carboplatin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antineoplastic agents, platinum derivatives 4133 41575-94-4

Description:

MoleculeDescription

Synonyms:

  • paraplatin
  • carboplatin
An organoplatinum compound that possesses antineoplastic activity.
  • Molecular weight: 371.26
  • Formula: C6H12N2O4Pt
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 107.88
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 14 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 77 % Benet LZ, Broccatelli F, Oprea TI
Vd (Volume of distribution) 0.26 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 1 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Aug. 25, 2021 PMDA MYLAN SEIYAKU Ltd
March 3, 1989 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neutropenia 3554.25 12.46 3272 187041 221632 90216502
Myelosuppression 3404.99 12.46 1834 188479 51757 90386377
Malignant neoplasm progression 3339.78 12.46 2322 187991 104548 90333586
Febrile neutropenia 3182.48 12.46 2643 187670 155706 90282428
Disease progression 2522.36 12.46 2305 188008 154310 90283824
Anaemia 2301.07 12.46 3242 187071 349560 90088574
Thrombocytopenia 2125.79 12.46 2398 187915 206327 90231807
Pancytopenia 1699.01 12.46 1647 188666 118616 90319518
Neutrophil count decreased 1380.51 12.46 1168 189145 70364 90367770
Neuropathy peripheral 1181.92 12.46 1447 188866 135523 90302611
Erythema 1041.40 12.46 1786 188527 227460 90210674
Acute myeloid leukaemia 1010.33 12.46 596 189717 20044 90418090
Therapy partial responder 971.51 12.46 595 189718 21448 90416686
Myelodysplastic syndrome 895.17 12.46 554 189759 20349 90417785
Joint swelling 875.73 12.46 44 190269 503256 89934878
Neoplasm progression 855.06 12.46 725 189588 43761 90394373
Haematotoxicity 820.33 12.46 438 189875 12097 90426037
Pain 712.95 12.46 629 189684 995712 89442422
Flushing 688.11 12.46 888 189425 87603 90350531
Mucosal inflammation 682.43 12.46 718 189595 56907 90381227
Anaphylactic shock 671.43 12.46 546 189767 31071 90407063
Synovitis 669.09 12.46 4 190309 329748 90108386
Pemphigus 648.51 12.46 7 190306 326857 90111277
Glossodynia 624.75 12.46 10 190303 321769 90116365
Platelet count decreased 623.64 12.46 1069 189244 135900 90302234
Neutropenic sepsis 614.80 12.46 415 189898 17715 90420419
Systemic lupus erythematosus 612.51 12.46 37 190276 361859 90076275
Leukopenia 606.02 12.46 893 189420 99817 90338317
Weight increased 605.29 12.46 81 190232 417846 90020288
Hand deformity 589.49 12.46 6 190307 296356 90141778
Arthropathy 589.30 12.46 48 190265 366194 90071940
Rheumatoid arthritis 584.91 12.46 47 190266 362567 90075567
Contraindicated product administered 579.60 12.46 21 190292 320118 90118016
Swelling 568.50 12.46 98 190215 418960 90019174
Nasopharyngitis 554.89 12.46 94 190219 407010 90031124
Hypothyroidism 538.53 12.46 610 189703 52517 90385617
Bone marrow failure 528.56 12.46 480 189833 31741 90406393
Immune-mediated enterocolitis 520.43 12.46 236 190077 4521 90433613
Sinusitis 517.49 12.46 58 190255 343030 90095104
Immune-mediated hepatic disorder 516.17 12.46 179 190134 1613 90436521
Hepatic cytolysis 509.96 12.46 462 189851 30454 90407680
Therapeutic product effect decreased 503.12 12.46 18 190295 277553 90160581
Peripheral swelling 501.78 12.46 125 190188 412981 90025153
Wound 500.68 12.46 35 190278 302945 90135189
Abdominal discomfort 491.48 12.46 194 190119 477134 89961000
Colitis 471.82 12.46 655 189658 69287 90368847
Immune-mediated hypothyroidism 465.72 12.46 160 190153 1398 90436736
Psoriatic arthropathy 461.86 12.46 3 190310 228332 90209802
Product dose omission issue 461.52 12.46 41 190272 291646 90146488
Hypokalaemia 460.27 12.46 915 189398 130201 90307933
Helicobacter infection 458.76 12.46 3 190310 226847 90211287
Metastases to liver 454.68 12.46 420 189893 28387 90409747
Musculoskeletal stiffness 447.46 12.46 50 190263 296482 90141652
Maternal exposure during pregnancy 429.41 12.46 113 190200 359950 90078184
Immune-mediated adrenal insuficiency 418.73 12.46 135 190178 947 90437187
White blood cell count decreased 417.24 12.46 1017 189296 166092 90272042
Nausea 417.08 12.46 3847 186466 1106469 89331665
Duodenal ulcer perforation 405.73 12.46 13 190300 221275 90216859
Irritable bowel syndrome 404.40 12.46 6 190307 207442 90230692
Immune-mediated hepatitis 402.97 12.46 171 190142 2773 90435361
Pericarditis 401.46 12.46 48 190265 270103 90168031
Fibromyalgia 397.75 12.46 7 190306 206262 90231872
Headache 397.05 12.46 757 189556 861989 89576145
Hypomagnesaemia 390.52 12.46 426 189887 35162 90402972
Pneumonitis 384.21 12.46 469 189844 43701 90394433
Febrile bone marrow aplasia 381.51 12.46 244 190069 9494 90428640
Arthralgia 381.44 12.46 657 189656 777865 89660269
Polyneuropathy 381.36 12.46 320 189993 19021 90419113
Discomfort 376.57 12.46 62 190251 274273 90163861
Second primary malignancy 369.74 12.46 245 190068 10133 90428001
Hepatic enzyme increased 365.58 12.46 150 190163 360586 90077548
Blood cholesterol increased 358.70 12.46 19 190294 207993 90230141
Metastases to central nervous system 357.84 12.46 296 190017 17246 90420888
Ovarian cancer recurrent 356.77 12.46 132 190181 1458 90436676
Fall 355.78 12.46 294 190019 481516 89956618
Hyperthyroidism 346.76 12.46 296 190017 18014 90420120
Myocarditis 343.89 12.46 262 190051 13544 90424590
Peripheral sensory neuropathy 338.36 12.46 222 190091 9028 90429106
Blister 338.24 12.46 63 190250 254935 90183199
Mobility decreased 336.78 12.46 60 190253 250674 90187460
Dyspnoea 335.34 12.46 3063 187250 877892 89560242
Injury 334.21 12.46 20 190293 197329 90240805
Off label use 327.25 12.46 3640 186673 1098612 89339522
Skin toxicity 324.46 12.46 193 190120 6586 90431548
Vomiting 323.64 12.46 2787 187526 785506 89652628
Metastases to lung 318.23 12.46 266 190047 15725 90422409
Drug intolerance 312.38 12.46 288 190025 447303 89990831
Metastases to bone 305.76 12.46 320 189993 25185 90412949
Immune-mediated lung disease 300.55 12.46 122 190191 1758 90436376
Folliculitis 299.41 12.46 38 190275 204315 90233819
Treatment failure 297.31 12.46 133 190180 303795 90134339
Contusion 295.29 12.46 81 190232 251135 90186999
Immune-mediated dermatitis 291.53 12.46 99 190214 832 90437302
Asthma 290.46 12.46 75 190238 242085 90196049
Diarrhoea 282.15 12.46 3110 187203 936080 89502054
Lower respiratory tract infection 276.15 12.46 91 190222 250568 90187566
Type 2 diabetes mellitus 274.29 12.46 48 190265 203196 90234938
Impaired healing 272.48 12.46 77 190236 234122 90204012
Dehydration 270.66 12.46 961 189352 193486 90244648
Osteoarthritis 269.06 12.46 44 190269 195686 90242448
Immune-mediated myocarditis 264.58 12.46 101 190212 1224 90436910
Migraine 263.51 12.46 42 190271 190350 90247784
Insomnia 256.64 12.46 195 190118 333279 90104855
Injection site pain 250.37 12.46 34 190279 173665 90264469
Wheezing 249.29 12.46 94 190219 237986 90200148
Proteinuria 248.91 12.46 275 190038 23016 90415118
Sepsis 248.80 12.46 887 189426 178927 90259207
Joint range of motion decreased 248.46 12.46 8 190305 135635 90302499
Exposure during pregnancy 248.19 12.46 95 190218 238315 90199819
Sleep disorder 247.91 12.46 56 190257 197974 90240160
Depression 246.77 12.46 164 190149 300437 90137697
Tubulointerstitial nephritis 243.26 12.46 283 190030 25060 90413074
Ascites 241.64 12.46 391 189922 47349 90390785
Posterior reversible encephalopathy syndrome 237.42 12.46 263 190050 22076 90416058
Type I hypersensitivity 235.36 12.46 132 190181 4023 90434111
Overdose 234.25 12.46 28 190285 157681 90280453
Bursitis 233.46 12.46 10 190303 131644 90306490
Acute kidney injury 231.45 12.46 1302 189011 319085 90119049
Cardiotoxicity 227.76 12.46 190 190123 11199 90426935
Radiotherapy 226.01 12.46 82 190231 853 90437281
Metastases to peritoneum 224.55 12.46 128 190185 4027 90434107
Pulmonary embolism 224.34 12.46 694 189619 130126 90308008
Thyroiditis 223.73 12.46 122 190191 3515 90434619
Rash maculo-papular 223.37 12.46 347 189966 40586 90397548
Epistaxis 221.86 12.46 527 189786 84598 90353536
Memory impairment 221.85 12.46 69 190244 197175 90240959
Tumour lysis syndrome 220.85 12.46 185 190128 10967 90427167
Pleural effusion 216.59 12.46 620 189693 111371 90326763
Metastases to lymph nodes 215.30 12.46 186 190127 11503 90426631
Condition aggravated 214.01 12.46 596 189717 594949 89843185
C-reactive protein abnormal 212.46 12.46 14 190299 127415 90310719
Palmar-plantar erythrodysaesthesia syndrome 211.07 12.46 277 190036 27746 90410388
Hepatic function abnormal 207.43 12.46 359 189954 45929 90392205
Asthenia 205.40 12.46 1862 188451 531889 89906245
Muscle spasms 204.58 12.46 139 190174 251744 90186390
Adrenal insufficiency 202.87 12.46 281 190032 29640 90408494
Neurotoxicity 201.51 12.46 237 190076 21230 90416904
Disease recurrence 201.01 12.46 316 189997 37337 90400797
Psoriasis 199.10 12.46 35 190278 147719 90290415
Product use issue 195.75 12.46 243 190070 329676 90108458
Anaphylactic reaction 194.58 12.46 510 189803 87014 90351120
Gastrointestinal perforation 190.97 12.46 117 190196 4215 90433919
Cytopenia 189.88 12.46 208 190105 17241 90420893
Pyrexia 188.55 12.46 2167 188146 658318 89779816
Loss of personal independence in daily activities 188.36 12.46 30 190283 136075 90302059
Pain in extremity 188.19 12.46 417 189896 450112 89988022
Confusional state 187.60 12.46 327 189986 385878 90052256
Obesity 187.11 12.46 8 190305 105499 90332635
Facet joint syndrome 186.94 12.46 4 190309 98385 90339749
Drug ineffective 184.45 12.46 1941 188372 1382357 89055777
Large intestine perforation 179.81 12.46 155 190158 9557 90428577
Sciatica 178.75 12.46 8 190305 101374 90336760
Gait inability 178.17 12.46 44 190269 146412 90291722
Immune-mediated hypophysitis 176.71 12.46 59 190254 468 90437666
Hypophysitis 176.03 12.46 92 190221 2428 90435706
Road traffic accident 176.00 12.46 13 190300 107613 90330521
Neoplasm recurrence 175.05 12.46 100 190213 3159 90434975
Neutropenic colitis 167.74 12.46 106 190207 4037 90434097
Arthritis 165.43 12.46 72 190241 167243 90270891
Lower limb fracture 163.34 12.46 3 190310 85010 90353124
Hypertransaminasaemia 160.78 12.46 182 190131 15643 90422491
Chest discomfort 160.24 12.46 645 189668 137720 90300414
Hydronephrosis 158.38 12.46 161 190152 12241 90425893
Oxygen saturation decreased 157.90 12.46 541 189772 106942 90331192
Ileus 157.51 12.46 184 190129 16362 90421772
Hypercholesterolaemia 157.25 12.46 15 190298 100877 90337257
Hospitalisation 156.77 12.46 38 190275 128062 90310072
Radiation pneumonitis 156.56 12.46 77 190236 1781 90436353
Thrombotic microangiopathy 156.46 12.46 179 190134 15564 90422570
Lichenoid keratosis 155.87 12.46 85 190228 2449 90435685
Red blood cell sedimentation rate increased 154.44 12.46 4 190309 82591 90355543
Oesophagitis 152.96 12.46 185 190128 17064 90421070
Toxic skin eruption 152.81 12.46 177 190136 15597 90422537
Non-small cell lung cancer 152.61 12.46 102 190211 4279 90433855
Ill-defined disorder 151.47 12.46 101 190212 184790 90253344
Injection site reaction 150.92 12.46 11 190302 92069 90346065
Drug resistance 150.83 12.46 247 190066 30202 90407932
Injection site erythema 149.99 12.46 16 190297 98486 90339648
Drug abuse 146.83 12.46 6 190307 82341 90355793
Influenza 145.69 12.46 55 190258 139209 90298925
Liver injury 144.06 12.46 90 190223 170477 90267657
Prescribed overdose 143.31 12.46 18 190295 97607 90340527
Abdominal pain 143.19 12.46 1363 188950 394358 90043776
Immune-mediated hyperthyroidism 141.78 12.46 46 190267 330 90437804
Palmar erythema 139.90 12.46 72 190241 1839 90436295
Hepatotoxicity 139.66 12.46 302 190011 45540 90392594
Inflammation 139.12 12.46 103 190210 178489 90259645
Drug hypersensitivity 136.99 12.46 506 189807 463103 89975031
Metastasis 136.64 12.46 109 190204 6028 90432106
Night sweats 136.13 12.46 50 190263 128716 90309418
Metastases to meninges 135.04 12.46 89 190224 3646 90434488
Enterocolitis 133.63 12.46 136 190177 10354 90427780
Immune-mediated thyroiditis 131.99 12.46 47 190266 461 90437673
