oxaliplatin ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antineoplastic agents, platinum derivatives 4210 61825-94-3

Description:

MoleculeDescription

Synonyms:

  • oxaliplatin
  • oxalatoplatin
  • oxalatoplatinum
  • elplat
An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS.
  • Molecular weight: 397.29
  • Formula: C8H14N2O4Pt
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 6 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 8.13 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.50 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.13 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 58.92 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 9, 2002 FDA
March 18, 2005 PMDA Yakult Honsha

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuropathy peripheral 1285.89 17.12 1010 64656 112657 63310699
Neutropenia 1103.53 17.12 1117 64549 173888 63249468
Disease progression 1081.93 17.12 944 64722 121814 63301542
Laryngospasm 1036.03 17.12 292 65374 2736 63420620
Neurotoxicity 809.71 17.12 381 65285 16609 63406747
Thrombocytopenia 780.11 17.12 868 64798 150289 63273067
Diarrhoea 625.95 17.12 1883 63783 713483 62709873
Mucosal inflammation 505.87 17.12 406 65260 46522 63376834
Palmar-plantar erythrodysaesthesia syndrome 482.03 17.12 299 65367 22716 63400640
Paraesthesia 468.52 17.12 687 64979 156279 63267077
Vomiting 448.70 17.12 1431 64235 558186 62865170
Myelosuppression 400.33 17.12 269 65397 23434 63399922
Stridor 364.17 17.12 137 65529 3373 63419983
Dermatitis acneiform 363.94 17.12 151 65515 4845 63418511
Polyneuropathy 353.07 17.12 208 65458 14381 63408975
Dysarthria 336.77 17.12 309 65357 42402 63380954
Arthralgia 328.29 17.12 92 65574 569618 62853738
Bone marrow failure 327.47 17.12 259 65407 29031 63394325
Peripheral sensory neuropathy 327.12 17.12 158 65508 7293 63416063
Arteriospasm coronary 319.99 17.12 129 65537 3839 63419517
Bronchospasm 303.56 17.12 201 65465 17079 63406277
Throat tightness 299.76 17.12 230 65436 24657 63398699
Nausea 296.40 17.12 1693 63973 852778 62570578
Skin toxicity 292.00 17.12 127 65539 4587 63418769
Dysaesthesia pharynx 276.89 17.12 57 65609 101 63423255
Joint swelling 271.82 17.12 17 65649 327649 63095707
Febrile neutropenia 254.90 17.12 447 65219 118002 63305354
Malignant neoplasm progression 249.78 17.12 363 65303 81758 63341598
Drug ineffective 240.34 17.12 449 65217 1044316 62379040
Metastases to liver 238.74 17.12 197 65469 23442 63399914
Haematotoxicity 230.33 17.12 135 65531 9241 63414115
Non-cirrhotic portal hypertension 225.98 17.12 52 65614 189 63423167
Arthropathy 222.85 17.12 4 65662 234788 63188568
Pain 217.41 17.12 269 65397 740359 62682997
Leukopenia 205.63 17.12 321 65345 76969 63346387
Gastrointestinal toxicity 204.88 17.12 117 65549 7624 63415732
Swelling 204.47 17.12 23 65643 275355 63148001
Headache 201.95 17.12 215 65451 633026 62790330
Product dose omission issue 200.88 17.12 10 65656 234303 63189053
Sinusitis 199.79 17.12 8 65658 226645 63196711
Contraindicated product administered 194.18 17.12 7 65659 217641 63205715
Systemic lupus erythematosus 192.59 17.12 5 65661 208913 63214443
Gastrointestinal perforation 190.32 17.12 86 65580 3405 63419951
Neutrophil count decreased 187.19 17.12 260 65406 56146 63367210
Paronychia 185.63 17.12 98 65568 5467 63417889
Posterior reversible encephalopathy syndrome 184.49 17.12 149 65517 17196 63406160
Dyspnoea 183.48 17.12 1239 64427 660074 62763282
Nasopharyngitis 181.96 17.12 24 65642 254233 63169123
Enteritis 181.95 17.12 111 65555 8175 63415181
Pemphigus 174.85 17.12 3 65663 183723 63239633
Erythema 171.48 17.12 483 65183 175268 63248088
Portal hypertension 170.70 17.12 82 65584 3737 63419619
Weight increased 163.68 17.12 35 65631 260757 63162599
Abdominal discomfort 161.46 17.12 65 65601 320820 63102536
Glossodynia 158.68 17.12 6 65660 178870 63244486
Therapeutic product effect decreased 151.56 17.12 13 65653 193174 63230182
Maternal exposure during pregnancy 147.70 17.12 25 65641 220037 63203319
Dehydration 144.87 17.12 451 65215 172903 63250453
Peripheral swelling 143.66 17.12 48 65618 265894 63157462
Anaphylactic shock 143.09 17.12 148 65518 23485 63399871
Wound 143.04 17.12 6 65660 163257 63260099
Laryngeal oedema 139.57 17.12 82 65584 5636 63417720
Hyperammonaemia 138.25 17.12 79 65587 5153 63418203
Abdominal pain 137.36 17.12 634 65032 292822 63130534
Fall 135.39 17.12 124 65542 392210 63031146
Ascites 134.00 17.12 187 65479 40541 63382815
Product use issue 133.53 17.12 32 65634 220488 63202868
Venoocclusive liver disease 130.43 17.12 74 65592 4761 63418595
Anaemia 130.06 17.12 624 65042 292806 63130550
Therapy partial responder 129.40 17.12 99 65567 10559 63412797
Chills 125.95 17.12 327 65339 113051 63310305
Enterocolitis 125.06 17.12 86 65580 7772 63415584
Asthenia 124.00 17.12 748 64918 382856 63040500
Colorectal cancer metastatic 122.30 17.12 39 65627 574 63422782
Depression 121.97 17.12 27 65639 196465 63226891
Lower respiratory tract infection 115.43 17.12 5 65661 132302 63291054
Splenomegaly 114.76 17.12 94 65572 11063 63412293
Asthma 114.08 17.12 4 65662 127557 63295799
Neoplasm progression 113.54 17.12 163 65503 36265 63387091
Immune thrombocytopenia 112.93 17.12 91 65575 10465 63412891
Dysphonia 110.57 17.12 186 65480 47428 63375928
Tongue oedema 109.92 17.12 65 65601 4521 63418835
Pericarditis 108.45 17.12 7 65659 131572 63291784
Hypokalaemia 105.78 17.12 290 65376 103514 63319842
Nodular regenerative hyperplasia 104.28 17.12 33 65633 473 63422883
Musculoskeletal stiffness 103.79 17.12 31 65635 184587 63238769
Hepatic enzyme increased 103.30 17.12 40 65626 202288 63221068
Bronchitis 101.92 17.12 7 65659 124928 63298428
Cardiotoxicity 101.60 17.12 78 65588 8360 63414996
Intestinal perforation 101.00 17.12 90 65576 11873 63411483
Dysaesthesia 100.91 17.12 61 65605 4417 63418939
Flushing 99.74 17.12 232 65434 74855 63348501
Insomnia 99.69 17.12 49 65617 215203 63208153
Metastases to peritoneum 99.15 17.12 55 65611 3387 63419969
Hypomagnesaemia 99.11 17.12 135 65531 28602 63394754
Large intestine perforation 96.90 17.12 76 65590 8406 63414950
Drug intolerance 96.73 17.12 106 65560 308555 63114801
Metastases to lung 96.08 17.12 90 65576 12660 63410696
Hyperammonaemic encephalopathy 96.04 17.12 48 65618 2386 63420970
Intestinal obstruction 95.91 17.12 138 65528 30761 63392595
Dysphagia 94.78 17.12 252 65414 88333 63335023
Hyperthermia 93.87 17.12 77 65589 9079 63414277
Anastomotic leak 93.73 17.12 30 65636 447 63422909
Paraesthesia oral 92.87 17.12 107 65559 19149 63404207
Focal nodular hyperplasia 92.38 17.12 31 65635 540 63422816
Speech disorder 92.06 17.12 157 65509 40472 63382884
Influenza 88.95 17.12 6 65660 108716 63314640
Contusion 88.41 17.12 23 65643 150021 63273335
General physical health deterioration 88.16 17.12 427 65239 200975 63222381
Pain in extremity 88.11 17.12 129 65537 331357 63091999
Decreased appetite 87.72 17.12 500 65166 250552 63172804
Exposure during pregnancy 87.63 17.12 26 65640 155521 63267835
Arthritis 85.15 17.12 10 65656 115911 63307445
Neuromyotonia 82.97 17.12 18 65648 46 63423310
Helicobacter infection 82.64 17.12 3 65663 92782 63330574
Psoriatic arthropathy 81.37 17.12 3 65663 91517 63331839
Alopecia 80.61 17.12 141 65525 337395 63085961
Injection site pain 80.19 17.12 18 65648 129782 63293574
Platelet count decreased 79.86 17.12 283 65383 115839 63307517
Treatment failure 79.78 17.12 54 65612 198989 63224367
Interstitial lung disease 79.72 17.12 189 65477 61719 63361637
Stress cardiomyopathy 77.62 17.12 70 65596 9380 63413976
Condition aggravated 77.50 17.12 190 65476 402027 63021329
Duodenal ulcer perforation 77.05 17.12 3 65663 87206 63336150
Ileus 76.42 17.12 85 65581 14640 63408716
Tachycardia 75.37 17.12 281 65385 117875 63305481
Discomfort 74.65 17.12 40 65626 167334 63256022
Drug hypersensitivity 73.97 17.12 130 65536 310557 63112799
Hyperhidrosis 72.61 17.12 261 65405 107575 63315781
Hospitalisation 71.69 17.12 4 65662 85077 63338279
Laryngeal discomfort 70.33 17.12 22 65644 303 63423053
Anaphylactic reaction 69.64 17.12 187 65479 65913 63357443
Hypertensive crisis 68.82 17.12 82 65584 15204 63408152
Stomatitis 68.68 17.12 305 65361 138420 63284936
Metastases to meninges 67.97 17.12 39 65627 2563 63420793
Band sensation 65.65 17.12 27 65639 846 63422510
Laryngeal dyspnoea 64.48 17.12 18 65648 162 63423194
Haemolytic anaemia 64.16 17.12 65 65601 10060 63413296
Acute coronary syndrome 64.16 17.12 65 65601 10061 63413295
Injection site erythema 64.10 17.12 6 65660 83168 63340188
Injury 63.11 17.12 3 65663 73244 63350112
Metastases to ovary 62.92 17.12 22 65644 436 63422920
Oxygen saturation decreased 62.71 17.12 218 65448 88367 63334989
Gastric varices haemorrhage 62.34 17.12 17 65649 139 63423217
Tumour perforation 61.87 17.12 16 65650 104 63423252
Cholinergic syndrome 60.27 17.12 22 65644 496 63422860
Pyrexia 59.87 17.12 746 64920 469732 62953624
Peritonitis 59.77 17.12 81 65585 17073 63406283
Blister 59.39 17.12 30 65636 129784 63293572
Drug abuse 59.32 17.12 4 65662 72514 63350842
Neutropenic colitis 59.23 17.12 38 65628 3057 63420299
Off label use 59.15 17.12 1002 64664 673460 62749896
Colitis 59.09 17.12 145 65521 48383 63374973
Cardiac failure congestive 58.75 17.12 12 65654 92421 63330935
Varices oesophageal 58.64 17.12 38 65628 3110 63420246
Cytokine release syndrome 56.71 17.12 72 65594 14242 63409114
Pancytopenia 56.45 17.12 224 65442 96709 63326647
Upper respiratory tract infection 55.71 17.12 9 65657 82038 63341318
Mobility decreased 53.94 17.12 29 65637 121130 63302226
Diffuse large B-cell lymphoma refractory 53.73 17.12 26 65640 1204 63422152
Enterocutaneous fistula 53.50 17.12 27 65639 1370 63421986
Chemical peritonitis 53.24 17.12 14 65652 98 63423258
Infusion related hypersensitivity reaction 53.19 17.12 17 65649 252 63423104
Somnolence 53.05 17.12 64 65602 178621 63244735
Suicidal ideation 52.38 17.12 3 65663 62418 63360938
Disseminated intravascular coagulation 51.83 17.12 80 65586 18971 63404385
Migraine 51.77 17.12 21 65645 103325 63320031
Stress 51.34 17.12 5 65661 67162 63356194
Mucosal toxicity 51.28 17.12 18 65648 361 63422995
Fatigue 51.23 17.12 631 65035 887397 62535959
Type I hypersensitivity 51.11 17.12 34 65632 2908 63420448
Suicide attempt 50.90 17.12 3 65663 60915 63362441
Intentional product misuse 50.90 17.12 3 65663 60914 63362442
Type 2 diabetes mellitus 50.87 17.12 4 65662 63864 63359492
Feeling hot 50.58 17.12 140 65526 50214 63373142
Tachypnoea 50.39 17.12 75 65591 17227 63406129
Extravasation 50.09 17.12 31 65635 2341 63421015
Fluid retention 49.69 17.12 3 65663 59683 63363673
Folliculitis 49.38 17.12 7 65659 70310 63353046
Evans syndrome 48.60 17.12 15 65651 197 63423159
White blood cell count decreased 48.47 17.12 277 65389 138827 63284529
Rectal perforation 48.46 17.12 18 65648 427 63422929
Memory impairment 47.83 17.12 24 65642 104234 63319122
Hypertension 47.40 17.12 469 65197 278834 63144522
Proteinuria 47.40 17.12 77 65589 19068 63404288
Cataract 47.10 17.12 3 65663 57050 63366306
Dysgeusia 47.05 17.12 130 65536 46580 63376776
Dihydropyrimidine dehydrogenase deficiency 46.95 17.12 12 65654 74 63423282
Ocular toxicity 46.83 17.12 20 65646 690 63422666
Sensation of foreign body 46.75 17.12 39 65627 4706 63418650
Inappropriate schedule of product administration 46.11 17.12 25 65641 103940 63319416
Hepatic failure 46.04 17.12 109 65557 35547 63387809
Hydronephrosis 46.04 17.12 56 65610 10606 63412750
Pneumonia 45.72 17.12 281 65385 456486 62966870
Injection site reaction 45.69 17.12 4 65662 58520 63364836
Diffuse large B-cell lymphoma recurrent 45.67 17.12 29 65637 2291 63421065
Anxiety 45.67 17.12 98 65568 217443 63205913
Choking sensation 45.32 17.12 34 65632 3520 63419836
Gait disturbance 45.06 17.12 75 65591 183103 63240253
Leukoencephalopathy 45 17.12 37 65629 4376 63418980
Carcinoembryonic antigen increased 44.89 17.12 26 65640 1739 63421617
Osteoporosis 44.54 17.12 4 65662 57334 63366022
Pharyngeal paraesthesia 44.32 17.12 27 65639 1982 63421374
Drug interaction 44.24 17.12 108 65558 229023 63194333
Sleep disorder 43.49 17.12 15 65651 81551 63341805
Oropharyngeal discomfort 43.27 17.12 39 65627 5221 63418135
Suffocation feeling 42.84 17.12 23 65643 1327 63422029
