oxaliplatin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antineoplastic agents, platinum derivatives	4210	61825-94-3

Description:

Molecule	Description
Synonyms: oxaliplatin oxalatoplatin oxalatoplatinum elplat	An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS. Molecular weight: 397.29 Formula: C8H14N2O4Pt CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

oxaliplatin
oxalatoplatin
oxalatoplatinum
elplat

An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS.

Molecular weight: 397.29
Formula: C8H14N2O4Pt
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	6 mg/mL	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	8.13 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution)	0.50 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	0.10 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.13 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	58.92 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Aug. 9, 2002	FDA
March 18, 2005	PMDA	Yakult Honsha

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Neuropathy peripheral	1285.89	17.12	1010	64656	112657	63310699
Neutropenia	1103.53	17.12	1117	64549	173888	63249468
Disease progression	1081.93	17.12	944	64722	121814	63301542
Laryngospasm	1036.03	17.12	292	65374	2736	63420620
Neurotoxicity	809.71	17.12	381	65285	16609	63406747
Thrombocytopenia	780.11	17.12	868	64798	150289	63273067
Diarrhoea	625.95	17.12	1883	63783	713483	62709873
Mucosal inflammation	505.87	17.12	406	65260	46522	63376834
Palmar-plantar erythrodysaesthesia syndrome	482.03	17.12	299	65367	22716	63400640
Paraesthesia	468.52	17.12	687	64979	156279	63267077
Vomiting	448.70	17.12	1431	64235	558186	62865170
Myelosuppression	400.33	17.12	269	65397	23434	63399922
Stridor	364.17	17.12	137	65529	3373	63419983
Dermatitis acneiform	363.94	17.12	151	65515	4845	63418511
Polyneuropathy	353.07	17.12	208	65458	14381	63408975
Dysarthria	336.77	17.12	309	65357	42402	63380954
Arthralgia	328.29	17.12	92	65574	569618	62853738
Bone marrow failure	327.47	17.12	259	65407	29031	63394325
Peripheral sensory neuropathy	327.12	17.12	158	65508	7293	63416063
Arteriospasm coronary	319.99	17.12	129	65537	3839	63419517
Bronchospasm	303.56	17.12	201	65465	17079	63406277
Throat tightness	299.76	17.12	230	65436	24657	63398699
Nausea	296.40	17.12	1693	63973	852778	62570578
Skin toxicity	292.00	17.12	127	65539	4587	63418769
Dysaesthesia pharynx	276.89	17.12	57	65609	101	63423255
Joint swelling	271.82	17.12	17	65649	327649	63095707
Febrile neutropenia	254.90	17.12	447	65219	118002	63305354
Malignant neoplasm progression	249.78	17.12	363	65303	81758	63341598
Drug ineffective	240.34	17.12	449	65217	1044316	62379040
Metastases to liver	238.74	17.12	197	65469	23442	63399914
Haematotoxicity	230.33	17.12	135	65531	9241	63414115
Non-cirrhotic portal hypertension	225.98	17.12	52	65614	189	63423167
Arthropathy	222.85	17.12	4	65662	234788	63188568
Pain	217.41	17.12	269	65397	740359	62682997
Leukopenia	205.63	17.12	321	65345	76969	63346387
Gastrointestinal toxicity	204.88	17.12	117	65549	7624	63415732
Swelling	204.47	17.12	23	65643	275355	63148001
Headache	201.95	17.12	215	65451	633026	62790330
Product dose omission issue	200.88	17.12	10	65656	234303	63189053
Sinusitis	199.79	17.12	8	65658	226645	63196711
Contraindicated product administered	194.18	17.12	7	65659	217641	63205715
Systemic lupus erythematosus	192.59	17.12	5	65661	208913	63214443
Gastrointestinal perforation	190.32	17.12	86	65580	3405	63419951
Neutrophil count decreased	187.19	17.12	260	65406	56146	63367210
Paronychia	185.63	17.12	98	65568	5467	63417889
Posterior reversible encephalopathy syndrome	184.49	17.12	149	65517	17196	63406160
Dyspnoea	183.48	17.12	1239	64427	660074	62763282
Nasopharyngitis	181.96	17.12	24	65642	254233	63169123
Enteritis	181.95	17.12	111	65555	8175	63415181
Pemphigus	174.85	17.12	3	65663	183723	63239633
Erythema	171.48	17.12	483	65183	175268	63248088
Portal hypertension	170.70	17.12	82	65584	3737	63419619
Weight increased	163.68	17.12	35	65631	260757	63162599
Abdominal discomfort	161.46	17.12	65	65601	320820	63102536
Glossodynia	158.68	17.12	6	65660	178870	63244486
Therapeutic product effect decreased	151.56	17.12	13	65653	193174	63230182
Maternal exposure during pregnancy	147.70	17.12	25	65641	220037	63203319
Dehydration	144.87	17.12	451	65215	172903	63250453
Peripheral swelling	143.66	17.12	48	65618	265894	63157462
Anaphylactic shock	143.09	17.12	148	65518	23485	63399871
Wound	143.04	17.12	6	65660	163257	63260099
Laryngeal oedema	139.57	17.12	82	65584	5636	63417720
Hyperammonaemia	138.25	17.12	79	65587	5153	63418203
Abdominal pain	137.36	17.12	634	65032	292822	63130534
Fall	135.39	17.12	124	65542	392210	63031146
Ascites	134.00	17.12	187	65479	40541	63382815
Product use issue	133.53	17.12	32	65634	220488	63202868
Venoocclusive liver disease	130.43	17.12	74	65592	4761	63418595
Anaemia	130.06	17.12	624	65042	292806	63130550
Therapy partial responder	129.40	17.12	99	65567	10559	63412797
Chills	125.95	17.12	327	65339	113051	63310305
Enterocolitis	125.06	17.12	86	65580	7772	63415584
Asthenia	124.00	17.12	748	64918	382856	63040500
Colorectal cancer metastatic	122.30	17.12	39	65627	574	63422782
Depression	121.97	17.12	27	65639	196465	63226891
Lower respiratory tract infection	115.43	17.12	5	65661	132302	63291054
Splenomegaly	114.76	17.12	94	65572	11063	63412293
Asthma	114.08	17.12	4	65662	127557	63295799
Neoplasm progression	113.54	17.12	163	65503	36265	63387091
Immune thrombocytopenia	112.93	17.12	91	65575	10465	63412891
Dysphonia	110.57	17.12	186	65480	47428	63375928
Tongue oedema	109.92	17.12	65	65601	4521	63418835
Pericarditis	108.45	17.12	7	65659	131572	63291784
Hypokalaemia	105.78	17.12	290	65376	103514	63319842
Nodular regenerative hyperplasia	104.28	17.12	33	65633	473	63422883
Musculoskeletal stiffness	103.79	17.12	31	65635	184587	63238769
Hepatic enzyme increased	103.30	17.12	40	65626	202288	63221068
Bronchitis	101.92	17.12	7	65659	124928	63298428
Cardiotoxicity	101.60	17.12	78	65588	8360	63414996
Intestinal perforation	101.00	17.12	90	65576	11873	63411483
Dysaesthesia	100.91	17.12	61	65605	4417	63418939
Flushing	99.74	17.12	232	65434	74855	63348501
Insomnia	99.69	17.12	49	65617	215203	63208153
Metastases to peritoneum	99.15	17.12	55	65611	3387	63419969
Hypomagnesaemia	99.11	17.12	135	65531	28602	63394754
Large intestine perforation	96.90	17.12	76	65590	8406	63414950
Drug intolerance	96.73	17.12	106	65560	308555	63114801
Metastases to lung	96.08	17.12	90	65576	12660	63410696
Hyperammonaemic encephalopathy	96.04	17.12	48	65618	2386	63420970
Intestinal obstruction	95.91	17.12	138	65528	30761	63392595
Dysphagia	94.78	17.12	252	65414	88333	63335023
Hyperthermia	93.87	17.12	77	65589	9079	63414277
Anastomotic leak	93.73	17.12	30	65636	447	63422909
Paraesthesia oral	92.87	17.12	107	65559	19149	63404207
Focal nodular hyperplasia	92.38	17.12	31	65635	540	63422816
Speech disorder	92.06	17.12	157	65509	40472	63382884
Influenza	88.95	17.12	6	65660	108716	63314640
Contusion	88.41	17.12	23	65643	150021	63273335
General physical health deterioration	88.16	17.12	427	65239	200975	63222381
Pain in extremity	88.11	17.12	129	65537	331357	63091999
Decreased appetite	87.72	17.12	500	65166	250552	63172804
Exposure during pregnancy	87.63	17.12	26	65640	155521	63267835
Arthritis	85.15	17.12	10	65656	115911	63307445
Neuromyotonia	82.97	17.12	18	65648	46	63423310
Helicobacter infection	82.64	17.12	3	65663	92782	63330574
Psoriatic arthropathy	81.37	17.12	3	65663	91517	63331839
Alopecia	80.61	17.12	141	65525	337395	63085961
Injection site pain	80.19	17.12	18	65648	129782	63293574
Platelet count decreased	79.86	17.12	283	65383	115839	63307517
Treatment failure	79.78	17.12	54	65612	198989	63224367
Interstitial lung disease	79.72	17.12	189	65477	61719	63361637
Stress cardiomyopathy	77.62	17.12	70	65596	9380	63413976
Condition aggravated	77.50	17.12	190	65476	402027	63021329
Duodenal ulcer perforation	77.05	17.12	3	65663	87206	63336150
Ileus	76.42	17.12	85	65581	14640	63408716
Tachycardia	75.37	17.12	281	65385	117875	63305481
Discomfort	74.65	17.12	40	65626	167334	63256022
Drug hypersensitivity	73.97	17.12	130	65536	310557	63112799
Hyperhidrosis	72.61	17.12	261	65405	107575	63315781
Hospitalisation	71.69	17.12	4	65662	85077	63338279
Laryngeal discomfort	70.33	17.12	22	65644	303	63423053
Anaphylactic reaction	69.64	17.12	187	65479	65913	63357443
Hypertensive crisis	68.82	17.12	82	65584	15204	63408152
Stomatitis	68.68	17.12	305	65361	138420	63284936
Metastases to meninges	67.97	17.12	39	65627	2563	63420793
Band sensation	65.65	17.12	27	65639	846	63422510
Laryngeal dyspnoea	64.48	17.12	18	65648	162	63423194
Haemolytic anaemia	64.16	17.12	65	65601	10060	63413296
Acute coronary syndrome	64.16	17.12	65	65601	10061	63413295
Injection site erythema	64.10	17.12	6	65660	83168	63340188
Injury	63.11	17.12	3	65663	73244	63350112
Metastases to ovary	62.92	17.12	22	65644	436	63422920
Oxygen saturation decreased	62.71	17.12	218	65448	88367	63334989
Gastric varices haemorrhage	62.34	17.12	17	65649	139	63423217
Tumour perforation	61.87	17.12	16	65650	104	63423252
Cholinergic syndrome	60.27	17.12	22	65644	496	63422860
Pyrexia	59.87	17.12	746	64920	469732	62953624
Peritonitis	59.77	17.12	81	65585	17073	63406283
Blister	59.39	17.12	30	65636	129784	63293572
Drug abuse	59.32	17.12	4	65662	72514	63350842
Neutropenic colitis	59.23	17.12	38	65628	3057	63420299
Off label use	59.15	17.12	1002	64664	673460	62749896
Colitis	59.09	17.12	145	65521	48383	63374973
Cardiac failure congestive	58.75	17.12	12	65654	92421	63330935
Varices oesophageal	58.64	17.12	38	65628	3110	63420246
Cytokine release syndrome	56.71	17.12	72	65594	14242	63409114
Pancytopenia	56.45	17.12	224	65442	96709	63326647
Upper respiratory tract infection	55.71	17.12	9	65657	82038	63341318
Mobility decreased	53.94	17.12	29	65637	121130	63302226
Diffuse large B-cell lymphoma refractory	53.73	17.12	26	65640	1204	63422152
Enterocutaneous fistula	53.50	17.12	27	65639	1370	63421986
Chemical peritonitis	53.24	17.12	14	65652	98	63423258
Infusion related hypersensitivity reaction	53.19	17.12	17	65649	252	63423104
Somnolence	53.05	17.12	64	65602	178621	63244735
Suicidal ideation	52.38	17.12	3	65663	62418	63360938
Disseminated intravascular coagulation	51.83	17.12	80	65586	18971	63404385
Migraine	51.77	17.12	21	65645	103325	63320031
Stress	51.34	17.12	5	65661	67162	63356194
Mucosal toxicity	51.28	17.12	18	65648	361	63422995
Fatigue	51.23	17.12	631	65035	887397	62535959
Type I hypersensitivity	51.11	17.12	34	65632	2908	63420448
Suicide attempt	50.90	17.12	3	65663	60915	63362441
Intentional product misuse	50.90	17.12	3	65663	60914	63362442
Type 2 diabetes mellitus	50.87	17.12	4	65662	63864	63359492
Feeling hot	50.58	17.12	140	65526	50214	63373142
Tachypnoea	50.39	17.12	75	65591	17227	63406129
Extravasation	50.09	17.12	31	65635	2341	63421015
Fluid retention	49.69	17.12	3	65663	59683	63363673
Folliculitis	49.38	17.12	7	65659	70310	63353046
Evans syndrome	48.60	17.12	15	65651	197	63423159
White blood cell count decreased	48.47	17.12	277	65389	138827	63284529
Rectal perforation	48.46	17.12	18	65648	427	63422929
Memory impairment	47.83	17.12	24	65642	104234	63319122
Hypertension	47.40	17.12	469	65197	278834	63144522
Proteinuria	47.40	17.12	77	65589	19068	63404288
Cataract	47.10	17.12	3	65663	57050	63366306
Dysgeusia	47.05	17.12	130	65536	46580	63376776
Dihydropyrimidine dehydrogenase deficiency	46.95	17.12	12	65654	74	63423282
Ocular toxicity	46.83	17.12	20	65646	690	63422666
Sensation of foreign body	46.75	17.12	39	65627	4706	63418650
Inappropriate schedule of product administration	46.11	17.12	25	65641	103940	63319416
Hepatic failure	46.04	17.12	109	65557	35547	63387809
Hydronephrosis	46.04	17.12	56	65610	10606	63412750
Pneumonia	45.72	17.12	281	65385	456486	62966870
Injection site reaction	45.69	17.12	4	65662	58520	63364836
Diffuse large B-cell lymphoma recurrent	45.67	17.12	29	65637	2291	63421065
Anxiety	45.67	17.12	98	65568	217443	63205913
Choking sensation	45.32	17.12	34	65632	3520	63419836
Gait disturbance	45.06	17.12	75	65591	183103	63240253
Leukoencephalopathy	45	17.12	37	65629	4376	63418980
Carcinoembryonic antigen increased	44.89	17.12	26	65640	1739	63421617
Osteoporosis	44.54	17.12	4	65662	57334	63366022
Pharyngeal paraesthesia	44.32	17.12	27	65639	1982	63421374