Cytokine release syndrome 130.64 12.46 221 190092 27752 90410382
Suicide attempt 129.56 12.46 7 190306 75392 90362742
Gastrooesophageal reflux disease 129.47 12.46 96 190217 166241 90271893
Hypopituitarism 128.20 12.46 66 190247 1687 90436447
Feeling hot 127.38 12.46 407 189906 77601 90360533
Bronchitis 125.98 12.46 83 190230 152844 90285290
Product quality issue 125.75 12.46 11 190302 79314 90358820
Live birth 125.32 12.46 11 190302 79096 90359038
Gait disturbance 125.10 12.46 222 190091 260274 90177860
Septic shock 124.82 12.46 425 189888 83735 90354399
Tachycardia 124.60 12.46 657 189656 157016 90281118
Bronchospasm 123.51 12.46 183 190130 20526 90417608
Adrenocorticotropic hormone deficiency 123.32 12.46 50 190263 718 90437416
Nephritis 122.53 12.46 79 190234 3116 90435018
Ejection fraction decreased 122.06 12.46 207 190106 26046 90412088
Amnesia 121.89 12.46 38 190275 108467 90329667
Dry mouth 121.72 12.46 124 190189 183935 90254199
Immune-mediated pancreatitis 121.52 12.46 41 190272 337 90437797
Renal salt-wasting syndrome 121.28 12.46 43 190270 416 90437718
Hypotension 120.74 12.46 1127 189186 324270 90113864
Illness 120.59 12.46 15 190298 81954 90356180
Immune-mediated arthritis 120.08 12.46 38 190275 249 90437885
Joint stiffness 118.00 12.46 13 190300 78029 90360105
Agranulocytosis 117.57 12.46 240 190073 34762 90403372
Renal tubular disorder 117.36 12.46 77 190236 3130 90435004
Peripheral venous disease 117.23 12.46 18 190295 83903 90354231
Intentional product use issue 116.17 12.46 172 190141 216720 90221414
Pregnancy 116.02 12.46 3 190310 62044 90376090
Embolism 115.49 12.46 120 190193 9361 90428773
Autoimmune disorder 115.49 12.46 13 190300 76731 90361403
Immune-mediated nephritis 112.62 12.46 41 190272 431 90437703
Gastrointestinal toxicity 112.06 12.46 118 190195 9349 90428785
Death 111.76 12.46 1456 188857 455095 89983039
Interstitial lung disease 110.82 12.46 383 189930 76022 90362112
Hyponatraemia 110.74 12.46 564 189749 132974 90305160
Small intestinal obstruction 108.91 12.46 175 190138 21059 90417075
Recall phenomenon 108.57 12.46 47 190266 802 90437332
Anxiety 108.10 12.46 314 189999 309458 90128676
Immune-mediated adverse reaction 107.83 12.46 47 190266 816 90437318
Acquired gene mutation 107.76 12.46 53 190260 1226 90436908
Decreased appetite 106.91 12.46 1235 189078 375305 90062829
Prescribed underdose 104.99 12.46 16 190297 75003 90363131
Wound infection 104.82 12.46 46 190267 106356 90331778
Musculoskeletal pain 104.80 12.46 123 190190 171128 90267006
Glucocorticoid deficiency 104.74 12.46 41 190272 534 90437600
Injection site swelling 104.58 12.46 5 190308 59834 90378300
Nephropathy toxic 104.31 12.46 131 190182 12557 90425577
Constipation 103.91 12.46 971 189342 279424 90158710
Stress 103.88 12.46 22 190291 81373 90356761
Renal tubular necrosis 103.65 12.46 140 190173 14415 90423719
Immune-mediated renal disorder 103.23 12.46 32 190281 194 90437940
Intentional product misuse 103.14 12.46 30 190283 89574 90348560
Papilloedema 102.82 12.46 82 190231 4533 90433601
Blepharospasm 102.49 12.46 3 190310 55442 90382692
Haemolytic anaemia 101.35 12.46 124 190189 11573 90426561
Urogenital fistula 100.79 12.46 38 190275 444 90437690
Suicidal ideation 100.56 12.46 17 190296 73838 90364296
Microvascular coronary artery disease 99.81 12.46 33 190280 253 90437881
Dermatitis acneiform 98.99 12.46 92 190221 6262 90431872
Deep vein thrombosis 98.87 12.46 418 189895 91202 90346932
Dermatitis bullous 98.66 12.46 115 190198 10201 90427933
Bone erosion 97.53 12.46 3 190310 53018 90385116
Aortitis 96.34 12.46 50 190263 1300 90436834
Autoimmune haemolytic anaemia 96.29 12.46 86 190227 5559 90432575
Injection site bruising 96.07 12.46 3 190310 52304 90385830
Haemophagocytic lymphohistiocytosis 95.65 12.46 139 190174 15320 90422814
Intestinal perforation 95.04 12.46 131 190182 13750 90424384
Ovarian cancer metastatic 93.88 12.46 46 190267 1055 90437079
Urticaria 93.82 12.46 339 189974 312395 90125739
Product use in unapproved indication 92.83 12.46 1097 189216 335139 90102995
Alopecia 92.00 12.46 635 189678 494436 89943698
Fluid retention 91.77 12.46 35 190278 88056 90350078
Metastatic neoplasm 91.48 12.46 78 190235 4737 90433397
Feeling abnormal 91.13 12.46 131 190182 167104 90271030
Dizziness 90.76 12.46 796 189517 588488 89849646
Diffuse large B-cell lymphoma recurrent 90.20 12.46 68 190245 3458 90434676
Adverse drug reaction 89.97 12.46 68 190245 116633 90321501
Malignant pleural effusion 89.06 12.46 63 190250 2901 90435233
Lymphangiosis carcinomatosa 88.99 12.46 51 190262 1621 90436513
Device related thrombosis 88.38 12.46 55 190258 2038 90436096
Somnolence 87.58 12.46 193 190120 208891 90229243
Inappropriate antidiuretic hormone secretion 85.70 12.46 150 190163 19355 90418779
Osteoporosis 85.62 12.46 48 190265 96483 90341651
Neutrophil count abnormal 84.89 12.46 70 190243 4058 90434076
Underdose 84.25 12.46 8 190305 54009 90384125
Gastrointestinal disorder 83.95 12.46 268 190045 256419 90181715
Ototoxicity 83.92 12.46 52 190261 1912 90436222
Hypocalcaemia 83.25 12.46 236 190077 42132 90396002
Tumour pseudoprogression 82.77 12.46 37 190276 684 90437450
Hypoaesthesia 82.55 12.46 359 189954 313851 90124283
Breast cancer recurrent 82.51 12.46 78 190235 5425 90432709
Adverse event 82.39 12.46 75 190238 117343 90320791
Secondary cerebellar degeneration 82.19 12.46 21 190292 53 90438081
Eastern Cooperative Oncology Group performance status worsened 81.99 12.46 51 190262 1888 90436246
Bicytopenia 81.88 12.46 66 190247 3705 90434429
Subileus 81.72 12.46 65 190248 3579 90434555
Troponin increased 81.57 12.46 119 190194 13162 90424972
Blood pressure fluctuation 81.12 12.46 8 190305 52405 90385729
Stress cardiomyopathy 81.06 12.46 119 190194 13236 90424898
Upper respiratory tract infection 80.85 12.46 90 190223 128228 90309906
Coeliac disease 80.38 12.46 3 190310 44607 90393527
Throat tightness 79.46 12.46 185 190128 29299 90408835
Breast cancer metastatic 79.37 12.46 126 190187 15006 90423128
Infusion related hypersensitivity reaction 79.30 12.46 35 190278 627 90437507
Sense of oppression 79.25 12.46 41 190272 1059 90437075
Cervix carcinoma recurrent 78.46 12.46 25 190288 168 90437966
Granulocyte count decreased 78.07 12.46 54 190259 2398 90435736
Laryngitis 77.89 12.46 8 190305 50745 90387389
Joint dislocation 77.03 12.46 4 190309 44578 90393556
Hypoxia 76.32 12.46 328 189985 72071 90366063
Neutropenic infection 75.03 12.46 47 190266 1762 90436372
EGFR gene mutation 74.66 12.46 28 190285 322 90437812
Enterocolitis infectious 74.55 12.46 49 190264 1998 90436136
Alveolar soft part sarcoma 74.51 12.46 21 190292 86 90438048
Medication error 73.78 12.46 43 190270 84609 90353525
Laryngospasm 73.78 12.46 59 190254 3274 90434860
Peripheral motor neuropathy 73.74 12.46 48 190265 1925 90436209
Immune-mediated gastritis 73.52 12.46 24 190289 176 90437958
Dyspepsia 72.69 12.46 196 190117 197964 90240170
Disability 72.53 12.46 3 190310 40742 90397392
Back injury 72.46 12.46 7 190306 46615 90391519
Lupus-like syndrome 71.70 12.46 9 190304 48837 90389297
Disseminated intravascular coagulation 71.53 12.46 147 190166 21391 90416743
Sedation 70.40 12.46 9 190304 48162 90389972
Pericardial effusion 70.27 12.46 203 190110 36630 90401504
Metastases to skin 70.19 12.46 48 190265 2092 90436042
Venous thrombosis 69.10 12.46 71 190242 5466 90432668
Drug interaction 68.33 12.46 323 189990 276130 90162004
Myasthenic syndrome 68.07 12.46 27 190286 365 90437769
Bone pain 67.80 12.46 284 190029 61699 90376435
Hepatic cirrhosis 67.79 12.46 24 190289 63229 90374905
Cystitis haemorrhagic 67.55 12.46 70 190243 5443 90432691
Endocarditis noninfective 67.19 12.46 19 190294 79 90438055
Hot flush 66.98 12.46 275 190038 59213 90378921
Fulminant type 1 diabetes mellitus 66.94 12.46 34 190279 844 90437290
Dysaesthesia 66.70 12.46 68 190245 5187 90432947
Anaphylactoid reaction 66.36 12.46 63 190250 4405 90433729
Paronychia 66.35 12.46 83 190230 7923 90430211
Abortion spontaneous 66.19 12.46 16 190297 54040 90384094
Hip arthroplasty 66.01 12.46 39 190274 76169 90361965
Erythema multiforme 65.66 12.46 103 190210 12143 90425991
Ovarian cancer 65.66 12.46 76 190237 6691 90431443
Tumour necrosis 65.54 12.46 35 190278 966 90437168
Hyperthermia 65.51 12.46 94 190219 10241 90427893
Cyanosis 64.86 12.46 133 190180 19322 90418812
Autoimmune colitis 64.48 12.46 32 190281 755 90437379
Myeloid leukaemia 63.98 12.46 28 190285 491 90437643
Onychomadesis 63.93 12.46 10 190303 45988 90392146
Cataract 63.72 12.46 36 190277 72056 90366078
Renal failure 63.52 12.46 482 189831 130525 90307609
Left ventricular dysfunction 63.40 12.46 112 190201 14557 90423577
Respiratory failure 63.32 12.46 446 189867 117972 90320162
Therapy interrupted 63.01 12.46 14 190299 50094 90388040
Intestinal obstruction 62.67 12.46 196 190117 36935 90401199
Radiation oesophagitis 62.51 12.46 27 190286 458 90437676
Neck pain 62.34 12.46 89 190224 113874 90324260
Infection 62.10 12.46 475 189838 361619 90076515
Hypoalbuminaemia 61.89 12.46 116 190197 15781 90422353
Muscle spasticity 61.56 12.46 3 190310 35319 90402815
Cortisol decreased 61.38 12.46 41 190272 1718 90436416
Cholestasis 60.71 12.46 191 190122 36108 90402026
Aplasia 60.66 12.46 57 190256 3934 90434200
Lung disorder 60.60 12.46 141 190172 149742 90288392
Cholangitis 60.39 12.46 75 190238 7107 90431027
BRCA1 gene mutation 60.12 12.46 16 190297 50 90438084
Renal impairment 59.89 12.46 403 189910 105018 90333116
Onychomycosis 59.73 12.46 5 190308 37371 90400763
Hallucination 59.65 12.46 32 190281 65927 90372207
Blood corticotrophin decreased 59.63 12.46 27 190286 515 90437619
Metastases to abdominal wall 59.43 12.46 20 190293 163 90437971
Pulmonary fibrosis 58.76 12.46 84 190229 107419 90330715
Small intestinal perforation 57.96 12.46 41 190272 1888 90436246
Recurrent cancer 57.59 12.46 45 190268 2414 90435720
Hepatitis 57.38 12.46 297 190016 70442 90367692
Performance status decreased 57.28 12.46 57 190256 4223 90433911
Incorrect dose administered 57.07 12.46 49 190264 78881 90359253
Nasal congestion 56.49 12.46 55 190258 83359 90354775
Pulmonary toxicity 56.37 12.46 93 190220 11438 90426696
Incorrect route of product administration 56.36 12.46 18 190295 50608 90387526
Carbohydrate antigen 125 increased 56.19 12.46 50 190263 3216 90434918
Encephalitis 56.06 12.46 91 190222 11043 90427091
Colitis ischaemic 55.61 12.46 96 190217 12250 90425884
Lymphadenopathy mediastinal 55.52 12.46 49 190264 3118 90435016
Frequent bowel movements 55.46 12.46 25 190288 56910 90381224
Nephrolithiasis 55.46 12.46 17 190296 49068 90389066
Choroidal infarction 55.27 12.46 17 190296 100 90438034
Pneumothorax 54.67 12.46 123 190190 19044 90419090
Haemoglobin decreased 54.59 12.46 550 189763 161406 90276728
Peritonitis 54.59 12.46 125 190188 19580 90418554
Radiation skin injury 54.43 12.46 32 190281 1068 90437066
Sleep apnoea syndrome 54.37 12.46 3 190310 31744 90406390
Subacute cutaneous lupus erythematosus 54.14 12.46 51 190262 3531 90434603
Malignant transformation 53.88 12.46 26 190287 576 90437558
Ischaemic stroke 53.20 12.46 133 190180 22033 90416101
Haematuria 52.28 12.46 177 190136 34760 90403374
Tumour embolism 52.12 12.46 18 190295 160 90437974
Basal cell carcinoma 51.92 12.46 5 190308 33384 90404750
Immune thrombocytopenia 51.58 12.46 97 190216 13229 90424905
Alanine aminotransferase increased 51.12 12.46 424 189889 117914 90320220
Venoocclusive liver disease 51.06 12.46 63 190250 5930 90432204
Serotonin syndrome 50.96 12.46 9 190304 37878 90400256
Face oedema 50.90 12.46 135 190178 23183 90414951
Immunodeficiency 50.63 12.46 14 190299 43220 90394914
Dysphagia 50.50 12.46 406 189907 111872 90326262
Mastectomy 50.44 12.46 39 190274 2060 90436074
Plasma cell myeloma 50.15 12.46 12 190301 40816 90397318
Abdominal pain upper 49.96 12.46 452 189861 332222 90105912
Polyneuropathy in malignant disease 49.69 12.46 15 190298 82 90438052
Lymphadenopathy 49.49 12.46 209 190104 45566 90392568
Electrolyte imbalance 49.34 12.46 135 190178 23610 90414524
