.12 | 15.09 | 74 | 77280 | 93881 | 29403292 |
Ileus | 82.85 | 15.09 | 141 | 77213 | 14261 | 29482912 |
Anaphylactic shock | 82.65 | 15.09 | 135 | 77219 | 13201 | 29483972 |
Tumour perforation | 80.41 | 15.09 | 29 | 77325 | 232 | 29496941 |
Joint swelling | 80.40 | 15.09 | 16 | 77338 | 49614 | 29447559 |
Peripheral swelling | 78.77 | 15.09 | 34 | 77320 | 63705 | 29433468 |
Aggression | 76.43 | 15.09 | 4 | 77350 | 35537 | 29461636 |
Rhabdomyolysis | 75.84 | 15.09 | 32 | 77322 | 60776 | 29436397 |
Weight increased | 74.52 | 15.09 | 55 | 77299 | 76612 | 29420561 |
Confusional state | 73.67 | 15.09 | 139 | 77215 | 127738 | 29369435 |
Malignant neoplasm progression | 73.23 | 15.09 | 384 | 76970 | 73475 | 29423698 |
Enterocolitis | 71.93 | 15.09 | 88 | 77266 | 6578 | 29490595 |
Large intestine perforation | 69.68 | 15.09 | 91 | 77263 | 7265 | 29489908 |
Type I hypersensitivity | 69.13 | 15.09 | 40 | 77314 | 1032 | 29496141 |
Diffuse large B-cell lymphoma recurrent | 68.94 | 15.09 | 56 | 77298 | 2541 | 29494632 |
Influenza | 68.90 | 15.09 | 13 | 77341 | 41868 | 29455305 |
Inappropriate schedule of product administration | 68.64 | 15.09 | 16 | 77338 | 44456 | 29452717 |
Peritonitis | 68.54 | 15.09 | 132 | 77222 | 14692 | 29482481 |
Portal shunt | 68.04 | 15.09 | 17 | 77337 | 27 | 29497146 |
Toxic leukoencephalopathy | 67.46 | 15.09 | 26 | 77328 | 255 | 29496918 |
Dihydropyrimidine dehydrogenase deficiency | 67.11 | 15.09 | 19 | 77335 | 60 | 29497113 |
Incorrect dose administered | 67.07 | 15.09 | 5 | 77349 | 32979 | 29464194 |
Pneumatosis intestinalis | 67.07 | 15.09 | 60 | 77294 | 3109 | 29494064 |
Tumour necrosis | 66.94 | 15.09 | 40 | 77314 | 1097 | 29496076 |
Extravasation | 66.63 | 15.09 | 46 | 77308 | 1626 | 29495547 |
Disseminated intravascular coagulation | 65.85 | 15.09 | 155 | 77199 | 19825 | 29477348 |
Injection site pain | 65.75 | 15.09 | 5 | 77349 | 32441 | 29464732 |
Vascular pain | 65.15 | 15.09 | 21 | 77333 | 114 | 29497059 |
Stomal varices | 64.58 | 15.09 | 17 | 77337 | 37 | 29497136 |
Hallucination | 63.48 | 15.09 | 19 | 77335 | 44693 | 29452480 |
Myocardial infarction | 63.41 | 15.09 | 120 | 77234 | 110176 | 29386997 |
Neoplasm progression | 63.10 | 15.09 | 146 | 77208 | 18466 | 29478707 |
Non-cirrhotic portal hypertension | 62.57 | 15.09 | 24 | 77330 | 232 | 29496941 |
Contusion | 62.42 | 15.09 | 5 | 77349 | 31090 | 29466083 |
Blood glucose increased | 61.73 | 15.09 | 39 | 77315 | 58945 | 29438228 |
Rectal perforation | 61.62 | 15.09 | 27 | 77327 | 376 | 29496797 |
Suicidal ideation | 61.04 | 15.09 | 9 | 77345 | 34707 | 29462466 |
Hepatic atrophy | 59.92 | 15.09 | 21 | 77333 | 153 | 29497020 |
Electrocardiogram QT prolonged | 59.90 | 15.09 | 11 | 77343 | 36126 | 29461047 |
Electrocardiogram ST segment elevation | 59.68 | 15.09 | 66 | 77288 | 4426 | 29492747 |
Product use issue | 59.60 | 15.09 | 30 | 77324 | 51414 | 29445759 |
Paraesthesia oral | 59.58 | 15.09 | 59 | 77295 | 3478 | 29493695 |
Pain in extremity | 59.32 | 15.09 | 125 | 77229 | 110308 | 29386865 |
Nodular regenerative hyperplasia | 59.26 | 15.09 | 31 | 77323 | 652 | 29496521 |
Hypertransaminasaemia | 58.62 | 15.09 | 59 | 77295 | 3547 | 29493626 |
Metastases to lymph nodes | 58.58 | 15.09 | 62 | 77292 | 3955 | 29493218 |
Memory impairment | 58.56 | 15.09 | 12 | 77342 | 36458 | 29460715 |
Death | 57.17 | 15.09 | 596 | 76758 | 341488 | 29155685 |
General physical health deterioration | 57.10 | 15.09 | 462 | 76892 | 102395 | 29394778 |
Foetal exposure during pregnancy | 56.81 | 15.09 | 10 | 77344 | 33857 | 29463316 |
Cholinergic syndrome | 56.79 | 15.09 | 27 | 77327 | 459 | 29496714 |
Intestinal perforation | 55.81 | 15.09 | 86 | 77268 | 8000 | 29489173 |
Colon cancer metastatic | 54.71 | 15.09 | 39 | 77315 | 1452 | 29495721 |
Necrotising fasciitis | 54.60 | 15.09 | 55 | 77299 | 3310 | 29493863 |
Laryngeal discomfort | 54.39 | 15.09 | 19 | 77335 | 137 | 29497036 |
Tumour lysis syndrome | 53.92 | 15.09 | 115 | 77239 | 13769 | 29483404 |
Coronary artery disease | 53.91 | 15.09 | 24 | 77330 | 44166 | 29453007 |
Dysphonia | 53.83 | 15.09 | 140 | 77214 | 19056 | 29478117 |
Hyperhidrosis | 53.62 | 15.09 | 320 | 77034 | 64220 | 29432953 |
Colorectal cancer metastatic | 53.11 | 15.09 | 27 | 77327 | 534 | 29496639 |
Administration site extravasation | 52.95 | 15.09 | 26 | 77328 | 476 | 29496697 |
Palmar erythema | 52.76 | 15.09 | 21 | 77333 | 226 | 29496947 |
Asthma | 52.59 | 15.09 | 12 | 77342 | 33837 | 29463336 |
Toxicity to various agents | 51.68 | 15.09 | 256 | 77098 | 173405 | 29323768 |
Pulmonary embolism | 51.63 | 15.09 | 360 | 76994 | 76174 | 29420999 |
Hiccups | 51.34 | 15.09 | 87 | 77267 | 8766 | 29488407 |
Agitation | 50.89 | 15.09 | 36 | 77318 | 51268 | 29445905 |
Rash pustular | 50.73 | 15.09 | 62 | 77292 | 4629 | 29492544 |
Feeling abnormal | 50.42 | 15.09 | 41 | 77313 | 54404 | 29442769 |
Splenomegaly | 49.29 | 15.09 | 108 | 77246 | 13171 | 29484002 |
Gastrointestinal anastomotic leak | 48.21 | 15.09 | 22 | 77332 | 339 | 29496834 |
Cholangitis | 47.65 | 15.09 | 77 | 77277 | 7460 | 29489713 |
Arthritis | 47.60 | 15.09 | 5 | 77349 | 25014 | 29472159 |
Stoma site haemorrhage | 46.89 | 15.09 | 27 | 77327 | 690 | 29496483 |
Therapeutic product effect decreased | 46.64 | 15.09 | 10 | 77344 | 29441 | 29467732 |
Unevaluable event | 45.55 | 15.09 | 11 | 77343 | 29840 | 29467333 |
Transdifferentiation of neoplasm | 45.41 | 15.09 | 14 | 77340 | 64 | 29497109 |
Drug reaction with eosinophilia and systemic symptoms | 45.38 | 15.09 | 9 | 77345 | 27983 | 29469190 |
Prinzmetal angina | 44.89 | 15.09 | 28 | 77326 | 831 | 29496342 |
Malignant ascites | 44.22 | 15.09 | 21 | 77333 | 356 | 29496817 |
Nasopharyngitis | 43.77 | 15.09 | 55 | 77299 | 59610 | 29437563 |
Treatment noncompliance | 43.25 | 15.09 | 6 | 77348 | 24221 | 29472952 |
Drug dependence | 43.18 | 15.09 | 3 | 77351 | 20978 | 29476195 |
Anastomotic fistula | 43.16 | 15.09 | 13 | 77341 | 54 | 29497119 |
Perforation | 43.12 | 15.09 | 17 | 77337 | 178 | 29496995 |
Cellulitis | 43.10 | 15.09 | 34 | 77320 | 45806 | 29451367 |
Asthenia | 42.68 | 15.09 | 795 | 76559 | 214455 | 29282718 |
Febrile neutropenia | 42.62 | 15.09 | 465 | 76889 | 111775 | 29385398 |
Enterovesical fistula | 42.48 | 15.09 | 24 | 77330 | 591 | 29496582 |
Temperature intolerance | 42.45 | 15.09 | 45 | 77309 | 2876 | 29494297 |
Evans syndrome | 42.19 | 15.09 | 18 | 77336 | 234 | 29496939 |
Periportal sinus dilatation | 42.09 | 15.09 | 11 | 77343 | 23 | 29497150 |
Intestinal ischaemia | 41.80 | 15.09 | 68 | 77286 | 6624 | 29490549 |
Throat tightness | 41.54 | 15.09 | 70 | 77284 | 7021 | 29490152 |
Nicotinic acid deficiency | 40.57 | 15.09 | 13 | 77341 | 69 | 29497104 |
Dizziness | 40.57 | 15.09 | 310 | 77044 | 189374 | 29307799 |
Septic shock | 40.27 | 15.09 | 291 | 77063 | 62269 | 29434904 |
Chronic obstructive pulmonary disease | 40.27 | 15.09 | 29 | 77325 | 40926 | 29456247 |
Subileus | 39.82 | 15.09 | 43 | 77311 | 2807 | 29494366 |
Large intestinal obstruction | 39.80 | 15.09 | 31 | 77323 | 1323 | 29495850 |
Oxygen saturation normal | 39.59 | 15.09 | 8 | 77346 | 0 | 29497173 |
Noninfective epididymitis | 39.59 | 15.09 | 8 | 77346 | 0 | 29497173 |
Hyperthermia | 38.82 | 15.09 | 80 | 77274 | 9350 | 29487823 |
Immune thrombocytopenia | 38.71 | 15.09 | 72 | 77282 | 7805 | 29489368 |
Pain | 38.65 | 15.09 | 276 | 77078 | 171156 | 29326017 |
Small intestinal obstruction | 38.42 | 15.09 | 97 | 77257 | 12964 | 29484209 |
Abnormal behaviour | 38.41 | 15.09 | 7 | 77347 | 23120 | 29474053 |
Blood pressure immeasurable | 38.19 | 15.09 | 25 | 77329 | 808 | 29496365 |
Dysaesthesia | 37.92 | 15.09 | 36 | 77318 | 2014 | 29495159 |
Drug level increased | 37.76 | 15.09 | 3 | 77351 | 18784 | 29478389 |
Off label use | 37.68 | 15.09 | 1041 | 76313 | 299759 | 29197414 |
Neutropenic sepsis | 37.58 | 15.09 | 90 | 77264 | 11637 | 29485536 |
Musculoskeletal stiffness | 37.52 | 15.09 | 26 | 77328 | 37432 | 29459741 |
Influenza like illness | 37.37 | 15.09 | 9 | 77345 | 24461 | 29472712 |
Sinusitis | 36.92 | 15.09 | 22 | 77332 | 34328 | 29462845 |
Chronic kidney disease | 36.84 | 15.09 | 25 | 77329 | 36391 | 29460782 |
Hypokalaemia | 36.73 | 15.09 | 241 | 77113 | 49962 | 29447211 |
Liver function test abnormal | 36.39 | 15.09 | 15 | 77339 | 28903 | 29468270 |
Hypoglycaemia | 36.05 | 15.09 | 44 | 77310 | 48302 | 29448871 |
Acute coronary syndrome | 35.69 | 15.09 | 91 | 77263 | 12234 | 29484939 |
International normalised ratio increased | 35.67 | 15.09 | 38 | 77316 | 44334 | 29452839 |
Diabetes mellitus | 35.64 | 15.09 | 31 | 77323 | 39800 | 29457373 |
Hepatic infarction | 35.44 | 15.09 | 15 | 77339 | 191 | 29496982 |
Fluid retention | 35.33 | 15.09 | 9 | 77345 | 23551 | 29473622 |
Stridor | 34.92 | 15.09 | 36 | 77318 | 2227 | 29494946 |
Acute abdomen | 34.86 | 15.09 | 32 | 77322 | 1715 | 29495458 |
Cardiac disorder | 34.57 | 15.09 | 28 | 77326 | 37235 | 29459938 |
Cytomegalovirus infection | 34.56 | 15.09 | 9 | 77345 | 23206 | 29473967 |
Tumour marker increased | 34.29 | 15.09 | 20 | 77334 | 524 | 29496649 |
Psychotic disorder | 34.15 | 15.09 | 6 | 77348 | 20348 | 29476825 |
Premature baby | 34.07 | 15.09 | 3 | 77351 | 17277 | 29479896 |
Splenorenal shunt | 34.07 | 15.09 | 8 | 77346 | 8 | 29497165 |
Wrong technique in product usage process | 33.96 | 15.09 | 20 | 77334 | 31408 | 29465765 |
Cyanosis | 33.48 | 15.09 | 84 | 77270 | 11183 | 29485990 |
Abdominal discomfort | 33.24 | 15.09 | 46 | 77308 | 47857 | 29449316 |
