oxaliplatin ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antineoplastic agents, platinum derivatives 4210 61825-94-3

Description:

MoleculeDescription

Synonyms:

  • oxaliplatin
  • oxalatoplatin
  • oxalatoplatinum
An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS.
  • Molecular weight: 397.29
  • Formula: C8H14N2O4Pt
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 6 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 8.13 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.50 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.13 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 58.92 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 9, 2002 FDA
March 18, 2005 PMDA Yakult Honsha

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuropathy peripheral 992.43 17.06 835 55122 95922 50453245
Laryngospasm 906.12 17.06 260 55697 2428 50546739
Neutropenia 900.85 17.06 956 55001 147009 50402158
Neurotoxicity 664.79 17.06 325 55632 14415 50534752
Thrombocytopenia 640.35 17.06 746 55211 126927 50422240
Diarrhoea 565.12 17.06 1671 54286 586805 49962362
Disease progression 548.26 17.06 600 55357 95266 50453901
Mucosal inflammation 445.12 17.06 363 55594 39779 50509388
Palmar-plantar erythrodysaesthesia syndrome 414.58 17.06 265 55692 19833 50529334
Paraesthesia 400.23 17.06 574 55383 119669 50429498
Vomiting 378.16 17.06 1241 54716 459517 50089650
Drug ineffective 315.23 17.06 268 55689 819065 49730102
Bone marrow failure 312.87 17.06 253 55704 27371 50521796
Dysarthria 301.21 17.06 282 55675 37121 50512046
Stridor 300.60 17.06 118 55839 3051 50546116
Dermatitis acneiform 295.53 17.06 125 55832 3932 50545235
Peripheral sensory neuropathy 287.13 17.06 142 55815 6449 50542718
Bronchospasm 282.09 17.06 186 55771 14668 50534499
Throat tightness 277.33 17.06 210 55747 20637 50528530
Myelosuppression 258.49 17.06 170 55787 13347 50535820
Polyneuropathy 250.23 17.06 160 55797 11971 50537196
Arthralgia 244.89 17.06 90 55867 438612 50110555
Dysaesthesia pharynx 242.02 17.06 51 55906 97 50549070
Skin toxicity 240.68 17.06 107 55850 3806 50545361
Nausea 215.70 17.06 1422 54535 703976 49845191
Joint swelling 207.72 17.06 17 55940 245269 50303898
Arteriospasm coronary 202.75 17.06 91 55866 3311 50545856
Febrile neutropenia 201.70 17.06 376 55581 97291 50451876
Gastrointestinal toxicity 198.49 17.06 99 55858 4578 50544589
Metastases to liver 190.16 17.06 166 55791 19938 50529229
Haematotoxicity 187.75 17.06 114 55843 7781 50541386
Gastrointestinal perforation 186.01 17.06 83 55874 2978 50546189
Headache 181.69 17.06 176 55781 506359 50042808
Pain 172.13 17.06 234 55723 578669 49970498
Neutrophil count decreased 168.10 17.06 230 55727 45796 50503371
Product dose omission issue 166.56 17.06 9 55948 183829 50365338
Leukopenia 166.46 17.06 281 55676 67247 50481920
Posterior reversible encephalopathy syndrome 163.24 17.06 134 55823 14794 50534373
Malignant neoplasm progression 159.39 17.06 277 55680 67847 50481320
Arthropathy 155.76 17.06 4 55953 157902 50391265
Sinusitis 155.61 17.06 8 55949 170550 50378617
Swelling 154.33 17.06 20 55937 200852 50348315
Enteritis 153.59 17.06 96 55861 6899 50542268
Dyspnoea 148.39 17.06 1073 54884 546535 50002632
Erythema 147.70 17.06 425 55532 145989 50403178
Weight increased 143.86 17.06 25 55932 201866 50347301
Non-cirrhotic portal hypertension 142.53 17.06 34 55923 138 50549029
Dehydration 139.04 17.06 427 55530 152022 50397145
Nasopharyngitis 137.22 17.06 24 55933 192903 50356264
Contraindicated product administered 135.83 17.06 7 55950 148951 50400216
Systemic lupus erythematosus 133.51 17.06 5 55952 140617 50408550
Maternal exposure during pregnancy 127.42 17.06 14 55943 159764 50389403
Venoocclusive liver disease 123.64 17.06 70 55887 4191 50544976
Portal hypertension 121.35 17.06 64 55893 3328 50545839
Abdominal pain 119.24 17.06 547 55410 235681 50313486
Fall 119.11 17.06 117 55840 334815 50214352
Pemphigus 118.65 17.06 3 55954 120163 50429004
Laryngeal oedema 117.67 17.06 72 55885 4981 50544186
Ascites 115.81 17.06 169 55788 35692 50513475
Abdominal discomfort 113.84 17.06 57 55900 231584 50317583
Chills 113.69 17.06 297 55660 96390 50452777
Anaphylactic shock 111.20 17.06 124 55833 20031 50529136
Hyperammonaemia 109.21 17.06 67 55890 4657 50544510
Paronychia 108.76 17.06 66 55891 4498 50544669
Peripheral swelling 108.44 17.06 46 55911 205890 50343277
Glossodynia 106.72 17.06 5 55952 115564 50433603
Therapeutic product effect decreased 105.78 17.06 13 55944 136037 50413130
Dysphonia 105.44 17.06 169 55788 38723 50510444
Immune thrombocytopenia 105.04 17.06 84 55873 8933 50540234
Depression 104.48 17.06 27 55930 165396 50383771
Splenomegaly 104.11 17.06 86 55871 9574 50539593
Dysaesthesia 102.05 17.06 59 55898 3676 50545491
Insomnia 98.76 17.06 35 55922 174830 50374337
Paraesthesia oral 98.03 17.06 92 55865 12129 50537038
Wound 96.33 17.06 5 55952 105789 50443378
Speech disorder 94.35 17.06 153 55804 35395 50513772
Colorectal cancer metastatic 93.49 17.06 31 55926 484 50548683
Product use issue 91.37 17.06 26 55931 149449 50399718
Focal nodular hyperplasia 90.55 17.06 30 55927 467 50548700
Tongue oedema 90.16 17.06 55 55902 3784 50545383
Intestinal perforation 90.09 17.06 82 55875 10397 50538770
Intestinal obstruction 89.07 17.06 127 55830 26256 50522911
Bronchitis 88.68 17.06 7 55950 104152 50445015
Stomatitis 87.80 17.06 279 55678 101065 50448102
Large intestine perforation 87.69 17.06 70 55887 7424 50541743
Nodular regenerative hyperplasia 85.81 17.06 25 55932 247 50548920
Lower respiratory tract infection 85.12 17.06 5 55952 95196 50453971
Metastases to lung 84.66 17.06 81 55876 10939 50538228
Anaemia 83.78 17.06 521 55436 251935 50297232
Cardiotoxicity 83.00 17.06 66 55891 6961 50542206
Neuromyotonia 82.63 17.06 18 55939 43 50549124
Asthma 82.04 17.06 4 55953 89333 50459834
Decreased appetite 80.53 17.06 436 55521 200487 50348680
Dysphagia 79.00 17.06 226 55731 77292 50471875
Hypomagnesaemia 77.48 17.06 111 55846 23045 50526122
Drug intolerance 77.26 17.06 77 55880 219027 50330140
Asthenia 76.87 17.06 609 55348 318433 50230734
Stress cardiomyopathy 76.33 17.06 66 55891 7821 50541346
Influenza 76.26 17.06 6 55951 89532 50459635
Hypokalaemia 75.99 17.06 242 55715 87750 50461417
Flushing 75.83 17.06 203 55754 66812 50482355
Laryngeal discomfort 71.80 17.06 22 55935 262 50548905
Injection site pain 70.31 17.06 18 55939 111006 50438161
Metastases to peritoneum 70.17 17.06 42 55915 2791 50546376
Therapy partial responder 69.62 17.06 58 55899 6533 50542634
Pain in extremity 69.54 17.06 122 55835 272743 50276424
Exposure during pregnancy 68.68 17.06 24 55933 120991 50428176
Anastomotic leak 67.44 17.06 23 55934 393 50548774
Condition aggravated 66.86 17.06 143 55814 296915 50252252
Hyperammonaemic encephalopathy 66.67 17.06 36 55921 1963 50547204
Pyrexia 65.12 17.06 674 55283 379529 50169638
Hypertension 64.54 17.06 427 55530 210776 50338391
Musculoskeletal stiffness 63.99 17.06 31 55926 128450 50420717
Ileus 63.89 17.06 76 55881 13153 50536014
Haemolytic anaemia 63.37 17.06 64 55893 9228 50539939
Arthritis 63.35 17.06 10 55947 86711 50462456
Drug hypersensitivity 63.25 17.06 113 55844 250897 50298270
Hospitalisation 62.51 17.06 3 55954 67934 50481233
Pericarditis 62.43 17.06 7 55950 78682 50470485
Contusion 62.38 17.06 23 55934 112160 50437007
Platelet count decreased 62.07 17.06 248 55709 100478 50448689
Oxygen saturation decreased 61.91 17.06 200 55757 73048 50476119
Hepatic enzyme increased 61.37 17.06 38 55919 137342 50411825
Injection site erythema 61.16 17.06 6 55951 74930 50474237
General physical health deterioration 60.37 17.06 314 55643 142120 50407047
Hyperhidrosis 59.84 17.06 226 55731 89200 50459967
Peritonitis 58.95 17.06 79 55878 15407 50533760
Interstitial lung disease 58.06 17.06 159 55798 53017 50496150
Tumour perforation 57.21 17.06 15 55942 96 50549071
Cardiac failure congestive 56.75 17.06 12 55945 84370 50464797
Anaphylactic reaction 56.42 17.06 159 55798 53896 50495271
Hyperthermia 56.17 17.06 55 55902 7641 50541526
Hypertensive crisis 56.14 17.06 71 55886 13083 50536084
Enterocutaneous fistula 56.03 17.06 27 55930 1157 50548010
Chemical peritonitis 53.75 17.06 14 55943 87 50549080
Treatment failure 53.70 17.06 44 55913 137593 50411574
Alopecia 53.43 17.06 120 55837 244927 50304240
Enterocolitis 51.83 17.06 49 55908 6518 50542649
Neoplasm progression 51.27 17.06 105 55852 29052 50520115
Drug abuse 50.99 17.06 4 55953 59842 50489325
Metastases to meninges 50.42 17.06 30 55927 1972 50547195
Feeling hot 49.73 17.06 124 55833 39078 50510089
Hydronephrosis 49.62 17.06 54 55903 8487 50540680
Suicidal ideation 49.22 17.06 3 55954 55382 50493785
Gait disturbance 49.17 17.06 56 55901 149949 50399218
Diffuse large B-cell lymphoma recurrent 48.44 17.06 27 55930 1568 50547599
Colitis 47.96 17.06 121 55836 38408 50510759
Neutropenic colitis 47.66 17.06 31 55926 2386 50546781
Drug interaction 47.49 17.06 93 55864 199528 50349639
Somnolence 47.47 17.06 61 55896 154924 50394243
Blood lactate dehydrogenase abnormal 47.14 17.06 15 55942 204 50548963
Rectal perforation 46.11 17.06 17 55940 368 50548799
Band sensation 46.09 17.06 20 55937 670 50548497
Varices oesophageal 45.96 17.06 32 55925 2757 50546410
Disseminated intravascular coagulation 45.79 17.06 74 55883 17061 50532106
Suicide attempt 45.39 17.06 3 55954 51729 50497438
Pneumonia 45.30 17.06 240 55717 378161 50171006
Extravasation 45.27 17.06 28 55929 1974 50547193
Upper respiratory tract infection 45.08 17.06 9 55948 65889 50483278
Evans syndrome 44.93 17.06 14 55943 177 50548990
Off label use 44.23 17.06 753 55204 473673 50075494
Diffuse large B-cell lymphoma refractory 43.96 17.06 22 55935 1024 50548143
Cough 43.49 17.06 130 55827 241134 50308033
Proteinuria 43.44 17.06 71 55886 16526 50532641
Suffocation feeling 43.30 17.06 23 55934 1213 50547954
Helicobacter infection 43.26 17.06 3 55954 49699 50499468
Hypertransaminasaemia 42.82 17.06 34 55923 3577 50545590
Cholinergic syndrome 42.58 17.06 16 55941 366 50548801
Injury 42.45 17.06 3 55954 48922 50500245
Steatohepatitis 42.43 17.06 17 55940 464 50548703
Neutrophil count abnormal 42.37 17.06 29 55928 2430 50546737
Choking sensation 42.19 17.06 32 55925 3148 50546019
Carcinoembryonic antigen increased 42.18 17.06 24 55933 1450 50547717
Stress 42.13 17.06 5 55952 53788 50495379
Dihydropyrimidine dehydrogenase deficiency 42.01 17.06 11 55946 70 50549097
Mucosal toxicity 41.47 17.06 15 55942 307 50548860
Overdose 41.28 17.06 30 55927 99697 50449470
Cold dysaesthesia 40.93 17.06 8 55949 8 50549159
Injection site reaction 40.84 17.06 4 55953 50028 50499139
Hepatic failure 40.83 17.06 102 55855 32181 50516986
Cataract 40.75 17.06 3 55954 47297 50501870
Splenic artery thrombosis 40.73 17.06 10 55947 47 50549120
Factor VII deficiency 40.34 17.06 9 55948 25 50549142
Sensation of foreign body 40.25 17.06 34 55923 3902 50545265
Intentional product misuse 40.16 17.06 3 55954 46731 50502436