Procedural pain 49.32 12.46 6 190307 33354 90404780
Tumour hyperprogression 48.94 12.46 17 190296 154 90437980
Pelvic abscess 48.94 12.46 38 190275 2020 90436114
Acute megakaryocytic leukaemia 48.52 12.46 13 190300 42 90438092
Axonal and demyelinating polyneuropathy 48.29 12.46 11 190302 13 90438121
Emphysematous cystitis 48.12 12.46 20 190293 307 90437827
Ear pain 47.93 12.46 31 190282 57671 90380463
Encephalopathy 47.86 12.46 209 190104 46235 90391899
Rectal perforation 47.85 12.46 23 190290 505 90437629
Transaminases increased 47.59 12.46 179 190134 37013 90401121
Injection site haemorrhage 47.51 12.46 3 190310 28315 90409819
Immune-mediated encephalitis 47.48 12.46 23 190290 514 90437620
Metastases to pleura 47.00 12.46 37 190276 2007 90436127
Macular degeneration 46.96 12.46 11 190302 37959 90400175
Type 1 diabetes mellitus 46.61 12.46 54 190259 4758 90433376
Cancer fatigue 46.58 12.46 17 190296 180 90437954
Lymphocele 46.57 12.46 26 190287 785 90437349
Autoimmune nephritis 46.36 12.46 21 190292 401 90437733
Paraneoplastic neurological syndrome 46.22 12.46 12 190301 33 90438101
Weight decreased 46.05 12.46 543 189770 379367 90058767
Systemic scleroderma 45.96 12.46 33 190280 1556 90436578
Blood creatinine increased 45.81 12.46 367 189946 101019 90337115
General physical health deterioration 45.71 12.46 1021 189292 354094 90084040
Dysgeusia 45.66 12.46 225 190088 52335 90385799
Joint injury 45.63 12.46 7 190306 32657 90405477
Immune-mediated myositis 45.55 12.46 39 190274 2382 90435752
Metastases to spine 44.92 12.46 47 190266 3696 90434438
Unevaluable event 44.84 12.46 30 190283 54818 90383316
Liver function test increased 44.71 12.46 68 190245 84787 90353347
Aspartate aminotransferase increased 44.55 12.46 369 189944 102568 90335566
Endometrial cancer recurrent 44.50 12.46 12 190301 40 90438094
Metastases to breast 44.29 12.46 20 190293 379 90437755
Skin reaction 44.19 12.46 111 190202 18442 90419692
Onycholysis 44.17 12.46 37 190276 2193 90435941
Visual impairment 44.08 12.46 137 190176 132228 90305906
Thrombophlebitis migrans 44.05 12.46 18 190295 264 90437870
Respiratory distress 43.81 12.46 180 190133 38766 90399368
Blood pressure systolic increased 43.69 12.46 35 190278 58310 90379824
Embolism arterial 43.69 12.46 28 190285 1093 90437041
Non-small cell lung cancer metastatic 43.67 12.46 25 190288 793 90437341
Eye pain 43.64 12.46 19 190294 44149 90393985
Cerebral infarction 43.61 12.46 139 190174 26457 90411677
Ulcer haemorrhage 43.54 12.46 3 190310 26318 90411816
Anastomotic leak 43.43 12.46 23 190290 624 90437510
Haemoptysis 43.16 12.46 161 190152 33159 90404975
Cold sweat 43.15 12.46 93 190220 13988 90424146
Heart rate decreased 42.76 12.46 30 190283 53475 90384659
Haemoglobin abnormal 42.71 12.46 63 190250 7037 90431097
Gastric disorder 42.64 12.46 9 190304 33375 90404759
Sinus disorder 42.56 12.46 10 190303 34437 90403697
Retinitis pigmentosa 42.50 12.46 15 190298 143 90437991
Shock 42.36 12.46 145 190168 28633 90409501
Hyperhidrosis 42.20 12.46 455 189858 135850 90302284
Hyperpyrexia 42.11 12.46 51 190262 4710 90433424
Treatment noncompliance 41.34 12.46 29 190284 51698 90386436
Tumour associated fever 41.21 12.46 20 190293 449 90437685
Skin candida 41.08 12.46 32 190281 1709 90436425
Aplastic anaemia 41.07 12.46 88 190225 13181 90424953
Femur fracture 40.74 12.46 23 190290 46059 90392075
Peritoneal disorder 40.68 12.46 22 190291 623 90437511
Device related infection 40.68 12.46 133 190180 25653 90412481
Lymphopenia 40.68 12.46 123 190190 22758 90415376
Cancer pain 40.39 12.46 46 190267 3979 90434155
Infected lymphocele 40.29 12.46 16 190297 217 90437917
Dermatomyositis 39.88 12.46 42 190271 3328 90434806
Urinary tract obstruction 39.83 12.46 35 190278 2214 90435920
Small cell lung cancer 39.76 12.46 32 190281 1792 90436342
Cardiac failure congestive 39.76 12.46 93 190220 98601 90339533
COVID-19 39.54 12.46 201 190112 168642 90269492
Hypervolaemia 39.51 12.46 10 190303 32747 90405387
Jugular vein thrombosis 39.50 12.46 43 190270 3538 90434596
Immune-mediated cytopenia 39.40 12.46 13 190300 99 90438035
Psychotic disorder 38.72 12.46 9 190304 31221 90406913
Hypophosphataemia 38.71 12.46 92 190221 14762 90423372
Acute promyelocytic leukaemia 38.64 12.46 26 190287 1103 90437031
Delirium 38.42 12.46 103 190210 104256 90333878
Fatigue 38.09 12.46 2009 188304 1152014 89286120
Hypertensive crisis 37.84 12.46 102 190211 17682 90420452
PIK3CA-activated mutation 37.12 12.46 26 190287 1178 90436956
Metastases to adrenals 37.06 12.46 24 190289 954 90437180
Ovarian epithelial cancer recurrent 37 12.46 9 190304 17 90438117
Guillain-Barre syndrome 36.93 12.46 47 190266 4565 90433569
Pain in jaw 36.92 12.46 28 190285 47957 90390177
Taste disorder 36.79 12.46 45 190268 61501 90376633
Head injury 36.71 12.46 10 190303 31178 90406956
Administration site extravasation 36.62 12.46 26 190287 1204 90436930
Influenza like illness 36.61 12.46 71 190242 80540 90357594
Injection site rash 36.60 12.46 4 190309 24169 90413965
Foot fracture 36.49 12.46 6 190307 26600 90411534
Lymphocyte count decreased 36.32 12.46 158 190155 34892 90403242
Dermatitis 36.31 12.46 116 190197 22104 90416030
Cholangitis sclerosing 36.24 12.46 33 190280 2188 90435946
Terminal agitation 36.18 12.46 7 190306 0 90438134
Pneumonia 36.12 12.46 1042 189271 637017 89801117
Chills 36.08 12.46 430 189883 131551 90306583
BRCA2 gene mutation 36.07 12.46 12 190301 94 90438040
Diffuse large B-cell lymphoma refractory 35.93 12.46 30 190283 1770 90436364
Chronic sinusitis 35.89 12.46 4 190309 23798 90414336
Laryngeal oedema 35.68 12.46 57 190256 6824 90431310
Bronchostenosis 35.59 12.46 19 190294 524 90437610
Anti-glomerular basement membrane disease 35.44 12.46 11 190302 67 90438067
Lung consolidation 35.14 12.46 47 190266 4793 90433341
Stomatitis 35.07 12.46 388 189925 274310 90163824
Secondary adrenocortical insufficiency 35.03 12.46 33 190280 2285 90435849
Product prescribing error 34.86 12.46 10 190303 30135 90407999
Malignant ascites 34.75 12.46 23 190290 949 90437185
Impaired quality of life 34.62 12.46 4 190309 23140 90414994
Acute monocytic leukaemia 34.55 12.46 13 190300 151 90437983
Mechanical ileus 34.49 12.46 21 190292 748 90437386
Nightmare 34.46 12.46 3 190310 21722 90416412
C-reactive protein increased 34.43 12.46 231 190082 181158 90256976
Abdominal abscess 34.15 12.46 49 190264 5338 90432796
Anisometropia 34.14 12.46 11 190302 77 90438057
Embolism venous 34.03 12.46 40 190273 3580 90434554
Acute erythroid leukaemia 34.02 12.46 13 190300 158 90437976
Madarosis 33.94 12.46 40 190273 3589 90434545
VIth nerve paralysis 33.94 12.46 22 190291 876 90437258
Autoimmune hypothyroidism 33.87 12.46 15 190298 271 90437863
Skin haemorrhage 33.78 12.46 3 190310 21377 90416757
Eye disorder 33.74 12.46 8 190305 27382 90410752
Ovarian disorder 33.73 12.46 22 190291 885 90437249
Vaginal fistula 33.73 12.46 19 190294 584 90437550
Carpal tunnel syndrome 33.72 12.46 5 190308 23923 90414211
Peripheral ischaemia 33.68 12.46 50 190263 5617 90432517
Iris atrophy 33.67 12.46 12 190301 118 90438016
Pelvic infection 33.59 12.46 16 190297 344 90437790
Non-small cell lung cancer recurrent 33.49 12.46 12 190301 120 90438014
Gastroenteritis viral 33.42 12.46 11 190302 30344 90407790
Extravasation 33.41 12.46 36 190277 2928 90435206
Immune-mediated endocrinopathy 33.41 12.46 12 190301 121 90438013
Therapeutic product effect incomplete 33.37 12.46 254 190059 193642 90244492
Maternal exposure timing unspecified 33.34 12.46 4 190309 22479 90415655
B-cell type acute leukaemia 33.26 12.46 19 190294 600 90437534
Metastases to bladder 33.04 12.46 14 190299 226 90437908
Urosepsis 33.04 12.46 109 190204 21123 90417011
Colitis ulcerative 33.02 12.46 47 190266 60219 90377915
Alopecia areata 32.99 12.46 30 190283 1985 90436149
Aortic thrombosis 32.89 12.46 25 190288 1287 90436847
Tachypnoea 32.80 12.46 109 190204 21200 90416934
Oedema 32.79 12.46 266 190047 200029 90238105
Radiation myelopathy 32.72 12.46 9 190304 33 90438101
Irritability 32.69 12.46 17 190296 35645 90402489
Metastases to kidney 32.33 12.46 14 190299 239 90437895
Transformation to acute myeloid leukaemia 32.03 12.46 16 190297 383 90437751
Capillary leak syndrome 31.88 12.46 34 190279 2733 90435401
Hepatic failure 31.66 12.46 166 190147 39562 90398572
Eye irritation 31.44 12.46 16 190297 33962 90404172
Optic atrophy 31.12 12.46 26 190287 1535 90436599
Gastric perforation 31.10 12.46 29 190284 1982 90436152
Blood pressure decreased 31.09 12.46 266 190047 74629 90363505
Hyperphosphaturia 30.99 12.46 9 190304 42 90438092
Optic glioma 30.86 12.46 7 190306 8 90438126
Autoimmune cholangitis 30.82 12.46 8 190305 22 90438112
Localised infection 30.76 12.46 16 190297 33546 90404588
Retinal pigment epitheliopathy 30.73 12.46 14 190299 271 90437863
Immune-mediated cholangitis 30.55 12.46 14 190299 275 90437859
Vena cava thrombosis 30.54 12.46 32 190281 2520 90435614
Axillary lymphadenectomy 30.53 12.46 11 190302 112 90438022
Immune-mediated cystitis 30.48 12.46 9 190304 45 90438089
Muscular weakness 30.47 12.46 282 190031 206384 90231750
Leukoencephalopathy 30.41 12.46 44 190269 4829 90433305
Febrile infection 30.40 12.46 29 190284 2040 90436094
Device dislocation 30.39 12.46 14 190299 31468 90406666
Chylothorax 30.25 12.46 16 190297 433 90437701
Cervix cancer metastatic 30.21 12.46 10 190303 77 90438057
Eczema 30.20 12.46 40 190273 52830 90385304
Tumour haemorrhage 30.10 12.46 29 190284 2065 90436069
Sinus congestion 30.09 12.46 10 190303 27414 90410720
Respiratory tract congestion 30.06 12.46 10 190303 27400 90410734
Cerebral ischaemia 29.89 12.46 54 190259 7142 90430992
Gamma-glutamyltransferase increased 29.84 12.46 158 190155 37794 90400340
Extremity necrosis 29.84 12.46 28 190285 1929 90436205
Dyskinesia 29.84 12.46 20 190293 36514 90401620
Neoplasm 29.84 12.46 61 190252 8842 90429292
Blast cells present 29.81 12.46 17 190296 535 90437599
Clostridium difficile colitis 29.70 12.46 123 190190 26583 90411551
Burkholderia pseudomallei infection 29.55 12.46 9 190304 51 90438083
Serous cystadenocarcinoma ovary 29.37 12.46 8 190305 28 90438106
Arterioenteric fistula 29.37 12.46 8 190305 28 90438106
Diastolic dysfunction 29.16 12.46 54 190259 7279 90430855
Metastases to pelvis 29.14 12.46 17 190296 559 90437575
Sinus tachycardia 29.14 12.46 128 190185 28385 90409749
Product storage error 29.06 12.46 4 190309 20237 90417897
Drug level increased 28.96 12.46 11 190302 27751 90410383
Mixed deafness 28.85 12.46 7 190306 13 90438121
Sopor 28.82 12.46 8 190305 24636 90413498
Megacolon 28.74 12.46 29 190284 2185 90435949
Hyperbilirubinaemia 28.72 12.46 79 190234 13857 90424277
Dermatitis atopic 28.63 12.46 7 190306 23465 90414669
Tremor 28.60 12.46 196 190117 152977 90285157
Bronchial fistula 28.54 12.46 8 190305 32 90438102
Nervous system disorder 28.52 12.46 105 190208 21488 90416646
Paraneoplastic dermatomyositis 28.47 12.46 11 190302 138 90437996
Breast conserving surgery 28.44 12.46 22 190291 1163 90436971
Immune-mediated neurological disorder 28.34 12.46 8 190305 33 90438101
Pustular psoriasis 28.28 12.46 3 190310 18553 90419581
Thrombotic thrombocytopenic purpura 28.25 12.46 39 190274 4099 90434035
Metastases to abdominal cavity 28.24 12.46 17 190296 593 90437541
Gallbladder disorder 28.22 12.46 4 190309 19799 90418335
Toxicity to various agents 28.10 12.46 430 189883 287416 90150718
Obstructive shock 28.05 12.46 9 190304 62 90438072
Acquired amegakaryocytic thrombocytopenia 27.96 12.46 8 190305 35 90438099
Nephrotic syndrome 27.88 12.46 53 190260 7286 90430848
Laboratory test abnormal 27.87 12.46 28 190285 41826 90396308
Endocarditis 27.81 12.46 52 190261 7061 90431073
Bradycardia 27.76 12.46 87 190226 83760 90354374
Seasonal allergy 27.75 12.46 7 190306 22976 90415158
Central vision loss 27.69 12.46 9 190304 65 90438069
Haemoglobinaemia 27.65 12.46 10 190303 103 90438031
Escherichia test positive 27.62 12.46 31 190282 2639 90435495
Myositis 27.52 12.46 112 190201 24016 90414118