Blood pressure fluctuation | 33.09 | 15.09 | 6 | 77348 | 19888 | 29477285 |
Condition aggravated | 32.73 | 15.09 | 236 | 77118 | 146059 | 29351114 |
Bronchitis | 32.62 | 15.09 | 29 | 77325 | 36839 | 29460334 |
Blood creatine phosphokinase increased | 32.46 | 15.09 | 35 | 77319 | 40609 | 29456564 |
Performance status decreased | 32.07 | 15.09 | 44 | 77310 | 3683 | 29493490 |
Pelvic abscess | 31.92 | 15.09 | 23 | 77331 | 871 | 29496302 |
Hypoalbuminaemia | 31.85 | 15.09 | 78 | 77276 | 10227 | 29486946 |
Leukoencephalopathy | 31.70 | 15.09 | 44 | 77310 | 3723 | 29493450 |
Type II hypersensitivity | 31.65 | 15.09 | 9 | 77345 | 29 | 29497144 |
Contraindicated product administered | 31.50 | 15.09 | 5 | 77349 | 18261 | 29478912 |
Mobility decreased | 31.44 | 15.09 | 14 | 77340 | 25766 | 29471407 |
Seizure | 31.41 | 15.09 | 131 | 77223 | 92992 | 29404181 |
Herpes zoster | 31.25 | 15.09 | 20 | 77334 | 30032 | 29467141 |
Portal venous gas | 30.95 | 15.09 | 16 | 77338 | 328 | 29496845 |
Haematoma | 30.94 | 15.09 | 11 | 77343 | 23201 | 29473972 |
Oesophageal haemorrhage | 30.90 | 15.09 | 25 | 77329 | 1128 | 29496045 |
Pulmonary fibrosis | 30.54 | 15.09 | 100 | 77254 | 15482 | 29481691 |
Metastasis | 30.29 | 15.09 | 41 | 77313 | 3388 | 29493785 |
Right ventricular ejection fraction decreased | 30.15 | 15.09 | 9 | 77345 | 36 | 29497137 |
Alopecia | 30.09 | 15.09 | 114 | 77240 | 18970 | 29478203 |
Hyperaemia | 29.95 | 15.09 | 23 | 77331 | 961 | 29496212 |
Haemolytic anaemia | 29.87 | 15.09 | 72 | 77282 | 9347 | 29487826 |
Hypervolaemia | 29.82 | 15.09 | 5 | 77349 | 17540 | 29479633 |
Biliary fistula | 29.76 | 15.09 | 9 | 77345 | 38 | 29497135 |
Sciatic nerve palsy | 29.76 | 15.09 | 9 | 77345 | 38 | 29497135 |
Carbohydrate antigen 19-9 increased | 29.74 | 15.09 | 13 | 77341 | 180 | 29496993 |
Oesophageal varices haemorrhage | 29.68 | 15.09 | 36 | 77318 | 2666 | 29494507 |
Hepatectomy | 29.51 | 15.09 | 10 | 77344 | 65 | 29497108 |
Recall phenomenon | 29.38 | 15.09 | 18 | 77336 | 517 | 29496656 |
Hypertensive crisis | 29.32 | 15.09 | 64 | 77290 | 7784 | 29489389 |
Cerebrovascular accident | 29.28 | 15.09 | 103 | 77251 | 76808 | 29420365 |
Lymphangiosis carcinomatosa | 29.24 | 15.09 | 21 | 77333 | 791 | 29496382 |
Perforation bile duct | 29.08 | 15.09 | 8 | 77346 | 22 | 29497151 |
Blood alkaline phosphatase abnormal | 28.99 | 15.09 | 16 | 77338 | 376 | 29496797 |
Failure to anastomose | 28.39 | 15.09 | 13 | 77341 | 202 | 29496971 |
Acute respiratory distress syndrome | 28.27 | 15.09 | 127 | 77227 | 22808 | 29474365 |
Encapsulating peritoneal sclerosis | 28.02 | 15.09 | 18 | 77336 | 563 | 29496610 |
Hypovolaemic shock | 27.98 | 15.09 | 54 | 77300 | 6018 | 29491155 |
Accidental overdose | 27.80 | 15.09 | 6 | 77348 | 17587 | 29479586 |
Haemoglobinuria | 27.79 | 15.09 | 18 | 77336 | 571 | 29496602 |
Device related infection | 27.69 | 15.09 | 97 | 77257 | 15539 | 29481634 |
Hyperbilirubinaemia | 27.63 | 15.09 | 94 | 77260 | 14840 | 29482333 |
Haemorrhage intracranial | 27.42 | 15.09 | 3 | 77351 | 14539 | 29482634 |
Sedation | 27.38 | 15.09 | 6 | 77348 | 17399 | 29479774 |
Anal sphincter atony | 27.30 | 15.09 | 10 | 77344 | 84 | 29497089 |
Necrotising oesophagitis | 27.24 | 15.09 | 17 | 77337 | 505 | 29496668 |
Subdural haematoma | 27.18 | 15.09 | 7 | 77347 | 18186 | 29478987 |
Delirium | 27.17 | 15.09 | 38 | 77316 | 39359 | 29457814 |
Gastric perforation | 27.13 | 15.09 | 31 | 77323 | 2155 | 29495018 |
Brain teratoma | 26.99 | 15.09 | 7 | 77347 | 14 | 29497159 |
Pulmonary toxicity | 26.97 | 15.09 | 47 | 77307 | 4843 | 29492330 |
Portal vein thrombosis | 26.88 | 15.09 | 38 | 77316 | 3271 | 29493902 |
Ocular toxicity | 26.77 | 15.09 | 12 | 77342 | 177 | 29496996 |
ECG signs of myocardial ischaemia | 26.53 | 15.09 | 12 | 77342 | 181 | 29496992 |
Muscular weakness | 26.47 | 15.09 | 79 | 77275 | 61973 | 29435200 |
Head injury | 26.42 | 15.09 | 5 | 77349 | 16076 | 29481097 |
Anaphylactic reaction | 26.36 | 15.09 | 142 | 77212 | 27431 | 29469742 |
Cachexia | 26.29 | 15.09 | 54 | 77300 | 6295 | 29490878 |
Pseudocirrhosis | 26.06 | 15.09 | 7 | 77347 | 17 | 29497156 |
Emotional distress | 25.87 | 15.09 | 3 | 77351 | 13892 | 29483281 |
Pruritus | 25.72 | 15.09 | 439 | 76915 | 116410 | 29380763 |
Localised infection | 25.68 | 15.09 | 3 | 77351 | 13813 | 29483360 |
Oesophagitis | 25.63 | 15.09 | 79 | 77275 | 11844 | 29485329 |
Vocal cord paralysis | 25.59 | 15.09 | 20 | 77334 | 858 | 29496315 |
Hyperkalaemia | 25.58 | 15.09 | 79 | 77275 | 61313 | 29435860 |
Osteomyelitis | 25.42 | 15.09 | 3 | 77351 | 13706 | 29483467 |
Blood cholesterol increased | 25.30 | 15.09 | 5 | 77349 | 15590 | 29481583 |
Medication error | 25.12 | 15.09 | 12 | 77342 | 21199 | 29475974 |
Nasal congestion | 25.07 | 15.09 | 9 | 77345 | 18870 | 29478303 |
Wound dehiscence | 25.03 | 15.09 | 35 | 77319 | 2982 | 29494191 |
Ileal perforation | 24.70 | 15.09 | 18 | 77336 | 694 | 29496479 |
Pulmonary artery thrombosis | 24.69 | 15.09 | 17 | 77337 | 598 | 29496575 |
Throat irritation | 24.55 | 15.09 | 64 | 77290 | 8721 | 29488452 |
Dyspnoea | 24.52 | 15.09 | 1066 | 76288 | 325666 | 29171507 |
Swelling | 24.36 | 15.09 | 34 | 77320 | 35249 | 29461924 |
Basal cell carcinoma | 24.33 | 15.09 | 7 | 77347 | 16903 | 29480270 |
Nephrotic syndrome | 24.09 | 15.09 | 52 | 77302 | 6276 | 29490897 |
Papilloedema | 24.02 | 15.09 | 30 | 77324 | 2290 | 29494883 |
Full blood count abnormal | 23.97 | 15.09 | 5 | 77349 | 15008 | 29482165 |
Koebner phenomenon | 23.87 | 15.09 | 8 | 77346 | 50 | 29497123 |
Blood creatinine increased | 23.83 | 15.09 | 128 | 77226 | 84974 | 29412199 |
Perihepatic abscess | 23.65 | 15.09 | 9 | 77345 | 85 | 29497088 |
Adverse drug reaction | 23.62 | 15.09 | 17 | 77337 | 24003 | 29473170 |
Cardiac ventricular disorder | 23.62 | 15.09 | 12 | 77342 | 237 | 29496936 |
Upper respiratory tract infection | 23.61 | 15.09 | 22 | 77332 | 27327 | 29469846 |
Renal disorder | 23.54 | 15.09 | 15 | 77339 | 22580 | 29474593 |
Fistula of small intestine | 23.53 | 15.09 | 14 | 77340 | 381 | 29496792 |
Pachymeningitis | 23.37 | 15.09 | 9 | 77345 | 88 | 29497085 |
Road traffic accident | 23.22 | 15.09 | 6 | 77348 | 15555 | 29481618 |
Erectile dysfunction | 23.22 | 15.09 | 9 | 77345 | 18000 | 29479173 |
Anaphylactoid reaction | 23.16 | 15.09 | 27 | 77327 | 1918 | 29495255 |
Product prescribing error | 23.15 | 15.09 | 9 | 77345 | 17967 | 29479206 |
Biliary tract infection | 23.13 | 15.09 | 15 | 77339 | 477 | 29496696 |
Gait disturbance | 23.01 | 15.09 | 106 | 77248 | 73243 | 29423930 |
Rectal cancer metastatic | 22.92 | 15.09 | 11 | 77343 | 191 | 29496982 |
Productive cough | 22.72 | 15.09 | 29 | 77325 | 31230 | 29465943 |
COVID-19 | 22.64 | 15.09 | 37 | 77317 | 35977 | 29461196 |
Hyperpyrexia | 22.53 | 15.09 | 29 | 77325 | 2281 | 29494892 |
Blood pressure systolic increased | 22.42 | 15.09 | 8 | 77346 | 16837 | 29480336 |
Pelvic fluid collection | 22.36 | 15.09 | 9 | 77345 | 100 | 29497073 |
Nephrolithiasis | 22.32 | 15.09 | 20 | 77334 | 25314 | 29471859 |
Muscle contractions involuntary | 22.30 | 15.09 | 25 | 77329 | 1702 | 29495471 |
Intestinal dilatation | 22.29 | 15.09 | 20 | 77334 | 1040 | 29496133 |
Oesophagobronchial fistula | 22.28 | 15.09 | 10 | 77344 | 148 | 29497025 |
Hepatic failure | 22.27 | 15.09 | 150 | 77204 | 31362 | 29465811 |
Cerebral vasoconstriction | 22.22 | 15.09 | 11 | 77343 | 205 | 29496968 |
Interventricular septum rupture | 22.22 | 15.09 | 6 | 77348 | 15 | 29497158 |
Embolism | 22.17 | 15.09 | 53 | 77301 | 6843 | 29490330 |
Skin fissures | 22.05 | 15.09 | 38 | 77316 | 3881 | 29493292 |
Metastases to muscle | 21.99 | 15.09 | 11 | 77343 | 210 | 29496963 |
Toxic epidermal necrolysis | 21.91 | 15.09 | 10 | 77344 | 18143 | 29479030 |
Fingerprint loss | 21.87 | 15.09 | 7 | 77347 | 37 | 29497136 |
Cholestasis | 21.86 | 15.09 | 120 | 77234 | 23342 | 29473831 |
Laryngeal oedema | 21.85 | 15.09 | 33 | 77321 | 3015 | 29494158 |
Metastases to retroperitoneum | 21.71 | 15.09 | 11 | 77343 | 216 | 29496957 |
Jaundice | 21.64 | 15.09 | 141 | 77213 | 29155 | 29468018 |
Pulmonary oedema | 21.58 | 15.09 | 50 | 77304 | 42685 | 29454488 |
Obstruction gastric | 21.50 | 15.09 | 18 | 77336 | 852 | 29496321 |
Oropharyngeal pain | 21.46 | 15.09 | 27 | 77327 | 29258 | 29467915 |
Induration | 21.40 | 15.09 | 18 | 77336 | 858 | 29496315 |
Eosinophilia | 21.38 | 15.09 | 16 | 77338 | 22145 | 29475028 |
Gastric dilatation | 21.29 | 15.09 | 15 | 77339 | 548 | 29496625 |
Hyperfibrinolysis | 21.18 | 15.09 | 6 | 77348 | 19 | 29497154 |
Drug intolerance | 21.06 | 15.09 | 61 | 77293 | 48318 | 29448855 |
Underdose | 21.04 | 15.09 | 3 | 77351 | 11866 | 29485307 |
Chronic myeloid leukaemia | 20.99 | 15.09 | 26 | 77328 | 1968 | 29495205 |
Shock | 20.98 | 15.09 | 111 | 77243 | 21293 | 29475880 |
Sarcoidosis | 20.98 | 15.09 | 30 | 77324 | 2610 | 29494563 |
Liver abscess | 20.96 | 15.09 | 34 | 77320 | 3304 | 29493869 |
Aortic thrombosis | 20.91 | 15.09 | 16 | 77338 | 665 | 29496508 |
Monocytopenia | 20.89 | 15.09 | 8 | 77346 | 77 | 29497096 |
Folliculitis | 20.88 | 15.09 | 37 | 77317 | 3863 | 29493310 |
Portal vein dilatation | 20.82 | 15.09 | 5 | 77349 | 6 | 29497167 |
Hypersplenism | 20.65 | 15.09 | 12 | 77342 | 312 | 29496861 |
Full blood count decreased | 20.60 | 15.09 | 8 | 77346 | 15984 | 29481189 |
Laboratory test abnormal | 20.47 | 15.09 | 11 | 77343 | 18174 | 29478999 |
Trismus | 20.39 | 15.09 | 28 | 77326 | 2345 | 29494828 |
Cold sweat | 20.34 | 15.09 | 60 | 77294 | 8782 | 29488391 |