Anxiety 39.48 17.06 86 55871 177520 50371647
Chronic obstructive pulmonary disease 39.39 17.06 6 55951 53429 50495738
Acute coronary syndrome 39.06 17.06 50 55907 9324 50539843
Duodenal ulcer perforation 38.99 17.06 3 55954 45608 50503559
Tachycardia 38.88 17.06 215 55742 99548 50449619
Hypertrichosis 38.84 17.06 20 55937 989 50548178
Cardiac ventricular thrombosis 38.84 17.06 16 55941 470 50548697
Acute polyneuropathy 38.79 17.06 13 55944 210 50548957
White blood cell count decreased 38.68 17.06 241 55716 116481 50432686
Leukoencephalopathy 38.60 17.06 33 55924 3850 50545317
Tremor 38.55 17.06 238 55719 114665 50434502
Cystitis radiation 38.41 17.06 10 55947 62 50549105
Discomfort 38.26 17.06 38 55919 108342 50440825
Short-bowel syndrome 38.09 17.06 15 55942 391 50548776
Infusion related hypersensitivity reaction 38.01 17.06 10 55947 65 50549102
Bladder tamponade 37.24 17.06 10 55947 71 50549096
Atypical haemolytic uraemic syndrome 36.73 17.06 16 55941 541 50548626
Formication 36.27 17.06 31 55926 3615 50545552
Female genital tract fistula 36.13 17.06 31 55926 3635 50545532
Fatigue 35.92 17.06 559 55398 707042 49842125
Cytokine release syndrome 35.89 17.06 46 55911 8588 50540579
Osteoporosis 35.57 17.06 4 55953 44875 50504292
Pancytopenia 35.39 17.06 185 55772 83845 50465322
Ileal perforation 35.19 17.06 14 55943 375 50548792
Multiple organ dysfunction syndrome 35.14 17.06 129 55828 50208 50498959
Laryngeal dyspnoea 35.02 17.06 11 55946 143 50549024
Thrombocytopenic purpura 34.89 17.06 20 55937 1226 50547941
Large intestinal obstruction 34.72 17.06 23 55934 1826 50547341
Pharyngeal paraesthesia 34.38 17.06 21 55936 1448 50547719
Hypoalbuminaemia 34.06 17.06 48 55909 9812 50539355
Blister 33.68 17.06 27 55930 85391 50463776
Injection site pruritus 33.60 17.06 3 55954 40408 50508759
ECG signs of myocardial ischaemia 33.39 17.06 9 55948 65 50549102
Migraine 33.35 17.06 21 55936 75259 50473908
Mobility decreased 33.15 17.06 24 55933 79924 50469243
Muscle spasms 33.09 17.06 245 55712 125308 50423859
Metastases to spleen 32.72 17.06 10 55947 118 50549049
Memory impairment 32.67 17.06 24 55933 79336 50469831
Abortion spontaneous 32.42 17.06 4 55953 41768 50507399
Incorrect dose administered 32.31 17.06 7 55950 48407 50500760
Anastomotic fistula 32.05 17.06 7 55950 17 50549150
Muscle rigidity 31.25 17.06 46 55911 9783 50539384
Nicotinic acid deficiency 31.24 17.06 8 55949 46 50549121
Myalgia 31.24 17.06 56 55901 124263 50424904
Tumour ulceration 31.16 17.06 10 55947 140 50549027
Motion sickness 31.13 17.06 16 55941 788 50548379
Ocular toxicity 30.64 17.06 14 55943 531 50548636
Vascular pain 30.59 17.06 15 55942 668 50548499
Infection 30.57 17.06 94 55863 172860 50376307
Catheter site bruise 30.42 17.06 12 55945 314 50548853
Metastases to ovary 29.60 17.06 12 55945 338 50548829
Metastasis 29.59 17.06 30 55927 4345 50544822
Gastric perforation 29.34 17.06 19 55938 1451 50547716
Paraphilia 29.04 17.06 5 55952 0 50549167
Oropharyngeal discomfort 28.95 17.06 28 55929 3830 50545337
Subileus 28.56 17.06 24 55933 2735 50546432
Hemiparaesthesia 28.53 17.06 8 55949 68 50549099
Perforation 28.41 17.06 16 55941 948 50548219
Herpes zoster 28.38 17.06 22 55935 70764 50478403
Pulmonary embolism 28.25 17.06 201 55756 101503 50447664
Dysgeusia 28.23 17.06 101 55856 38815 50510352
Wrong technique in product usage process 28.22 17.06 13 55944 55497 50493670
Skin fissures 28.18 17.06 41 55916 8627 50540540
Haemolysis 28.13 17.06 34 55923 5982 50543185
Inappropriate schedule of product administration 27.95 17.06 23 55934 71808 50477359
Lip oedema 27.47 17.06 25 55932 3168 50545999
Type 2 diabetes mellitus 27.40 17.06 3 55954 34372 50514795
Tonic clonic movements 27.21 17.06 17 55940 1220 50547947
Hemiparesis 27.11 17.06 65 55892 19983 50529184
K-ras gene mutation 27.07 17.06 6 55951 16 50549151
Left ventricular failure 27.07 17.06 30 55927 4811 50544356
Metastases to lymph nodes 26.99 17.06 36 55921 6988 50542179
Inferior vena cava stenosis 26.81 17.06 6 55951 17 50549150
Sleep disorder 26.76 17.06 15 55942 57268 50491899
Medical device site extravasation 26.70 17.06 5 55952 3 50549164
Cholangitis 26.68 17.06 29 55928 4550 50544617
Tumour necrosis 26.68 17.06 14 55943 720 50548447
Trismus 26.46 17.06 25 55932 3323 50545844
Hypophagia 26.45 17.06 79 55878 27649 50521518
Blood pressure fluctuation 26.45 17.06 4 55953 35819 50513348
Cardiospasm 26.31 17.06 6 55951 19 50549148
Feeling abnormal 26.07 17.06 63 55894 125429 50423738
Palmar erythema 25.91 17.06 18 55939 1545 50547622
White blood cell count abnormal 25.85 17.06 31 55926 5409 50543758
Gastric varices haemorrhage 25.61 17.06 8 55949 102 50549065
Schistosomiasis 25.58 17.06 5 55952 5 50549162
Haematemesis 25.52 17.06 78 55879 27647 50521520
Gastrointestinal anastomotic leak 25.36 17.06 9 55948 174 50548993
Rhabdomyolysis 25.33 17.06 6 55951 39021 50510146
Catabolic state 25.23 17.06 7 55950 57 50549110
Type I hypersensitivity 25.21 17.06 21 55936 2364 50546803
Urinary tract infection 25.15 17.06 145 55812 223875 50325292
Peripheral motor neuropathy 24.95 17.06 17 55940 1414 50547753
Metastases to bone marrow 24.92 17.06 10 55947 274 50548893
Aortic intramural haematoma 24.81 17.06 7 55950 61 50549106
Soft tissue necrosis 24.72 17.06 11 55946 392 50548775
Monoparesis 24.60 17.06 17 55940 1447 50547720
Myopathy toxic 24.56 17.06 11 55946 398 50548769
Hyperpyrexia 24.54 17.06 23 55934 3026 50546141
Influenza like illness 24.14 17.06 17 55940 57442 50491725
Administration site extravasation 24.09 17.06 13 55944 708 50548459
Dizziness 24.01 17.06 256 55701 346113 50203054
Metastases to diaphragm 23.97 17.06 6 55951 31 50549136
Hepatocellular injury 23.88 17.06 73 55884 25874 50523293
Hepatic function abnormal 23.86 17.06 85 55872 32596 50516571
Inflammation 23.70 17.06 17 55940 56895 50492272
Folliculitis 23.62 17.06 7 55950 39218 50509949
Type II hypersensitivity 23.56 17.06 5 55952 10 50549157
Skin reaction 23.16 17.06 44 55913 11524 50537643
Treatment noncompliance 23.12 17.06 3 55954 30147 50519020
Hypocapnia 22.93 17.06 10 55947 339 50548828
Productive cough 22.93 17.06 15 55942 52679 50496488
Cyanosis 22.46 17.06 51 55906 15133 50534034
Portal shunt 22.38 17.06 5 55952 14 50549153
Implant site dehiscence 22.38 17.06 5 55952 14 50549153
Subacute cutaneous lupus erythematosus 22.38 17.06 19 55938 2196 50546971
Oesophageal varices haemorrhage 22.27 17.06 14 55943 1016 50548151
Chest discomfort 22.22 17.06 177 55780 92545 50456622
Colon cancer metastatic 22.14 17.06 14 55943 1026 50548141
COVID-19 22.11 17.06 12 55945 46650 50502517
Loss of personal independence in daily activities 22.03 17.06 27 55930 70023 50479144
Gastrointestinal stoma complication 21.83 17.06 16 55941 1494 50547673
Rectal cancer recurrent 21.65 17.06 5 55952 17 50549150
Small intestinal obstruction 21.62 17.06 52 55905 16016 50533151
Haemolytic uraemic syndrome 21.62 17.06 19 55938 2300 50546867
Unevaluable event 21.60 17.06 12 55945 46054 50503113
Hypotension 21.57 17.06 373 55584 235096 50314071
Sedation 21.31 17.06 4 55953 30606 50518561
Hyperventilation 21.21 17.06 28 55929 5381 50543786
Eyelid ptosis 21.19 17.06 30 55927 6157 50543010
Respiratory distress 21.16 17.06 78 55879 30411 50518756
Adverse drug reaction 21.09 17.06 18 55939 55204 50493963
Infusion related reaction 21.09 17.06 283 55674 169274 50379893
Respiratory fatigue 21.01 17.06 7 55950 111 50549056
Lacrimation disorder 21.00 17.06 4 55953 3 50549164
Hepatic encephalopathy 20.98 17.06 38 55919 9598 50539569
Blood glucose increased 20.88 17.06 29 55928 71295 50477872
Renal tubular disorder 20.81 17.06 19 55938 2418 50546749
Impaired healing 20.80 17.06 28 55929 69758 50479409
Toxic encephalopathy 20.78 17.06 28 55929 5487 50543680
Ileus paralytic 20.77 17.06 24 55933 4026 50545141
Biliary tract infection 20.72 17.06 10 55947 430 50548737
Dyslalia 20.63 17.06 10 55947 434 50548733
Coronary artery disease 20.45 17.06 4 55953 29722 50519445
Pelvic fluid collection 20.42 17.06 12 55945 771 50548396
Balance disorder 20.36 17.06 29 55928 70561 50478606
Nasal congestion 20.35 17.06 16 55941 51104 50498063
Colitis ischaemic 20.15 17.06 37 55920 9446 50539721
Granulocyte count decreased 20.09 17.06 12 55945 794 50548373
Encapsulating peritoneal sclerosis 20.01 17.06 9 55948 329 50548838
Confusional state 19.99 17.06 122 55835 185806 50363361
Diabetes mellitus 19.96 17.06 15 55942 49018 50500149
Portal vein dilatation 19.95 17.06 5 55952 26 50549141
Paralysis 19.93 17.06 35 55922 8629 50540538
Sputum abnormal 19.85 17.06 10 55947 472 50548695
Colorectal cancer recurrent 19.58 17.06 4 55953 6 50549161
Rhinorrhoea 19.47 17.06 17 55940 51566 50497601
Heart rate decreased 19.42 17.06 8 55949 36489 50512678
Oral dysaesthesia 19.39 17.06 6 55951 74 50549093
Subclavian vein thrombosis 19.35 17.06 16 55941 1783 50547384
Drug reaction with eosinophilia and systemic symptoms 19.19 17.06 4 55953 28420 50520747
Hyperlipasaemia 19.10 17.06 10 55947 512 50548655
Disease recurrence 18.95 17.06 57 55900 20024 50529143
Hepatic vein stenosis 18.94 17.06 5 55952 33 50549134
Dry eye 18.83 17.06 6 55951 32089 50517078
Tongue discomfort 18.82 17.06 16 55941 1852 50547315
Aortic dissection 18.81 17.06 15 55942 1588 50547579
Hereditary motor and sensory neuropathy 18.76 17.06 6 55951 83 50549084
Viral infection 18.71 17.06 5 55952 29981 50519186
Gastrooesophageal reflux disease 18.68 17.06 35 55922 76393 50472774
Hyperbilirubinaemia 18.67 17.06 36 55921 9534 50539633
Red cell fragmentation syndrome 18.56 17.06 5 55952 36 50549131
Peripheral nerve injury 18.52 17.06 9 55948 393 50548774
Hypervolaemia 18.48 17.06 3 55954 25496 50523671
Encephalopathy 18.39 17.06 80 55877 33631 50515536
Stoma site haemorrhage 18.38 17.06 12 55945 929 50548238
Diaphragmatic paralysis 18.36 17.06 10 55947 555 50548612
Hypersensitivity 18.34 17.06 337 55620 214824 50334343
Gastrointestinal inflammation 18.33 17.06 24 55933 4576 50544591
Adverse event 18.32 17.06 13 55944 43750 50505417
Trichomegaly 17.99 17.06 5 55952 41 50549126
Jaw operation 17.87 17.06 11 55946 769 50548398
Aortic thrombosis 17.84 17.06 12 55945 977 50548190
Congestive cardiomyopathy 17.79 17.06 26 55931 5492 50543675
Duodenal ulcer 17.75 17.06 29 55928 6746 50542421
Retching 17.71 17.06 42 55915 12820 50536347
Endometrial dysplasia 17.70 17.06 4 55953 12 50549155
Weight decreased 17.63 17.06 158 55799 221087 50328080
Respiratory failure 17.63 17.06 166 55791 91015 50458152
Appendicitis noninfective 17.43 17.06 3 55954 0 50549167
Road traffic accident 17.35 17.06 3 55954 24349 50524818
Hypothyroidism 17.33 17.06 8 55949 34117 50515050
Femoral artery embolism 17.29 17.06 5 55952 48 50549119
Acute respiratory distress syndrome 17.26 17.06 57 55900 21042 50528125
Femur fracture 17.22 17.06 10 55947 37454 50511713
Gastrointestinal stoma output increased 17.21 17.06 7 55950 199 50548968
Pneumatosis intestinalis 17.19 17.06 16 55941 2087 50547080
Pigmentation disorder 17.15 17.06 21 55936 3743 50545424