Kidney infection 27.49 12.46 10 190303 25906 90412228
Nervousness 27.34 12.46 19 190294 34037 90404097
Tumour marker increased 27.27 12.46 46 190267 5761 90432373
Upper limb fracture 27.19 12.46 6 190307 21572 90416562
Meningitis 27.12 12.46 57 190256 8424 90429710
Transfusion-associated dyspnoea 27.09 12.46 8 190305 40 90438094
Acute polyneuropathy 27.08 12.46 15 190298 446 90437688
Metastases to the mediastinum 27.07 12.46 17 190296 640 90437494
Drug tolerance 27.04 12.46 3 190310 17913 90420221
Bacterial tracheitis 27.03 12.46 7 190306 19 90438115
Adenocarcinoma metastatic 26.99 12.46 12 190301 219 90437915
Pulmonary haemorrhage 26.97 12.46 55 190258 7958 90430176
Paraneoplastic syndrome 26.91 12.46 17 190296 647 90437487
Double hit lymphoma 26.86 12.46 6 190307 6 90438128
Autoimmune hepatitis 26.85 12.46 64 190249 10287 90427847
Tendonitis 26.81 12.46 6 190307 21366 90416768
Fungal infection 26.78 12.46 30 190283 42631 90395503
Herpes zoster 26.77 12.46 105 190208 94539 90343595
Hormone receptor positive breast cancer 26.76 12.46 18 190295 763 90437371
Radiation necrosis 26.70 12.46 17 190296 656 90437478
Blood pressure increased 26.60 12.46 275 190038 196942 90241192
Oligoastrocytoma 26.52 12.46 7 190306 21 90438113
Gastroenteritis radiation 26.50 12.46 16 190297 561 90437573
Blood phosphorus abnormal 26.28 12.46 11 190302 172 90437962
Rhinorrhoea 26.26 12.46 96 190217 88220 90349914
Emotional distress 26.21 12.46 23 190290 36639 90401495
Blood lactate dehydrogenase increased 26.19 12.46 116 190197 25816 90412318
Hyperaemia 26.18 12.46 30 190283 2612 90435522
Gastrointestinal necrosis 26.04 12.46 33 190280 3192 90434942
Gene mutation 26.02 12.46 27 190286 2103 90436031
Dysstasia 26.01 12.46 10 190303 25042 90413092
Mental disorder 25.98 12.46 18 190295 32300 90405834
Pseudocirrhosis 25.93 12.46 19 190294 925 90437209
Joint effusion 25.83 12.46 5 190308 19705 90418429
Loss of consciousness 25.81 12.46 426 189887 139812 90298322
Foetal death 25.63 12.46 6 190307 20717 90417417
Diarrhoea haemorrhagic 25.61 12.46 64 190249 10599 90427535
Scleroedema 25.56 12.46 10 190303 130 90438004
Oesophageal candidiasis 25.55 12.46 49 190264 6780 90431354
Syncope 25.54 12.46 406 189907 132257 90305877
Bone marrow infiltration 25.54 12.46 18 190295 824 90437310
Duodenal perforation 25.51 12.46 20 190293 1078 90437056
Hair colour changes 25.48 12.46 34 190279 3460 90434674
Metastases to bone marrow 25.47 12.46 16 190297 603 90437531
Haemoglobin 25.34 12.46 11 190302 189 90437945
Autoimmune myocarditis 25.28 12.46 12 190301 256 90437878
Morphoea 25.28 12.46 14 190299 416 90437718
Ileal perforation 25.18 12.46 15 190298 513 90437621
Product administration error 25.12 12.46 12 190301 26411 90411723
Encephalitis autoimmune 24.98 12.46 26 190287 2032 90436102
Full blood count abnormal 24.93 12.46 24 190289 36573 90401561
Shock symptom 24.74 12.46 12 190301 269 90437865
Wrong technique in product usage process 24.59 12.46 73 190240 71498 90366636
Adrenal disorder 24.54 12.46 25 190288 1905 90436229
Scintillating scotoma 24.51 12.46 10 190303 146 90437988
Hepatitis cholestatic 24.48 12.46 55 190258 8506 90429628
Fixed bowel loop 24.44 12.46 6 190307 12 90438122
Pulmonary radiation injury 24.44 12.46 6 190307 12 90438122
Bacteraemia 24.24 12.46 102 190211 22198 90415936
Aorto-oesophageal fistula 24.04 12.46 7 190306 33 90438101
Failure to thrive 24.01 12.46 54 190259 8357 90429777
Medulloblastoma recurrent 23.96 12.46 9 190304 104 90438030
Extrapyramidal disorder 23.93 12.46 3 190310 16300 90421834
Aortic wall hypertrophy 23.87 12.46 7 190306 34 90438100
Tumour invasion 23.70 12.46 12 190301 296 90437838
Roseolovirus test positive 23.65 12.46 9 190304 108 90438026
Eye pruritus 23.56 12.46 16 190297 29011 90409123
Hyperlipasaemia 23.45 12.46 17 190296 814 90437320
Escherichia infection 23.31 12.46 80 190233 15815 90422319
Hallucination, auditory 23.31 12.46 3 190310 15972 90422162
Lactic acidosis 23.31 12.46 44 190269 50419 90387715
Adenocarcinoma 23.15 12.46 31 190282 3165 90434969
Hydrocephalus 23.14 12.46 44 190269 6050 90432084
Purpura 23.11 12.46 76 190237 14702 90423432
High grade B-cell lymphoma Burkitt-like lymphoma recurrent 23.07 12.46 8 190305 72 90438062
Peritoneal neoplasm 23.07 12.46 8 190305 72 90438062
Orbital myositis 23.07 12.46 8 190305 72 90438062
Superior vena cava syndrome 23.00 12.46 16 190297 717 90437417
Growth hormone deficiency 22.97 12.46 10 190303 173 90437961
Cachexia 22.90 12.46 47 190266 6831 90431303
Clostridium bacteraemia 22.82 12.46 11 190302 243 90437891
Affect lability 22.80 12.46 5 190308 18058 90420076
Hypoglycaemia 22.75 12.46 73 190240 69775 90368359
Product substitution issue 22.70 12.46 5 190308 18003 90420131
Wrist fracture 22.64 12.46 3 190310 15621 90422513
Metastases to pancreas 22.61 12.46 12 190301 327 90437807
Accidental overdose 22.40 12.46 16 190297 28257 90409877
Pulmonary alveolar haemorrhage 22.40 12.46 43 190270 5955 90432179
Cholelithiasis 22.35 12.46 48 190265 52458 90385676
Cellulitis orbital 22.32 12.46 15 190298 635 90437499
Neonatal respiratory depression 22.32 12.46 10 190303 186 90437948
Bronchopleural fistula 22.30 12.46 11 190302 256 90437878
Oesophagobronchial fistula 22.23 12.46 7 190306 45 90438089
Tumour cavitation 22.23 12.46 7 190306 45 90438089
Swollen tongue 22.18 12.46 39 190274 45917 90392217
Immune-mediated uveitis 22.15 12.46 9 190304 130 90438004
Gastrointestinal fistula 22.11 12.46 14 190299 535 90437599
Endocrine toxicity 22.10 12.46 7 190306 46 90438088
Gastropleural fistula 21.97 12.46 7 190306 47 90438087
Adrenalitis 21.97 12.46 7 190306 47 90438087
Metastases to chest wall 21.89 12.46 15 190298 656 90437478
Asphyxia 21.86 12.46 47 190266 7056 90431078
Vaginal perforation 21.81 12.46 6 190307 22 90438112
Device issue 21.76 12.46 18 190295 29519 90408615
Catheter site thrombosis 21.71 12.46 13 190300 449 90437685
Heavy menstrual bleeding 21.64 12.46 8 190305 20522 90417612
Normal newborn 21.62 12.46 11 190302 23351 90414783
Adrenocortical insufficiency acute 21.61 12.46 27 190286 2574 90435560
Paratracheal lymphadenopathy 21.60 12.46 7 190306 50 90438084
Haemolytic uraemic syndrome 21.49 12.46 28 190285 2783 90435351
Metastases to spinal cord 21.41 12.46 11 190302 280 90437854
Microangiopathic haemolytic anaemia 21.41 12.46 16 190297 803 90437331
Plantar erythema 21.34 12.46 10 190303 207 90437927
Acoustic stimulation tests abnormal 21.33 12.46 8 190305 92 90438042
Escherichia bacteraemia 21.27 12.46 41 190272 5694 90432440
Dyspnoea at rest 21.25 12.46 37 190276 4754 90433380
Venous thrombosis limb 21.23 12.46 31 190282 3431 90434703
Chronic kidney disease 21.22 12.46 179 190134 50012 90388122
Limb injury 21.07 12.46 21 190292 31487 90406647
Acute myelomonocytic leukaemia 21.04 12.46 10 190303 214 90437920
Sneezing 21.04 12.46 19 190294 29850 90408284
Infectious pleural effusion 21.03 12.46 23 190290 1902 90436232
Crying 21.00 12.46 14 190299 25631 90412503
Respiratory disorder 20.93 12.46 68 190245 64748 90373386
Wound dehiscence 20.84 12.46 41 190272 5781 90432353
Autoimmune dermatitis 20.82 12.46 9 190304 153 90437981
Splenic artery thrombosis 20.81 12.46 7 190306 57 90438077
Lip oedema 20.80 12.46 36 190277 4603 90433531
Dry eye 20.70 12.46 58 190255 57873 90380261
Heat cramps 20.67 12.46 4 190309 0 90438134
Gas gangrene 20.66 12.46 9 190304 156 90437978
Temperature regulation disorder 20.65 12.46 3 190310 14576 90423558
Myxoedema 20.61 12.46 9 190304 157 90437977
Gastritis haemorrhagic 20.53 12.46 22 190291 1778 90436356
Thymus enlargement 20.51 12.46 9 190304 159 90437975
Carcinoembryonic antigen increased 20.50 12.46 25 190288 2325 90435809
Circulatory collapse 20.49 12.46 105 190208 24799 90413335
Hypovolaemia 20.41 12.46 65 190248 12366 90425768
Tracheal fistula 20.39 12.46 7 190306 61 90438073
TP53 gene mutation 20.39 12.46 7 190306 61 90438073
Diabetes mellitus 20.31 12.46 69 190244 64806 90373328
Skin laceration 20.28 12.46 15 190298 26020 90412114
Periarticular thenar erythema with onycholysis 20.19 12.46 7 190306 63 90438071
Spinal cord paralysis 20.16 12.46 6 190307 31 90438103
Epiglottic oedema 20.15 12.46 9 190304 166 90437968
Osteonecrosis of jaw 20.15 12.46 146 190167 38957 90399177
Central venous catheterisation 20.14 12.46 27 190286 2759 90435375
Glomerular vascular disorder 20.09 12.46 7 190306 64 90438070
Laryngopharyngitis 20.00 12.46 7 190306 65 90438069
Lymphoedema 19.98 12.46 69 190244 13684 90424450
Intestinal ischaemia 19.97 12.46 52 190261 8831 90429303
Acute leukaemia 19.96 12.46 18 190295 1178 90436956
Hip fracture 19.96 12.46 24 190289 33053 90405081
Neutrophil toxic granulation present 19.96 12.46 9 190304 170 90437964
Bladder perforation 19.96 12.46 9 190304 170 90437964
Feeling jittery 19.93 12.46 4 190309 15367 90422767
Immune-mediated neuropathy 19.92 12.46 8 190305 112 90438022
Platelet count abnormal 19.91 12.46 34 190279 4301 90433833
Ocular hyperaemia 19.89 12.46 25 190288 33773 90404361
Bone marrow disorder 19.84 12.46 28 190285 3004 90435130
Nail discolouration 19.84 12.46 29 190284 3213 90434921
Breast cancer 19.83 12.46 53 190260 53708 90384426
Epiglottitis 19.82 12.46 13 190300 528 90437606
Enteritis 19.79 12.46 57 190256 10264 90427870
Pyelonephritis 19.77 12.46 93 190220 21223 90416911
Balance disorder 19.76 12.46 121 190192 96959 90341175
Type 1 lepra reaction 19.75 12.46 5 190308 12 90438122
Pulse absent 19.72 12.46 41 190272 6014 90432120
Acute lymphocytic leukaemia 19.68 12.46 27 190286 2821 90435313
Toxic cardiomyopathy 19.68 12.46 11 190302 333 90437801
Seroma 19.64 12.46 28 190285 3032 90435102
Bone density decreased 19.61 12.46 6 190307 17339 90420795
Impaired work ability 19.60 12.46 8 190305 19318 90418816
Myocardial infarction 19.58 12.46 136 190177 105836 90332298
Glioblastoma multiforme 19.49 12.46 16 190297 922 90437212
Laryngeal discomfort 19.47 12.46 12 190301 437 90437697
Toxic epidermal necrolysis 19.46 12.46 126 190187 32402 90405732
Laryngeal cancer stage III 19.46 12.46 5 190308 13 90438121
Lipoprotein increased 19.46 12.46 5 190308 13 90438121
Hyperlipidaemia 19.46 12.46 12 190301 22904 90415230
Liver disorder 19.40 12.46 162 190151 121107 90317027
Cardiac murmur 19.33 12.46 7 190306 18187 90419947
Catheter site infection 19.26 12.46 39 190274 5615 90432519
Vaginal cuff dehiscence 19.19 12.46 5 190308 14 90438120
Peripheral paralysis 19.18 12.46 8 190305 124 90438010
Immune-mediated cholestasis 19.13 12.46 6 190307 38 90438096
Retinoblastoma 19.03 12.46 7 190306 76 90438058
Solid organ transplant rejection 19 12.46 6 190307 39 90438095
No adverse event 18.86 12.46 76 190237 67906 90370228
Oropharyngeal pain 18.83 12.46 153 190160 115034 90323100
Mood swings 18.78 12.46 10 190303 20692 90417442
Gout 18.76 12.46 6 190307 16853 90421281
Radiation mucositis 18.74 12.46 6 190307 41 90438093
Pulmonary vascular disorder 18.71 12.46 11 190302 367 90437767
Breast tumour excision 18.70 12.46 5 190308 16 90438118
Pulmonary sarcoidosis 18.69 12.46 18 190295 1281 90436853
Ulcer 18.66 12.46 25 190288 32857 90405277
General symptom 18.64 12.46 4 190309 14664 90423470
Respiratory fatigue 18.61 12.46 8 190305 134 90438000
Interleukin-2 receptor increased 18.51 12.46 8 190305 136 90437998
Omentectomy 18.50 12.46 6 190307 43 90438091
Urinary tract infection enterococcal 18.49 12.46 27 190286 2989 90435145
Hypophagia 18.41 12.46 134 190179 35803 90402331
Multiple organ dysfunction syndrome 18.38 12.46 222 190091 68114 90370020
Hallucination, visual 18.38 12.46 13 190300 23079 90415055
Pancreatic failure 18.38 12.46 19 190294 1473 90436661
Viral infection 18.35 12.46 37 190276 41377 90396757
Band sensation 18.30 12.46 17 190296 1156 90436978
Hypothalamo-pituitary disorder 18.11 12.46 23 190290 2229 90435905
Liver function test abnormal 18.10 12.46 51 190262 50794 90387340
Myelitis transverse 18.09 12.46 19 190294 1501 90436633
Intestinal metastasis 18.07 12.46 9 190304 214 90437920
Hepatic lesion 17.99 12.46 38 190275 5635 90432499