Catheter site extravasation | 20.27 | 15.09 | 8 | 77346 | 84 | 29497089 |
Acral peeling skin syndrome | 20.22 | 15.09 | 7 | 77347 | 49 | 29497124 |
Allodynia | 20.14 | 15.09 | 15 | 77339 | 598 | 29496575 |
Mucosal toxicity | 20.08 | 15.09 | 10 | 77344 | 189 | 29496984 |
Small intestinal perforation | 20.01 | 15.09 | 23 | 77331 | 1609 | 29495564 |
Hypercreatinaemia | 19.94 | 15.09 | 9 | 77345 | 135 | 29497038 |
Band sensation | 19.86 | 15.09 | 8 | 77346 | 89 | 29497084 |
Feeling cold | 19.85 | 15.09 | 61 | 77293 | 9130 | 29488043 |
Respiratory arrest | 19.80 | 15.09 | 23 | 77331 | 25810 | 29471363 |
Pneumonitis chemical | 19.70 | 15.09 | 9 | 77345 | 139 | 29497034 |
Injection site erythema | 19.68 | 15.09 | 6 | 77348 | 13950 | 29483223 |
Hand-foot-genital syndrome | 19.62 | 15.09 | 5 | 77349 | 9 | 29497164 |
Hot flush | 19.59 | 15.09 | 84 | 77270 | 14786 | 29482387 |
Pneumonitis | 19.52 | 15.09 | 133 | 77221 | 27911 | 29469262 |
Labelled drug-drug interaction medication error | 19.52 | 15.09 | 4 | 77350 | 12155 | 29485018 |
Peripheral ischaemia | 19.41 | 15.09 | 42 | 77312 | 5077 | 29492096 |
Gout | 19.37 | 15.09 | 10 | 77344 | 16901 | 29480272 |
Cataract | 19.32 | 15.09 | 18 | 77336 | 22360 | 29474813 |
Fistula | 19.30 | 15.09 | 42 | 77312 | 5097 | 29492076 |
Ischiorectal hernia | 19.28 | 15.09 | 5 | 77349 | 10 | 29497163 |
Rectosigmoid cancer | 19.20 | 15.09 | 9 | 77345 | 148 | 29497025 |
Peritoneal haematoma | 19.09 | 15.09 | 7 | 77347 | 59 | 29497114 |
Choking sensation | 18.97 | 15.09 | 18 | 77336 | 1006 | 29496167 |
Oropharyngeal spasm | 18.93 | 15.09 | 9 | 77345 | 153 | 29497020 |
Metastases to spleen | 18.89 | 15.09 | 12 | 77342 | 368 | 29496805 |
Perineal disorder | 18.89 | 15.09 | 7 | 77347 | 61 | 29497112 |
Neck pain | 18.81 | 15.09 | 17 | 77337 | 21430 | 29475743 |
Gastrointestinal stoma complication | 18.73 | 15.09 | 19 | 77335 | 1153 | 29496020 |
Malaise | 18.68 | 15.09 | 548 | 76806 | 159054 | 29338119 |
Metastases to bone marrow | 18.59 | 15.09 | 13 | 77341 | 469 | 29496704 |
Sleep disorder | 18.38 | 15.09 | 22 | 77332 | 24364 | 29472809 |
Appendicitis noninfective | 18.37 | 15.09 | 5 | 77349 | 13 | 29497160 |
Fixed eruption | 18.33 | 15.09 | 19 | 77335 | 1183 | 29495990 |
Haemoglobin abnormal | 18.24 | 15.09 | 31 | 77323 | 3130 | 29494043 |
Conjunctivitis | 18.14 | 15.09 | 54 | 77300 | 7944 | 29489229 |
Nephritis allergic | 18.08 | 15.09 | 12 | 77342 | 397 | 29496776 |
Chemical peritonitis | 18.03 | 15.09 | 8 | 77346 | 115 | 29497058 |
B-cell small lymphocytic lymphoma | 17.91 | 15.09 | 8 | 77346 | 117 | 29497056 |
Microangiopathic haemolytic anaemia | 17.72 | 15.09 | 16 | 77338 | 839 | 29496334 |
Balance disorder | 17.72 | 15.09 | 43 | 77311 | 36127 | 29461046 |
Amaurosis fugax | 17.55 | 15.09 | 13 | 77341 | 514 | 29496659 |
Wheezing | 17.51 | 15.09 | 38 | 77316 | 33202 | 29463971 |
Proteus infection | 17.40 | 15.09 | 16 | 77338 | 859 | 29496314 |
Vascular injury | 17.39 | 15.09 | 10 | 77344 | 255 | 29496918 |
Perineal ulceration | 17.38 | 15.09 | 5 | 77349 | 17 | 29497156 |
Oedema peripheral | 17.36 | 15.09 | 180 | 77174 | 103377 | 29393796 |
Acute motor-sensory axonal neuropathy | 17.32 | 15.09 | 8 | 77346 | 127 | 29497046 |
Oral dysaesthesia | 17.29 | 15.09 | 7 | 77347 | 79 | 29497094 |
Peritoneal disorder | 17.28 | 15.09 | 10 | 77344 | 258 | 29496915 |
Haematemesis | 17.27 | 15.09 | 117 | 77237 | 24509 | 29472664 |
Blood triglycerides increased | 17.24 | 15.09 | 6 | 77348 | 12828 | 29484345 |
Pulmonary hypertension | 17.23 | 15.09 | 14 | 77340 | 18594 | 29478579 |
Duodenal stenosis | 17.22 | 15.09 | 9 | 77345 | 189 | 29496984 |
Angioedema | 17.21 | 15.09 | 36 | 77318 | 31879 | 29465294 |
Tunnel vision | 17.16 | 15.09 | 12 | 77342 | 433 | 29496740 |
Metastases to pelvis | 17.04 | 15.09 | 10 | 77344 | 265 | 29496908 |
Intrahepatic portal hepatic venous fistula | 17.03 | 15.09 | 4 | 77350 | 4 | 29497169 |
Blindness transient | 17.02 | 15.09 | 23 | 77331 | 1897 | 29495276 |
Abdominal sepsis | 16.99 | 15.09 | 16 | 77338 | 886 | 29496287 |
Obstructive airways disorder | 16.92 | 15.09 | 4 | 77350 | 11012 | 29486161 |
Lower respiratory tract infection | 16.87 | 15.09 | 27 | 77327 | 26475 | 29470698 |
VIth nerve disorder | 16.75 | 15.09 | 5 | 77349 | 20 | 29497153 |
Diffuse large B-cell lymphoma refractory | 16.69 | 15.09 | 16 | 77338 | 906 | 29496267 |
Thrombotic thrombocytopenic purpura | 16.63 | 15.09 | 30 | 77324 | 3176 | 29493997 |
Phrenic nerve paralysis | 16.48 | 15.09 | 7 | 77347 | 90 | 29497083 |
Bacterial colitis | 16.42 | 15.09 | 6 | 77348 | 50 | 29497123 |
Nail disorder | 16.40 | 15.09 | 22 | 77332 | 1802 | 29495371 |
Peripheral motor neuropathy | 16.39 | 15.09 | 21 | 77333 | 1644 | 29495529 |
Hypersomnia | 16.33 | 15.09 | 4 | 77350 | 10750 | 29486423 |
Hypotension | 16.32 | 15.09 | 642 | 76712 | 193712 | 29303461 |
Infusion site urticaria | 16.27 | 15.09 | 7 | 77347 | 93 | 29497080 |
Prostate cancer | 16.26 | 15.09 | 26 | 77328 | 25501 | 29471672 |
Pancreatitis | 16.15 | 15.09 | 42 | 77312 | 34472 | 29462701 |
Xerosis | 16.12 | 15.09 | 12 | 77342 | 478 | 29496695 |
Abdominal mass | 16.09 | 15.09 | 18 | 77336 | 1222 | 29495951 |
Blood pressure increased | 16.02 | 15.09 | 120 | 77234 | 73683 | 29423490 |
Ichthyosis | 16.01 | 15.09 | 7 | 77347 | 97 | 29497076 |
Prostatic calcification | 16.01 | 15.09 | 7 | 77347 | 97 | 29497076 |
Colon cancer recurrent | 15.94 | 15.09 | 7 | 77347 | 98 | 29497075 |
Electromyogram abnormal | 15.92 | 15.09 | 6 | 77348 | 55 | 29497118 |
Retroperitoneal abscess | 15.88 | 15.09 | 8 | 77346 | 155 | 29497018 |
Radiation interaction | 15.85 | 15.09 | 5 | 77349 | 25 | 29497148 |
Stevens-Johnson syndrome | 15.80 | 15.09 | 12 | 77342 | 16485 | 29480688 |
Rectal obstruction | 15.77 | 15.09 | 4 | 77350 | 7 | 29497166 |
Pneumoperitoneum | 15.74 | 15.09 | 20 | 77334 | 1553 | 29495620 |
Trichomegaly | 15.69 | 15.09 | 5 | 77349 | 26 | 29497147 |
Gastrointestinal mucosal necrosis | 15.65 | 15.09 | 8 | 77346 | 160 | 29497013 |
Blood glucose decreased | 15.61 | 15.09 | 6 | 77348 | 12063 | 29485110 |
Product administration error | 15.61 | 15.09 | 9 | 77345 | 14301 | 29482872 |
Bradycardia | 15.57 | 15.09 | 104 | 77250 | 65525 | 29431648 |
Neurosarcoidosis | 15.56 | 15.09 | 8 | 77346 | 162 | 29497011 |
Therapeutic product effect prolonged | 15.56 | 15.09 | 9 | 77345 | 232 | 29496941 |
Respiratory depression | 15.48 | 15.09 | 8 | 77346 | 13515 | 29483658 |
Vestibular neuronitis | 15.39 | 15.09 | 8 | 77346 | 166 | 29497007 |
Proctitis | 15.28 | 15.09 | 23 | 77331 | 2096 | 29495077 |
Limb injury | 15.18 | 15.09 | 3 | 77351 | 9352 | 29487821 |
Skin laceration | 15.16 | 15.09 | 5 | 77349 | 11057 | 29486116 |
Soft tissue swelling | 15.14 | 15.09 | 10 | 77344 | 328 | 29496845 |
Faeces discoloured | 15.14 | 15.09 | 8 | 77346 | 13343 | 29483830 |
Hypophagia | 15.13 | 15.09 | 100 | 77254 | 20772 | 29476401 |
Type III immune complex mediated reaction | 15.12 | 15.09 | 9 | 77345 | 245 | 29496928 |
Hyperlipidaemia | 15.10 | 15.09 | 7 | 77347 | 12583 | 29484590 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neuropathy peripheral | 2383.96 | 15.31 | 1865 | 116609 | 115660 | 64264598 |
Neutropenia | 1406.86 | 15.31 | 1953 | 116521 | 237671 | 64142587 |
Neurotoxicity | 1250.47 | 15.31 | 721 | 117753 | 26683 | 64353575 |
Disease progression | 1214.65 | 15.31 | 1396 | 117078 | 140284 | 64239974 |
Thrombocytopenia | 1049.48 | 15.31 | 1642 | 116832 | 222159 | 64158099 |
Diarrhoea | 976.97 | 15.31 | 3221 | 115253 | 719483 | 63660775 |
Palmar-plantar erythrodysaesthesia syndrome | 881.84 | 15.31 | 588 | 117886 | 28231 | 64352027 |
Laryngospasm | 848.92 | 15.31 | 296 | 118178 | 3149 | 64377109 |
Dermatitis acneiform | 794.41 | 15.31 | 362 | 118112 | 8081 | 64372177 |
Paraesthesia | 662.99 | 15.31 | 1011 | 117463 | 133511 | 64246747 |
Skin toxicity | 655.78 | 15.31 | 294 | 118180 | 6308 | 64373950 |
Arteriospasm coronary | 625.87 | 15.31 | 269 | 118205 | 5196 | 64375062 |
Mucosal inflammation | 573.23 | 15.31 | 639 | 117835 | 61945 | 64318313 |
Peripheral sensory neuropathy | 520.45 | 15.31 | 300 | 118174 | 11078 | 64369180 |
Bone marrow failure | 508.26 | 15.31 | 529 | 117945 | 47423 | 64332835 |
Vomiting | 500.32 | 15.31 | 2167 | 116307 | 548950 | 63831308 |
Myelosuppression | 466.13 | 15.31 | 371 | 118103 | 23459 | 64356799 |
Venoocclusive liver disease | 457.90 | 15.31 | 264 | 118210 | 9751 | 64370507 |
Arthralgia | 453.54 | 15.31 | 126 | 118348 | 442134 | 63938124 |
Erythema | 423.37 | 15.31 | 1009 | 117465 | 186061 | 64194197 |
Polyneuropathy | 422.14 | 15.31 | 325 | 118149 | 19569 | 64360689 |
Metastases to liver | 414.16 | 15.31 | 347 | 118127 | 23594 | 64356664 |
Bronchospasm | 407.99 | 15.31 | 330 | 118144 | 21352 | 64358906 |
Drug ineffective | 394.79 | 15.31 | 585 | 117889 | 839662 | 63540596 |
Paronychia | 387.34 | 15.31 | 204 | 118270 | 6288 | 64373970 |
Interstitial lung disease | 357.81 | 15.31 | 643 | 117831 | 97089 | 64283169 |
Headache | 357.35 | 15.31 | 271 | 118203 | 529196 | 63851062 |
Portal hypertension | 352.91 | 15.31 | 189 | 118285 | 6030 | 64374228 |
Nausea | 346.95 | 15.31 | 2545 | 115929 | 783255 | 63597003 |
Chills | 339.57 | 15.31 | 767 | 117707 | 136497 | 64243761 |
Gastrointestinal perforation | 325.19 | 15.31 | 171 | 118303 | 5253 | 64375005 |
Enteritis | 311.69 | 15.31 | 222 | 118252 | 11855 | 64368403 |
Gastrointestinal toxicity | 308.35 | 15.31 | 164 | 118310 | 5158 | 64375100 |
Haematotoxicity | 303.11 | 15.31 | 224 | 118250 | 12672 | 64367586 |
