oxaliplatin ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antineoplastic agents, platinum derivatives 4210 61825-94-3

Description:

MoleculeDescription

Synonyms:

  • oxaliplatin
  • oxalatoplatin
  • oxalatoplatinum
An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS.
  • Molecular weight: 397.29
  • Formula: C8H14N2O4Pt
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 6 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 8.13 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.50 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.13 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 58.92 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 9, 2002 FDA
March 18, 2005 PMDA Yakult Honsha

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuropathy peripheral 1132.01 17.02 909 58826 101984 56130348
Neutropenia 985.52 17.02 1015 58720 157152 56075180
Laryngospasm 983.73 17.02 279 59456 2605 56229727
Thrombocytopenia 734.21 17.02 810 58925 135414 56096918
Disease progression 718.33 17.02 710 59025 104463 56127869
Neurotoxicity 697.99 17.02 339 59396 15456 56216876
Diarrhoea 586.32 17.02 1738 57997 636769 55595563
Mucosal inflammation 499.25 17.02 392 59343 42418 56189914
Palmar-plantar erythrodysaesthesia syndrome 440.60 17.02 276 59459 20789 56211543
Paraesthesia 434.76 17.02 610 59125 129904 56102428
Vomiting 406.10 17.02 1303 58432 496925 55735407
Myelosuppression 330.95 17.02 215 59520 17240 56215092
Bone marrow failure 329.63 17.02 259 59476 28027 56204305
Dysarthria 322.77 17.02 295 59440 39255 56193077
Stridor 322.11 17.02 124 59611 3171 56229161
Peripheral sensory neuropathy 315.34 17.02 152 59583 6804 56225528
Dermatitis acneiform 308.86 17.02 130 59605 4214 56228118
Polyneuropathy 293.18 17.02 179 59556 12871 56219461
Drug ineffective 286.80 17.02 334 59401 918655 55313677
Throat tightness 284.70 17.02 216 59519 22191 56210141
Arthralgia 284.03 17.02 90 59645 501579 55730753
Bronchospasm 282.42 17.02 187 59548 15482 56216850
Arteriospasm coronary 265.51 17.02 111 59624 3536 56228796
Skin toxicity 264.61 17.02 115 59620 4038 56228294
Dysaesthesia pharynx 249.56 17.02 52 59683 97 56232235
Colorectal cancer metastatic 249.45 17.02 73 59662 768 56231564
Metastases to liver 243.62 17.02 194 59541 21392 56210940
Joint swelling 242.01 17.02 17 59718 289783 55942549
Nausea 241.95 17.02 1507 58228 762671 55469661
Febrile neutropenia 210.49 17.02 391 59344 105154 56127178
Haematotoxicity 206.45 17.02 122 59613 8261 56224071
Gastrointestinal toxicity 204.41 17.02 109 59626 6047 56226285
Pain 197.79 17.02 249 59486 662935 55569397
Arthropathy 193.00 17.02 4 59731 200271 56032061
Leukopenia 190.48 17.02 300 59435 70640 56161692
Gastrointestinal perforation 185.77 17.02 83 59652 3116 56229216
Malignant neoplasm progression 184.99 17.02 302 59433 73285 56159047
Headache 180.39 17.02 197 59538 558847 55673485
Swelling 179.03 17.02 22 59713 239749 55992583
Enteritis 177.24 17.02 106 59629 7337 56224995
Product dose omission issue 176.85 17.02 10 59725 204743 56027589
Sinusitis 175.88 17.02 8 59727 197573 56034759
Neutrophil count decreased 174.73 17.02 239 59496 49583 56182749
Posterior reversible encephalopathy syndrome 172.77 17.02 140 59595 15820 56216512
Systemic lupus erythematosus 168.17 17.02 5 59730 180073 56052259
Contraindicated product administered 167.60 17.02 7 59728 186279 56046053
Non-cirrhotic portal hypertension 163.34 17.02 38 59697 142 56232190
Portal hypertension 162.37 17.02 78 59657 3463 56228869
Erythema 156.41 17.02 440 59295 155499 56076833
Dyspnoea 156.21 17.02 1118 58617 591459 55640873
Nasopharyngitis 156.14 17.02 24 59711 220935 56011397
Weight increased 153.40 17.02 29 59706 229674 56002658
Pemphigus 152.00 17.02 3 59732 157209 56075123
Dehydration 146.59 17.02 435 59300 158390 56073942
Maternal exposure during pregnancy 142.43 17.02 17 59718 189536 56042796
Glossodynia 139.61 17.02 5 59730 152453 56079879
Anaphylactic shock 139.25 17.02 142 59593 21598 56210734
Abdominal discomfort 134.58 17.02 63 59672 277211 55955121
Therapeutic product effect decreased 132.90 17.02 13 59722 169439 56062893
Chills 132.08 17.02 318 59417 102286 56130046
Abdominal pain 129.02 17.02 580 59155 258225 55974107
Peripheral swelling 125.73 17.02 46 59689 234680 55997652
Wound 125.55 17.02 5 59730 138799 56093533
Venoocclusive liver disease 123.92 17.02 70 59665 4351 56227981
Ascites 122.50 17.02 174 59561 37370 56194962
Fall 120.67 17.02 121 59614 357389 55874943
Paronychia 119.59 17.02 71 59664 4847 56227485
Laryngeal oedema 117.11 17.02 72 59663 5238 56227094
Product use issue 116.95 17.02 27 59708 186014 56046318
Hyperammonaemia 114.12 17.02 69 59666 4871 56227461
Depression 111.52 17.02 27 59708 180090 56052242
Anaemia 109.82 17.02 567 59168 266944 55965388
Dysphonia 109.23 17.02 175 59560 41772 56190560
Splenomegaly 107.53 17.02 88 59647 10080 56222252
Insomnia 107.21 17.02 35 59700 191825 56040507
Immune thrombocytopenia 105.37 17.02 85 59650 9540 56222792
Dysaesthesia 104.23 17.02 61 59674 4055 56228277
Hypomagnesaemia 103.17 17.02 130 59605 24885 56207447
Asthma 102.19 17.02 4 59731 112766 56119566
Paraesthesia oral 101.04 17.02 99 59636 14350 56217982
Lower respiratory tract infection 100.96 17.02 5 59730 114789 56117543
Cardiotoxicity 99.91 17.02 75 59660 7575 56224757
Intestinal perforation 99.75 17.02 87 59648 10872 56221460
Drug intolerance 99.59 17.02 81 59654 264737 55967595
Asthenia 96.94 17.02 659 59076 342314 55890018
Speech disorder 95.68 17.02 155 59580 37338 56194994
Focal nodular hyperplasia 94.39 17.02 31 59704 490 56231842
Tongue oedema 92.83 17.02 56 59679 3936 56228396
Metastases to lung 92.79 17.02 86 59649 11632 56220700
Bronchitis 92.44 17.02 7 59728 112304 56120028
Therapy partial responder 92.18 17.02 72 59663 7713 56224619
Intestinal obstruction 90.30 17.02 129 59606 27842 56204490
Hypokalaemia 90.23 17.02 262 59473 94175 56138157
Pericarditis 89.06 17.02 7 59728 108916 56123416
Decreased appetite 87.36 17.02 461 59274 218770 56013562
Large intestine perforation 87.36 17.02 70 59665 7781 56224551
Anastomotic leak 86.30 17.02 28 59707 425 56231907
Dysphagia 84.77 17.02 234 59501 81713 56150619
Enterocolitis 84.76 17.02 66 59669 7038 56225294
Hepatic enzyme increased 82.99 17.02 39 59696 171345 56060987
Musculoskeletal stiffness 82.77 17.02 31 59704 155976 56076356
Neuromyotonia 82.51 17.02 18 59717 46 56232286
Stress cardiomyopathy 81.61 17.02 69 59666 8267 56224065
Flushing 80.41 17.02 208 59527 69892 56162440
Metastases to peritoneum 79.99 17.02 46 59689 2958 56229374
Influenza 78.22 17.02 6 59729 95255 56137077
Pain in extremity 77.97 17.02 122 59613 297309 55935023
Exposure during pregnancy 77.69 17.02 24 59711 136318 56096014
Hyperthermia 75.87 17.02 66 59669 8219 56224113
Stomatitis 75.15 17.02 290 59445 120520 56111812
Hyperhidrosis 74.95 17.02 245 59490 93843 56138489
Alopecia 74.45 17.02 123 59612 293335 55938997
Nodular regenerative hyperplasia 73.79 17.02 25 59710 437 56231895
Treatment failure 73.38 17.02 45 59690 170347 56061985
Contusion 72.47 17.02 23 59712 128407 56103925
Arthritis 72.43 17.02 10 59725 99842 56132490
Ileus 71.83 17.02 81 59654 13801 56218531
Injection site pain 71.60 17.02 18 59717 117100 56115232
Colon cancer 71.54 17.02 68 59667 9493 56222839
Condition aggravated 71.50 17.02 163 59572 344735 55887597
Laryngeal discomfort 71.29 17.02 22 59713 281 56232051
General physical health deterioration 70.09 17.02 361 59374 169649 56062683
Platelet count decreased 69.98 17.02 260 59475 106123 56126209
Oxygen saturation decreased 69.48 17.02 213 59522 78854 56153478
Neoplasm progression 69.29 17.02 123 59612 31893 56200439
Hyperammonaemic encephalopathy 67.82 17.02 37 59698 2148 56230184
Pyrexia 67.67 17.02 710 59025 418063 55814269
Hospitalisation 66.80 17.02 3 59732 74997 56157335
Haemolytic anaemia 65.19 17.02 65 59670 9620 56222712
Helicobacter infection 65.03 17.02 3 59732 73265 56159067
Drug hypersensitivity 62.92 17.02 123 59612 275082 55957250
Injection site erythema 60.53 17.02 6 59729 77442 56154890
Colon cancer metastatic 60.24 17.02 28 59707 1153 56231179
Interstitial lung disease 60.04 17.02 164 59571 56899 56175433
Duodenal ulcer perforation 60.01 17.02 3 59732 68339 56163993
Peritonitis 58.70 17.02 79 59656 16123 56216209
Adenocarcinoma of colon 58.08 17.02 35 59700 2455 56229877
Hypertensive crisis 57.95 17.02 73 59662 13963 56218369
Tumour perforation 57.82 17.02 15 59720 96 56232236
Anaphylactic reaction 57.60 17.02 165 59570 58830 56173502
Discomfort 57.55 17.02 40 59695 141721 56090611
Acute coronary syndrome 57.50 17.02 61 59674 9707 56222625
Feeling hot 57.50 17.02 133 59602 41654 56190678
Cardiac failure congestive 56.56 17.02 12 59723 87708 56144624
Drug abuse 56.24 17.02 4 59731 67606 56164726
Hypertension 56.08 17.02 447 59288 243831 55988501
Enterocutaneous fistula 56.00 17.02 27 59708 1208 56231124
Metastases to meninges 55.79 17.02 33 59702 2237 56230095
Chemical peritonitis 53.78 17.02 14 59721 91 56232241
Neutropenic colitis 52.49 17.02 34 59701 2709 56229623
Extravasation 52.21 17.02 31 59704 2116 56230216
Hydronephrosis 51.39 17.02 56 59679 9186 56223146
Injury 51.38 17.02 3 59732 59848 56172484
Tachycardia 50.90 17.02 235 59500 105641 56126691
Colitis 49.94 17.02 126 59609 41685 56190647
Disseminated intravascular coagulation 49.84 17.02 77 59658 17808 56214524
Suicide attempt 49.35 17.02 3 59732 57833 56174499
Suicidal ideation 49.25 17.02 3 59732 57739 56174593
Cholinergic syndrome 49.11 17.02 18 59717 400 56231932
Somnolence 48.78 17.02 61 59674 163352 56068980
Varices oesophageal 48.21 17.02 33 59702 2883 56229449
Blister 47.92 17.02 28 59707 108859 56123473
Upper respiratory tract infection 47.53 17.02 9 59726 71279 56161053
Diffuse large B-cell lymphoma recurrent 47.04 17.02 27 59708 1730 56230602
Dihydropyrimidine dehydrogenase deficiency 46.92 17.02 12 59723 72 56232260
Gastric varices haemorrhage 46.84 17.02 13 59722 111 56232221
Choking sensation 46.69 17.02 34 59701 3277 56229055
Proteinuria 46.68 17.02 74 59661 17496 56214836
Metastases to ovary 46.54 17.02 17 59718 374 56231958
Rectal perforation 46.45 17.02 17 59718 376 56231956
Diffuse large B-cell lymphoma refractory 46.11 17.02 23 59712 1109 56231223
Blood lactate dehydrogenase abnormal 45.97 17.02 15 59720 232 56232100
Mobility decreased 45.67 17.02 24 59711 98967 56133365
Cough 45.27 17.02 134 59601 259827 55972505
Stress 44.91 17.02 5 59730 58905 56173427
Evans syndrome 44.86 17.02 14 59721 186 56232146
Band sensation 44.85 17.02 20 59715 747 56231585
Sensation of foreign body 44.26 17.02 36 59699 4086 56228246
Mucosal toxicity 43.93 17.02 16 59719 349 56231983
Pneumonia 43.90 17.02 253 59482 406845 55825487
Laryngeal dyspnoea 43.89 17.02 13 59722 143 56232189
Suffocation feeling 43.67 17.02 23 59712 1243 56231089
Off label use 43.00 17.02 828 58907 555352 55676980
Intentional product misuse 42.97 17.02 3 59732 51501 56180831
Steatohepatitis 42.84 17.02 17 59718 472 56231860
Overdose 42.76 17.02 30 59705 105800 56126532
Cataract 42.71 17.02 3 59732 51244 56181088
Leukoencephalopathy 42.47 17.02 35 59700 4047 56228285
Hepatic failure 42.19 17.02 103 59632 33383 56198949
Pancytopenia 41.96 17.02 196 59539 88519 56143813
Injection site reaction 41.94 17.02 4 59731 53243 56179089
Drug interaction 41.90 17.02 101 59634 209654 56022678
Anxiety 41.85 17.02 89 59646 193083 56039249
Gait disturbance 41.78 17.02 68 59667 163253 56069079
Neutrophil count abnormal 41.29 17.02 29 59706 2641 56229691
Cold dysaesthesia 41.26 17.02 8 59727 8 56232324
Splenic artery thrombosis 41.14 17.02 10 59725 47 56232285