Overdose 42.48 17.12 34 65632 115044 63308312
Neutrophil count abnormal 42.16 17.12 30 65636 2862 63420494
Metastasis 41.70 17.12 38 65628 5159 63418197
Trichomegaly 41.59 17.12 11 65655 79 63423277
Cold dysaesthesia 41.46 17.12 8 65658 8 63423348
Splenic artery thrombosis 41.40 17.12 10 65656 47 63423309
Factor VII deficiency 40.94 17.12 9 65657 25 63423331
Muscle spasms 40.80 17.12 289 65377 155861 63267495
Blood lactate dehydrogenase abnormal 40.22 17.12 15 65651 360 63422996
Lymphoma 40.13 17.12 56 65610 12131 63411225
Chronic obstructive pulmonary disease 40.12 17.12 8 65658 62678 63360678
Skin fissures 40.02 17.12 54 65612 11334 63412022
Anastomotic fistula 39.48 17.12 9 65657 31 63423325
Thrombocytopenic purpura 39.44 17.12 22 65644 1369 63421987
Metastases to spleen 39.14 17.12 12 65654 154 63423202
Steatohepatitis 38.82 17.12 17 65649 624 63422732
Pharyngeal dyskinesia 38.43 17.12 9 65657 36 63423320
Cystitis radiation 38.03 17.12 10 65656 70 63423286
Septic shock 38.00 17.12 153 65513 66476 63356880
Congestive cardiomyopathy 37.92 17.12 39 65627 6143 63417213
Bladder tamponade 37.91 17.12 10 65656 71 63423285
Multiple organ dysfunction syndrome 37.86 17.12 137 65529 56615 63366741
Incorrect dose administered 37.66 17.12 8 65658 59960 63363396
Tremor 37.66 17.12 250 65416 131989 63291367
Hypertrichosis 37.57 17.12 20 65646 1134 63422222
Acute polyneuropathy 37.45 17.12 13 65653 252 63423104
Blood lactate dehydrogenase increased 36.99 17.12 77 65589 23039 63400317
Paralysis 36.41 17.12 48 65618 9852 63413504
Cardiac ventricular thrombosis 36.14 17.12 16 65650 603 63422753
Hyperpyrexia 36.09 17.12 30 65636 3602 63419754
Large intestinal obstruction 36.00 17.12 25 65641 2294 63421062
Short-bowel syndrome 35.80 17.12 15 65651 493 63422863
Formication 35.66 17.12 32 65634 4259 63419097
Vascular pain 35.54 17.12 17 65649 767 63422589
Infection 35.45 17.12 120 65546 229053 63194303
Injection site pruritus 35.44 17.12 3 65663 45113 63378243
Cough 35.37 17.12 169 65497 292574 63130782
Hepatic function abnormal 35.08 17.12 101 65565 37041 63386315
Confusional state 35.07 17.12 126 65540 236254 63187102
Abortion spontaneous 34.82 17.12 4 65662 47191 63376165
Inflammation 34.74 17.12 21 65645 82252 63341104
Illness 34.17 17.12 5 65661 49054 63374302
Hypoalbuminaemia 34.13 17.12 51 65615 11754 63411602
Pulmonary embolism 34.07 17.12 222 65444 116462 63306894
Hypertransaminasaemia 34.03 17.12 38 65628 6571 63416785
Ileal perforation 34.00 17.12 14 65652 440 63422916
Blood pressure fluctuation 33.99 17.12 4 65662 46313 63377043
ECG signs of myocardial ischaemia 33.98 17.12 9 65657 65 63423291
Chest discomfort 33.82 17.12 212 65454 109757 63313599
Muscle rigidity 33.70 17.12 50 65616 11450 63411906
Atypical haemolytic uraemic syndrome 33.51 17.12 16 65650 719 63422637
Adverse event 33.39 17.12 14 65652 67545 63355811
Myalgia 33.31 17.12 63 65603 146466 63276890
Gastric perforation 33.08 17.12 21 65645 1658 63421698
Mucosal necrosis 32.88 17.12 8 65658 39 63423317
Rash pustular 32.67 17.12 39 65627 7243 63416113
Thrombotic microangiopathy 32.52 17.12 47 65619 10514 63412842
Impaired healing 32.29 17.12 35 65631 102507 63320849
Palmar erythema 32.10 17.12 21 65645 1746 63421610
Loss of personal independence in daily activities 32 17.12 32 65634 97258 63326098
Perforation 31.62 17.12 18 65648 1165 63422191
Respiratory distress 30.79 17.12 91 65575 33860 63389496
Wrong technique in product usage process 30.68 17.12 13 65653 62327 63361029
Peripheral motor neuropathy 30.59 17.12 20 65646 1661 63421695
Trismus 30.38 17.12 28 65638 3857 63419499
Vocal cord paralysis 30.19 17.12 22 65644 2179 63421177
Autoimmune haemolytic anaemia 30 17.12 30 65636 4571 63418785
Haemolysis 29.96 17.12 36 65630 6732 63416624
Herpes zoster 29.64 17.12 25 65641 82437 63340919
Nicotinic acid deficiency 29.49 17.12 8 65658 64 63423292
Anaphylactoid reaction 29.44 17.12 27 65639 3696 63419660
Motion sickness 29.30 17.12 16 65650 955 63422401
Tumour necrosis 28.96 17.12 15 65651 804 63422552
Hemiparesis 28.79 17.12 70 65596 23212 63400144
Hypotension 28.68 17.12 418 65248 272186 63151170
Tumour ulceration 28.61 17.12 10 65656 198 63423158
Feeling abnormal 28.58 17.12 70 65596 148322 63275034
Influenza like illness 28.29 17.12 17 65649 66807 63356549
Treatment noncompliance 27.95 17.12 3 65663 37322 63386034
Injection site paraesthesia 27.80 17.12 13 65653 557 63422799
Cyanosis 27.79 17.12 57 65609 16878 63406478
Bursitis 27.68 17.12 3 65663 37038 63386318
Haemolytic uraemic syndrome 27.67 17.12 22 65644 2481 63420875
Adverse drug reaction 27.64 17.12 25 65641 79689 63343667
Peripheral nerve injury 27.44 17.12 12 65654 439 63422917
Intentional product use issue 27.34 17.12 57 65609 127835 63295521
Road traffic accident 27.29 17.12 3 65663 36629 63386727
Inferior vena cava stenosis 27.21 17.12 6 65660 17 63423339
Medical device site extravasation 27.03 17.12 5 65661 3 63423353
Subileus 27.00 17.12 24 65642 3155 63420201
Sedation 26.93 17.12 4 65662 38805 63384551
Urinary tract infection 26.86 17.12 162 65504 264522 63158834
Rectal cancer recurrent 26.71 17.12 6 65660 19 63423337
Hypophagia 26.67 17.12 82 65584 31177 63392179
Cytopenia 26.49 17.12 45 65621 11556 63411800
Catheter site bruise 26.46 17.12 12 65654 479 63422877
Post embolisation syndrome 26.44 17.12 5 65661 4 63423352
Left ventricular failure 26.41 17.12 31 65635 5656 63417700
K-ras gene mutation 26.25 17.12 6 65660 21 63423335
Haematemesis 26.15 17.12 80 65586 30332 63393024
Metastases to lymph nodes 26.14 17.12 37 65629 8121 63415235
Hemiparaesthesia 26.00 17.12 8 65658 104 63423252
Rhinorrhoea 25.97 17.12 18 65648 65559 63357797
Tonic clonic movements 25.94 17.12 17 65649 1418 63421938
Schistosomiasis 25.92 17.12 5 65661 5 63423351
Catabolic state 25.69 17.12 7 65659 57 63423299
White blood cell count abnormal 25.68 17.12 32 65634 6210 63417146
Granulocyte count decreased 25.66 17.12 16 65650 1224 63422132
Productive cough 25.50 17.12 17 65649 63191 63360165
Cholangitis 25.31 17.12 30 65636 5531 63417825
Disease recurrence 25.30 17.12 75 65591 27955 63395401
Balance disorder 25.29 17.12 30 65636 84392 63338964
Respiratory failure 25.13 17.12 186 65480 101672 63321684
Heart rate decreased 24.95 17.12 8 65658 45552 63377804
Ileus paralytic 24.87 17.12 27 65639 4524 63418832
Necrotic lymphadenopathy 24.78 17.12 7 65659 66 63423290
Nasal congestion 24.73 17.12 19 65647 65641 63357715
Subacute cutaneous lupus erythematosus 24.55 17.12 21 65645 2622 63420734
COVID-19 24.52 17.12 50 65616 113053 63310303
Lip oedema 24.51 17.12 25 65641 3899 63419457
Hepatocellular injury 24.46 17.12 73 65593 27308 63396048
Dizziness 24.45 17.12 306 65360 429619 62993737
Metastases to diaphragm 24.37 17.12 6 65660 31 63423325
Gastrointestinal anastomotic leak 24.21 17.12 9 65657 214 63423142
Colon cancer metastatic 24.20 17.12 15 65651 1136 63422220
Monoparesis 24.00 17.12 17 65649 1610 63421746
Administration site extravasation 23.97 17.12 14 65652 951 63422405
Sepsis 23.96 17.12 253 65413 152870 63270486
Colorectal cancer recurrent 23.89 17.12 5 65661 10 63423346
Blood glucose increased 23.80 17.12 31 65635 83725 63339631
Small intestinal obstruction 23.61 17.12 56 65610 18281 63405075
Electrolyte imbalance 23.39 17.12 59 65607 20017 63403339
Oral dysaesthesia 23.26 17.12 7 65659 84 63423272
Oesophageal varices haemorrhage 23.24 17.12 15 65651 1219 63422137
Gait inability 23.09 17.12 13 65653 52946 63370410
Colon cancer recurrent 22.89 17.12 7 65659 89 63423267
Weight decreased 22.85 17.12 180 65486 276618 63146738
Aortic intramural haematoma 22.75 17.12 7 65659 91 63423265
Portal shunt 22.72 17.12 5 65661 14 63423342
Implant site dehiscence 22.72 17.12 5 65661 14 63423342
Medication error 22.56 17.12 13 65653 52271 63371085
Myopathy toxic 22.54 17.12 11 65655 519 63422837
Diabetes mellitus 22.52 17.12 15 65651 55795 63367561
Retching 22.52 17.12 48 65618 14597 63408759
Hypocapnia 22.48 17.12 10 65656 381 63422975
Biliary tract infection 22.39 17.12 12 65654 690 63422666
Drug reaction with eosinophilia and systemic symptoms 22.33 17.12 4 65662 33832 63389524
Renal tubular disorder 22.29 17.12 20 65646 2662 63420694
Gastrointestinal stoma complication 22.01 17.12 17 65649 1838 63421518
Type II hypersensitivity 21.99 17.12 5 65661 17 63423339
Viral infection 21.90 17.12 5 65661 35658 63387698
Neutropenic infection 21.84 17.12 15 65651 1352 63422004
Gastrooesophageal reflux disease 21.83 17.12 41 65625 95598 63327758
Toxic leukoencephalopathy 21.63 17.12 12 65654 739 63422617
Swollen tongue 21.53 17.12 82 65584 34718 63388638
Soft tissue necrosis 21.47 17.12 11 65655 576 63422780
Lacrimation disorder 21.27 17.12 4 65662 3 63423353
Cardiogenic shock 21.21 17.12 53 65613 17879 63405477
Colitis ischaemic 21.18 17.12 39 65627 10669 63412687
Therapy interrupted 21.07 17.12 4 65662 32451 63390905
Coronary artery disease 20.99 17.12 4 65662 32373 63390983
Metastases to bone marrow 20.89 17.12 10 65656 452 63422904
Prescribed underdose 20.74 17.12 3 65663 29686 63393670
Growth of eyelashes 20.64 17.12 8 65658 214 63423142
Dyslalia 20.59 17.12 10 65656 467 63422889
Diarrhoea haemorrhagic 20.55 17.12 35 65631 9007 63414349
Unevaluable event 20.48 17.12 14 65652 51372 63371984
Hallucination 20.47 17.12 16 65650 54801 63368555
Eyelid ptosis 20.45 17.12 31 65635 7236 63416120
Full blood count abnormal 20.39 17.12 4 65662 31713 63391643
Respiratory fatigue 20.39 17.12 7 65659 131 63423225
Encapsulating peritoneal sclerosis 20.28 17.12 9 65657 341 63423015
Portal vein dilatation 20.28 17.12 5 65661 26 63423330
Blood phosphorus decreased 20.23 17.12 24 65642 4429 63418927
Jaw operation 20.22 17.12 12 65654 840 63422516
Paraphilia 20.12 17.12 5 65661 27 63423329
Reticulocytosis 20.10 17.12 7 65659 137 63423219
Hyperventilation 19.98 17.12 28 65638 6088 63417268
Encephalopathy 19.91 17.12 86 65580 38534 63384822
Pelvic fluid collection 19.91 17.12 12 65654 864 63422492
Neutropenic sepsis 19.88 17.12 49 65617 16389 63406967
Night sweats 19.86 17.12 13 65653 48801 63374555
Embolism 19.84 17.12 32 65634 7874 63415482
Amnesia 19.79 17.12 17 65649 55568 63367788
Hepatic cytolysis 19.78 17.12 47 65619 15360 63407996
Subclavian vein thrombosis 19.59 17.12 16 65650 1874 63421482
Hypervolaemia 19.55 17.12 3 65663 28410 63394946
Female genital tract fistula 19.53 17.12 31 65635 7528 63415828
Immune-mediated hepatitis 19.48 17.12 14 65652 1357 63421999
Hyperlipasaemia 19.47 17.12 11 65655 702 63422654
Neck pain 19.34 17.12 26 65640 69292 63354064
Loss of consciousness 19.34 17.12 197 65469 117924 63305432
Hepatic vein stenosis 19.27 17.12 5 65661 33 63423323
Dry eye 19.27 17.12 9 65657 40752 63382604
Hypoaesthesia oral 19.22 17.12 42 65624 12991 63410365
Hypothermia 19.16 17.12 43 65623 13538 63409818
Emotional distress 19.14 17.12 5 65661 32544 63390812
Splenic marginal zone lymphoma 18.89 17.12 5 65661 36 63423320
Dysentery 18.89 17.12 12 65654 949 63422407
Rhabdomyolysis 18.86 17.12 11 65655 43940 63379416
Obesity 18.80 17.12 4 65662 29948 63393408
Vasospasm 18.79 17.12 11 65655 751 63422605
Nephrolithiasis 18.75 17.12 10 65656 41974 63381382
Skin reaction 18.74 17.12 45 65621 14804 63408552
Ear pain 18.64 17.12 7 65659 36111 63387245
Altered state of consciousness 18.63 17.12 63 65603 25167 63398189
Femur fracture 18.57 17.12 10 65656 41746 63381610
Hepatic encephalopathy 18.54 17.12 38 65628 11244 63412112
Vaginal cellulitis 18.53 17.12 6 65660 93 63423263
Surgery 18.47 17.12 7 65659 35905 63387451
Toxic encephalopathy 18.42 17.12 28 65638 6551 63416805
Dyspepsia 18.30 17.12 50 65616 102146 63321210
No adverse event 18.29 17.12 10 65656 41395 63381961
Red cell fragmentation syndrome 18.22 17.12 5 65661 42 63423314
Temperature intolerance 18.17 17.12 33 65633 8931 63414425
Diaphragmatic paralysis 18.05 17.12 10 65656 614 63422742
Endometrial dysplasia 17.97 17.12 4 65662 12 63423344
Pigmentation disorder 17.85 17.12 23 65643 4616 63418740
Vascular compression 17.79 17.12 7 65659 195 63423161
Hereditary motor and sensory neuropathy 17.75 17.12 6 65660 107 63423249
Stoma site haemorrhage 17.70 17.12 12 65654 1059 63422297
Blood fibrinogen decreased 17.64 17.12 11 65655 842 63422514
Appendicitis noninfective 17.63 17.12 3 65663 0 63423356