Product dose omission issue | 298.85 | 15.31 | 14 | 118460 | 194733 | 64185525 |
Dysaesthesia pharynx | 290.61 | 15.31 | 69 | 118405 | 137 | 64380121 |
Joint swelling | 286.24 | 15.31 | 31 | 118443 | 215351 | 64164907 |
Fall | 280.14 | 15.31 | 214 | 118260 | 416612 | 63963646 |
Throat tightness | 260.67 | 15.31 | 264 | 118210 | 22896 | 64357362 |
Neutrophil count decreased | 248.81 | 15.31 | 481 | 117993 | 76715 | 64303543 |
Stridor | 248.49 | 15.31 | 138 | 118336 | 4736 | 64375522 |
Neoplasm progression | 243.81 | 15.31 | 337 | 118137 | 40627 | 64339631 |
Metastases to lung | 235.00 | 15.31 | 207 | 118267 | 15057 | 64365201 |
Cardiotoxicity | 231.50 | 15.31 | 174 | 118300 | 10100 | 64370158 |
Stomatitis | 226.15 | 15.31 | 571 | 117903 | 109034 | 64271224 |
Type I hypersensitivity | 223.75 | 15.31 | 116 | 118358 | 3458 | 64376800 |
Pain | 223.38 | 15.31 | 424 | 118050 | 553087 | 63827171 |
Drug abuse | 222.96 | 15.31 | 4 | 118470 | 132370 | 64247888 |
Leukopenia | 217.88 | 15.31 | 536 | 117938 | 100706 | 64279552 |
Malignant neoplasm progression | 213.34 | 15.31 | 569 | 117905 | 112302 | 64267956 |
Focal nodular hyperplasia | 207.37 | 15.31 | 68 | 118406 | 589 | 64379669 |
Dysarthria | 204.82 | 15.31 | 381 | 118093 | 59025 | 64321233 |
Arthropathy | 202.33 | 15.31 | 4 | 118470 | 120963 | 64259295 |
Weight increased | 201.75 | 15.31 | 70 | 118404 | 213278 | 64166980 |
Hyperammonaemia | 199.65 | 15.31 | 157 | 118317 | 9747 | 64370511 |
Peripheral swelling | 198.86 | 15.31 | 68 | 118406 | 209085 | 64171173 |
Decreased appetite | 197.00 | 15.31 | 1028 | 117446 | 280261 | 64099997 |
Hyperammonaemic encephalopathy | 196.29 | 15.31 | 111 | 118363 | 3947 | 64376311 |
Flushing | 194.88 | 15.31 | 440 | 118034 | 78208 | 64302050 |
Non-cirrhotic portal hypertension | 192.48 | 15.31 | 57 | 118417 | 338 | 64379920 |
Drug interaction | 188.49 | 15.31 | 233 | 118241 | 361850 | 64018408 |
Depression | 182.36 | 15.31 | 55 | 118419 | 183236 | 64197022 |
Sinusitis | 181.64 | 15.31 | 26 | 118448 | 145902 | 64234356 |
Abdominal pain | 181.13 | 15.31 | 1085 | 117389 | 311290 | 64068968 |
Ascites | 178.96 | 15.31 | 369 | 118105 | 61632 | 64318626 |
Febrile neutropenia | 178.45 | 15.31 | 750 | 117724 | 186907 | 64193351 |
Nasopharyngitis | 172.60 | 15.31 | 72 | 118402 | 196001 | 64184257 |
Anaphylactic shock | 172.26 | 15.31 | 244 | 118230 | 30084 | 64350174 |
Insomnia | 170.40 | 15.31 | 75 | 118399 | 197761 | 64182497 |
Splenomegaly | 168.78 | 15.31 | 186 | 118288 | 17775 | 64362483 |
Therapy partial responder | 167.88 | 15.31 | 144 | 118330 | 10104 | 64370154 |
Swelling | 165.05 | 15.31 | 45 | 118429 | 160173 | 64220085 |
Dysphonia | 161.78 | 15.31 | 299 | 118175 | 46083 | 64334175 |
Overdose | 158.51 | 15.31 | 48 | 118426 | 159518 | 64220740 |
Contraindicated product administered | 158.35 | 15.31 | 10 | 118464 | 107819 | 64272439 |
Proteinuria | 157.39 | 15.31 | 223 | 118251 | 27500 | 64352758 |
Nodular regenerative hyperplasia | 155.53 | 15.31 | 59 | 118415 | 811 | 64379447 |
Intestinal obstruction | 155.30 | 15.31 | 256 | 118218 | 36030 | 64344228 |
Feeling hot | 152.57 | 15.31 | 289 | 118185 | 45374 | 64334884 |
Hypersensitivity | 152.20 | 15.31 | 739 | 117735 | 195713 | 64184545 |
Product use issue | 151.86 | 15.31 | 45 | 118429 | 151670 | 64228588 |
Hypomagnesaemia | 149.72 | 15.31 | 256 | 118218 | 37120 | 64343138 |
Pyrexia | 145.07 | 15.31 | 1615 | 116859 | 557029 | 63823229 |
Contusion | 142.52 | 15.31 | 20 | 118454 | 113945 | 64266313 |
Therapeutic product effect decreased | 142.49 | 15.31 | 21 | 118453 | 115330 | 64264928 |
Pain in extremity | 138.62 | 15.31 | 214 | 118260 | 302871 | 64077387 |
Maternal exposure during pregnancy | 137.55 | 15.31 | 10 | 118464 | 95874 | 64284384 |
Influenza | 137.28 | 15.31 | 17 | 118457 | 106514 | 64273744 |
Injection site pain | 135.97 | 15.31 | 21 | 118453 | 111387 | 64268871 |
Paraesthesia oral | 133.92 | 15.31 | 142 | 118332 | 12989 | 64367269 |
Pneumonia | 133.65 | 15.31 | 552 | 117922 | 559024 | 63821234 |
Hyperhidrosis | 133.59 | 15.31 | 518 | 117956 | 124402 | 64255856 |
Cytokine release syndrome | 132.46 | 15.31 | 177 | 118297 | 20652 | 64359606 |
Abdominal discomfort | 132.24 | 15.31 | 86 | 118388 | 182236 | 64198022 |
Cardiac failure congestive | 132.01 | 15.31 | 38 | 118436 | 130542 | 64249716 |
Dyspnoea | 129.78 | 15.31 | 1943 | 116531 | 716731 | 63663527 |
Carcinoembryonic antigen increased | 129.48 | 15.31 | 65 | 118409 | 1808 | 64378450 |
Dysaesthesia | 129.29 | 15.31 | 92 | 118382 | 4903 | 64375355 |
Asthma | 128.23 | 15.31 | 13 | 118461 | 95212 | 64285046 |
Systemic lupus erythematosus | 128.06 | 15.31 | 3 | 118471 | 77609 | 64302649 |
Varices oesophageal | 124.81 | 15.31 | 91 | 118383 | 5039 | 64375219 |
Oxygen saturation decreased | 124.18 | 15.31 | 456 | 118018 | 106720 | 64273538 |
Large intestine perforation | 122.73 | 15.31 | 133 | 118341 | 12471 | 64367787 |
Tumour perforation | 122.53 | 15.31 | 39 | 118435 | 304 | 64379954 |
Anastomotic leak | 122.06 | 15.31 | 51 | 118423 | 915 | 64379343 |
Somnolence | 121.36 | 15.31 | 117 | 118357 | 203528 | 64176730 |
Dehydration | 120.44 | 15.31 | 745 | 117729 | 216018 | 64164240 |
Anxiety | 120.10 | 15.31 | 117 | 118357 | 202532 | 64177726 |
Bronchitis | 118.84 | 15.31 | 27 | 118447 | 108716 | 64271542 |
Intentional product misuse | 118.50 | 15.31 | 3 | 118471 | 72292 | 64307966 |
Enterocolitis | 117.34 | 15.31 | 127 | 118347 | 11891 | 64368367 |
Suicide attempt | 116.18 | 15.31 | 3 | 118471 | 71004 | 64309254 |
Laryngeal discomfort | 115.75 | 15.31 | 41 | 118433 | 458 | 64379800 |
Arthritis | 114.01 | 15.31 | 11 | 118463 | 83803 | 64296455 |
Immune thrombocytopenia | 113.07 | 15.31 | 139 | 118335 | 14927 | 64365331 |
Skin reaction | 112.75 | 15.31 | 126 | 118348 | 12226 | 64368032 |
Colorectal cancer metastatic | 112.36 | 15.31 | 48 | 118426 | 912 | 64379346 |
Asthenia | 112.06 | 15.31 | 1240 | 117234 | 426804 | 63953454 |
Intravascular haemolysis | 111.54 | 15.31 | 44 | 118430 | 676 | 64379582 |
Metastases to peritoneum | 107.52 | 15.31 | 72 | 118402 | 3475 | 64376783 |
Hospitalisation | 107.42 | 15.31 | 8 | 118466 | 75199 | 64305059 |
Myalgia | 106.85 | 15.31 | 81 | 118393 | 158536 | 64221722 |
Laryngeal oedema | 106.57 | 15.31 | 95 | 118379 | 7018 | 64373240 |
Posterior reversible encephalopathy syndrome | 105.14 | 15.31 | 167 | 118307 | 22779 | 64357479 |
Hypertransaminasaemia | 103.70 | 15.31 | 94 | 118380 | 7097 | 64373161 |
Ileus | 103.66 | 15.31 | 166 | 118308 | 22800 | 64357458 |
Osteoarthritis | 102.42 | 15.31 | 3 | 118471 | 63333 | 64316925 |
Peritonitis | 101.01 | 15.31 | 172 | 118302 | 24851 | 64355407 |
Musculoskeletal stiffness | 99.45 | 15.31 | 51 | 118423 | 123155 | 64257103 |
Administration site extravasation | 98.31 | 15.31 | 45 | 118429 | 1014 | 64379244 |
Extravasation | 97.47 | 15.31 | 65 | 118409 | 3115 | 64377143 |
Condition aggravated | 96.02 | 15.31 | 356 | 118118 | 372070 | 64008188 |
Disseminated intravascular coagulation | 95.05 | 15.31 | 194 | 118280 | 32154 | 64348104 |
Injection site erythema | 94.46 | 15.31 | 10 | 118464 | 70790 | 64309468 |
Pemphigus | 94.24 | 15.31 | 4 | 118470 | 60697 | 64319561 |
Hyperthermia | 94.10 | 15.31 | 129 | 118345 | 15421 | 64364837 |
Stress | 93.94 | 15.31 | 4 | 118470 | 60530 | 64319728 |
Drug intolerance | 93.50 | 15.31 | 125 | 118349 | 187867 | 64192391 |
Lower respiratory tract infection | 92.95 | 15.31 | 29 | 118445 | 94585 | 64285673 |
Intestinal perforation | 92.61 | 15.31 | 127 | 118347 | 15186 | 64365072 |
Portal shunt | 89.75 | 15.31 | 22 | 118452 | 53 | 64380205 |
Haemolytic anaemia | 89.44 | 15.31 | 128 | 118346 | 15925 | 64364333 |
General physical health deterioration | 87.51 | 15.31 | 659 | 117815 | 203766 | 64176492 |
Exposure during pregnancy | 87.48 | 15.31 | 18 | 118456 | 77657 | 64302601 |
Suicidal ideation | 87.25 | 15.31 | 10 | 118464 | 66532 | 64313726 |
Confusional state | 86.92 | 15.31 | 222 | 118252 | 260922 | 64119336 |
Pneumatosis intestinalis | 86.72 | 15.31 | 74 | 118400 | 5155 | 64375103 |
Glossodynia | 86.66 | 15.31 | 9 | 118465 | 64687 | 64315571 |
Wound | 85.56 | 15.31 | 18 | 118456 | 76459 | 64303799 |
Hypertensive crisis | 85.25 | 15.31 | 134 | 118340 | 18114 | 64362144 |
Cholinergic syndrome | 85.17 | 15.31 | 38 | 118436 | 805 | 64379453 |
Rhabdomyolysis | 85.09 | 15.31 | 31 | 118443 | 91695 | 64288563 |
Tumour necrosis | 83.34 | 15.31 | 47 | 118427 | 1662 | 64378596 |
Dihydropyrimidine dehydrogenase deficiency | 82.30 | 15.31 | 23 | 118451 | 107 | 64380151 |
Diffuse large B-cell lymphoma recurrent | 81.55 | 15.31 | 58 | 118416 | 3088 | 64377170 |
Memory impairment | 81.11 | 15.31 | 28 | 118446 | 85654 | 64294604 |
Tongue oedema | 79.97 | 15.31 | 75 | 118399 | 5915 | 64374343 |
Anastomotic complication | 78.26 | 15.31 | 29 | 118445 | 372 | 64379886 |
Fluid retention | 78.04 | 15.31 | 9 | 118465 | 59597 | 64320661 |
Drug hypersensitivity | 77.73 | 15.31 | 204 | 118270 | 237611 | 64142647 |
Incorrect dose administered | 77.54 | 15.31 | 10 | 118464 | 60755 | 64319503 |
Electrocardiogram QT prolonged | 76.89 | 15.31 | 25 | 118449 | 79423 | 64300835 |
Infusion related reaction | 76.56 | 15.31 | 541 | 117933 | 163926 | 64216332 |
Inappropriate schedule of product administration | 76.27 | 15.31 | 37 | 118437 | 92249 | 64288009 |
Acute coronary syndrome | 75.66 | 15.31 | 131 | 118343 | 19179 | 64361079 |
Blood cholesterol increased | 75.46 | 15.31 | 4 | 118470 | 50062 | 64330196 |
Off label use | 74.13 | 15.31 | 1599 | 116875 | 631207 | 63749051 |