Carcinoembryonic antigen increased 41.10 17.02 24 59711 1588 56230744
White blood cell count decreased 40.91 17.02 251 59484 125739 56106593
Cytokine release syndrome 40.89 17.02 54 59681 10821 56221511
Osteoporosis 40.76 17.02 4 59731 52048 56180284
Factor VII deficiency 40.71 17.02 9 59726 25 56232307
Breast cancer 40.29 17.02 3 59732 48830 56183502
Migraine 40.10 17.02 21 59714 86776 56145556
Metastases to spleen 39.88 17.02 12 59723 140 56232192
Tremor 39.80 17.02 242 59493 120847 56111485
Acute polyneuropathy 39.15 17.02 13 59722 213 56232119
Infusion related hypersensitivity reaction 38.83 17.02 12 59723 154 56232178
Cystitis radiation 38.82 17.02 10 59725 62 56232270
Large intestinal obstruction 38.75 17.02 25 59710 1978 56230354
Type 2 diabetes mellitus 38.32 17.02 3 59732 46859 56185473
Pharyngeal dyskinesia 38.20 17.02 9 59726 36 56232296
Hypertrichosis 38.20 17.02 20 59715 1068 56231264
Multiple organ dysfunction syndrome 38.10 17.02 133 59602 52637 56179695
Oropharyngeal discomfort 37.73 17.02 34 59701 4434 56227898
Fatigue 37.68 17.02 600 59135 787952 55444380
Bladder tamponade 37.65 17.02 10 59725 71 56232261
Pharyngeal paraesthesia 37.52 17.02 23 59712 1664 56230668
Thrombocytopenic purpura 37.17 17.02 21 59714 1305 56231027
Cardiac ventricular thrombosis 37.12 17.02 16 59719 550 56231782
Short-bowel syndrome 36.96 17.02 15 59720 442 56231890
Chronic obstructive pulmonary disease 36.71 17.02 8 59727 57407 56174925
Folliculitis 36.52 17.02 7 59728 54972 56177360
Infection 36.45 17.02 101 59634 200105 56032227
Hypertransaminasaemia 36.21 17.02 34 59701 4673 56227659
Paralysis 35.75 17.02 46 59689 8986 56223346
Memory impairment 35.68 17.02 24 59711 86533 56145799
Muscle rigidity 35.59 17.02 50 59685 10621 56221711
Atypical haemolytic uraemic syndrome 35.38 17.02 16 59719 618 56231714
Formication 35.09 17.02 31 59704 3939 56228393
Ileal perforation 35.00 17.02 14 59721 397 56231935
COVID-19 34.91 17.02 18 59717 75040 56157292
Incorrect dose administered 34.26 17.02 7 59728 52540 56179792
Metastasis 33.86 17.02 33 59702 4751 56227581
ECG signs of myocardial ischaemia 33.75 17.02 9 59726 65 56232267
Injection site pruritus 33.42 17.02 3 59732 41928 56190404
Sleep disorder 33.34 17.02 15 59720 67648 56164684
Inappropriate schedule of product administration 33.21 17.02 24 59711 83363 56148969
Hypoalbuminaemia 32.91 17.02 48 59687 10551 56221781
Myalgia 32.81 17.02 56 59679 131969 56100363
Abortion spontaneous 32.64 17.02 4 59731 43749 56188583
Muscle spasms 32.36 17.02 253 59482 137118 56095214
Anastomotic fistula 32.34 17.02 7 59728 17 56232315
Respiratory distress 32.30 17.02 90 59645 31577 56200755
Female genital tract fistula 31.82 17.02 31 59704 4461 56227871
Type I hypersensitivity 31.70 17.02 24 59711 2454 56229878
Peripheral motor neuropathy 31.63 17.02 20 59715 1528 56230804
Tumour ulceration 31.56 17.02 10 59725 140 56232192
Ocular toxicity 31.47 17.02 15 59720 654 56231678
Gastric perforation 31.28 17.02 20 59715 1558 56230774
Haemolysis 31.17 17.02 36 59699 6292 56226040
Motion sickness 31.11 17.02 16 59719 823 56231509
Catheter site bruise 30.62 17.02 12 59723 322 56232010
Vascular pain 30.58 17.02 15 59720 697 56231635
Perforation 30.50 17.02 17 59718 1029 56231303
Nicotinic acid deficiency 30.35 17.02 8 59727 55 56232277
Tumour necrosis 29.98 17.02 15 59720 728 56231604
Hyperpyrexia 29.85 17.02 26 59709 3242 56229090
Rectal cancer 29.79 17.02 21 59714 1924 56230408
Metastases to lymph nodes 29.68 17.02 38 59697 7385 56224947
Dysgeusia 29.43 17.02 103 59632 40812 56191520
Blood pressure fluctuation 29.36 17.02 4 59731 40356 56191976
Paraphilia 29.25 17.02 5 59730 0 56232332
Rectal cancer recurrent 29.14 17.02 7 59728 31 56232301
Hemiparesis 29.12 17.02 68 59667 21422 56210910
Pulmonary embolism 29.04 17.02 204 59531 106920 56125412
Hemiparaesthesia 28.75 17.02 8 59727 69 56232263
Inflammation 28.67 17.02 19 59716 69052 56163280
Wrong technique in product usage process 28.50 17.02 13 59722 58155 56174177
Congestive cardiomyopathy 28.49 17.02 33 59702 5786 56226546
Hypophagia 28.40 17.02 81 59654 28795 56203537
Cyanosis 28.29 17.02 56 59679 15754 56216578
Anaphylactoid reaction 28.28 17.02 26 59709 3480 56228852
Subileus 28.06 17.02 24 59711 2920 56229412
Mucosal necrosis 27.96 17.02 7 59728 38 56232294
Trismus 27.95 17.02 26 59709 3532 56228800
Haemolytic uraemic syndrome 27.92 17.02 22 59713 2386 56229946
Tonic clonic movements 27.44 17.02 17 59718 1253 56231079
K-ras gene mutation 27.32 17.02 6 59729 16 56232316
Left ventricular failure 27.30 17.02 30 59705 4966 56227366
Inferior vena cava stenosis 27.05 17.02 6 59729 17 56232315
Feeling abnormal 26.92 17.02 64 59671 133538 56098794
Medical device site extravasation 26.90 17.02 5 59730 3 56232329
Administration site extravasation 26.77 17.02 14 59721 746 56231586
White blood cell count abnormal 26.62 17.02 32 59703 5835 56226497
Hepatic function abnormal 26.61 17.02 89 59646 34469 56197863
Cardiospasm 26.55 17.02 6 59729 19 56232313
Lip oedema 26.52 17.02 25 59710 3453 56228879
Skin fissures 26.37 17.02 41 59694 9532 56222800
Impaired healing 26.34 17.02 32 59703 86809 56145523
Herpes zoster 26.31 17.02 25 59710 75864 56156468
Palmar erythema 25.93 17.02 18 59717 1609 56230723
Cholangitis 25.81 17.02 29 59706 4920 56227412
Schistosomiasis 25.79 17.02 5 59730 5 56232327
Haematemesis 25.73 17.02 78 59657 28680 56203652
Autoimmune haemolytic anaemia 25.70 17.02 27 59708 4249 56228083
Catabolic state 25.52 17.02 7 59728 57 56232275
Thrombotic microangiopathy 25.50 17.02 40 59695 9371 56222961
Hypotension 25.44 17.02 390 59345 250118 55982214
Confusional state 25.37 17.02 124 59611 208031 56024301
Rhabdomyolysis 25.32 17.02 6 59729 40652 56191680
Aortic intramural haematoma 25.10 17.02 7 59728 61 56232271
Influenza like illness 25.01 17.02 17 59718 60971 56171361
Hepatocellular injury 24.75 17.02 73 59662 26441 56205891
Small intestinal obstruction 24.75 17.02 55 59680 16770 56215562
Adverse event 24.70 17.02 14 59721 55362 56176970
Loss of personal independence in daily activities 24.66 17.02 30 59705 81339 56150993
Gastrointestinal anastomotic leak 24.64 17.02 9 59726 198 56232134
Urinary tract infection 24.54 17.02 152 59583 240361 55991971
Chest discomfort 24.35 17.02 184 59551 98673 56133659
Ileus paralytic 24.34 17.02 26 59709 4169 56228163
Monoparesis 24.29 17.02 17 59718 1539 56230793
Treatment noncompliance 24.29 17.02 3 59732 32620 56199712
Metastases to diaphragm 24.22 17.02 6 59729 31 56232301
Gastrointestinal stoma complication 24.11 17.02 17 59718 1558 56230774
Sedation 24.10 17.02 4 59731 34850 56197482
Biliary tract infection 24.09 17.02 12 59723 577 56231755
Metastases to bone marrow 24.08 17.02 10 59725 313 56232019
Soft tissue necrosis 23.99 17.02 11 59724 439 56231893
Productive cough 23.98 17.02 15 59720 56217 56176115
Type II hypersensitivity 23.77 17.02 5 59730 10 56232322
Granulocyte count decreased 23.75 17.02 14 59721 943 56231389
Tachypnoea 23.33 17.02 51 59684 15379 56216953
Myopathy toxic 23.26 17.02 11 59724 471 56231861
Adverse drug reaction 23.12 17.02 21 59714 65111 56167221
Renal tubular disorder 23.02 17.02 20 59715 2486 56229846
Hypocapnia 22.93 17.02 10 59725 354 56231978
Nasal congestion 22.73 17.02 16 59719 56354 56175978
Portal shunt 22.59 17.02 5 59730 14 56232318
Implant site dehiscence 22.59 17.02 5 59730 14 56232318
Disease recurrence 22.57 17.02 66 59669 23794 56208538
Cardiogenic shock 22.49 17.02 52 59683 16273 56216059
Oesophageal varices haemorrhage 22.41 17.02 14 59721 1047 56231285
Balance disorder 22.36 17.02 29 59706 76491 56155841
Colitis ischaemic 22.33 17.02 39 59696 9981 56222351
Septic shock 22.18 17.02 125 59610 60710 56171622
Subacute cutaneous lupus erythematosus 22.09 17.02 19 59716 2330 56230002
Rhinorrhoea 21.95 17.02 17 59718 57020 56175312
Retching 21.93 17.02 46 59689 13484 56218848
Skin reaction 21.86 17.02 45 59690 13018 56219314
Blood phosphorus decreased 21.84 17.02 24 59711 3973 56228359
Emotional distress 21.53 17.02 3 59732 29760 56202572
Heart rate decreased 21.47 17.02 8 59727 40419 56191913
Dizziness 21.45 17.02 276 59459 375864 55856468
Blood glucose increased 21.43 17.02 29 59706 75122 56157210
Diabetes mellitus 21.23 17.02 15 59720 52720 56179612
Lacrimation disorder 21.16 17.02 4 59731 3 56232329
Hyperventilation 21.16 17.02 28 59707 5620 56226712
Hypoaesthesia oral 21.07 17.02 41 59694 11390 56220942
Gastrooesophageal reflux disease 20.97 17.02 35 59700 83222 56149110
Eyelid ptosis 20.94 17.02 30 59705 6489 56225843
Dry eye 20.85 17.02 6 59729 35710 56196622
Hepatic encephalopathy 20.79 17.02 38 59697 10072 56222260
Respiratory failure 20.70 17.02 172 59563 94890 56137442
Respiratory fatigue 20.68 17.02 7 59728 122 56232210
Post embolisation syndrome 20.63 17.02 4 59731 4 56232328
Dyslalia 20.58 17.02 10 59725 455 56231877
Coronary artery disease 20.29 17.02 4 59731 30792 56201540
Encapsulating peritoneal sclerosis 20.21 17.02 9 59726 335 56231997
Portal vein dilatation 20.15 17.02 5 59730 26 56232306
Pelvic fluid collection 20.08 17.02 12 59723 829 56231503
Toxic encephalopathy 20.07 17.02 28 59707 5910 56226422
Jaw operation 20.03 17.02 12 59723 833 56231499
Reticulocytosis 19.93 17.02 7 59728 137 56232195
Xerosis 19.86 17.02 11 59724 658 56231674
Drug reaction with eosinophilia and systemic symptoms 19.83 17.02 4 59731 30300 56202032
Road traffic accident 19.77 17.02 3 59732 27924 56204408
Encephalopathy 19.69 17.02 82 59653 35243 56197089
Subclavian vein thrombosis 19.67 17.02 16 59719 1816 56230516
Colorectal cancer 19.45 17.02 21 59714 3408 56228924
Bursitis 19.44 17.02 3 59732 27579 56204753
Oral dysaesthesia 19.42 17.02 6 59729 77 56232255
Viral infection 19.34 17.02 5 59730 31941 56200391
Hepatic vein stenosis 19.14 17.02 5 59730 33 56232299
Sputum abnormal 19.13 17.02 10 59725 532 56231800
Hyperlipasaemia 19.08 17.02 10 59725 535 56231797
Temperature intolerance 18.84 17.02 32 59703 8008 56224324
Red cell fragmentation syndrome 18.77 17.02 5 59730 36 56232296
Peripheral nerve injury 18.70 17.02 9 59726 401 56231931
Colorectal cancer recurrent 18.69 17.02 4 59731 9 56232323
Rectal cancer metastatic 18.67 17.02 8 59727 271 56232061
Unevaluable event 18.63 17.02 14 59721 47673 56184659
Stoma site haemorrhage 18.41 17.02 12 59723 966 56231366
Full blood count abnormal 18.38 17.02 3 59732 26459 56205873
Hypervolaemia 18.37 17.02 3 59732 26455 56205877
Tongue discomfort 18.34 17.02 16 59719 2000 56230332
Trichomegaly 18.20 17.02 5 59730 41 56232291
Pigmentation disorder 18.19 17.02 22 59713 4037 56228295
Embolism 18.18 17.02 30 59705 7334 56224998
Diaphragmatic paralysis 18.05 17.02 10 59725 598 56231734
Hereditary motor and sensory neuropathy 18.03 17.02 6 59729 99 56232233
Hyperbilirubinaemia 18.01 17.02 36 59699 10199 56222133
Aortic thrombosis 17.98 17.02 12 59723 1005 56231327
Aortitis 17.89 17.02 12 59723 1014 56231318
Endometrial dysplasia 17.87 17.02 4 59731 12 56232320
Gastrointestinal inflammation 17.61 17.02 24 59711 4954 56227378
Appendicitis noninfective 17.55 17.02 3 59732 0 56232332
Multiple sclerosis 17.52 17.02 4 59731 27798 56204534
Cold sweat 17.50 17.02 37 59698 10906 56221426
Femoral artery embolism 17.49 17.02 5 59730 48 56232284
Duodenal ulcer 17.46 17.02 29 59706 7126 56225206
Protein urine 17.45 17.02 10 59725 639 56231693
Femur fracture 17.43 17.02 10 59725 39285 56193047
Aortic dissection 17.40 17.02 15 59720 1844 56230488
Acute respiratory distress syndrome 17.35 17.02 57 59678 21869 56210463
Pulmonary artery thrombosis 17.30 17.02 10 59725 649 56231683
Hallucination 17.26 17.02 16 59719 49133 56183199
Cognitive disorder 17.25 17.02 16 59719 49117 56183215