Cognitive disorder 17.63 17.12 19 65647 55796 63367560
Femoral artery embolism 17.62 17.12 5 65661 48 63423308
Acute respiratory distress syndrome 17.59 17.12 59 65607 23475 63399881
Aortitis 17.54 17.12 12 65654 1075 63422281
Aortic thrombosis 17.42 17.12 12 65654 1087 63422269
Full blood count decreased 17.34 17.12 3 65663 26021 63397335
Hyperbilirubinaemia 17.30 17.12 37 65629 11277 63412079

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuropathy peripheral 1440.08 15.10 1401 89444 81862 34784224
Disease progression 1133.46 15.10 1398 89447 106679 34759407
Neurotoxicity 784.96 15.10 522 90323 17488 34848598
Diarrhoea 676.89 15.10 2381 88464 387531 34478555
Neutropenia 617.84 15.10 1298 89547 155480 34710606
Dermatitis acneiform 603.12 15.10 303 90542 5886 34860200
Skin toxicity 598.65 15.10 278 90567 4506 34861580
Arteriospasm coronary 576.07 15.10 244 90601 3138 34862948
Palmar-plantar erythrodysaesthesia syndrome 570.83 15.10 418 90427 16377 34849709
Thrombocytopenia 530.77 15.10 1219 89626 155028 34711058
Metastases to liver 386.84 15.10 305 90540 13358 34852728
Paronychia 386.43 15.10 185 90660 3220 34862866
Myelosuppression 381.17 15.10 350 90495 18915 34847171
Polyneuropathy 369.89 15.10 308 90537 14588 34851498
Peripheral sensory neuropathy 366.56 15.10 225 90620 6535 34859551
Erythema 354.59 15.10 740 90105 88040 34778046
Vomiting 351.56 15.10 1421 89424 246200 34619886
Interstitial lung disease 328.58 15.10 600 90245 64682 34801404
Venoocclusive liver disease 292.82 15.10 208 90637 7758 34858328
Nausea 290.77 15.10 1686 89159 338222 34527864
Paraesthesia 287.18 15.10 561 90284 63611 34802475
Mucosal inflammation 272.13 15.10 413 90432 38209 34827877
Portal hypertension 272.11 15.10 155 90690 3907 34862179
Product dose omission issue 270.72 15.10 9 90836 119702 34746384
Chills 263.13 15.10 622 90223 80421 34785665
Hypersensitivity 256.76 15.10 520 90325 60515 34805571
Haematotoxicity 256.09 15.10 194 90651 8000 34858086
Gastrointestinal toxicity 249.93 15.10 128 90717 2591 34863495
Completed suicide 239.14 15.10 3 90842 98165 34767921
Gastrointestinal perforation 228.57 15.10 136 90709 3727 34862359
Bone marrow failure 227.91 15.10 328 90517 28925 34837161
Arthralgia 225.90 15.10 80 90765 169961 34696125
Enteritis 218.13 15.10 176 90669 7966 34858120
Stomatitis 212.81 15.10 390 90455 42124 34823962
Metastases to lung 197.41 15.10 176 90669 9144 34856942
Drug interaction 181.42 15.10 192 90653 225754 34640332
Drug ineffective 178.87 15.10 601 90244 456150 34409936
Fall 173.64 15.10 163 90682 202722 34663364
Cardiotoxicity 172.69 15.10 132 90713 5516 34860570
Laryngospasm 167.61 15.10 81 90764 1440 34864646
Headache 166.11 15.10 166 90679 200469 34665617
Flushing 165.50 15.10 300 90545 32120 34833966
Overdose 157.97 15.10 24 90821 91035 34775051
Focal nodular hyperplasia 156.10 15.10 43 90802 120 34865966
Bronchospasm 154.55 15.10 164 90681 10567 34855519
Decreased appetite 154.47 15.10 845 90000 165547 34700539
Malignant neoplasm progression 152.17 15.10 539 90306 87507 34778579
Therapy partial responder 151.13 15.10 154 90691 9462 34856624
Pneumonia 145.95 15.10 471 90374 362156 34503930
Carcinoembryonic antigen increased 144.24 15.10 58 90787 647 34865439
Hypomagnesaemia 143.11 15.10 226 90619 21625 34844461
Hyperammonaemic encephalopathy 140.58 15.10 83 90762 2241 34863845
Neoplasm progression 139.00 15.10 231 90614 23069 34843017
Abdominal pain 133.53 15.10 803 90042 162815 34703271
Dysaesthesia pharynx 127.46 15.10 30 90815 31 34866055
Hyperammonaemia 124.56 15.10 115 90730 6252 34859834
Tumour perforation 118.54 15.10 41 90804 288 34865798
Proteinuria 118.21 15.10 190 90655 18452 34847634
Enterocolitis 117.95 15.10 124 90721 7902 34858184
Cardiac failure congestive 117.82 15.10 35 90810 83235 34782851
Metastases to peritoneum 117.19 15.10 68 90777 1776 34864310
Leukopenia 116.55 15.10 394 90451 62462 34803624
Skin reaction 115.21 15.10 101 90744 5129 34860957
Anastomotic leak 112.36 15.10 47 90798 584 34865502
Infusion related reaction 110.45 15.10 346 90499 52711 34813375
Pyrexia 110.33 15.10 1335 89510 331678 34534408
Feeling hot 108.84 15.10 187 90658 19185 34846901
Insomnia 108.48 15.10 68 90777 103839 34762247
Hospitalisation 108.40 15.10 11 90834 56891 34809195
Depression 107.80 15.10 59 90786 97039 34769047
Neutrophil count decreased 107.06 15.10 334 90511 50770 34815316
Oxygen saturation decreased 104.79 15.10 343 90502 53475 34812611
Dehydration 103.48 15.10 634 90211 129335 34736751
Joint swelling 101.10 15.10 17 90828 59873 34806213
Intestinal obstruction 100.11 15.10 198 90647 22624 34843462
Toxic leukoencephalopathy 99.25 15.10 38 90807 368 34865718
Pneumatosis intestinalis 99.18 15.10 82 90763 3841 34862245
Intravascular haemolysis 97.63 15.10 39 90806 427 34865659
Stomal varices 97.30 15.10 26 90819 62 34866024
Anxiety 97.17 15.10 70 90775 99358 34766728
Weight increased 96.95 15.10 61 90784 92972 34773114
Peripheral swelling 96.51 15.10 39 90806 76502 34789584
Myalgia 96.47 15.10 49 90796 84061 34782025
Ascites 96.28 15.10 303 90542 46268 34819818
Varices oesophageal 93.91 15.10 78 90767 3677 34862409
Anaphylactic shock 93.67 15.10 157 90688 15784 34850302
Inappropriate schedule of product administration 90.30 15.10 25 90820 62271 34803815
Tumour necrosis 88.55 15.10 50 90795 1238 34864848
Influenza 86.30 15.10 13 90832 49653 34816433
Rhabdomyolysis 85.50 15.10 35 90810 68128 34797958
Aggression 84.39 15.10 4 90841 38960 34827126
Somnolence 83.99 15.10 99 90746 111017 34755069
Laryngeal discomfort 82.68 15.10 28 90817 183 34865903
Rheumatoid arthritis 82.57 15.10 4 90841 38234 34827852
Anastomotic complication 81.75 15.10 33 90812 372 34865714
Type I hypersensitivity 81.45 15.10 48 90797 1291 34864795
Rash pustular 80.27 15.10 84 90761 5324 34860762
Pain in extremity 80.25 15.10 128 90717 126385 34739701
Injection site pain 78.45 15.10 6 90839 38999 34827087
Hallucination 77.81 15.10 19 90826 51479 34814607
Febrile neutropenia 77.30 15.10 614 90231 136235 34729851
Ileus 75.83 15.10 146 90699 16353 34849733
Non-cirrhotic portal hypertension 75.33 15.10 28 90817 248 34865838
Dihydropyrimidine dehydrogenase deficiency 74.63 15.10 21 90824 65 34866021
Colorectal cancer metastatic 74.34 15.10 37 90808 703 34865383
Incorrect dose administered 74.21 15.10 9 90836 40506 34825580
Diffuse large B-cell lymphoma recurrent 72.43 15.10 63 90782 3165 34862921
Suicidal ideation 71.50 15.10 10 90835 40378 34825708
Metastases to lymph nodes 71.18 15.10 74 90771 4654 34861432
Extravasation 70.94 15.10 50 90795 1840 34864246
Death 70.29 15.10 679 90166 397370 34468716
Peritonitis 69.39 15.10 140 90705 16225 34849861
Contusion 69.33 15.10 7 90838 36357 34829729
Hyperhidrosis 69.10 15.10 383 90462 75309 34790777
Myocardial infarction 68.18 15.10 132 90713 120953 34745133
Portal shunt 68.15 15.10 17 90828 27 34866059
Asthma 67.94 15.10 14 90831 42642 34823444
Blood glucose increased 67.78 15.10 45 90800 66673 34799413
Rectal perforation 66.66 15.10 30 90815 450 34865636
Foetal exposure during pregnancy 66.13 15.10 10 90835 38091 34827995
Splenomegaly 66.10 15.10 131 90714 14986 34851100
Large intestine perforation 65.68 15.10 95 90750 8408 34857678
Confusional state 65.14 15.10 177 90668 143983 34722103
Vascular pain 64.42 15.10 22 90823 148 34865938
Hypertransaminasaemia 64.13 15.10 76 90769 5530 34860556
Disseminated intravascular coagulation 63.79 15.10 161 90684 21655 34844431
Toxicity to various agents 63.64 15.10 286 90559 200076 34666010
Memory impairment 63.49 15.10 17 90828 43301 34822785
Hepatic atrophy 62.83 15.10 22 90823 161 34865925
Electrocardiogram ST segment elevation 61.56 15.10 72 90773 5166 34860920
Nasopharyngitis 61.15 15.10 55 90790 69913 34796173
Agitation 60.65 15.10 37 90808 57362 34808724
Arthritis 59.84 15.10 6 90839 31340 34834746
Product use issue 59.81 15.10 46 90799 63170 34802916
Coronary artery disease 58.65 15.10 26 90819 48279 34817807
Tumour lysis syndrome 58.60 15.10 134 90711 16925 34849161
Therapeutic product effect decreased 58.32 15.10 10 90835 34733 34831353
Colon cancer metastatic 58.20 15.10 42 90803 1605 34864481
Palmar erythema 58.20 15.10 24 90821 287 34865799
Dysphonia 57.67 15.10 162 90683 23221 34842865
Feeling abnormal 57.33 15.10 48 90797 63187 34802899
Temperature intolerance 55.95 15.10 56 90789 3366 34862720
Hyperthermia 55.37 15.10 99 90746 10478 34855608
Pain 54.81 15.10 310 90535 204365 34661721
Electrocardiogram QT prolonged 54.73 15.10 19 90826 40933 34825153
Intestinal perforation 54.25 15.10 90 90755 8970 34857116
Chronic obstructive pulmonary disease 53.86 15.10 30 90815 48888 34817198
Necrotising fasciitis 53.79 15.10 57 90788 3665 34862421
Dysaesthesia 53.77 15.10 46 90799 2259 34863827
Asthenia 53.65 15.10 915 89930 244336 34621750
Paraesthesia oral 53.22 15.10 60 90785 4137 34861949
Cholangitis 52.95 15.10 87 90758 8602 34857484
Cholinergic syndrome 52.11 15.10 27 90818 560 34865526
Irritability 52.00 15.10 3 90842 24687 34841399
Nodular regenerative hyperplasia 51.75 15.10 32 90813 941 34865145
Musculoskeletal stiffness 50.86 15.10 29 90816 46651 34819435
Drug dependence 50.82 15.10 3 90842 24214 34841872
Sinusitis 50.71 15.10 22 90823 41380 34824706
Subileus 49.78 15.10 51 90794 3152 34862934
Hiccups 49.78 15.10 92 90753 9990 34856096
Cellulitis 49.49 15.10 39 90806 52912 34813174
Unevaluable event 49.27 15.10 12 90833 32578 34833508
Stoma site haemorrhage 49.20 15.10 30 90815 860 34865226
Administration site extravasation 48.52 15.10 26 90819 579 34865507
General physical health deterioration 48.39 15.10 528 90317 127741 34738345
Treatment noncompliance 47.36 15.10 8 90837 28092 34837994
Dizziness 47.31 15.10 353 90492 218168 34647918
Recall phenomenon 47.09 15.10 25 90820 546 34865540
Malignant ascites 46.69 15.10 23 90822 427 34865659
Neutropenic sepsis 46.03 15.10 107 90738 13660 34852426
Drug level increased 45.58 15.10 3 90842 22093 34843993
Perforation 45.36 15.10 19 90826 237 34865849
Blood pressure fluctuation 45.28 15.10 6 90839 25243 34840843
Mucosal toxicity 45 15.10 19 90826 242 34865844
Transdifferentiation of neoplasm 44.97 15.10 14 90831 67 34866019
Cyanosis 44.66 15.10 101 90744 12663 34853423
Abdominal discomfort 44.44 15.10 54 90791 59781 34806305
Pulmonary embolism 44.39 15.10 391 90454 89355 34776731
Folliculitis 44.33 15.10 57 90788 4509 34861577
Condition aggravated 44.24 15.10 305 90540 191891 34674195
Gastrointestinal anastomotic leak 44.01 15.10 22 90823 422 34865664
Enterovesical fistula 43.97 15.10 27 90818 784 34865302
Off label use 43.71 15.10 1411 89434 418113 34447973
Wound dehiscence 43.12 15.10 48 90797 3263 34862823
Septic shock 43.09 15.10 327 90518 71507 34794579
Prinzmetal angina 43.06 15.10 29 90816 990 34865096
Anastomotic fistula 42.92 15.10 14 90831 80 34866006
Wrong technique in product usage process 42.70 15.10 20 90825 35966 34830120
Splenorenal shunt 42.65 15.10 10 90835 10 34866076
Abnormal behaviour 42.32 15.10 7 90838 24962 34841124
Intestinal ischaemia 42.15 15.10 74 90771 7720 34858366
Hypertensive crisis 42.13 15.10 79 90766 8672 34857414
Blood alkaline phosphatase abnormal 42.13 15.10 22 90823 464 34865622
Immune thrombocytopenia 42.06 15.10 81 90764 9071 34857015
Hypokalaemia 41.92 15.10 277 90568 57937 34808149
Chronic kidney disease 41.57 15.10 28 90817 41182 34824904
Psychotic disorder 41.12 15.10 7 90838 24445 34841641
Portal vein thrombosis 41.11 15.10 50 90795 3738 34862348
Evans syndrome 41.11 15.10 18 90827 252 34865834
Anaphylactic reaction 40.54 15.10 179 90666 32122 34833964
Fluid retention 40.45 15.10 10 90835 26877 34839209
Noninfective epididymitis 39.64 15.10 8 90837 0 34866086
Oxygen saturation normal 39.64 15.10 8 90837 0 34866086
Premature baby 39.53 15.10 3 90842 19630 34846456
Pulmonary toxicity 39.43 15.10 63 90782 6084 34860002
International normalised ratio increased 39.24 15.10 39 90806 47288 34818798
Contraindicated product administered 38.78 15.10 5 90840 21476 34844610
Large intestinal obstruction 38.62 15.10 32 90813 1503 34864583
Throat tightness 38.45 15.10 74 90771 8284 34857802
Blood creatine phosphokinase increased 38.31 15.10 36 90809 44821 34821265
Drug reaction with eosinophilia and systemic symptoms 38.17 15.10 19 90826 32993 34833093
Gastric perforation 37.14 15.10 39 90806 2481 34863605