Anastomotic fistula | 73.60 | 15.31 | 20 | 118454 | 82 | 64380176 |
Toxic leukoencephalopathy | 72.95 | 15.31 | 35 | 118439 | 880 | 64379378 |
Aggression | 71.92 | 15.31 | 3 | 118471 | 46229 | 64334029 |
Pulmonary embolism | 71.40 | 15.31 | 487 | 117987 | 145869 | 64234389 |
Chronic obstructive pulmonary disease | 71.19 | 15.31 | 21 | 118453 | 71027 | 64309231 |
Nicotinic acid deficiency | 71.13 | 15.31 | 21 | 118453 | 123 | 64380135 |
Hepatic enzyme increased | 70.25 | 15.31 | 81 | 118393 | 129862 | 64250396 |
Stomal varices | 70.24 | 15.31 | 17 | 118457 | 38 | 64380220 |
Rectal perforation | 69.63 | 15.31 | 32 | 118442 | 728 | 64379530 |
Electrocardiogram ST segment elevation | 69.62 | 15.31 | 76 | 118398 | 7183 | 64373075 |
Stress cardiomyopathy | 68.81 | 15.31 | 85 | 118389 | 9172 | 64371086 |
Leukoencephalopathy | 68.67 | 15.31 | 74 | 118400 | 6893 | 64373365 |
Tumour lysis syndrome | 68.62 | 15.31 | 126 | 118348 | 19314 | 64360944 |
Mobility decreased | 68.57 | 15.31 | 36 | 118438 | 85804 | 64294454 |
Myocardial infarction | 68.39 | 15.31 | 125 | 118349 | 165696 | 64214562 |
Hypokalaemia | 67.62 | 15.31 | 419 | 118055 | 121484 | 64258774 |
Vascular pain | 67.08 | 15.31 | 32 | 118442 | 794 | 64379464 |
Hypertension | 66.73 | 15.31 | 749 | 117725 | 258512 | 64121746 |
Injection site reaction | 66.53 | 15.31 | 5 | 118469 | 46659 | 64333599 |
Anaphylactic reaction | 66.36 | 15.31 | 276 | 118198 | 68388 | 64311870 |
Neuromyotonia | 66.01 | 15.31 | 18 | 118456 | 75 | 64380183 |
Platelet count decreased | 65.30 | 15.31 | 529 | 117945 | 167182 | 64213076 |
Upper respiratory tract infection | 65.17 | 15.31 | 26 | 118448 | 72759 | 64307499 |
Osteoporosis | 64.57 | 15.31 | 3 | 118471 | 42077 | 64338181 |
Cholangitis | 64.44 | 15.31 | 89 | 118385 | 10713 | 64369545 |
Coronary artery disease | 64.05 | 15.31 | 16 | 118458 | 60417 | 64319841 |
Hiccups | 64.02 | 15.31 | 78 | 118396 | 8298 | 64371960 |
Evans syndrome | 63.38 | 15.31 | 25 | 118449 | 384 | 64379874 |
Feeling abnormal | 63.24 | 15.31 | 92 | 118382 | 133510 | 64246748 |
Hypoalbuminaemia | 62.94 | 15.31 | 115 | 118359 | 17559 | 64362699 |
Blood pressure fluctuation | 62.77 | 15.31 | 10 | 118464 | 51861 | 64328397 |
Subileus | 62.04 | 15.31 | 60 | 118414 | 4917 | 64375341 |
Migraine | 61.94 | 15.31 | 19 | 118455 | 62658 | 64317600 |
Blood glucose increased | 61.15 | 15.31 | 54 | 118420 | 98019 | 64282239 |
Band sensation | 60.76 | 15.31 | 28 | 118446 | 641 | 64379617 |
Colon cancer metastatic | 60.62 | 15.31 | 40 | 118434 | 1883 | 64378375 |
Hallucination | 60.43 | 15.31 | 29 | 118445 | 72759 | 64307499 |
Drug reaction with eosinophilia and systemic symptoms | 60.15 | 15.31 | 13 | 118461 | 54204 | 64326054 |
Metastases to lymph nodes | 59.96 | 15.31 | 77 | 118397 | 8640 | 64371618 |
Rash pustular | 59.80 | 15.31 | 82 | 118392 | 9803 | 64370455 |
Gastrointestinal anastomotic leak | 59.72 | 15.31 | 24 | 118450 | 388 | 64379870 |
Dizziness | 59.42 | 15.31 | 505 | 117969 | 429658 | 63950600 |
Gait disturbance | 59.07 | 15.31 | 144 | 118330 | 172011 | 64208247 |
Periportal sinus dilatation | 58.57 | 15.31 | 14 | 118460 | 29 | 64380229 |
Herpes zoster | 57.85 | 15.31 | 37 | 118437 | 79150 | 64301108 |
Sedation | 57.56 | 15.31 | 5 | 118469 | 41457 | 64338801 |
Chemical peritonitis | 57.12 | 15.31 | 21 | 118453 | 263 | 64379995 |
Injection site pruritus | 57.07 | 15.31 | 3 | 118471 | 37823 | 64342435 |
Stoma site haemorrhage | 56.87 | 15.31 | 36 | 118438 | 1577 | 64378681 |
Choking sensation | 56.53 | 15.31 | 49 | 118425 | 3486 | 64376772 |
Speech disorder | 55.97 | 15.31 | 206 | 118268 | 48235 | 64332023 |
Mucosal toxicity | 55.61 | 15.31 | 24 | 118450 | 468 | 64379790 |
Cellulitis | 55.52 | 15.31 | 54 | 118420 | 93603 | 64286655 |
Oesophageal varices haemorrhage | 55.42 | 15.31 | 49 | 118425 | 3580 | 64376678 |
Influenza like illness | 55.31 | 15.31 | 22 | 118452 | 61680 | 64318578 |
International normalised ratio increased | 55.14 | 15.31 | 39 | 118435 | 79128 | 64301130 |
Hyperbilirubinaemia | 55.13 | 15.31 | 121 | 118353 | 21084 | 64359174 |
Large intestinal obstruction | 54.81 | 15.31 | 43 | 118431 | 2659 | 64377599 |
Emotional distress | 53.93 | 15.31 | 3 | 118471 | 36035 | 64344223 |
Cyanosis | 53.77 | 15.31 | 123 | 118351 | 22032 | 64358226 |
Treatment failure | 53.77 | 15.31 | 82 | 118392 | 116734 | 64263524 |
Anaemia | 53.62 | 15.31 | 985 | 117489 | 377695 | 64002563 |
Treatment noncompliance | 53.48 | 15.31 | 8 | 118466 | 43474 | 64336784 |
Palmar erythema | 52.52 | 15.31 | 35 | 118439 | 1675 | 64378583 |
Ocular toxicity | 52.38 | 15.31 | 25 | 118449 | 621 | 64379637 |
Hepatic atrophy | 52.38 | 15.31 | 22 | 118452 | 400 | 64379858 |
Diffuse large B-cell lymphoma refractory | 52.36 | 15.31 | 30 | 118444 | 1094 | 64379164 |
ECG signs of myocardial ischaemia | 52.34 | 15.31 | 21 | 118453 | 338 | 64379920 |
Encapsulating peritoneal sclerosis | 52.28 | 15.31 | 27 | 118447 | 798 | 64379460 |
Wrong technique in product usage process | 52.26 | 15.31 | 27 | 118447 | 64947 | 64315311 |
Metastasis | 51.81 | 15.31 | 58 | 118416 | 5637 | 64374621 |
Prinzmetal angina | 51.64 | 15.31 | 33 | 118441 | 1470 | 64378788 |
Necrotising fasciitis | 51.50 | 15.31 | 56 | 118418 | 5270 | 64374988 |
Drug level increased | 50.70 | 15.31 | 3 | 118471 | 34193 | 64346065 |
Hepatic failure | 50.68 | 15.31 | 219 | 118255 | 55175 | 64325083 |
Enterocutaneous fistula | 50.57 | 15.31 | 33 | 118441 | 1524 | 64378734 |
Helicobacter infection | 49.70 | 15.31 | 6 | 118468 | 38356 | 64341902 |
Cough | 49.58 | 15.31 | 338 | 118136 | 301810 | 64078448 |
Hypervolaemia | 49.57 | 15.31 | 6 | 118468 | 38279 | 64341979 |
Urinary tract infection | 49.33 | 15.31 | 238 | 118236 | 231358 | 64148900 |
Nasal congestion | 49.17 | 15.31 | 24 | 118450 | 59634 | 64320624 |
Drug dependence | 49.16 | 15.31 | 3 | 118471 | 33309 | 64346949 |
Enterovesical fistula | 48.78 | 15.31 | 27 | 118447 | 920 | 64379338 |
Gastric perforation | 48.75 | 15.31 | 45 | 118429 | 3478 | 64376780 |
Psychotic disorder | 48.47 | 15.31 | 4 | 118470 | 34574 | 64345684 |
Dysphagia | 48.30 | 15.31 | 349 | 118125 | 106463 | 64273795 |
Blister | 47.63 | 15.31 | 47 | 118427 | 80920 | 64299338 |
Ileal perforation | 47.41 | 15.31 | 26 | 118448 | 870 | 64379388 |
Pericarditis | 47.35 | 15.31 | 28 | 118446 | 62488 | 64317770 |
Pulmonary toxicity | 47.31 | 15.31 | 68 | 118406 | 8493 | 64371765 |
Acute abdomen | 46.90 | 15.31 | 40 | 118434 | 2784 | 64377474 |
Transdifferentiation of neoplasm | 46.31 | 15.31 | 14 | 118460 | 90 | 64380168 |
Septic shock | 46.24 | 15.31 | 342 | 118132 | 105095 | 64275163 |
Diabetes mellitus | 45.96 | 15.31 | 33 | 118441 | 66441 | 64313817 |
Liver function test abnormal | 45.85 | 15.31 | 26 | 118448 | 59375 | 64320883 |
Metastases to bone marrow | 45.64 | 15.31 | 23 | 118451 | 645 | 64379613 |
Metastases to spleen | 45.40 | 15.31 | 21 | 118453 | 485 | 64379773 |
Sleep disorder | 44.86 | 15.31 | 27 | 118447 | 59682 | 64320576 |
Productive cough | 44.80 | 15.31 | 41 | 118433 | 73162 | 64307096 |
Formication | 44.21 | 15.31 | 47 | 118427 | 4310 | 64375948 |
Steatohepatitis | 44.20 | 15.31 | 24 | 118450 | 787 | 64379471 |
Malignant ascites | 43.84 | 15.31 | 26 | 118448 | 1012 | 64379246 |
Viral infection | 43.65 | 15.31 | 7 | 118467 | 36133 | 64344125 |
Hypoglycaemia | 43.42 | 15.31 | 61 | 118413 | 89831 | 64290427 |
Biliary tract infection | 43.28 | 15.31 | 25 | 118449 | 926 | 64379332 |
Head injury | 42.89 | 15.31 | 5 | 118469 | 32837 | 64347421 |
Performance status decreased | 42.71 | 15.31 | 51 | 118423 | 5313 | 64374945 |
Oxygen saturation normal | 42.41 | 15.31 | 8 | 118466 | 0 | 64380258 |
White blood cell count decreased | 41.93 | 15.31 | 459 | 118015 | 157378 | 64222880 |
Cataract | 41.67 | 15.31 | 21 | 118453 | 51241 | 64329017 |
Hyperpyrexia | 41.63 | 15.31 | 49 | 118425 | 5028 | 64375230 |
Colitis | 41.30 | 15.31 | 215 | 118259 | 58459 | 64321799 |
Haemoglobinuria | 40.81 | 15.31 | 22 | 118452 | 711 | 64379547 |
Splenorenal shunt | 40.55 | 15.31 | 9 | 118465 | 11 | 64380247 |
Skin fissures | 40.48 | 15.31 | 70 | 118404 | 10236 | 64370022 |
Hyperkalaemia | 40.12 | 15.31 | 78 | 118396 | 101051 | 64279207 |
Nervousness | 39.87 | 15.31 | 4 | 118470 | 29552 | 64350706 |
Cold sweat | 39.54 | 15.31 | 91 | 118383 | 16364 | 64363894 |
Unevaluable event | 39.11 | 15.31 | 22 | 118452 | 50467 | 64329791 |
Tachycardia | 38.82 | 15.31 | 433 | 118041 | 149146 | 64231112 |
Type II hypersensitivity | 38.49 | 15.31 | 10 | 118464 | 33 | 64380225 |
Medication error | 38.38 | 15.31 | 22 | 118452 | 49944 | 64330314 |
Trismus | 38.04 | 15.31 | 46 | 118428 | 4855 | 64375403 |
Lip oedema | 37.53 | 15.31 | 47 | 118427 | 5142 | 64375116 |
Oropharyngeal pain | 37.51 | 15.31 | 66 | 118408 | 88801 | 64291457 |
Acute respiratory distress syndrome | 37.21 | 15.31 | 156 | 118318 | 38779 | 64341479 |
Basal cell carcinoma | 37.19 | 15.31 | 6 | 118468 | 30832 | 64349426 |
Cardiac disorder | 36.93 | 15.31 | 29 | 118445 | 55787 | 64324471 |
Cold dysaesthesia | 36.88 | 15.31 | 8 | 118466 | 8 | 64380250 |
Recall phenomenon | 36.84 | 15.31 | 23 | 118451 | 983 | 64379275 |
K-ras gene mutation | 36.80 | 15.31 | 10 | 118464 | 41 | 64380217 |
Irritability | 36.55 | 15.31 | 11 | 118463 | 36735 | 64343523 |
Underdose | 36.17 | 15.31 | 3 | 118471 | 25826 | 64354432 |
Portal vein dilatation | 36.05 | 15.31 | 10 | 118464 | 45 | 64380213 |
Discomfort | 36.04 | 15.31 | 58 | 118416 | 80820 | 64299438 |
Portal venous gas | 35.99 | 15.31 | 16 | 118458 | 336 | 64379922 |