Metastatic neoplasm 17.19 17.02 21 59714 3892 56228440
Gastrointestinal stoma output increased 17.04 17.02 7 59728 213 56232119

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuropathy peripheral 1344.16 15.73 1295 81530 74354 31540165
Disease progression 790.83 15.73 1073 81752 89391 31525128
Neurotoxicity 675.37 15.73 458 82367 15768 31598751
Diarrhoea 645.14 15.73 2198 80627 350211 31264308
Neutropenia 628.43 15.73 1229 81596 139135 31475384
Dermatitis acneiform 574.26 15.73 287 82538 5480 31609039
Palmar-plantar erythrodysaesthesia syndrome 569.24 15.73 405 82420 15078 31599441
Skin toxicity 554.57 15.73 253 82572 3906 31610613
Arteriospasm coronary 479.48 15.73 205 82620 2686 31611833
Thrombocytopenia 461.50 15.73 1096 81729 141651 31472868
Metastases to liver 404.61 15.73 305 82520 12422 31602097
Paronychia 386.20 15.73 182 82643 3036 31611483
Vomiting 333.99 15.73 1310 81515 222663 31391856
Erythema 332.47 15.73 682 82143 79723 31534796
Interstitial lung disease 307.70 15.73 565 82260 60838 31553681
Peripheral sensory neuropathy 305.74 15.73 196 82629 6119 31608400
Polyneuropathy 303.06 15.73 260 82565 12762 31601757
Paraesthesia 286.05 15.73 520 82305 55551 31558968
Myelosuppression 278.34 15.73 263 82562 14657 31599862
Nausea 272.89 15.73 1548 81277 306399 31308120
Venoocclusive liver disease 263.40 15.73 190 82635 7222 31607297
Chills 259.46 15.73 588 82237 73562 31540957
Mucosal inflammation 255.10 15.73 378 82447 34049 31580470
Portal hypertension 248.44 15.73 142 82683 3583 31610936
Haematotoxicity 237.87 15.73 176 82649 6961 31607558
Product dose omission issue 236.52 15.73 9 82816 105577 31508942
Gastrointestinal perforation 235.67 15.73 136 82689 3496 31611023
Hypersensitivity 229.25 15.73 472 82353 55271 31559248
Bone marrow failure 228.62 15.73 322 82503 27686 31586833
Completed suicide 223.33 15.73 3 82822 91511 31523008
Colorectal cancer metastatic 218.53 15.73 91 82734 1111 31613408
Drug ineffective 214.02 15.73 447 82378 395126 31219393
Arthralgia 208.57 15.73 68 82757 151356 31463163
Gastrointestinal toxicity 202.55 15.73 105 82720 2169 31612350
Stomatitis 191.26 15.73 358 82467 39080 31575439
Enteritis 190.60 15.73 154 82671 6945 31607574
Metastases to lung 189.54 15.73 165 82660 8257 31606262
Drug interaction 182.48 15.73 166 82659 208377 31406142
Laryngospasm 168.96 15.73 78 82747 1238 31613281
Fall 167.73 15.73 144 82681 185945 31428574
Flushing 159.36 15.73 284 82541 29844 31584675
Bronchospasm 156.55 15.73 160 82665 9812 31604707
Focal nodular hyperplasia 155.87 15.73 43 82782 120 31614399
Cardiotoxicity 154.26 15.73 118 82707 4909 31609610
Headache 150.35 15.73 155 82670 183497 31431022
Overdose 146.40 15.73 23 82802 84641 31529878
Pneumonia 142.76 15.73 428 82397 334884 31279635
Hypomagnesaemia 142.17 15.73 210 82615 18848 31595671
Abdominal pain 139.42 15.73 750 82075 145202 31469317
Decreased appetite 138.10 15.73 775 82050 152442 31462077
Hyperammonaemic encephalopathy 135.56 15.73 80 82745 2146 31612373
Carcinoembryonic antigen increased 127.79 15.73 52 82773 596 31613923
Hyperammonaemia 126.68 15.73 112 82713 5721 31608798
Dysaesthesia pharynx 122.55 15.73 29 82796 31 31614488
Skin reaction 121.41 15.73 100 82725 4634 31609885
Feeling hot 121.26 15.73 179 82646 16054 31598465
Proteinuria 119.72 15.73 181 82644 16582 31597937
Cardiac failure congestive 112.13 15.73 34 82791 79353 31535166
Oxygen saturation decreased 109.30 15.73 329 82496 48786 31565733
Therapy partial responder 107.95 15.73 108 82717 6454 31608065
Neutrophil count decreased 107.25 15.73 315 82510 46079 31568440
Anastomotic leak 106.36 15.73 45 82780 573 31613946
Dehydration 106.23 15.73 601 82224 118510 31496009
Pyrexia 106.23 15.73 1236 81589 302604 31311915
Leukopenia 105.64 15.73 362 82463 57466 31557053
Colon cancer metastatic 105.13 15.73 61 82764 1584 31612935
Infusion related reaction 104.21 15.73 319 82506 47736 31566783
Depression 103.56 15.73 54 82771 90761 31523758
Ascites 102.10 15.73 286 82539 40727 31573792
Intravascular haemolysis 102.09 15.73 39 82786 373 31614146
Insomnia 100.11 15.73 62 82763 94774 31519745
Enterocolitis 95.23 15.73 106 82719 7168 31607351
Hospitalisation 94.57 15.73 10 82815 49797 31564722
Intestinal obstruction 93.58 15.73 182 82643 20428 31594091
Varices oesophageal 92.43 15.73 74 82751 3292 31611227
Anxiety 90.03 15.73 64 82761 90969 31523550
Metastases to peritoneum 89.05 15.73 55 82770 1605 31612914
Joint swelling 89.05 15.73 16 82809 53415 31561104
Somnolence 86.99 15.73 79 82746 99366 31515153
Myalgia 86.52 15.73 47 82778 77211 31537308
Weight increased 86.47 15.73 55 82770 82892 31531627
Peripheral swelling 85.66 15.73 35 82790 67830 31546689
Anastomotic complication 84.04 15.73 33 82792 342 31614177
Tumour perforation 81.73 15.73 30 82795 254 31614265
Ileus 81.47 15.73 144 82681 15025 31599494
Anaphylactic shock 80.82 15.73 138 82687 14007 31600512
Aggression 80.72 15.73 4 82821 37287 31577232
Malignant neoplasm progression 80.11 15.73 413 82412 78585 31535934
Laryngeal discomfort 79.90 15.73 27 82798 174 31614345
Diffuse large B-cell lymphoma recurrent 78.71 15.73 64 82761 2911 31611608
Rhabdomyolysis 78.30 15.73 34 82791 63547 31550972
Toxic leukoencephalopathy 75.49 15.73 29 82796 282 31614237
Type I hypersensitivity 75.21 15.73 43 82782 1085 31613434
Influenza 74.45 15.73 13 82812 44312 31570207
Neoplasm progression 73.26 15.73 163 82662 20109 31594410
Foetal exposure during pregnancy 73.18 15.73 10 82815 40866 31573653
Inappropriate schedule of product administration 73.15 15.73 21 82804 50802 31563717
Stomal varices 72.31 15.73 19 82806 41 31614478
Confusional state 71.39 15.73 151 82674 133183 31481336
Injection site pain 71.06 15.73 5 82820 34629 31579890
Incorrect dose administered 70.99 15.73 6 82819 35746 31578773
Tumour necrosis 70.55 15.73 42 82783 1145 31613374
Asthma 70.48 15.73 13 82812 42598 31571921
Extravasation 69.64 15.73 48 82777 1694 31612825
Vascular pain 69.12 15.73 22 82803 114 31614405
Large intestine perforation 68.60 15.73 92 82733 7544 31606975
Portal shunt 68.05 15.73 17 82808 27 31614492
Dihydropyrimidine dehydrogenase deficiency 67.13 15.73 19 82806 60 31614459
Hallucination 67.11 15.73 19 82806 46391 31568128
Contusion 67.10 15.73 5 82820 33023 31581496
Peritonitis 66.73 15.73 133 82692 15194 31599325
Pneumatosis intestinalis 66.49 15.73 64 82761 3647 31610872
Pain in extremity 66.13 15.73 127 82698 116076 31498443
Death 65.48 15.73 615 82210 359954 31254565
Myocardial infarction 65.43 15.73 123 82702 113331 31501188
Disseminated intravascular coagulation 65.27 15.73 157 82668 20380 31594139
Non-cirrhotic portal hypertension 65.27 15.73 25 82800 241 31614278
Rectal perforation 65.01 15.73 29 82796 423 31614096
Blood glucose increased 64.34 15.73 40 82785 61043 31553476
Electrocardiogram QT prolonged 64.11 15.73 11 82814 37976 31576543
Hepatic atrophy 63.19 15.73 22 82803 157 31614362
Product use issue 62.85 15.73 35 82790 56724 31557795
Suicidal ideation 62.65 15.73 10 82815 36396 31578123
Hyperhidrosis 61.94 15.73 343 82482 67050 31547469
Adenocarcinoma of colon 61.49 15.73 58 82767 3222 31611297
Metastases to lymph nodes 60.75 15.73 65 82760 4203 31610316
Memory impairment 60.20 15.73 13 82812 38117 31576402
Electrocardiogram ST segment elevation 59.55 15.73 67 82758 4584 31609935
Tumour lysis syndrome 59.33 15.73 127 82698 15258 31599261
Paraesthesia oral 59.11 15.73 60 82765 3648 31610871
Hypertransaminasaemia 58.55 15.73 64 82761 4240 31610279
Coronary artery disease 57.77 15.73 24 82801 46063 31568456
Palmar erythema 56.72 15.73 23 82802 261 31614258
Necrotising fasciitis 56.65 15.73 57 82768 3429 31611090
Rash pustular 56.17 15.73 67 82758 4882 31609637
Cholinergic syndrome 56.08 15.73 27 82798 473 31614046
Dysphonia 55.61 15.73 148 82677 20443 31594076
Febrile neutropenia 55.21 15.73 523 82302 121326 31493193
Feeling abnormal 55.13 15.73 41 82784 56961 31557558
Hyperthermia 55.05 15.73 96 82729 9908 31604611
Agitation 54.97 15.73 37 82788 54132 31560387
Intestinal perforation 54.88 15.73 87 82738 8302 31606217
Splenomegaly 54.76 15.73 115 82710 13634 31600885
Cholangitis 53.87 15.73 84 82741 7902 31606617
Arthritis 53.28 15.73 5 82820 27380 31587139
Nodular regenerative hyperplasia 52.24 15.73 32 82793 920 31613599
Therapeutic product effect decreased 51.54 15.73 10 82815 31612 31582907
Hiccups 50.95 15.73 89 82736 9198 31605321
Administration site extravasation 50.41 15.73 26 82799 531 31613988
Temperature intolerance 49.95 15.73 50 82775 2989 31611530
Nasopharyngitis 49.82 15.73 55 82770 63190 31551329
Pain 49.43 15.73 286 82539 186473 31428046
Rectal cancer 49.27 15.73 43 82782 2158 31612361
Toxicity to various agents 49.07 15.73 276 82549 181211 31433308
Pulmonary embolism 48.89 15.73 373 82452 81273 31533246
Rectal cancer metastatic 48.78 15.73 20 82805 234 31614285
Drug reaction with eosinophilia and systemic symptoms 47.87 15.73 10 82815 30008 31584511
Irritability 47.85 15.73 3 82822 22886 31591633
Colon cancer 47.85 15.73 83 82742 8530 31605989
Stoma site haemorrhage 47.68 15.73 28 82797 744 31613775
Gastrointestinal anastomotic leak 47.60 15.73 22 82803 350 31614169
General physical health deterioration 47.52 15.73 479 82346 112956 31501563
Recall phenomenon 47.25 15.73 25 82800 539 31613980
Asthenia 47.23 15.73 837 81988 223918 31390601
Cellulitis 47.13 15.73 34 82791 47984 31566535
Unevaluable event 47.11 15.73 11 82814 30564 31583955
Drug dependence 47.08 15.73 3 82822 22576 31591943
Chronic obstructive pulmonary disease 46.98 15.73 30 82795 45136 31569383
Treatment noncompliance 46.65 15.73 6 82819 25678 31588841
Malignant ascites 45.72 15.73 22 82803 385 31614134
Transdifferentiation of neoplasm 45.42 15.73 14 82811 64 31614455
Mucosal toxicity 45.33 15.73 19 82806 236 31614283
Septic shock 44.03 15.73 310 82515 65848 31548671
Musculoskeletal stiffness 43.60 15.73 27 82798 41298 31573221
Prinzmetal angina 43.52 15.73 28 82797 879 31613640
Hypokalaemia 42.93 15.73 263 82562 53311 31561208
Dizziness 42.62 15.73 325 82500 198822 31415697
Splenorenal shunt 42.59 15.73 10 82815 10 31614509
Periportal sinus dilatation 42.10 15.73 11 82814 23 31614496
Neutropenic sepsis 41.90 15.73 97 82728 12282 31602237
Sinusitis 41.53 15.73 22 82803 36674 31577845
Throat tightness 41.43 15.73 73 82752 7596 31606923
Condition aggravated 41.35 15.73 255 82570 163754 31450765
Perforation 41.30 15.73 17 82808 201 31614318
Drug level increased 41.16 15.73 3 82822 20183 31594336
Immune thrombocytopenia 40.97 15.73 77 82748 8421 31606098
Evans syndrome 40.76 15.73 18 82807 256 31614263
Abnormal behaviour 39.98 15.73 7 82818 23821 31590698
Wound dehiscence 39.82 15.73 45 82780 3093 31611426
Cyanosis 39.77 15.73 92 82733 11643 31602876
Blood pressure fluctuation 39.67 15.73 6 82819 22730 31591789
Small intestinal obstruction 39.63 15.73 100 82725 13372 31601147
Noninfective epididymitis 39.60 15.73 8 82817 0 31614519
Oxygen saturation normal 39.60 15.73 8 82817 0 31614519
Influenza like illness 39.49 15.73 9 82816 25428 31589091
Diabetes mellitus 39.38 15.73 32 82793 42524 31571995
Intestinal ischaemia 39.28 15.73 68 82757 6977 31607542
Anastomotic fistula 39.26 15.73 13 82812 78 31614441
Enterovesical fistula 39.14 15.73 24 82801 691 31613828
Acute coronary syndrome 38.75 15.73 96 82729 12693 31601826
Psychotic disorder 38.63 15.73 6 82819 22287 31592232
Colorectal cancer 38.60 15.73 55 82770 4774 31609745
Chronic kidney disease 38.44 15.73 26 82799 37949 31576570
Off label use 38.35 15.73 1182 81643 346092 31268427
Cardiac disorder 38.17 15.73 28 82797 39186 31575333
Subileus 38.15 15.73 43 82782 2947 31611572