Hypercreatinaemia 37.01 15.10 15 90830 171 34865915
Small intestinal obstruction 36.66 15.10 103 90742 14763 34851323
Influenza like illness 36.62 15.10 13 90832 27621 34838465
Blood cholesterol increased 36.56 15.10 5 90840 20538 34845548
Acute coronary syndrome 36.55 15.10 97 90748 13448 34852638
Nicotinic acid deficiency 36.24 15.10 13 90832 103 34865983
Diabetes mellitus 36.20 15.10 41 90804 46832 34819254
Prostate cancer 36.05 15.10 30 90815 39619 34826467
Blood pressure immeasurable 36.00 15.10 25 90820 898 34865188
Blood pressure systolic increased 35.59 15.10 8 90837 22944 34843142
Type II hypersensitivity 35.52 15.10 10 90835 31 34866055
Bronchitis 35.46 15.10 34 90811 41929 34824157
Leukoencephalopathy 35.37 15.10 49 90796 4166 34861920
Cardiac disorder 35.22 15.10 36 90809 43090 34822996
Herpes zoster 35.20 15.10 23 90822 34376 34831710
Pseudocirrhosis 35.10 15.10 9 90836 17 34866069
Drug withdrawal syndrome 34.89 15.10 5 90840 19829 34846257
Portal venous gas 34.84 15.10 18 90827 371 34865715
Oesophagitis 34.80 15.10 94 90751 13167 34852919
Hepatic infarction 34.65 15.10 15 90830 204 34865882
Hypervolaemia 34.60 15.10 5 90840 19704 34846382
Hyperkalaemia 34.56 15.10 81 90764 69308 34796778
Localised infection 34.54 15.10 3 90842 17584 34848502
Medication error 33.92 15.10 12 90833 25553 34840533
Swelling 33.89 15.10 36 90809 42330 34823756
Acute abdomen 33.83 15.10 33 90812 1922 34864164
Cytokine release syndrome 33.57 15.10 133 90712 22744 34843342
Stridor 33.46 15.10 37 90808 2497 34863589
Cytomegalovirus infection 33.44 15.10 13 90832 26122 34839964
Tumour marker increased 33.35 15.10 21 90824 638 34865448
Hyperbilirubinaemia 33.34 15.10 108 90737 16735 34849351
Sedation 33.23 15.10 7 90838 20999 34845087
Papilloedema 33.07 15.10 38 90807 2675 34863411
Amaurosis fugax 33.03 15.10 20 90825 566 34865520
Liver function test abnormal 32.86 15.10 20 90825 31054 34835032
Small intestinal perforation 32.72 15.10 34 90811 2137 34863949
Upper respiratory tract infection 32.62 15.10 23 90822 33036 34833050
Type III immune complex mediated reaction 32.58 15.10 16 90829 295 34865791
Seizure 32.44 15.10 151 90694 104706 34761380
Mobility decreased 32.41 15.10 19 90826 30109 34835977
Oesophageal haemorrhage 32.18 15.10 27 90818 1291 34864795
Performance status decreased 31.63 15.10 46 90799 4091 34861995
Metastasis 31.57 15.10 46 90799 4098 34861988
Productive cough 31.53 15.10 31 90814 37782 34828304
Carbohydrate antigen 19-9 increased 31.35 15.10 14 90831 206 34865880
Cerebrovascular accident 31.31 15.10 114 90731 84697 34781389
Accidental overdose 31.27 15.10 7 90838 20133 34845953
Pelvic abscess 31.04 15.10 23 90822 916 34865170
Head injury 30.98 15.10 5 90840 18155 34847931
Haemoglobin abnormal 30.92 15.10 44 90801 3836 34862250
Haematoma 30.73 15.10 14 90831 25591 34840495
Encapsulating peritoneal sclerosis 30.39 15.10 19 90826 570 34865516
Adenocarcinoma 30.35 15.10 31 90814 1909 34864177
Ocular toxicity 30.29 15.10 14 90831 224 34865862
Nasal congestion 30.29 15.10 11 90834 23046 34843040
Sleep disorder 30.03 15.10 23 90822 31665 34834421
Dyspnoea 29.81 15.10 1229 89616 375553 34490533
ECG signs of myocardial ischaemia 29.56 15.10 13 90832 184 34865902
Liver abscess 29.33 15.10 43 90802 3852 34862234
Hepatectomy 29.32 15.10 10 90835 67 34866019
Hypovolaemic shock 29.30 15.10 60 90785 7025 34859061
Sciatic nerve palsy 29.27 15.10 9 90836 41 34866045
Haemolytic anaemia 29.25 15.10 76 90769 10403 34855683
Perforation bile duct 29.13 15.10 8 90837 22 34866064
Circulatory collapse 29.03 15.10 120 90725 20918 34845168
Eosinophilia 28.98 15.10 16 90829 26206 34839880
Lymphangiosis carcinomatosa 28.97 15.10 22 90823 910 34865176
Muscular weakness 28.92 15.10 95 90750 72802 34793284
Trismus 28.83 15.10 34 90811 2461 34863625
Nephrolithiasis 28.77 15.10 22 90823 30311 34835775
Gene mutation 28.65 15.10 26 90819 1382 34864704
Rectal cancer metastatic 28.59 15.10 13 90832 200 34865886
Erectile dysfunction 28.58 15.10 9 90836 20628 34845458
Oesophageal varices haemorrhage 28.56 15.10 38 90807 3108 34862978
Failure to anastomose 28.47 15.10 13 90832 202 34865884
Device related infection 28.41 15.10 104 90741 17133 34848953
Emotional distress 28.36 15.10 3 90842 15023 34851063
Laryngeal oedema 28.27 15.10 40 90805 3468 34862618
Acute respiratory distress syndrome 28.23 15.10 138 90707 25831 34840255
Adverse drug reaction 28.19 15.10 21 90824 29321 34836765
Liver injury 28.19 15.10 94 90751 14784 34851302
Peripheral sensorimotor neuropathy 27.93 15.10 27 90818 1555 34864531
Hypoalbuminaemia 27.75 15.10 82 90763 12092 34853994
Cachexia 27.56 15.10 59 90786 7127 34858959
Delirium 27.39 15.10 45 90800 43946 34822140
Anaphylactoid reaction 27.39 15.10 32 90813 2293 34863793
Rectosigmoid cancer 27.34 15.10 12 90833 169 34865917
Biliary fistula 27.23 15.10 9 90836 54 34866032
Right ventricular ejection fraction decreased 27.23 15.10 9 90836 54 34866032
Road traffic accident 27.22 15.10 6 90839 17444 34848642
Haemoglobinuria 27.19 15.10 18 90827 597 34865489
Anal sphincter atony 27.06 15.10 10 90835 87 34865999
Brain teratoma 27.03 15.10 7 90838 14 34866072
Pulmonary oedema 26.56 15.10 52 90793 47477 34818609
Basal cell carcinoma 26.47 15.10 9 90836 19649 34846437
Subdural haematoma 26.39 15.10 10 90835 20411 34845675
Osteomyelitis 26.31 15.10 5 90840 16131 34849955
Hepatocellular injury 26.30 15.10 121 90724 22090 34843996
Hypoglycaemia 26.24 15.10 65 90780 54575 34811511
Pulmonary fibrosis 26.23 15.10 106 90739 18290 34847796
Oedema peripheral 26.14 15.10 193 90652 119619 34746467
Vocal cord paralysis 26.12 15.10 21 90824 945 34865141
Renal disorder 26.12 15.10 17 90828 25463 34840623
Wheezing 26.11 15.10 42 90803 41360 34824726
Full blood count abnormal 26.10 15.10 8 90837 18660 34847426
Necrotising oesophagitis 26.08 15.10 17 90828 549 34865537
Haemorrhage intracranial 25.87 15.10 5 90840 15941 34850145
Ileal perforation 25.86 15.10 19 90826 747 34865339
Labelled drug-drug interaction medication error 25.74 15.10 4 90841 14935 34851151
Aortic thrombosis 25.59 15.10 19 90826 759 34865327
Gait disturbance 25.51 15.10 124 90721 85016 34781070
Blood pressure increased 25.43 15.10 130 90715 87972 34778114
Gastrointestinal obstruction 25.32 15.10 20 90825 877 34865209
Hyperaemia 25.29 15.10 23 90822 1226 34864860
Blood creatinine increased 25.29 15.10 144 90701 94832 34771254
Embolism 25.24 15.10 60 90785 7769 34858317
Pruritus 24.82 15.10 512 90333 141469 34724617
Hepatic failure 24.66 15.10 164 90681 34367 34831719
Loss of personal independence in daily activities 24.57 15.10 30 90815 33149 34832937
Cold sweat 24.43 15.10 69 90776 9918 34856168
Hyperpyrexia 24.28 15.10 33 90812 2755 34863331
Heart rate decreased 24.26 15.10 28 90817 31717 34834369
Periportal sinus dilatation 24.03 15.10 11 90834 172 34865914
Gout 23.94 15.10 10 90835 19243 34846843
Oesophagobronchial fistula 23.86 15.10 11 90834 175 34865911
Biliary tract infection 23.83 15.10 17 90828 638 34865448
Injection site erythema 23.75 15.10 6 90839 15893 34850193
Cataract 23.57 15.10 20 90825 26166 34839920
Koebner phenomenon 23.53 15.10 8 90837 53 34866033
Laboratory test abnormal 23.18 15.10 12 90833 20379 34845707
Cardiac ventricular disorder 23.16 15.10 12 90833 249 34865837
Diffuse large B-cell lymphoma refractory 23.10 15.10 22 90823 1244 34864842
Lower respiratory tract infection 23.01 15.10 29 90816 31608 34834478
Wound infection 22.55 15.10 54 90791 7025 34859061
Thrombotic thrombocytopenic purpura 22.25 15.10 35 90810 3335 34862751
Withdrawal syndrome 22.24 15.10 3 90842 12452 34853634
Respiratory arrest 22.23 15.10 24 90821 28019 34838067
Aortitis 22.21 15.10 14 90831 426 34865660
Tachycardia 22.12 15.10 326 90519 84446 34781640
Blood lactate dehydrogenase increased 22.07 15.10 118 90727 22872 34843214
Throat irritation 21.97 15.10 69 90776 10516 34855570
Fingerprint loss 21.92 15.10 7 90838 37 34866049
Adenocarcinoma metastatic 21.92 15.10 7 90838 37 34866049
Haematemesis 21.87 15.10 135 90710 27576 34838510
Pulmonary artery thrombosis 21.81 15.10 17 90828 731 34865355
Astringent therapy 21.71 15.10 6 90839 17 34866069
Poisoning 21.70 15.10 3 90842 12223 34853863
Angioedema 21.66 15.10 40 90805 37334 34828752
Band sensation 21.65 15.10 9 90836 110 34865976
Pachymeningitis 21.57 15.10 9 90836 111 34865975
Full blood count decreased 21.54 15.10 10 90835 18078 34848008
Pelvic fluid collection 21.47 15.10 10 90835 163 34865923
Nephrotic syndrome 21.45 15.10 54 90791 7249 34858837
Balance disorder 21.42 15.10 46 90799 40608 34825478
Pulmonary hypertension 21.39 15.10 14 90831 20910 34845176
Onycholysis 21.34 15.10 17 90828 755 34865331
Hyperfibrinolysis 21.22 15.10 6 90839 19 34866067
Obstruction gastric 21.19 15.10 19 90826 994 34865092
Perihepatic abscess 21.15 15.10 9 90836 117 34865969
Cholestasis 21.09 15.10 131 90714 26817 34839269
Hepatic lesion 21.06 15.10 36 90809 3676 34862410
Fistula of small intestine 21.05 15.10 14 90831 468 34865618
Obstructive airways disorder 21.02 15.10 7 90838 15487 34850599
Metastases to muscle 20.98 15.10 11 90834 234 34865852
Muscle contractions involuntary 20.96 15.10 25 90820 1831 34864255
Monocytopenia 20.94 15.10 8 90837 77 34866009
Cerebral vasoconstriction 20.73 15.10 11 90834 240 34865846
Hypotension 20.55 15.10 736 90109 220913 34645173
Interventricular septum rupture 20.55 15.10 6 90839 22 34866064
Metastases to retroperitoneum 20.53 15.10 11 90834 245 34865841
Gastrointestinal mucosal necrosis 20.48 15.10 10 90835 182 34865904
Xerosis 20.43 15.10 15 90830 589 34865497
Intentional product use issue 20.40 15.10 83 90762 59733 34806353
Acral peeling skin syndrome 20.26 15.10 7 90838 49 34866037
Vascular access complication 20.09 15.10 12 90833 331 34865755
Product prescribing error 20.05 15.10 18 90827 22909 34843177
Skin fissures 19.96 15.10 43 90802 5216 34860870
Mucocutaneous rash 19.94 15.10 6 90839 25 34866061
Blood triglycerides increased 19.92 15.10 6 90839 14153 34851933
Gastric dilatation 19.92 15.10 16 90829 719 34865367
Hypersomnia 19.90 15.10 4 90841 12403 34853683
Induration 19.83 15.10 18 90827 957 34865129
Peripheral nerve injury 19.76 15.10 10 90835 197 34865889
Metastases to bone marrow 19.65 15.10 14 90831 524 34865562
Portal vein dilatation 19.65 15.10 5 90840 9 34866077
Hot flush 19.63 15.10 96 90749 17970 34848116
Jaundice 19.59 15.10 146 90699 31736 34834350
Hypophagia 19.57 15.10 118 90727 23904 34842182
Catheter site extravasation 19.52 15.10 8 90837 94 34865992
Product administration error 19.52 15.10 9 90836 16335 34849751
Intestinal dilatation 19.47 15.10 20 90825 1240 34864846
Alopecia 19.44 15.10 119 90726 24236 34841850
Choking sensation 19.43 15.10 19 90826 1110 34864976
COVID-19 19.36 15.10 120 90725 77430 34788656
Respiratory depression 19.31 15.10 9 90836 16236 34849850
Ischiorectal hernia 19.31 15.10 5 90840 10 34866076
Hand-foot-genital syndrome 19.31 15.10 5 90840 10 34866076
Rhinorrhoea 19.23 15.10 23 90822 25645 34840441
Sarcoidosis 19.08 15.10 30 90815 2858 34863228
Diaphragmatic operation 19.06 15.10 6 90839 30 34866056
Therapy interrupted 18.92 15.10 6 90839 13691 34852395
Chronic myeloid leukaemia 18.88 15.10 26 90819 2198 34863888
Peritoneal haematoma 18.83 15.10 7 90838 62 34866024
Peritoneal lesion 18.80 15.10 8 90837 104 34865982
Adverse event 18.80 15.10 13 90832 18864 34847222
Oropharyngeal spasm 18.72 15.10 9 90836 158 34865928
Anger 18.71 15.10 4 90841 11880 34854206
Cytopenia 18.69 15.10 74 90771 12649 34853437
Neoplasm recurrence 18.65 15.10 26 90819 2223 34863863
Loss of consciousness 18.56 15.10 310 90535 82357 34783729
Ventricular dysfunction 18.48 15.10 35 90810 3870 34862216
Heart rate irregular 18.42 15.10 9 90836 15798 34850288
Appendicitis noninfective 18.41 15.10 5 90840 13 34866073
Limb injury 18.27 15.10 4 90841 11685 34854401
Disease susceptibility 18.26 15.10 7 90838 68 34866018
Transient aphasia 18.26 15.10 12 90833 393 34865693
Skin laceration 18.15 15.10 5 90840 12504 34853582
Perineal disorder 18.08 15.10 7 90838 70 34866016
Colon cancer recurrent 18.08 15.10 8 90837 115 34865971
Stomal hernia 17.99 15.10 10 90835 240 34865846
Pneumatosis 17.92 15.10 13 90832 501 34865585
Chemical peritonitis 17.83 15.10 8 90837 119 34865967