Embolism 17.15 17.06 29 55928 6939 50542228
Surgery 17.11 17.06 6 55951 30199 50518968
Pulmonary artery thrombosis 17.09 17.06 10 55947 637 50548530

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuropathy peripheral 1212.37 15.09 1190 76164 69837 29427336
Disease progression 661.72 15.09 936 76418 80980 29416193
Neurotoxicity 635.48 15.09 424 76930 14189 29482984
Diarrhoea 628.39 15.09 2098 75256 330600 29166573
Neutropenia 602.08 15.09 1164 76190 130547 29366626
Palmar-plantar erythrodysaesthesia syndrome 558.36 15.09 393 76961 14366 29482807
Dermatitis acneiform 536.92 15.09 270 77084 5221 29491952
Skin toxicity 485.67 15.09 224 77130 3547 29493626
Thrombocytopenia 453.67 15.09 1052 76302 133771 29363402
Arteriospasm coronary 448.86 15.09 189 77165 2376 29494797
Paronychia 329.78 15.09 159 77195 2794 29494379
Vomiting 327.78 15.09 1256 76098 211004 29286169
Erythema 317.78 15.09 646 76708 74960 29422213
Metastases to liver 315.72 15.09 256 77098 11600 29485573
Interstitial lung disease 311.78 15.09 549 76805 57169 29440004
Peripheral sensory neuropathy 284.08 15.09 183 77171 5756 29491417
Paraesthesia 279.01 15.09 503 76851 53342 29443831
Nausea 277.18 15.09 1486 75868 287769 29209404
Venoocclusive liver disease 258.73 15.09 183 77171 6734 29490439
Mucosal inflammation 255.88 15.09 362 76992 31233 29465940
Gastrointestinal perforation 238.16 15.09 135 77219 3348 29493825
Polyneuropathy 237.64 15.09 220 77134 11932 29485241
Drug ineffective 235.14 15.09 368 76986 362802 29134371
Portal hypertension 232.67 15.09 133 77221 3353 29493820
Bone marrow failure 231.94 15.09 321 77033 27128 29470045
Myelosuppression 221.18 15.09 212 77142 12015 29485158
Chills 220.36 15.09 539 76815 70761 29426412
Completed suicide 220.30 15.09 3 77351 90243 29406930
Product dose omission issue 213.49 15.09 9 77345 96374 29400799
Hypersensitivity 196.48 15.09 430 76924 52473 29444700
Arthralgia 193.83 15.09 62 77292 139555 29357618
Stomatitis 193.79 15.09 348 77006 36765 29460408
Haematotoxicity 191.87 15.09 151 77203 6548 29490625
Enteritis 183.65 15.09 148 77206 6643 29490530
Fall 170.18 15.09 129 77225 177049 29320124
Metastases to lung 166.87 15.09 149 77205 7706 29489467
Gastrointestinal toxicity 165.98 15.09 90 77264 2041 29495132
Drug interaction 165.01 15.09 164 77190 197221 29299952
Laryngospasm 157.91 15.09 74 77280 1216 29495957
Bronchospasm 152.23 15.09 155 77199 9454 29487719
Abdominal pain 148.15 15.09 723 76631 134634 29362539
Headache 144.89 15.09 145 77209 173862 29323311
Hyperammonaemic encephalopathy 141.11 15.09 79 77275 1911 29495262
Flushing 140.14 15.09 263 77091 28729 29468444
Overdose 139.77 15.09 21 77333 79798 29417375
Focal nodular hyperplasia 139.51 15.09 39 77315 116 29497057
Pneumonia 136.53 15.09 409 76945 319763 29177410
Decreased appetite 133.89 15.09 740 76614 144602 29352571
Cardiotoxicity 131.70 15.09 105 77249 4639 29492534
Carcinoembryonic antigen increased 129.64 15.09 52 77302 572 29496601
Dysaesthesia pharynx 122.52 15.09 29 77325 31 29497142
Feeling hot 121.69 15.09 175 77179 15313 29481860
Proteinuria 117.54 15.09 174 77180 15630 29481543
Hyperammonaemia 117.47 15.09 106 77248 5557 29491616
Hypomagnesaemia 116.75 15.09 183 77171 17285 29479888
Neutrophil count decreased 107.50 15.09 303 77051 43264 29453909
Cardiac failure congestive 106.18 15.09 34 77320 76547 29420626
Leukopenia 104.56 15.09 350 77004 54853 29442320
Skin reaction 104.30 15.09 89 77265 4328 29492845
Infusion related reaction 104.19 15.09 301 77053 43585 29453588
Dehydration 104.08 15.09 582 76772 114166 29383007
Intravascular haemolysis 102.05 15.09 39 77315 373 29496800
Pyrexia 100.59 15.09 1171 76183 286451 29210722
Ascites 98.62 15.09 263 77091 36356 29460817
Intestinal obstruction 98.32 15.09 179 77175 19098 29478075
Depression 96.72 15.09 51 77303 85096 29412077
Insomnia 93.91 15.09 58 77296 88703 29408470
Oxygen saturation decreased 92.37 15.09 293 77061 44644 29452529
Therapy partial responder 91.84 15.09 89 77265 5110 29492063
Anastomotic leak 88.13 15.09 39 77315 557 29496616
Varices oesophageal 88.12 15.09 70 77284 3076 29494097
Hospitalisation 88.03 15.09 9 77345 45979 29451194
Anastomotic complication 86.31 15.09 33 77321 316 29496857
Anxiety 85.93 15.09 59 77295 85306 29411867
Myalgia 84.56 15.09 44 77310 73975 29423198
Metastases to peritoneum 83.12 15.09 51 77303 1469 29495704
Somnolence 83.12 15.09 74 77280 93881 29403292
Ileus 82.85 15.09 141 77213 14261 29482912
Anaphylactic shock 82.65 15.09 135 77219 13201 29483972
Tumour perforation 80.41 15.09 29 77325 232 29496941
Joint swelling 80.40 15.09 16 77338 49614 29447559
Peripheral swelling 78.77 15.09 34 77320 63705 29433468
Aggression 76.43 15.09 4 77350 35537 29461636
Rhabdomyolysis 75.84 15.09 32 77322 60776 29436397
Weight increased 74.52 15.09 55 77299 76612 29420561
Confusional state 73.67 15.09 139 77215 127738 29369435
Malignant neoplasm progression 73.23 15.09 384 76970 73475 29423698
Enterocolitis 71.93 15.09 88 77266 6578 29490595
Large intestine perforation 69.68 15.09 91 77263 7265 29489908
Type I hypersensitivity 69.13 15.09 40 77314 1032 29496141
Diffuse large B-cell lymphoma recurrent 68.94 15.09 56 77298 2541 29494632
Influenza 68.90 15.09 13 77341 41868 29455305
Inappropriate schedule of product administration 68.64 15.09 16 77338 44456 29452717
Peritonitis 68.54 15.09 132 77222 14692 29482481
Portal shunt 68.04 15.09 17 77337 27 29497146
Toxic leukoencephalopathy 67.46 15.09 26 77328 255 29496918
Dihydropyrimidine dehydrogenase deficiency 67.11 15.09 19 77335 60 29497113
Incorrect dose administered 67.07 15.09 5 77349 32979 29464194
Pneumatosis intestinalis 67.07 15.09 60 77294 3109 29494064
Tumour necrosis 66.94 15.09 40 77314 1097 29496076
Extravasation 66.63 15.09 46 77308 1626 29495547
Disseminated intravascular coagulation 65.85 15.09 155 77199 19825 29477348
Injection site pain 65.75 15.09 5 77349 32441 29464732
Vascular pain 65.15 15.09 21 77333 114 29497059
Stomal varices 64.58 15.09 17 77337 37 29497136
Hallucination 63.48 15.09 19 77335 44693 29452480
Myocardial infarction 63.41 15.09 120 77234 110176 29386997
Neoplasm progression 63.10 15.09 146 77208 18466 29478707
Non-cirrhotic portal hypertension 62.57 15.09 24 77330 232 29496941
Contusion 62.42 15.09 5 77349 31090 29466083
Blood glucose increased 61.73 15.09 39 77315 58945 29438228
Rectal perforation 61.62 15.09 27 77327 376 29496797
Suicidal ideation 61.04 15.09 9 77345 34707 29462466
Hepatic atrophy 59.92 15.09 21 77333 153 29497020
Electrocardiogram QT prolonged 59.90 15.09 11 77343 36126 29461047
Electrocardiogram ST segment elevation 59.68 15.09 66 77288 4426 29492747
Product use issue 59.60 15.09 30 77324 51414 29445759
Paraesthesia oral 59.58 15.09 59 77295 3478 29493695
Pain in extremity 59.32 15.09 125 77229 110308 29386865
Nodular regenerative hyperplasia 59.26 15.09 31 77323 652 29496521
Hypertransaminasaemia 58.62 15.09 59 77295 3547 29493626
Metastases to lymph nodes 58.58 15.09 62 77292 3955 29493218
Memory impairment 58.56 15.09 12 77342 36458 29460715
Death 57.17 15.09 596 76758 341488 29155685
General physical health deterioration 57.10 15.09 462 76892 102395 29394778
Foetal exposure during pregnancy 56.81 15.09 10 77344 33857 29463316
Cholinergic syndrome 56.79 15.09 27 77327 459 29496714
Intestinal perforation 55.81 15.09 86 77268 8000 29489173
Colon cancer metastatic 54.71 15.09 39 77315 1452 29495721
Necrotising fasciitis 54.60 15.09 55 77299 3310 29493863
Laryngeal discomfort 54.39 15.09 19 77335 137 29497036
Tumour lysis syndrome 53.92 15.09 115 77239 13769 29483404
Coronary artery disease 53.91 15.09 24 77330 44166 29453007
Dysphonia 53.83 15.09 140 77214 19056 29478117
Hyperhidrosis 53.62 15.09 320 77034 64220 29432953
Colorectal cancer metastatic 53.11 15.09 27 77327 534 29496639
Administration site extravasation 52.95 15.09 26 77328 476 29496697
Palmar erythema 52.76 15.09 21 77333 226 29496947
Asthma 52.59 15.09 12 77342 33837 29463336
Toxicity to various agents 51.68 15.09 256 77098 173405 29323768
Pulmonary embolism 51.63 15.09 360 76994 76174 29420999
Hiccups 51.34 15.09 87 77267 8766 29488407
Agitation 50.89 15.09 36 77318 51268 29445905
Rash pustular 50.73 15.09 62 77292 4629 29492544
Feeling abnormal 50.42 15.09 41 77313 54404 29442769
Splenomegaly 49.29 15.09 108 77246 13171 29484002
Gastrointestinal anastomotic leak 48.21 15.09 22 77332 339 29496834
Cholangitis 47.65 15.09 77 77277 7460 29489713
Arthritis 47.60 15.09 5 77349 25014 29472159
Stoma site haemorrhage 46.89 15.09 27 77327 690 29496483
Therapeutic product effect decreased 46.64 15.09 10 77344 29441 29467732
Unevaluable event 45.55 15.09 11 77343 29840 29467333
Transdifferentiation of neoplasm 45.41 15.09 14 77340 64 29497109
Drug reaction with eosinophilia and systemic symptoms 45.38 15.09 9 77345 27983 29469190
Prinzmetal angina 44.89 15.09 28 77326 831 29496342
Malignant ascites 44.22 15.09 21 77333 356 29496817
Nasopharyngitis 43.77 15.09 55 77299 59610 29437563
Treatment noncompliance 43.25 15.09 6 77348 24221 29472952
Drug dependence 43.18 15.09 3 77351 20978 29476195
Anastomotic fistula 43.16 15.09 13 77341 54 29497119
Perforation 43.12 15.09 17 77337 178 29496995
Cellulitis 43.10 15.09 34 77320 45806 29451367
Asthenia 42.68 15.09 795 76559 214455 29282718
Febrile neutropenia 42.62 15.09 465 76889 111775 29385398
Enterovesical fistula 42.48 15.09 24 77330 591 29496582
Temperature intolerance 42.45 15.09 45 77309 2876 29494297
Evans syndrome 42.19 15.09 18 77336 234 29496939
Periportal sinus dilatation 42.09 15.09 11 77343 23 29497150
Intestinal ischaemia 41.80 15.09 68 77286 6624 29490549
Throat tightness 41.54 15.09 70 77284 7021 29490152
Nicotinic acid deficiency 40.57 15.09 13 77341 69 29497104
Dizziness 40.57 15.09 310 77044 189374 29307799
Septic shock 40.27 15.09 291 77063 62269 29434904
Chronic obstructive pulmonary disease 40.27 15.09 29 77325 40926 29456247
Subileus 39.82 15.09 43 77311 2807 29494366
Large intestinal obstruction 39.80 15.09 31 77323 1323 29495850
Oxygen saturation normal 39.59 15.09 8 77346 0 29497173
Noninfective epididymitis 39.59 15.09 8 77346 0 29497173
Hyperthermia 38.82 15.09 80 77274 9350 29487823
Immune thrombocytopenia 38.71 15.09 72 77282 7805 29489368
Pain 38.65 15.09 276 77078 171156 29326017
Small intestinal obstruction 38.42 15.09 97 77257 12964 29484209
Abnormal behaviour 38.41 15.09 7 77347 23120 29474053
Blood pressure immeasurable 38.19 15.09 25 77329 808 29496365
Dysaesthesia 37.92 15.09 36 77318 2014 29495159
Drug level increased 37.76 15.09 3 77351 18784 29478389
Off label use 37.68 15.09 1041 76313 299759 29197414
Neutropenic sepsis 37.58 15.09 90 77264 11637 29485536
Musculoskeletal stiffness 37.52 15.09 26 77328 37432 29459741
Influenza like illness 37.37 15.09 9 77345 24461 29472712
Sinusitis 36.92 15.09 22 77332 34328 29462845
Chronic kidney disease 36.84 15.09 25 77329 36391 29460782
Hypokalaemia 36.73 15.09 241 77113 49962 29447211