Hepatitis acute 17.94 12.46 57 190256 10830 90427304
Confluent and reticulate papillomatosis 17.91 12.46 4 190309 4 90438130
Lymphadenectomy 17.88 12.46 17 190296 1191 90436943
BRAF V600E mutation positive 17.82 12.46 6 190307 49 90438085
Accidental exposure to product 17.81 12.46 39 190274 42327 90395807
Blood test abnormal 17.75 12.46 11 190302 20941 90417193
Rash morbilliform 17.72 12.46 31 190282 3998 90434136
Blood thyroid stimulating hormone decreased 17.69 12.46 38 190275 5702 90432432
Neuromyopathy 17.66 12.46 14 190299 767 90437367
Drug tolerance decreased 17.66 12.46 25 190288 32105 90406029
Subclavian vein thrombosis 17.64 12.46 22 190291 2094 90436040
Retroperitoneal abscess 17.55 12.46 9 190304 228 90437906
Systemic infection 17.55 12.46 34 190279 4741 90433393
Mixed liver injury 17.52 12.46 45 190268 7578 90430556
Blood pressure diastolic increased 17.50 12.46 3 190310 12903 90425231
Ureteric fistula 17.45 12.46 5 190308 22 90438112
Glaucoma 17.44 12.46 11 190302 20744 90417390
Cardiac failure 17.42 12.46 325 189988 109171 90328963
Lung adenocarcinoma 17.33 12.46 37 190276 5528 90432606
Pneumothorax spontaneous 17.33 12.46 15 190298 930 90437204
Swelling face 17.30 12.46 100 190213 81252 90356882
Rib fracture 17.24 12.46 18 190295 26417 90411717
Transplant rejection 17.22 12.46 3 190310 12755 90425379
Dermatitis exfoliative generalised 17.20 12.46 37 190276 5556 90432578
Pharyngitis streptococcal 17.19 12.46 3 190310 12739 90425395
Panic attack 17.14 12.46 18 190295 26347 90411787
Secretion discharge 17.09 12.46 6 190307 15890 90422244
Monocyte count decreased 17.06 12.46 24 190289 2567 90435567
Troponin T increased 17.06 12.46 19 190294 1604 90436530
Peritoneal fibrosis 17.02 12.46 4 190309 6 90438128
Gastric neoplasm 17.00 12.46 10 190303 334 90437800
Radiation injury 16.96 12.46 13 190300 678 90437456
Granulocytopenia 16.90 12.46 40 190273 6401 90431733
Positron emission tomogram abnormal 16.81 12.46 10 190303 341 90437793
Intestinal strangulation 16.81 12.46 7 190306 108 90438026
Thrombocytosis 16.79 12.46 42 190271 6959 90431175
Hair texture abnormal 16.77 12.46 33 190280 4654 90433480
Unmasking of previously unidentified disease 16.76 12.46 18 190295 1458 90436676
Iron deficiency anaemia 16.73 12.46 15 190298 23647 90414487
Ovarian epithelial cancer 16.71 12.46 10 190303 345 90437789
Autoimmune lung disease 16.69 12.46 7 190306 110 90438024
Coma 16.69 12.46 87 190226 72545 90365589
Xeroderma 16.68 12.46 10 190303 346 90437788
Barotrauma 16.67 12.46 8 190305 175 90437959
Duodenal ulcer 16.65 12.46 51 190262 9501 90428633
Aortic dissection rupture 16.64 12.46 4 190309 7 90438127
Onychalgia 16.62 12.46 16 190297 1138 90436996
Ligament sprain 16.59 12.46 5 190308 14594 90423540
Skin cancer 16.55 12.46 4 190309 13515 90424619
Therapeutic response unexpected 16.54 12.46 13 190300 21867 90416267
Tongue fungal infection 16.52 12.46 7 190306 113 90438021
Renal arteriosclerosis 16.51 12.46 8 190305 179 90437955
Oxygen therapy 16.50 12.46 26 190287 3076 90435058
Spinal cord infarction 16.48 12.46 10 190303 354 90437780
Obstructive airways disorder 16.44 12.46 18 190295 25851 90412283
Abdominal lymphadenopathy 16.40 12.46 15 190298 1000 90437134
Myelitis 16.36 12.46 21 190292 2057 90436077
Jaw operation 16.32 12.46 14 190299 857 90437277
Tumour fistulisation 16.32 12.46 5 190308 29 90438105
HTLV-1 test positive 16.29 12.46 4 190309 8 90438126
Application site recall reaction 16.29 12.46 4 190309 8 90438126
Tooth disorder 16.29 12.46 25 190288 31065 90407069
Eating disorder 16.28 12.46 21 190292 28052 90410082
Ovarian cyst 16.26 12.46 8 190305 17310 90420824
Ischaemia 16.26 12.46 35 190278 5260 90432874
Leukonychia 16.24 12.46 6 190307 66 90438068
Ataxia 16.22 12.46 78 190235 17964 90420170
Head discomfort 16.18 12.46 7 190306 16326 90421808
Noninfective conjunctivitis 16.17 12.46 5 190308 30 90438104
Retinal infarction 16.16 12.46 6 190307 67 90438067
Blood thyroid stimulating hormone increased 16.07 12.46 49 190264 9106 90429028
Pseudomembranous colitis 16.03 12.46 29 190284 3839 90434295
Eye swelling 16.01 12.46 23 190290 29363 90408771
Meningitis herpes 15.99 12.46 9 190304 276 90437858
Fanconi syndrome 15.87 12.46 20 190293 1923 90436211
Retroperitoneal lymphadenopathy 15.86 12.46 13 190300 747 90437387
Skin ulcer 15.85 12.46 53 190260 50022 90388112
Dementia 15.84 12.46 16 190297 23845 90414289
Clostridial infection 15.82 12.46 32 190281 4604 90433530
Enterocutaneous fistula 15.81 12.46 18 190295 1556 90436578
Coating in mouth 15.81 12.46 8 190305 197 90437937
Upper-airway cough syndrome 15.78 12.46 6 190307 15129 90423005
Rhabdomyolysis 15.71 12.46 55 190258 51201 90386933
Lichen planus 15.70 12.46 24 190289 2767 90435367
Hepatic cyst infection 15.68 12.46 7 190306 129 90438005
Intestinal prolapse 15.68 12.46 7 190306 129 90438005
Acute pulmonary oedema 15.64 12.46 50 190263 9530 90428604
Eye excision 15.64 12.46 5 190308 34 90438100
Photophobia 15.62 12.46 13 190300 21256 90416878
Fracture 15.60 12.46 14 190299 22062 90416072
Malignant peritoneal neoplasm 15.60 12.46 13 190300 765 90437369
Arterial thrombosis 15.57 12.46 18 190295 1582 90436552
Renal tubular injury 15.56 12.46 16 190297 1233 90436901
Retinal toxicity 15.55 12.46 17 190296 1405 90436729
Polymicrogyria 15.55 12.46 6 190307 75 90438059
Movement disorder 15.53 12.46 23 190290 28996 90409138
Ankle fracture 15.53 12.46 12 190301 20358 90417776
Ventricular dysfunction 15.50 12.46 28 190285 3703 90434431
Rotator cuff syndrome 15.49 12.46 7 190306 15912 90422222
Rash scarlatiniform 15.48 12.46 8 190305 206 90437928
Cortisol abnormal 15.48 12.46 6 190307 76 90438058
Bronchogram abnormal 15.41 12.46 4 190309 11 90438123
Pelvic venous thrombosis 15.41 12.46 20 190293 1981 90436153
Upper gastrointestinal perforation 15.40 12.46 5 190308 36 90438098
Drug eruption 15.35 12.46 127 190186 35280 90402854
Endometrial cancer metastatic 15.34 12.46 7 190306 136 90437998
Thinking abnormal 15.32 12.46 3 190310 11729 90426405
Suffocation feeling 15.32 12.46 18 190295 1610 90436524
Mesenteric neoplasm 15.28 12.46 5 190308 37 90438097
Blood chloride decreased 15.25 12.46 38 190275 6281 90431853
Aspartate aminotransferase abnormal 15.21 12.46 23 190290 2626 90435508
Ovarian failure 15.19 12.46 18 190295 1625 90436509
Adenosquamous cell lung cancer stage IV 15.15 12.46 4 190309 12 90438122
Anaplastic lymphoma kinase gene mutation 15.15 12.46 4 190309 12 90438122
Type III immune complex mediated reaction 15.10 12.46 10 190303 413 90437721
Mediastinum neoplasm 15.07 12.46 6 190307 82 90438052
Right ventricular failure 15.04 12.46 11 190302 19194 90418940
Neutrophil count 14.99 12.46 10 190303 418 90437716
Oesophageal stenosis 14.94 12.46 28 190285 3808 90434326
Respiratory depression 14.92 12.46 7 190306 15568 90422566
Small intestinal haemorrhage 14.90 12.46 21 190292 2250 90435884
Glycosylated haemoglobin increased 14.90 12.46 7 190306 15555 90422579
Blood glucose increased 14.89 12.46 128 190185 95118 90343016
Osteosarcoma 14.89 12.46 7 190306 146 90437988
Pyomyositis 14.89 12.46 10 190303 423 90437711
Acne 14.87 12.46 23 190290 28484 90409650
Therapy cessation 14.85 12.46 34 190279 36327 90401807
Hepatocellular injury 14.85 12.46 108 190205 28850 90409284
Vesical fistula 14.80 12.46 7 190306 148 90437986
General physical condition abnormal 14.80 12.46 33 190280 5078 90433056
Infusion site reaction 14.79 12.46 11 190302 19028 90419106
Klebsiella test positive 14.78 12.46 17 190296 1486 90436648
Premature menopause 14.73 12.46 16 190297 1313 90436821
Necrotising fasciitis 14.71 12.46 28 190285 3852 90434282
Empyema 14.69 12.46 21 190292 2279 90435855
IIIrd nerve disorder 14.69 12.46 4 190309 14 90438120
Metastases to spleen 14.68 12.46 8 190305 230 90437904
Refractory anaemia with an excess of blasts 14.68 12.46 10 190303 433 90437701
Aortic embolus 14.62 12.46 5 190308 43 90438091
Fluid intake reduced 14.57 12.46 29 190284 4123 90434011
Meningitis aseptic 14.56 12.46 39 190274 6734 90431400
Surgery 14.56 12.46 47 190266 44840 90393294
Non-small cell lung cancer stage IV 14.55 12.46 7 190306 154 90437980
Coordination abnormal 14.55 12.46 14 190299 21342 90416792
Clostridial sepsis 14.55 12.46 11 190302 562 90437572
Hepatic cancer metastatic 14.52 12.46 10 190303 441 90437693
Systemic inflammatory response syndrome 14.50 12.46 38 190275 6478 90431656
Type IV hypersensitivity reaction 14.48 12.46 28 190285 3898 90434236
Radiation proctitis 14.47 12.46 4 190309 15 90438119
Abnormal dreams 14.45 12.46 3 190310 11254 90426880
Autoimmune pericarditis 14.44 12.46 6 190307 92 90438042
Thyroxine free increased 14.34 12.46 14 190299 1013 90437121
Pelvic fracture 14.33 12.46 7 190306 15212 90422922
Sputum discoloured 14.33 12.46 13 190300 20378 90417756
Oxygen saturation 14.32 12.46 8 190305 242 90437892
Eczema asteatotic 14.31 12.46 9 190304 340 90437794
Cardiac disorder 14.29 12.46 66 190247 56806 90381328
Hepatitis toxic 14.27 12.46 27 190286 3698 90434436
Pharyngitis 14.25 12.46 15 190298 21932 90416202
Candida test positive 14.21 12.46 14 190299 1025 90437109
Tumour rupture 14.17 12.46 8 190305 247 90437887
Oropharyngeal discomfort 14.15 12.46 42 190271 7693 90430441
Meibomianitis 14.14 12.46 5 190308 48 90438086
Urge incontinence 14.08 12.46 15 190298 1204 90436930
Abdominal infection 14.08 12.46 21 190292 2369 90435765
Chromosomal mutation 14.08 12.46 4 190309 17 90438117
Metastases to vagina 14.08 12.46 4 190309 17 90438117
Escherichia sepsis 14.06 12.46 35 190278 5781 90432353
Epilepsy 13.99 12.46 108 190205 82098 90356036
Agitation 13.99 12.46 83 190230 67015 90371119
Oral herpes 13.98 12.46 31 190282 33493 90404641
Rhinitis allergic 13.96 12.46 9 190304 16776 90421358
Metastatic uterine cancer 13.96 12.46 7 190306 169 90437965
Peritoneal lesion 13.89 12.46 4 190309 18 90438116
Autoimmune pancreatitis 13.89 12.46 9 190304 358 90437776
Pulmonary hilar enlargement 13.88 12.46 6 190307 102 90438032
Sensorimotor disorder 13.87 12.46 12 190301 743 90437391
Bacterial translocation 13.86 12.46 12 190301 744 90437390
Blood culture positive 13.86 12.46 32 190281 5040 90433094
Cardiomyopathy 13.81 12.46 81 190232 20125 90418009
Metastases to retroperitoneum 13.74 12.46 7 190306 175 90437959
Blood alkaline phosphatase increased 13.73 12.46 158 190155 47921 90390213
Uterine adhesions 13.70 12.46 5 190308 53 90438081
International normalised ratio increased 13.70 12.46 52 190261 47264 90390870
Pneumonia moraxella 13.70 12.46 5 190308 53 90438081
Papillitis 13.70 12.46 5 190308 53 90438081
Hypersomnia 13.67 12.46 15 190298 21516 90416618
Staphylococcus test positive 13.66 12.46 29 190284 4316 90433818
Paranoia 13.66 12.46 5 190308 12903 90425231
Eustachian tube dysfunction 13.64 12.46 12 190301 760 90437374
Streptococcus test positive 13.64 12.46 16 190297 1429 90436705
Cyst 13.61 12.46 9 190304 16552 90421582
Idiopathic interstitial pneumonia 13.61 12.46 8 190305 267 90437867
Infusion site thrombosis 13.59 12.46 7 190306 179 90437955
Lung cancer metastatic 13.59 12.46 23 190290 2888 90435246
Peripheral sensorimotor neuropathy 13.55 12.46 19 190294 2026 90436108
Skin disorder 13.50 12.46 127 190186 36579 90401555
Paraesthesia 13.49 12.46 649 189664 249677 90188457
Psychomotor hyperactivity 13.49 12.46 5 190308 12808 90425326
Abdominal distension 13.46 12.46 193 190120 130408 90307726
Ovarian epithelial cancer metastatic 13.43 12.46 3 190310 3 90438131
Subclavian vein stenosis 13.43 12.46 3 190310 3 90438131
Kernicterus 13.43 12.46 3 190310 3 90438131
Increased appetite 13.42 12.46 4 190309 11761 90426373
Metastases to thorax 13.42 12.46 8 190305 274 90437860
Large intestinal obstruction 13.42 12.46 22 190291 2692 90435442
Areflexia 13.41 12.46 26 190287 3627 90434507
Blood urine present 13.40 12.46 10 190303 17268 90420866
Intervertebral disc degeneration 13.39 12.46 10 190303 17264 90420870
Pneumoretroperitoneum 13.39 12.46 4 190309 21 90438113
Anhidrosis 13.38 12.46 7 190306 185 90437949
Lymphorrhoea 13.37 12.46 5 190308 57 90438077