Drug interaction	44.24	17.12	108	65558	229023	63194333
Sleep disorder	43.49	17.12	15	65651	81551	63341805
Oropharyngeal discomfort	43.27	17.12	39	65627	5221	63418135
Suffocation feeling	42.84	17.12	23	65643	1327	63422029
Overdose	42.48	17.12	34	65632	115044	63308312
Neutrophil count abnormal	42.16	17.12	30	65636	2862	63420494
Metastasis	41.70	17.12	38	65628	5159	63418197
Trichomegaly	41.59	17.12	11	65655	79	63423277
Cold dysaesthesia	41.46	17.12	8	65658	8	63423348
Splenic artery thrombosis	41.40	17.12	10	65656	47	63423309
Factor VII deficiency	40.94	17.12	9	65657	25	63423331
Muscle spasms	40.80	17.12	289	65377	155861	63267495
Blood lactate dehydrogenase abnormal	40.22	17.12	15	65651	360	63422996
Lymphoma	40.13	17.12	56	65610	12131	63411225
Chronic obstructive pulmonary disease	40.12	17.12	8	65658	62678	63360678
Skin fissures	40.02	17.12	54	65612	11334	63412022
Anastomotic fistula	39.48	17.12	9	65657	31	63423325
Thrombocytopenic purpura	39.44	17.12	22	65644	1369	63421987
Metastases to spleen	39.14	17.12	12	65654	154	63423202
Steatohepatitis	38.82	17.12	17	65649	624	63422732
Pharyngeal dyskinesia	38.43	17.12	9	65657	36	63423320
Cystitis radiation	38.03	17.12	10	65656	70	63423286
Septic shock	38.00	17.12	153	65513	66476	63356880
Congestive cardiomyopathy	37.92	17.12	39	65627	6143	63417213
Bladder tamponade	37.91	17.12	10	65656	71	63423285
Multiple organ dysfunction syndrome	37.86	17.12	137	65529	56615	63366741
Incorrect dose administered	37.66	17.12	8	65658	59960	63363396
Tremor	37.66	17.12	250	65416	131989	63291367
Hypertrichosis	37.57	17.12	20	65646	1134	63422222
Acute polyneuropathy	37.45	17.12	13	65653	252	63423104
Blood lactate dehydrogenase increased	36.99	17.12	77	65589	23039	63400317
Paralysis	36.41	17.12	48	65618	9852	63413504
Cardiac ventricular thrombosis	36.14	17.12	16	65650	603	63422753
Hyperpyrexia	36.09	17.12	30	65636	3602	63419754
Large intestinal obstruction	36.00	17.12	25	65641	2294	63421062
Short-bowel syndrome	35.80	17.12	15	65651	493	63422863
Formication	35.66	17.12	32	65634	4259	63419097
Vascular pain	35.54	17.12	17	65649	767	63422589
Infection	35.45	17.12	120	65546	229053	63194303
Injection site pruritus	35.44	17.12	3	65663	45113	63378243
Cough	35.37	17.12	169	65497	292574	63130782
Hepatic function abnormal	35.08	17.12	101	65565	37041	63386315
Confusional state	35.07	17.12	126	65540	236254	63187102
Abortion spontaneous	34.82	17.12	4	65662	47191	63376165
Inflammation	34.74	17.12	21	65645	82252	63341104
Illness	34.17	17.12	5	65661	49054	63374302
Hypoalbuminaemia	34.13	17.12	51	65615	11754	63411602
Pulmonary embolism	34.07	17.12	222	65444	116462	63306894
Hypertransaminasaemia	34.03	17.12	38	65628	6571	63416785
Ileal perforation	34.00	17.12	14	65652	440	63422916
Blood pressure fluctuation	33.99	17.12	4	65662	46313	63377043
ECG signs of myocardial ischaemia	33.98	17.12	9	65657	65	63423291
Chest discomfort	33.82	17.12	212	65454	109757	63313599
Muscle rigidity	33.70	17.12	50	65616	11450	63411906
Atypical haemolytic uraemic syndrome	33.51	17.12	16	65650	719	63422637
Adverse event	33.39	17.12	14	65652	67545	63355811
Myalgia	33.31	17.12	63	65603	146466	63276890
Gastric perforation	33.08	17.12	21	65645	1658	63421698
Mucosal necrosis	32.88	17.12	8	65658	39	63423317
Rash pustular	32.67	17.12	39	65627	7243	63416113
Thrombotic microangiopathy	32.52	17.12	47	65619	10514	63412842
Impaired healing	32.29	17.12	35	65631	102507	63320849
Palmar erythema	32.10	17.12	21	65645	1746	63421610
Loss of personal independence in daily activities	32	17.12	32	65634	97258	63326098
Perforation	31.62	17.12	18	65648	1165	63422191
Respiratory distress	30.79	17.12	91	65575	33860	63389496
Wrong technique in product usage process	30.68	17.12	13	65653	62327	63361029
Peripheral motor neuropathy	30.59	17.12	20	65646	1661	63421695
Trismus	30.38	17.12	28	65638	3857	63419499
Vocal cord paralysis	30.19	17.12	22	65644	2179	63421177
Autoimmune haemolytic anaemia	30	17.12	30	65636	4571	63418785
Haemolysis	29.96	17.12	36	65630	6732	63416624
Herpes zoster	29.64	17.12	25	65641	82437	63340919
Nicotinic acid deficiency	29.49	17.12	8	65658	64	63423292
Anaphylactoid reaction	29.44	17.12	27	65639	3696	63419660
Motion sickness	29.30	17.12	16	65650	955	63422401
Tumour necrosis	28.96	17.12	15	65651	804	63422552
Hemiparesis	28.79	17.12	70	65596	23212	63400144
Hypotension	28.68	17.12	418	65248	272186	63151170
Tumour ulceration	28.61	17.12	10	65656	198	63423158
Feeling abnormal	28.58	17.12	70	65596	148322	63275034
Influenza like illness	28.29	17.12	17	65649	66807	63356549
Treatment noncompliance	27.95	17.12	3	65663	37322	63386034
Injection site paraesthesia	27.80	17.12	13	65653	557	63422799
Cyanosis	27.79	17.12	57	65609	16878	63406478
Bursitis	27.68	17.12	3	65663	37038	63386318
Haemolytic uraemic syndrome	27.67	17.12	22	65644	2481	63420875
Adverse drug reaction	27.64	17.12	25	65641	79689	63343667
Peripheral nerve injury	27.44	17.12	12	65654	439	63422917
Intentional product use issue	27.34	17.12	57	65609	127835	63295521
Road traffic accident	27.29	17.12	3	65663	36629	63386727
Inferior vena cava stenosis	27.21	17.12	6	65660	17	63423339
Medical device site extravasation	27.03	17.12	5	65661	3	63423353
Subileus	27.00	17.12	24	65642	3155	63420201
Sedation	26.93	17.12	4	65662	38805	63384551
Urinary tract infection	26.86	17.12	162	65504	264522	63158834
Rectal cancer recurrent	26.71	17.12	6	65660	19	63423337
Hypophagia	26.67	17.12	82	65584	31177	63392179
Cytopenia	26.49	17.12	45	65621	11556	63411800
Catheter site bruise	26.46	17.12	12	65654	479	63422877
Post embolisation syndrome	26.44	17.12	5	65661	4	63423352
Left ventricular failure	26.41	17.12	31	65635	5656	63417700
K-ras gene mutation	26.25	17.12	6	65660	21	63423335
Haematemesis	26.15	17.12	80	65586	30332	63393024
Metastases to lymph nodes	26.14	17.12	37	65629	8121	63415235
Hemiparaesthesia	26.00	17.12	8	65658	104	63423252
Rhinorrhoea	25.97	17.12	18	65648	65559	63357797
Tonic clonic movements	25.94	17.12	17	65649	1418	63421938
Schistosomiasis	25.92	17.12	5	65661	5	63423351
Catabolic state	25.69	17.12	7	65659	57	63423299
White blood cell count abnormal	25.68	17.12	32	65634	6210	63417146
Granulocyte count decreased	25.66	17.12	16	65650	1224	63422132
Productive cough	25.50	17.12	17	65649	63191	63360165
Cholangitis	25.31	17.12	30	65636	5531	63417825
Disease recurrence	25.30	17.12	75	65591	27955	63395401
Balance disorder	25.29	17.12	30	65636	84392	63338964
Respiratory failure	25.13	17.12	186	65480	101672	63321684
Heart rate decreased	24.95	17.12	8	65658	45552	63377804
Ileus paralytic	24.87	17.12	27	65639	4524	63418832
Necrotic lymphadenopathy	24.78	17.12	7	65659	66	63423290
Nasal congestion	24.73	17.12	19	65647	65641	63357715
Subacute cutaneous lupus erythematosus	24.55	17.12	21	65645	2622	63420734
COVID-19	24.52	17.12	50	65616	113053	63310303
Lip oedema	24.51	17.12	25	65641	3899	63419457
Hepatocellular injury	24.46	17.12	73	65593	27308	63396048
Dizziness	24.45	17.12	306	65360	429619	62993737
Metastases to diaphragm	24.37	17.12	6	65660	31	63423325
Gastrointestinal anastomotic leak	24.21	17.12	9	65657	214	63423142
Colon cancer metastatic	24.20	17.12	15	65651	1136	63422220
Monoparesis	24.00	17.12	17	65649	1610	63421746
Administration site extravasation	23.97	17.12	14	65652	951	63422405
Sepsis	23.96	17.12	253	65413	152870	63270486
Colorectal cancer recurrent	23.89	17.12	5	65661	10	63423346
Blood glucose increased	23.80	17.12	31	65635	83725	63339631
Small intestinal obstruction	23.61	17.12	56	65610	18281	63405075
Electrolyte imbalance	23.39	17.12	59	65607	20017	63403339
Oral dysaesthesia	23.26	17.12	7	65659	84	63423272
Oesophageal varices haemorrhage	23.24	17.12	15	65651	1219	63422137
Gait inability	23.09	17.12	13	65653	52946	63370410
Colon cancer recurrent	22.89	17.12	7	65659	89	63423267
Weight decreased	22.85	17.12	180	65486	276618	63146738
Aortic intramural haematoma	22.75	17.12	7	65659	91	63423265
Portal shunt	22.72	17.12	5	65661	14	63423342
Implant site dehiscence	22.72	17.12	5	65661	14	63423342
Medication error	22.56	17.12	13	65653	52271	63371085
Myopathy toxic	22.54	17.12	11	65655	519	63422837
Diabetes mellitus	22.52	17.12	15	65651	55795	63367561
Retching	22.52	17.12	48	65618	14597	63408759
Hypocapnia	22.48	17.12	10	65656	381	63422975
Biliary tract infection	22.39	17.12	12	65654	690	63422666
Drug reaction with eosinophilia and systemic symptoms	22.33	17.12	4	65662	33832	63389524
Renal tubular disorder	22.29	17.12	20	65646	2662	63420694
Gastrointestinal stoma complication	22.01	17.12	17	65649	1838	63421518
Type II hypersensitivity	21.99	17.12	5	65661	17	63423339
Viral infection	21.90	17.12	5	65661	35658	63387698
Neutropenic infection	21.84	17.12	15	65651	1352	63422004
Gastrooesophageal reflux disease	21.83	17.12	41	65625	95598	63327758
Toxic leukoencephalopathy	21.63	17.12	12	65654	739	63422617
Swollen tongue	21.53	17.12	82	65584	34718	63388638
Soft tissue necrosis	21.47	17.12	11	65655	576	63422780
Lacrimation disorder	21.27	17.12	4	65662	3	63423353
Cardiogenic shock	21.21	17.12	53	65613	17879	63405477
Colitis ischaemic	21.18	17.12	39	65627	10669	63412687
Therapy interrupted	21.07	17.12	4	65662	32451	63390905
Coronary artery disease	20.99	17.12	4	65662	32373	63390983
Metastases to bone marrow	20.89	17.12	10	65656	452	63422904
Prescribed underdose	20.74	17.12	3	65663	29686	63393670
Growth of eyelashes	20.64	17.12	8	65658	214	63423142
Dyslalia	20.59	17.12	10	65656	467	63422889
Diarrhoea haemorrhagic	20.55	17.12	35	65631	9007	63414349
Unevaluable event	20.48	17.12	14	65652	51372	63371984
Hallucination	20.47	17.12	16	65650	54801	63368555
Eyelid ptosis	20.45	17.12	31	65635	7236	63416120
Full blood count abnormal	20.39	17.12	4	65662	31713	63391643
Respiratory fatigue	20.39	17.12	7	65659	131	63423225
Encapsulating peritoneal sclerosis	20.28	17.12	9	65657	341	63423015
Portal vein dilatation	20.28	17.12	5	65661	26	63423330
Blood phosphorus decreased	20.23	17.12	24	65642	4429	63418927
Jaw operation	20.22	17.12	12	65654	840	63422516
Paraphilia	20.12	17.12	5	65661	27	63423329
Reticulocytosis	20.10	17.12	7	65659	137	63423219
Hyperventilation	19.98	17.12	28	65638	6088	63417268
Encephalopathy	19.91	17.12	86	65580	38534	63384822
Pelvic fluid collection	19.91	17.12	12	65654	864	63422492
Neutropenic sepsis	19.88	17.12	49	65617	16389	63406967
Night sweats	19.86	17.12	13	65653	48801	63374555
Embolism	19.84	17.12	32	65634	7874	63415482
Amnesia	19.79	17.12	17	65649	55568	63367788
Hepatic cytolysis	19.78	17.12	47	65619	15360	63407996
Subclavian vein thrombosis	19.59	17.12	16	65650	1874	63421482
Hypervolaemia	19.55	17.12	3	65663	28410	63394946
Female genital tract fistula	19.53	17.12	31	65635	7528	63415828
Immune-mediated hepatitis	19.48	17.12	14	65652	1357	63421999
Hyperlipasaemia	19.47	17.12	11	65655	702	63422654
Neck pain	19.34	17.12	26	65640	69292	63354064
Loss of consciousness	19.34	17.12	197	65469	117924	63305432
Dry eye	19.27	17.12	9	65657	40752	63382604
Hepatic vein stenosis	19.27	17.12	5	65661	33	63423323
Hypoaesthesia oral	19.22	17.12	42	65624	12991	63410365
Hypothermia	19.16	17.12	43	65623	13538	63409818
Emotional distress	19.14	17.12	5	65661	32544	63390812
Splenic marginal zone lymphoma	18.89	17.12	5	65661	36	63423320
Dysentery	18.89	17.12	12	65654	949	63422407
Rhabdomyolysis	18.86	17.12	11	65655	43940	63379416
Obesity	18.80	17.12	4	65662	29948	63393408
Vasospasm	18.79	17.12	11	65655	751	63422605
Nephrolithiasis	18.75	17.12	10	65656	41974	63381382
Skin reaction	18.74	17.12	45	65621	14804	63408552
Ear pain	18.64	17.12	7	65659	36111	63387245
Altered state of consciousness	18.63	17.12	63	65603	25167	63398189
Femur fracture	18.57	17.12	10	65656	41746	63381610
Hepatic encephalopathy	18.54	17.12	38	65628	11244	63412112
Vaginal cellulitis	18.53	17.12	6	65660	93	63423263
Surgery	18.47	17.12	7	65659	35905	63387451
Toxic encephalopathy	18.42	17.12	28	65638	6551	63416805
Dyspepsia	18.30	17.12	50	65616	102146	63321210
No adverse event	18.29	17.12	10	65656	41395	63381961
Red cell fragmentation syndrome	18.22	17.12	5	65661	42	63423314
Temperature intolerance	18.17	17.12	33	65633	8931	63414425
Diaphragmatic paralysis	18.05	17.12	10	65656	614	63422742
Endometrial dysplasia	17.97	17.12	4	65662	12	63423344
Pigmentation disorder	17.85	17.12	23	65643	4616	63418740
Vascular compression	17.79	17.12	7	65659	195	63423161
Hereditary motor and sensory neuropathy	17.75	17.12	6	65660	107	63423249