Viral infection 17.73 15.10 12 90833 17611 34848475
Peripheral ischaemia 17.71 15.10 43 90802 5644 34860442
Pulmonary infarction 17.63 15.10 20 90825 1388 34864698
Abdominal pain lower 17.61 15.10 64 90781 10507 34855579
Neurosarcoidosis 17.53 15.10 9 90836 183 34865903
Platelet count decreased 17.52 15.10 421 90424 119296 34746790
Pneumonitis chemical 17.44 15.10 9 90836 185 34865901
Perineal ulceration 17.41 15.10 5 90840 17 34866069
Underdose 17.39 15.10 7 90838 13773 34852313
Blindness transient 17.38 15.10 25 90820 2201 34863885
Feeling cold 17.37 15.10 64 90781 10575 34855511
Shock 17.36 15.10 115 90730 24064 34842022
Sinus bradycardia 17.34 15.10 6 90839 12957 34853129
Mental impairment 17.26 15.10 3 90842 10319 34855767
Device related thrombosis 17.25 15.10 18 90827 1137 34864949
Conjunctivitis 17.23 15.10 60 90785 9645 34856441
Hypoxia 17.23 15.10 79 90766 55016 34811070
Acute motor-sensory axonal neuropathy 17.20 15.10 8 90837 130 34865956
Hypersplenism 17.16 15.10 12 90833 436 34865650
Intrahepatic portal hepatic venous fistula 17.06 15.10 4 90841 4 34866082
Nephritis allergic 17.04 15.10 12 90833 441 34865645
Abdominal sepsis 17.04 15.10 17 90828 1018 34865068
Malaise 16.95 15.10 616 90229 185209 34680877
Gastrointestinal stoma complication 16.93 15.10 19 90826 1303 34864783
Microangiopathic haemolytic anaemia 16.93 15.10 16 90829 896 34865190
Blood potassium increased 16.91 15.10 11 90834 16484 34849602
Dyskinesia 16.88 15.10 20 90825 22393 34843693
VIth nerve disorder 16.78 15.10 5 90840 20 34866066
Metastases to spleen 16.66 15.10 12 90833 457 34865629
Peritoneal disorder 16.64 15.10 10 90835 279 34865807
Oral dysaesthesia 16.59 15.10 7 90838 89 34865997
Thyroglobulin increased 16.59 15.10 5 90840 21 34866065
Vascular injury 16.58 15.10 10 90835 281 34865805
Gastrointestinal necrosis 16.56 15.10 31 90814 3398 34862688
Venoocclusive disease 16.52 15.10 28 90817 2839 34863247
Peripheral motor neuropathy 16.49 15.10 22 90823 1804 34864282
Bronchostenosis 16.48 15.10 10 90835 284 34865802
Tooth disorder 16.46 15.10 4 90841 10878 34855208
Bacterial colitis 16.36 15.10 6 90839 51 34866035
Blood bilirubin decreased 16.32 15.10 11 90834 376 34865710
Retroperitoneal mass 16.31 15.10 7 90838 93 34865993
Blood glucose decreased 16.26 15.10 7 90838 13230 34852856
Allodynia 16.23 15.10 15 90830 816 34865270
Skin disorder 16.16 15.10 74 90771 13481 34852605
Adenovirus reactivation 16.15 15.10 9 90836 217 34865869
Vascular access site occlusion 16.06 15.10 6 90839 54 34866032
Device issue 16.00 15.10 3 90842 9774 34856312
Electromyogram abnormal 15.96 15.10 6 90839 55 34866031
Hypoaesthesia 15.91 15.10 236 90609 61208 34804878
Squamous cell carcinoma 15.90 15.10 5 90840 11470 34854616
Oesophageal carcinoma recurrent 15.88 15.10 5 90840 25 34866061
Eczema impetiginous 15.88 15.10 5 90840 25 34866061
Radiation interaction 15.88 15.10 5 90840 25 34866061
Stevens-Johnson syndrome 15.86 15.10 15 90830 18624 34847462
Coma 15.81 15.10 63 90782 45615 34820471
Rectal obstruction 15.79 15.10 4 90841 7 34866079
Metastases to pelvis 15.79 15.10 10 90835 307 34865779
Mental disorder 15.79 15.10 10 90835 15199 34850887
Urinary tract infection 15.77 15.10 141 90704 83940 34782146
Nail disorder 15.72 15.10 23 90822 2056 34864030
Trichomegaly 15.72 15.10 5 90840 26 34866060
Abdominal mass 15.63 15.10 19 90826 1420 34864666
Hepatic cancer recurrent 15.62 15.10 10 90835 313 34865773
Ichthyosis 15.61 15.10 7 90838 104 34865982
Toxic epidermal necrolysis 15.58 15.10 20 90825 21626 34844460
Eczema 15.50 15.10 15 90830 18421 34847665
Platelet count increased 15.43 15.10 3 90842 9523 34856563
Volvulus of small bowel 15.33 15.10 6 90839 62 34866024
Pneumoperitoneum 15.31 15.10 21 90824 1769 34864317
Duodenal stenosis 15.27 15.10 9 90836 242 34865844
Hypoacusis 15.23 15.10 12 90833 16289 34849797
Pancreatitis 15.20 15.10 51 90794 38840 34827246
Faeces discoloured 15.15 15.10 10 90835 14868 34851218
Surgery 15.12 15.10 9 90836 14148 34851938

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuropathy peripheral 2916.44 15.18 2226 138058 139079 79465025
Disease progression 2079.77 15.18 2058 138226 182304 79421800
Neutropenia 1620.80 15.18 2248 138036 285462 79318642
Neurotoxicity 1535.80 15.18 862 139422 31656 79572448
Thrombocytopenia 1281.53 15.18 1928 138356 263331 79340773
Diarrhoea 1083.99 15.18 3696 136588 876793 78727311
Palmar-plantar erythrodysaesthesia syndrome 969.82 15.18 647 139637 32487 79571617
Laryngospasm 966.77 15.18 335 139949 3662 79600442
Dermatitis acneiform 953.33 15.18 427 139857 9566 79594538
Arteriospasm coronary 872.04 15.18 357 139927 6359 79597745
Skin toxicity 840.44 15.18 370 139914 7944 79596160
Myelosuppression 753.39 15.18 600 139684 39696 79564408
Paraesthesia 713.53 15.18 1183 139101 175140 79428964
Polyneuropathy 659.84 15.18 452 139832 23699 79580405
Peripheral sensory neuropathy 651.94 15.18 359 139925 12674 79591430
Mucosal inflammation 635.51 15.18 723 139561 74857 79529247
Arthralgia 582.70 15.18 145 140139 571658 79032446
Vomiting 582.34 15.18 2512 137772 663316 78940788
Metastases to liver 542.92 15.18 428 139856 27886 79576218
Bone marrow failure 518.74 15.18 540 139744 50567 79553537
Venoocclusive liver disease 504.33 15.18 293 139991 11478 79592626
Paronychia 503.87 15.18 255 140029 7553 79596551
Erythema 484.52 15.18 1154 139130 222136 79381968
Nausea 428.58 15.18 3010 137274 954186 78649918
Interstitial lung disease 414.75 15.18 725 139559 111875 79492229
Bronchospasm 411.65 15.18 345 139939 24514 79579590
Headache 410.50 15.18 330 139954 653442 78950662
Chills 404.99 15.18 880 139404 159354 79444750
Portal hypertension 403.55 15.18 213 140071 6895 79597209
Haematotoxicity 401.67 15.18 281 140003 15238 79588866
Joint swelling 390.91 15.18 31 140253 288615 79315489
Gastrointestinal toxicity 385.38 15.18 216 140068 7893 79596211
Product dose omission issue 373.97 15.18 14 140270 247523 79356581
Neoplasm progression 365.88 15.18 453 139831 51229 79552875
Enteritis 363.38 15.18 258 140026 14325 79589779
Rheumatoid arthritis 340.73 15.18 5 140279 208465 79395639
Dysaesthesia pharynx 326.73 15.18 76 140208 141 79603963
Gastrointestinal perforation 326.16 15.18 176 140108 5961 79598143
Pain 295.92 15.18 490 139794 703312 78900792
Therapy partial responder 295.40 15.18 245 140039 17152 79586952
Fall 294.78 15.18 255 140029 487374 79116730
Cardiotoxicity 294.53 15.18 212 140072 12027 79592077
Stridor 294.32 15.18 158 140126 5295 79598809
Malignant neoplasm progression 292.63 15.18 701 139583 135289 79468815
Type I hypersensitivity 290.70 15.18 146 140138 4252 79599852
Arthropathy 290.49 15.18 4 140280 177107 79426997
Metastases to lung 290.27 15.18 247 140037 17916 79586188
Non-cirrhotic portal hypertension 279.28 15.18 79 140205 408 79603696
Drug ineffective 279.01 15.18 974 139310 1079939 78524165
Febrile neutropenia 277.09 15.18 965 139319 230034 79374070
Throat tightness 274.39 15.18 290 139994 27617 79576487
Leukopenia 271.84 15.18 620 139664 115893 79488211
Neutrophil count decreased 267.46 15.18 542 139742 93417 79510687
Drug abuse 265.40 15.18 4 140280 162687 79441417
Peripheral swelling 263.40 15.18 74 140210 269543 79334561
Weight increased 253.26 15.18 86 140198 277300 79326804
Sinusitis 251.14 15.18 26 140258 195475 79408629
Flushing 243.92 15.18 503 139781 87765 79516339
Nasopharyngitis 243.72 15.18 72 140212 253809 79350295
Hyperammonaemia 235.10 15.18 178 140106 10915 79593189
Contraindicated product administered 234.17 15.18 10 140274 157528 79446576
Swelling 230.05 15.18 50 140234 216661 79387443
Decreased appetite 228.62 15.18 1197 139087 341221 79262883
Hyperammonaemic encephalopathy 226.20 15.18 127 140157 4655 79599449
Enterocolitis 225.07 15.18 194 140090 14318 79589786
Focal nodular hyperplasia 222.08 15.18 73 140211 669 79603435
Dysarthria 221.57 15.18 414 139870 67208 79536896
Anaphylactic shock 213.26 15.18 289 139995 35707 79568397
Cytokine release syndrome 213.25 15.18 289 139995 35709 79568395
Therapeutic product effect decreased 212.51 15.18 21 140263 163842 79440262
Splenomegaly 206.39 15.18 217 140067 20537 79583567
Depression 205.29 15.18 63 140221 216727 79387377
Ascites 199.88 15.18 423 139861 75139 79528965
Stomatitis 199.71 15.18 640 139644 146117 79457987
Hypomagnesaemia 199.12 15.18 322 139962 46589 79557515
Systemic lupus erythematosus 197.49 15.18 3 140281 121146 79482958
Product use issue 195.07 15.18 63 140221 209759 79394345
Abdominal discomfort 190.13 15.18 102 140182 250625 79353479
Insomnia 188.47 15.18 98 140186 245072 79359032
Drug interaction 186.52 15.18 276 140008 414907 79189197
Contusion 185.45 15.18 22 140262 148754 79455350
Abdominal pain 184.72 15.18 1245 139039 388324 79215780
Pain in extremity 184.42 15.18 222 140062 364316 79239788
Asthma 181.39 15.18 15 140269 135080 79469024
Dysphonia 172.51 15.18 337 139947 56535 79547569
Overdose 171.76 15.18 55 140229 184151 79419953
Anastomotic leak 170.97 15.18 66 140218 999 79603105
Maternal exposure during pregnancy 170.65 15.18 20 140264 136518 79467586
Metastases to peritoneum 169.38 15.18 102 140182 4270 79599834
Proteinuria 167.35 15.18 244 140040 32258 79571846
Influenza 167.02 15.18 17 140267 129589 79474515
Tumour perforation 165.59 15.18 51 140233 370 79603734
Nodular regenerative hyperplasia 165.32 15.18 69 140215 1292 79602812
Dyspnoea 164.98 15.18 2261 138023 854764 78749340
Asthenia 164.87 15.18 1495 138789 510194 79093910
Hyperhidrosis 162.05 15.18 610 139674 150882 79453222
Musculoskeletal stiffness 160.10 15.18 54 140230 174954 79429150
Arthritis 159.21 15.18 11 140273 114869 79489235
Colorectal cancer metastatic 157.94 15.18 65 140219 1173 79602931
Pyrexia 157.86 15.18 1855 138429 676854 78927250
Intestinal obstruction 156.94 15.18 276 140008 42744 79561360
Injection site pain 155.08 15.18 22 140262 129816 79474288
Pemphigus 152.50 15.18 5 140279 99577 79504527
Intentional product misuse 152.44 15.18 3 140281 95162 79508942
Hyperthermia 147.15 15.18 170 140114 17867 79586237
Varices oesophageal 146.95 15.18 105 140179 5886 79598218
Dysaesthesia 146.92 15.18 104 140180 5744 79598360
Laryngeal discomfort 143.96 15.18 50 140234 550 79603554
Psoriasis 142.80 15.18 3 140281 89584 79514520
Carcinoembryonic antigen increased 142.09 15.18 72 140212 2137 79601967
Oxygen saturation decreased 141.64 15.18 524 139760 128523 79475581
Bronchitis 140.94 15.18 29 140255 130615 79473489
Cardiac failure congestive 139.13 15.18 39 140245 142363 79461741
Osteoarthritis 138.87 15.18 3 140281 87306 79516798
Feeling hot 138.26 15.18 317 139967 59417 79544687
Anxiety 138.07 15.18 140 140144 248372 79355732
Glossodynia 137.28 15.18 12 140272 103325 79500779
Lower respiratory tract infection 134.69 15.18 31 140253 129189 79474915
Laryngeal oedema 132.86 15.18 112 140172 8017 79596087
Drug intolerance 131.21 15.18 163 140121 263956 79340148
Dehydration 130.81 15.18 815 139469 247372 79356732
Hypersensitivity 130.72 15.18 849 139435 261390 79342714
Blood cholesterol increased 128.93 15.18 4 140280 83716 79520388
Pneumonia 128.78 15.18 661 139623 659585 78944519
Large intestine perforation 128.53 15.18 143 140141 14424 79589680
Suicide attempt 127.58 15.18 4 140280 82928 79521176
Immune thrombocytopenia 127.45 15.18 157 140127 17648 79586456
Hospitalisation 125.02 15.18 11 140273 94225 79509879
Posterior reversible encephalopathy syndrome 124.84 15.18 190 140094 26091 79578013
Hepatic enzyme increased 122.11 15.18 86 140198 182524 79421580
Stress 121.89 15.18 4 140280 79608 79524496
Somnolence 121.33 15.18 145 140139 238836 79365268
Wound 120.83 15.18 28 140256 116151 79487953
Stomal varices 119.23 15.18 29 140255 71 79604033
Pneumatosis intestinalis 118.93 15.18 95 140189 6302 79597802
Myalgia 116.96 15.18 93 140191 185548 79418556
Condition aggravated 116.56 15.18 470 139814 500654 79103450
Exposure during pregnancy 114.29 15.18 20 140264 101112 79502992
Inappropriate schedule of product administration 114.16 15.18 46 140238 133582 79470522
Hypertensive crisis 112.88 15.18 160 140124 20610 79583494
Toxic leukoencephalopathy 112.24 15.18 50 140234 1104 79603000
Paraesthesia oral 111.71 15.18 158 140126 20313 79583791
Skin reaction 110.71 15.18 139 140145 15929 79588175
Tumour necrosis 110.24 15.18 58 140226 1864 79602240