Large intestinal obstruction 37.82 15.73 31 82794 1426 31613093
Wrong technique in product usage process 37.72 15.73 20 82805 33323 31581196
Prostate cancer 37.72 15.73 26 82799 37575 31576944
Hypercreatinaemia 37.65 15.73 15 82810 162 31614357
Seizure 37.61 15.73 134 82691 99634 31514885
Blood pressure immeasurable 37.51 15.73 25 82800 834 31613685
Abdominal discomfort 37.25 15.73 48 82777 51519 31563000
Nicotinic acid deficiency 37.19 15.73 13 82812 94 31614425
Dysaesthesia 36.94 15.73 36 82789 2083 31612436
COVID-19 36.61 15.73 54 82771 54767 31559752
Fluid retention 36.14 15.73 10 82815 24792 31589727
International normalised ratio increased 35.97 15.73 39 82786 45184 31569335
Bronchitis 35.96 15.73 29 82796 38688 31575831
Premature baby 35.95 15.73 3 82822 18063 31596456
Cytomegalovirus infection 35.93 15.73 10 82815 24697 31589822
Tumour marker increased 35.79 15.73 21 82804 557 31613962
Gastric perforation 35.48 15.73 37 82788 2322 31612197
Type II hypersensitivity 35.47 15.73 10 82815 31 31614488
Hypertensive crisis 35.22 15.73 71 82754 8176 31606343
Pseudocirrhosis 35.05 15.73 9 82816 17 31614502
Herpes zoster 35.02 15.73 20 82805 31973 31582546
Contraindicated product administered 35.00 15.73 5 82820 19767 31594752
Liver function test abnormal 34.80 15.73 17 82808 29675 31584844
Hepatic infarction 34.77 15.73 15 82810 201 31614318
Blood creatine phosphokinase increased 34.74 15.73 35 82790 41939 31572580
Anaphylactic reaction 34.56 15.73 161 82664 29392 31585127
Hypoglycaemia 34.20 15.73 50 82775 50896 31563623
Acute abdomen 34.05 15.73 32 82793 1769 31612750
Stridor 33.85 15.73 36 82789 2311 31612208
Amaurosis fugax 33.54 15.73 20 82805 547 31613972
Portal venous gas 33.37 15.73 17 82808 338 31614181
Metastasis 33.07 15.73 44 82781 3580 31610939
Folliculitis 32.80 15.73 47 82778 4101 31610418
Portal vein thrombosis 32.65 15.73 43 82782 3464 31611055
Carbohydrate antigen 19-9 increased 32.36 15.73 14 82811 189 31614330
Performance status decreased 32.23 15.73 45 82780 3833 31610686
Cerebrovascular accident 31.82 15.73 104 82721 79380 31535139
Pelvic abscess 31.69 15.73 23 82802 882 31613637
Device related infection 31.46 15.73 104 82721 16195 31598324
Hypervolaemia 31.42 15.73 5 82820 18246 31596273
Haematoma 31.18 15.73 12 82813 24127 31590392
Dyspnoea 31.00 15.73 1142 81683 342337 31272182
Ocular toxicity 30.91 15.73 14 82811 212 31614307
Lymphangiosis carcinomatosa 30.58 15.73 22 82803 832 31613687
Leukoencephalopathy 30.54 15.73 44 82781 3858 31610661
Hypoalbuminaemia 30.52 15.73 80 82745 10948 31603571
Delirium 30.49 15.73 38 82787 41383 31573136
Hypovolaemic shock 30.47 15.73 58 82767 6404 31608115
Encapsulating peritoneal sclerosis 30.26 15.73 19 82806 571 31613948
Right ventricular ejection fraction decreased 30.16 15.73 9 82816 36 31614483
Pulmonary toxicity 30.11 15.73 52 82773 5325 31609194
Biliary fistula 29.77 15.73 9 82816 38 31614481
Oesophageal haemorrhage 29.63 15.73 25 82800 1198 31613321
ECG signs of myocardial ischaemia 29.56 15.73 13 82812 183 31614336
Accidental overdose 29.49 15.73 6 82819 18344 31596175
Hepatectomy 29.39 15.73 10 82815 66 31614453
Sciatic nerve palsy 29.22 15.73 9 82816 41 31614478
Localised infection 29.13 15.73 3 82822 15262 31599257
Perforation bile duct 29.08 15.73 8 82817 22 31614497
Blood alkaline phosphatase abnormal 28.93 15.73 16 82809 378 31614141
Sedation 28.87 15.73 7 82818 18958 31595561
Hyperkalaemia 28.77 15.73 80 82745 64271 31550248
Haemorrhage intracranial 28.71 15.73 3 82822 15085 31599434
Failure to anastomose 28.40 15.73 13 82812 202 31614317
Medication error 28.30 15.73 12 82813 22760 31591759
Nasal congestion 28.27 15.73 9 82816 20372 31594147
Blood cholesterol increased 28.26 15.73 5 82820 16888 31597631
Blood pressure systolic increased 28.09 15.73 8 82817 19462 31595057
Oesophageal varices haemorrhage 28.08 15.73 36 82789 2824 31611695
Haemolytic anaemia 28.07 15.73 72 82753 9724 31604795
Anaphylactoid reaction 28.06 15.73 31 82794 2078 31612441
Hyperaemia 27.99 15.73 23 82802 1062 31613457
Swelling 27.78 15.73 34 82791 37324 31577195
Head injury 27.72 15.73 5 82820 16653 31597866
Haemoglobinuria 27.67 15.73 18 82807 576 31613943
Mobility decreased 27.54 15.73 19 82806 27450 31587069
Alopecia 27.40 15.73 117 82708 20578 31593941
Upper respiratory tract infection 27.37 15.73 22 82803 29400 31585119
Muscular weakness 27.34 15.73 84 82741 65364 31549155
Hyperbilirubinaemia 27.34 15.73 97 82728 15653 31598866
Anal sphincter atony 27.31 15.73 10 82815 84 31614435
Small intestinal perforation 27.26 15.73 30 82795 2002 31612517
Necrotising oesophagitis 27.08 15.73 17 82808 511 31614008
Full blood count abnormal 27.00 15.73 5 82820 16342 31598177
Brain teratoma 27.00 15.73 7 82818 14 31614505
Emotional distress 26.94 15.73 3 82822 14353 31600166
Cachexia 26.75 15.73 56 82769 6623 31607896
Acute respiratory distress syndrome 26.74 15.73 131 82694 24409 31590110
Pulmonary fibrosis 26.72 15.73 100 82725 16560 31597959
Vocal cord paralysis 26.42 15.73 21 82804 924 31613595
Erectile dysfunction 25.79 15.73 9 82816 19226 31595293
Circulatory collapse 25.66 15.73 111 82714 19633 31594886
Productive cough 25.50 15.73 30 82795 33510 31581009
Skin fissures 25.37 15.73 43 82782 4337 31610182
Basal cell carcinoma 25.26 15.73 8 82817 18171 31596348
Osteomyelitis 25.24 15.73 4 82821 14639 31599880
Subdural haematoma 25.23 15.73 9 82816 18962 31595557
Pruritus 25.10 15.73 463 82362 124704 31489815
Road traffic accident 25.02 15.73 6 82819 16375 31598144
Hot flush 24.97 15.73 96 82729 16100 31598419
Biliary tract infection 24.96 15.73 17 82808 588 31613931
Gait disturbance 24.81 15.73 111 82714 77384 31537135
Toxic epidermal necrolysis 24.73 15.73 10 82815 19514 31595005
Embolism 24.73 15.73 57 82768 7196 31607323
Ileal perforation 24.67 15.73 18 82807 696 31613823
Adverse drug reaction 24.52 15.73 18 82807 25183 31589336
Renal disorder 24.18 15.73 16 82809 23629 31590890
Aortitis 24.14 15.73 14 82811 363 31614156
Koebner phenomenon 23.88 15.73 8 82817 50 31614469
Peripheral sensorimotor neuropathy 23.85 15.73 24 82801 1444 31613075
Oesophagitis 23.76 15.73 79 82746 12337 31602182
Perihepatic abscess 23.66 15.73 9 82816 85 31614434
Cardiac ventricular disorder 23.63 15.73 12 82813 237 31614282
Pulmonary artery thrombosis 23.63 15.73 17 82808 643 31613876
Nephrolithiasis 23.54 15.73 22 82803 27317 31587202
Eosinophilia 23.42 15.73 16 82809 23237 31591282
Laryngeal oedema 23.33 15.73 35 82790 3182 31611337
Pulmonary oedema 23.28 15.73 51 82774 44451 31570068
Adenocarcinoma 23.27 15.73 26 82799 1765 31612754
Throat irritation 23.20 15.73 65 82760 9249 31605270
Fistula of small intestine 22.74 15.73 14 82811 406 31614113
Cold sweat 22.68 15.73 64 82761 9145 31605374
Blood creatinine increased 22.67 15.73 138 82687 88940 31525579
Xerosis 22.36 15.73 15 82810 506 31614013
Interventricular septum rupture 22.22 15.73 6 82819 15 31614504
Hepatic failure 22.19 15.73 154 82671 32548 31581971
Cerebral vasoconstriction 22.19 15.73 11 82814 206 31614313
Onycholysis 22.15 15.73 16 82809 609 31613910
Muscle contractions involuntary 22.12 15.73 25 82800 1719 31612800
Liver abscess 22.09 15.73 36 82789 3515 31611004
Papilloedema 22.03 15.73 30 82795 2496 31612023
Oropharyngeal pain 22.02 15.73 30 82795 31453 31583066
Intestinal dilatation 21.97 15.73 20 82805 1061 31613458
Diffuse large B-cell lymphoma refractory 21.94 15.73 20 82805 1063 31613456
Gout 21.92 15.73 10 82815 18164 31596355
Cataract 21.90 15.73 18 82807 23789 31590730
Product prescribing error 21.90 15.73 12 82813 19630 31594889
Fingerprint loss 21.88 15.73 7 82818 37 31614482
Metastases to muscle 21.86 15.73 11 82814 213 31614306
Labelled drug-drug interaction medication error 21.79 15.73 4 82821 13159 31601360
Sleep disorder 21.76 15.73 22 82803 26326 31588193
Metastases to retroperitoneum 21.72 15.73 11 82814 216 31614303
Astringent therapy 21.68 15.73 6 82819 17 31614502
Hyperpyrexia 21.67 15.73 29 82796 2372 31612147
Pachymeningitis 21.67 15.73 9 82816 109 31614410
Gastric dilatation 21.65 15.73 16 82809 631 31613888
Wheezing 21.62 15.73 38 82787 35948 31578571
Neck pain 21.47 15.73 17 82808 22893 31591626
Rectosigmoid cancer 21.47 15.73 10 82815 162 31614357
Oesophagobronchial fistula 21.47 15.73 10 82815 162 31614357
Hyperfibrinolysis 21.19 15.73 6 82819 19 31614500
Obstruction gastric 21.13 15.73 18 82807 874 31613645
Tachycardia 20.92 15.73 297 82528 75910 31538609
Colon cancer recurrent 20.90 15.73 9 82816 120 31614399
Monocytopenia 20.90 15.73 8 82817 77 31614442
Portal vein dilatation 20.82 15.73 5 82820 6 31614513
Injection site erythema 20.75 15.73 6 82819 14456 31600063
Induration 20.71 15.73 18 82807 898 31613621
Nephrotic syndrome 20.62 15.73 52 82773 6951 31607568
Gene mutation 20.51 15.73 20 82805 1158 31613361
Haemoglobin abnormal 20.41 15.73 34 82791 3381 31611138
Oedema peripheral 20.39 15.73 186 82639 109653 31504866
Conjunctivitis 20.33 15.73 59 82766 8564 31605955
Aortic thrombosis 20.33 15.73 16 82809 694 31613825
Feeling cold 20.29 15.73 63 82762 9491 31605028
Laboratory test abnormal 20.25 15.73 12 82813 18802 31595717
Acral peeling skin syndrome 20.22 15.73 7 82818 49 31614470
Jaundice 20.18 15.73 142 82683 30145 31584374
Sarcoidosis 20.15 15.73 30 82795 2709 31611810
Trismus 20.12 15.73 28 82797 2377 31612142
Full blood count decreased 20.11 15.73 9 82816 16531 31597988
Wound infection 20.03 15.73 49 82776 6426 31608093
Catheter site extravasation 20.03 15.73 8 82817 87 31614432
Allodynia 20.03 15.73 15 82810 604 31613915
Mucocutaneous rash 19.91 15.73 6 82819 25 31614494
Pulmonary hypertension 19.91 15.73 14 82811 20027 31594492
Pelvic fluid collection 19.89 15.73 9 82816 136 31614383
Thrombotic thrombocytopenic purpura 19.82 15.73 33 82792 3280 31611239
Pneumonitis chemical 19.71 15.73 9 82816 139 31614380
Lower respiratory tract infection 19.65 15.73 27 82798 28210 31586309
Drug intolerance 19.52 15.73 70 82755 51963 31562556
Respiratory arrest 19.41 15.73 24 82801 26233 31588286
Diffuse large B-cell lymphoma 19.31 15.73 58 82767 8583 31605936
Hand-foot-genital syndrome 19.28 15.73 5 82820 10 31614509
Ischiorectal hernia 19.28 15.73 5 82820 10 31614509
Malaise 19.15 15.73 576 82249 167935 31446584
Hypersplenism 19.13 15.73 12 82813 360 31614159
Peritoneal haematoma 19.10 15.73 7 82818 59 31614460
Perineal disorder 18.89 15.73 7 82818 61 31614458
Angioedema 18.87 15.73 37 82788 33581 31580938
Cholestasis 18.76 15.73 121 82704 24954 31589565
Peritoneal lesion 18.76 15.73 8 82817 104 31614415
Oropharyngeal spasm 18.73 15.73 9 82816 157 31614362
Heart rate decreased 18.71 15.73 28 82797 28238 31586281
Shock 18.65 15.73 112 82713 22533 31591986
Obstructive airways disorder 18.65 15.73 5 82820 12659 31601860
Underdose 18.52 15.73 5 82820 12602 31601917
Disease susceptibility 18.50 15.73 7 82818 65 31614454
Band sensation 18.49 15.73 8 82817 108 31614411
Peripheral ischaemia 18.45 15.73 42 82783 5258 31609261
Blood triglycerides increased 18.43 15.73 6 82819 13391 31601128
Blood pressure increased 18.42 15.73 127 82698 79506 31535013
Gastrointestinal stoma complication 18.39 15.73 19 82806 1179 31613340
Appendicitis noninfective 18.38 15.73 5 82820 13 31614506
Pulmonary infarction 18.29 15.73 19 82806 1187 31613332
Choking sensation 18.23 15.73 18 82807 1058 31613461
Gastrointestinal mucosal necrosis 18.08 15.73 9 82816 170 31614349
Nephritis allergic 18.01 15.73 12 82813 400 31614119
Balance disorder 17.88 15.73 45 82780 37377 31577142
Chemical peritonitis 17.79 15.73 8 82817 119 31614400
Abdominal sepsis 17.76 15.73 17 82808 962 31613557