Stoma site haemorrhage	17.70	17.12	12	65654	1059	63422297
Blood fibrinogen decreased	17.64	17.12	11	65655	842	63422514
Appendicitis noninfective	17.63	17.12	3	65663	0	63423356
Cognitive disorder	17.63	17.12	19	65647	55796	63367560
Femoral artery embolism	17.62	17.12	5	65661	48	63423308
Acute respiratory distress syndrome	17.59	17.12	59	65607	23475	63399881
Aortitis	17.54	17.12	12	65654	1075	63422281
Aortic thrombosis	17.42	17.12	12	65654	1087	63422269
Full blood count decreased	17.34	17.12	3	65663	26021	63397335
Hyperbilirubinaemia	17.30	17.12	37	65629	11277	63412079

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Neuropathy peripheral	1440.08	15.10	1401	89444	81862	34784224
Disease progression	1133.46	15.10	1398	89447	106679	34759407
Neurotoxicity	784.96	15.10	522	90323	17488	34848598
Diarrhoea	676.89	15.10	2381	88464	387531	34478555
Neutropenia	617.84	15.10	1298	89547	155480	34710606
Dermatitis acneiform	603.12	15.10	303	90542	5886	34860200
Skin toxicity	598.65	15.10	278	90567	4506	34861580
Arteriospasm coronary	576.07	15.10	244	90601	3138	34862948
Palmar-plantar erythrodysaesthesia syndrome	570.83	15.10	418	90427	16377	34849709
Thrombocytopenia	530.77	15.10	1219	89626	155028	34711058
Metastases to liver	386.84	15.10	305	90540	13358	34852728
Paronychia	386.43	15.10	185	90660	3220	34862866
Myelosuppression	381.17	15.10	350	90495	18915	34847171
Polyneuropathy	369.89	15.10	308	90537	14588	34851498
Peripheral sensory neuropathy	366.56	15.10	225	90620	6535	34859551
Erythema	354.59	15.10	740	90105	88040	34778046
Vomiting	351.56	15.10	1421	89424	246200	34619886
Interstitial lung disease	328.58	15.10	600	90245	64682	34801404
Venoocclusive liver disease	292.82	15.10	208	90637	7758	34858328
Nausea	290.77	15.10	1686	89159	338222	34527864
Paraesthesia	287.18	15.10	561	90284	63611	34802475
Mucosal inflammation	272.13	15.10	413	90432	38209	34827877
Portal hypertension	272.11	15.10	155	90690	3907	34862179
Product dose omission issue	270.72	15.10	9	90836	119702	34746384
Chills	263.13	15.10	622	90223	80421	34785665
Hypersensitivity	256.76	15.10	520	90325	60515	34805571
Haematotoxicity	256.09	15.10	194	90651	8000	34858086
Gastrointestinal toxicity	249.93	15.10	128	90717	2591	34863495
Completed suicide	239.14	15.10	3	90842	98165	34767921
Gastrointestinal perforation	228.57	15.10	136	90709	3727	34862359
Bone marrow failure	227.91	15.10	328	90517	28925	34837161
Arthralgia	225.90	15.10	80	90765	169961	34696125
Enteritis	218.13	15.10	176	90669	7966	34858120
Stomatitis	212.81	15.10	390	90455	42124	34823962
Metastases to lung	197.41	15.10	176	90669	9144	34856942
Drug interaction	181.42	15.10	192	90653	225754	34640332
Drug ineffective	178.87	15.10	601	90244	456150	34409936
Fall	173.64	15.10	163	90682	202722	34663364
Cardiotoxicity	172.69	15.10	132	90713	5516	34860570
Laryngospasm	167.61	15.10	81	90764	1440	34864646
Headache	166.11	15.10	166	90679	200469	34665617
Flushing	165.50	15.10	300	90545	32120	34833966
Overdose	157.97	15.10	24	90821	91035	34775051
Focal nodular hyperplasia	156.10	15.10	43	90802	120	34865966
Bronchospasm	154.55	15.10	164	90681	10567	34855519
Decreased appetite	154.47	15.10	845	90000	165547	34700539
Malignant neoplasm progression	152.17	15.10	539	90306	87507	34778579
Therapy partial responder	151.13	15.10	154	90691	9462	34856624
Pneumonia	145.95	15.10	471	90374	362156	34503930
Carcinoembryonic antigen increased	144.24	15.10	58	90787	647	34865439
Hypomagnesaemia	143.11	15.10	226	90619	21625	34844461
Hyperammonaemic encephalopathy	140.58	15.10	83	90762	2241	34863845
Neoplasm progression	139.00	15.10	231	90614	23069	34843017
Abdominal pain	133.53	15.10	803	90042	162815	34703271
Dysaesthesia pharynx	127.46	15.10	30	90815	31	34866055
Hyperammonaemia	124.56	15.10	115	90730	6252	34859834
Tumour perforation	118.54	15.10	41	90804	288	34865798
Proteinuria	118.21	15.10	190	90655	18452	34847634
Enterocolitis	117.95	15.10	124	90721	7902	34858184
Cardiac failure congestive	117.82	15.10	35	90810	83235	34782851
Metastases to peritoneum	117.19	15.10	68	90777	1776	34864310
Leukopenia	116.55	15.10	394	90451	62462	34803624
Skin reaction	115.21	15.10	101	90744	5129	34860957
Anastomotic leak	112.36	15.10	47	90798	584	34865502
Infusion related reaction	110.45	15.10	346	90499	52711	34813375
Pyrexia	110.33	15.10	1335	89510	331678	34534408
Feeling hot	108.84	15.10	187	90658	19185	34846901
Insomnia	108.48	15.10	68	90777	103839	34762247
Hospitalisation	108.40	15.10	11	90834	56891	34809195
Depression	107.80	15.10	59	90786	97039	34769047
Neutrophil count decreased	107.06	15.10	334	90511	50770	34815316
Oxygen saturation decreased	104.79	15.10	343	90502	53475	34812611
Dehydration	103.48	15.10	634	90211	129335	34736751
Joint swelling	101.10	15.10	17	90828	59873	34806213
Intestinal obstruction	100.11	15.10	198	90647	22624	34843462
Toxic leukoencephalopathy	99.25	15.10	38	90807	368	34865718
Pneumatosis intestinalis	99.18	15.10	82	90763	3841	34862245
Intravascular haemolysis	97.63	15.10	39	90806	427	34865659
Stomal varices	97.30	15.10	26	90819	62	34866024
Anxiety	97.17	15.10	70	90775	99358	34766728
Weight increased	96.95	15.10	61	90784	92972	34773114
Peripheral swelling	96.51	15.10	39	90806	76502	34789584
Myalgia	96.47	15.10	49	90796	84061	34782025
Ascites	96.28	15.10	303	90542	46268	34819818
Varices oesophageal	93.91	15.10	78	90767	3677	34862409
Anaphylactic shock	93.67	15.10	157	90688	15784	34850302
Inappropriate schedule of product administration	90.30	15.10	25	90820	62271	34803815
Tumour necrosis	88.55	15.10	50	90795	1238	34864848
Influenza	86.30	15.10	13	90832	49653	34816433
Rhabdomyolysis	85.50	15.10	35	90810	68128	34797958
Aggression	84.39	15.10	4	90841	38960	34827126
Somnolence	83.99	15.10	99	90746	111017	34755069
Laryngeal discomfort	82.68	15.10	28	90817	183	34865903
Rheumatoid arthritis	82.57	15.10	4	90841	38234	34827852
Anastomotic complication	81.75	15.10	33	90812	372	34865714
Type I hypersensitivity	81.45	15.10	48	90797	1291	34864795
Rash pustular	80.27	15.10	84	90761	5324	34860762
Pain in extremity	80.25	15.10	128	90717	126385	34739701
Injection site pain	78.45	15.10	6	90839	38999	34827087
Hallucination	77.81	15.10	19	90826	51479	34814607
Febrile neutropenia	77.30	15.10	614	90231	136235	34729851
Ileus	75.83	15.10	146	90699	16353	34849733
Non-cirrhotic portal hypertension	75.33	15.10	28	90817	248	34865838
Dihydropyrimidine dehydrogenase deficiency	74.63	15.10	21	90824	65	34866021
Colorectal cancer metastatic	74.34	15.10	37	90808	703	34865383
Incorrect dose administered	74.21	15.10	9	90836	40506	34825580
Diffuse large B-cell lymphoma recurrent	72.43	15.10	63	90782	3165	34862921
Suicidal ideation	71.50	15.10	10	90835	40378	34825708
Metastases to lymph nodes	71.18	15.10	74	90771	4654	34861432
Extravasation	70.94	15.10	50	90795	1840	34864246
Death	70.29	15.10	679	90166	397370	34468716
Peritonitis	69.39	15.10	140	90705	16225	34849861
Contusion	69.33	15.10	7	90838	36357	34829729
Hyperhidrosis	69.10	15.10	383	90462	75309	34790777
Myocardial infarction	68.18	15.10	132	90713	120953	34745133
Portal shunt	68.15	15.10	17	90828	27	34866059
Asthma	67.94	15.10	14	90831	42642	34823444
Blood glucose increased	67.78	15.10	45	90800	66673	34799413
Rectal perforation	66.66	15.10	30	90815	450	34865636
Foetal exposure during pregnancy	66.13	15.10	10	90835	38091	34827995
Splenomegaly	66.10	15.10	131	90714	14986	34851100
Large intestine perforation	65.68	15.10	95	90750	8408	34857678
Confusional state	65.14	15.10	177	90668	143983	34722103
Vascular pain	64.42	15.10	22	90823	148	34865938
Hypertransaminasaemia	64.13	15.10	76	90769	5530	34860556
Disseminated intravascular coagulation	63.79	15.10	161	90684	21655	34844431
Toxicity to various agents	63.64	15.10	286	90559	200076	34666010
Memory impairment	63.49	15.10	17	90828	43301	34822785
Hepatic atrophy	62.83	15.10	22	90823	161	34865925
Electrocardiogram ST segment elevation	61.56	15.10	72	90773	5166	34860920
Nasopharyngitis	61.15	15.10	55	90790	69913	34796173
Agitation	60.65	15.10	37	90808	57362	34808724
Arthritis	59.84	15.10	6	90839	31340	34834746
Product use issue	59.81	15.10	46	90799	63170	34802916
Coronary artery disease	58.65	15.10	26	90819	48279	34817807
Tumour lysis syndrome	58.60	15.10	134	90711	16925	34849161
Therapeutic product effect decreased	58.32	15.10	10	90835	34733	34831353
Colon cancer metastatic	58.20	15.10	42	90803	1605	34864481
Palmar erythema	58.20	15.10	24	90821	287	34865799
Dysphonia	57.67	15.10	162	90683	23221	34842865
Feeling abnormal	57.33	15.10	48	90797	63187	34802899
Temperature intolerance	55.95	15.10	56	90789	3366	34862720
Hyperthermia	55.37	15.10	99	90746	10478	34855608
Pain	54.81	15.10	310	90535	204365	34661721
Electrocardiogram QT prolonged	54.73	15.10	19	90826	40933	34825153
Intestinal perforation	54.25	15.10	90	90755	8970	34857116
Chronic obstructive pulmonary disease	53.86	15.10	30	90815	48888	34817198
Necrotising fasciitis	53.79	15.10	57	90788	3665	34862421
Dysaesthesia	53.77	15.10	46	90799	2259	34863827
Asthenia	53.65	15.10	915	89930	244336	34621750
Paraesthesia oral	53.22	15.10	60	90785	4137	34861949
Cholangitis	52.95	15.10	87	90758	8602	34857484
Cholinergic syndrome	52.11	15.10	27	90818	560	34865526
Irritability	52.00	15.10	3	90842	24687	34841399
Nodular regenerative hyperplasia	51.75	15.10	32	90813	941	34865145
Musculoskeletal stiffness	50.86	15.10	29	90816	46651	34819435
Drug dependence	50.82	15.10	3	90842	24214	34841872
Sinusitis	50.71	15.10	22	90823	41380	34824706
Subileus	49.78	15.10	51	90794	3152	34862934
Hiccups	49.78	15.10	92	90753	9990	34856096
Cellulitis	49.49	15.10	39	90806	52912	34813174
Unevaluable event	49.27	15.10	12	90833	32578	34833508
Stoma site haemorrhage	49.20	15.10	30	90815	860	34865226
Administration site extravasation	48.52	15.10	26	90819	579	34865507
General physical health deterioration	48.39	15.10	528	90317	127741	34738345
Treatment noncompliance	47.36	15.10	8	90837	28092	34837994
Dizziness	47.31	15.10	353	90492	218168	34647918
Recall phenomenon	47.09	15.10	25	90820	546	34865540
Malignant ascites	46.69	15.10	23	90822	427	34865659
Neutropenic sepsis	46.03	15.10	107	90738	13660	34852426
Drug level increased	45.58	15.10	3	90842	22093	34843993
Perforation	45.36	15.10	19	90826	237	34865849
Blood pressure fluctuation	45.28	15.10	6	90839	25243	34840843
Mucosal toxicity	45	15.10	19	90826	242	34865844
Transdifferentiation of neoplasm	44.97	15.10	14	90831	67	34866019
Cyanosis	44.66	15.10	101	90744	12663	34853423
Abdominal discomfort	44.44	15.10	54	90791	59781	34806305
Pulmonary embolism	44.39	15.10	391	90454	89355	34776731
Folliculitis	44.33	15.10	57	90788	4509	34861577
Condition aggravated	44.24	15.10	305	90540	191891	34674195
Gastrointestinal anastomotic leak	44.01	15.10	22	90823	422	34865664
Enterovesical fistula	43.97	15.10	27	90818	784	34865302
Off label use	43.71	15.10	1411	89434	418113	34447973
Wound dehiscence	43.12	15.10	48	90797	3263	34862823
Septic shock	43.09	15.10	327	90518	71507	34794579
Prinzmetal angina	43.06	15.10	29	90816	990	34865096
Anastomotic fistula	42.92	15.10	14	90831	80	34866006
Wrong technique in product usage process	42.70	15.10	20	90825	35966	34830120
Splenorenal shunt	42.65	15.10	10	90835	10	34866076
Abnormal behaviour	42.32	15.10	7	90838	24962	34841124
Intestinal ischaemia	42.15	15.10	74	90771	7720	34858366
Hypertensive crisis	42.13	15.10	79	90766	8672	34857414
Blood alkaline phosphatase abnormal	42.13	15.10	22	90823	464	34865622
Immune thrombocytopenia	42.06	15.10	81	90764	9071	34857015
Hypokalaemia	41.92	15.10	277	90568	57937	34808149
Chronic kidney disease	41.57	15.10	28	90817	41182	34824904
Psychotic disorder	41.12	15.10	7	90838	24445	34841641
Portal vein thrombosis	41.11	15.10	50	90795	3738	34862348
Evans syndrome	41.11	15.10	18	90827	252	34865834
Anaphylactic reaction	40.54	15.10	179	90666	32122	34833964
Fluid retention	40.45	15.10	10	90835	26877	34839209
Noninfective epididymitis	39.64	15.10	8	90837	0	34866086
Oxygen saturation normal	39.64	15.10	8	90837	0	34866086
Premature baby	39.53	15.10	3	90842	19630	34846456
Pulmonary toxicity	39.43	15.10	63	90782	6084	34860002
International normalised ratio increased	39.24	15.10	39	90806	47288	34818798
Contraindicated product administered	38.78	15.10	5	90840	21476	34844610
Large intestinal obstruction	38.62	15.10	32	90813	1503	34864583
Throat tightness	38.45	15.10	74	90771	8284	34857802
Blood creatine phosphokinase increased	38.31	15.10	36	90809	44821	34821265