Heart rate decreased | 35.94 | 15.31 | 29 | 118445 | 55038 | 64325220 |
Factor VII deficiency | 35.80 | 15.31 | 9 | 118465 | 25 | 64380233 |
Small intestinal perforation | 35.79 | 15.31 | 33 | 118441 | 2547 | 64377711 |
Peripheral motor neuropathy | 35.52 | 15.31 | 35 | 118439 | 2935 | 64377323 |
Abnormal behaviour | 35.44 | 15.31 | 9 | 118465 | 33613 | 64346645 |
Duodenal ulcer perforation | 35.11 | 15.31 | 10 | 118464 | 34615 | 64345643 |
Infusion related hypersensitivity reaction | 35.06 | 15.31 | 13 | 118461 | 167 | 64380091 |
Hepatocellular injury | 34.82 | 15.31 | 170 | 118304 | 45065 | 64335193 |
Neck pain | 34.73 | 15.31 | 37 | 118437 | 61496 | 64318762 |
Splenic artery thrombosis | 34.71 | 15.31 | 10 | 118464 | 53 | 64380205 |
Haematoma | 34.62 | 15.31 | 21 | 118453 | 46229 | 64334029 |
Hallucination, visual | 34.51 | 15.31 | 5 | 118469 | 27829 | 64352429 |
Product prescribing error | 34.29 | 15.31 | 11 | 118463 | 35258 | 64345000 |
Guillain-Barre syndrome | 34.19 | 15.31 | 55 | 118419 | 7580 | 64372678 |
Hypertrichosis | 34.07 | 15.31 | 23 | 118451 | 1125 | 64379133 |
Perforation | 34.07 | 15.31 | 23 | 118451 | 1125 | 64379133 |
Balance disorder | 33.93 | 15.31 | 64 | 118410 | 83862 | 64296396 |
COVID-19 | 33.71 | 15.31 | 42 | 118432 | 65098 | 64315160 |
Blood pressure immeasurable | 33.69 | 15.31 | 28 | 118446 | 1880 | 64378378 |
Laryngeal dyspnoea | 33.62 | 15.31 | 14 | 118460 | 249 | 64380009 |
Pharyngeal paraesthesia | 33.58 | 15.31 | 28 | 118446 | 1889 | 64378369 |
Metastases to meninges | 33.34 | 15.31 | 33 | 118441 | 2782 | 64377476 |
Small intestinal obstruction | 33.12 | 15.31 | 107 | 118367 | 23466 | 64356792 |
Hypovolaemic shock | 33.07 | 15.31 | 64 | 118410 | 10202 | 64370056 |
Short-bowel syndrome | 33.00 | 15.31 | 16 | 118458 | 412 | 64379846 |
Road traffic accident | 32.85 | 15.31 | 8 | 118466 | 30737 | 64349521 |
Rhinorrhoea | 32.81 | 15.31 | 37 | 118437 | 59932 | 64320326 |
Aortic thrombosis | 32.69 | 15.31 | 25 | 118449 | 1489 | 64378769 |
Abortion spontaneous | 32.41 | 15.31 | 4 | 118470 | 25139 | 64355119 |
Blood pressure systolic increased | 32.33 | 15.31 | 26 | 118448 | 49427 | 64330831 |
Dysgeusia | 32.15 | 15.31 | 171 | 118303 | 46876 | 64333382 |
Embolism | 32.01 | 15.31 | 70 | 118404 | 12165 | 64368093 |
Cystitis radiation | 31.97 | 15.31 | 11 | 118463 | 112 | 64380146 |
Right ventricular ejection fraction decreased | 31.84 | 15.31 | 9 | 118465 | 44 | 64380214 |
Noninfective epididymitis | 31.81 | 15.31 | 6 | 118468 | 0 | 64380258 |
Accidental overdose | 31.69 | 15.31 | 11 | 118463 | 33546 | 64346712 |
Oesophageal haemorrhage | 31.68 | 15.31 | 25 | 118449 | 1559 | 64378699 |
Hydronephrosis | 31.64 | 15.31 | 76 | 118398 | 14049 | 64366209 |
Jaundice | 31.58 | 15.31 | 174 | 118300 | 48338 | 64331920 |
Trichomegaly | 31.52 | 15.31 | 10 | 118464 | 77 | 64380181 |
Biliary fistula | 31.52 | 15.31 | 10 | 118464 | 77 | 64380181 |
Toxicity to various agents | 31.46 | 15.31 | 474 | 118000 | 363039 | 64017219 |
Muscle contractions involuntary | 31.41 | 15.31 | 34 | 118440 | 3183 | 64377075 |
Intestinal ischaemia | 31.28 | 15.31 | 67 | 118407 | 11482 | 64368776 |
Neutropenic sepsis | 31.23 | 15.31 | 104 | 118370 | 23168 | 64357090 |
Pulmonary fibrosis | 31.16 | 15.31 | 123 | 118351 | 29755 | 64350503 |
Portal vein thrombosis | 31.10 | 15.31 | 42 | 118432 | 4949 | 64375309 |
Liver abscess | 30.74 | 15.31 | 43 | 118431 | 5237 | 64375021 |
Pulmonary artery thrombosis | 30.72 | 15.31 | 22 | 118452 | 1184 | 64379074 |
Type 2 diabetes mellitus | 30.70 | 15.31 | 12 | 118462 | 34008 | 64346250 |
Toxic epidermal necrolysis | 30.55 | 15.31 | 15 | 118459 | 37151 | 64343107 |
Oropharyngeal discomfort | 30.40 | 15.31 | 43 | 118431 | 5292 | 64374966 |
Tooth disorder | 30.30 | 15.31 | 3 | 118471 | 22399 | 64357859 |
Haematemesis | 30.21 | 15.31 | 168 | 118306 | 46831 | 64333427 |
Temperature intolerance | 29.76 | 15.31 | 54 | 118420 | 8201 | 64372057 |
Gastrooesophageal reflux disease | 29.73 | 15.31 | 68 | 118406 | 83075 | 64297183 |
Hypersplenism | 29.72 | 15.31 | 15 | 118459 | 422 | 64379836 |
Anaphylactoid reaction | 29.72 | 15.31 | 40 | 118434 | 4698 | 64375560 |
Suffocation feeling | 29.69 | 15.31 | 24 | 118450 | 1550 | 64378708 |
Full blood count abnormal | 29.43 | 15.31 | 9 | 118465 | 29748 | 64350510 |
Hypothyroidism | 29.41 | 15.31 | 19 | 118455 | 40438 | 64339820 |
Pelvic fluid collection | 29.40 | 15.31 | 17 | 118457 | 631 | 64379627 |
Femur fracture | 29.26 | 15.31 | 13 | 118461 | 34122 | 64346136 |
Neutropenic colitis | 29.23 | 15.31 | 39 | 118435 | 4542 | 64375716 |
Perforation bile duct | 29.21 | 15.31 | 8 | 118466 | 34 | 64380224 |
Hypophagia | 29.21 | 15.31 | 147 | 118327 | 39440 | 64340818 |
Appendicitis noninfective | 29.12 | 15.31 | 7 | 118467 | 15 | 64380243 |
Cytomegalovirus infection | 29.11 | 15.31 | 16 | 118458 | 37183 | 64343075 |
Oral dysaesthesia | 28.94 | 15.31 | 11 | 118463 | 152 | 64380106 |
Oedema peripheral | 28.92 | 15.31 | 247 | 118227 | 210070 | 64170188 |
Eosinophilia | 28.91 | 15.31 | 17 | 118457 | 38059 | 64342199 |
Hypotension | 28.74 | 15.31 | 909 | 117565 | 380065 | 64000193 |
Thrombocytopenic purpura | 28.73 | 15.31 | 27 | 118447 | 2135 | 64378123 |
Loss of personal independence in daily activities | 28.64 | 15.31 | 56 | 118418 | 72398 | 64307860 |
Pelvic abscess | 28.35 | 15.31 | 25 | 118449 | 1820 | 64378438 |
Failure to anastomose | 28.28 | 15.31 | 12 | 118462 | 224 | 64380034 |
Perineal disorder | 28.23 | 15.31 | 7 | 118467 | 18 | 64380240 |
Osteomyelitis | 27.91 | 15.31 | 8 | 118466 | 27579 | 64352679 |
Sciatic nerve palsy | 27.86 | 15.31 | 9 | 118465 | 74 | 64380184 |
Death | 27.74 | 15.31 | 675 | 117799 | 482030 | 63898228 |
Medical device site extravasation | 27.66 | 15.31 | 6 | 118468 | 6 | 64380252 |
Oesophagitis | 27.56 | 15.31 | 95 | 118379 | 21535 | 64358723 |
Hepatectomy | 27.53 | 15.31 | 11 | 118463 | 175 | 64380083 |
Granulocyte count decreased | 27.39 | 15.31 | 21 | 118453 | 1255 | 64379003 |
Nephrolithiasis | 27.29 | 15.31 | 24 | 118450 | 43659 | 64336599 |
Wound dehiscence | 27.25 | 15.31 | 43 | 118431 | 5831 | 64374427 |
Hypercreatinaemia | 27.21 | 15.31 | 12 | 118462 | 247 | 64380011 |
Obesity | 27.18 | 15.31 | 3 | 118471 | 20559 | 64359699 |
Oropharyngeal spasm | 27.08 | 15.31 | 12 | 118462 | 250 | 64380008 |
Tumour ulceration | 27.03 | 15.31 | 11 | 118463 | 184 | 64380074 |
Haemolytic uraemic syndrome | 26.84 | 15.31 | 35 | 118439 | 3986 | 64376272 |
Sensation of foreign body | 26.84 | 15.31 | 37 | 118437 | 4445 | 64375813 |
Impaired quality of life | 26.80 | 15.31 | 45 | 118429 | 6426 | 64373832 |
Koebner phenomenon | 26.79 | 15.31 | 8 | 118466 | 49 | 64380209 |
Blood glucose decreased | 26.78 | 15.31 | 5 | 118469 | 23118 | 64357140 |
Fistula of small intestine | 26.61 | 15.31 | 16 | 118458 | 639 | 64379619 |
Respiratory arrest | 26.55 | 15.31 | 35 | 118439 | 52950 | 64327308 |
Nephrotic syndrome | 26.48 | 15.31 | 56 | 118418 | 9511 | 64370747 |
Hyperfibrinolysis | 26.31 | 15.31 | 7 | 118467 | 26 | 64380232 |
Device issue | 26.01 | 15.31 | 5 | 118469 | 22643 | 64357615 |
Ear pain | 25.97 | 15.31 | 7 | 118467 | 25129 | 64355129 |
Full blood count decreased | 25.91 | 15.31 | 5 | 118469 | 22577 | 64357681 |
Retching | 25.89 | 15.31 | 74 | 118400 | 15182 | 64365076 |
Heart rate irregular | 25.86 | 15.31 | 9 | 118465 | 27404 | 64352854 |
Necrotising oesophagitis | 25.84 | 15.31 | 16 | 118458 | 674 | 64379584 |
Atypical haemolytic uraemic syndrome | 25.80 | 15.31 | 16 | 118458 | 676 | 64379582 |
Acute polyneuropathy | 25.56 | 15.31 | 13 | 118461 | 372 | 64379886 |
Respiratory distress | 25.40 | 15.31 | 174 | 118300 | 52157 | 64328101 |
Hyperaemia | 25.35 | 15.31 | 28 | 118446 | 2681 | 64377577 |
Hypoacusis | 25.27 | 15.31 | 8 | 118466 | 25859 | 64354399 |
Blood creatine phosphokinase increased | 25.15 | 15.31 | 43 | 118431 | 58515 | 64321743 |
Localised infection | 25.05 | 15.31 | 12 | 118462 | 30149 | 64350109 |
Drug ineffective for unapproved indication | 24.94 | 15.31 | 13 | 118461 | 31120 | 64349138 |
Skin laceration | 24.85 | 15.31 | 7 | 118467 | 24410 | 64355848 |
Tonic clonic movements | 24.83 | 15.31 | 24 | 118450 | 1965 | 64378293 |
Cholestasis | 24.71 | 15.31 | 154 | 118320 | 44718 | 64335540 |
Hepatic encephalopathy | 24.68 | 15.31 | 90 | 118384 | 20976 | 64359282 |
Subacute cutaneous lupus erythematosus | 24.48 | 15.31 | 29 | 118445 | 2996 | 64377262 |
Sinus bradycardia | 24.37 | 15.31 | 6 | 118468 | 22887 | 64357371 |
Tendonitis | 24.33 | 15.31 | 4 | 118470 | 20278 | 64359980 |
Fear | 24.15 | 15.31 | 4 | 118470 | 20167 | 64360091 |
Female genital tract fistula | 24.06 | 15.31 | 27 | 118447 | 2631 | 64377627 |
Haemorrhage intracranial | 24.03 | 15.31 | 7 | 118467 | 23877 | 64356381 |
Gastric varices haemorrhage | 23.99 | 15.31 | 12 | 118462 | 331 | 64379927 |
Retroperitoneal abscess | 23.96 | 15.31 | 12 | 118462 | 332 | 64379926 |
Adverse drug reaction | 23.85 | 15.31 | 29 | 118445 | 45435 | 64334823 |
Vasospasm | 23.64 | 15.31 | 17 | 118457 | 921 | 64379337 |
Hypoaesthesia oral | 23.50 | 15.31 | 60 | 118414 | 11520 | 64368738 |
Proctitis | 23.47 | 15.31 | 29 | 118445 | 3130 | 64377128 |
Limb injury | 23.45 | 15.31 | 7 | 118467 | 23498 | 64356760 |
Haemolysis | 23.24 | 15.31 | 58 | 118416 | 10981 | 64369277 |
Fatigue | 23.17 | 15.31 | 1132 | 117342 | 747598 | 63632660 |
Perihepatic abscess | 23.13 | 15.31 | 9 | 118465 | 133 | 64380125 |
Obstruction gastric | 23.04 | 15.31 | 20 | 118454 | 1426 | 64378832 |