Metastases to spleen 17.72 15.73 12 82813 411 31614108
Blindness transient 17.66 15.73 24 82801 1993 31612526
Metastases to bone marrow 17.63 15.73 13 82812 511 31614008
Microangiopathic haemolytic anaemia 17.54 15.73 16 82809 851 31613668
Product administration error 17.46 15.73 9 82816 15238 31599281
Neurosarcoidosis 17.44 15.73 9 82816 184 31614335
Perineal ulceration 17.39 15.73 5 82820 17 31614502
Blood bilirubin decreased 17.30 15.73 11 82814 338 31614181
Vascular injury 17.29 15.73 10 82815 258 31614261
Hypothyroidism 17.22 15.73 13 82812 17934 31596585
Acute motor-sensory axonal neuropathy 17.16 15.73 8 82817 130 31614389
Gastrointestinal necrosis 17.14 15.73 30 82795 3104 31611415
Hypersomnia 17.13 15.73 4 82821 11115 31603404
Peripheral motor neuropathy 17.10 15.73 22 82803 1732 31612787
Intrahepatic portal hepatic venous fistula 17.04 15.73 4 82821 4 31614515
Biliary cancer metastatic 17.04 15.73 4 82821 4 31614515
Peritoneal disorder 16.88 15.73 10 82815 270 31614249
Loss of personal independence in daily activities 16.88 15.73 30 82795 28258 31586261
Hypoaesthesia 16.87 15.73 222 82603 55800 31558719
Colon cancer stage III 16.81 15.73 9 82816 199 31614320
Oral dysaesthesia 16.77 15.73 7 82818 86 31614433
Duodenal stenosis 16.77 15.73 9 82816 200 31614319
VIth nerve disorder 16.76 15.73 5 82820 20 31614499
Axonal and demyelinating polyneuropathy 16.56 15.73 5 82820 21 31614498
Metastases to pelvis 16.56 15.73 10 82815 280 31614239
Proteus infection 16.44 15.73 16 82809 924 31613595
Blood glucose decreased 16.44 15.73 6 82819 12465 31602054
Fistula 16.34 15.73 42 82783 5679 31608840
Type III immune complex mediated reaction 16.34 15.73 10 82815 287 31614232
Pancreatitis 16.33 15.73 44 82781 35727 31578792
Bacterial colitis 16.33 15.73 6 82819 51 31614468
Hyperlipidaemia 16.25 15.73 7 82818 13153 31601366
Hypotension 16.18 15.73 671 82154 203947 31410572
Stevens-Johnson syndrome 16.14 15.73 13 82812 17359 31597160
Tunnel vision 16.13 15.73 12 82813 478 31614041
Vascular access site occlusion 16.03 15.73 6 82819 54 31614465
Rhinorrhoea 16.02 15.73 22 82803 22990 31591529
Hepatic cancer recurrent 16.00 15.73 10 82815 298 31614221
Faeces discoloured 15.99 15.73 8 82817 13778 31600741
Respiratory depression 15.98 15.73 9 82816 14501 31600018
Electromyogram abnormal 15.93 15.73 6 82819 55 31614464
Retroperitoneal abscess 15.89 15.73 8 82817 155 31614364
Ichthyosis 15.89 15.73 7 82818 99 31614420
Pancreatic carcinoma metastatic 15.87 15.73 28 82797 2916 31611603
Eczema impetiginous 15.86 15.73 5 82820 25 31614494
Radiation interaction 15.86 15.73 5 82820 25 31614494
Skin laceration 15.85 15.73 5 82820 11386 31603133
Platelet count decreased 15.80 15.73 389 82436 110046 31504473
Hyperthyroidism 15.79 15.73 3 82822 9628 31604891
Haematemesis 15.78 15.73 118 82707 25535 31588984
Rectal obstruction 15.77 15.73 4 82821 7 31614512
Nail disorder 15.76 15.73 22 82803 1873 31612646
Prostatic calcification 15.76 15.73 7 82818 101 31614418

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuropathy peripheral 2642.68 15.28 2026 125262 124870 70676286
Neutropenia 1522.12 15.28 2079 125209 255077 70546079
Disease progression 1514.08 15.28 1625 125663 155047 70646109
Neurotoxicity 1317.21 15.28 762 126526 29064 70772092
Thrombocytopenia 1147.34 15.28 1751 125537 237359 70563797
Diarrhoea 1004.77 15.28 3378 123910 779963 70021193
Laryngospasm 928.07 15.28 319 126969 3324 70797832
Palmar-plantar erythrodysaesthesia syndrome 918.84 15.28 609 126679 29638 70771518
Dermatitis acneiform 851.70 15.28 384 126904 8561 70792595
Skin toxicity 755.93 15.28 331 126957 6867 70794289
Arteriospasm coronary 724.78 15.28 305 126983 5719 70795437
Paraesthesia 695.61 15.28 1065 126223 144472 70656684
Mucosal inflammation 602.28 15.28 674 126614 67176 70733980
Myelosuppression 590.09 15.28 465 126823 29680 70771476
Peripheral sensory neuropathy 576.22 15.28 325 126963 11785 70789371
Metastases to liver 547.46 15.28 418 126870 25460 70775696
Polyneuropathy 536.48 15.28 383 126905 21032 70780124
Vomiting 528.64 15.28 2282 125006 590829 70210327
Bone marrow failure 521.47 15.28 536 126752 48474 70752682
Arthralgia 519.85 15.28 132 127156 503258 70297898
Venoocclusive liver disease 468.99 15.28 272 127016 10406 70790750
Paronychia 449.16 15.28 230 127058 6844 70794312
Erythema 447.03 15.28 1057 126231 198506 70602650
Bronchospasm 410.73 15.28 335 126953 22457 70778699
Colorectal cancer metastatic 409.21 15.28 145 127143 1664 70799492
Chills 404.43 15.28 838 126450 143948 70657208
Portal hypertension 369.05 15.28 196 127092 6296 70794860
Headache 367.86 15.28 302 126986 580103 70221053
Nausea 365.64 15.28 2693 124595 849395 69951761
Interstitial lung disease 365.63 15.28 666 126622 104019 70697137
Haematotoxicity 359.69 15.28 252 127036 13422 70787734
Drug ineffective 351.38 15.28 727 126561 939025 69862131
Enteritis 341.09 15.28 238 127050 12593 70788563
Joint swelling 340.88 15.28 31 127257 253180 70547976
Gastrointestinal toxicity 340.64 15.28 185 127103 6220 70794936
Product dose omission issue 330.24 15.28 14 127274 217454 70583702
Gastrointestinal perforation 327.13 15.28 173 127115 5508 70795648
Dysaesthesia pharynx 297.10 15.28 70 127218 137 70801019
Neoplasm progression 289.66 15.28 381 126907 44847 70756309
Fall 278.69 15.28 233 127055 443863 70357293
Cardiotoxicity 270.36 15.28 195 127093 10875 70790281
Pain 268.43 15.28 448 126840 628368 70172788
Metastases to lung 267.35 15.28 228 127060 16256 70784900
Throat tightness 264.86 15.28 273 127015 24749 70776407
Stridor 262.69 15.28 144 127144 4932 70796224
Neutrophil count decreased 256.22 15.28 503 126785 83053 70718103
Arthropathy 248.73 15.28 4 127284 150053 70651103
Drug abuse 243.77 15.28 4 127284 147252 70653904
Leukopenia 241.04 15.28 567 126721 105993 70695163
Malignant neoplasm progression 240.59 15.28 615 126673 121124 70680032
Type I hypersensitivity 238.83 15.28 122 127166 3610 70797546
Peripheral swelling 230.67 15.28 69 127219 236494 70564662
Weight increased 230.34 15.28 74 127214 242257 70558899
Focal nodular hyperplasia 225.97 15.28 73 127215 616 70800540
Dysarthria 218.14 15.28 397 126891 61916 70739240
Flushing 218.04 15.28 466 126822 81706 70719450
Hyperammonaemia 214.86 15.28 165 127123 10128 70791028
Sinusitis 214.04 15.28 26 127262 169169 70631987
Non-cirrhotic portal hypertension 213.21 15.28 62 127226 351 70800805
Decreased appetite 209.05 15.28 1089 126199 303691 70497465
Febrile neutropenia 207.45 15.28 820 126468 203498 70597658
Therapy partial responder 205.29 15.28 174 127114 12300 70788856
Nasopharyngitis 203.95 15.28 72 127216 222134 70579022
Contraindicated product administered 199.94 15.28 10 127278 134602 70666554
Hypomagnesaemia 199.55 15.28 302 126986 40462 70760694
Swelling 198.91 15.28 47 127241 188492 70612664
Stomatitis 197.23 15.28 592 126696 127919 70673237
Anaphylactic shock 194.69 15.28 265 127023 32225 70768931
Hyperammonaemic encephalopathy 194.61 15.28 113 127175 4330 70796826
Depression 194.02 15.28 58 127230 198916 70602240
Ascites 191.94 15.28 394 126894 67153 70734003
Drug interaction 190.63 15.28 243 127045 381198 70419958
Insomnia 185.94 15.28 79 127209 217727 70583429
Therapeutic product effect decreased 183.31 15.28 21 127267 142997 70658159
Abdominal pain 183.03 15.28 1144 126144 340983 70460173
Product use issue 181.82 15.28 49 127239 179888 70621268
Splenomegaly 180.34 15.28 195 127093 18675 70782481
Systemic lupus erythematosus 167.67 15.28 3 127285 101899 70699257
Dysphonia 166.29 15.28 312 126976 49788 70751368
Enterocolitis 165.05 15.28 157 127131 12909 70788247
Proteinuria 164.63 15.28 232 127056 29142 70772014
Asthma 164.58 15.28 14 127274 120779 70680377
Overdose 164.53 15.28 50 127238 169695 70631461
Psoriasis 161.54 15.28 3 127285 98430 70702726
Contusion 161.12 15.28 20 127268 128016 70673140
Feeling hot 160.18 15.28 302 126986 48368 70752788
Abdominal discomfort 158.97 15.28 94 127194 214564 70586592
Maternal exposure during pregnancy 158.17 15.28 13 127275 115332 70685824
Anastomotic leak 157.71 15.28 62 127226 967 70800189
Hyperhidrosis 157.52 15.28 557 126731 131029 70670127
Pyrexia 157.06 15.28 1721 125567 605231 70195925
Pain in extremity 156.73 15.28 216 127072 327866 70473290
Intestinal obstruction 152.20 15.28 260 127028 38565 70762591
Oxygen saturation decreased 149.95 15.28 505 126783 115924 70685232
Dyspnoea 144.94 15.28 2057 125231 768003 70033153
Influenza 144.94 15.28 17 127271 113683 70687473
Laryngeal discomfort 141.87 15.28 49 127239 518 70800638
Injection site pain 141.76 15.28 21 127267 117598 70683558
Nodular regenerative hyperplasia 140.75 15.28 61 127227 1232 70799924
Hypersensitivity 139.10 15.28 794 126494 229018 70572138
Cardiac failure congestive 134.73 15.28 38 127250 135419 70665737
Arthritis 134.45 15.28 11 127277 97969 70703187
Varices oesophageal 133.59 15.28 96 127192 5321 70795835
Asthenia 132.46 15.28 1328 125960 456338 70344818
Cytokine release syndrome 132.25 15.28 198 127090 26269 70774887
Pneumonia 132.10 15.28 586 126702 595646 70205510
Hyperthermia 131.60 15.28 156 127132 16515 70784641
Paraesthesia oral 131.28 15.28 150 127138 15267 70785889
Pemphigus 130.63 15.28 4 127284 83032 70718124
Dehydration 130.15 15.28 771 126517 225371 70575785
Dysaesthesia 129.80 15.28 94 127194 5274 70795882
Musculoskeletal stiffness 128.63 15.28 52 127236 147708 70653448
Intentional product misuse 128.33 15.28 3 127285 79592 70721564
Bronchitis 128.10 15.28 27 127261 117216 70683940
Anxiety 126.74 15.28 125 127163 220205 70580951
Carcinoembryonic antigen increased 125.96 15.28 65 127223 1965 70799191
Colon cancer metastatic 125.33 15.28 66 127222 2082 70799074
Tumour perforation 125.03 15.28 40 127248 326 70800830
Suicide attempt 124.47 15.28 4 127284 79506 70721650
Somnolence 124.39 15.28 122 127166 215484 70585672
Metastases to peritoneum 123.46 15.28 80 127208 3739 70797417
Large intestine perforation 121.98 15.28 134 127154 13061 70788095
Skin reaction 121.85 15.28 138 127150 13911 70787245
Glossodynia 120.67 15.28 9 127279 86478 70714678
Immune thrombocytopenia 119.46 15.28 147 127141 16177 70784979
Osteoarthritis 118.75 15.28 3 127285 74144 70727012
Drug intolerance 117.64 15.28 139 127149 225548 70575608
Lower respiratory tract infection 115.83 15.28 29 127259 111884 70689272
Hospitalisation 114.04 15.28 9 127279 82559 70718597
Intravascular haemolysis 112.53 15.28 44 127244 676 70800480
Condition aggravated 111.30 15.28 394 126894 427241 70373915
Posterior reversible encephalopathy syndrome 111.29 15.28 175 127113 24227 70776929
Myalgia 110.19 15.28 84 127204 167808 70633348
Wound 109.38 15.28 22 127266 98710 70702446
Laryngeal oedema 108.12 15.28 97 127191 7398 70793758
Ileus 108.03 15.28 172 127116 24065 70777091
Extravasation 106.97 15.28 70 127218 3327 70797829
Stress 104.36 15.28 4 127284 67962 70733194
Adenocarcinoma of colon 100.80 15.28 81 127207 5311 70795845
Exposure during pregnancy 100.46 15.28 18 127270 87699 70713457
Disseminated intravascular coagulation 100.19 15.28 200 127088 33398 70767758
Peritonitis 99.65 15.28 173 127115 25986 70775170
Intestinal perforation 99.36 15.28 133 127155 15911 70785245
Hepatic enzyme increased 98.68 15.28 82 127206 156908 70644248
Administration site extravasation 98.67 15.28 46 127242 1109 70800047
Blood cholesterol increased 98.52 15.28 4 127284 64600 70736556
Hypertransaminasaemia 97.20 15.28 99 127189 8844 70792312
Acute coronary syndrome 95.76 15.28 147 127141 19932 70781224
Injection site erythema 95.21 15.28 10 127278 72914 70728242
Hypertensive crisis 94.66 15.28 143 127145 19119 70782037
Colon cancer 93.85 15.28 122 127166 14184 70786972