Drug reaction with eosinophilia and systemic symptoms	38.17	15.10	19	90826	32993	34833093
Gastric perforation	37.14	15.10	39	90806	2481	34863605
Hypercreatinaemia	37.01	15.10	15	90830	171	34865915
Small intestinal obstruction	36.66	15.10	103	90742	14763	34851323
Influenza like illness	36.62	15.10	13	90832	27621	34838465
Blood cholesterol increased	36.56	15.10	5	90840	20538	34845548
Acute coronary syndrome	36.55	15.10	97	90748	13448	34852638
Nicotinic acid deficiency	36.24	15.10	13	90832	103	34865983
Diabetes mellitus	36.20	15.10	41	90804	46832	34819254
Prostate cancer	36.05	15.10	30	90815	39619	34826467
Blood pressure immeasurable	36.00	15.10	25	90820	898	34865188
Blood pressure systolic increased	35.59	15.10	8	90837	22944	34843142
Type II hypersensitivity	35.52	15.10	10	90835	31	34866055
Bronchitis	35.46	15.10	34	90811	41929	34824157
Leukoencephalopathy	35.37	15.10	49	90796	4166	34861920
Cardiac disorder	35.22	15.10	36	90809	43090	34822996
Herpes zoster	35.20	15.10	23	90822	34376	34831710
Pseudocirrhosis	35.10	15.10	9	90836	17	34866069
Drug withdrawal syndrome	34.89	15.10	5	90840	19829	34846257
Portal venous gas	34.84	15.10	18	90827	371	34865715
Oesophagitis	34.80	15.10	94	90751	13167	34852919
Hepatic infarction	34.65	15.10	15	90830	204	34865882
Hypervolaemia	34.60	15.10	5	90840	19704	34846382
Hyperkalaemia	34.56	15.10	81	90764	69308	34796778
Localised infection	34.54	15.10	3	90842	17584	34848502
Medication error	33.92	15.10	12	90833	25553	34840533
Swelling	33.89	15.10	36	90809	42330	34823756
Acute abdomen	33.83	15.10	33	90812	1922	34864164
Cytokine release syndrome	33.57	15.10	133	90712	22744	34843342
Stridor	33.46	15.10	37	90808	2497	34863589
Cytomegalovirus infection	33.44	15.10	13	90832	26122	34839964
Tumour marker increased	33.35	15.10	21	90824	638	34865448
Hyperbilirubinaemia	33.34	15.10	108	90737	16735	34849351
Sedation	33.23	15.10	7	90838	20999	34845087
Papilloedema	33.07	15.10	38	90807	2675	34863411
Amaurosis fugax	33.03	15.10	20	90825	566	34865520
Liver function test abnormal	32.86	15.10	20	90825	31054	34835032
Small intestinal perforation	32.72	15.10	34	90811	2137	34863949
Upper respiratory tract infection	32.62	15.10	23	90822	33036	34833050
Type III immune complex mediated reaction	32.58	15.10	16	90829	295	34865791
Seizure	32.44	15.10	151	90694	104706	34761380
Mobility decreased	32.41	15.10	19	90826	30109	34835977
Oesophageal haemorrhage	32.18	15.10	27	90818	1291	34864795
Performance status decreased	31.63	15.10	46	90799	4091	34861995
Metastasis	31.57	15.10	46	90799	4098	34861988
Productive cough	31.53	15.10	31	90814	37782	34828304
Carbohydrate antigen 19-9 increased	31.35	15.10	14	90831	206	34865880
Cerebrovascular accident	31.31	15.10	114	90731	84697	34781389
Accidental overdose	31.27	15.10	7	90838	20133	34845953
Pelvic abscess	31.04	15.10	23	90822	916	34865170
Head injury	30.98	15.10	5	90840	18155	34847931
Haemoglobin abnormal	30.92	15.10	44	90801	3836	34862250
Haematoma	30.73	15.10	14	90831	25591	34840495
Encapsulating peritoneal sclerosis	30.39	15.10	19	90826	570	34865516
Adenocarcinoma	30.35	15.10	31	90814	1909	34864177
Ocular toxicity	30.29	15.10	14	90831	224	34865862
Nasal congestion	30.29	15.10	11	90834	23046	34843040
Sleep disorder	30.03	15.10	23	90822	31665	34834421
Dyspnoea	29.81	15.10	1229	89616	375553	34490533
ECG signs of myocardial ischaemia	29.56	15.10	13	90832	184	34865902
Liver abscess	29.33	15.10	43	90802	3852	34862234
Hepatectomy	29.32	15.10	10	90835	67	34866019
Hypovolaemic shock	29.30	15.10	60	90785	7025	34859061
Sciatic nerve palsy	29.27	15.10	9	90836	41	34866045
Haemolytic anaemia	29.25	15.10	76	90769	10403	34855683
Perforation bile duct	29.13	15.10	8	90837	22	34866064
Circulatory collapse	29.03	15.10	120	90725	20918	34845168
Eosinophilia	28.98	15.10	16	90829	26206	34839880
Lymphangiosis carcinomatosa	28.97	15.10	22	90823	910	34865176
Muscular weakness	28.92	15.10	95	90750	72802	34793284
Trismus	28.83	15.10	34	90811	2461	34863625
Nephrolithiasis	28.77	15.10	22	90823	30311	34835775
Gene mutation	28.65	15.10	26	90819	1382	34864704
Rectal cancer metastatic	28.59	15.10	13	90832	200	34865886
Erectile dysfunction	28.58	15.10	9	90836	20628	34845458
Oesophageal varices haemorrhage	28.56	15.10	38	90807	3108	34862978
Failure to anastomose	28.47	15.10	13	90832	202	34865884
Device related infection	28.41	15.10	104	90741	17133	34848953
Emotional distress	28.36	15.10	3	90842	15023	34851063
Laryngeal oedema	28.27	15.10	40	90805	3468	34862618
Acute respiratory distress syndrome	28.23	15.10	138	90707	25831	34840255
Adverse drug reaction	28.19	15.10	21	90824	29321	34836765
Liver injury	28.19	15.10	94	90751	14784	34851302
Peripheral sensorimotor neuropathy	27.93	15.10	27	90818	1555	34864531
Hypoalbuminaemia	27.75	15.10	82	90763	12092	34853994
Cachexia	27.56	15.10	59	90786	7127	34858959
Delirium	27.39	15.10	45	90800	43946	34822140
Anaphylactoid reaction	27.39	15.10	32	90813	2293	34863793
Rectosigmoid cancer	27.34	15.10	12	90833	169	34865917
Biliary fistula	27.23	15.10	9	90836	54	34866032
Right ventricular ejection fraction decreased	27.23	15.10	9	90836	54	34866032
Road traffic accident	27.22	15.10	6	90839	17444	34848642
Haemoglobinuria	27.19	15.10	18	90827	597	34865489
Anal sphincter atony	27.06	15.10	10	90835	87	34865999
Brain teratoma	27.03	15.10	7	90838	14	34866072
Pulmonary oedema	26.56	15.10	52	90793	47477	34818609
Basal cell carcinoma	26.47	15.10	9	90836	19649	34846437
Subdural haematoma	26.39	15.10	10	90835	20411	34845675
Osteomyelitis	26.31	15.10	5	90840	16131	34849955
Hepatocellular injury	26.30	15.10	121	90724	22090	34843996
Hypoglycaemia	26.24	15.10	65	90780	54575	34811511
Pulmonary fibrosis	26.23	15.10	106	90739	18290	34847796
Oedema peripheral	26.14	15.10	193	90652	119619	34746467
Vocal cord paralysis	26.12	15.10	21	90824	945	34865141
Renal disorder	26.12	15.10	17	90828	25463	34840623
Wheezing	26.11	15.10	42	90803	41360	34824726
Full blood count abnormal	26.10	15.10	8	90837	18660	34847426
Necrotising oesophagitis	26.08	15.10	17	90828	549	34865537
Haemorrhage intracranial	25.87	15.10	5	90840	15941	34850145
Ileal perforation	25.86	15.10	19	90826	747	34865339
Labelled drug-drug interaction medication error	25.74	15.10	4	90841	14935	34851151
Aortic thrombosis	25.59	15.10	19	90826	759	34865327
Gait disturbance	25.51	15.10	124	90721	85016	34781070
Blood pressure increased	25.43	15.10	130	90715	87972	34778114
Gastrointestinal obstruction	25.32	15.10	20	90825	877	34865209
Hyperaemia	25.29	15.10	23	90822	1226	34864860
Blood creatinine increased	25.29	15.10	144	90701	94832	34771254
Embolism	25.24	15.10	60	90785	7769	34858317
Pruritus	24.82	15.10	512	90333	141469	34724617
Hepatic failure	24.66	15.10	164	90681	34367	34831719
Loss of personal independence in daily activities	24.57	15.10	30	90815	33149	34832937
Cold sweat	24.43	15.10	69	90776	9918	34856168
Hyperpyrexia	24.28	15.10	33	90812	2755	34863331
Heart rate decreased	24.26	15.10	28	90817	31717	34834369
Periportal sinus dilatation	24.03	15.10	11	90834	172	34865914
Gout	23.94	15.10	10	90835	19243	34846843
Oesophagobronchial fistula	23.86	15.10	11	90834	175	34865911
Biliary tract infection	23.83	15.10	17	90828	638	34865448
Injection site erythema	23.75	15.10	6	90839	15893	34850193
Cataract	23.57	15.10	20	90825	26166	34839920
Koebner phenomenon	23.53	15.10	8	90837	53	34866033
Laboratory test abnormal	23.18	15.10	12	90833	20379	34845707
Cardiac ventricular disorder	23.16	15.10	12	90833	249	34865837
Diffuse large B-cell lymphoma refractory	23.10	15.10	22	90823	1244	34864842
Lower respiratory tract infection	23.01	15.10	29	90816	31608	34834478
Wound infection	22.55	15.10	54	90791	7025	34859061
Thrombotic thrombocytopenic purpura	22.25	15.10	35	90810	3335	34862751
Withdrawal syndrome	22.24	15.10	3	90842	12452	34853634
Respiratory arrest	22.23	15.10	24	90821	28019	34838067
Aortitis	22.21	15.10	14	90831	426	34865660
Tachycardia	22.12	15.10	326	90519	84446	34781640
Blood lactate dehydrogenase increased	22.07	15.10	118	90727	22872	34843214
Throat irritation	21.97	15.10	69	90776	10516	34855570
Fingerprint loss	21.92	15.10	7	90838	37	34866049
Adenocarcinoma metastatic	21.92	15.10	7	90838	37	34866049
Haematemesis	21.87	15.10	135	90710	27576	34838510
Pulmonary artery thrombosis	21.81	15.10	17	90828	731	34865355
Astringent therapy	21.71	15.10	6	90839	17	34866069
Poisoning	21.70	15.10	3	90842	12223	34853863
Angioedema	21.66	15.10	40	90805	37334	34828752
Band sensation	21.65	15.10	9	90836	110	34865976
Pachymeningitis	21.57	15.10	9	90836	111	34865975
Full blood count decreased	21.54	15.10	10	90835	18078	34848008
Pelvic fluid collection	21.47	15.10	10	90835	163	34865923
Nephrotic syndrome	21.45	15.10	54	90791	7249	34858837
Balance disorder	21.42	15.10	46	90799	40608	34825478
Pulmonary hypertension	21.39	15.10	14	90831	20910	34845176
Onycholysis	21.34	15.10	17	90828	755	34865331
Hyperfibrinolysis	21.22	15.10	6	90839	19	34866067
Obstruction gastric	21.19	15.10	19	90826	994	34865092
Perihepatic abscess	21.15	15.10	9	90836	117	34865969
Cholestasis	21.09	15.10	131	90714	26817	34839269
Hepatic lesion	21.06	15.10	36	90809	3676	34862410
Fistula of small intestine	21.05	15.10	14	90831	468	34865618
Obstructive airways disorder	21.02	15.10	7	90838	15487	34850599
Metastases to muscle	20.98	15.10	11	90834	234	34865852
Muscle contractions involuntary	20.96	15.10	25	90820	1831	34864255
Monocytopenia	20.94	15.10	8	90837	77	34866009
Cerebral vasoconstriction	20.73	15.10	11	90834	240	34865846
Hypotension	20.55	15.10	736	90109	220913	34645173
Interventricular septum rupture	20.55	15.10	6	90839	22	34866064
Metastases to retroperitoneum	20.53	15.10	11	90834	245	34865841
Gastrointestinal mucosal necrosis	20.48	15.10	10	90835	182	34865904
Xerosis	20.43	15.10	15	90830	589	34865497
Intentional product use issue	20.40	15.10	83	90762	59733	34806353
Acral peeling skin syndrome	20.26	15.10	7	90838	49	34866037
Vascular access complication	20.09	15.10	12	90833	331	34865755
Product prescribing error	20.05	15.10	18	90827	22909	34843177
Skin fissures	19.96	15.10	43	90802	5216	34860870
Mucocutaneous rash	19.94	15.10	6	90839	25	34866061
Blood triglycerides increased	19.92	15.10	6	90839	14153	34851933
Gastric dilatation	19.92	15.10	16	90829	719	34865367
Hypersomnia	19.90	15.10	4	90841	12403	34853683
Induration	19.83	15.10	18	90827	957	34865129
Peripheral nerve injury	19.76	15.10	10	90835	197	34865889
Metastases to bone marrow	19.65	15.10	14	90831	524	34865562
Portal vein dilatation	19.65	15.10	5	90840	9	34866077
Hot flush	19.63	15.10	96	90749	17970	34848116
Jaundice	19.59	15.10	146	90699	31736	34834350
Hypophagia	19.57	15.10	118	90727	23904	34842182
Catheter site extravasation	19.52	15.10	8	90837	94	34865992
Product administration error	19.52	15.10	9	90836	16335	34849751
Intestinal dilatation	19.47	15.10	20	90825	1240	34864846
Alopecia	19.44	15.10	119	90726	24236	34841850
Choking sensation	19.43	15.10	19	90826	1110	34864976
COVID-19	19.36	15.10	120	90725	77430	34788656
Respiratory depression	19.31	15.10	9	90836	16236	34849850
Ischiorectal hernia	19.31	15.10	5	90840	10	34866076
Hand-foot-genital syndrome	19.31	15.10	5	90840	10	34866076
Rhinorrhoea	19.23	15.10	23	90822	25645	34840441
Sarcoidosis	19.08	15.10	30	90815	2858	34863228
Diaphragmatic operation	19.06	15.10	6	90839	30	34866056
Therapy interrupted	18.92	15.10	6	90839	13691	34852395
Chronic myeloid leukaemia	18.88	15.10	26	90819	2198	34863888
Peritoneal haematoma	18.83	15.10	7	90838	62	34866024
Peritoneal lesion	18.80	15.10	8	90837	104	34865982
Adverse event	18.80	15.10	13	90832	18864	34847222
Oropharyngeal spasm	18.72	15.10	9	90836	158	34865928
Anger	18.71	15.10	4	90841	11880	34854206
Cytopenia	18.69	15.10	74	90771	12649	34853437
Neoplasm recurrence	18.65	15.10	26	90819	2223	34863863
Loss of consciousness	18.56	15.10	310	90535	82357	34783729
Ventricular dysfunction	18.48	15.10	35	90810	3870	34862216
Heart rate irregular	18.42	15.10	9	90836	15798	34850288
Appendicitis noninfective	18.41	15.10	5	90840	13	34866073
Limb injury	18.27	15.10	4	90841	11685	34854401
Disease susceptibility	18.26	15.10	7	90838	68	34866018
Transient aphasia	18.26	15.10	12	90833	393	34865693
Skin laceration	18.15	15.10	5	90840	12504	34853582
Perineal disorder	18.08	15.10	7	90838	70	34866016
Colon cancer recurrent	18.08	15.10	8	90837	115	34865971
Stomal hernia	17.99	15.10	10	90835	240	34865846