Ileus 108.61 15.18 178 140106 26033 79578071
Rash pustular 108.44 15.18 116 140168 11195 79592909
Intravascular haemolysis 107.32 15.18 44 140240 786 79603318
Extravasation 106.70 15.18 72 140212 3678 79600426
Peritonitis 105.02 15.18 182 140102 27854 79576250
Memory impairment 104.77 15.18 33 140251 111701 79492403
General physical health deterioration 102.49 15.18 831 139453 274407 79329697
Disseminated intravascular coagulation 102.20 15.18 207 140077 35635 79568469
Intestinal perforation 101.82 15.18 139 140145 17287 79586817
Hypertransaminasaemia 101.69 15.18 115 140169 11809 79592295
Injection site erythema 101.41 15.18 10 140274 78187 79525917
Pericarditis 100.97 15.18 29 140255 104207 79499897
Mobility decreased 99.67 15.18 45 140239 122130 79481974
Acute coronary syndrome 99.27 15.18 152 140132 20981 79583123
Helicobacter infection 98.57 15.18 6 140278 69698 79534406
Confusional state 98.23 15.18 263 140021 317734 79286370
Cholinergic syndrome 95.90 15.18 44 140240 1043 79603061
Suicidal ideation 95.83 15.18 11 140273 76329 79527775
Migraine 95.23 15.18 19 140265 87474 79516630
Platelet count decreased 94.96 15.18 627 139657 194037 79410067
Hypokalaemia 94.13 15.18 501 139783 143539 79460565
Dihydropyrimidine dehydrogenase deficiency 93.62 15.18 26 140258 124 79603980
Administration site extravasation 92.94 15.18 46 140238 1297 79602807
Anaphylactic reaction 91.81 15.18 340 139944 83403 79520701
Drug hypersensitivity 91.73 15.18 248 140036 298668 79305436
Haemolytic anaemia 90.60 15.18 133 140151 17687 79586417
Tumour lysis syndrome 90.44 15.18 156 140128 23783 79580321
Portal shunt 90.41 15.18 22 140262 54 79604050
Tongue oedema 90.34 15.18 85 140199 7032 79597072
Treatment failure 89.13 15.18 101 140183 170385 79433719
Incorrect dose administered 86.92 15.18 15 140269 76615 79527489
Off label use 85.65 15.18 2143 138141 905072 78699032
Upper respiratory tract infection 85.34 15.18 27 140257 91141 79512963
Mucosal toxicity 85.12 15.18 34 140250 566 79603538
Anaemia 83.51 15.18 1170 139114 443845 79160259
Blood pressure fluctuation 83.47 15.18 10 140274 67135 79536969
Fluid retention 82.94 15.18 12 140272 69797 79534307
Band sensation 82.64 15.18 36 140248 752 79603352
Rhabdomyolysis 82.54 15.18 39 140245 103092 79501012
Chronic obstructive pulmonary disease 82.30 15.18 24 140260 85395 79518709
Duodenal ulcer perforation 81.97 15.18 10 140274 66201 79537903
Osteoporosis 81.85 15.18 3 140281 54109 79549995
Diffuse large B-cell lymphoma recurrent 81.48 15.18 64 140220 4143 79599961
Blister 80.20 15.18 56 140228 119420 79484684
Anastomotic fistula 80.02 15.18 23 140261 127 79603977
Tachycardia 79.21 15.18 560 139724 177208 79426896
Leukoencephalopathy 78.99 15.18 83 140201 7846 79596258
Metastases to lymph nodes 78.18 15.18 94 140190 10303 79593801
Rectal perforation 77.86 15.18 36 140248 869 79603235
Injection site reaction 76.61 15.18 5 140279 54780 79549324
Discomfort 76.53 15.18 65 140219 125552 79478552
Aggression 76.48 15.18 3 140281 50955 79553149
Sleep disorder 75.64 15.18 28 140256 85649 79518455
Anastomotic complication 75.00 15.18 29 140255 441 79603663
Pulmonary embolism 74.30 15.18 537 139747 171117 79432987
Electrocardiogram QT prolonged 74.17 15.18 33 140251 90353 79513751
Hallucination 74.07 15.18 29 140255 85716 79518388
Electrocardiogram ST segment elevation 73.34 15.18 82 140202 8315 79595789
Subileus 72.68 15.18 68 140216 5586 79598518
Cyanosis 72.46 15.18 146 140138 25036 79579068
Septic shock 72.11 15.18 415 139869 122386 79481718
Feeling abnormal 71.18 15.18 106 140178 159093 79445011
Ocular toxicity 69.48 15.18 33 140251 848 79603256
Hiccups 69.46 15.18 87 140197 9944 79594160
Sedation 68.98 15.18 6 140278 51889 79552215
Cholangitis 68.81 15.18 98 140186 12678 79591426
Myocardial infarction 68.29 15.18 138 140146 183991 79420113
Vascular pain 68.29 15.18 33 140251 882 79603222
Colon cancer metastatic 67.18 15.18 44 140240 2137 79601967
Blood glucose increased 67.02 15.18 62 140222 114913 79489191
Metastasis 66.73 15.18 71 140213 6809 79597295
Dizziness 66.49 15.18 599 139685 525842 79078262
Evans syndrome 66.09 15.18 26 140258 415 79603689
Nicotinic acid deficiency 66.07 15.18 21 140263 171 79603933
Stress cardiomyopathy 65.13 15.18 89 140195 11077 79593027
Gastric perforation 64.69 15.18 55 140229 3982 79600122
Palmar erythema 64.21 15.18 41 140243 1906 79602198
Coronary artery disease 63.80 15.18 18 140266 65456 79538648
Neuromyotonia 63.62 15.18 18 140266 93 79604011
Cellulitis 63.35 15.18 59 140225 109001 79495103
Herpes zoster 63.30 15.18 43 140241 93040 79511064
Illness 62.87 15.18 5 140279 46506 79557598
Dysphagia 62.34 15.18 398 139886 121738 79482366
Hyperbilirubinaemia 62.20 15.18 135 140149 24383 79579721
Injection site pruritus 61.77 15.18 3 140281 42280 79561824
Medication error 61.33 15.18 22 140262 68620 79535484
Nasal congestion 61.18 15.18 29 140255 76523 79527581
Hypoalbuminaemia 60.71 15.18 123 140161 21174 79582930
Wrong technique in product usage process 60.57 15.18 27 140257 73848 79530256
Choking sensation 60.12 15.18 52 140232 3854 79600250
Hepatic failure 60.09 15.18 240 140044 60972 79543132
Stoma site haemorrhage 59.87 15.18 39 140245 1877 79602227
Treatment noncompliance 59.79 15.18 10 140274 52258 79551846
Diffuse large B-cell lymphoma refractory 59.56 15.18 35 140249 1400 79602704
Drug dependence 59.21 15.18 3 140281 40766 79563338
Influenza like illness 59.12 15.18 26 140258 71681 79532423
Gait disturbance 58.60 15.18 179 140105 207327 79396777
Infusion related hypersensitivity reaction 58.07 15.18 23 140261 374 79603730
Urinary tract infection 57.86 15.18 267 140017 274245 79329859
Drug level increased 57.33 15.18 3 140281 39648 79564456
Type 2 diabetes mellitus 56.98 15.18 15 140269 57107 79546997
Chemical peritonitis 56.82 15.18 21 140263 280 79603824
Laryngeal dyspnoea 56.82 15.18 21 140263 280 79603824
Oesophageal varices haemorrhage 56.48 15.18 52 140232 4184 79599920
International normalised ratio increased 56.47 15.18 40 140244 84681 79519423
Colitis 56.34 15.18 267 140017 73040 79531064
ECG signs of myocardial ischaemia 56.34 15.18 22 140262 344 79603760
Vocal cord paralysis 55.89 15.18 42 140242 2545 79601559
Hepatic atrophy 55.73 15.18 23 140261 418 79603686
Encapsulating peritoneal sclerosis 55.50 15.18 28 140256 823 79603281
Large intestinal obstruction 55.04 15.18 46 140238 3253 79600851
Speech disorder 54.68 15.18 215 140069 54230 79549874
Productive cough 54.67 15.18 45 140239 88286 79515818
Psychotic disorder 54.46 15.18 5 140279 41397 79562707
Hyperpyrexia 54.08 15.18 60 140224 6032 79598072
Gastrointestinal anastomotic leak 54.04 15.18 24 140260 526 79603578
Hypervolaemia 53.95 15.18 6 140278 42684 79561420
Drug reaction with eosinophilia and systemic symptoms 53.43 15.18 23 140261 64221 79539883
Skin fissures 53.10 15.18 88 140196 12985 79591119
Loss of personal independence in daily activities 52.27 15.18 62 140222 102518 79501586
Intentional product use issue 52.24 15.18 119 140165 151993 79452111
Enterovesical fistula 52.16 15.18 30 140254 1152 79602952
Viral infection 52.03 15.18 7 140277 43009 79561095
Trichomegaly 51.96 15.18 16 140268 116 79603988
Hepatocellular injury 51.95 15.18 193 140091 47400 79556704
Cough 51.36 15.18 406 139878 366383 79237721
Prinzmetal angina 51.28 15.18 34 140250 1686 79602418
Heart rate decreased 51.23 15.18 30 140254 70286 79533818
Necrotising fasciitis 50.99 15.18 58 140226 5992 79598112
Anaphylactoid reaction 50.91 15.18 55 140229 5367 79598737
Road traffic accident 50.73 15.18 8 140276 43656 79560448
Recall phenomenon 50.55 15.18 29 140255 1108 79602996
Trismus 50.53 15.18 55 140229 5412 79598692
Cataract 50.46 15.18 23 140261 62097 79542007
Infusion related reaction 50.46 15.18 623 139661 229614 79374490
Splenorenal shunt 50.23 15.18 11 140273 13 79604091
Pulmonary toxicity 49.89 15.18 85 140199 12829 79591275
Blood pressure systolic increased 49.63 15.18 28 140256 66958 79537146
Metastases to meninges 49.57 15.18 45 140239 3556 79600548
Emotional distress 49.56 15.18 6 140278 39963 79564141
Dysgeusia 48.95 15.18 215 140069 56962 79547142
Small intestinal perforation 48.95 15.18 43 140241 3254 79600850
White blood cell count decreased 48.63 15.18 526 139758 187762 79416342
Wound dehiscence 48.57 15.18 59 140225 6536 79597568
Ileal perforation 47.88 15.18 27 140257 998 79603106
Head injury 47.87 15.18 5 140279 37364 79566740
Tachypnoea 47.40 15.18 144 140140 31919 79572185
Metastases to spleen 47.38 15.18 23 140261 621 79603483
Enterocutaneous fistula 47.25 15.18 34 140250 1927 79602177
Portal venous gas 47.08 15.18 20 140264 392 79603712
Rhinorrhoea 46.77 15.18 39 140245 76035 79528069
Acute abdomen 46.75 15.18 41 140243 3096 79601008
Malignant ascites 46.67 15.18 28 140256 1164 79602940
Hyperkalaemia 46.58 15.18 81 140203 114317 79489787
Metastases to ovary 46.41 15.18 19 140265 338 79603766
Transdifferentiation of neoplasm 46.39 15.18 14 140270 94 79604010
Liver function test abnormal 46.28 15.18 28 140256 64447 79539657
Portal vein thrombosis 45.99 15.18 54 140230 5773 79598331
Formication 45.50 15.18 50 140234 4973 79599131
Neutropenic sepsis 45.24 15.18 127 140157 26937 79577167
Biliary tract infection 45.21 15.18 29 140255 1359 79602745
Hypercreatinaemia 45.04 15.18 18 140266 300 79603804
Sensation of foreign body 44.96 15.18 52 140232 5470 79598634
Metastases to bone marrow 44.87 15.18 24 140260 798 79603306
Diabetes mellitus 44.82 15.18 43 140241 78347 79525757
Thrombocytopenic purpura 44.48 15.18 36 140248 2433 79601671
Temperature intolerance 44.45 15.18 69 140215 9636 79594468
Obesity 44.23 15.18 5 140279 35120 79568984
Cold sweat 44.10 15.18 100 140184 18599 79585505
Blood lactate dehydrogenase increased 43.72 15.18 160 140124 39010 79565094
Drug withdrawal syndrome 43.57 15.18 5 140279 34713 79569391
Fatigue 43.50 15.18 1275 139009 928452 78675652
Balance disorder 43.04 15.18 67 140217 98790 79505314
Haemoglobinuria 42.91 15.18 23 140261 768 79603336
Hypertension 42.87 15.18 819 139465 330173 79273931
Oxygen saturation normal 42.76 15.18 8 140276 0 79604104
Performance status decreased 42.30 15.18 53 140231 6060 79598044
Hypertrichosis 42.29 15.18 27 140257 1255 79602849
Hypotension 42.16 15.18 1043 139241 439274 79164830
Adverse event 42.04 15.18 27 140257 60187 79543917
Gene mutation 41.83 15.18 36 140248 2650 79601454
Periportal sinus dilatation 41.77 15.18 14 140270 137 79603967
Oropharyngeal discomfort 41.62 15.18 57 140227 7109 79596995
Type II hypersensitivity 41.57 15.18 11 140273 42 79604062
Acute respiratory distress syndrome 41.04 15.18 170 140114 43897 79560207
Basal cell carcinoma 40.91 15.18 8 140276 37367 79566737
Adverse drug reaction 40.86 15.18 34 140250 66358 79537746
Steatohepatitis 40.70 15.18 24 140260 966 79603138
Hallucination, visual 40.37 15.18 5 140279 32724 79571380
Embolism 40.15 15.18 81 140203 13901 79590203
Unevaluable event 40.09 15.18 24 140260 55561 79548543
Amaurosis fugax 40.06 15.18 23 140261 880 79603224
Oedema peripheral 39.74 15.18 270 140014 252018 79352086
Perforation 39.67 15.18 27 140257 1399 79602705
Hepatic function abnormal 39.64 15.18 242 140042 72865 79531239
Pharyngeal paraesthesia 39.42 15.18 35 140249 2686 79601418
Gastric varices haemorrhage 39.26 15.18 18 140266 426 79603678
Gait inability 39.02 15.18 28 140256 58889 79545215
Alopecia 38.77 15.18 243 140041 231112 79372992
Neutropenic colitis 38.72 15.18 49 140235 5658 79598446
Peripheral motor neuropathy 38.56 15.18 38 140246 3329 79600775
Haematemesis 38.45 15.18 188 140096 52076 79552028
Chest discomfort 38.15 15.18 391 139893 137653 79466451
Liver abscess 37.98 15.18 50 140234 6004 79598100
Aortic thrombosis 37.70 15.18 28 140256 1667 79602437
Prescribed underdose 37.68 15.18 4 140280 29510 79574594
Abortion spontaneous 37.66 15.18 4 140280 29503 79574601
Abnormal behaviour 37.42 15.18 9 140275 36412 79567692
Cold dysaesthesia 37.23 15.18 8 140276 8 79604096
Oropharyngeal pain 37.17 15.18 86 140198 109267 79494837
Irritability 37.07 15.18 13 140271 41131 79562973
Intestinal ischaemia 37.06 15.18 76 140208 13194 79590910
Haematoma 37.00 15.18 23 140261 52172 79551932
Neck pain 36.92 15.18 47 140237 75370 79528734
Oesophagitis 36.76 15.18 110 140174 24179 79579925
Peripheral nerve injury 36.61 15.18 20 140264 694 79603410