Confusional state 92.64 15.28 236 127052 284162 70516994
Tumour necrosis 91.08 15.28 50 127238 1717 70799439
Cholinergic syndrome 90.60 15.28 40 127248 846 70800310
Portal shunt 90.26 15.28 22 127266 53 70801103
Haemolytic anaemia 88.74 15.28 129 127159 16665 70784491
Suicidal ideation 87.22 15.28 11 127277 69585 70731571
Inappropriate schedule of product administration 87.05 15.28 42 127246 107513 70693643
Dihydropyrimidine dehydrogenase deficiency 86.72 15.28 24 127264 110 70801046
Memory impairment 86.69 15.28 29 127259 92612 70708544
Pneumatosis intestinalis 86.53 15.28 77 127211 5810 70795346
General physical health deterioration 85.89 15.28 720 126568 235311 70565845
Mucosal toxicity 84.68 15.28 34 127254 562 70800594
Rhabdomyolysis 84.47 15.28 33 127255 95727 70705429
Mobility decreased 83.70 15.28 40 127248 102959 70698197
Hypokalaemia 83.07 15.28 459 126829 130729 70670427
Toxic leukoencephalopathy 82.87 15.28 39 127249 961 70800195
Incorrect dose administered 82.52 15.28 11 127277 66708 70734448
Platelet count decreased 80.61 15.28 572 126716 177650 70623506
Tongue oedema 80.56 15.28 76 127212 6183 70794973
Electrocardiogram QT prolonged 80.17 15.28 25 127263 83492 70717664
Tumour lysis syndrome 79.72 15.28 140 127148 21220 70779936
Fluid retention 79.48 15.28 10 127278 63375 70737781
Stomal varices 79.09 15.28 19 127269 42 70801114
Diffuse large B-cell lymphoma recurrent 77.58 15.28 58 127230 3418 70797738
Helicobacter infection 77.04 15.28 6 127282 55650 70745506
Off label use 76.47 15.28 1807 125481 741253 70059903
Drug hypersensitivity 76.37 15.28 230 127058 262229 70538927
Anaphylactic reaction 76.02 15.28 301 126987 74673 70726483
Treatment failure 75.91 15.28 88 127200 144054 70657102
Anastomotic complication 75.60 15.28 29 127259 422 70800734
Pericarditis 75.03 15.28 29 127259 84676 70716480
Osteoporosis 74.67 15.28 3 127285 48904 70752252
Migraine 74.20 15.28 19 127269 72219 70728937
Aggression 73.87 15.28 3 127285 48443 70752713
Rectal perforation 73.80 15.28 34 127254 797 70800359
Chronic obstructive pulmonary disease 73.18 15.28 24 127264 77617 70723539
Blood pressure fluctuation 72.34 15.28 10 127278 59002 70742154
Upper respiratory tract infection 72.13 15.28 26 127262 79248 70721908
Pulmonary embolism 70.91 15.28 501 126787 155366 70645790
Stress cardiomyopathy 70.86 15.28 88 127200 9774 70791382
Leukoencephalopathy 70.78 15.28 76 127212 7218 70793938
Cholangitis 70.39 15.28 95 127193 11454 70789702
Injection site reaction 70.07 15.28 5 127283 49847 70751309
Electrocardiogram ST segment elevation 69.90 15.28 77 127211 7527 70793629
Anastomotic fistula 69.72 15.28 20 127268 107 70801049
Feeling abnormal 68.56 15.28 93 127195 142226 70658930
Myocardial infarction 67.75 15.28 128 127160 171517 70629639
Blister 67.61 15.28 49 127239 100477 70700679
Nicotinic acid deficiency 67.22 15.28 21 127267 157 70800999
Anaemia 67.03 15.28 1056 126232 402367 70398789
Cyanosis 66.63 15.28 136 127152 23070 70778086
Vascular pain 66.49 15.28 32 127256 830 70800326
Rash pustular 66.21 15.28 87 127201 10221 70790935
Metastases to lymph nodes 65.68 15.28 82 127206 9156 70792000
Coronary artery disease 65.40 15.28 16 127272 62720 70738436
Hiccups 65.40 15.28 81 127207 8971 70792185
Rectal cancer 65.10 15.28 51 127237 3223 70797933
Rectal cancer metastatic 64.25 15.28 27 127261 504 70800652
Neuromyotonia 63.27 15.28 18 127270 93 70801063
Blood glucose increased 63.22 15.28 55 127233 102927 70698229
Hallucination 62.90 15.28 29 127259 76231 70724925
Evans syndrome 62.50 15.28 25 127263 409 70800747
Sedation 62.06 15.28 6 127282 46725 70754431
Drug reaction with eosinophilia and systemic symptoms 62.05 15.28 14 127274 57999 70743157
Hypoalbuminaemia 60.85 15.28 117 127171 19005 70782151
Subileus 60.73 15.28 60 127228 5167 70795989
Gastric perforation 60.29 15.28 52 127236 3763 70797393
Choking sensation 60.17 15.28 51 127237 3604 70797552
Metastasis 59.85 15.28 64 127224 6050 70795106
Infusion related reaction 59.76 15.28 579 126709 196955 70604201
Band sensation 59.72 15.28 28 127260 684 70800472
Duodenal ulcer perforation 59.59 15.28 10 127278 51102 70750054
Herpes zoster 59.36 15.28 40 127248 85195 70715961
Cellulitis 59.33 15.28 54 127234 98874 70702282
Dizziness 59.25 15.28 540 126748 463601 70337555
Periportal sinus dilatation 58.89 15.28 14 127274 29 70801127
Influenza like illness 58.47 15.28 22 127266 65309 70735847
Tachycardia 58.35 15.28 485 126803 158061 70643095
Stoma site haemorrhage 58.21 15.28 37 127251 1672 70799484
Injection site pruritus 57.92 15.28 3 127285 39207 70761949
Septic shock 57.73 15.28 372 126916 111886 70689270
Gastrointestinal anastomotic leak 57.21 15.28 24 127264 446 70800710
Discomfort 56.99 15.28 63 127225 105373 70695783
Sleep disorder 56.97 15.28 27 127261 69845 70731311
Speech disorder 56.97 15.28 210 127078 50370 70750786
Treatment noncompliance 56.83 15.28 8 127280 46566 70754590
Chemical peritonitis 56.82 15.28 21 127267 274 70800882
Diffuse large B-cell lymphoma refractory 56.79 15.28 33 127255 1266 70799890
Large intestinal obstruction 56.66 15.28 45 127243 2901 70798255
Palmar erythema 56.40 15.28 37 127251 1766 70799390
COVID-19 56.28 15.28 64 127224 105693 70695463
Gait disturbance 56.16 15.28 159 127129 184947 70616209
ECG signs of myocardial ischaemia 56.14 15.28 22 127266 340 70800816
Hepatic atrophy 55.75 15.28 23 127265 409 70800747
Nasal congestion 55.70 15.28 24 127264 65648 70735508
Cough 55.51 15.28 349 126939 325028 70476128
Encapsulating peritoneal sclerosis 55.42 15.28 28 127260 809 70800347
Wrong technique in product usage process 55.32 15.28 27 127261 68671 70732485
Ocular toxicity 55.29 15.28 28 127260 813 70800343
Hyperbilirubinaemia 55.28 15.28 124 127164 22444 70778712
Drug dependence 54.68 15.28 3 127285 37318 70763838
Oesophageal varices haemorrhage 54.42 15.28 49 127239 3754 70797402
Necrotising fasciitis 54.37 15.28 58 127230 5468 70795688
International normalised ratio increased 53.44 15.28 40 127248 80686 70720470
Drug level increased 53.22 15.28 3 127285 36466 70764690
Hepatic failure 52.60 15.28 224 127064 57401 70743755
Psychotic disorder 52.36 15.28 4 127284 37697 70763459
Recall phenomenon 51.93 15.28 29 127259 1030 70800126
Emotional distress 51.50 15.28 4 127284 37184 70763972
Dysphagia 51.48 15.28 363 126925 112471 70688685
Enterocutaneous fistula 51.06 15.28 34 127254 1664 70799492
Hypervolaemia 50.43 15.28 6 127282 39700 70761456
Hypertension 50.29 15.28 778 126510 295255 70505901
Prinzmetal angina 50.23 15.28 33 127255 1579 70799577
Splenorenal shunt 50.02 15.28 11 127277 13 70801143
Urinary tract infection 49.91 15.28 253 127035 248516 70552640
Diabetes mellitus 49.62 15.28 34 127254 71790 70729366
Metastases to spleen 49.58 15.28 23 127265 548 70800608
Colorectal cancer 49.09 15.28 68 127220 8402 70792754
Anaphylactoid reaction 48.29 15.28 52 127236 4955 70796201
Breast cancer 48.22 15.28 3 127285 33546 70767610
Productive cough 47.88 15.28 42 127246 78295 70722861
Biliary tract infection 47.79 15.28 29 127259 1206 70799950
Ileal perforation 47.17 15.28 26 127262 900 70800256
Acute abdomen 46.86 15.28 40 127248 2854 70798302
Transdifferentiation of neoplasm 46.63 15.28 14 127274 90 70801066
Medication error 46.38 15.28 22 127266 56890 70744266
Hypercreatinaemia 46.18 15.28 18 127270 274 70800882
Cataract 46.14 15.28 21 127267 55624 70745532
Enterovesical fistula 45.99 15.28 27 127261 1056 70800100
Viral infection 45.91 15.28 7 127281 38384 70762772
Malignant ascites 45.58 15.28 27 127261 1074 70800082
Portal venous gas 45.29 15.28 19 127269 353 70800803
Hyperpyrexia 45.27 15.28 52 127236 5322 70795834
Metastases to bone marrow 44.97 15.28 23 127265 682 70800474
Liver function test abnormal 44.90 15.28 27 127261 61119 70740037
Infusion related hypersensitivity reaction 44.85 15.28 17 127271 239 70800917
Steatohepatitis 44.50 15.28 24 127264 795 70800361
Formication 44.27 15.28 48 127240 4609 70796547
White blood cell count decreased 43.97 15.28 483 126805 169658 70631498
Head injury 43.75 15.28 5 127283 34136 70767020
Skin fissures 43.53 15.28 75 127213 11195 70789961
Small intestinal perforation 43.51 15.28 39 127249 2970 70798186
Haemoglobinuria 43.43 15.28 23 127265 734 70800422
Cold sweat 43.37 15.28 95 127193 16921 70784235
Pulmonary toxicity 43.21 15.28 73 127215 10725 70790431
Type II hypersensitivity 42.90 15.28 11 127277 35 70801121
Oxygen saturation normal 42.60 15.28 8 127280 0 70801156
Hyperkalaemia 42.48 15.28 79 127209 106512 70694644
Wound dehiscence 42.38 15.28 54 127234 6154 70795002
Metastases to meninges 42.13 15.28 39 127249 3097 70798059
Heart rate decreased 41.99 15.28 30 127258 61985 70739171
Performance status decreased 41.89 15.28 51 127237 5550 70795606
Oropharyngeal discomfort 41.69 15.28 53 127235 6026 70795130
Type 2 diabetes mellitus 40.88 15.28 14 127274 44066 70757090
Colitis 40.85 15.28 224 127064 63590 70737566
Laryngeal dyspnoea 40.56 15.28 16 127272 252 70800904
Oropharyngeal pain 40.52 15.28 69 127219 96241 70704915
Amaurosis fugax 40.51 15.28 23 127265 844 70800312
Peripheral motor neuropathy 40.25 15.28 38 127250 3094 70798062
Cardiac disorder 39.89 15.28 29 127259 59386 70741770
Hypoglycaemia 39.34 15.28 68 127220 94296 70706860
Neck pain 39.23 15.28 37 127251 66620 70734536
Trismus 39.12 15.28 47 127241 5044 70796112
Temperature intolerance 39.00 15.28 62 127226 8661 70792495
Rhinorrhoea 38.88 15.28 37 127251 66334 70734822
Nervousness 38.79 15.28 5 127283 31115 70770041
Basal cell carcinoma 38.39 15.28 7 127281 33691 70767465
Blood pressure systolic increased 38.37 15.28 28 127260 57231 70743925
Unevaluable event 38.21 15.28 23 127265 52040 70749116
Acute respiratory distress syndrome 38.14 15.28 161 127127 41093 70760063
Road traffic accident 37.84 15.28 8 127280 34674 70766482
Hypovolaemic shock 37.84 15.28 69 127219 10768 70790388
Loss of personal independence in daily activities 37.43 15.28 59 127229 84851 70716305
Hepatocellular injury 37.40 15.28 173 127115 45918 70755238
Small intestinal obstruction 37.22 15.28 113 127175 24542 70776614
Portal vein thrombosis 37.17 15.28 47 127241 5315 70795841
Aortitis 37.09 15.28 26 127262 1385 70799771
Cold dysaesthesia 37.07 15.28 8 127280 8 70801148
K-ras gene mutation 37.03 15.28 10 127278 41 70801115
Neutropenic sepsis 36.73 15.28 113 127175 24717 70776439
Colitis ulcerative 36.65 15.28 8 127280 33915 70767241
Balance disorder 36.62 15.28 66 127222 90062 70711094
Hypertrichosis 36.50 15.28 24 127264 1150 70800006
Hydronephrosis 36.50 15.28 83 127205 15159 70785997
Portal vein dilatation 36.28 15.28 10 127278 45 70801111
Haematoma 36.09 15.28 21 127267 48397 70752759
Factor VII deficiency 36.01 15.28 9 127279 25 70801131
Underdose 35.96 15.28 5 127283 29378 70771778
Abnormal behaviour 35.89 15.28 9 127279 34700 70766456
Hallucination, visual 35.89 15.28 5 127283 29332 70771824
Irritability 35.69 15.28 12 127276 38213 70762943
Lip oedema 35.67 15.28 47 127241 5536 70795620
Gastrooesophageal reflux disease 35.60 15.28 68 127220 90771 70710385
Splenic artery thrombosis 34.94 15.28 10 127278 53 70801103
Jaundice 34.88 15.28 180 127108 49928 70751228
Perforation 34.87 15.28 24 127264 1241 70799915
Embolism 34.81 15.28 74 127214 12914 70788242
Full blood count abnormal 34.62 15.28 9 127279 33869 70767287
Pharyngeal paraesthesia 34.41 15.28 30 127258 2202 70798954
Neutropenic colitis 34.15 15.28 44 127244 5070 70796086
Obesity 34.11 15.28 4 127284 26767 70774389
Blood pressure immeasurable 33.71 15.28 28 127260 1924 70799232
Abortion spontaneous 33.63 15.28 4 127284 26475 70774681
Hypotension 33.40 15.28 956 126332 403425 70397731