Allodynia | 23.01 | 15.31 | 19 | 118455 | 1264 | 64378994 |
Catheter site extravasation | 23.01 | 15.31 | 12 | 118462 | 362 | 64379896 |
Livedo reticularis | 22.86 | 15.31 | 31 | 118443 | 3666 | 64376592 |
Carbohydrate antigen 19-9 increased | 22.86 | 15.31 | 12 | 118462 | 367 | 64379891 |
Organising pneumonia | 22.78 | 15.31 | 51 | 118423 | 9004 | 64371254 |
Chest discomfort | 22.76 | 15.31 | 319 | 118155 | 115787 | 64264471 |
Epistaxis | 22.74 | 15.31 | 278 | 118196 | 97853 | 64282405 |
Acral peeling skin syndrome | 22.65 | 15.31 | 7 | 118467 | 49 | 64380209 |
Product substitution issue | 22.64 | 15.31 | 3 | 118471 | 17858 | 64362400 |
Bradycardia | 22.60 | 15.31 | 126 | 118348 | 118093 | 64262165 |
Gastrointestinal stoma complication | 22.57 | 15.31 | 24 | 118450 | 2202 | 64378056 |
Hyperlipasaemia | 22.52 | 15.31 | 17 | 118457 | 993 | 64379265 |
Cytopenia | 22.44 | 15.31 | 71 | 118403 | 15400 | 64364858 |
Interventricular septum rupture | 22.40 | 15.31 | 6 | 118468 | 23 | 64380235 |
Surgery | 22.27 | 15.31 | 12 | 118462 | 28201 | 64352057 |
Hepatic lesion | 22.15 | 15.31 | 39 | 118435 | 5785 | 64374473 |
Multiple sclerosis | 22.14 | 15.31 | 4 | 118470 | 18937 | 64361321 |
Pulmonary hypertension | 22.12 | 15.31 | 28 | 118446 | 43111 | 64337147 |
Intervertebral disc protrusion | 22.07 | 15.31 | 5 | 118469 | 20186 | 64360072 |
Renal hydrocele | 22.00 | 15.31 | 6 | 118468 | 25 | 64380233 |
Venous thrombosis limb | 21.97 | 15.31 | 31 | 118443 | 3806 | 64376452 |
Dry eye | 21.97 | 15.31 | 13 | 118461 | 29006 | 64351252 |
Cardiomegaly | 21.96 | 15.31 | 8 | 118466 | 23676 | 64356582 |
Hepatic function abnormal | 21.90 | 15.31 | 197 | 118277 | 64116 | 64316142 |
Blood alkaline phosphatase abnormal | 21.80 | 15.31 | 15 | 118459 | 757 | 64379501 |
Platelet count increased | 21.75 | 15.31 | 4 | 118470 | 18692 | 64361566 |
Pigmentation disorder | 21.72 | 15.31 | 34 | 118440 | 4578 | 64375680 |
Fingerprint loss | 21.62 | 15.31 | 7 | 118467 | 58 | 64380200 |
Metastases to muscle | 21.62 | 15.31 | 11 | 118463 | 315 | 64379943 |
Blood pressure diastolic decreased | 21.60 | 15.31 | 7 | 118467 | 22294 | 64357964 |
Premature delivery | 21.57 | 15.31 | 4 | 118470 | 18585 | 64361673 |
Eczema | 21.55 | 15.31 | 14 | 118460 | 29706 | 64350552 |
Cardiospasm | 21.45 | 15.31 | 6 | 118468 | 28 | 64380230 |
Hand-foot-genital syndrome | 21.38 | 15.31 | 5 | 118469 | 9 | 64380249 |
Pain in jaw | 21.38 | 15.31 | 26 | 118448 | 40729 | 64339529 |
Musculoskeletal pain | 21.35 | 15.31 | 77 | 118397 | 81217 | 64299041 |
Hypersomnia | 21.32 | 15.31 | 5 | 118469 | 19712 | 64360546 |
Limbic encephalitis | 21.25 | 15.31 | 14 | 118460 | 657 | 64379601 |
Gallbladder disorder | 21.25 | 15.31 | 3 | 118471 | 17027 | 64363231 |
Aortitis | 21.22 | 15.31 | 17 | 118457 | 1084 | 64379174 |
Gait inability | 21.21 | 15.31 | 28 | 118446 | 42340 | 64337918 |
Hepatic vein stenosis | 21.21 | 15.31 | 7 | 118467 | 62 | 64380196 |
Prostatic calcification | 21.21 | 15.31 | 7 | 118467 | 62 | 64380196 |
Abdominal wall oedema | 21.21 | 15.31 | 4 | 118470 | 0 | 64380258 |
Hallucination, auditory | 21.10 | 15.31 | 3 | 118471 | 16936 | 64363322 |
Cardiac ventricular disorder | 21.09 | 15.31 | 11 | 118463 | 332 | 64379926 |
Hepatic infarction | 21.08 | 15.31 | 15 | 118459 | 799 | 64379459 |
Cachexia | 21.08 | 15.31 | 50 | 118424 | 9167 | 64371091 |
Ischiorectal hernia | 21.03 | 15.31 | 5 | 118469 | 10 | 64380248 |
Cerebrovascular accident | 21.02 | 15.31 | 157 | 118317 | 137426 | 64242832 |
Colitis ulcerative | 20.98 | 15.31 | 8 | 118466 | 23020 | 64357238 |
Rectal cancer metastatic | 20.96 | 15.31 | 12 | 118462 | 437 | 64379821 |
Loss of consciousness | 20.95 | 15.31 | 386 | 118088 | 147979 | 64232279 |
Adverse event | 20.92 | 15.31 | 25 | 118449 | 39464 | 64340794 |
Protein urine | 20.82 | 15.31 | 18 | 118456 | 1276 | 64378982 |
Ventricular fibrillation | 20.81 | 15.31 | 93 | 118381 | 23767 | 64356491 |
Implant site dehiscence | 20.79 | 15.31 | 6 | 118468 | 32 | 64380226 |
Tremor | 20.71 | 15.31 | 385 | 118089 | 147845 | 64232413 |
Swelling face | 20.66 | 15.31 | 49 | 118425 | 59117 | 64321141 |
Blood potassium increased | 20.59 | 15.31 | 11 | 118463 | 25969 | 64354289 |
Hemiparaesthesia | 20.51 | 15.31 | 8 | 118466 | 119 | 64380139 |
Chronic myeloid leukaemia | 20.43 | 15.31 | 28 | 118446 | 3346 | 64376912 |
Hypocapnia | 20.38 | 15.31 | 13 | 118461 | 577 | 64379681 |
Congestive cardiomyopathy | 20.38 | 15.31 | 53 | 118421 | 10291 | 64369967 |
Gout | 20.25 | 15.31 | 7 | 118467 | 21406 | 64358852 |
Fistula | 20.25 | 15.31 | 51 | 118423 | 9710 | 64370548 |
Drug eruption | 20.09 | 15.31 | 22 | 118452 | 36114 | 64344144 |
Musculoskeletal discomfort | 20.00 | 15.31 | 3 | 118471 | 16274 | 64363984 |
Diaphragmatic paralysis | 20.00 | 15.31 | 16 | 118458 | 1018 | 64379240 |
Cholelithiasis | 19.93 | 15.31 | 33 | 118441 | 45473 | 64334785 |
Seizure | 19.93 | 15.31 | 203 | 118271 | 166689 | 64213569 |
Skin disorder | 19.87 | 15.31 | 102 | 118372 | 27578 | 64352680 |
Hiatus hernia | 19.80 | 15.31 | 6 | 118468 | 19951 | 64360307 |
Vocal cord paralysis | 19.77 | 15.31 | 22 | 118452 | 2124 | 64378134 |
Peripheral ischaemia | 19.76 | 15.31 | 46 | 118428 | 8332 | 64371926 |
Toothache | 19.75 | 15.31 | 4 | 118470 | 17455 | 64362803 |
Catheter site bruise | 19.73 | 15.31 | 10 | 118464 | 284 | 64379974 |
Tumour haemorrhage | 19.67 | 15.31 | 28 | 118446 | 3465 | 64376793 |
Pneumonitis | 19.64 | 15.31 | 159 | 118315 | 50206 | 64330052 |
Peripheral sensorimotor neuropathy | 19.64 | 15.31 | 24 | 118450 | 2561 | 64377697 |
Palpitations | 19.63 | 15.31 | 112 | 118362 | 104376 | 64275882 |
Labelled drug-drug interaction medication error | 19.55 | 15.31 | 8 | 118466 | 22054 | 64358204 |
Gastric disorder | 19.53 | 15.31 | 15 | 118459 | 29182 | 64351076 |
Macroglossia | 19.49 | 15.31 | 16 | 118458 | 1056 | 64379202 |
Mucosal disorder | 19.43 | 15.31 | 26 | 118448 | 3036 | 64377222 |
Pseudocirrhosis | 19.33 | 15.31 | 13 | 118461 | 632 | 64379626 |
Oesophagobronchial fistula | 19.26 | 15.31 | 9 | 118465 | 213 | 64380045 |
Delirium | 19.21 | 15.31 | 64 | 118410 | 69130 | 64311128 |
Dry skin | 19.14 | 15.31 | 160 | 118314 | 51001 | 64329257 |
Infusion site hypoaesthesia | 19.13 | 15.31 | 5 | 118469 | 17 | 64380241 |
Anger | 19.12 | 15.31 | 3 | 118471 | 15738 | 64364520 |
Pulmonary congestion | 19.08 | 15.31 | 10 | 118464 | 23870 | 64356388 |
Metastases to diaphragm | 19.05 | 15.31 | 6 | 118468 | 45 | 64380213 |
Skin discolouration | 19.01 | 15.31 | 22 | 118452 | 35233 | 64345025 |
Therapeutic response unexpected | 19.01 | 15.31 | 4 | 118470 | 16997 | 64363261 |
Chemotherapy cardiotoxicity attenuation | 18.91 | 15.31 | 5 | 118469 | 18 | 64380240 |
Hyperthyroidism | 18.90 | 15.31 | 5 | 118469 | 18174 | 64362084 |
Malaise | 18.83 | 15.31 | 899 | 117575 | 395348 | 63984910 |
Monocytopenia | 18.82 | 15.31 | 8 | 118466 | 150 | 64380108 |
Anal sphincter atony | 18.78 | 15.31 | 10 | 118464 | 315 | 64379943 |
Induration | 18.77 | 15.31 | 19 | 118455 | 1645 | 64378613 |
Pneumoperitoneum | 18.73 | 15.31 | 24 | 118450 | 2687 | 64377571 |
Device related infection | 18.71 | 15.31 | 108 | 118366 | 30518 | 64349740 |
No adverse event | 18.69 | 15.31 | 15 | 118459 | 28546 | 64351712 |
Catabolic state | 18.67 | 15.31 | 7 | 118467 | 93 | 64380165 |
Depressed mood | 18.66 | 15.31 | 29 | 118445 | 40983 | 64339275 |
Soft tissue necrosis | 18.57 | 15.31 | 13 | 118461 | 675 | 64379583 |
Musculoskeletal disorder | 18.48 | 15.31 | 5 | 118469 | 17901 | 64362357 |
Neonatal asphyxia | 18.44 | 15.31 | 4 | 118470 | 4 | 64380254 |
Intrahepatic portal hepatic venous fistula | 18.44 | 15.31 | 4 | 118470 | 4 | 64380254 |
Inferior vena cava stenosis | 18.40 | 15.31 | 6 | 118468 | 51 | 64380207 |
Pachymeningitis | 18.34 | 15.31 | 9 | 118465 | 238 | 64380020 |
Rectal cancer recurrent | 18.30 | 15.31 | 5 | 118469 | 21 | 64380237 |
Impaired work ability | 18.26 | 15.31 | 3 | 118471 | 15216 | 64365042 |
Venoocclusive disease | 18.25 | 15.31 | 29 | 118445 | 3956 | 64376302 |
Pancreatic neuroendocrine tumour metastatic | 18.21 | 15.31 | 7 | 118467 | 100 | 64380158 |
Colorectal cancer recurrent | 18.19 | 15.31 | 6 | 118468 | 53 | 64380205 |
Therapy interrupted | 18.19 | 15.31 | 7 | 118467 | 20029 | 64360229 |
Liver function test increased | 18.18 | 15.31 | 18 | 118456 | 30952 | 64349306 |
Impaired healing | 18.15 | 15.31 | 54 | 118420 | 60419 | 64319839 |
Cerebral haemorrhage | 18.09 | 15.31 | 42 | 118432 | 51048 | 64329210 |
Microangiopathic haemolytic anaemia | 18.08 | 15.31 | 17 | 118457 | 1345 | 64378913 |
Mental impairment | 17.96 | 15.31 | 4 | 118470 | 16339 | 64363919 |
Heart rate increased | 17.88 | 15.31 | 107 | 118367 | 98568 | 64281690 |
Tetany | 17.87 | 15.31 | 21 | 118453 | 2151 | 64378107 |
Metastases to ovary | 17.84 | 15.31 | 9 | 118465 | 253 | 64380005 |
Pruritus | 17.76 | 15.31 | 722 | 117752 | 311678 | 64068580 |
Venous injury | 17.72 | 15.31 | 12 | 118462 | 590 | 64379668 |
Cerebral vasoconstriction | 17.67 | 15.31 | 16 | 118458 | 1206 | 64379052 |
Amnesia | 17.64 | 15.31 | 39 | 118435 | 48230 | 64332028 |
Immunodeficiency | 17.61 | 15.31 | 4 | 118470 | 16120 | 64364138 |
Endometrial dysplasia | 17.60 | 15.31 | 5 | 118469 | 25 | 64380233 |
Abdominal abscess | 17.57 | 15.31 | 37 | 118437 | 6267 | 64373991 |
Splenic abscess | 17.56 | 15.31 | 11 | 118463 | 473 | 64379785 |
Blood creatinine increased | 17.54 | 15.31 | 162 | 118312 | 135620 | 64244638 |
Radiation interaction | 17.53 | 15.31 | 6 | 118468 | 60 | 64380198 |