Liver function test abnormal 36.39 15.09 15 77339 28903 29468270
Hypoglycaemia 36.05 15.09 44 77310 48302 29448871
Acute coronary syndrome 35.69 15.09 91 77263 12234 29484939
International normalised ratio increased 35.67 15.09 38 77316 44334 29452839
Diabetes mellitus 35.64 15.09 31 77323 39800 29457373
Hepatic infarction 35.44 15.09 15 77339 191 29496982
Fluid retention 35.33 15.09 9 77345 23551 29473622
Stridor 34.92 15.09 36 77318 2227 29494946
Acute abdomen 34.86 15.09 32 77322 1715 29495458
Cardiac disorder 34.57 15.09 28 77326 37235 29459938
Cytomegalovirus infection 34.56 15.09 9 77345 23206 29473967
Tumour marker increased 34.29 15.09 20 77334 524 29496649
Psychotic disorder 34.15 15.09 6 77348 20348 29476825
Premature baby 34.07 15.09 3 77351 17277 29479896
Splenorenal shunt 34.07 15.09 8 77346 8 29497165
Wrong technique in product usage process 33.96 15.09 20 77334 31408 29465765
Cyanosis 33.48 15.09 84 77270 11183 29485990
Abdominal discomfort 33.24 15.09 46 77308 47857 29449316
Blood pressure fluctuation 33.09 15.09 6 77348 19888 29477285
Condition aggravated 32.73 15.09 236 77118 146059 29351114
Bronchitis 32.62 15.09 29 77325 36839 29460334
Blood creatine phosphokinase increased 32.46 15.09 35 77319 40609 29456564
Performance status decreased 32.07 15.09 44 77310 3683 29493490
Pelvic abscess 31.92 15.09 23 77331 871 29496302
Hypoalbuminaemia 31.85 15.09 78 77276 10227 29486946
Leukoencephalopathy 31.70 15.09 44 77310 3723 29493450
Type II hypersensitivity 31.65 15.09 9 77345 29 29497144
Contraindicated product administered 31.50 15.09 5 77349 18261 29478912
Mobility decreased 31.44 15.09 14 77340 25766 29471407
Seizure 31.41 15.09 131 77223 92992 29404181
Herpes zoster 31.25 15.09 20 77334 30032 29467141
Portal venous gas 30.95 15.09 16 77338 328 29496845
Haematoma 30.94 15.09 11 77343 23201 29473972
Oesophageal haemorrhage 30.90 15.09 25 77329 1128 29496045
Pulmonary fibrosis 30.54 15.09 100 77254 15482 29481691
Metastasis 30.29 15.09 41 77313 3388 29493785
Right ventricular ejection fraction decreased 30.15 15.09 9 77345 36 29497137
Alopecia 30.09 15.09 114 77240 18970 29478203
Hyperaemia 29.95 15.09 23 77331 961 29496212
Haemolytic anaemia 29.87 15.09 72 77282 9347 29487826
Hypervolaemia 29.82 15.09 5 77349 17540 29479633
Biliary fistula 29.76 15.09 9 77345 38 29497135
Sciatic nerve palsy 29.76 15.09 9 77345 38 29497135
Carbohydrate antigen 19-9 increased 29.74 15.09 13 77341 180 29496993
Oesophageal varices haemorrhage 29.68 15.09 36 77318 2666 29494507
Hepatectomy 29.51 15.09 10 77344 65 29497108
Recall phenomenon 29.38 15.09 18 77336 517 29496656
Hypertensive crisis 29.32 15.09 64 77290 7784 29489389
Cerebrovascular accident 29.28 15.09 103 77251 76808 29420365
Lymphangiosis carcinomatosa 29.24 15.09 21 77333 791 29496382
Perforation bile duct 29.08 15.09 8 77346 22 29497151
Blood alkaline phosphatase abnormal 28.99 15.09 16 77338 376 29496797
Failure to anastomose 28.39 15.09 13 77341 202 29496971
Acute respiratory distress syndrome 28.27 15.09 127 77227 22808 29474365
Encapsulating peritoneal sclerosis 28.02 15.09 18 77336 563 29496610
Hypovolaemic shock 27.98 15.09 54 77300 6018 29491155
Accidental overdose 27.80 15.09 6 77348 17587 29479586
Haemoglobinuria 27.79 15.09 18 77336 571 29496602
Device related infection 27.69 15.09 97 77257 15539 29481634
Hyperbilirubinaemia 27.63 15.09 94 77260 14840 29482333
Haemorrhage intracranial 27.42 15.09 3 77351 14539 29482634
Sedation 27.38 15.09 6 77348 17399 29479774
Anal sphincter atony 27.30 15.09 10 77344 84 29497089
Necrotising oesophagitis 27.24 15.09 17 77337 505 29496668
Subdural haematoma 27.18 15.09 7 77347 18186 29478987
Delirium 27.17 15.09 38 77316 39359 29457814
Gastric perforation 27.13 15.09 31 77323 2155 29495018
Brain teratoma 26.99 15.09 7 77347 14 29497159
Pulmonary toxicity 26.97 15.09 47 77307 4843 29492330
Portal vein thrombosis 26.88 15.09 38 77316 3271 29493902
Ocular toxicity 26.77 15.09 12 77342 177 29496996
ECG signs of myocardial ischaemia 26.53 15.09 12 77342 181 29496992
Muscular weakness 26.47 15.09 79 77275 61973 29435200
Head injury 26.42 15.09 5 77349 16076 29481097
Anaphylactic reaction 26.36 15.09 142 77212 27431 29469742
Cachexia 26.29 15.09 54 77300 6295 29490878
Pseudocirrhosis 26.06 15.09 7 77347 17 29497156
Emotional distress 25.87 15.09 3 77351 13892 29483281
Pruritus 25.72 15.09 439 76915 116410 29380763
Localised infection 25.68 15.09 3 77351 13813 29483360
Oesophagitis 25.63 15.09 79 77275 11844 29485329
Vocal cord paralysis 25.59 15.09 20 77334 858 29496315
Hyperkalaemia 25.58 15.09 79 77275 61313 29435860
Osteomyelitis 25.42 15.09 3 77351 13706 29483467
Blood cholesterol increased 25.30 15.09 5 77349 15590 29481583
Medication error 25.12 15.09 12 77342 21199 29475974
Nasal congestion 25.07 15.09 9 77345 18870 29478303
Wound dehiscence 25.03 15.09 35 77319 2982 29494191
Ileal perforation 24.70 15.09 18 77336 694 29496479
Pulmonary artery thrombosis 24.69 15.09 17 77337 598 29496575
Throat irritation 24.55 15.09 64 77290 8721 29488452
Dyspnoea 24.52 15.09 1066 76288 325666 29171507
Swelling 24.36 15.09 34 77320 35249 29461924
Basal cell carcinoma 24.33 15.09 7 77347 16903 29480270
Nephrotic syndrome 24.09 15.09 52 77302 6276 29490897
Papilloedema 24.02 15.09 30 77324 2290 29494883
Full blood count abnormal 23.97 15.09 5 77349 15008 29482165
Koebner phenomenon 23.87 15.09 8 77346 50 29497123
Blood creatinine increased 23.83 15.09 128 77226 84974 29412199
Perihepatic abscess 23.65 15.09 9 77345 85 29497088
Adverse drug reaction 23.62 15.09 17 77337 24003 29473170
Cardiac ventricular disorder 23.62 15.09 12 77342 237 29496936
Upper respiratory tract infection 23.61 15.09 22 77332 27327 29469846
Renal disorder 23.54 15.09 15 77339 22580 29474593
Fistula of small intestine 23.53 15.09 14 77340 381 29496792
Pachymeningitis 23.37 15.09 9 77345 88 29497085
Road traffic accident 23.22 15.09 6 77348 15555 29481618
Erectile dysfunction 23.22 15.09 9 77345 18000 29479173
Anaphylactoid reaction 23.16 15.09 27 77327 1918 29495255
Product prescribing error 23.15 15.09 9 77345 17967 29479206
Biliary tract infection 23.13 15.09 15 77339 477 29496696
Gait disturbance 23.01 15.09 106 77248 73243 29423930
Rectal cancer metastatic 22.92 15.09 11 77343 191 29496982
Productive cough 22.72 15.09 29 77325 31230 29465943
COVID-19 22.64 15.09 37 77317 35977 29461196
Hyperpyrexia 22.53 15.09 29 77325 2281 29494892
Blood pressure systolic increased 22.42 15.09 8 77346 16837 29480336
Pelvic fluid collection 22.36 15.09 9 77345 100 29497073
Nephrolithiasis 22.32 15.09 20 77334 25314 29471859
Muscle contractions involuntary 22.30 15.09 25 77329 1702 29495471
Intestinal dilatation 22.29 15.09 20 77334 1040 29496133
Oesophagobronchial fistula 22.28 15.09 10 77344 148 29497025
Hepatic failure 22.27 15.09 150 77204 31362 29465811
Cerebral vasoconstriction 22.22 15.09 11 77343 205 29496968
Interventricular septum rupture 22.22 15.09 6 77348 15 29497158
Embolism 22.17 15.09 53 77301 6843 29490330
Skin fissures 22.05 15.09 38 77316 3881 29493292
Metastases to muscle 21.99 15.09 11 77343 210 29496963
Toxic epidermal necrolysis 21.91 15.09 10 77344 18143 29479030
Fingerprint loss 21.87 15.09 7 77347 37 29497136
Cholestasis 21.86 15.09 120 77234 23342 29473831
Laryngeal oedema 21.85 15.09 33 77321 3015 29494158
Metastases to retroperitoneum 21.71 15.09 11 77343 216 29496957
Jaundice 21.64 15.09 141 77213 29155 29468018
Pulmonary oedema 21.58 15.09 50 77304 42685 29454488
Obstruction gastric 21.50 15.09 18 77336 852 29496321
Oropharyngeal pain 21.46 15.09 27 77327 29258 29467915
Induration 21.40 15.09 18 77336 858 29496315
Eosinophilia 21.38 15.09 16 77338 22145 29475028
Gastric dilatation 21.29 15.09 15 77339 548 29496625
Hyperfibrinolysis 21.18 15.09 6 77348 19 29497154
Drug intolerance 21.06 15.09 61 77293 48318 29448855
Underdose 21.04 15.09 3 77351 11866 29485307
Chronic myeloid leukaemia 20.99 15.09 26 77328 1968 29495205
Shock 20.98 15.09 111 77243 21293 29475880
Sarcoidosis 20.98 15.09 30 77324 2610 29494563
Liver abscess 20.96 15.09 34 77320 3304 29493869
Aortic thrombosis 20.91 15.09 16 77338 665 29496508
Monocytopenia 20.89 15.09 8 77346 77 29497096
Folliculitis 20.88 15.09 37 77317 3863 29493310
Portal vein dilatation 20.82 15.09 5 77349 6 29497167
Hypersplenism 20.65 15.09 12 77342 312 29496861
Full blood count decreased 20.60 15.09 8 77346 15984 29481189
Laboratory test abnormal 20.47 15.09 11 77343 18174 29478999
Trismus 20.39 15.09 28 77326 2345 29494828
Cold sweat 20.34 15.09 60 77294 8782 29488391
Catheter site extravasation 20.27 15.09 8 77346 84 29497089
Acral peeling skin syndrome 20.22 15.09 7 77347 49 29497124
Allodynia 20.14 15.09 15 77339 598 29496575
Mucosal toxicity 20.08 15.09 10 77344 189 29496984
Small intestinal perforation 20.01 15.09 23 77331 1609 29495564
Hypercreatinaemia 19.94 15.09 9 77345 135 29497038
Band sensation 19.86 15.09 8 77346 89 29497084
Feeling cold 19.85 15.09 61 77293 9130 29488043
Respiratory arrest 19.80 15.09 23 77331 25810 29471363
Pneumonitis chemical 19.70 15.09 9 77345 139 29497034
Injection site erythema 19.68 15.09 6 77348 13950 29483223
Hand-foot-genital syndrome 19.62 15.09 5 77349 9 29497164
Hot flush 19.59 15.09 84 77270 14786 29482387
Pneumonitis 19.52 15.09 133 77221 27911 29469262
Labelled drug-drug interaction medication error 19.52 15.09 4 77350 12155 29485018
Peripheral ischaemia 19.41 15.09 42 77312 5077 29492096
Gout 19.37 15.09 10 77344 16901 29480272
Cataract 19.32 15.09 18 77336 22360 29474813
Fistula 19.30 15.09 42 77312 5097 29492076
Ischiorectal hernia 19.28 15.09 5 77349 10 29497163
Rectosigmoid cancer 19.20 15.09 9 77345 148 29497025
Peritoneal haematoma 19.09 15.09 7 77347 59 29497114
Choking sensation 18.97 15.09 18 77336 1006 29496167
Oropharyngeal spasm 18.93 15.09 9 77345 153 29497020
Metastases to spleen 18.89 15.09 12 77342 368 29496805
Perineal disorder 18.89 15.09 7 77347 61 29497112
Neck pain 18.81 15.09 17 77337 21430 29475743
Gastrointestinal stoma complication 18.73 15.09 19 77335 1153 29496020
Malaise 18.68 15.09 548 76806 159054 29338119
Metastases to bone marrow 18.59 15.09 13 77341 469 29496704
Sleep disorder 18.38 15.09 22 77332 24364 29472809
Appendicitis noninfective 18.37 15.09 5 77349 13 29497160
Fixed eruption 18.33 15.09 19 77335 1183 29495990
Haemoglobin abnormal 18.24 15.09 31 77323 3130 29494043
Conjunctivitis 18.14 15.09 54 77300 7944 29489229
Nephritis allergic 18.08 15.09 12 77342 397 29496776
Chemical peritonitis 18.03 15.09 8 77346 115 29497058
B-cell small lymphocytic lymphoma 17.91 15.09 8 77346 117 29497056
Microangiopathic haemolytic anaemia 17.72 15.09 16 77338 839 29496334
Balance disorder 17.72 15.09 43 77311 36127 29461046
Amaurosis fugax 17.55 15.09 13 77341 514 29496659
Wheezing 17.51 15.09 38 77316 33202 29463971
Proteus infection 17.40 15.09 16 77338 859 29496314
Vascular injury 17.39 15.09 10 77344 255 29496918
Perineal ulceration 17.38 15.09 5 77349 17 29497156