Product prescribing error 33.40 15.28 14 127274 38938 70762218
Sensation of foreign body 33.14 15.28 42 127246 4760 70796396
Peripheral sensorimotor neuropathy 33.04 15.28 32 127256 2690 70798466
Guillain-Barre syndrome 33.03 15.28 55 127233 7985 70793171
Accidental overdose 32.84 15.28 11 127277 35110 70766046
Toxic epidermal necrolysis 32.68 15.28 15 127273 39542 70761614
Muscle contractions involuntary 32.66 15.28 35 127253 3316 70797840
Aortic thrombosis 32.49 15.28 25 127263 1538 70799618
Respiratory distress 32.44 15.28 188 127100 54462 70746694
Oedema peripheral 32.34 15.28 258 127030 227833 70573323
Metastases to ovary 32.29 15.28 14 127274 283 70800873
Granulocyte count decreased 32.12 15.28 24 127264 1413 70799743
Right ventricular ejection fraction decreased 32.05 15.28 9 127279 44 70801112
Noninfective epididymitis 31.95 15.28 6 127282 0 70801156
Biliary fistula 31.75 15.28 10 127278 77 70801079
Intentional product use issue 31.62 15.28 110 127178 120032 70681124
Haemolytic uraemic syndrome 31.53 15.28 38 127250 4092 70797064
Trichomegaly 31.42 15.28 10 127278 80 70801076
Cystitis radiation 31.29 15.28 11 127277 123 70801033
Oesophageal haemorrhage 31.23 15.28 25 127263 1630 70799526
Haemolysis 31.17 15.28 66 127222 11485 70789671
Dysgeusia 31.17 15.28 173 127115 49329 70751827
Liver abscess 31.03 15.28 44 127244 5555 70795601
Short-bowel syndrome 31.02 15.28 16 127272 483 70800673
Femur fracture 30.96 15.28 13 127275 36119 70765037
Retching 30.76 15.28 80 127208 15899 70785257
Eosinophilia 30.75 15.28 17 127271 40302 70760854
Pancreatic carcinoma metastatic 30.41 15.28 36 127252 3804 70797352
Intestinal ischaemia 30.35 15.28 67 127221 11997 70789159
Pulmonary artery thrombosis 30.27 15.28 22 127266 1241 70799915
Thrombotic microangiopathy 30.00 15.28 85 127203 17763 70783393
Hepatic function abnormal 29.98 15.28 217 127071 67779 70733377
Cytomegalovirus infection 29.98 15.28 17 127271 39741 70761415
Adverse drug reaction 29.79 15.28 31 127257 53313 70747843
Suffocation feeling 29.78 15.28 24 127264 1580 70799576
Haematemesis 29.71 15.28 169 127119 48628 70752528
Thrombocytopenic purpura 29.70 15.28 28 127260 2276 70798880
Adverse event 29.64 15.28 27 127261 49434 70751722
Cytopenia 29.61 15.28 83 127205 17240 70783916
Hypophagia 29.40 15.28 150 127138 41420 70759736
Perforation bile duct 29.39 15.28 8 127280 34 70801122
Nephrolithiasis 29.37 15.28 25 127263 47298 70753858
Appendicitis noninfective 29.29 15.28 7 127281 15 70801141
Osteomyelitis 29.22 15.28 9 127279 30309 70770847
Hypersplenism 29.11 15.28 15 127273 452 70800704
Ear pain 28.84 15.28 7 127281 27592 70773564
Alopecia 28.84 15.28 223 127065 198267 70602889
Toxicity to various agents 28.60 15.28 498 126790 381674 70419482
Failure to anastomose 28.55 15.28 12 127276 224 70800932
Adenocarcinoma 28.52 15.28 34 127254 3619 70797537
Fatigue 28.52 15.28 1200 126088 823119 69978037
Pelvic abscess 28.41 15.28 25 127263 1858 70799298
Heart rate irregular 28.36 15.28 9 127279 29734 70771422
Localised infection 28.30 15.28 12 127276 33146 70768010
Hyperaemia 28.18 15.28 30 127258 2821 70798335
Autoimmune haemolytic anaemia 27.91 15.28 50 127238 7696 70793460
Oral dysaesthesia 27.90 15.28 11 127277 173 70800983
Congestive cardiomyopathy 27.85 15.28 61 127227 10865 70790291
Medical device site extravasation 27.80 15.28 6 127282 6 70801150
Pelvic fluid collection 27.76 15.28 17 127271 719 70800437
Carbohydrate antigen 19-9 increased 27.75 15.28 14 127274 403 70800753
Sciatic nerve palsy 27.75 15.28 9 127279 77 70801079
Blood glucose decreased 27.56 15.28 5 127283 24154 70777002
Hepatectomy 27.55 15.28 11 127277 179 70800977
Hypothyroidism 27.39 15.28 25 127263 45730 70755426
Device issue 27.35 15.28 5 127283 24020 70777136
Tumour ulceration 27.28 15.28 11 127277 184 70800972
Multiple sclerosis 27.24 15.28 6 127282 25279 70775877
Tooth disorder 27.21 15.28 5 127283 23933 70777223
Musculoskeletal pain 27.07 15.28 78 127210 90249 70710907
Gastric varices haemorrhage 26.98 15.28 13 127275 338 70800818
Koebner phenomenon 26.98 15.28 8 127280 49 70801107
Perineal disorder 26.90 15.28 7 127281 24 70801132
Blood creatine phosphokinase increased 26.59 15.28 43 127245 61220 70739936
Tendonitis 26.53 15.28 4 127284 22118 70779038
Hyperfibrinolysis 26.47 15.28 7 127281 26 70801130
Hypoacusis 26.46 15.28 8 127280 27261 70773895
Impaired healing 26.33 15.28 59 127229 74315 70726841
Oesophagitis 26.30 15.28 95 127193 22557 70778599
Device related infection 26.26 15.28 121 127167 32064 70769092
Hypoaesthesia oral 26.21 15.28 64 127224 12236 70788920
Skin laceration 26.20 15.28 7 127281 25871 70775285
Endothelial dysfunction 26.09 15.28 11 127277 207 70800949
Blood pressure diastolic decreased 26.05 15.28 7 127281 25773 70775383
Poor quality sleep 26.03 15.28 3 127285 20346 70780810
Chest discomfort 25.93 15.28 339 126949 124042 70677114
Death 25.92 15.28 707 126581 509354 70291802
Hepatic encephalopathy 25.89 15.28 93 127195 22025 70779131
Pharyngeal dyskinesia 25.82 15.28 8 127280 58 70801098
Necrotising oesophagitis 25.70 15.28 16 127272 697 70800459
Fistula of small intestine 25.70 15.28 16 127272 697 70800459
Gait inability 25.69 15.28 28 127260 47147 70754009
Dry eye 25.52 15.28 13 127275 32269 70768887
Cholestasis 25.43 15.28 160 127128 47712 70753444
Mucosal disorder 25.36 15.28 30 127258 3168 70797988
Premature delivery 25.21 15.28 4 127284 21300 70779856
Gastrointestinal necrosis 25.15 15.28 38 127250 5080 70796076
Full blood count decreased 25.12 15.28 6 127282 23912 70777244
Pulmonary hypertension 24.93 15.28 28 127260 46508 70754648
Tonic clonic movements 24.92 15.28 24 127264 2003 70799153
Night sweats 24.83 15.28 25 127263 43659 70757497
Sinus bradycardia 24.67 15.28 6 127282 23617 70777539
Rectal cancer recurrent 24.63 15.28 7 127281 36 70801120
Haemorrhage intracranial 24.53 15.28 7 127281 24770 70776386
Pseudocirrhosis 24.46 15.28 15 127273 636 70800520
Oropharyngeal spasm 24.43 15.28 12 127276 326 70800830
Drug ineffective for unapproved indication 24.36 15.28 20 127268 38518 70762638
Abdominal wall oedema 24.28 15.28 5 127283 3 70801153
Acute polyneuropathy 24.26 15.28 13 127275 425 70800731
Gene mutation 24.24 15.28 25 127263 2266 70798890
Limb injury 24.19 15.28 8 127280 25744 70775412
Diffuse large B-cell lymphoma 23.99 15.28 65 127223 13237 70787919
Gastrointestinal stoma complication 23.98 15.28 25 127263 2295 70798861
Pulmonary fibrosis 23.70 15.28 123 127165 34187 70766969
Loss of consciousness 23.69 15.28 402 126886 155314 70645842
Post embolisation syndrome 23.65 15.28 8 127280 79 70801077
Subacute cutaneous lupus erythematosus 23.61 15.28 29 127259 3184 70797972
Platelet count increased 23.56 15.28 4 127284 20269 70780887
Intervertebral disc protrusion 23.38 15.28 5 127283 21498 70779658
Nephrotic syndrome 23.35 15.28 56 127232 10584 70790572
Atypical haemolytic uraemic syndrome 23.34 15.28 16 127272 822 70800334
Perihepatic abscess 23.33 15.28 9 127279 133 70801023
Vasospasm 23.28 15.28 17 127271 966 70800190
Respiratory arrest 23.27 15.28 38 127250 53895 70747261
Abdominal abscess 23.11 15.28 42 127246 6536 70794620
Retroperitoneal abscess 23.07 15.28 12 127276 369 70800787
Product substitution issue 23.01 15.28 3 127285 18510 70782646
Mixed adenoneuroendocrine carcinoma 22.96 15.28 6 127282 21 70801135
Acral peeling skin syndrome 22.81 15.28 7 127281 49 70801107
Therapy interrupted 22.79 15.28 8 127280 24794 70776362
Livedo reticularis 22.78 15.28 31 127257 3767 70797389
Obstruction gastric 22.76 15.28 20 127268 1484 70799672
Hallucination, auditory 22.71 15.28 3 127285 18325 70782831
Hepatic lesion 22.70 15.28 40 127248 6077 70795079
Catheter site extravasation 22.69 15.28 12 127276 382 70800774
Seizure 22.66 15.28 207 127081 177755 70623401
Interventricular septum rupture 22.54 15.28 6 127282 23 70801133
Pain in jaw 22.50 15.28 26 127262 42643 70758513
Cardiomegaly 22.41 15.28 8 127280 24537 70776619
Infection 22.38 15.28 256 127032 210529 70590627
Surgery 22.36 15.28 13 127275 29976 70771180
Hypersomnia 22.22 15.28 5 127283 20759 70780397
Adenocarcinoma gastric 22.19 15.28 21 127267 1715 70799441
Organising pneumonia 22.17 15.28 53 127235 9997 70791159
Renal hydrocele 22.14 15.28 6 127282 25 70801131
Hyperlipasaemia 22.14 15.28 17 127271 1043 70800113
Disease recurrence 22.08 15.28 129 127159 37474 70763682
Allodynia 22.04 15.28 19 127269 1374 70799782
Protein urine 22.00 15.28 19 127269 1377 70799779
Pancreatic neuroendocrine tumour metastatic 21.97 15.28 9 127279 157 70800999
Epistaxis 21.93 15.28 281 127007 102346 70698810
Limbic encephalitis 21.87 15.28 15 127273 771 70800385
Gout 21.87 15.28 7 127281 22999 70778157
Venoocclusive disease 21.81 15.28 32 127256 4168 70796988
Labelled drug-drug interaction medication error 21.79 15.28 8 127280 24119 70777037
Pigmentation disorder 21.79 15.28 35 127253 4931 70796225
Microangiopathic haemolytic anaemia 21.77 15.28 19 127269 1397 70799759
Metastases to muscle 21.76 15.28 11 127277 318 70800838
Rectal adenocarcinoma 21.72 15.28 19 127269 1401 70799755
Gallbladder disorder 21.71 15.28 3 127285 17709 70783447
Blood alkaline phosphatase abnormal 21.63 15.28 15 127273 785 70800371
Blood potassium increased 21.60 15.28 11 127277 27315 70773841
Eczema impetiginous 21.59 15.28 6 127282 28 70801128
Astringent therapy 21.59 15.28 6 127282 28 70801128
Cardiospasm 21.59 15.28 6 127282 28 70801128
Fingerprint loss 21.57 15.28 7 127281 60 70801096
Peripheral nerve injury 21.51 15.28 14 127274 659 70800497
Hepatic vein stenosis 21.37 15.28 7 127281 62 70801094
Proctitis 21.27 15.28 29 127259 3529 70797627
Prostatic calcification 21.27 15.28 7 127281 63 70801093
Tremor 21.27 15.28 395 126893 155229 70645927
Female genital tract fistula 21.20 15.28 27 127261 3076 70798080
No adverse event 21.19 15.28 16 127272 32137 70769019
Cardiac ventricular disorder 21.15 15.28 11 127277 338 70800818
Ischiorectal hernia 21.15 15.28 5 127283 10 70801146
Hand-foot-genital syndrome 21.15 15.28 5 127283 10 70801146
Axonal and demyelinating polyneuropathy 21.15 15.28 5 127283 10 70801146
Venous thrombosis limb 21.09 15.28 31 127257 4044 70797112
Skin disorder 21.09 15.28 109 127179 30248 70770908
Musculoskeletal disorder 21.00 15.28 5 127283 19966 70781190
Oedema 20.94 15.28 105 127183 103476 70697680
Sciatica 20.88 15.28 9 127279 24618 70776538
Hiatus hernia 20.87 15.28 6 127282 21128 70780028
Liver function test increased 20.86 15.28 18 127270 33829 70767327
Toothache 20.63 15.28 4 127284 18426 70782730
Hemiparaesthesia 20.57 15.28 8 127280 121 70801035
Cachexia 20.55 15.28 51 127237 9849 70791307
Skin discolouration 20.50 15.28 22 127266 37303 70763853
Amnesia 20.47 15.28 39 127249 52116 70749040
Hypocapnia 20.36 15.28 13 127275 592 70800564
Therapeutic response unexpected 20.31 15.28 4 127284 18227 70782929
Vocal cord paralysis 20.31 15.28 23 127265 2318 70798838
Oesophageal fistula 20.30 15.28 11 127277 368 70800788
Tumour haemorrhage 20.26 15.28 29 127259 3693 70797463
Hepatic infarction 20.26 15.28 15 127273 871 70800285
Gastric disorder 20.20 15.28 18 127270 33304 70767852
Swelling face 20.08 15.28 53 127235 63111 70738045
Induration 19.92 15.28 20 127268 1756 70799400
Thrombotic thrombocytopenic purpura 19.90 15.28 38 127250 6139 70795017
Delirium 19.84 15.28 68 127220 74546 70726610
Drug eruption 19.84 15.28 25 127263 39471 70761685
Gastrointestinal mucosal necrosis 19.81 15.28 9 127279 204 70800952
Diaphragmatic paralysis 19.75 15.28 16 127272 1061 70800095
Musculoskeletal discomfort 19.69 15.28 4 127284 17828 70783328
Catheter site bruise 19.51 15.28 10 127278 298 70800858