Pneumatosis	17.92	15.10	13	90832	501	34865585
Chemical peritonitis	17.83	15.10	8	90837	119	34865967
Viral infection	17.73	15.10	12	90833	17611	34848475
Peripheral ischaemia	17.71	15.10	43	90802	5644	34860442
Pulmonary infarction	17.63	15.10	20	90825	1388	34864698
Abdominal pain lower	17.61	15.10	64	90781	10507	34855579
Neurosarcoidosis	17.53	15.10	9	90836	183	34865903
Platelet count decreased	17.52	15.10	421	90424	119296	34746790
Pneumonitis chemical	17.44	15.10	9	90836	185	34865901
Perineal ulceration	17.41	15.10	5	90840	17	34866069
Underdose	17.39	15.10	7	90838	13773	34852313
Blindness transient	17.38	15.10	25	90820	2201	34863885
Feeling cold	17.37	15.10	64	90781	10575	34855511
Shock	17.36	15.10	115	90730	24064	34842022
Sinus bradycardia	17.34	15.10	6	90839	12957	34853129
Mental impairment	17.26	15.10	3	90842	10319	34855767
Device related thrombosis	17.25	15.10	18	90827	1137	34864949
Conjunctivitis	17.23	15.10	60	90785	9645	34856441
Hypoxia	17.23	15.10	79	90766	55016	34811070
Acute motor-sensory axonal neuropathy	17.20	15.10	8	90837	130	34865956
Hypersplenism	17.16	15.10	12	90833	436	34865650
Intrahepatic portal hepatic venous fistula	17.06	15.10	4	90841	4	34866082
Nephritis allergic	17.04	15.10	12	90833	441	34865645
Abdominal sepsis	17.04	15.10	17	90828	1018	34865068
Malaise	16.95	15.10	616	90229	185209	34680877
Gastrointestinal stoma complication	16.93	15.10	19	90826	1303	34864783
Microangiopathic haemolytic anaemia	16.93	15.10	16	90829	896	34865190
Blood potassium increased	16.91	15.10	11	90834	16484	34849602
Dyskinesia	16.88	15.10	20	90825	22393	34843693
VIth nerve disorder	16.78	15.10	5	90840	20	34866066
Metastases to spleen	16.66	15.10	12	90833	457	34865629
Peritoneal disorder	16.64	15.10	10	90835	279	34865807
Oral dysaesthesia	16.59	15.10	7	90838	89	34865997
Thyroglobulin increased	16.59	15.10	5	90840	21	34866065
Vascular injury	16.58	15.10	10	90835	281	34865805
Gastrointestinal necrosis	16.56	15.10	31	90814	3398	34862688
Venoocclusive disease	16.52	15.10	28	90817	2839	34863247
Peripheral motor neuropathy	16.49	15.10	22	90823	1804	34864282
Bronchostenosis	16.48	15.10	10	90835	284	34865802
Tooth disorder	16.46	15.10	4	90841	10878	34855208
Bacterial colitis	16.36	15.10	6	90839	51	34866035
Blood bilirubin decreased	16.32	15.10	11	90834	376	34865710
Retroperitoneal mass	16.31	15.10	7	90838	93	34865993
Blood glucose decreased	16.26	15.10	7	90838	13230	34852856
Allodynia	16.23	15.10	15	90830	816	34865270
Skin disorder	16.16	15.10	74	90771	13481	34852605
Adenovirus reactivation	16.15	15.10	9	90836	217	34865869
Vascular access site occlusion	16.06	15.10	6	90839	54	34866032
Device issue	16.00	15.10	3	90842	9774	34856312
Electromyogram abnormal	15.96	15.10	6	90839	55	34866031
Hypoaesthesia	15.91	15.10	236	90609	61208	34804878
Squamous cell carcinoma	15.90	15.10	5	90840	11470	34854616
Oesophageal carcinoma recurrent	15.88	15.10	5	90840	25	34866061
Eczema impetiginous	15.88	15.10	5	90840	25	34866061
Radiation interaction	15.88	15.10	5	90840	25	34866061
Stevens-Johnson syndrome	15.86	15.10	15	90830	18624	34847462
Coma	15.81	15.10	63	90782	45615	34820471
Rectal obstruction	15.79	15.10	4	90841	7	34866079
Metastases to pelvis	15.79	15.10	10	90835	307	34865779
Mental disorder	15.79	15.10	10	90835	15199	34850887
Urinary tract infection	15.77	15.10	141	90704	83940	34782146
Nail disorder	15.72	15.10	23	90822	2056	34864030
Trichomegaly	15.72	15.10	5	90840	26	34866060
Abdominal mass	15.63	15.10	19	90826	1420	34864666
Hepatic cancer recurrent	15.62	15.10	10	90835	313	34865773
Ichthyosis	15.61	15.10	7	90838	104	34865982
Toxic epidermal necrolysis	15.58	15.10	20	90825	21626	34844460
Eczema	15.50	15.10	15	90830	18421	34847665
Platelet count increased	15.43	15.10	3	90842	9523	34856563
Volvulus of small bowel	15.33	15.10	6	90839	62	34866024
Pneumoperitoneum	15.31	15.10	21	90824	1769	34864317
Duodenal stenosis	15.27	15.10	9	90836	242	34865844
Hypoacusis	15.23	15.10	12	90833	16289	34849797
Pancreatitis	15.20	15.10	51	90794	38840	34827246
Faeces discoloured	15.15	15.10	10	90835	14868	34851218
Surgery	15.12	15.10	9	90836	14148	34851938

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Neuropathy peripheral	2916.44	15.18	2226	138058	139079	79465025
Disease progression	2079.77	15.18	2058	138226	182304	79421800
Neutropenia	1620.80	15.18	2248	138036	285462	79318642
Neurotoxicity	1535.80	15.18	862	139422	31656	79572448
Thrombocytopenia	1281.53	15.18	1928	138356	263331	79340773
Diarrhoea	1083.99	15.18	3696	136588	876793	78727311
Palmar-plantar erythrodysaesthesia syndrome	969.82	15.18	647	139637	32487	79571617
Laryngospasm	966.77	15.18	335	139949	3662	79600442
Dermatitis acneiform	953.33	15.18	427	139857	9566	79594538
Arteriospasm coronary	872.04	15.18	357	139927	6359	79597745
Skin toxicity	840.44	15.18	370	139914	7944	79596160
Myelosuppression	753.39	15.18	600	139684	39696	79564408
Paraesthesia	713.53	15.18	1183	139101	175140	79428964
Polyneuropathy	659.84	15.18	452	139832	23699	79580405
Peripheral sensory neuropathy	651.94	15.18	359	139925	12674	79591430
Mucosal inflammation	635.51	15.18	723	139561	74857	79529247
Arthralgia	582.70	15.18	145	140139	571658	79032446
Vomiting	582.34	15.18	2512	137772	663316	78940788
Metastases to liver	542.92	15.18	428	139856	27886	79576218
Bone marrow failure	518.74	15.18	540	139744	50567	79553537
Venoocclusive liver disease	504.33	15.18	293	139991	11478	79592626
Paronychia	503.87	15.18	255	140029	7553	79596551
Erythema	484.52	15.18	1154	139130	222136	79381968
Nausea	428.58	15.18	3010	137274	954186	78649918
Interstitial lung disease	414.75	15.18	725	139559	111875	79492229
Bronchospasm	411.65	15.18	345	139939	24514	79579590
Headache	410.50	15.18	330	139954	653442	78950662
Chills	404.99	15.18	880	139404	159354	79444750
Portal hypertension	403.55	15.18	213	140071	6895	79597209
Haematotoxicity	401.67	15.18	281	140003	15238	79588866
Joint swelling	390.91	15.18	31	140253	288615	79315489
Gastrointestinal toxicity	385.38	15.18	216	140068	7893	79596211
Product dose omission issue	373.97	15.18	14	140270	247523	79356581
Neoplasm progression	365.88	15.18	453	139831	51229	79552875
Enteritis	363.38	15.18	258	140026	14325	79589779
Rheumatoid arthritis	340.73	15.18	5	140279	208465	79395639
Dysaesthesia pharynx	326.73	15.18	76	140208	141	79603963
Gastrointestinal perforation	326.16	15.18	176	140108	5961	79598143
Pain	295.92	15.18	490	139794	703312	78900792
Therapy partial responder	295.40	15.18	245	140039	17152	79586952
Fall	294.78	15.18	255	140029	487374	79116730
Cardiotoxicity	294.53	15.18	212	140072	12027	79592077
Stridor	294.32	15.18	158	140126	5295	79598809
Malignant neoplasm progression	292.63	15.18	701	139583	135289	79468815
Type I hypersensitivity	290.70	15.18	146	140138	4252	79599852
Arthropathy	290.49	15.18	4	140280	177107	79426997
Metastases to lung	290.27	15.18	247	140037	17916	79586188
Non-cirrhotic portal hypertension	279.28	15.18	79	140205	408	79603696
Drug ineffective	279.01	15.18	974	139310	1079939	78524165
Febrile neutropenia	277.09	15.18	965	139319	230034	79374070
Throat tightness	274.39	15.18	290	139994	27617	79576487
Leukopenia	271.84	15.18	620	139664	115893	79488211
Neutrophil count decreased	267.46	15.18	542	139742	93417	79510687
Drug abuse	265.40	15.18	4	140280	162687	79441417
Peripheral swelling	263.40	15.18	74	140210	269543	79334561
Weight increased	253.26	15.18	86	140198	277300	79326804
Sinusitis	251.14	15.18	26	140258	195475	79408629
Flushing	243.92	15.18	503	139781	87765	79516339
Nasopharyngitis	243.72	15.18	72	140212	253809	79350295
Hyperammonaemia	235.10	15.18	178	140106	10915	79593189
Contraindicated product administered	234.17	15.18	10	140274	157528	79446576
Swelling	230.05	15.18	50	140234	216661	79387443
Decreased appetite	228.62	15.18	1197	139087	341221	79262883
Hyperammonaemic encephalopathy	226.20	15.18	127	140157	4655	79599449
Enterocolitis	225.07	15.18	194	140090	14318	79589786
Focal nodular hyperplasia	222.08	15.18	73	140211	669	79603435
Dysarthria	221.57	15.18	414	139870	67208	79536896
Anaphylactic shock	213.26	15.18	289	139995	35707	79568397
Cytokine release syndrome	213.25	15.18	289	139995	35709	79568395
Therapeutic product effect decreased	212.51	15.18	21	140263	163842	79440262
Splenomegaly	206.39	15.18	217	140067	20537	79583567
Depression	205.29	15.18	63	140221	216727	79387377
Ascites	199.88	15.18	423	139861	75139	79528965
Stomatitis	199.71	15.18	640	139644	146117	79457987
Hypomagnesaemia	199.12	15.18	322	139962	46589	79557515
Systemic lupus erythematosus	197.49	15.18	3	140281	121146	79482958
Product use issue	195.07	15.18	63	140221	209759	79394345
Abdominal discomfort	190.13	15.18	102	140182	250625	79353479
Insomnia	188.47	15.18	98	140186	245072	79359032
Drug interaction	186.52	15.18	276	140008	414907	79189197
Contusion	185.45	15.18	22	140262	148754	79455350
Abdominal pain	184.72	15.18	1245	139039	388324	79215780
Pain in extremity	184.42	15.18	222	140062	364316	79239788
Asthma	181.39	15.18	15	140269	135080	79469024
Dysphonia	172.51	15.18	337	139947	56535	79547569
Overdose	171.76	15.18	55	140229	184151	79419953
Anastomotic leak	170.97	15.18	66	140218	999	79603105
Maternal exposure during pregnancy	170.65	15.18	20	140264	136518	79467586
Metastases to peritoneum	169.38	15.18	102	140182	4270	79599834
Proteinuria	167.35	15.18	244	140040	32258	79571846
Influenza	167.02	15.18	17	140267	129589	79474515
Tumour perforation	165.59	15.18	51	140233	370	79603734
Nodular regenerative hyperplasia	165.32	15.18	69	140215	1292	79602812
Dyspnoea	164.98	15.18	2261	138023	854764	78749340
Asthenia	164.87	15.18	1495	138789	510194	79093910
Hyperhidrosis	162.05	15.18	610	139674	150882	79453222
Musculoskeletal stiffness	160.10	15.18	54	140230	174954	79429150
Arthritis	159.21	15.18	11	140273	114869	79489235
Colorectal cancer metastatic	157.94	15.18	65	140219	1173	79602931
Pyrexia	157.86	15.18	1855	138429	676854	78927250
Intestinal obstruction	156.94	15.18	276	140008	42744	79561360
Injection site pain	155.08	15.18	22	140262	129816	79474288
Pemphigus	152.50	15.18	5	140279	99577	79504527
Intentional product misuse	152.44	15.18	3	140281	95162	79508942
Hyperthermia	147.15	15.18	170	140114	17867	79586237
Varices oesophageal	146.95	15.18	105	140179	5886	79598218
Dysaesthesia	146.92	15.18	104	140180	5744	79598360
Laryngeal discomfort	143.96	15.18	50	140234	550	79603554
Psoriasis	142.80	15.18	3	140281	89584	79514520
Carcinoembryonic antigen increased	142.09	15.18	72	140212	2137	79601967
Oxygen saturation decreased	141.64	15.18	524	139760	128523	79475581
Bronchitis	140.94	15.18	29	140255	130615	79473489
Cardiac failure congestive	139.13	15.18	39	140245	142363	79461741
Osteoarthritis	138.87	15.18	3	140281	87306	79516798
Feeling hot	138.26	15.18	317	139967	59417	79544687
Anxiety	138.07	15.18	140	140144	248372	79355732
Glossodynia	137.28	15.18	12	140272	103325	79500779
Lower respiratory tract infection	134.69	15.18	31	140253	129189	79474915
Laryngeal oedema	132.86	15.18	112	140172	8017	79596087
Drug intolerance	131.21	15.18	163	140121	263956	79340148
Dehydration	130.81	15.18	815	139469	247372	79356732
Hypersensitivity	130.72	15.18	849	139435	261390	79342714
Blood cholesterol increased	128.93	15.18	4	140280	83716	79520388
Pneumonia	128.78	15.18	661	139623	659585	78944519
Large intestine perforation	128.53	15.18	143	140141	14424	79589680
Suicide attempt	127.58	15.18	4	140280	82928	79521176
Immune thrombocytopenia	127.45	15.18	157	140127	17648	79586456
Hospitalisation	125.02	15.18	11	140273	94225	79509879
Posterior reversible encephalopathy syndrome	124.84	15.18	190	140094	26091	79578013
Hepatic enzyme increased	122.11	15.18	86	140198	182524	79421580
Stress	121.89	15.18	4	140280	79608	79524496
Somnolence	121.33	15.18	145	140139	238836	79365268
Wound	120.83	15.18	28	140256	116151	79487953
Stomal varices	119.23	15.18	29	140255	71	79604033
Pneumatosis intestinalis	118.93	15.18	95	140189	6302	79597802
Myalgia	116.96	15.18	93	140191	185548	79418556
Condition aggravated	116.56	15.18	470	139814	500654	79103450
Exposure during pregnancy	114.29	15.18	20	140264	101112	79502992
Inappropriate schedule of product administration	114.16	15.18	46	140238	133582	79470522
Hypertensive crisis	112.88	15.18	160	140124	20610	79583494
Toxic leukoencephalopathy	112.24	15.18	50	140234	1104	79603000
Paraesthesia oral	111.71	15.18	158	140126	20313	79583791
Skin reaction	110.71	15.18	139	140145	15929	79588175