Oedema peripheral 17.36 15.09 180 77174 103377 29393796
Acute motor-sensory axonal neuropathy 17.32 15.09 8 77346 127 29497046
Oral dysaesthesia 17.29 15.09 7 77347 79 29497094
Peritoneal disorder 17.28 15.09 10 77344 258 29496915
Haematemesis 17.27 15.09 117 77237 24509 29472664
Blood triglycerides increased 17.24 15.09 6 77348 12828 29484345
Pulmonary hypertension 17.23 15.09 14 77340 18594 29478579
Duodenal stenosis 17.22 15.09 9 77345 189 29496984
Angioedema 17.21 15.09 36 77318 31879 29465294
Tunnel vision 17.16 15.09 12 77342 433 29496740
Metastases to pelvis 17.04 15.09 10 77344 265 29496908
Intrahepatic portal hepatic venous fistula 17.03 15.09 4 77350 4 29497169
Blindness transient 17.02 15.09 23 77331 1897 29495276
Abdominal sepsis 16.99 15.09 16 77338 886 29496287
Obstructive airways disorder 16.92 15.09 4 77350 11012 29486161
Lower respiratory tract infection 16.87 15.09 27 77327 26475 29470698
VIth nerve disorder 16.75 15.09 5 77349 20 29497153
Diffuse large B-cell lymphoma refractory 16.69 15.09 16 77338 906 29496267
Thrombotic thrombocytopenic purpura 16.63 15.09 30 77324 3176 29493997
Phrenic nerve paralysis 16.48 15.09 7 77347 90 29497083
Bacterial colitis 16.42 15.09 6 77348 50 29497123
Nail disorder 16.40 15.09 22 77332 1802 29495371
Peripheral motor neuropathy 16.39 15.09 21 77333 1644 29495529
Hypersomnia 16.33 15.09 4 77350 10750 29486423
Hypotension 16.32 15.09 642 76712 193712 29303461
Infusion site urticaria 16.27 15.09 7 77347 93 29497080
Prostate cancer 16.26 15.09 26 77328 25501 29471672
Pancreatitis 16.15 15.09 42 77312 34472 29462701
Xerosis 16.12 15.09 12 77342 478 29496695
Abdominal mass 16.09 15.09 18 77336 1222 29495951
Blood pressure increased 16.02 15.09 120 77234 73683 29423490
Ichthyosis 16.01 15.09 7 77347 97 29497076
Prostatic calcification 16.01 15.09 7 77347 97 29497076
Colon cancer recurrent 15.94 15.09 7 77347 98 29497075
Electromyogram abnormal 15.92 15.09 6 77348 55 29497118
Retroperitoneal abscess 15.88 15.09 8 77346 155 29497018
Radiation interaction 15.85 15.09 5 77349 25 29497148
Stevens-Johnson syndrome 15.80 15.09 12 77342 16485 29480688
Rectal obstruction 15.77 15.09 4 77350 7 29497166
Pneumoperitoneum 15.74 15.09 20 77334 1553 29495620
Trichomegaly 15.69 15.09 5 77349 26 29497147
Gastrointestinal mucosal necrosis 15.65 15.09 8 77346 160 29497013
Blood glucose decreased 15.61 15.09 6 77348 12063 29485110
Product administration error 15.61 15.09 9 77345 14301 29482872
Bradycardia 15.57 15.09 104 77250 65525 29431648
Neurosarcoidosis 15.56 15.09 8 77346 162 29497011
Therapeutic product effect prolonged 15.56 15.09 9 77345 232 29496941
Respiratory depression 15.48 15.09 8 77346 13515 29483658
Vestibular neuronitis 15.39 15.09 8 77346 166 29497007
Proctitis 15.28 15.09 23 77331 2096 29495077
Limb injury 15.18 15.09 3 77351 9352 29487821
Skin laceration 15.16 15.09 5 77349 11057 29486116
Soft tissue swelling 15.14 15.09 10 77344 328 29496845
Faeces discoloured 15.14 15.09 8 77346 13343 29483830
Hypophagia 15.13 15.09 100 77254 20772 29476401
Type III immune complex mediated reaction 15.12 15.09 9 77345 245 29496928
Hyperlipidaemia 15.10 15.09 7 77347 12583 29484590

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuropathy peripheral 2383.96 15.31 1865 116609 115660 64264598
Neutropenia 1406.86 15.31 1953 116521 237671 64142587
Neurotoxicity 1250.47 15.31 721 117753 26683 64353575
Disease progression 1214.65 15.31 1396 117078 140284 64239974
Thrombocytopenia 1049.48 15.31 1642 116832 222159 64158099
Diarrhoea 976.97 15.31 3221 115253 719483 63660775
Palmar-plantar erythrodysaesthesia syndrome 881.84 15.31 588 117886 28231 64352027
Laryngospasm 848.92 15.31 296 118178 3149 64377109
Dermatitis acneiform 794.41 15.31 362 118112 8081 64372177
Paraesthesia 662.99 15.31 1011 117463 133511 64246747
Skin toxicity 655.78 15.31 294 118180 6308 64373950
Arteriospasm coronary 625.87 15.31 269 118205 5196 64375062
Mucosal inflammation 573.23 15.31 639 117835 61945 64318313
Peripheral sensory neuropathy 520.45 15.31 300 118174 11078 64369180
Bone marrow failure 508.26 15.31 529 117945 47423 64332835
Vomiting 500.32 15.31 2167 116307 548950 63831308
Myelosuppression 466.13 15.31 371 118103 23459 64356799
Venoocclusive liver disease 457.90 15.31 264 118210 9751 64370507
Arthralgia 453.54 15.31 126 118348 442134 63938124
Erythema 423.37 15.31 1009 117465 186061 64194197
Polyneuropathy 422.14 15.31 325 118149 19569 64360689
Metastases to liver 414.16 15.31 347 118127 23594 64356664
Bronchospasm 407.99 15.31 330 118144 21352 64358906
Drug ineffective 394.79 15.31 585 117889 839662 63540596
Paronychia 387.34 15.31 204 118270 6288 64373970
Interstitial lung disease 357.81 15.31 643 117831 97089 64283169
Headache 357.35 15.31 271 118203 529196 63851062
Portal hypertension 352.91 15.31 189 118285 6030 64374228
Nausea 346.95 15.31 2545 115929 783255 63597003
Chills 339.57 15.31 767 117707 136497 64243761
Gastrointestinal perforation 325.19 15.31 171 118303 5253 64375005
Enteritis 311.69 15.31 222 118252 11855 64368403
Gastrointestinal toxicity 308.35 15.31 164 118310 5158 64375100
Haematotoxicity 303.11 15.31 224 118250 12672 64367586
Product dose omission issue 298.85 15.31 14 118460 194733 64185525
Dysaesthesia pharynx 290.61 15.31 69 118405 137 64380121
Joint swelling 286.24 15.31 31 118443 215351 64164907
Fall 280.14 15.31 214 118260 416612 63963646
Throat tightness 260.67 15.31 264 118210 22896 64357362
Neutrophil count decreased 248.81 15.31 481 117993 76715 64303543
Stridor 248.49 15.31 138 118336 4736 64375522
Neoplasm progression 243.81 15.31 337 118137 40627 64339631
Metastases to lung 235.00 15.31 207 118267 15057 64365201
Cardiotoxicity 231.50 15.31 174 118300 10100 64370158
Stomatitis 226.15 15.31 571 117903 109034 64271224
Type I hypersensitivity 223.75 15.31 116 118358 3458 64376800
Pain 223.38 15.31 424 118050 553087 63827171
Drug abuse 222.96 15.31 4 118470 132370 64247888
Leukopenia 217.88 15.31 536 117938 100706 64279552
Malignant neoplasm progression 213.34 15.31 569 117905 112302 64267956
Focal nodular hyperplasia 207.37 15.31 68 118406 589 64379669
Dysarthria 204.82 15.31 381 118093 59025 64321233
Arthropathy 202.33 15.31 4 118470 120963 64259295
Weight increased 201.75 15.31 70 118404 213278 64166980
Hyperammonaemia 199.65 15.31 157 118317 9747 64370511
Peripheral swelling 198.86 15.31 68 118406 209085 64171173
Decreased appetite 197.00 15.31 1028 117446 280261 64099997
Hyperammonaemic encephalopathy 196.29 15.31 111 118363 3947 64376311
Flushing 194.88 15.31 440 118034 78208 64302050
Non-cirrhotic portal hypertension 192.48 15.31 57 118417 338 64379920
Drug interaction 188.49 15.31 233 118241 361850 64018408
Depression 182.36 15.31 55 118419 183236 64197022
Sinusitis 181.64 15.31 26 118448 145902 64234356
Abdominal pain 181.13 15.31 1085 117389 311290 64068968
Ascites 178.96 15.31 369 118105 61632 64318626
Febrile neutropenia 178.45 15.31 750 117724 186907 64193351
Nasopharyngitis 172.60 15.31 72 118402 196001 64184257
Anaphylactic shock 172.26 15.31 244 118230 30084 64350174
Insomnia 170.40 15.31 75 118399 197761 64182497
Splenomegaly 168.78 15.31 186 118288 17775 64362483
Therapy partial responder 167.88 15.31 144 118330 10104 64370154
Swelling 165.05 15.31 45 118429 160173 64220085
Dysphonia 161.78 15.31 299 118175 46083 64334175
Overdose 158.51 15.31 48 118426 159518 64220740
Contraindicated product administered 158.35 15.31 10 118464 107819 64272439
Proteinuria 157.39 15.31 223 118251 27500 64352758
Nodular regenerative hyperplasia 155.53 15.31 59 118415 811 64379447
Intestinal obstruction 155.30 15.31 256 118218 36030 64344228
Feeling hot 152.57 15.31 289 118185 45374 64334884
Hypersensitivity 152.20 15.31 739 117735 195713 64184545
Product use issue 151.86 15.31 45 118429 151670 64228588
Hypomagnesaemia 149.72 15.31 256 118218 37120 64343138
Pyrexia 145.07 15.31 1615 116859 557029 63823229
Contusion 142.52 15.31 20 118454 113945 64266313
Therapeutic product effect decreased 142.49 15.31 21 118453 115330 64264928
Pain in extremity 138.62 15.31 214 118260 302871 64077387
Maternal exposure during pregnancy 137.55 15.31 10 118464 95874 64284384
Influenza 137.28 15.31 17 118457 106514 64273744
Injection site pain 135.97 15.31 21 118453 111387 64268871
Paraesthesia oral 133.92 15.31 142 118332 12989 64367269
Pneumonia 133.65 15.31 552 117922 559024 63821234
Hyperhidrosis 133.59 15.31 518 117956 124402 64255856
Cytokine release syndrome 132.46 15.31 177 118297 20652 64359606
Abdominal discomfort 132.24 15.31 86 118388 182236 64198022
Cardiac failure congestive 132.01 15.31 38 118436 130542 64249716
Dyspnoea 129.78 15.31 1943 116531 716731 63663527
Carcinoembryonic antigen increased 129.48 15.31 65 118409 1808 64378450
Dysaesthesia 129.29 15.31 92 118382 4903 64375355
Asthma 128.23 15.31 13 118461 95212 64285046
Systemic lupus erythematosus 128.06 15.31 3 118471 77609 64302649
Varices oesophageal 124.81 15.31 91 118383 5039 64375219
Oxygen saturation decreased 124.18 15.31 456 118018 106720 64273538
Large intestine perforation 122.73 15.31 133 118341 12471 64367787
Tumour perforation 122.53 15.31 39 118435 304 64379954
Anastomotic leak 122.06 15.31 51 118423 915 64379343
Somnolence 121.36 15.31 117 118357 203528 64176730
Dehydration 120.44 15.31 745 117729 216018 64164240
Anxiety 120.10 15.31 117 118357 202532 64177726
Bronchitis 118.84 15.31 27 118447 108716 64271542
Intentional product misuse 118.50 15.31 3 118471 72292 64307966
Enterocolitis 117.34 15.31 127 118347 11891 64368367
Suicide attempt 116.18 15.31 3 118471 71004 64309254
Laryngeal discomfort 115.75 15.31 41 118433 458 64379800
Arthritis 114.01 15.31 11 118463 83803 64296455
Immune thrombocytopenia 113.07 15.31 139 118335 14927 64365331
Skin reaction 112.75 15.31 126 118348 12226 64368032
Colorectal cancer metastatic 112.36 15.31 48 118426 912 64379346
Asthenia 112.06 15.31 1240 117234 426804 63953454
Intravascular haemolysis 111.54 15.31 44 118430 676 64379582
Metastases to peritoneum 107.52 15.31 72 118402 3475 64376783
Hospitalisation 107.42 15.31 8 118466 75199 64305059
Myalgia 106.85 15.31 81 118393 158536 64221722
Laryngeal oedema 106.57 15.31 95 118379 7018 64373240
Posterior reversible encephalopathy syndrome 105.14 15.31 167 118307 22779 64357479
Hypertransaminasaemia 103.70 15.31 94 118380 7097 64373161
Ileus 103.66 15.31 166 118308 22800 64357458
Osteoarthritis 102.42 15.31 3 118471 63333 64316925
Peritonitis 101.01 15.31 172 118302 24851 64355407
Musculoskeletal stiffness 99.45 15.31 51 118423 123155 64257103
Administration site extravasation 98.31 15.31 45 118429 1014 64379244
Extravasation 97.47 15.31 65 118409 3115 64377143
Condition aggravated 96.02 15.31 356 118118 372070 64008188
Disseminated intravascular coagulation 95.05 15.31 194 118280 32154 64348104
Injection site erythema 94.46 15.31 10 118464 70790 64309468
Pemphigus 94.24 15.31 4 118470 60697 64319561
Hyperthermia 94.10 15.31 129 118345 15421 64364837