Cardiac disorder 36.52 15.18 37 140247 65720 79538384
Eosinophilia 36.50 15.18 17 140267 45328 79558776
Underdose 36.49 15.18 7 140277 33144 79570960
Peripheral sensorimotor neuropathy 36.40 15.18 35 140249 2975 79601129
Factor VII deficiency 36.18 15.18 9 140275 25 79604079
Hypophagia 36.14 15.18 167 140117 45200 79558904
Full blood count abnormal 36.11 15.18 13 140271 40461 79563643
Ear pain 36.05 15.18 7 140277 32862 79571242
Aortitis 36.01 15.18 26 140258 1481 79602623
Withdrawal syndrome 35.98 15.18 3 140281 26851 79577253
Congestive cardiomyopathy 35.94 15.18 70 140214 11710 79592394
Impaired healing 35.74 15.18 62 140222 87593 79516511
Nephrolithiasis 35.72 15.18 25 140259 53266 79550838
K-ras gene mutation 35.45 15.18 10 140274 51 79604053
Small intestinal obstruction 35.30 15.18 117 140167 27155 79576949
COVID-19 35.22 15.18 150 140134 157524 79446580
Hypovolaemic shock 35.11 15.18 71 140213 12205 79591899
Portal vein dilatation 34.98 15.18 10 140274 54 79604050
Colitis ulcerative 34.89 15.18 9 140275 34733 79569371
Nervousness 34.84 15.18 8 140276 33407 79570697
Accidental overdose 34.82 15.18 13 140271 39568 79564536
Oesophageal haemorrhage 34.48 15.18 27 140257 1740 79602364
Jaundice 34.43 15.18 185 140099 53164 79550940
Splenic artery thrombosis 34.38 15.18 10 140274 58 79604046
Hepatectomy 34.21 15.18 13 140271 188 79603916
Granulocyte count decreased 33.93 15.18 27 140257 1781 79602323
Femur fracture 33.50 15.18 13 140271 38639 79565465
Disease recurrence 32.69 15.18 159 140125 43950 79560154
Hepatic lesion 32.60 15.18 50 140234 6909 79597195
Cytopenia 32.46 15.18 94 140190 20289 79583815
Blood pressure immeasurable 32.36 15.18 28 140256 2076 79602028
Thrombotic microangiopathy 32.11 15.18 93 140191 20076 79584028
Hypoglycaemia 32.09 15.18 83 140201 101511 79502593
Noninfective epididymitis 32.07 15.18 6 140278 0 79604104
Lip oedema 31.90 15.18 47 140237 6269 79597835
Cholestasis 31.82 15.18 178 140106 51931 79552173
Heart rate irregular 31.81 15.18 9 140275 32670 79571434
Therapy interrupted 31.70 15.18 8 140276 31333 79572771
Night sweats 31.66 15.18 27 140257 52068 79552036
Respiratory distress 31.55 15.18 193 140091 58146 79545958
Device issue 31.42 15.18 5 140279 27103 79577001
Gastrooesophageal reflux disease 30.80 15.18 88 140196 104158 79499946
Sciatica 30.80 15.18 10 140274 33212 79570892
Toxicity to various agents 30.74 15.18 539 139745 421001 79183103
Guillain-Barre syndrome 30.74 15.18 56 140228 8909 79595195
Oral dysaesthesia 30.65 15.18 12 140272 189 79603915
Musculoskeletal pain 30.54 15.18 86 140198 102268 79501836
Osteomyelitis 30.28 15.18 10 140274 32855 79571249
Hydronephrosis 30.25 15.18 83 140201 17371 79586733
Gastrointestinal obstruction 30.17 15.18 25 140259 1747 79602357
Biliary fistula 30.10 15.18 10 140274 95 79604009
Skin laceration 30.06 15.18 7 140277 28955 79575149
Tooth disorder 30.04 15.18 5 140279 26228 79577876
Blood pressure diastolic decreased 30.01 15.18 8 140276 30208 79573896
Muscle contractions involuntary 29.89 15.18 35 140249 3730 79600374
Haemolytic uraemic syndrome 29.87 15.18 38 140246 4411 79599693
Haemolysis 29.64 15.18 68 140216 12744 79591360
Right ventricular ejection fraction decreased 29.62 15.18 9 140275 62 79604042
Autoimmune haemolytic anaemia 29.57 15.18 53 140231 8327 79595777
Perforation bile duct 29.55 15.18 8 140276 34 79604070
Bursitis 29.54 15.18 13 140271 35831 79568273
Appendicitis noninfective 29.42 15.18 7 140277 15 79604089
Short-bowel syndrome 29.35 15.18 16 140268 553 79603551
Dysentery 29.33 15.18 21 140263 1181 79602923
Retching 29.23 15.18 82 140202 17385 79586719
Poor quality sleep 29.21 15.18 3 140281 22719 79581385
Rectal cancer metastatic 29.12 15.18 15 140269 461 79603643
Limb injury 28.99 15.18 8 140276 29520 79574584
Pulmonary sarcoidosis 28.96 15.18 22 140262 1355 79602749
Pelvic fluid collection 28.90 15.18 18 140266 801 79603303
Localised infection 28.86 15.18 15 140269 37560 79566544
Loss of consciousness 28.80 15.18 435 139849 167508 79436596
Failure to anastomose 28.78 15.18 12 140272 224 79603880
Pulmonary artery thrombosis 28.75 15.18 22 140262 1370 79602734
Suffocation feeling 28.73 15.18 24 140260 1696 79602408
Cytomegalovirus infection 28.59 15.18 20 140264 42624 79561480
Blood creatine phosphokinase increased 28.57 15.18 45 140239 66045 79538059
Tendonitis 28.53 15.18 4 140280 23826 79580278
Oedema 28.44 15.18 111 140173 119469 79484635
Sciatic nerve palsy 27.92 15.18 9 140275 77 79604027
Blood glucose decreased 27.92 15.18 6 140278 26228 79577876
Post embolisation syndrome 27.62 15.18 9 140275 80 79604024
Infection 27.47 15.18 282 140002 241430 79362674
Medical device site extravasation 27.44 15.18 6 140278 7 79604097
Cystitis radiation 27.27 15.18 11 140273 188 79603916
Amnesia 27.19 15.18 43 140241 63014 79541090
Koebner phenomenon 27.14 15.18 8 140276 49 79604055
Inflammation 27.08 15.18 80 140204 93673 79510431
Heat stroke 26.88 15.18 23 140261 1680 79602424
Type III immune complex mediated reaction 26.74 15.18 16 140268 662 79603442
Mucosal disorder 26.69 15.18 32 140252 3496 79600608
Carbohydrate antigen 19-9 increased 26.58 15.18 14 140270 451 79603653
Dry eye 26.56 15.18 16 140268 36915 79567189
Hyperaemia 26.53 15.18 30 140254 3080 79601024
Sinus bradycardia 26.41 15.18 6 140278 25241 79578863
Perineal disorder 26.40 15.18 7 140277 27 79604077
Hypoacusis 26.36 15.18 10 140274 30140 79573964
Labelled drug-drug interaction medication error 26.21 15.18 8 140276 27642 79576462
Hypersplenism 26.15 15.18 15 140269 573 79603531
Gastrointestinal necrosis 26.10 15.18 40 140244 5525 79598579
Multiple sclerosis 26.07 15.18 4 140280 22278 79581826
Respiratory arrest 26.02 15.18 38 140246 57512 79546592
Pelvic abscess 26.01 15.18 25 140259 2124 79601980
Hyperfibrinolysis 26.00 15.18 7 140277 29 79604075
Venoocclusive disease 25.99 15.18 36 140248 4537 79599567
Pharyngeal dyskinesia 25.98 15.18 8 140276 58 79604046
Intervertebral disc protrusion 25.97 15.18 5 140279 23616 79580488
Hallucination, auditory 25.92 15.18 3 140281 20690 79583414
Vasospasm 25.82 15.18 19 140265 1115 79602989
Adenocarcinoma 25.79 15.18 33 140251 3853 79600251
Injection site paraesthesia 25.66 15.18 15 140269 594 79603510
Heart rate increased 25.65 15.18 117 140167 120607 79483497
Pulmonary hypertension 25.64 15.18 28 140256 48052 79556052
Pain in jaw 25.59 15.18 26 140258 46125 79557979
Hepatic encephalopathy 25.54 15.18 97 140187 24069 79580035
Endothelial dysfunction 25.33 15.18 11 140273 228 79603876
Hypoaesthesia oral 25.32 15.18 68 140216 14056 79590048
Product substitution issue 25.21 15.18 3 140281 20253 79583851
Hypercholesterolaemia 25.16 15.18 5 140279 23090 79581014
Hypersomnia 25.14 15.18 5 140279 23081 79581023
Swelling face 25.02 15.18 55 140229 71157 79532947
Eczema 25.00 15.18 21 140263 40797 79563307
Full blood count decreased 24.99 15.18 8 140276 26811 79577293
Liver function test increased 24.93 15.18 20 140264 39753 79564351
Toxic epidermal necrolysis 24.85 15.18 25 140259 44556 79559548
Subacute cutaneous lupus erythematosus 24.84 15.18 31 140253 3530 79600574
Thrombotic thrombocytopenic purpura 24.67 15.18 42 140242 6334 79597770
Gastric disorder 24.51 15.18 18 140266 37415 79566689
Nephrotic syndrome 24.42 15.18 58 140226 11116 79592988
Tumour ulceration 24.40 15.18 11 140273 250 79603854
Abdominal wall oedema 24.38 15.18 5 140279 3 79604101
Pseudocirrhosis 24.13 15.18 15 140269 665 79603439
Tumour haemorrhage 24.12 15.18 33 140251 4111 79599993
Platelet count increased 24.10 15.18 5 140279 22401 79581703
Papilloedema 24.04 15.18 41 140243 6192 79597912
Colon cancer recurrent 23.95 15.18 9 140275 126 79603978
Metastases to muscle 23.93 15.18 12 140272 348 79603756
Bronchostenosis 23.91 15.18 15 140269 676 79603428
Surgery 23.84 15.18 14 140270 32752 79571352
Fistula of small intestine 23.82 15.18 16 140268 811 79603293
Gout 23.75 15.18 7 140277 24742 79579362
Gallbladder disorder 23.74 15.18 3 140281 19337 79584767
Neoplasm recurrence 23.69 15.18 33 140251 4181 79599923
Cachexia 23.65 15.18 57 140227 11026 79593078
Device related infection 23.56 15.18 121 140163 34173 79569931
Blood potassium increased 23.53 15.18 11 140273 29264 79574840
Neutropenic infection 23.46 15.18 25 140259 2402 79601702
Dry mouth 23.38 15.18 78 140206 87941 79516163
Fulminant type 1 diabetes mellitus 23.35 15.18 20 140264 1463 79602641
Immune effector cell-associated neurotoxicity syndrome 23.26 15.18 39 140245 5809 79598295
Acute promyelocytic leukaemia 23.25 15.18 20 140264 1471 79602633
Acute polyneuropathy 23.14 15.18 13 140271 477 79603627
Immunodeficiency 23.12 15.18 5 140279 21763 79582341
Tonic clonic movements 23.09 15.18 24 140260 2240 79601864
Wheezing 23.08 15.18 116 140168 116548 79487556
Pigmentation disorder 23.06 15.18 38 140246 5580 79598524
Death 22.99 15.18 791 139493 565723 79038381
Gastric varices 22.95 15.18 15 140269 726 79603378
Acral peeling skin syndrome 22.94 15.18 7 140277 49 79604055
Skin discolouration 22.89 15.18 23 140261 41011 79563093
Skin disorder 22.79 15.18 119 140165 33824 79570280
Pneumatosis 22.77 15.18 16 140268 873 79603231
Pneumonitis 22.72 15.18 184 140100 60676 79543428
Protein urine 22.67 15.18 20 140264 1522 79602582
Rectal cancer recurrent 22.66 15.18 6 140278 23 79604081
Necrotic lymphadenopathy 22.64 15.18 8 140276 93 79604011
Musculoskeletal disorder 22.63 15.18 5 140279 21443 79582661
Gastrointestinal mucosal necrosis 22.48 15.18 10 140274 220 79603884
Delirium 22.47 15.18 75 140209 84552 79519552
Toothache 22.44 15.18 4 140280 19966 79584138
Retroperitoneal abscess 22.43 15.18 12 140272 399 79603705
Haemorrhage intracranial 22.39 15.18 9 140275 26184 79577920
Hypothyroidism 22.34 15.18 36 140248 52356 79551748
Renal hydrocele 22.26 15.18 6 140278 25 79604079
Musculoskeletal discomfort 22.23 15.18 4 140280 19831 79584273
Eye pain 22.20 15.18 20 140264 37558 79566546
Obstruction gastric 22.20 15.18 21 140263 1749 79602355
Back pain 22.14 15.18 389 139895 303791 79300313
Hyperlipasaemia 21.99 15.18 18 140266 1236 79602868
Gastrointestinal stoma complication 21.75 15.18 25 140259 2612 79601492
Astringent therapy 21.71 15.18 6 140278 28 79604076
Eczema impetiginous 21.71 15.18 6 140278 28 79604076
Fingerprint loss 21.71 15.18 7 140277 60 79604044
Oropharyngeal spasm 21.67 15.18 12 140272 428 79603676
Perihepatic abscess 21.54 15.18 9 140275 169 79603935
Tumour fistulisation 21.54 15.18 6 140278 29 79604075
Oesophagobronchial fistula 21.45 15.18 10 140274 246 79603858
Livedo reticularis 21.40 15.18 31 140253 4072 79600032
Diaphragmatic operation 21.37 15.18 6 140278 30 79604074
Abdominal abscess 21.32 15.18 42 140242 7085 79597019
Procedural pain 21.31 15.18 7 140277 23077 79581027
Product administration error 21.26 15.18 15 140269 31831 79572273
Ischiorectal hernia 21.25 15.18 5 140279 10 79604094
Hand-foot-genital syndrome 21.25 15.18 5 140279 10 79604094
Hepatic vein stenosis 21.21 15.18 7 140277 65 79604039
Interventricular septum rupture 21.21 15.18 6 140278 31 79604073
Catheter site extravasation 21.19 15.18 12 140272 447 79603657
Sepsis 21.11 15.18 622 139662 268806 79335298
Cardiomegaly 21.02 15.18 10 140274 26342 79577762
Colorectal cancer recurrent 21.02 15.18 7 140277 67 79604037
Organising pneumonia 20.97 15.18 54 140230 10885 79593219
Adenocarcinoma metastatic 20.93 15.18 9 140275 182 79603922
Feeling cold 20.88 15.18 103 140181 28626 79575478
Pneumonitis chemical 20.88 15.18 12 140272 460 79603644
Cardiac ventricular disorder 20.86 15.18 11 140273 355 79603749
Microangiopathic haemolytic anaemia 20.86 15.18 19 140265 1508 79602596
Product prescribing error 20.84 15.18 29 140255 44784 79559320
Adenocarcinoma of colon 20.78 15.18 36 140248 5505 79598599
Transient aphasia 20.69 15.18 12 140272 468 79603636
Limbic encephalitis 20.69 15.18 15 140269 860 79603244
Stomal hernia 20.67 15.18 11 140273 362 79603742
Atypical haemolytic uraemic syndrome 20.64 15.18 16 140268 1016 79603088
Mucosal necrosis 20.61 15.18 8 140276 123 79603981
Blood alkaline phosphatase abnormal 20.58 15.18 15 140269 867 79603237
Restless legs syndrome 20.57 15.18 5 140279 20087 79584017
Pulmonary congestion 20.55 15.18 11 140273 27089 79577015
Acute myeloid leukaemia 20.54 15.18 108 140176 30777 79573327