Tumour necrosis	110.24	15.18	58	140226	1864	79602240
Ileus	108.61	15.18	178	140106	26033	79578071
Rash pustular	108.44	15.18	116	140168	11195	79592909
Intravascular haemolysis	107.32	15.18	44	140240	786	79603318
Extravasation	106.70	15.18	72	140212	3678	79600426
Peritonitis	105.02	15.18	182	140102	27854	79576250
Memory impairment	104.77	15.18	33	140251	111701	79492403
General physical health deterioration	102.49	15.18	831	139453	274407	79329697
Disseminated intravascular coagulation	102.20	15.18	207	140077	35635	79568469
Intestinal perforation	101.82	15.18	139	140145	17287	79586817
Hypertransaminasaemia	101.69	15.18	115	140169	11809	79592295
Injection site erythema	101.41	15.18	10	140274	78187	79525917
Pericarditis	100.97	15.18	29	140255	104207	79499897
Mobility decreased	99.67	15.18	45	140239	122130	79481974
Acute coronary syndrome	99.27	15.18	152	140132	20981	79583123
Helicobacter infection	98.57	15.18	6	140278	69698	79534406
Confusional state	98.23	15.18	263	140021	317734	79286370
Cholinergic syndrome	95.90	15.18	44	140240	1043	79603061
Suicidal ideation	95.83	15.18	11	140273	76329	79527775
Migraine	95.23	15.18	19	140265	87474	79516630
Platelet count decreased	94.96	15.18	627	139657	194037	79410067
Hypokalaemia	94.13	15.18	501	139783	143539	79460565
Dihydropyrimidine dehydrogenase deficiency	93.62	15.18	26	140258	124	79603980
Administration site extravasation	92.94	15.18	46	140238	1297	79602807
Anaphylactic reaction	91.81	15.18	340	139944	83403	79520701
Drug hypersensitivity	91.73	15.18	248	140036	298668	79305436
Haemolytic anaemia	90.60	15.18	133	140151	17687	79586417
Tumour lysis syndrome	90.44	15.18	156	140128	23783	79580321
Portal shunt	90.41	15.18	22	140262	54	79604050
Tongue oedema	90.34	15.18	85	140199	7032	79597072
Treatment failure	89.13	15.18	101	140183	170385	79433719
Incorrect dose administered	86.92	15.18	15	140269	76615	79527489
Off label use	85.65	15.18	2143	138141	905072	78699032
Upper respiratory tract infection	85.34	15.18	27	140257	91141	79512963
Mucosal toxicity	85.12	15.18	34	140250	566	79603538
Anaemia	83.51	15.18	1170	139114	443845	79160259
Blood pressure fluctuation	83.47	15.18	10	140274	67135	79536969
Fluid retention	82.94	15.18	12	140272	69797	79534307
Band sensation	82.64	15.18	36	140248	752	79603352
Rhabdomyolysis	82.54	15.18	39	140245	103092	79501012
Chronic obstructive pulmonary disease	82.30	15.18	24	140260	85395	79518709
Duodenal ulcer perforation	81.97	15.18	10	140274	66201	79537903
Osteoporosis	81.85	15.18	3	140281	54109	79549995
Diffuse large B-cell lymphoma recurrent	81.48	15.18	64	140220	4143	79599961
Blister	80.20	15.18	56	140228	119420	79484684
Anastomotic fistula	80.02	15.18	23	140261	127	79603977
Tachycardia	79.21	15.18	560	139724	177208	79426896
Leukoencephalopathy	78.99	15.18	83	140201	7846	79596258
Metastases to lymph nodes	78.18	15.18	94	140190	10303	79593801
Rectal perforation	77.86	15.18	36	140248	869	79603235
Injection site reaction	76.61	15.18	5	140279	54780	79549324
Discomfort	76.53	15.18	65	140219	125552	79478552
Aggression	76.48	15.18	3	140281	50955	79553149
Sleep disorder	75.64	15.18	28	140256	85649	79518455
Anastomotic complication	75.00	15.18	29	140255	441	79603663
Pulmonary embolism	74.30	15.18	537	139747	171117	79432987
Electrocardiogram QT prolonged	74.17	15.18	33	140251	90353	79513751
Hallucination	74.07	15.18	29	140255	85716	79518388
Electrocardiogram ST segment elevation	73.34	15.18	82	140202	8315	79595789
Subileus	72.68	15.18	68	140216	5586	79598518
Cyanosis	72.46	15.18	146	140138	25036	79579068
Septic shock	72.11	15.18	415	139869	122386	79481718
Feeling abnormal	71.18	15.18	106	140178	159093	79445011
Ocular toxicity	69.48	15.18	33	140251	848	79603256
Hiccups	69.46	15.18	87	140197	9944	79594160
Sedation	68.98	15.18	6	140278	51889	79552215
Cholangitis	68.81	15.18	98	140186	12678	79591426
Myocardial infarction	68.29	15.18	138	140146	183991	79420113
Vascular pain	68.29	15.18	33	140251	882	79603222
Colon cancer metastatic	67.18	15.18	44	140240	2137	79601967
Blood glucose increased	67.02	15.18	62	140222	114913	79489191
Metastasis	66.73	15.18	71	140213	6809	79597295
Dizziness	66.49	15.18	599	139685	525842	79078262
Evans syndrome	66.09	15.18	26	140258	415	79603689
Nicotinic acid deficiency	66.07	15.18	21	140263	171	79603933
Stress cardiomyopathy	65.13	15.18	89	140195	11077	79593027
Gastric perforation	64.69	15.18	55	140229	3982	79600122
Palmar erythema	64.21	15.18	41	140243	1906	79602198
Coronary artery disease	63.80	15.18	18	140266	65456	79538648
Neuromyotonia	63.62	15.18	18	140266	93	79604011
Cellulitis	63.35	15.18	59	140225	109001	79495103
Herpes zoster	63.30	15.18	43	140241	93040	79511064
Illness	62.87	15.18	5	140279	46506	79557598
Dysphagia	62.34	15.18	398	139886	121738	79482366
Hyperbilirubinaemia	62.20	15.18	135	140149	24383	79579721
Injection site pruritus	61.77	15.18	3	140281	42280	79561824
Medication error	61.33	15.18	22	140262	68620	79535484
Nasal congestion	61.18	15.18	29	140255	76523	79527581
Hypoalbuminaemia	60.71	15.18	123	140161	21174	79582930
Wrong technique in product usage process	60.57	15.18	27	140257	73848	79530256
Choking sensation	60.12	15.18	52	140232	3854	79600250
Hepatic failure	60.09	15.18	240	140044	60972	79543132
Stoma site haemorrhage	59.87	15.18	39	140245	1877	79602227
Treatment noncompliance	59.79	15.18	10	140274	52258	79551846
Diffuse large B-cell lymphoma refractory	59.56	15.18	35	140249	1400	79602704
Drug dependence	59.21	15.18	3	140281	40766	79563338
Influenza like illness	59.12	15.18	26	140258	71681	79532423
Gait disturbance	58.60	15.18	179	140105	207327	79396777
Infusion related hypersensitivity reaction	58.07	15.18	23	140261	374	79603730
Urinary tract infection	57.86	15.18	267	140017	274245	79329859
Drug level increased	57.33	15.18	3	140281	39648	79564456
Type 2 diabetes mellitus	56.98	15.18	15	140269	57107	79546997
Chemical peritonitis	56.82	15.18	21	140263	280	79603824
Laryngeal dyspnoea	56.82	15.18	21	140263	280	79603824
Oesophageal varices haemorrhage	56.48	15.18	52	140232	4184	79599920
International normalised ratio increased	56.47	15.18	40	140244	84681	79519423
Colitis	56.34	15.18	267	140017	73040	79531064
ECG signs of myocardial ischaemia	56.34	15.18	22	140262	344	79603760
Vocal cord paralysis	55.89	15.18	42	140242	2545	79601559
Hepatic atrophy	55.73	15.18	23	140261	418	79603686
Encapsulating peritoneal sclerosis	55.50	15.18	28	140256	823	79603281
Large intestinal obstruction	55.04	15.18	46	140238	3253	79600851
Speech disorder	54.68	15.18	215	140069	54230	79549874
Productive cough	54.67	15.18	45	140239	88286	79515818
Psychotic disorder	54.46	15.18	5	140279	41397	79562707
Hyperpyrexia	54.08	15.18	60	140224	6032	79598072
Gastrointestinal anastomotic leak	54.04	15.18	24	140260	526	79603578
Hypervolaemia	53.95	15.18	6	140278	42684	79561420
Drug reaction with eosinophilia and systemic symptoms	53.43	15.18	23	140261	64221	79539883
Skin fissures	53.10	15.18	88	140196	12985	79591119
Loss of personal independence in daily activities	52.27	15.18	62	140222	102518	79501586
Intentional product use issue	52.24	15.18	119	140165	151993	79452111
Enterovesical fistula	52.16	15.18	30	140254	1152	79602952
Viral infection	52.03	15.18	7	140277	43009	79561095
Trichomegaly	51.96	15.18	16	140268	116	79603988
Hepatocellular injury	51.95	15.18	193	140091	47400	79556704
Cough	51.36	15.18	406	139878	366383	79237721
Prinzmetal angina	51.28	15.18	34	140250	1686	79602418
Heart rate decreased	51.23	15.18	30	140254	70286	79533818
Necrotising fasciitis	50.99	15.18	58	140226	5992	79598112
Anaphylactoid reaction	50.91	15.18	55	140229	5367	79598737
Road traffic accident	50.73	15.18	8	140276	43656	79560448
Recall phenomenon	50.55	15.18	29	140255	1108	79602996
Trismus	50.53	15.18	55	140229	5412	79598692
Cataract	50.46	15.18	23	140261	62097	79542007
Infusion related reaction	50.46	15.18	623	139661	229614	79374490
Splenorenal shunt	50.23	15.18	11	140273	13	79604091
Pulmonary toxicity	49.89	15.18	85	140199	12829	79591275
Blood pressure systolic increased	49.63	15.18	28	140256	66958	79537146
Metastases to meninges	49.57	15.18	45	140239	3556	79600548
Emotional distress	49.56	15.18	6	140278	39963	79564141
Dysgeusia	48.95	15.18	215	140069	56962	79547142
Small intestinal perforation	48.95	15.18	43	140241	3254	79600850
White blood cell count decreased	48.63	15.18	526	139758	187762	79416342
Wound dehiscence	48.57	15.18	59	140225	6536	79597568
Ileal perforation	47.88	15.18	27	140257	998	79603106
Head injury	47.87	15.18	5	140279	37364	79566740
Tachypnoea	47.40	15.18	144	140140	31919	79572185
Metastases to spleen	47.38	15.18	23	140261	621	79603483
Enterocutaneous fistula	47.25	15.18	34	140250	1927	79602177
Portal venous gas	47.08	15.18	20	140264	392	79603712
Rhinorrhoea	46.77	15.18	39	140245	76035	79528069
Acute abdomen	46.75	15.18	41	140243	3096	79601008
Malignant ascites	46.67	15.18	28	140256	1164	79602940
Hyperkalaemia	46.58	15.18	81	140203	114317	79489787
Metastases to ovary	46.41	15.18	19	140265	338	79603766
Transdifferentiation of neoplasm	46.39	15.18	14	140270	94	79604010
Liver function test abnormal	46.28	15.18	28	140256	64447	79539657
Portal vein thrombosis	45.99	15.18	54	140230	5773	79598331
Formication	45.50	15.18	50	140234	4973	79599131
Neutropenic sepsis	45.24	15.18	127	140157	26937	79577167
Biliary tract infection	45.21	15.18	29	140255	1359	79602745
Hypercreatinaemia	45.04	15.18	18	140266	300	79603804
Sensation of foreign body	44.96	15.18	52	140232	5470	79598634
Metastases to bone marrow	44.87	15.18	24	140260	798	79603306
Diabetes mellitus	44.82	15.18	43	140241	78347	79525757
Thrombocytopenic purpura	44.48	15.18	36	140248	2433	79601671
Temperature intolerance	44.45	15.18	69	140215	9636	79594468
Obesity	44.23	15.18	5	140279	35120	79568984
Cold sweat	44.10	15.18	100	140184	18599	79585505
Blood lactate dehydrogenase increased	43.72	15.18	160	140124	39010	79565094
Drug withdrawal syndrome	43.57	15.18	5	140279	34713	79569391
Fatigue	43.50	15.18	1275	139009	928452	78675652
Balance disorder	43.04	15.18	67	140217	98790	79505314
Haemoglobinuria	42.91	15.18	23	140261	768	79603336
Hypertension	42.87	15.18	819	139465	330173	79273931
Oxygen saturation normal	42.76	15.18	8	140276	0	79604104
Performance status decreased	42.30	15.18	53	140231	6060	79598044
Hypertrichosis	42.29	15.18	27	140257	1255	79602849
Hypotension	42.16	15.18	1043	139241	439274	79164830
Adverse event	42.04	15.18	27	140257	60187	79543917
Gene mutation	41.83	15.18	36	140248	2650	79601454
Periportal sinus dilatation	41.77	15.18	14	140270	137	79603967
Oropharyngeal discomfort	41.62	15.18	57	140227	7109	79596995
Type II hypersensitivity	41.57	15.18	11	140273	42	79604062
Acute respiratory distress syndrome	41.04	15.18	170	140114	43897	79560207
Basal cell carcinoma	40.91	15.18	8	140276	37367	79566737
Adverse drug reaction	40.86	15.18	34	140250	66358	79537746
Steatohepatitis	40.70	15.18	24	140260	966	79603138
Hallucination, visual	40.37	15.18	5	140279	32724	79571380
Embolism	40.15	15.18	81	140203	13901	79590203
Unevaluable event	40.09	15.18	24	140260	55561	79548543
Amaurosis fugax	40.06	15.18	23	140261	880	79603224
Oedema peripheral	39.74	15.18	270	140014	252018	79352086
Perforation	39.67	15.18	27	140257	1399	79602705
Hepatic function abnormal	39.64	15.18	242	140042	72865	79531239
Pharyngeal paraesthesia	39.42	15.18	35	140249	2686	79601418
Gastric varices haemorrhage	39.26	15.18	18	140266	426	79603678
Gait inability	39.02	15.18	28	140256	58889	79545215
Alopecia	38.77	15.18	243	140041	231112	79372992
Neutropenic colitis	38.72	15.18	49	140235	5658	79598446
Peripheral motor neuropathy	38.56	15.18	38	140246	3329	79600775
Haematemesis	38.45	15.18	188	140096	52076	79552028
Chest discomfort	38.15	15.18	391	139893	137653	79466451
Liver abscess	37.98	15.18	50	140234	6004	79598100
Aortic thrombosis	37.70	15.18	28	140256	1667	79602437
Prescribed underdose	37.68	15.18	4	140280	29510	79574594
Abortion spontaneous	37.66	15.18	4	140280	29503	79574601
Abnormal behaviour	37.42	15.18	9	140275	36412	79567692
Cold dysaesthesia	37.23	15.18	8	140276	8	79604096
Oropharyngeal pain	37.17	15.18	86	140198	109267	79494837
Irritability	37.07	15.18	13	140271	41131	79562973
Intestinal ischaemia	37.06	15.18	76	140208	13194	79590910
Haematoma	37.00	15.18	23	140261	52172	79551932
Neck pain	36.92	15.18	47	140237	75370	79528734
Oesophagitis	36.76	15.18	110	140174	24179	79579925