Stress 93.94 15.31 4 118470 60530 64319728
Drug intolerance 93.50 15.31 125 118349 187867 64192391
Lower respiratory tract infection 92.95 15.31 29 118445 94585 64285673
Intestinal perforation 92.61 15.31 127 118347 15186 64365072
Portal shunt 89.75 15.31 22 118452 53 64380205
Haemolytic anaemia 89.44 15.31 128 118346 15925 64364333
General physical health deterioration 87.51 15.31 659 117815 203766 64176492
Exposure during pregnancy 87.48 15.31 18 118456 77657 64302601
Suicidal ideation 87.25 15.31 10 118464 66532 64313726
Confusional state 86.92 15.31 222 118252 260922 64119336
Pneumatosis intestinalis 86.72 15.31 74 118400 5155 64375103
Glossodynia 86.66 15.31 9 118465 64687 64315571
Wound 85.56 15.31 18 118456 76459 64303799
Hypertensive crisis 85.25 15.31 134 118340 18114 64362144
Cholinergic syndrome 85.17 15.31 38 118436 805 64379453
Rhabdomyolysis 85.09 15.31 31 118443 91695 64288563
Tumour necrosis 83.34 15.31 47 118427 1662 64378596
Dihydropyrimidine dehydrogenase deficiency 82.30 15.31 23 118451 107 64380151
Diffuse large B-cell lymphoma recurrent 81.55 15.31 58 118416 3088 64377170
Memory impairment 81.11 15.31 28 118446 85654 64294604
Tongue oedema 79.97 15.31 75 118399 5915 64374343
Anastomotic complication 78.26 15.31 29 118445 372 64379886
Fluid retention 78.04 15.31 9 118465 59597 64320661
Drug hypersensitivity 77.73 15.31 204 118270 237611 64142647
Incorrect dose administered 77.54 15.31 10 118464 60755 64319503
Electrocardiogram QT prolonged 76.89 15.31 25 118449 79423 64300835
Infusion related reaction 76.56 15.31 541 117933 163926 64216332
Inappropriate schedule of product administration 76.27 15.31 37 118437 92249 64288009
Acute coronary syndrome 75.66 15.31 131 118343 19179 64361079
Blood cholesterol increased 75.46 15.31 4 118470 50062 64330196
Off label use 74.13 15.31 1599 116875 631207 63749051
Anastomotic fistula 73.60 15.31 20 118454 82 64380176
Toxic leukoencephalopathy 72.95 15.31 35 118439 880 64379378
Aggression 71.92 15.31 3 118471 46229 64334029
Pulmonary embolism 71.40 15.31 487 117987 145869 64234389
Chronic obstructive pulmonary disease 71.19 15.31 21 118453 71027 64309231
Nicotinic acid deficiency 71.13 15.31 21 118453 123 64380135
Hepatic enzyme increased 70.25 15.31 81 118393 129862 64250396
Stomal varices 70.24 15.31 17 118457 38 64380220
Rectal perforation 69.63 15.31 32 118442 728 64379530
Electrocardiogram ST segment elevation 69.62 15.31 76 118398 7183 64373075
Stress cardiomyopathy 68.81 15.31 85 118389 9172 64371086
Leukoencephalopathy 68.67 15.31 74 118400 6893 64373365
Tumour lysis syndrome 68.62 15.31 126 118348 19314 64360944
Mobility decreased 68.57 15.31 36 118438 85804 64294454
Myocardial infarction 68.39 15.31 125 118349 165696 64214562
Hypokalaemia 67.62 15.31 419 118055 121484 64258774
Vascular pain 67.08 15.31 32 118442 794 64379464
Hypertension 66.73 15.31 749 117725 258512 64121746
Injection site reaction 66.53 15.31 5 118469 46659 64333599
Anaphylactic reaction 66.36 15.31 276 118198 68388 64311870
Neuromyotonia 66.01 15.31 18 118456 75 64380183
Platelet count decreased 65.30 15.31 529 117945 167182 64213076
Upper respiratory tract infection 65.17 15.31 26 118448 72759 64307499
Osteoporosis 64.57 15.31 3 118471 42077 64338181
Cholangitis 64.44 15.31 89 118385 10713 64369545
Coronary artery disease 64.05 15.31 16 118458 60417 64319841
Hiccups 64.02 15.31 78 118396 8298 64371960
Evans syndrome 63.38 15.31 25 118449 384 64379874
Feeling abnormal 63.24 15.31 92 118382 133510 64246748
Hypoalbuminaemia 62.94 15.31 115 118359 17559 64362699
Blood pressure fluctuation 62.77 15.31 10 118464 51861 64328397
Subileus 62.04 15.31 60 118414 4917 64375341
Migraine 61.94 15.31 19 118455 62658 64317600
Blood glucose increased 61.15 15.31 54 118420 98019 64282239
Band sensation 60.76 15.31 28 118446 641 64379617
Colon cancer metastatic 60.62 15.31 40 118434 1883 64378375
Hallucination 60.43 15.31 29 118445 72759 64307499
Drug reaction with eosinophilia and systemic symptoms 60.15 15.31 13 118461 54204 64326054
Metastases to lymph nodes 59.96 15.31 77 118397 8640 64371618
Rash pustular 59.80 15.31 82 118392 9803 64370455
Gastrointestinal anastomotic leak 59.72 15.31 24 118450 388 64379870
Dizziness 59.42 15.31 505 117969 429658 63950600
Gait disturbance 59.07 15.31 144 118330 172011 64208247
Periportal sinus dilatation 58.57 15.31 14 118460 29 64380229
Herpes zoster 57.85 15.31 37 118437 79150 64301108
Sedation 57.56 15.31 5 118469 41457 64338801
Chemical peritonitis 57.12 15.31 21 118453 263 64379995
Injection site pruritus 57.07 15.31 3 118471 37823 64342435
Stoma site haemorrhage 56.87 15.31 36 118438 1577 64378681
Choking sensation 56.53 15.31 49 118425 3486 64376772
Speech disorder 55.97 15.31 206 118268 48235 64332023
Mucosal toxicity 55.61 15.31 24 118450 468 64379790
Cellulitis 55.52 15.31 54 118420 93603 64286655
Oesophageal varices haemorrhage 55.42 15.31 49 118425 3580 64376678
Influenza like illness 55.31 15.31 22 118452 61680 64318578
International normalised ratio increased 55.14 15.31 39 118435 79128 64301130
Hyperbilirubinaemia 55.13 15.31 121 118353 21084 64359174
Large intestinal obstruction 54.81 15.31 43 118431 2659 64377599
Emotional distress 53.93 15.31 3 118471 36035 64344223
Cyanosis 53.77 15.31 123 118351 22032 64358226
Treatment failure 53.77 15.31 82 118392 116734 64263524
Anaemia 53.62 15.31 985 117489 377695 64002563
Treatment noncompliance 53.48 15.31 8 118466 43474 64336784
Palmar erythema 52.52 15.31 35 118439 1675 64378583
Ocular toxicity 52.38 15.31 25 118449 621 64379637
Hepatic atrophy 52.38 15.31 22 118452 400 64379858
Diffuse large B-cell lymphoma refractory 52.36 15.31 30 118444 1094 64379164
ECG signs of myocardial ischaemia 52.34 15.31 21 118453 338 64379920
Encapsulating peritoneal sclerosis 52.28 15.31 27 118447 798 64379460
Wrong technique in product usage process 52.26 15.31 27 118447 64947 64315311
Metastasis 51.81 15.31 58 118416 5637 64374621
Prinzmetal angina 51.64 15.31 33 118441 1470 64378788
Necrotising fasciitis 51.50 15.31 56 118418 5270 64374988
Drug level increased 50.70 15.31 3 118471 34193 64346065
Hepatic failure 50.68 15.31 219 118255 55175 64325083
Enterocutaneous fistula 50.57 15.31 33 118441 1524 64378734
Helicobacter infection 49.70 15.31 6 118468 38356 64341902
Cough 49.58 15.31 338 118136 301810 64078448
Hypervolaemia 49.57 15.31 6 118468 38279 64341979
Urinary tract infection 49.33 15.31 238 118236 231358 64148900
Nasal congestion 49.17 15.31 24 118450 59634 64320624
Drug dependence 49.16 15.31 3 118471 33309 64346949
Enterovesical fistula 48.78 15.31 27 118447 920 64379338
Gastric perforation 48.75 15.31 45 118429 3478 64376780
Psychotic disorder 48.47 15.31 4 118470 34574 64345684
Dysphagia 48.30 15.31 349 118125 106463 64273795
Blister 47.63 15.31 47 118427 80920 64299338
Ileal perforation 47.41 15.31 26 118448 870 64379388
Pericarditis 47.35 15.31 28 118446 62488 64317770
Pulmonary toxicity 47.31 15.31 68 118406 8493 64371765
Acute abdomen 46.90 15.31 40 118434 2784 64377474
Transdifferentiation of neoplasm 46.31 15.31 14 118460 90 64380168
Septic shock 46.24 15.31 342 118132 105095 64275163
Diabetes mellitus 45.96 15.31 33 118441 66441 64313817
Liver function test abnormal 45.85 15.31 26 118448 59375 64320883
Metastases to bone marrow 45.64 15.31 23 118451 645 64379613
Metastases to spleen 45.40 15.31 21 118453 485 64379773
Sleep disorder 44.86 15.31 27 118447 59682 64320576
Productive cough 44.80 15.31 41 118433 73162 64307096
Formication 44.21 15.31 47 118427 4310 64375948
Steatohepatitis 44.20 15.31 24 118450 787 64379471
Malignant ascites 43.84 15.31 26 118448 1012 64379246
Viral infection 43.65 15.31 7 118467 36133 64344125
Hypoglycaemia 43.42 15.31 61 118413 89831 64290427
Biliary tract infection 43.28 15.31 25 118449 926 64379332
Head injury 42.89 15.31 5 118469 32837 64347421
Performance status decreased 42.71 15.31 51 118423 5313 64374945
Oxygen saturation normal 42.41 15.31 8 118466 0 64380258
White blood cell count decreased 41.93 15.31 459 118015 157378 64222880
Cataract 41.67 15.31 21 118453 51241 64329017
Hyperpyrexia 41.63 15.31 49 118425 5028 64375230
Colitis 41.30 15.31 215 118259 58459 64321799
Haemoglobinuria 40.81 15.31 22 118452 711 64379547
Splenorenal shunt 40.55 15.31 9 118465 11 64380247
Skin fissures 40.48 15.31 70 118404 10236 64370022
Hyperkalaemia 40.12 15.31 78 118396 101051 64279207
Nervousness 39.87 15.31 4 118470 29552 64350706
Cold sweat 39.54 15.31 91 118383 16364 64363894
Unevaluable event 39.11 15.31 22 118452 50467 64329791
Tachycardia 38.82 15.31 433 118041 149146 64231112
Type II hypersensitivity 38.49 15.31 10 118464 33 64380225
Medication error 38.38 15.31 22 118452 49944 64330314
Trismus 38.04 15.31 46 118428 4855 64375403
Lip oedema 37.53 15.31 47 118427 5142 64375116
Oropharyngeal pain 37.51 15.31 66 118408 88801 64291457
Acute respiratory distress syndrome 37.21 15.31 156 118318 38779 64341479
Basal cell carcinoma 37.19 15.31 6 118468 30832 64349426
Cardiac disorder 36.93 15.31 29 118445 55787 64324471
Cold dysaesthesia 36.88 15.31 8 118466 8 64380250
Recall phenomenon 36.84 15.31 23 118451 983 64379275
K-ras gene mutation 36.80 15.31 10 118464 41 64380217
Irritability 36.55 15.31 11 118463 36735 64343523
Underdose 36.17 15.31 3 118471 25826 64354432
Portal vein dilatation 36.05 15.31 10 118464 45 64380213
Discomfort 36.04 15.31 58 118416 80820 64299438
Portal venous gas 35.99 15.31 16 118458 336 64379922
Heart rate decreased 35.94 15.31 29 118445 55038 64325220
Factor VII deficiency 35.80 15.31 9 118465 25 64380233
Small intestinal perforation 35.79 15.31 33 118441 2547 64377711
Peripheral motor neuropathy 35.52 15.31 35 118439 2935 64377323
Abnormal behaviour 35.44 15.31 9 118465 33613 64346645
Duodenal ulcer perforation 35.11 15.31 10 118464 34615 64345643
Infusion related hypersensitivity reaction 35.06 15.31 13 118461 167 64380091
Hepatocellular injury 34.82 15.31 170 118304 45065 64335193
Neck pain 34.73 15.31 37 118437 61496 64318762
Splenic artery thrombosis 34.71 15.31 10 118464 53 64380205
Haematoma 34.62 15.31 21 118453 46229 64334029
Hallucination, visual 34.51 15.31 5 118469 27829 64352429
Product prescribing error 34.29 15.31 11 118463 35258 64345000
Guillain-Barre syndrome 34.19 15.31 55 118419 7580 64372678
Hypertrichosis 34.07 15.31 23 118451 1125 64379133
Perforation 34.07 15.31 23 118451 1125 64379133
Balance disorder 33.93 15.31 64 118410 83862 64296396
COVID-19 33.71 15.31 42 118432 65098 64315160
Blood pressure immeasurable 33.69 15.31 28 118446 1880 64378378
Laryngeal dyspnoea 33.62 15.31 14 118460 249 64380009
Pharyngeal paraesthesia 33.58 15.31 28 118446 1889 64378369
Metastases to meninges 33.34 15.31 33 118441 2782 64377476
Small intestinal obstruction 33.12 15.31 107 118367 23466 64356792
Hypovolaemic shock 33.07 15.31 64 118410 10202 64370056
Short-bowel syndrome 33.00 15.31 16 118458 412 64379846
Road traffic accident 32.85 15.31 8 118466 30737 64349521