Lymphangioleiomyomatosis 13.37 12.46 8 190305 276 90437858
Small cell carcinoma 13.35 12.46 7 190306 186 90437948
Infusion site swelling 13.35 12.46 4 190309 11716 90426418
Coombs negative haemolytic anaemia 13.33 12.46 9 190304 384 90437750
Angiodermatitis 13.28 12.46 7 190306 188 90437946
Reactive gastropathy 13.26 12.46 11 190302 643 90437491
Anisocytosis 13.26 12.46 12 190301 789 90437345
Ovarian cancer stage IV 13.24 12.46 8 190305 281 90437853
Anal haemorrhage 13.21 12.46 21 190292 2503 90435631
Mood altered 13.19 12.46 10 190303 17134 90421000
Oophorectomy bilateral 13.18 12.46 6 190307 116 90438018
Protein urine 13.12 12.46 12 190301 800 90437334
Trichiasis 13.04 12.46 6 190307 119 90438015
Injection site induration 13.01 12.46 3 190310 10465 90427669
Lividity 13.00 12.46 9 190304 400 90437734
Skin oedema 12.98 12.46 14 190299 1140 90436994
Pneumonectomy 12.97 12.46 3 190310 4 90438130
Flatulence 12.94 12.46 44 190269 41323 90396811
Sideroblastic anaemia 12.94 12.46 4 190309 24 90438110
Breast necrosis 12.92 12.46 7 190306 199 90437935
Musculoskeletal disorder 12.92 12.46 16 190297 21753 90416381
Metastases to soft tissue 12.89 12.46 8 190305 295 90437839
Dysuria 12.88 12.46 133 190180 39268 90398866
IIIrd nerve paralysis 12.87 12.46 12 190301 820 90437314
Caesarean section 12.87 12.46 12 190301 18565 90419569
Epiphyses premature fusion 12.85 12.46 5 190308 64 90438070
Metastases to eye 12.83 12.46 7 190306 202 90437932
Poor quality sleep 12.80 12.46 20 190293 24673 90413461
Liver sarcoidosis 12.80 12.46 4 190309 25 90438109
CSF volume increased 12.80 12.46 4 190309 25 90438109
Rectal tenesmus 12.80 12.46 14 190299 1158 90436976
Uterine fistula 12.80 12.46 4 190309 25 90438109
Clonal haematopoiesis 12.80 12.46 4 190309 25 90438109
Muscle oedema 12.80 12.46 4 190309 25 90438109
Cell death 12.78 12.46 23 190290 3032 90435102
Autoimmune thyroiditis 12.74 12.46 34 190279 5859 90432275
Cardiac tamponade 12.69 12.46 33 190280 5599 90432535
Bronchiectasis 12.65 12.46 17 190296 22313 90415821
Gastrointestinal mucosal disorder 12.64 12.46 12 190301 839 90437295
Foetal exposure during pregnancy 12.59 12.46 47 190266 42928 90395206
Congestive cardiomyopathy 12.58 12.46 39 190274 7315 90430819
Gastrointestinal candidiasis 12.56 12.46 8 190305 309 90437825
Incarcerated incisional hernia 12.54 12.46 4 190309 27 90438107
Emotional disorder 12.53 12.46 8 190305 14989 90423145
Portal venous gas 12.51 12.46 5 190308 69 90438065
Atelectasis 12.50 12.46 91 190222 24318 90413816
Mycobacterium avium complex infection 12.48 12.46 27 190286 4071 90434063
Cardiac dysfunction 12.48 12.46 25 190288 3572 90434562

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Malignant neoplasm progression 1813.62 13.24 1883 121601 106517 42391334
Disease progression 1613.60 13.24 2030 121454 141626 42356225
Febrile neutropenia 1602.34 13.24 2307 121177 183396 42314455
Neutropenia 1181.65 13.24 2088 121396 197343 42300508
Pancytopenia 1122.13 13.24 1536 121948 116207 42381644
Thrombocytopenia 998.48 13.24 1891 121593 188388 42309463
Myelosuppression 997.38 13.24 872 122612 39589 42458262
Therapy partial responder 705.89 13.24 532 122952 19489 42478362
Anaemia 667.65 13.24 2051 121433 278227 42219624
Interstitial lung disease 653.89 13.24 961 122523 77501 42420350
Neutrophil count decreased 622.23 13.24 840 122644 62575 42435276
Mucosal inflammation 519.60 13.24 677 122807 48697 42449154
Haematotoxicity 511.84 13.24 346 123138 10639 42487212
Neoplasm progression 471.15 13.24 497 122987 28503 42469348
Leukopenia 452.90 13.24 792 122692 73954 42423897
Pneumonitis 400.44 13.24 547 122937 41171 42456680
Product dose omission issue 356.71 13.24 23 123461 154342 42343509
Immune-mediated enterocolitis 349.12 13.24 213 123271 5464 42492387
Immune-mediated lung disease 337.83 13.24 176 123308 3297 42494554
Bone marrow failure 337.53 13.24 447 123037 32646 42465205
Metastases to central nervous system 336.00 13.24 262 123222 10093 42487758
Radiation pneumonitis 324.14 13.24 162 123322 2771 42495080
Neutropenic sepsis 317.11 13.24 305 123179 15641 42482210
Off label use 289.54 13.24 2966 120518 635369 41862482
Drug abuse 287.06 13.24 3 123481 104768 42393083
Febrile bone marrow aplasia 286.53 13.24 237 123247 9944 42487907
Fall 260.04 13.24 181 123303 234339 42263512
Completed suicide 258.80 13.24 4 123480 96461 42401390
Colitis 245.71 13.24 465 123019 46107 42451744
Pulmonary toxicity 236.34 13.24 198 123286 8457 42489394
Immune-mediated hepatic disorder 232.00 13.24 123 123361 2391 42495460
Septic shock 229.36 13.24 684 122800 90988 42406863
Overdose 201.13 13.24 32 123452 105232 42392619
Skin toxicity 198.06 13.24 159 123325 6390 42491461
Headache 185.17 13.24 254 123230 239115 42258736
Platelet count decreased 180.88 13.24 838 122646 137743 42360108
Cytopenia 177.81 13.24 236 123248 17261 42480590
Nasopharyngitis 168.68 13.24 22 123462 83974 42413877
Drug interaction 164.09 13.24 329 123155 266670 42231181
Anxiety 160.87 13.24 71 123413 118489 42379362
Immune-mediated hepatitis 159.56 13.24 112 123372 3662 42494189
White blood cell count decreased 158.61 13.24 687 122797 109709 42388142
Non-small cell lung cancer 155.20 13.24 123 123361 4851 42493000
Depression 153.77 13.24 65 123419 111298 42386553
Hypothyroidism 149.35 13.24 304 123180 31780 42466071
Metastases to bone 146.27 13.24 197 123287 14612 42483239
Weight increased 144.40 13.24 66 123418 107917 42389934
Haemoptysis 142.50 13.24 372 123112 45795 42452056
Sepsis 141.39 13.24 1025 122459 198309 42299542
Intentional product misuse 140.59 13.24 10 123474 61890 42435961
Injection site pain 138.34 13.24 7 123477 57791 42440060
Immune-mediated dermatitis 137.42 13.24 69 123415 1192 42496659
Peripheral swelling 134.05 13.24 47 123437 90223 42407628
Product use in unapproved indication 133.97 13.24 954 122530 183502 42314349
Oesophagitis 132.91 13.24 191 123293 15056 42482795
Hyperthyroidism 131.43 13.24 184 123300 14157 42483694
Renal salt-wasting syndrome 130.07 13.24 48 123436 368 42497483
Radiation oesophagitis 129.71 13.24 50 123434 438 42497413
Diffuse large B-cell lymphoma recurrent 127.69 13.24 109 123375 4777 42493074
Adrenal insufficiency 125.60 13.24 209 123275 18715 42479136
Decreased appetite 125.55 13.24 973 122511 192164 42305687
Joint swelling 124.79 13.24 23 123461 67999 42429852
Metastases to meninges 121.65 13.24 74 123410 1887 42495964
Immune-mediated hypothyroidism 119.45 13.24 63 123421 1211 42496640
Tremor 119.44 13.24 66 123418 96863 42400988
Bradycardia 119.43 13.24 49 123435 85435 42412416
Blood pressure increased 119.10 13.24 74 123410 101854 42395997
Hospitalisation 118.72 13.24 34 123450 74296 42423555
Toxicity to various agents 116.03 13.24 313 123171 228823 42269028
Abdominal discomfort 115.54 13.24 37 123447 75218 42422633
Pyrexia 113.82 13.24 1685 121799 392357 42105494
Feeling abnormal 113.17 13.24 31 123453 69755 42428096
Insomnia 112.48 13.24 106 123378 118147 42379704
Arthralgia 111.89 13.24 270 123214 204968 42292883
Somnolence 111.74 13.24 147 123337 140958 42356893
Suicidal ideation 111.66 13.24 7 123477 48154 42449697
Dizziness 111.38 13.24 361 123123 248893 42248958
Loss of personal independence in daily activities 110.43 13.24 9 123475 49807 42448044
Stress 110.29 13.24 4 123480 44208 42453643
Adrenocorticotropic hormone deficiency 109.65 13.24 61 123423 1309 42496542
Musculoskeletal stiffness 109.31 13.24 18 123466 57747 42440104
General physical health deterioration 109.02 13.24 781 122703 150465 42347386
Suicide attempt 109.01 13.24 6 123478 46094 42451757
Cytokine release syndrome 108.18 13.24 329 123155 44198 42453653
Tumour lysis syndrome 107.46 13.24 214 123270 22017 42475834
Plasma cell myeloma 107.14 13.24 8 123476 47570 42450281
Hallucination 104.30 13.24 20 123464 57487 42440364
Asthma 104.25 13.24 26 123458 62288 42435563
Pain in extremity 102.65 13.24 174 123310 150430 42347421
Gastrointestinal toxicity 100.39 13.24 87 123397 3892 42493959
Metastases to liver 98.71 13.24 173 123311 16153 42481698
Second primary malignancy 98.58 13.24 130 123354 9445 42488406
Bicytopenia 97.76 13.24 78 123406 3106 42494745
Electrocardiogram QT prolonged 97.59 13.24 12 123472 47933 42449918
Neuropathy peripheral 97.38 13.24 565 122919 101288 42396563
Aplasia 96.95 13.24 93 123391 4750 42493101
Immune-mediated myocarditis 96.48 13.24 66 123418 2068 42495783
Hypopituitarism 95.73 13.24 73 123411 2718 42495133
Lichenoid keratosis 94.91 13.24 84 123400 3866 42493985
Nephritis 93.89 13.24 82 123402 3707 42494144
Stomatitis 93.81 13.24 340 123144 49989 42447862
Metastases to lung 93.61 13.24 139 123345 11285 42486566
Acute myeloid leukaemia 92.08 13.24 201 123283 22055 42475796
Tubulointerstitial nephritis 92.05 13.24 249 123235 31299 42466552
Muscle spasms 91.79 13.24 69 123415 85975 42411876
Cardiac failure congestive 90.86 13.24 69 123415 85533 42412318
Cardiac disorder 88.77 13.24 17 123467 48915 42448936
Pain 87.69 13.24 388 123096 244460 42253391
Eastern Cooperative Oncology Group performance status worsened 86.97 13.24 52 123432 1284 42496567
Hypertransaminasaemia 86.96 13.24 120 123364 9107 42488744
Immune-mediated adrenal insuficiency 84.62 13.24 42 123442 707 42497144
Pseudocellulitis 82.43 13.24 31 123453 252 42497599
Hepatic cytolysis 80.45 13.24 214 123270 26630 42471221
Gait disturbance 79.71 13.24 100 123384 97900 42399951
Myelodysplastic syndrome 79.29 13.24 192 123292 22553 42475298
Drug hypersensitivity 78.18 13.24 104 123380 99285 42398566
Hypomagnesaemia 77.32 13.24 219 123265 28269 42469582
Myocarditis 77.17 13.24 170 123314 18768 42479083
Sleep disorder 76.79 13.24 22 123462 48073 42449778
Tumour pseudoprogression 76.60 13.24 44 123440 1006 42496845
Pneumothorax 76.01 13.24 193 123291 23350 42474501
Drug reaction with eosinophilia and systemic symptoms 75.52 13.24 15 123469 42060 42455791
Memory impairment 74.79 13.24 26 123458 50196 42447655
Heart rate decreased 74.70 13.24 9 123475 36523 42461328
Incorrect dose administered 74.57 13.24 30 123454 52944 42444907
Rhabdomyolysis 74.08 13.24 70 123414 77949 42419902
Hypertension 74.02 13.24 243 123241 166961 42330890
Lactic acidosis 73.57 13.24 20 123464 45241 42452610
Myocardial infarction 73.31 13.24 156 123328 123853 42373998
Therapeutic product effect decreased 72.31 13.24 13 123471 39137 42458714
Neutropenic colitis 71.46 13.24 76 123408 4394 42493457
Aggression 70.88 13.24 20 123464 44143 42453708
Inappropriate schedule of product administration 70.79 13.24 105 123379 95797 42402054
Diffuse large B-cell lymphoma refractory 70.18 13.24 53 123431 1944 42495907
Neoplasm recurrence 69.61 13.24 60 123424 2664 42495187
Bronchial fistula 69.07 13.24 26 123458 212 42497639
Cardiotoxicity 68.93 13.24 96 123388 7349 42490502
Dehydration 68.86 13.24 670 122814 141097 42356754
Influenza 67.41 13.24 49 123435 62126 42435725
Disturbance in attention 67.30 13.24 5 123479 29861 42467990
Immune-mediated encephalitis 66.41 13.24 34 123450 613 42497238
Nephrolithiasis 66.37 13.24 13 123471 36817 42461034
Hypophysitis 66.37 13.24 61 123423 2950 42494901
Encephalitis autoimmune 65.62 13.24 44 123440 1333 42496518
Wrong technique in product usage process 65.36 13.24 21 123463 42614 42455237
Blood cholesterol increased 64.74 13.24 3 123481 26738 42471113
Condition aggravated 64.18 13.24 467 123017 260287 42237564
Hypoglycaemia 63.82 13.24 48 123436 59806 42438045
Arthropathy 63.82 13.24 6 123478 29591 42468260
Sinusitis 63.03 13.24 29 123455 47263 42450588
Blood pressure fluctuation 62.10 13.24 4 123480 26904 42470947
Polyneuropathy 61.31 13.24 154 123330 18507 42479344
Blood glucose increased 61.19 13.24 74 123410 73625 42424226
Immune-mediated renal disorder 60.89 13.24 29 123455 444 42497407
Rash maculo-papular 60.51 13.24 242 123242 37261 42460590
Paraneoplastic neurological syndrome 60.40 13.24 19 123465 83 42497768
Vision blurred 59.96 13.24 41 123443 53658 42444193
Drug dependence 59.90 13.24 7 123477 29087 42468764
Pneumonia 59.89 13.24 1623 121861 420526 42077325