Peripheral nerve injury	36.61	15.18	20	140264	694	79603410
Cardiac disorder	36.52	15.18	37	140247	65720	79538384
Eosinophilia	36.50	15.18	17	140267	45328	79558776
Underdose	36.49	15.18	7	140277	33144	79570960
Peripheral sensorimotor neuropathy	36.40	15.18	35	140249	2975	79601129
Factor VII deficiency	36.18	15.18	9	140275	25	79604079
Hypophagia	36.14	15.18	167	140117	45200	79558904
Full blood count abnormal	36.11	15.18	13	140271	40461	79563643
Ear pain	36.05	15.18	7	140277	32862	79571242
Aortitis	36.01	15.18	26	140258	1481	79602623
Withdrawal syndrome	35.98	15.18	3	140281	26851	79577253
Congestive cardiomyopathy	35.94	15.18	70	140214	11710	79592394
Impaired healing	35.74	15.18	62	140222	87593	79516511
Nephrolithiasis	35.72	15.18	25	140259	53266	79550838
K-ras gene mutation	35.45	15.18	10	140274	51	79604053
Small intestinal obstruction	35.30	15.18	117	140167	27155	79576949
COVID-19	35.22	15.18	150	140134	157524	79446580
Hypovolaemic shock	35.11	15.18	71	140213	12205	79591899
Portal vein dilatation	34.98	15.18	10	140274	54	79604050
Colitis ulcerative	34.89	15.18	9	140275	34733	79569371
Nervousness	34.84	15.18	8	140276	33407	79570697
Accidental overdose	34.82	15.18	13	140271	39568	79564536
Oesophageal haemorrhage	34.48	15.18	27	140257	1740	79602364
Jaundice	34.43	15.18	185	140099	53164	79550940
Splenic artery thrombosis	34.38	15.18	10	140274	58	79604046
Hepatectomy	34.21	15.18	13	140271	188	79603916
Granulocyte count decreased	33.93	15.18	27	140257	1781	79602323
Femur fracture	33.50	15.18	13	140271	38639	79565465
Disease recurrence	32.69	15.18	159	140125	43950	79560154
Hepatic lesion	32.60	15.18	50	140234	6909	79597195
Cytopenia	32.46	15.18	94	140190	20289	79583815
Blood pressure immeasurable	32.36	15.18	28	140256	2076	79602028
Thrombotic microangiopathy	32.11	15.18	93	140191	20076	79584028
Hypoglycaemia	32.09	15.18	83	140201	101511	79502593
Noninfective epididymitis	32.07	15.18	6	140278	0	79604104
Lip oedema	31.90	15.18	47	140237	6269	79597835
Cholestasis	31.82	15.18	178	140106	51931	79552173
Heart rate irregular	31.81	15.18	9	140275	32670	79571434
Therapy interrupted	31.70	15.18	8	140276	31333	79572771
Night sweats	31.66	15.18	27	140257	52068	79552036
Respiratory distress	31.55	15.18	193	140091	58146	79545958
Device issue	31.42	15.18	5	140279	27103	79577001
Gastrooesophageal reflux disease	30.80	15.18	88	140196	104158	79499946
Sciatica	30.80	15.18	10	140274	33212	79570892
Toxicity to various agents	30.74	15.18	539	139745	421001	79183103
Guillain-Barre syndrome	30.74	15.18	56	140228	8909	79595195
Oral dysaesthesia	30.65	15.18	12	140272	189	79603915
Musculoskeletal pain	30.54	15.18	86	140198	102268	79501836
Osteomyelitis	30.28	15.18	10	140274	32855	79571249
Hydronephrosis	30.25	15.18	83	140201	17371	79586733
Gastrointestinal obstruction	30.17	15.18	25	140259	1747	79602357
Biliary fistula	30.10	15.18	10	140274	95	79604009
Skin laceration	30.06	15.18	7	140277	28955	79575149
Tooth disorder	30.04	15.18	5	140279	26228	79577876
Blood pressure diastolic decreased	30.01	15.18	8	140276	30208	79573896
Muscle contractions involuntary	29.89	15.18	35	140249	3730	79600374
Haemolytic uraemic syndrome	29.87	15.18	38	140246	4411	79599693
Haemolysis	29.64	15.18	68	140216	12744	79591360
Right ventricular ejection fraction decreased	29.62	15.18	9	140275	62	79604042
Autoimmune haemolytic anaemia	29.57	15.18	53	140231	8327	79595777
Perforation bile duct	29.55	15.18	8	140276	34	79604070
Bursitis	29.54	15.18	13	140271	35831	79568273
Appendicitis noninfective	29.42	15.18	7	140277	15	79604089
Short-bowel syndrome	29.35	15.18	16	140268	553	79603551
Dysentery	29.33	15.18	21	140263	1181	79602923
Retching	29.23	15.18	82	140202	17385	79586719
Poor quality sleep	29.21	15.18	3	140281	22719	79581385
Rectal cancer metastatic	29.12	15.18	15	140269	461	79603643
Limb injury	28.99	15.18	8	140276	29520	79574584
Pulmonary sarcoidosis	28.96	15.18	22	140262	1355	79602749
Pelvic fluid collection	28.90	15.18	18	140266	801	79603303
Localised infection	28.86	15.18	15	140269	37560	79566544
Loss of consciousness	28.80	15.18	435	139849	167508	79436596
Failure to anastomose	28.78	15.18	12	140272	224	79603880
Pulmonary artery thrombosis	28.75	15.18	22	140262	1370	79602734
Suffocation feeling	28.73	15.18	24	140260	1696	79602408
Cytomegalovirus infection	28.59	15.18	20	140264	42624	79561480
Blood creatine phosphokinase increased	28.57	15.18	45	140239	66045	79538059
Tendonitis	28.53	15.18	4	140280	23826	79580278
Oedema	28.44	15.18	111	140173	119469	79484635
Sciatic nerve palsy	27.92	15.18	9	140275	77	79604027
Blood glucose decreased	27.92	15.18	6	140278	26228	79577876
Post embolisation syndrome	27.62	15.18	9	140275	80	79604024
Infection	27.47	15.18	282	140002	241430	79362674
Medical device site extravasation	27.44	15.18	6	140278	7	79604097
Cystitis radiation	27.27	15.18	11	140273	188	79603916
Amnesia	27.19	15.18	43	140241	63014	79541090
Koebner phenomenon	27.14	15.18	8	140276	49	79604055
Inflammation	27.08	15.18	80	140204	93673	79510431
Heat stroke	26.88	15.18	23	140261	1680	79602424
Type III immune complex mediated reaction	26.74	15.18	16	140268	662	79603442
Mucosal disorder	26.69	15.18	32	140252	3496	79600608
Carbohydrate antigen 19-9 increased	26.58	15.18	14	140270	451	79603653
Dry eye	26.56	15.18	16	140268	36915	79567189
Hyperaemia	26.53	15.18	30	140254	3080	79601024
Sinus bradycardia	26.41	15.18	6	140278	25241	79578863
Perineal disorder	26.40	15.18	7	140277	27	79604077
Hypoacusis	26.36	15.18	10	140274	30140	79573964
Labelled drug-drug interaction medication error	26.21	15.18	8	140276	27642	79576462
Hypersplenism	26.15	15.18	15	140269	573	79603531
Gastrointestinal necrosis	26.10	15.18	40	140244	5525	79598579
Multiple sclerosis	26.07	15.18	4	140280	22278	79581826
Respiratory arrest	26.02	15.18	38	140246	57512	79546592
Pelvic abscess	26.01	15.18	25	140259	2124	79601980
Hyperfibrinolysis	26.00	15.18	7	140277	29	79604075
Venoocclusive disease	25.99	15.18	36	140248	4537	79599567
Pharyngeal dyskinesia	25.98	15.18	8	140276	58	79604046
Intervertebral disc protrusion	25.97	15.18	5	140279	23616	79580488
Hallucination, auditory	25.92	15.18	3	140281	20690	79583414
Vasospasm	25.82	15.18	19	140265	1115	79602989
Adenocarcinoma	25.79	15.18	33	140251	3853	79600251
Injection site paraesthesia	25.66	15.18	15	140269	594	79603510
Heart rate increased	25.65	15.18	117	140167	120607	79483497
Pulmonary hypertension	25.64	15.18	28	140256	48052	79556052
Pain in jaw	25.59	15.18	26	140258	46125	79557979
Hepatic encephalopathy	25.54	15.18	97	140187	24069	79580035
Endothelial dysfunction	25.33	15.18	11	140273	228	79603876
Hypoaesthesia oral	25.32	15.18	68	140216	14056	79590048
Product substitution issue	25.21	15.18	3	140281	20253	79583851
Hypercholesterolaemia	25.16	15.18	5	140279	23090	79581014
Hypersomnia	25.14	15.18	5	140279	23081	79581023
Swelling face	25.02	15.18	55	140229	71157	79532947
Eczema	25.00	15.18	21	140263	40797	79563307
Full blood count decreased	24.99	15.18	8	140276	26811	79577293
Liver function test increased	24.93	15.18	20	140264	39753	79564351
Toxic epidermal necrolysis	24.85	15.18	25	140259	44556	79559548
Subacute cutaneous lupus erythematosus	24.84	15.18	31	140253	3530	79600574
Thrombotic thrombocytopenic purpura	24.67	15.18	42	140242	6334	79597770
Gastric disorder	24.51	15.18	18	140266	37415	79566689
Nephrotic syndrome	24.42	15.18	58	140226	11116	79592988
Tumour ulceration	24.40	15.18	11	140273	250	79603854
Abdominal wall oedema	24.38	15.18	5	140279	3	79604101
Pseudocirrhosis	24.13	15.18	15	140269	665	79603439
Tumour haemorrhage	24.12	15.18	33	140251	4111	79599993
Platelet count increased	24.10	15.18	5	140279	22401	79581703
Papilloedema	24.04	15.18	41	140243	6192	79597912
Colon cancer recurrent	23.95	15.18	9	140275	126	79603978
Metastases to muscle	23.93	15.18	12	140272	348	79603756
Bronchostenosis	23.91	15.18	15	140269	676	79603428
Surgery	23.84	15.18	14	140270	32752	79571352
Fistula of small intestine	23.82	15.18	16	140268	811	79603293
Gout	23.75	15.18	7	140277	24742	79579362
Gallbladder disorder	23.74	15.18	3	140281	19337	79584767
Neoplasm recurrence	23.69	15.18	33	140251	4181	79599923
Cachexia	23.65	15.18	57	140227	11026	79593078
Device related infection	23.56	15.18	121	140163	34173	79569931
Blood potassium increased	23.53	15.18	11	140273	29264	79574840
Neutropenic infection	23.46	15.18	25	140259	2402	79601702
Dry mouth	23.38	15.18	78	140206	87941	79516163
Fulminant type 1 diabetes mellitus	23.35	15.18	20	140264	1463	79602641
Immune effector cell-associated neurotoxicity syndrome	23.26	15.18	39	140245	5809	79598295
Acute promyelocytic leukaemia	23.25	15.18	20	140264	1471	79602633
Acute polyneuropathy	23.14	15.18	13	140271	477	79603627
Immunodeficiency	23.12	15.18	5	140279	21763	79582341
Tonic clonic movements	23.09	15.18	24	140260	2240	79601864
Wheezing	23.08	15.18	116	140168	116548	79487556
Pigmentation disorder	23.06	15.18	38	140246	5580	79598524
Death	22.99	15.18	791	139493	565723	79038381
Gastric varices	22.95	15.18	15	140269	726	79603378
Acral peeling skin syndrome	22.94	15.18	7	140277	49	79604055
Skin discolouration	22.89	15.18	23	140261	41011	79563093
Skin disorder	22.79	15.18	119	140165	33824	79570280
Pneumatosis	22.77	15.18	16	140268	873	79603231
Pneumonitis	22.72	15.18	184	140100	60676	79543428
Protein urine	22.67	15.18	20	140264	1522	79602582
Rectal cancer recurrent	22.66	15.18	6	140278	23	79604081
Necrotic lymphadenopathy	22.64	15.18	8	140276	93	79604011
Musculoskeletal disorder	22.63	15.18	5	140279	21443	79582661
Gastrointestinal mucosal necrosis	22.48	15.18	10	140274	220	79603884
Delirium	22.47	15.18	75	140209	84552	79519552
Toothache	22.44	15.18	4	140280	19966	79584138
Retroperitoneal abscess	22.43	15.18	12	140272	399	79603705
Haemorrhage intracranial	22.39	15.18	9	140275	26184	79577920
Hypothyroidism	22.34	15.18	36	140248	52356	79551748
Renal hydrocele	22.26	15.18	6	140278	25	79604079
Musculoskeletal discomfort	22.23	15.18	4	140280	19831	79584273
Eye pain	22.20	15.18	20	140264	37558	79566546
Obstruction gastric	22.20	15.18	21	140263	1749	79602355
Back pain	22.14	15.18	389	139895	303791	79300313
Hyperlipasaemia	21.99	15.18	18	140266	1236	79602868
Gastrointestinal stoma complication	21.75	15.18	25	140259	2612	79601492
Astringent therapy	21.71	15.18	6	140278	28	79604076
Eczema impetiginous	21.71	15.18	6	140278	28	79604076
Fingerprint loss	21.71	15.18	7	140277	60	79604044
Oropharyngeal spasm	21.67	15.18	12	140272	428	79603676
Perihepatic abscess	21.54	15.18	9	140275	169	79603935
Tumour fistulisation	21.54	15.18	6	140278	29	79604075
Oesophagobronchial fistula	21.45	15.18	10	140274	246	79603858
Livedo reticularis	21.40	15.18	31	140253	4072	79600032
Diaphragmatic operation	21.37	15.18	6	140278	30	79604074
Abdominal abscess	21.32	15.18	42	140242	7085	79597019
Procedural pain	21.31	15.18	7	140277	23077	79581027
Product administration error	21.26	15.18	15	140269	31831	79572273
Ischiorectal hernia	21.25	15.18	5	140279	10	79604094
Hand-foot-genital syndrome	21.25	15.18	5	140279	10	79604094
Hepatic vein stenosis	21.21	15.18	7	140277	65	79604039
Interventricular septum rupture	21.21	15.18	6	140278	31	79604073
Catheter site extravasation	21.19	15.18	12	140272	447	79603657
Sepsis	21.11	15.18	622	139662	268806	79335298
Cardiomegaly	21.02	15.18	10	140274	26342	79577762
Colorectal cancer recurrent	21.02	15.18	7	140277	67	79604037
Organising pneumonia	20.97	15.18	54	140230	10885	79593219
Adenocarcinoma metastatic	20.93	15.18	9	140275	182	79603922
Feeling cold	20.88	15.18	103	140181	28626	79575478
Pneumonitis chemical	20.88	15.18	12	140272	460	79603644
Cardiac ventricular disorder	20.86	15.18	11	140273	355	79603749
Microangiopathic haemolytic anaemia	20.86	15.18	19	140265	1508	79602596
Product prescribing error	20.84	15.18	29	140255	44784	79559320
Adenocarcinoma of colon	20.78	15.18	36	140248	5505	79598599
Transient aphasia	20.69	15.18	12	140272	468	79603636
Limbic encephalitis	20.69	15.18	15	140269	860	79603244
Stomal hernia	20.67	15.18	11	140273	362	79603742
Atypical haemolytic uraemic syndrome	20.64	15.18	16	140268	1016	79603088
Mucosal necrosis	20.61	15.18	8	140276	123	79603981
Blood alkaline phosphatase abnormal	20.58	15.18	15	140269	867	79603237
Restless legs syndrome	20.57	15.18	5	140279	20087	79584017
Pulmonary congestion	20.55	15.18	11	140273	27089	79577015
Acute myeloid leukaemia	20.54	15.18	108	140176	30777	79573327