Impaired work ability 19.49 15.28 3 127285 16337 70784819
Dry skin 19.44 15.28 169 127119 55762 70745394
Tachypnoea 19.32 15.28 102 127186 28536 70772620
Immunodeficiency 19.25 15.28 4 127284 17551 70783605
Therapy non-responder 19.19 15.28 72 127216 76843 70724313
Implant site dehiscence 19.19 15.28 6 127282 45 70801111
Anger 19.15 15.28 3 127285 16129 70785027
Peripheral ischaemia 19.12 15.28 46 127242 8712 70792444
Metastases to diaphragm 19.07 15.28 6 127282 46 70801110
Macroglossia 19.07 15.28 16 127272 1115 70800041
Product administration error 19.06 15.28 15 127273 29508 70771648
Heart rate increased 19.03 15.28 112 127176 106036 70695120
Anal sphincter atony 19.00 15.28 10 127278 315 70800841
Oesophagobronchial fistula 18.93 15.28 9 127279 227 70800929
Monocytopenia 18.86 15.28 8 127280 153 70801003
Eye pain 18.84 15.28 20 127268 34082 70767074
Catabolic state 18.83 15.28 7 127281 93 70801063
Infusion site hypoaesthesia 18.82 15.28 5 127283 19 70801137
Chemotherapy cardiotoxicity attenuation 18.82 15.28 5 127283 19 70801137
Lymphangiosis carcinomatosa 18.78 15.28 20 127268 1881 70799275
Mental impairment 18.78 15.28 4 127284 17251 70783905
Mucocutaneous rash 18.64 15.28 6 127282 50 70801106
Restless legs syndrome 18.63 15.28 5 127283 18423 70782733
Pulmonary congestion 18.62 15.28 11 127277 25143 70776013
Impaired quality of life 18.58 15.28 46 127242 8870 70792286
Bradycardia 18.56 15.28 139 127149 124476 70676680
Extrapyramidal disorder 18.54 15.28 7 127281 20743 70780413
Intrahepatic portal hepatic venous fistula 18.53 15.28 4 127284 4 70801152
Neonatal asphyxia 18.53 15.28 4 127284 4 70801152
Inferior vena cava stenosis 18.53 15.28 6 127282 51 70801105
Eczema 18.45 15.28 20 127268 33761 70767395
Pruritus 18.45 15.28 777 126511 344783 70456373
Hypercholesterolaemia 18.16 15.28 5 127283 18112 70783044
Inflammation 18.13 15.28 76 127212 78589 70722567
Pneumoperitoneum 18.09 15.28 24 127264 2845 70798311
Cholelithiasis 18.06 15.28 36 127252 47304 70753852
Cognitive disorder 18.00 15.28 53 127235 60903 70740253
Aplastic anaemia 17.94 15.28 4 127284 16712 70784444
Bursitis 17.93 15.28 13 127275 26660 70774496
Osteopenia 17.91 15.28 4 127284 16693 70784463
Endometrial dysplasia 17.71 15.28 5 127283 25 70801131
Malaise 17.70 15.28 948 126340 431984 70369172
Radiation interaction 17.67 15.28 6 127282 60 70801096
Tetany 17.63 15.28 21 127267 2233 70798923
Metastases to retroperitoneum 17.56 15.28 10 127278 369 70800787
Fistula 17.49 15.28 51 127237 10830 70790326
Pneumonitis 17.46 15.28 162 127126 54435 70746721
Soft tissue necrosis 17.45 15.28 13 127275 762 70800394
Mental disorder 17.42 15.28 15 127273 28225 70772931
Mucosal necrosis 17.42 15.28 7 127281 116 70801040
Cerebrovascular accident 17.35 15.28 169 127119 143301 70657855
Splenic abscess 17.35 15.28 11 127277 495 70800661
Disability 17.31 15.28 3 127285 14980 70786176
Aortic intramural haematoma 17.31 15.28 7 127281 118 70801038
Pachymeningitis 17.26 15.28 9 127279 278 70800878
Therapy cessation 17.24 15.28 21 127267 33655 70767501
Tumour fistulisation 17.24 15.28 5 127283 28 70801128
VIth nerve disorder 17.24 15.28 5 127283 28 70801128
Palpitations 17.24 15.28 122 127166 110631 70690525
Feeling cold 17.20 15.28 91 127197 25479 70775677
Renal disorder 17.14 15.28 26 127262 37983 70763173
Nephritis allergic 17.09 15.28 12 127276 641 70800515
Gastrointestinal obstruction 17.03 15.28 17 127271 1482 70799674
Fear 17.02 15.28 8 127280 20803 70780353
Acute promyelocytic leukaemia 17.00 15.28 17 127271 1485 70799671
Depressed mood 16.99 15.28 33 127255 43787 70757369
Blood triglycerides increased 16.97 15.28 7 127281 19657 70781499
Colon cancer recurrent 16.94 15.28 7 127281 125 70801031
Motion sickness 16.85 15.28 13 127275 803 70800353
Aplasia 16.82 15.28 39 127249 7212 70793944
Laboratory test abnormal 16.82 15.28 13 127275 25810 70775346
Jaw operation 16.81 15.28 13 127275 806 70800350
Metastatic neoplasm 16.74 15.28 30 127258 4618 70796538
Cerebral vasoconstriction 16.73 15.28 16 127272 1324 70799832
Aortic dissection 16.73 15.28 27 127261 3820 70797336
Coombs test positive 16.71 15.28 8 127280 205 70800951
Lacrimation disorder 16.60 15.28 4 127284 9 70801147
Biliary cancer metastatic 16.60 15.28 4 127284 9 70801147
Blindness transient 16.45 15.28 29 127259 4407 70796749
Abdominal sepsis 16.45 15.28 19 127269 1956 70799200
Ichthyosis 16.40 15.28 7 127281 136 70801020
Vascular access site occlusion 16.32 15.28 6 127282 77 70801079
Venous injury 16.31 15.28 12 127276 690 70800466
Neutrophil count abnormal 16.29 15.28 24 127264 3137 70798019
Chronic myeloid leukaemia 16.28 15.28 28 127260 4173 70796983
Myoclonus 16.26 15.28 14 127274 26341 70774815
Neoplasm recurrence 16.24 15.28 27 127261 3914 70797242
Dementia 16.24 15.28 10 127278 22355 70778801
Xerosis 16.22 15.28 14 127274 1014 70800142
Colorectal cancer recurrent 16.19 15.28 6 127282 79 70801077
Onycholysis 16.13 15.28 18 127270 1785 70799371
Gastritis 16.09 15.28 35 127253 44556 70756600
Hyperthyroidism 16.01 15.28 8 127280 20083 70781073
Hepatic fibrosis 15.98 15.28 35 127253 6232 70794924
Neuronal neuropathy 15.97 15.28 3 127285 0 70801156
Tunnel vision 15.94 15.28 15 127273 1216 70799940
Ventricular fibrillation 15.91 15.28 93 127195 27018 70774138
Movement disorder 15.91 15.28 12 127276 24117 70777039
Colonic fistula 15.89 15.28 11 127277 574 70800582
Hypertriglyceridaemia 15.87 15.28 52 127236 11759 70789397
Back pain 15.85 15.28 368 126920 270784 70530372
Ankle fracture 15.82 15.28 4 127284 15340 70785816
Sputum discoloured 15.81 15.28 7 127281 18844 70782312
Lymphadenopathy mediastinal 15.73 15.28 27 127261 4018 70797138
Sepsis 15.67 15.28 561 126727 243984 70557172
Gastric dilatation 15.66 15.28 15 127273 1243 70799913
Red blood cell count decreased 15.66 15.28 45 127243 52116 70749040
C-reactive protein increased 15.65 15.28 125 127163 110392 70690764
Tumour marker increased 15.65 15.28 26 127262 3768 70797388
Gastric varices 15.59 15.28 11 127277 592 70800564
Gastrointestinal stoma output increased 15.53 15.28 8 127280 241 70800915
Live birth 15.40 15.28 3 127285 13776 70787380
Pallor 15.40 15.28 126 127162 40848 70760308
Chronic kidney disease 15.33 15.28 57 127231 61000 70740156
Coombs positive haemolytic anaemia 15.32 15.28 13 127275 920 70800236
Sense of oppression 15.30 15.28 16 127272 1474 70799682

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01XA03 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
OTHER ANTINEOPLASTIC AGENTS
Platinum compounds
FDA EXT N0000175073 Platinum-containing Compounds
FDA EPC N0000175413 Platinum-based Drug
MeSH PA D000970 Antineoplastic Agents
CHEBI has role CHEBI:25435 mutagens
CHEBI has role CHEBI:35610 antineoplastic agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Metastasis from malignant tumor of colon indication 314998002
Small intestine cancer indication 363509000 DOID:10154
Lymph Node Positive Colorectal Carcinoma indication
Malignant tumor of colon off-label use 363406005 DOID:219
Malignant tumor of testis off-label use 363449006 DOID:2998
Adenocarcinoma of pancreas off-label use 700423003 DOID:4074
Fibrosis of lung contraindication 51615001 DOID:3770
Interstitial pneumonia contraindication 64667001
Kidney disease contraindication 90708001 DOID:557
Liver function tests abnormal contraindication 166603001
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Peripheral nerve disease contraindication 302226006
Breastfeeding (mother) contraindication 413712001




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4021355 VUID
N0000148774 NUI
D01790 KEGG_DRUG
4021355 VANDF
C0069717 UMLSCUI
CHEBI:31941 CHEBI
1PT PDB_CHEM_ID
CHEMBL414804 ChEMBL_ID
D000077150 MESH_DESCRIPTOR_UI
DB00526 DRUGBANK_ID
7433 IUPHAR_LIGAND_ID
6012 INN_ID
04ZR38536J UNII
9887053 PUBCHEM_CID
32592 RXNORM
165344 MMSL
16916 MMSL
d04811 MMSL
007166 NDDF
327032007 SNOMEDCT_US
395814003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-3985 INJECTION, SOLUTION, CONCENTRATE 50 mg INTRAVENOUS NDA 28 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-3985 INJECTION, SOLUTION, CONCENTRATE 50 mg INTRAVENOUS NDA 28 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-3986 INJECTION, SOLUTION, CONCENTRATE 100 mg INTRAVENOUS NDA 28 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-3986 INJECTION, SOLUTION, CONCENTRATE 100 mg INTRAVENOUS NDA 28 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 0781-3315 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 29 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 0781-3317 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 29 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 0781-9315 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 28 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 0781-9317 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 28 sections
OXALIPLATIN HUMAN PRESCRIPTION DRUG LABEL 1 0955-1725 INJECTION, SOLUTION, CONCENTRATE 5 mg INTRAVENOUS NDA AUTHORIZED GENERIC 33 sections
OXALIPLATIN HUMAN PRESCRIPTION DRUG LABEL 1 0955-1727 INJECTION, SOLUTION, CONCENTRATE 5 mg INTRAVENOUS NDA AUTHORIZED GENERIC 33 sections
OXALIPLATIN HUMAN PRESCRIPTION DRUG LABEL 1 0955-1731 INJECTION, SOLUTION, CONCENTRATE 5 mg INTRAVENOUS NDA AUTHORIZED GENERIC 33 sections
OXALIPLATIN HUMAN PRESCRIPTION DRUG LABEL 1 0955-1733 INJECTION, SOLUTION, CONCENTRATE 5 mg INTRAVENOUS NDA AUTHORIZED GENERIC 33 sections
oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 16714-727 INJECTION 5 mg INTRAVENOUS ANDA 27 sections
oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 16714-728 INJECTION 5 mg INTRAVENOUS ANDA 27 sections
oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 16729-332 INJECTION, SOLUTION, CONCENTRATE 5 mg INTRAVENOUS ANDA 30 sections
oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 25021-233 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 28 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 43066-014 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 28 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 43066-018 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 28 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 45963-611 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 5 mg INTRAVENOUS ANDA 20 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 45963-611 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 5 mg INTRAVENOUS ANDA 20 sections
Oxaliplatin Human Prescription Drug Label 1 47335-046 INJECTION, SOLUTION, CONCENTRATE 50 mg INTRAVENOUS ANDA 27 sections
Oxaliplatin Human Prescription Drug Label 1 47335-047 INJECTION, SOLUTION, CONCENTRATE 100 mg INTRAVENOUS ANDA 27 sections
Oxaliplatin Human Prescription Drug Label 1 47335-176 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 50 mg INTRAVENOUS ANDA 28 sections
Oxaliplatin Human Prescription Drug Label 1 47335-178 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS ANDA 28 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 50742-405 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 26 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 50742-406 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 26 sections
Oxaliplatin Human Prescription Drug Label 1 55150-331 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 29 sections
Oxaliplatin Human Prescription Drug Label 1 55150-332 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 29 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 57277-001 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 26 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 57277-002 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 26 sections