Serotonin syndrome 59.18 13.24 4 123480 25841 42472010
Dysphagia 58.52 13.24 386 123098 72333 42425518
Hypokalaemia 58.51 13.24 382 123102 71339 42426512
Agitation 58.41 13.24 60 123424 64254 42433597
Accidental overdose 57.87 13.24 7 123477 28323 42469528
Upper respiratory tract infection 57.56 13.24 25 123459 42148 42455703
Choroidal infarction 57.53 13.24 18 123466 77 42497774
Abdominal distension 57.49 13.24 74 123410 71661 42426190
Retinal pigment epitheliopathy 57.08 13.24 23 123461 229 42497622
Treatment noncompliance 56.96 13.24 19 123465 37653 42460198
Anaplastic lymphoma kinase gene mutation 56.46 13.24 19 123465 107 42497744
Tracheo-oesophageal fistula 56.44 13.24 29 123455 527 42497324
Gastrooesophageal reflux disease 56.39 13.24 30 123454 44993 42452858
Respiratory failure 56.18 13.24 593 122891 127539 42370312
Ototoxicity 54.98 13.24 49 123435 2276 42495575
Superior vena cava syndrome 54.95 13.24 31 123453 684 42497167
Disease recurrence 54.87 13.24 200 123284 29478 42468373
Agranulocytosis 54.67 13.24 204 123280 30408 42467443
Anaphylactic shock 54.53 13.24 171 123313 23346 42474505
Illness 53.89 13.24 5 123479 24925 42472926
Haematochezia 53.65 13.24 54 123430 58382 42439469
Erythema multiforme 53.04 13.24 100 123384 9877 42487974
Pneumatosis intestinalis 52.80 13.24 67 123417 4685 42493166
Contusion 52.55 13.24 28 123456 41957 42455894
Haemophagocytic lymphohistiocytosis 52.32 13.24 143 123341 18079 42479772
Urticaria 51.82 13.24 84 123400 73952 42423899
Adverse drug reaction 49.82 13.24 23 123461 37411 42460440
Alopecia 49.72 13.24 192 123292 29084 42468767
Renal tubular disorder 49.53 13.24 66 123418 4843 42493008
Flatulence 49.49 13.24 7 123477 25145 42472706
Amnesia 49.26 13.24 11 123473 28426 42469425
Psychotic disorder 49.20 13.24 12 123472 29196 42468655
Psoriatic arthropathy 49.01 13.24 7 123477 24960 42472891
Unevaluable event 48.94 13.24 19 123465 34269 42463582
Cholangitis sclerosing 48.82 13.24 42 123442 1860 42495991
Prostate cancer 48.63 13.24 35 123449 44608 42453243
Pleural effusion 48.51 13.24 462 123022 96704 42401147
Blood lactate dehydrogenase increased 48.42 13.24 176 123308 25905 42471946
Foetal exposure during pregnancy 47.84 13.24 40 123444 47271 42450580
Drug level increased 47.74 13.24 9 123475 26191 42471660
Depressed mood 47.22 13.24 6 123478 23378 42474473
Metastasis 47.08 13.24 63 123421 4642 42493209
Influenza like illness 46.52 13.24 17 123467 31823 42466028
Immune-mediated cholangitis 46.33 13.24 25 123459 504 42497347
Cholangitis 45.65 13.24 98 123386 10629 42487222
Dermatitis 45.47 13.24 104 123380 11771 42486080
Type 1 diabetes mellitus 45.29 13.24 67 123417 5420 42492431
Myositis 45.03 13.24 119 123365 14747 42483104
Mobility decreased 44.99 13.24 23 123461 35283 42462568
Weight decreased 44.82 13.24 386 123098 207562 42290289
Fanconi syndrome 44.80 13.24 39 123445 1755 42496096
Pericarditis malignant 44.72 13.24 14 123470 60 42497791
Coronary artery disease 44.52 13.24 54 123430 53666 42444185
Frequent bowel movements 44.44 13.24 5 123479 21402 42476449
Abnormal behaviour 44.30 13.24 11 123473 26440 42471411
Blood pressure systolic increased 44.26 13.24 13 123471 27955 42469896
Enteritis 43.96 13.24 97 123387 10719 42487132
Performance status decreased 43.90 13.24 61 123423 4659 42493192
Full blood count abnormal 43.57 13.24 16 123468 29860 42467991
Back pain 43.54 13.24 237 123247 141539 42356312
Small intestinal perforation 43.50 13.24 48 123436 2893 42494958
Immune-mediated adverse reaction 43.35 13.24 30 123454 958 42496893
Secondary adrenocortical insufficiency 43.33 13.24 41 123443 2058 42495793
Basal cell carcinoma 43.19 13.24 7 123477 22726 42475125
Immune-mediated hypophysitis 43.15 13.24 22 123462 393 42497458
Medication error 43.15 13.24 21 123463 33133 42464718
Hepatitis 43.11 13.24 175 123309 27125 42470726
Pulmonary radiation injury 42.64 13.24 13 123471 50 42497801
Swelling 42.56 13.24 58 123426 54827 42443024
Thrombophlebitis migrans 42.55 13.24 21 123463 349 42497502
Sleep apnoea syndrome 42.55 13.24 6 123478 21602 42476249
Diabetes mellitus 42.21 13.24 68 123416 60019 42437832
Metastases to lymph nodes 42.16 13.24 68 123416 5930 42491921
Immune-mediated hyperthyroidism 41.93 13.24 18 123466 213 42497638
Hepatic function abnormal 41.64 13.24 274 123210 51293 42446558
Rhinorrhoea 41.59 13.24 20 123464 31774 42466077
Irritability 41.12 13.24 15 123469 28113 42469738
Incorrect route of product administration 40.91 13.24 10 123474 24295 42473556
Road traffic accident 40.82 13.24 4 123480 19089 42478762
Balance disorder 40.44 13.24 47 123437 47598 42450253
Bronchopleural fistula 40.26 13.24 25 123459 662 42497189
Administration site extravasation 39.81 13.24 26 123458 753 42497098
Thrombosis 39.78 13.24 87 123397 68424 42429427
Radiation skin injury 39.62 13.24 26 123458 759 42497092
Peripheral sensory neuropathy 39.55 13.24 82 123402 8680 42489171
Metabolic acidosis 39.01 13.24 56 123428 51802 42446049
Benign prostatic hyperplasia 38.85 13.24 7 123477 21045 42476806
Lung lobectomy 38.81 13.24 13 123471 72 42497779
Gastrointestinal perforation 38.80 13.24 56 123428 4430 42493421
Metastatic neoplasm 38.77 13.24 49 123435 3412 42494439
Cytokine storm 38.51 13.24 27 123457 881 42496970
Cerebrovascular accident 38.42 13.24 148 123336 97012 42400839
Immune thrombocytopenia 38.36 13.24 94 123390 11122 42486729
Pulmonary arteriopathy 38.22 13.24 13 123471 76 42497775
Dyskinesia 38.05 13.24 13 123471 25377 42472474
Non-small cell lung cancer metastatic 37.94 13.24 26 123458 817 42497034
Nasal congestion 37.92 13.24 19 123465 29482 42468369
Oesophagobronchial fistula 37.75 13.24 16 123468 183 42497668
Diarrhoea 37.52 13.24 1662 121822 459187 42038664
Osteoarthritis 37.44 13.24 12 123472 24393 42473458
Therapy cessation 37.31 13.24 7 123477 20443 42477408
Hypercreatininaemia 37.09 13.24 22 123462 535 42497316
Rheumatoid arthritis 36.96 13.24 41 123443 42399 42455452
Surgery 36.86 13.24 4 123480 17612 42480239
Lung adenocarcinoma 36.81 13.24 60 123424 5279 42492572
Extrapyramidal disorder 36.27 13.24 3 123481 16409 42481442
Nausea 36.11 13.24 1448 122036 395351 42102500
Metastases to adrenals 35.99 13.24 28 123456 1074 42496777
Encephalitis 35.95 13.24 81 123403 9077 42488774
Nephropathy toxic 35.92 13.24 119 123365 16719 42481132
Head injury 35.57 13.24 8 123476 20574 42477277
Hiccups 35.43 13.24 96 123388 12075 42485776
International normalised ratio increased 35.27 13.24 53 123431 48115 42449736
Pulmonary vascular disorder 35.25 13.24 23 123461 665 42497186
Palpitations 35.20 13.24 58 123426 50739 42447112
Product quality issue 35.13 13.24 5 123479 17877 42479974
Recall phenomenon 35.05 13.24 22 123462 594 42497257
Intestinal perforation 34.95 13.24 89 123395 10785 42487066
Wheezing 34.84 13.24 66 123418 54715 42443136
Immune-mediated gastritis 34.64 13.24 13 123471 105 42497746
Injection site erythema 34.60 13.24 8 123476 20187 42477664
Viral infection 34.59 13.24 11 123473 22472 42475379
Palmar erythema 34.43 13.24 21 123463 538 42497313
Injury 34.18 13.24 11 123473 22305 42475546
Labelled drug-drug interaction medication error 34.02 13.24 3 123481 15579 42482272
Myasthenic syndrome 33.86 13.24 24 123460 797 42497054
Angioedema 33.84 13.24 44 123440 42433 42455418
Tumour necrosis 33.72 13.24 32 123452 1612 42496239
Coma 33.64 13.24 65 123419 53489 42444362
Portal venous gas 33.62 13.24 20 123464 489 42497362
Mental disorder 33.26 13.24 6 123478 18023 42479828
Peripheral ischaemia 33.24 13.24 64 123420 6421 42491430
Lymphangiosis carcinomatosa 33.12 13.24 26 123458 1011 42496840
Visual impairment 32.98 13.24 46 123438 43067 42454784
Bronchospasm 32.97 13.24 97 123387 12788 42485063
Hallucination, visual 32.84 13.24 10 123474 21010 42476841
B-cell lymphoma recurrent 32.81 13.24 24 123460 838 42497013
Injection site swelling 32.75 13.24 5 123479 16968 42480883
Heart rate irregular 32.70 13.24 4 123480 16046 42481805
Cholestasis 32.43 13.24 184 123300 32695 42465156
Histiocytic necrotising lymphadenitis 32.32 13.24 8 123476 10 42497841
Therapy interrupted 32.30 13.24 12 123472 22238 42475613
Non-small cell lung cancer recurrent 32.24 13.24 11 123473 65 42497786
Lymphadenopathy mediastinal 32.14 13.24 43 123441 3168 42494683
EGFR gene mutation 32.13 13.24 15 123469 219 42497632
Inappropriate antidiuretic hormone secretion 31.87 13.24 113 123371 16428 42481423
Dermatomyositis 31.85 13.24 31 123453 1612 42496239
Autoimmune hepatitis 31.79 13.24 58 123426 5587 42492264
Asthenia 31.68 13.24 1050 122434 279743 42218108
Swollen tongue 31.59 13.24 11 123473 21220 42476631
Acute promyelocytic leukaemia 31.48 13.24 22 123462 714 42497137
Acute kidney injury 31.46 13.24 1332 122152 366005 42131846
Juvenile melanoma benign 31.43 13.24 11 123473 71 42497780
Synovitis 31.42 13.24 4 123480 15563 42482288
Psoriasis 31.40 13.24 58 123426 48546 42449305
Cardiac arrest 31.26 13.24 187 123297 109133 42388718
Extremity necrosis 31.15 13.24 36 123448 2283 42495568
Hepatotoxicity 31.14 13.24 150 123334 25017 42472834
Metastases to spleen 31.04 13.24 19 123465 490 42497361
Wound 30.93 13.24 6 123478 17111 42480740
Tumour haemorrhage 30.86 13.24 45 123439 3593 42494258
Drug intolerance 30.84 13.24 124 123360 80300 42417551
Venoocclusive liver disease 30.73 13.24 82 123402 10220 42487631
Immune-mediated arthritis 30.64 13.24 16 123468 301 42497550
Guillain-Barre syndrome 30.50 13.24 66 123418 7197 42490654
Restlessness 30.48 13.24 24 123460 29225 42468626
Tracheal fistula 30.42 13.24 13 123471 152 42497699
Haemorrhage 30.37 13.24 83 123401 60480 42437371
Thyroiditis 30.36 13.24 42 123442 3194 42494657
Impaired quality of life 30.23 13.24 3 123481 14174 42483677
Immune-mediated cystitis 30.07 13.24 11 123473 82 42497769
Immune-mediated pancreatitis 30.04 13.24 16 123468 314 42497537
Transient ischaemic attack 30.03 13.24 32 123452 33707 42464144
Optic glioma 29.85 13.24 9 123475 33 42497818
Retinopathy proliferative 29.84 13.24 11 123473 84 42497767
Adrenal disorder 29.70 13.24 26 123458 1179 42496672
Metastases to pleura 29.68 13.24 20 123464 611 42497240
Accidental exposure to product 29.60 13.24 11 123473 20382 42477469
Drug resistance 29.50 13.24 185 123299 34063 42463788
Burning sensation 29.40 13.24 12 123472 21001 42476850
Vomiting 29.34 13.24 1070 122414 288653 42209198
Immune-mediated nephritis 29.19 13.24 21 123463 714 42497137
Hypocalcaemia 29.19 13.24 168 123316 30005 42467846
Hyperlipidaemia 28.97 13.24 13 123471 21503 42476348
Autoimmune colitis 28.89 13.24 25 123459 1116 42496735
Dermatitis acneiform 28.77 13.24 67 123417 7672 42490179
Myalgia 28.72 13.24 162 123322 95918 42401933
Body height below normal 28.62 13.24 14 123470 228 42497623
Nervousness 28.50 13.24 3 123481 13529 42484322
Cataract 28.41 13.24 28 123456 30576 42467275
Extraocular muscle disorder 28.35 13.24 14 123470 233 42497618
Emotional distress 28.33 13.24 6 123478 16087 42481764
Pruritus 28.30 13.24 381 123103 188390 42309461
Arthritis 28.25 13.24 49 123435 42016 42455835
Pulmonary oedema 28.24 13.24 71 123413 53201 42444650
Fluid retention 28.13 13.24 30 123454 31589 42466262
Immune-mediated oesophagitis 28.13 13.24 9 123475 42 42497809
Pulmonary sepsis 28.03 13.24 41 123443 3283 42494568
Toxic epidermal necrolysis 27.91 13.24 152 123332 26598 42471253
Blood triglycerides increased 27.83 13.24 6 123478 15890 42481961
Haemolytic uraemic syndrome 27.62 13.24 35 123449 2444 42495407
Obstructive airways disorder 27.50 13.24 19 123465 24740 42473111
Cardiogenic shock 27.29 13.24 38 123446 35602 42462249
Confusional state 27.06 13.24 333 123151 167264 42330587
Depressed level of consciousness 26.96 13.24 62 123422 47908 42449943
Retroperitoneal lymphadenopathy 26.88 13.24 23 123461 1011 42496840
Myoclonus 26.88 13.24 8 123476 17057 42480794
Oropharyngeal squamous cell carcinoma 26.74 13.24 14 123470 265 42497586
Neutropenic infection 26.73 13.24 30 123454 1843 42496008
Pulmonary embolism 26.71 13.24 491 122993 119121 42378730
Lichen planus 26.47 13.24 25 123459 1252 42496599