Rectosigmoid cancer	20.50	15.18	10	140274	273	79603831
Neutrophil count abnormal	20.41	15.18	28	140256	3498	79600606
Therapeutic response unexpected	20.35	15.18	5	140279	19941	79584163
C-reactive protein increased	20.34	15.18	138	140146	128889	79475215
Disability	20.20	15.18	3	140281	17117	79586987
Premature delivery	20.16	15.18	8	140276	23459	79580645
Hernia	20.10	15.18	3	140281	17056	79587048
Hepatic infarction	20.09	15.18	15	140269	900	79603204
Pneumoperitoneum	20.01	15.18	26	140258	3082	79601022
Epistaxis	19.95	15.18	291	139993	111224	79492880
Osteopenia	19.95	15.18	4	140280	18360	79585744
Hiatus hernia	19.94	15.18	8	140276	23304	79580800
Therapy non-responder	19.88	15.18	89	140195	92216	79511888
Hypocapnia	19.87	15.18	13	140271	630	79603474
Drug eruption	19.87	15.18	29	140255	43906	79560198
Prostatic calcification	19.68	15.18	7	140277	83	79604021
Palpitations	19.67	15.18	136	140148	126474	79477630
Allodynia	19.62	15.18	19	140265	1629	79602475
Diaphragmatic paralysis	19.58	15.18	16	140268	1096	79603008
Chronic myeloid leukaemia	19.57	15.18	28	140256	3636	79600468
Necrotising oesophagitis	19.57	15.18	16	140268	1097	79603007
Grip strength decreased	19.55	15.18	7	140277	21862	79582242
Venous thrombosis limb	19.46	15.18	31	140253	4426	79599678
Sputum discoloured	19.37	15.18	7	140277	21736	79582368
Mental disorder	19.30	15.18	16	140268	31286	79572818
Metastases to diaphragm	19.19	15.18	6	140278	46	79604058
Mucocutaneous rash	19.08	15.18	6	140278	47	79604057
Urticaria	19.07	15.18	221	140063	184980	79419124
Extrapyramidal disorder	19.05	15.18	8	140276	22671	79581433
Laboratory test abnormal	19.01	15.18	13	140271	28035	79576069
Mental impairment	18.98	15.18	5	140279	19031	79585073
Catabolic state	18.96	15.18	7	140277	93	79604011
Gastric stenosis	18.92	15.18	8	140276	155	79603949
Chemotherapy cardiotoxicity attenuation	18.91	15.18	5	140279	19	79604085
Mixed adenoneuroendocrine carcinoma	18.91	15.18	5	140279	19	79604085
Monocytopenia	18.87	15.18	8	140276	156	79603948
Anal sphincter atony	18.82	15.18	10	140274	328	79603776
Seizure	18.80	15.18	227	140057	188607	79415497
Macroglossia	18.74	15.18	16	140268	1165	79602939
Tremor	18.73	15.18	411	139873	169672	79434432
Axonal and demyelinating polyneuropathy	18.71	15.18	5	140279	20	79604084
Dementia	18.71	15.18	10	140274	24649	79579455
Induration	18.68	15.18	20	140264	1932	79602172
Inferior vena cava stenosis	18.65	15.18	6	140278	51	79604053
Neonatal asphyxia	18.61	15.18	4	140280	4	79604100
Intrahepatic portal hepatic venous fistula	18.61	15.18	4	140280	4	79604100
Live birth	18.55	15.18	5	140279	18739	79585365
Retroperitoneal mass	18.47	15.18	9	140275	245	79603859
Peripheral ischaemia	18.45	15.18	47	140237	9410	79594694
No adverse event	18.39	15.18	23	140261	37169	79566935
Blood triglycerides increased	18.36	15.18	7	140277	21033	79583071
Oesophageal fistula	18.32	15.18	11	140273	458	79603646
Cystitis	18.30	15.18	41	140243	52691	79551413
Obstructive airways disorder	18.28	15.18	17	140267	31442	79572662
Testicular disorder	18.14	15.18	9	140275	255	79603849
Intervertebral disc degeneration	18.10	15.18	3	140281	15782	79588322
Chronic kidney disease	18.00	15.18	58	140226	66096	79538008
Pulmonary oedema	17.88	15.18	87	140197	88167	79515937
Renal disorder	17.88	15.18	29	140255	42076	79562028
Ankle fracture	17.81	15.18	4	140280	16965	79587139
Endometrial dysplasia	17.81	15.18	5	140279	25	79604079
Angioedema	17.80	15.18	71	140213	75964	79528140
Radiation interaction	17.79	15.18	6	140278	60	79604044
Gastritis	17.75	15.18	36	140248	47957	79556147
Metastases to central nervous system	17.53	15.18	66	140218	16309	79587795
Pachymeningitis	17.46	15.18	9	140275	277	79603827
Growth of eyelashes	17.42	15.18	8	140276	190	79603914
VIth nerve disorder	17.34	15.18	5	140279	28	79604076
Aplastic anaemia	17.30	15.18	5	140279	17900	79586204
Metastases to retroperitoneum	17.15	15.18	10	140274	394	79603710
Pancreatic neuroendocrine tumour metastatic	17.13	15.18	7	140277	124	79603980
Dry skin	17.09	15.18	189	140095	67806	79536298
Lymphangiosis carcinomatosa	17.06	15.18	20	140264	2134	79601970
Jaw operation	16.90	15.18	13	140271	816	79603288
Pulmonary fibrosis	16.81	15.18	134	140150	43978	79560126
Pruritus	16.79	15.18	852	139432	393796	79210308
Xeroderma	16.72	15.18	9	140275	303	79603801
Movement disorder	16.72	15.18	14	140270	27245	79576859
Mood swings	16.72	15.18	7	140277	19873	79584231
Lacrimation disorder	16.68	15.18	4	140280	9	79604095
Blindness transient	16.59	15.18	30	140254	4746	79599358
Toxic encephalopathy	16.55	15.18	51	140233	11389	79592715
Infusion site hypoaesthesia	16.39	15.18	5	140279	35	79604069
Kidney infection	16.38	15.18	9	140275	21842	79582262
Ventricular dysfunction	16.24	15.18	34	140250	5989	79598115
Vascular access site occlusion	16.23	15.18	6	140278	80	79604024
Gastroenteritis viral	16.18	15.18	12	140272	24819	79579285
Nephritis allergic	16.10	15.18	12	140272	718	79603386
Abdominal sepsis	16.09	15.18	19	140265	2043	79602061
Drug ineffective for unapproved indication	16.07	15.18	42	140242	51196	79552908
Neuronal neuropathy	16.03	15.18	3	140281	0	79604104
Myoclonus	16.01	15.18	15	140269	27645	79576459
Catheter site bruise	15.99	15.18	10	140274	448	79603656
Lethargy	15.98	15.18	81	140203	81211	79522893
Hemiparaesthesia	15.96	15.18	8	140276	232	79603872
Splenic abscess	15.91	15.18	11	140273	585	79603519
Glycosylated haemoglobin increased	15.85	15.18	7	140277	19253	79584851
Device malfunction	15.83	15.18	9	140275	21439	79582665
Haemoglobin abnormal	15.83	15.18	37	140247	7017	79597087
Therapy cessation	15.83	15.18	26	140258	37536	79566568
Depressed mood	15.78	15.18	39	140245	48441	79555663
Squamous cell carcinoma	15.78	15.18	4	140280	15618	79588486
Soft tissue necrosis	15.77	15.18	13	140271	902	79603202
Lymphadenopathy mediastinal	15.76	15.18	28	140256	4368	79599736
Cerebral vasoconstriction	15.75	15.18	16	140268	1454	79602650
Aortic intramural haematoma	15.74	15.18	7	140277	154	79603950
Mechanical ileus	15.72	15.18	13	140271	906	79603198
Coombs test positive	15.71	15.18	8	140276	240	79603864
Joint effusion	15.71	15.18	6	140278	18008	79586096
Ichthyosis	15.65	15.18	7	140277	156	79603948
Motion sickness	15.64	15.18	13	140271	912	79603192
Diffuse alveolar damage	15.64	15.18	25	140259	3579	79600525
Upper limb fracture	15.64	15.18	6	140278	17961	79586143
Pollakiuria	15.57	15.18	26	140258	37291	79566813
Systemic infection	15.55	15.18	45	140239	9707	79594397
Agitation	15.54	15.18	107	140177	99608	79504496
Aortic dissection	15.50	15.18	27	140257	4148	79599956
Lip dry	15.47	15.18	4	140280	15414	79588690
Vaginal cellulitis	15.41	15.18	6	140278	93	79604011
Aplasia	15.40	15.18	39	140245	7781	79596323
Red blood cell count decreased	15.25	15.18	51	140233	57462	79546642
Hip fracture	15.23	15.18	19	140265	30742	79573362
Deep vein thrombosis	15.21	15.18	298	139986	120621	79483483

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L01XA03	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Platinum compounds
FDA EXT	N0000175073	Platinum-containing Compounds
FDA EPC	N0000175413	Platinum-based Drug
MeSH PA	D000970	Antineoplastic Agents
CHEBI has role	CHEBI:25435	mutagens
CHEBI has role	CHEBI:35610	antineoplastic agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Metastasis from malignant tumor of colon	indication	314998002
Malignant tumor of stomach	indication	363349007	DOID:10534
Small intestine cancer	indication	363509000	DOID:10154
Lymph Node Positive Colorectal Carcinoma	indication
Malignant tumor of colon	off-label use	363406005	DOID:219
Malignant tumor of testis	off-label use	363449006	DOID:2998
Adenocarcinoma of pancreas	off-label use	700423003	DOID:4074
Fibrosis of lung	contraindication	51615001	DOID:3770
Interstitial pneumonia	contraindication	64667001
Kidney disease	contraindication	90708001	DOID:557
Liver function tests abnormal	contraindication	166603001
Disease of liver	contraindication	235856003	DOID:409
Pregnancy, function	contraindication	289908002
Peripheral nerve disease	contraindication	302226006
Breastfeeding (mother)	contraindication	413712001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4021355	VUID
N0000148774	NUI
D01790	KEGG_DRUG
4021355	VANDF
C0069717	UMLSCUI
CHEBI:31941	CHEBI
1PT	PDB_CHEM_ID
CHEMBL414804	ChEMBL_ID
D000077150	MESH_DESCRIPTOR_UI
DB00526	DRUGBANK_ID
7433	IUPHAR_LIGAND_ID
6012	INN_ID
04ZR38536J	UNII
9887053	PUBCHEM_CID
32592	RXNORM
165344	MMSL
16916	MMSL
d04811	MMSL
007166	NDDF
327032007	SNOMEDCT_US
395814003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-3985	INJECTION, SOLUTION, CONCENTRATE	50 mg	INTRAVENOUS	NDA	28 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-3985	INJECTION, SOLUTION, CONCENTRATE	50 mg	INTRAVENOUS	NDA	28 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-3986	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	NDA	28 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-3986	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	NDA	28 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0781-3315	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	29 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0781-3315	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	29 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0781-3317	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	29 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0781-3317	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	29 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0781-9315	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	28 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0781-9317	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	28 sections
OXALIPLATIN	HUMAN PRESCRIPTION DRUG LABEL	1	0955-1725	INJECTION, SOLUTION, CONCENTRATE	5 mg	INTRAVENOUS	NDA AUTHORIZED GENERIC	33 sections
OXALIPLATIN	HUMAN PRESCRIPTION DRUG LABEL	1	0955-1725	INJECTION, SOLUTION, CONCENTRATE	5 mg	INTRAVENOUS	NDA AUTHORIZED GENERIC	33 sections
OXALIPLATIN	HUMAN PRESCRIPTION DRUG LABEL	1	0955-1727	INJECTION, SOLUTION, CONCENTRATE	5 mg	INTRAVENOUS	NDA AUTHORIZED GENERIC	33 sections
OXALIPLATIN	HUMAN PRESCRIPTION DRUG LABEL	1	0955-1727	INJECTION, SOLUTION, CONCENTRATE	5 mg	INTRAVENOUS	NDA AUTHORIZED GENERIC	33 sections
OXALIPLATIN	HUMAN PRESCRIPTION DRUG LABEL	1	0955-1731	INJECTION, SOLUTION, CONCENTRATE	5 mg	INTRAVENOUS	NDA AUTHORIZED GENERIC	33 sections
OXALIPLATIN	HUMAN PRESCRIPTION DRUG LABEL	1	0955-1731	INJECTION, SOLUTION, CONCENTRATE	5 mg	INTRAVENOUS	NDA AUTHORIZED GENERIC	33 sections
OXALIPLATIN	HUMAN PRESCRIPTION DRUG LABEL	1	0955-1733	INJECTION, SOLUTION, CONCENTRATE	5 mg	INTRAVENOUS	NDA AUTHORIZED GENERIC	33 sections
OXALIPLATIN	HUMAN PRESCRIPTION DRUG LABEL	1	0955-1733	INJECTION, SOLUTION, CONCENTRATE	5 mg	INTRAVENOUS	NDA AUTHORIZED GENERIC	33 sections
oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	16714-727	INJECTION	5 mg	INTRAVENOUS	ANDA	27 sections
oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	16714-728	INJECTION	5 mg	INTRAVENOUS	ANDA	27 sections
oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	16729-332	INJECTION, SOLUTION, CONCENTRATE	5 mg	INTRAVENOUS	ANDA	30 sections
oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	25021-233	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	28 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	43066-014	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	28 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	43066-018	INJECTION, SOLUTION	5 mg	INTRAVENOUS	ANDA	28 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	45963-611	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	5 mg	INTRAVENOUS	ANDA	20 sections
Oxaliplatin	HUMAN PRESCRIPTION DRUG LABEL	1	45963-611	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	5 mg	INTRAVENOUS	ANDA	20 sections
Oxaliplatin	Human Prescription Drug Label	1	47335-046	INJECTION, SOLUTION, CONCENTRATE	50 mg	INTRAVENOUS	ANDA	27 sections
Oxaliplatin	Human Prescription Drug Label	1	47335-047	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	27 sections
Oxaliplatin	Human Prescription Drug Label	1	47335-176	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	50 mg	INTRAVENOUS	ANDA	28 sections
Oxaliplatin	Human Prescription Drug Label	1	47335-178	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	100 mg	INTRAVENOUS	ANDA	28 sections