Rhinorrhoea 32.81 15.31 37 118437 59932 64320326
Aortic thrombosis 32.69 15.31 25 118449 1489 64378769
Abortion spontaneous 32.41 15.31 4 118470 25139 64355119
Blood pressure systolic increased 32.33 15.31 26 118448 49427 64330831
Dysgeusia 32.15 15.31 171 118303 46876 64333382
Embolism 32.01 15.31 70 118404 12165 64368093
Cystitis radiation 31.97 15.31 11 118463 112 64380146
Right ventricular ejection fraction decreased 31.84 15.31 9 118465 44 64380214
Noninfective epididymitis 31.81 15.31 6 118468 0 64380258
Accidental overdose 31.69 15.31 11 118463 33546 64346712
Oesophageal haemorrhage 31.68 15.31 25 118449 1559 64378699
Hydronephrosis 31.64 15.31 76 118398 14049 64366209
Jaundice 31.58 15.31 174 118300 48338 64331920
Trichomegaly 31.52 15.31 10 118464 77 64380181
Biliary fistula 31.52 15.31 10 118464 77 64380181
Toxicity to various agents 31.46 15.31 474 118000 363039 64017219
Muscle contractions involuntary 31.41 15.31 34 118440 3183 64377075
Intestinal ischaemia 31.28 15.31 67 118407 11482 64368776
Neutropenic sepsis 31.23 15.31 104 118370 23168 64357090
Pulmonary fibrosis 31.16 15.31 123 118351 29755 64350503
Portal vein thrombosis 31.10 15.31 42 118432 4949 64375309
Liver abscess 30.74 15.31 43 118431 5237 64375021
Pulmonary artery thrombosis 30.72 15.31 22 118452 1184 64379074
Type 2 diabetes mellitus 30.70 15.31 12 118462 34008 64346250
Toxic epidermal necrolysis 30.55 15.31 15 118459 37151 64343107
Oropharyngeal discomfort 30.40 15.31 43 118431 5292 64374966
Tooth disorder 30.30 15.31 3 118471 22399 64357859
Haematemesis 30.21 15.31 168 118306 46831 64333427
Temperature intolerance 29.76 15.31 54 118420 8201 64372057
Gastrooesophageal reflux disease 29.73 15.31 68 118406 83075 64297183
Hypersplenism 29.72 15.31 15 118459 422 64379836
Anaphylactoid reaction 29.72 15.31 40 118434 4698 64375560
Suffocation feeling 29.69 15.31 24 118450 1550 64378708
Full blood count abnormal 29.43 15.31 9 118465 29748 64350510
Hypothyroidism 29.41 15.31 19 118455 40438 64339820
Pelvic fluid collection 29.40 15.31 17 118457 631 64379627
Femur fracture 29.26 15.31 13 118461 34122 64346136
Neutropenic colitis 29.23 15.31 39 118435 4542 64375716
Perforation bile duct 29.21 15.31 8 118466 34 64380224
Hypophagia 29.21 15.31 147 118327 39440 64340818
Appendicitis noninfective 29.12 15.31 7 118467 15 64380243
Cytomegalovirus infection 29.11 15.31 16 118458 37183 64343075
Oral dysaesthesia 28.94 15.31 11 118463 152 64380106
Oedema peripheral 28.92 15.31 247 118227 210070 64170188
Eosinophilia 28.91 15.31 17 118457 38059 64342199
Hypotension 28.74 15.31 909 117565 380065 64000193
Thrombocytopenic purpura 28.73 15.31 27 118447 2135 64378123
Loss of personal independence in daily activities 28.64 15.31 56 118418 72398 64307860
Pelvic abscess 28.35 15.31 25 118449 1820 64378438
Failure to anastomose 28.28 15.31 12 118462 224 64380034
Perineal disorder 28.23 15.31 7 118467 18 64380240
Osteomyelitis 27.91 15.31 8 118466 27579 64352679
Sciatic nerve palsy 27.86 15.31 9 118465 74 64380184
Death 27.74 15.31 675 117799 482030 63898228
Medical device site extravasation 27.66 15.31 6 118468 6 64380252
Oesophagitis 27.56 15.31 95 118379 21535 64358723
Hepatectomy 27.53 15.31 11 118463 175 64380083
Granulocyte count decreased 27.39 15.31 21 118453 1255 64379003
Nephrolithiasis 27.29 15.31 24 118450 43659 64336599
Wound dehiscence 27.25 15.31 43 118431 5831 64374427
Hypercreatinaemia 27.21 15.31 12 118462 247 64380011
Obesity 27.18 15.31 3 118471 20559 64359699
Oropharyngeal spasm 27.08 15.31 12 118462 250 64380008
Tumour ulceration 27.03 15.31 11 118463 184 64380074
Haemolytic uraemic syndrome 26.84 15.31 35 118439 3986 64376272
Sensation of foreign body 26.84 15.31 37 118437 4445 64375813
Impaired quality of life 26.80 15.31 45 118429 6426 64373832
Koebner phenomenon 26.79 15.31 8 118466 49 64380209
Blood glucose decreased 26.78 15.31 5 118469 23118 64357140
Fistula of small intestine 26.61 15.31 16 118458 639 64379619
Respiratory arrest 26.55 15.31 35 118439 52950 64327308
Nephrotic syndrome 26.48 15.31 56 118418 9511 64370747
Hyperfibrinolysis 26.31 15.31 7 118467 26 64380232
Device issue 26.01 15.31 5 118469 22643 64357615
Ear pain 25.97 15.31 7 118467 25129 64355129
Full blood count decreased 25.91 15.31 5 118469 22577 64357681
Retching 25.89 15.31 74 118400 15182 64365076
Heart rate irregular 25.86 15.31 9 118465 27404 64352854
Necrotising oesophagitis 25.84 15.31 16 118458 674 64379584
Atypical haemolytic uraemic syndrome 25.80 15.31 16 118458 676 64379582
Acute polyneuropathy 25.56 15.31 13 118461 372 64379886
Respiratory distress 25.40 15.31 174 118300 52157 64328101
Hyperaemia 25.35 15.31 28 118446 2681 64377577
Hypoacusis 25.27 15.31 8 118466 25859 64354399
Blood creatine phosphokinase increased 25.15 15.31 43 118431 58515 64321743
Localised infection 25.05 15.31 12 118462 30149 64350109
Drug ineffective for unapproved indication 24.94 15.31 13 118461 31120 64349138
Skin laceration 24.85 15.31 7 118467 24410 64355848
Tonic clonic movements 24.83 15.31 24 118450 1965 64378293
Cholestasis 24.71 15.31 154 118320 44718 64335540
Hepatic encephalopathy 24.68 15.31 90 118384 20976 64359282
Subacute cutaneous lupus erythematosus 24.48 15.31 29 118445 2996 64377262
Sinus bradycardia 24.37 15.31 6 118468 22887 64357371
Tendonitis 24.33 15.31 4 118470 20278 64359980
Fear 24.15 15.31 4 118470 20167 64360091
Female genital tract fistula 24.06 15.31 27 118447 2631 64377627
Haemorrhage intracranial 24.03 15.31 7 118467 23877 64356381
Gastric varices haemorrhage 23.99 15.31 12 118462 331 64379927
Retroperitoneal abscess 23.96 15.31 12 118462 332 64379926
Adverse drug reaction 23.85 15.31 29 118445 45435 64334823
Vasospasm 23.64 15.31 17 118457 921 64379337
Hypoaesthesia oral 23.50 15.31 60 118414 11520 64368738
Proctitis 23.47 15.31 29 118445 3130 64377128
Limb injury 23.45 15.31 7 118467 23498 64356760
Haemolysis 23.24 15.31 58 118416 10981 64369277
Fatigue 23.17 15.31 1132 117342 747598 63632660
Perihepatic abscess 23.13 15.31 9 118465 133 64380125
Obstruction gastric 23.04 15.31 20 118454 1426 64378832
Allodynia 23.01 15.31 19 118455 1264 64378994
Catheter site extravasation 23.01 15.31 12 118462 362 64379896
Livedo reticularis 22.86 15.31 31 118443 3666 64376592
Carbohydrate antigen 19-9 increased 22.86 15.31 12 118462 367 64379891
Organising pneumonia 22.78 15.31 51 118423 9004 64371254
Chest discomfort 22.76 15.31 319 118155 115787 64264471
Epistaxis 22.74 15.31 278 118196 97853 64282405
Acral peeling skin syndrome 22.65 15.31 7 118467 49 64380209
Product substitution issue 22.64 15.31 3 118471 17858 64362400
Bradycardia 22.60 15.31 126 118348 118093 64262165
Gastrointestinal stoma complication 22.57 15.31 24 118450 2202 64378056
Hyperlipasaemia 22.52 15.31 17 118457 993 64379265
Cytopenia 22.44 15.31 71 118403 15400 64364858
Interventricular septum rupture 22.40 15.31 6 118468 23 64380235
Surgery 22.27 15.31 12 118462 28201 64352057
Hepatic lesion 22.15 15.31 39 118435 5785 64374473
Multiple sclerosis 22.14 15.31 4 118470 18937 64361321
Pulmonary hypertension 22.12 15.31 28 118446 43111 64337147
Intervertebral disc protrusion 22.07 15.31 5 118469 20186 64360072
Renal hydrocele 22.00 15.31 6 118468 25 64380233
Venous thrombosis limb 21.97 15.31 31 118443 3806 64376452
Dry eye 21.97 15.31 13 118461 29006 64351252
Cardiomegaly 21.96 15.31 8 118466 23676 64356582
Hepatic function abnormal 21.90 15.31 197 118277 64116 64316142
Blood alkaline phosphatase abnormal 21.80 15.31 15 118459 757 64379501
Platelet count increased 21.75 15.31 4 118470 18692 64361566
Pigmentation disorder 21.72 15.31 34 118440 4578 64375680
Fingerprint loss 21.62 15.31 7 118467 58 64380200
Metastases to muscle 21.62 15.31 11 118463 315 64379943
Blood pressure diastolic decreased 21.60 15.31 7 118467 22294 64357964
Premature delivery 21.57 15.31 4 118470 18585 64361673
Eczema 21.55 15.31 14 118460 29706 64350552
Cardiospasm 21.45 15.31 6 118468 28 64380230
Hand-foot-genital syndrome 21.38 15.31 5 118469 9 64380249
Pain in jaw 21.38 15.31 26 118448 40729 64339529
Musculoskeletal pain 21.35 15.31 77 118397 81217 64299041
Hypersomnia 21.32 15.31 5 118469 19712 64360546
Limbic encephalitis 21.25 15.31 14 118460 657 64379601
Gallbladder disorder 21.25 15.31 3 118471 17027 64363231
Aortitis 21.22 15.31 17 118457 1084 64379174
Gait inability 21.21 15.31 28 118446 42340 64337918
Hepatic vein stenosis 21.21 15.31 7 118467 62 64380196
Prostatic calcification 21.21 15.31 7 118467 62 64380196
Abdominal wall oedema 21.21 15.31 4 118470 0 64380258
Hallucination, auditory 21.10 15.31 3 118471 16936 64363322
Cardiac ventricular disorder 21.09 15.31 11 118463 332 64379926
Hepatic infarction 21.08 15.31 15 118459 799 64379459
Cachexia 21.08 15.31 50 118424 9167 64371091
Ischiorectal hernia 21.03 15.31 5 118469 10 64380248
Cerebrovascular accident 21.02 15.31 157 118317 137426 64242832
Colitis ulcerative 20.98 15.31 8 118466 23020 64357238
Rectal cancer metastatic 20.96 15.31 12 118462 437 64379821
Loss of consciousness 20.95 15.31 386 118088 147979 64232279
Adverse event 20.92 15.31 25 118449 39464 64340794
Protein urine 20.82 15.31 18 118456 1276 64378982
Ventricular fibrillation 20.81 15.31 93 118381 23767 64356491
Implant site dehiscence 20.79 15.31 6 118468 32 64380226
Tremor 20.71 15.31 385 118089 147845 64232413
Swelling face 20.66 15.31 49 118425 59117 64321141
Blood potassium increased 20.59 15.31 11 118463 25969 64354289
Hemiparaesthesia 20.51 15.31 8 118466 119 64380139
Chronic myeloid leukaemia 20.43 15.31 28 118446 3346 64376912
Hypocapnia 20.38 15.31 13 118461 577 64379681
Congestive cardiomyopathy 20.38 15.31 53 118421 10291 64369967
Gout 20.25 15.31 7 118467 21406 64358852
Fistula 20.25 15.31 51 118423 9710 64370548
Drug eruption 20.09 15.31 22 118452 36114 64344144
Musculoskeletal discomfort 20.00 15.31 3 118471 16274 64363984
Diaphragmatic paralysis 20.00 15.31 16 118458 1018 64379240
Cholelithiasis 19.93 15.31 33 118441 45473 64334785
Seizure 19.93 15.31 203 118271 166689 64213569
Skin disorder 19.87 15.31 102 118372 27578 64352680
Hiatus hernia 19.80 15.31 6 118468 19951 64360307
Vocal cord paralysis 19.77 15.31 22 118452 2124 64378134
Peripheral ischaemia 19.76 15.31 46 118428 8332 64371926
Toothache 19.75 15.31 4 118470 17455 64362803
Catheter site bruise 19.73 15.31 10 118464 284 64379974
Tumour haemorrhage 19.67 15.31 28 118446 3465 64376793
Pneumonitis 19.64 15.31 159 118315 50206 64330052
Peripheral sensorimotor neuropathy 19.64 15.31 24 118450 2561 64377697
Palpitations 19.63 15.31 112 118362 104376 64275882
Labelled drug-drug interaction medication error 19.55 15.31 8 118466 22054 64358204
Gastric disorder 19.53 15.31 15 118459 29182 64351076
Macroglossia 19.49 15.31 16 118458 1056 64379202
Mucosal disorder 19.43 15.31 26 118448 3036 64377222
Pseudocirrhosis 19.33 15.31 13 118461 632 64379626
Oesophagobronchial fistula 19.26 15.31 9 118465 213 64380045
Delirium 19.21 15.31 64 118410 69130 64311128