Tunnel vision | 17.51 | 15.31 | 15 | 118459 | 1050 | 64379208 |
Metastases to retroperitoneum | 17.49 | 15.31 | 10 | 118464 | 363 | 64379895 |
Product administration error | 17.49 | 15.31 | 15 | 118459 | 27628 | 64352630 |
Extrapyramidal disorder | 17.47 | 15.31 | 7 | 118467 | 19545 | 64360713 |
Gastrointestinal obstruction | 17.43 | 15.31 | 17 | 118457 | 1408 | 64378850 |
VIth nerve disorder | 17.28 | 15.31 | 5 | 118469 | 27 | 64380231 |
Disease recurrence | 17.26 | 15.31 | 108 | 118366 | 31402 | 64348856 |
Restless legs syndrome | 17.25 | 15.31 | 5 | 118469 | 17111 | 64363147 |
Chronic kidney disease | 17.18 | 15.31 | 52 | 118422 | 57867 | 64322391 |
Gastrointestinal necrosis | 17.17 | 15.31 | 32 | 118442 | 4960 | 64375298 |
Aortic intramural haematoma | 17.15 | 15.31 | 7 | 118467 | 118 | 64380140 |
Motion sickness | 17.13 | 15.31 | 13 | 118461 | 765 | 64379493 |
Peripheral nerve injury | 17.12 | 15.31 | 12 | 118462 | 624 | 64379634 |
Renal disorder | 17.07 | 15.31 | 24 | 118450 | 35341 | 64344917 |
Gastrointestinal mucosal necrosis | 16.98 | 15.31 | 8 | 118466 | 193 | 64380065 |
Atrioventricular block complete | 16.95 | 15.31 | 3 | 118471 | 14415 | 64365843 |
Sciatica | 16.93 | 15.31 | 8 | 118466 | 20256 | 64360002 |
Nephritis allergic | 16.92 | 15.31 | 12 | 118462 | 636 | 64379622 |
Night sweats | 16.87 | 15.31 | 25 | 118449 | 36021 | 64344237 |
Autoimmune haemolytic anaemia | 16.85 | 15.31 | 39 | 118435 | 7037 | 64373221 |
Mixed adenoneuroendocrine carcinoma | 16.83 | 15.31 | 4 | 118470 | 8 | 64380250 |
Eye pain | 16.77 | 15.31 | 20 | 118454 | 31605 | 64348653 |
Therapy cessation | 16.75 | 15.31 | 21 | 118453 | 32468 | 64347790 |
Ichthyosis | 16.73 | 15.31 | 7 | 118467 | 126 | 64380132 |
Amaurosis fugax | 16.71 | 15.31 | 13 | 118461 | 794 | 64379464 |
Post embolisation syndrome | 16.70 | 15.31 | 6 | 118468 | 70 | 64380188 |
Gastric varices | 16.65 | 15.31 | 11 | 118463 | 519 | 64379739 |
Laboratory test abnormal | 16.56 | 15.31 | 12 | 118462 | 24051 | 64356207 |
Lacrimation disorder | 16.51 | 15.31 | 4 | 118470 | 9 | 64380249 |
Blood triglycerides increased | 16.46 | 15.31 | 7 | 118467 | 18859 | 64361399 |
Oesophageal fistula | 16.39 | 15.31 | 9 | 118465 | 302 | 64379956 |
Fixed eruption | 16.33 | 15.31 | 20 | 118454 | 2139 | 64378119 |
Adenocarcinoma of colon | 16.31 | 15.31 | 31 | 118443 | 4877 | 64375381 |
Aplasia | 16.21 | 15.31 | 38 | 118436 | 6915 | 64373343 |
Aplastic anaemia | 16.14 | 15.31 | 3 | 118471 | 13917 | 64366341 |
Feeling cold | 16.13 | 15.31 | 86 | 118388 | 23592 | 64356666 |
Lymphadenopathy mediastinal | 16.11 | 15.31 | 27 | 118447 | 3849 | 64376409 |
Infection | 15.98 | 15.31 | 241 | 118233 | 184639 | 64195619 |
Eyelid ptosis | 15.97 | 15.31 | 46 | 118428 | 9479 | 64370779 |
Mental disorder | 15.95 | 15.31 | 15 | 118459 | 26430 | 64353828 |
Dyskinesia | 15.95 | 15.31 | 30 | 118444 | 39358 | 64340900 |
Neuronal neuropathy | 15.91 | 15.31 | 3 | 118471 | 0 | 64380258 |
Gastrointestinal stoma output increased | 15.82 | 15.31 | 8 | 118466 | 226 | 64380032 |
Coombs positive haemolytic anaemia | 15.74 | 15.31 | 13 | 118461 | 865 | 64379393 |
Subdural haematoma | 15.68 | 15.31 | 17 | 118457 | 28037 | 64352221 |
Tumour marker increased | 15.65 | 15.31 | 25 | 118449 | 3425 | 64376833 |
Lymphangiosis carcinomatosa | 15.64 | 15.31 | 18 | 118456 | 1803 | 64378455 |
Oedema | 15.47 | 15.31 | 102 | 118372 | 91833 | 64288425 |
Myoclonus | 15.45 | 15.31 | 14 | 118460 | 25104 | 64355154 |
Liver injury | 15.41 | 15.31 | 101 | 118373 | 29831 | 64350427 |
Abdominal sepsis | 15.41 | 15.31 | 18 | 118456 | 1832 | 64378426 |
Ankle fracture | 15.38 | 15.31 | 4 | 118470 | 14706 | 64365552 |
Sense of oppression | 15.38 | 15.31 | 16 | 118458 | 1431 | 64378827 |
None
Source | Code | Description |
---|---|---|
ATC | L01XA03 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Platinum compounds |
FDA EXT | N0000175073 | Platinum-containing Compounds |
FDA EPC | N0000175413 | Platinum-based Drug |
MeSH PA | D000970 | Antineoplastic Agents |
CHEBI has role | CHEBI:25435 | mutagens |
CHEBI has role | CHEBI:35610 | antineoplastic agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Metastasis from malignant tumor of colon | indication | 314998002 | |
Small intestine cancer | indication | 363509000 | DOID:10154 |
Lymph Node Positive Colorectal Carcinoma | indication | ||
Malignant tumor of colon | off-label use | 363406005 | DOID:219 |
Malignant tumor of testis | off-label use | 363449006 | DOID:2998 |
Adenocarcinoma of pancreas | off-label use | 700423003 | DOID:4074 |
Fibrosis of lung | contraindication | 51615001 | DOID:3770 |
Interstitial pneumonia | contraindication | 64667001 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Liver function tests abnormal | contraindication | 166603001 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Pregnancy, function | contraindication | 289908002 | |
Peripheral nerve disease | contraindication | 302226006 | |
Breastfeeding (mother) | contraindication | 413712001 |
None
None
None
None
None
None
ID | Source |
---|---|
4021355 | VUID |
N0000148774 | NUI |
D01790 | KEGG_DRUG |
4021355 | VANDF |
C0069717 | UMLSCUI |
CHEBI:31941 | CHEBI |
1PT | PDB_CHEM_ID |
CHEMBL414804 | ChEMBL_ID |
D000077150 | MESH_DESCRIPTOR_UI |
DB00526 | DRUGBANK_ID |
7433 | IUPHAR_LIGAND_ID |
6012 | INN_ID |
04ZR38536J | UNII |
9887053 | PUBCHEM_CID |
32592 | RXNORM |
165344 | MMSL |
16916 | MMSL |
d04811 | MMSL |
007166 | NDDF |
327032007 | SNOMEDCT_US |
395814003 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-3985 | INJECTION, SOLUTION, CONCENTRATE | 50 mg | INTRAVENOUS | NDA | 28 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-3986 | INJECTION, SOLUTION, CONCENTRATE | 100 mg | INTRAVENOUS | NDA | 28 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3315 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 29 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3317 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 29 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-9315 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 28 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-9317 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 28 sections |
OXALIPLATIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1725 | INJECTION, SOLUTION, CONCENTRATE | 5 mg | INTRAVENOUS | NDA AUTHORIZED GENERIC | 33 sections |
OXALIPLATIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1727 | INJECTION, SOLUTION, CONCENTRATE | 5 mg | INTRAVENOUS | NDA AUTHORIZED GENERIC | 33 sections |
OXALIPLATIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1731 | INJECTION, SOLUTION, CONCENTRATE | 5 mg | INTRAVENOUS | NDA AUTHORIZED GENERIC | 33 sections |
OXALIPLATIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1733 | INJECTION, SOLUTION, CONCENTRATE | 5 mg | INTRAVENOUS | NDA AUTHORIZED GENERIC | 33 sections |
oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-727 | INJECTION | 5 mg | INTRAVENOUS | ANDA | 27 sections |
oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-728 | INJECTION | 5 mg | INTRAVENOUS | ANDA | 27 sections |
oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-332 | INJECTION, SOLUTION, CONCENTRATE | 5 mg | INTRAVENOUS | ANDA | 30 sections |
oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-233 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 28 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43066-014 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 28 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43066-018 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 28 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45963-611 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 5 mg | INTRAVENOUS | ANDA | 20 sections |
Oxaliplatin | Human Prescription Drug Label | 1 | 47335-046 | INJECTION, SOLUTION, CONCENTRATE | 50 mg | INTRAVENOUS | ANDA | 27 sections |
Oxaliplatin | Human Prescription Drug Label | 1 | 47335-047 | INJECTION, SOLUTION, CONCENTRATE | 100 mg | INTRAVENOUS | ANDA | 27 sections |
Oxaliplatin | Human Prescription Drug Label | 1 | 47335-176 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 50 mg | INTRAVENOUS | ANDA | 28 sections |
Oxaliplatin | Human Prescription Drug Label | 1 | 47335-178 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 100 mg | INTRAVENOUS | ANDA | 28 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50742-405 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 26 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50742-406 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | ANDA | 26 sections |
Oxaliplatin | Human Prescription Drug Label | 1 | 55150-331 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 29 sections |
Oxaliplatin | Human Prescription Drug Label | 1 | 55150-332 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 29 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 57277-001 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 26 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 57277-002 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 26 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6132 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 25 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6132 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 25 sections |
Oxaliplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61703-363 | INJECTION, SOLUTION, CONCENTRATE | 5 mg | INTRAVENOUS | ANDA | 33 sections |