Rectosigmoid cancer 20.50 15.18 10 140274 273 79603831
Neutrophil count abnormal 20.41 15.18 28 140256 3498 79600606
Therapeutic response unexpected 20.35 15.18 5 140279 19941 79584163
C-reactive protein increased 20.34 15.18 138 140146 128889 79475215
Disability 20.20 15.18 3 140281 17117 79586987
Premature delivery 20.16 15.18 8 140276 23459 79580645
Hernia 20.10 15.18 3 140281 17056 79587048
Hepatic infarction 20.09 15.18 15 140269 900 79603204
Pneumoperitoneum 20.01 15.18 26 140258 3082 79601022
Epistaxis 19.95 15.18 291 139993 111224 79492880
Osteopenia 19.95 15.18 4 140280 18360 79585744
Hiatus hernia 19.94 15.18 8 140276 23304 79580800
Therapy non-responder 19.88 15.18 89 140195 92216 79511888
Hypocapnia 19.87 15.18 13 140271 630 79603474
Drug eruption 19.87 15.18 29 140255 43906 79560198
Prostatic calcification 19.68 15.18 7 140277 83 79604021
Palpitations 19.67 15.18 136 140148 126474 79477630
Allodynia 19.62 15.18 19 140265 1629 79602475
Diaphragmatic paralysis 19.58 15.18 16 140268 1096 79603008
Chronic myeloid leukaemia 19.57 15.18 28 140256 3636 79600468
Necrotising oesophagitis 19.57 15.18 16 140268 1097 79603007
Grip strength decreased 19.55 15.18 7 140277 21862 79582242
Venous thrombosis limb 19.46 15.18 31 140253 4426 79599678
Sputum discoloured 19.37 15.18 7 140277 21736 79582368
Mental disorder 19.30 15.18 16 140268 31286 79572818
Metastases to diaphragm 19.19 15.18 6 140278 46 79604058
Mucocutaneous rash 19.08 15.18 6 140278 47 79604057
Urticaria 19.07 15.18 221 140063 184980 79419124
Extrapyramidal disorder 19.05 15.18 8 140276 22671 79581433
Laboratory test abnormal 19.01 15.18 13 140271 28035 79576069
Mental impairment 18.98 15.18 5 140279 19031 79585073
Catabolic state 18.96 15.18 7 140277 93 79604011
Gastric stenosis 18.92 15.18 8 140276 155 79603949
Chemotherapy cardiotoxicity attenuation 18.91 15.18 5 140279 19 79604085
Mixed adenoneuroendocrine carcinoma 18.91 15.18 5 140279 19 79604085
Monocytopenia 18.87 15.18 8 140276 156 79603948
Anal sphincter atony 18.82 15.18 10 140274 328 79603776
Seizure 18.80 15.18 227 140057 188607 79415497
Macroglossia 18.74 15.18 16 140268 1165 79602939
Tremor 18.73 15.18 411 139873 169672 79434432
Axonal and demyelinating polyneuropathy 18.71 15.18 5 140279 20 79604084
Dementia 18.71 15.18 10 140274 24649 79579455
Induration 18.68 15.18 20 140264 1932 79602172
Inferior vena cava stenosis 18.65 15.18 6 140278 51 79604053
Neonatal asphyxia 18.61 15.18 4 140280 4 79604100
Intrahepatic portal hepatic venous fistula 18.61 15.18 4 140280 4 79604100
Live birth 18.55 15.18 5 140279 18739 79585365
Retroperitoneal mass 18.47 15.18 9 140275 245 79603859
Peripheral ischaemia 18.45 15.18 47 140237 9410 79594694
No adverse event 18.39 15.18 23 140261 37169 79566935
Blood triglycerides increased 18.36 15.18 7 140277 21033 79583071
Oesophageal fistula 18.32 15.18 11 140273 458 79603646
Cystitis 18.30 15.18 41 140243 52691 79551413
Obstructive airways disorder 18.28 15.18 17 140267 31442 79572662
Testicular disorder 18.14 15.18 9 140275 255 79603849
Intervertebral disc degeneration 18.10 15.18 3 140281 15782 79588322
Chronic kidney disease 18.00 15.18 58 140226 66096 79538008
Pulmonary oedema 17.88 15.18 87 140197 88167 79515937
Renal disorder 17.88 15.18 29 140255 42076 79562028
Ankle fracture 17.81 15.18 4 140280 16965 79587139
Endometrial dysplasia 17.81 15.18 5 140279 25 79604079
Angioedema 17.80 15.18 71 140213 75964 79528140
Radiation interaction 17.79 15.18 6 140278 60 79604044
Gastritis 17.75 15.18 36 140248 47957 79556147
Metastases to central nervous system 17.53 15.18 66 140218 16309 79587795
Pachymeningitis 17.46 15.18 9 140275 277 79603827
Growth of eyelashes 17.42 15.18 8 140276 190 79603914
VIth nerve disorder 17.34 15.18 5 140279 28 79604076
Aplastic anaemia 17.30 15.18 5 140279 17900 79586204
Metastases to retroperitoneum 17.15 15.18 10 140274 394 79603710
Pancreatic neuroendocrine tumour metastatic 17.13 15.18 7 140277 124 79603980
Dry skin 17.09 15.18 189 140095 67806 79536298
Lymphangiosis carcinomatosa 17.06 15.18 20 140264 2134 79601970
Jaw operation 16.90 15.18 13 140271 816 79603288
Pulmonary fibrosis 16.81 15.18 134 140150 43978 79560126
Pruritus 16.79 15.18 852 139432 393796 79210308
Xeroderma 16.72 15.18 9 140275 303 79603801
Movement disorder 16.72 15.18 14 140270 27245 79576859
Mood swings 16.72 15.18 7 140277 19873 79584231
Lacrimation disorder 16.68 15.18 4 140280 9 79604095
Blindness transient 16.59 15.18 30 140254 4746 79599358
Toxic encephalopathy 16.55 15.18 51 140233 11389 79592715
Infusion site hypoaesthesia 16.39 15.18 5 140279 35 79604069
Kidney infection 16.38 15.18 9 140275 21842 79582262
Ventricular dysfunction 16.24 15.18 34 140250 5989 79598115
Vascular access site occlusion 16.23 15.18 6 140278 80 79604024
Gastroenteritis viral 16.18 15.18 12 140272 24819 79579285
Nephritis allergic 16.10 15.18 12 140272 718 79603386
Abdominal sepsis 16.09 15.18 19 140265 2043 79602061
Drug ineffective for unapproved indication 16.07 15.18 42 140242 51196 79552908
Neuronal neuropathy 16.03 15.18 3 140281 0 79604104
Myoclonus 16.01 15.18 15 140269 27645 79576459
Catheter site bruise 15.99 15.18 10 140274 448 79603656
Lethargy 15.98 15.18 81 140203 81211 79522893
Hemiparaesthesia 15.96 15.18 8 140276 232 79603872
Splenic abscess 15.91 15.18 11 140273 585 79603519
Glycosylated haemoglobin increased 15.85 15.18 7 140277 19253 79584851
Device malfunction 15.83 15.18 9 140275 21439 79582665
Haemoglobin abnormal 15.83 15.18 37 140247 7017 79597087
Therapy cessation 15.83 15.18 26 140258 37536 79566568
Depressed mood 15.78 15.18 39 140245 48441 79555663
Squamous cell carcinoma 15.78 15.18 4 140280 15618 79588486
Soft tissue necrosis 15.77 15.18 13 140271 902 79603202
Lymphadenopathy mediastinal 15.76 15.18 28 140256 4368 79599736
Cerebral vasoconstriction 15.75 15.18 16 140268 1454 79602650
Aortic intramural haematoma 15.74 15.18 7 140277 154 79603950
Mechanical ileus 15.72 15.18 13 140271 906 79603198
Coombs test positive 15.71 15.18 8 140276 240 79603864
Joint effusion 15.71 15.18 6 140278 18008 79586096
Ichthyosis 15.65 15.18 7 140277 156 79603948
Motion sickness 15.64 15.18 13 140271 912 79603192
Diffuse alveolar damage 15.64 15.18 25 140259 3579 79600525
Upper limb fracture 15.64 15.18 6 140278 17961 79586143
Pollakiuria 15.57 15.18 26 140258 37291 79566813
Systemic infection 15.55 15.18 45 140239 9707 79594397
Agitation 15.54 15.18 107 140177 99608 79504496
Aortic dissection 15.50 15.18 27 140257 4148 79599956
Lip dry 15.47 15.18 4 140280 15414 79588690
Vaginal cellulitis 15.41 15.18 6 140278 93 79604011
Aplasia 15.40 15.18 39 140245 7781 79596323
Red blood cell count decreased 15.25 15.18 51 140233 57462 79546642
Hip fracture 15.23 15.18 19 140265 30742 79573362
Deep vein thrombosis 15.21 15.18 298 139986 120621 79483483

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01XA03 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
OTHER ANTINEOPLASTIC AGENTS
Platinum compounds
FDA EXT N0000175073 Platinum-containing Compounds
FDA EPC N0000175413 Platinum-based Drug
MeSH PA D000970 Antineoplastic Agents
CHEBI has role CHEBI:25435 mutagens
CHEBI has role CHEBI:35610 antineoplastic agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Metastasis from malignant tumor of colon indication 314998002
Malignant tumor of stomach indication 363349007 DOID:10534
Small intestine cancer indication 363509000 DOID:10154
Lymph Node Positive Colorectal Carcinoma indication
Malignant tumor of colon off-label use 363406005 DOID:219
Malignant tumor of testis off-label use 363449006 DOID:2998
Adenocarcinoma of pancreas off-label use 700423003 DOID:4074
Fibrosis of lung contraindication 51615001 DOID:3770
Interstitial pneumonia contraindication 64667001
Kidney disease contraindication 90708001 DOID:557
Liver function tests abnormal contraindication 166603001
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Peripheral nerve disease contraindication 302226006
Breastfeeding (mother) contraindication 413712001




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4021355 VUID
N0000148774 NUI
D01790 KEGG_DRUG
4021355 VANDF
C0069717 UMLSCUI
CHEBI:31941 CHEBI
1PT PDB_CHEM_ID
CHEMBL414804 ChEMBL_ID
D000077150 MESH_DESCRIPTOR_UI
DB00526 DRUGBANK_ID
7433 IUPHAR_LIGAND_ID
6012 INN_ID
04ZR38536J UNII
9887053 PUBCHEM_CID
32592 RXNORM
165344 MMSL
16916 MMSL
d04811 MMSL
007166 NDDF
327032007 SNOMEDCT_US
395814003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-3985 INJECTION, SOLUTION, CONCENTRATE 50 mg INTRAVENOUS NDA 28 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-3985 INJECTION, SOLUTION, CONCENTRATE 50 mg INTRAVENOUS NDA 28 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-3986 INJECTION, SOLUTION, CONCENTRATE 100 mg INTRAVENOUS NDA 28 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-3986 INJECTION, SOLUTION, CONCENTRATE 100 mg INTRAVENOUS NDA 28 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 0781-3315 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 29 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 0781-3315 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 29 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 0781-3317 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 29 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 0781-3317 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 29 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 0781-9315 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 28 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 0781-9317 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 28 sections
OXALIPLATIN HUMAN PRESCRIPTION DRUG LABEL 1 0955-1725 INJECTION, SOLUTION, CONCENTRATE 5 mg INTRAVENOUS NDA AUTHORIZED GENERIC 33 sections
OXALIPLATIN HUMAN PRESCRIPTION DRUG LABEL 1 0955-1725 INJECTION, SOLUTION, CONCENTRATE 5 mg INTRAVENOUS NDA AUTHORIZED GENERIC 33 sections
OXALIPLATIN HUMAN PRESCRIPTION DRUG LABEL 1 0955-1727 INJECTION, SOLUTION, CONCENTRATE 5 mg INTRAVENOUS NDA AUTHORIZED GENERIC 33 sections
OXALIPLATIN HUMAN PRESCRIPTION DRUG LABEL 1 0955-1727 INJECTION, SOLUTION, CONCENTRATE 5 mg INTRAVENOUS NDA AUTHORIZED GENERIC 33 sections
OXALIPLATIN HUMAN PRESCRIPTION DRUG LABEL 1 0955-1731 INJECTION, SOLUTION, CONCENTRATE 5 mg INTRAVENOUS NDA AUTHORIZED GENERIC 33 sections
OXALIPLATIN HUMAN PRESCRIPTION DRUG LABEL 1 0955-1731 INJECTION, SOLUTION, CONCENTRATE 5 mg INTRAVENOUS NDA AUTHORIZED GENERIC 33 sections
OXALIPLATIN HUMAN PRESCRIPTION DRUG LABEL 1 0955-1733 INJECTION, SOLUTION, CONCENTRATE 5 mg INTRAVENOUS NDA AUTHORIZED GENERIC 33 sections
OXALIPLATIN HUMAN PRESCRIPTION DRUG LABEL 1 0955-1733 INJECTION, SOLUTION, CONCENTRATE 5 mg INTRAVENOUS NDA AUTHORIZED GENERIC 33 sections
oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 16714-727 INJECTION 5 mg INTRAVENOUS ANDA 27 sections
oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 16714-728 INJECTION 5 mg INTRAVENOUS ANDA 27 sections
oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 16729-332 INJECTION, SOLUTION, CONCENTRATE 5 mg INTRAVENOUS ANDA 30 sections
oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 25021-233 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 28 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 43066-014 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 28 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 43066-018 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 28 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 45963-611 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 5 mg INTRAVENOUS ANDA 20 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 45963-611 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 5 mg INTRAVENOUS ANDA 20 sections
Oxaliplatin Human Prescription Drug Label 1 47335-046 INJECTION, SOLUTION, CONCENTRATE 50 mg INTRAVENOUS ANDA 27 sections
Oxaliplatin Human Prescription Drug Label 1 47335-047 INJECTION, SOLUTION, CONCENTRATE 100 mg INTRAVENOUS ANDA 27 sections
Oxaliplatin Human Prescription Drug Label 1 47335-176 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 50 mg INTRAVENOUS ANDA 28 sections
Oxaliplatin Human Prescription Drug Label 1 47335-178 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS ANDA 28 sections