Dry skin 19.14 15.31 160 118314 51001 64329257
Infusion site hypoaesthesia 19.13 15.31 5 118469 17 64380241
Anger 19.12 15.31 3 118471 15738 64364520
Pulmonary congestion 19.08 15.31 10 118464 23870 64356388
Metastases to diaphragm 19.05 15.31 6 118468 45 64380213
Skin discolouration 19.01 15.31 22 118452 35233 64345025
Therapeutic response unexpected 19.01 15.31 4 118470 16997 64363261
Chemotherapy cardiotoxicity attenuation 18.91 15.31 5 118469 18 64380240
Hyperthyroidism 18.90 15.31 5 118469 18174 64362084
Malaise 18.83 15.31 899 117575 395348 63984910
Monocytopenia 18.82 15.31 8 118466 150 64380108
Anal sphincter atony 18.78 15.31 10 118464 315 64379943
Induration 18.77 15.31 19 118455 1645 64378613
Pneumoperitoneum 18.73 15.31 24 118450 2687 64377571
Device related infection 18.71 15.31 108 118366 30518 64349740
No adverse event 18.69 15.31 15 118459 28546 64351712
Catabolic state 18.67 15.31 7 118467 93 64380165
Depressed mood 18.66 15.31 29 118445 40983 64339275
Soft tissue necrosis 18.57 15.31 13 118461 675 64379583
Musculoskeletal disorder 18.48 15.31 5 118469 17901 64362357
Neonatal asphyxia 18.44 15.31 4 118470 4 64380254
Intrahepatic portal hepatic venous fistula 18.44 15.31 4 118470 4 64380254
Inferior vena cava stenosis 18.40 15.31 6 118468 51 64380207
Pachymeningitis 18.34 15.31 9 118465 238 64380020
Rectal cancer recurrent 18.30 15.31 5 118469 21 64380237
Impaired work ability 18.26 15.31 3 118471 15216 64365042
Venoocclusive disease 18.25 15.31 29 118445 3956 64376302
Pancreatic neuroendocrine tumour metastatic 18.21 15.31 7 118467 100 64380158
Colorectal cancer recurrent 18.19 15.31 6 118468 53 64380205
Therapy interrupted 18.19 15.31 7 118467 20029 64360229
Liver function test increased 18.18 15.31 18 118456 30952 64349306
Impaired healing 18.15 15.31 54 118420 60419 64319839
Cerebral haemorrhage 18.09 15.31 42 118432 51048 64329210
Microangiopathic haemolytic anaemia 18.08 15.31 17 118457 1345 64378913
Mental impairment 17.96 15.31 4 118470 16339 64363919
Heart rate increased 17.88 15.31 107 118367 98568 64281690
Tetany 17.87 15.31 21 118453 2151 64378107
Metastases to ovary 17.84 15.31 9 118465 253 64380005
Pruritus 17.76 15.31 722 117752 311678 64068580
Venous injury 17.72 15.31 12 118462 590 64379668
Cerebral vasoconstriction 17.67 15.31 16 118458 1206 64379052
Amnesia 17.64 15.31 39 118435 48230 64332028
Immunodeficiency 17.61 15.31 4 118470 16120 64364138
Endometrial dysplasia 17.60 15.31 5 118469 25 64380233
Abdominal abscess 17.57 15.31 37 118437 6267 64373991
Splenic abscess 17.56 15.31 11 118463 473 64379785
Blood creatinine increased 17.54 15.31 162 118312 135620 64244638
Radiation interaction 17.53 15.31 6 118468 60 64380198
Tunnel vision 17.51 15.31 15 118459 1050 64379208
Metastases to retroperitoneum 17.49 15.31 10 118464 363 64379895
Product administration error 17.49 15.31 15 118459 27628 64352630
Extrapyramidal disorder 17.47 15.31 7 118467 19545 64360713
Gastrointestinal obstruction 17.43 15.31 17 118457 1408 64378850
VIth nerve disorder 17.28 15.31 5 118469 27 64380231
Disease recurrence 17.26 15.31 108 118366 31402 64348856
Restless legs syndrome 17.25 15.31 5 118469 17111 64363147
Chronic kidney disease 17.18 15.31 52 118422 57867 64322391
Gastrointestinal necrosis 17.17 15.31 32 118442 4960 64375298
Aortic intramural haematoma 17.15 15.31 7 118467 118 64380140
Motion sickness 17.13 15.31 13 118461 765 64379493
Peripheral nerve injury 17.12 15.31 12 118462 624 64379634
Renal disorder 17.07 15.31 24 118450 35341 64344917
Gastrointestinal mucosal necrosis 16.98 15.31 8 118466 193 64380065
Atrioventricular block complete 16.95 15.31 3 118471 14415 64365843
Sciatica 16.93 15.31 8 118466 20256 64360002
Nephritis allergic 16.92 15.31 12 118462 636 64379622
Night sweats 16.87 15.31 25 118449 36021 64344237
Autoimmune haemolytic anaemia 16.85 15.31 39 118435 7037 64373221
Mixed adenoneuroendocrine carcinoma 16.83 15.31 4 118470 8 64380250
Eye pain 16.77 15.31 20 118454 31605 64348653
Therapy cessation 16.75 15.31 21 118453 32468 64347790
Ichthyosis 16.73 15.31 7 118467 126 64380132
Amaurosis fugax 16.71 15.31 13 118461 794 64379464
Post embolisation syndrome 16.70 15.31 6 118468 70 64380188
Gastric varices 16.65 15.31 11 118463 519 64379739
Laboratory test abnormal 16.56 15.31 12 118462 24051 64356207
Lacrimation disorder 16.51 15.31 4 118470 9 64380249
Blood triglycerides increased 16.46 15.31 7 118467 18859 64361399
Oesophageal fistula 16.39 15.31 9 118465 302 64379956
Fixed eruption 16.33 15.31 20 118454 2139 64378119
Adenocarcinoma of colon 16.31 15.31 31 118443 4877 64375381
Aplasia 16.21 15.31 38 118436 6915 64373343
Aplastic anaemia 16.14 15.31 3 118471 13917 64366341
Feeling cold 16.13 15.31 86 118388 23592 64356666
Lymphadenopathy mediastinal 16.11 15.31 27 118447 3849 64376409
Infection 15.98 15.31 241 118233 184639 64195619
Eyelid ptosis 15.97 15.31 46 118428 9479 64370779
Mental disorder 15.95 15.31 15 118459 26430 64353828
Dyskinesia 15.95 15.31 30 118444 39358 64340900
Neuronal neuropathy 15.91 15.31 3 118471 0 64380258
Gastrointestinal stoma output increased 15.82 15.31 8 118466 226 64380032
Coombs positive haemolytic anaemia 15.74 15.31 13 118461 865 64379393
Subdural haematoma 15.68 15.31 17 118457 28037 64352221
Tumour marker increased 15.65 15.31 25 118449 3425 64376833
Lymphangiosis carcinomatosa 15.64 15.31 18 118456 1803 64378455
Oedema 15.47 15.31 102 118372 91833 64288425
Myoclonus 15.45 15.31 14 118460 25104 64355154
Liver injury 15.41 15.31 101 118373 29831 64350427
Abdominal sepsis 15.41 15.31 18 118456 1832 64378426
Ankle fracture 15.38 15.31 4 118470 14706 64365552
Sense of oppression 15.38 15.31 16 118458 1431 64378827

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01XA03 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
OTHER ANTINEOPLASTIC AGENTS
Platinum compounds
FDA EXT N0000175073 Platinum-containing Compounds
FDA EPC N0000175413 Platinum-based Drug
MeSH PA D000970 Antineoplastic Agents
CHEBI has role CHEBI:25435 mutagens
CHEBI has role CHEBI:35610 antineoplastic agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Metastasis from malignant tumor of colon indication 314998002
Small intestine cancer indication 363509000 DOID:10154
Lymph Node Positive Colorectal Carcinoma indication
Malignant tumor of colon off-label use 363406005 DOID:219
Malignant tumor of testis off-label use 363449006 DOID:2998
Adenocarcinoma of pancreas off-label use 700423003 DOID:4074
Fibrosis of lung contraindication 51615001 DOID:3770
Interstitial pneumonia contraindication 64667001
Kidney disease contraindication 90708001 DOID:557
Liver function tests abnormal contraindication 166603001
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Peripheral nerve disease contraindication 302226006
Breastfeeding (mother) contraindication 413712001




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4021355 VUID
N0000148774 NUI
D01790 KEGG_DRUG
4021355 VANDF
C0069717 UMLSCUI
CHEBI:31941 CHEBI
1PT PDB_CHEM_ID
CHEMBL414804 ChEMBL_ID
D000077150 MESH_DESCRIPTOR_UI
DB00526 DRUGBANK_ID
7433 IUPHAR_LIGAND_ID
6012 INN_ID
04ZR38536J UNII
9887053 PUBCHEM_CID
32592 RXNORM
165344 MMSL
16916 MMSL
d04811 MMSL
007166 NDDF
327032007 SNOMEDCT_US
395814003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-3985 INJECTION, SOLUTION, CONCENTRATE 50 mg INTRAVENOUS NDA 28 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-3986 INJECTION, SOLUTION, CONCENTRATE 100 mg INTRAVENOUS NDA 28 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 0781-3315 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 29 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 0781-3317 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 29 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 0781-9315 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 28 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 0781-9317 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 28 sections
OXALIPLATIN HUMAN PRESCRIPTION DRUG LABEL 1 0955-1725 INJECTION, SOLUTION, CONCENTRATE 5 mg INTRAVENOUS NDA AUTHORIZED GENERIC 33 sections
OXALIPLATIN HUMAN PRESCRIPTION DRUG LABEL 1 0955-1727 INJECTION, SOLUTION, CONCENTRATE 5 mg INTRAVENOUS NDA AUTHORIZED GENERIC 33 sections
OXALIPLATIN HUMAN PRESCRIPTION DRUG LABEL 1 0955-1731 INJECTION, SOLUTION, CONCENTRATE 5 mg INTRAVENOUS NDA AUTHORIZED GENERIC 33 sections
OXALIPLATIN HUMAN PRESCRIPTION DRUG LABEL 1 0955-1733 INJECTION, SOLUTION, CONCENTRATE 5 mg INTRAVENOUS NDA AUTHORIZED GENERIC 33 sections
oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 16714-727 INJECTION 5 mg INTRAVENOUS ANDA 27 sections
oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 16714-728 INJECTION 5 mg INTRAVENOUS ANDA 27 sections
oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 16729-332 INJECTION, SOLUTION, CONCENTRATE 5 mg INTRAVENOUS ANDA 30 sections
oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 25021-233 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 28 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 43066-014 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 28 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 43066-018 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 28 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 45963-611 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 5 mg INTRAVENOUS ANDA 20 sections
Oxaliplatin Human Prescription Drug Label 1 47335-046 INJECTION, SOLUTION, CONCENTRATE 50 mg INTRAVENOUS ANDA 27 sections
Oxaliplatin Human Prescription Drug Label 1 47335-047 INJECTION, SOLUTION, CONCENTRATE 100 mg INTRAVENOUS ANDA 27 sections
Oxaliplatin Human Prescription Drug Label 1 47335-176 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 50 mg INTRAVENOUS ANDA 28 sections
Oxaliplatin Human Prescription Drug Label 1 47335-178 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS ANDA 28 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 50742-405 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 26 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 50742-406 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 26 sections
Oxaliplatin Human Prescription Drug Label 1 55150-331 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 29 sections
Oxaliplatin Human Prescription Drug Label 1 55150-332 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 29 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 57277-001 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 26 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 57277-002 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 26 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 60505-6132 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 25 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 60505-6132 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 25 sections
Oxaliplatin HUMAN PRESCRIPTION DRUG LABEL 1 61703-363 INJECTION, SOLUTION, CONCENTRATE 5 mg INTRAVENOUS ANDA 33 sections