Immune-mediated thyroiditis 26.35 13.24 17 123467 482 42497369
Eosinophilia 26.28 13.24 34 123450 32865 42464986
Delayed puberty 26.24 13.24 13 123471 218 42497633
Oesophagopleural fistula 26.13 13.24 9 123475 55 42497796
Contraindicated product administered 26.00 13.24 21 123463 25251 42472600
Radiation associated pain 25.99 13.24 8 123476 32 42497819
Iris atrophy 25.90 13.24 10 123474 88 42497763
Adrenocortical insufficiency acute 25.84 13.24 32 123452 2183 42495668
Hepatic steatosis 25.83 13.24 15 123469 21433 42476418
Fungating wound 25.72 13.24 9 123475 58 42497793
Hepatocellular injury 25.69 13.24 136 123348 23542 42474309
Infusion related hypersensitivity reaction 25.61 13.24 13 123471 230 42497621
Radiotherapy 25.60 13.24 21 123463 870 42496981
Dermatitis atopic 25.49 13.24 3 123481 12401 42485450
Gastrointestinal haemorrhage 25.46 13.24 172 123312 97554 42400297
Obesity 25.41 13.24 8 123476 16451 42481400
Jaundice 25.38 13.24 38 123446 34551 42463300
Osteoporosis 25.35 13.24 6 123478 14900 42482951
Joint stiffness 25.27 13.24 3 123481 12319 42485532
Rhabdomyosarcoma recurrent 25.27 13.24 11 123473 135 42497716
Metastases to muscle 25.21 13.24 13 123471 238 42497613
Paraneoplastic encephalomyelitis 25.07 13.24 7 123477 18 42497833
Demyelinating polyneuropathy 24.88 13.24 27 123457 1597 42496254
Endocrine toxicity 24.80 13.24 7 123477 19 42497832
Impaired work ability 24.66 13.24 3 123481 12088 42485763
Skin discolouration 24.61 13.24 15 123469 20875 42476976
Blister 24.55 13.24 26 123458 27464 42470387
Ameloblastoma 24.52 13.24 10 123474 103 42497748
Pericardial effusion 24.51 13.24 157 123327 29118 42468733
Radiation mucositis 24.46 13.24 13 123471 254 42497597
Metastases to skin 24.34 13.24 17 123467 551 42497300
Lung abscess 24.32 13.24 38 123446 3225 42494626
Neuroblastoma recurrent 24.16 13.24 15 123469 397 42497454
Micturition urgency 24.15 13.24 3 123481 11895 42485956
Subdural haematoma 24.09 13.24 19 123465 23119 42474732
Transplant rejection 24.06 13.24 5 123479 13583 42484268
Arteriosclerosis coronary artery 24.05 13.24 12 123472 18665 42479186
Pollakiuria 24.04 13.24 18 123466 22487 42475364
Appendicitis 24.00 13.24 15 123469 20598 42477253
Cellulitis gangrenous 23.83 13.24 13 123471 268 42497583
Pulmonary hypertension 23.74 13.24 20 123464 23549 42474302
Hypothalamo-pituitary disorder 23.69 13.24 22 123462 1078 42496773
Flushing 23.66 13.24 186 123298 36842 42461009
Swelling face 23.57 13.24 27 123457 27527 42470324
Hypersensitivity pneumonitis 23.45 13.24 29 123455 1975 42495876
Hyponatraemia 23.18 13.24 418 123066 101044 42396807
Paraneoplastic syndrome 23.17 13.24 19 123465 787 42497064
Delusion 23.04 13.24 7 123477 14727 42483124
Retinal degeneration 23.04 13.24 18 123466 695 42497156
Deafness neurosensory 23.03 13.24 40 123444 3706 42494145
Malaise 22.91 13.24 455 123029 211701 42286150
Cardiomegaly 22.78 13.24 10 123474 16756 42481095
Chronic kidney disease 22.75 13.24 66 123418 47175 42450676
Hyperhidrosis 22.74 13.24 161 123323 90351 42407500
Acquired tracheo-oesophageal fistula 22.73 13.24 10 123474 126 42497725
Immune-mediated cytopenia 22.55 13.24 11 123473 178 42497673
Noninfectious myelitis 22.53 13.24 6 123478 12 42497839
Organising pneumonia 22.51 13.24 60 123424 7472 42490379
Platelet count abnormal 22.48 13.24 39 123445 3610 42494241
Gout 22.41 13.24 29 123455 28026 42469825
Activated partial thromboplastin time prolonged 22.38 13.24 9 123475 15894 42481957
Skin exfoliation 22.32 13.24 55 123429 41498 42456353
Dry skin 22.22 13.24 69 123415 48269 42449582
Anaphylactic reaction 22.19 13.24 205 123279 42538 42455313
Encephalitis enteroviral 22.17 13.24 11 123473 185 42497666
Infectious pleural effusion 22.15 13.24 36 123448 3159 42494692
Acquired gene mutation 22.02 13.24 25 123459 1555 42496296
Seizure 22.01 13.24 233 123251 120328 42377523
Intervertebral disc protrusion 21.97 13.24 3 123481 11069 42486782
Injection site reaction 21.96 13.24 9 123475 15712 42482139
Iron deficiency 21.94 13.24 3 123481 11058 42486793
Radiation dysphagia 21.89 13.24 5 123479 3 42497848
Blood glucose decreased 21.79 13.24 7 123477 14212 42483639
Miosis 21.74 13.24 6 123478 13440 42484411
Laryngeal necrosis 21.61 13.24 6 123478 15 42497836
Respiratory depression 21.60 13.24 14 123470 18854 42478997
Subacute cutaneous lupus erythematosus 21.52 13.24 24 123460 1464 42496387
Cardiac tamponade 21.51 13.24 54 123430 6486 42491365
Metastases to retroperitoneum 21.47 13.24 12 123472 260 42497591
Papilloedema 21.41 13.24 36 123448 3250 42494601
Immune-mediated myositis 21.39 13.24 39 123445 3754 42494097
Blood phosphorus increased 21.38 13.24 5 123479 12520 42485331
Fulminant type 1 diabetes mellitus 21.33 13.24 23 123461 1351 42496500
Abdominal pain upper 21.21 13.24 146 123338 82463 42415388
Joint injury 21.16 13.24 8 123476 14668 42483183
Hypersomnia 21.02 13.24 8 123476 14610 42483241
Enterocolitis 21.02 13.24 70 123414 9859 42487992
Hypophagia 21.01 13.24 142 123342 26814 42471037
Colitis ulcerative 20.96 13.24 27 123457 26148 42471703
Thermal burns of eye 20.82 13.24 6 123478 18 42497833
Carbamoyl phosphate synthetase deficiency 20.82 13.24 6 123478 18 42497833
Lethargy 20.81 13.24 68 123416 46822 42451029
Peripheral sensorimotor neuropathy 20.80 13.24 27 123457 1931 42495920
Parkinsonism 20.80 13.24 3 123481 10620 42487231
Kounis syndrome 20.76 13.24 36 123448 3332 42494519
Heart rate increased 20.48 13.24 82 123402 53173 42444678
Clinomania 20.43 13.24 7 123477 42 42497809
Pulmonary haemorrhage 20.38 13.24 76 123408 11321 42486530
Limb injury 20.29 13.24 8 123476 14297 42483554
Muscle rigidity 20.22 13.24 5 123479 12054 42485797
Cerebral cavernous malformation 20.16 13.24 7 123477 44 42497807
Neck pain 20.12 13.24 35 123449 29979 42467872
Limb discomfort 20.08 13.24 6 123478 12761 42485090
Full blood count decreased 20.03 13.24 18 123466 20542 42477309
Hip fracture 20.01 13.24 7 123477 13465 42484386
Autoimmune haemolytic anaemia 19.89 13.24 48 123436 5623 42492228
Gastric disorder 19.88 13.24 5 123479 11917 42485934
Respiratory symptom 19.84 13.24 4 123480 11102 42486749
Pneumonia bacterial 19.75 13.24 94 123390 15598 42482253
Erythema 19.75 13.24 433 123051 108360 42389491
Arteriosclerosis 19.72 13.24 14 123470 17975 42479876
Post procedural oedema 19.70 13.24 6 123478 23 42497828
Renal tubular necrosis 19.62 13.24 105 123379 18249 42479602
Tumour associated fever 19.61 13.24 15 123469 561 42497290
Skin disorder 19.54 13.24 99 123385 16845 42481006
Oesophageal fistula 19.52 13.24 12 123472 312 42497539
Pancreatic toxicity 19.51 13.24 7 123477 49 42497802
Iris neovascularisation 19.49 13.24 6 123478 24 42497827
Cytomegalovirus chorioretinitis 19.47 13.24 42 123442 4569 42493282
Drug eruption 19.47 13.24 124 123360 22951 42474900
Infusion related reaction 19.40 13.24 265 123219 60541 42437310
Lip swelling 19.39 13.24 16 123468 19037 42478814
Rectal haemorrhage 19.32 13.24 76 123408 49530 42448321
Tumour cavitation 19.30 13.24 6 123478 25 42497826
Autoimmune hypothyroidism 19.30 13.24 10 123474 185 42497666
Neurotoxicity 19.29 13.24 126 123358 23525 42474326
Pleurocutaneous fistula 19.27 13.24 7 123477 51 42497800
Bronchitis 19.23 13.24 71 123413 47130 42450721
Product administration error 19.18 13.24 15 123469 18328 42479523
Laboratory test abnormal 19.14 13.24 23 123461 22955 42474896
Autoimmune cholangitis 19.11 13.24 6 123478 26 42497825
Pulmonary fistula 19.07 13.24 8 123476 89 42497762
Bacteraemia 18.98 13.24 131 123353 24909 42472942
Red blood cell sedimentation rate increased 18.98 13.24 3 123481 9921 42487930
Faeces discoloured 18.97 13.24 13 123471 17001 42480850
Renal impairment 18.84 13.24 435 123049 109793 42388058
Herpes zoster reactivation 18.76 13.24 13 123471 416 42497435
Acne 18.75 13.24 8 123476 13636 42484215
Skin cancer 18.75 13.24 5 123479 11457 42486394
Eye pruritus 18.62 13.24 5 123479 11407 42486444
Acute generalised exanthematous pustulosis 18.56 13.24 61 123423 8534 42489317
Opsoclonus myoclonus 18.53 13.24 8 123476 96 42497755
Post-acute COVID-19 syndrome 18.49 13.24 13 123471 426 42497425
Mania 18.43 13.24 4 123480 10543 42487308
Embolism venous 18.28 13.24 25 123459 1881 42495970
Chromaturia 18.12 13.24 12 123472 15977 42481874
Hypoaesthesia 18 13.24 127 123357 71336 42426515
Amoebic colitis 17.96 13.24 8 123476 104 42497747
Drug use disorder 17.89 13.24 4 123480 10329 42487522
Squamous cell carcinoma of lung 17.84 13.24 27 123457 2229 42495622
Malignant pleural effusion 17.78 13.24 25 123459 1930 42495921
Ulcer 17.76 13.24 13 123471 16428 42481423
Bladder cancer 17.75 13.24 14 123470 17033 42480818
Electrolyte imbalance 17.72 13.24 97 123387 17004 42480847
Lung squamous cell carcinoma metastatic 17.71 13.24 7 123477 66 42497785
Immune-mediated encephalopathy 17.71 13.24 7 123477 66 42497785
Night sweats 17.71 13.24 19 123465 19950 42477901
Medulloblastoma recurrent 17.70 13.24 8 123476 108 42497743
Large intestine infection 17.65 13.24 26 123458 2095 42495756
Oral fungal infection 17.64 13.24 24 123460 1797 42496054
Lymphocytic hypophysitis 17.60 13.24 12 123472 374 42497477
Empyema 17.57 13.24 38 123446 4142 42493709
Scleroderma-like reaction 17.52 13.24 7 123477 68 42497783
Basal cell naevus syndrome 17.51 13.24 6 123478 36 42497815
Stress cardiomyopathy 17.47 13.24 30 123454 2755 42495096
Loss of consciousness 17.46 13.24 177 123307 92177 42405674
Vena cava thrombosis 17.33 13.24 22 123462 1539 42496312
Cystoid macular oedema 17.29 13.24 18 123466 1015 42496836
Vascular access site swelling 17.16 13.24 4 123480 3 42497848
Liver disorder 17.12 13.24 183 123301 39461 42458390
Glycosylated haemoglobin increased 17.10 13.24 8 123476 12916 42484935
Gliosis 17.09 13.24 10 123474 237 42497614
Neuroblastoma 17.04 13.24 11 123473 312 42497539
Hyperkalaemia 17.01 13.24 150 123334 80308 42417543
Flagellate dermatitis 17.00 13.24 8 123476 119 42497732
Adenomatous polyposis coli 16.97 13.24 9 123475 175 42497676
Pathogen resistance 16.92 13.24 6 123478 11444 42486407
Speech disorder 16.88 13.24 37 123447 29084 42468767
Withdrawal syndrome 16.86 13.24 11 123473 14764 42483087
Diabetes mellitus inadequate control 16.84 13.24 12 123472 15378 42482473
Tendonitis 16.79 13.24 4 123480 9890 42487961
Hepatitis viral 16.74 13.24 16 123468 813 42497038
Skin laceration 16.69 13.24 10 123474 14048 42483803
Melaena 16.64 13.24 57 123427 38689 42459162
Oral papule 16.63 13.24 4 123480 4 42497847
Autoimmune lung disease 16.44 13.24 7 123477 81 42497770
Odynophagia 16.41 13.24 50 123434 6720 42491131
Radiation necrosis 16.40 13.24 10 123474 256 42497595
Genital tract inflammation 16.37 13.24 6 123478 45 42497806
Discomfort 16.37 13.24 30 123454 25189 42472662
Immune-mediated neuropathy 16.37 13.24 7 123477 82 42497769
Gynaecomastia 16.29 13.24 8 123476 12559 42485292
Occipital neuralgia 16.15 13.24 6 123478 47 42497804
Mood swings 16.15 13.24 3 123481 8823 42489028
Gastritis bacterial 16.13 13.24 11 123473 343 42497508
Encephalopathy 16.11 13.24 187 123297 41146 42456705
Miller Fisher syndrome 16.10 13.24 8 123476 135 42497716
Disseminated intravascular coagulation 16.09 13.24 125 123359 24669 42473182
Muscle twitching 16.04 13.24 7 123477 11773 42486078
Autoimmune neutropenia 16.01 13.24 11 123473 347 42497504
Paraneoplastic rash 16.00 13.24 7 123477 87 42497764
Metastases to kidney 15.99 13.24 11 123473 348 42497503
Autoimmune dermatitis 15.93 13.24 6 123478 49 42497802
Diabetes insipidus 15.89 13.24 34 123450 3679 42494172
Device leakage 15.88 13.24 5 123479 10280 42487571
Follicular lymphoma 15.87 13.24 12 123472 441 42497410
Coronary artery occlusion 15.85 13.24 6 123478 10991 42486860
Cellulitis 15.73 13.24 109 123375 61476 42436375
Adenoviral hepatitis 15.70 13.24 13 123471 546 42497305
Dry mouth 15.59 13.24 61 123423 39818 42458033
Pharyngeal inflammation 15.57 13.24 14 123470 658 42497193
Acute febrile neutrophilic dermatosis 15.54 13.24 23 123461 1861 42495990
Electrocardiogram abnormal 15.54 13.24 5 123479 10140 42487711
Myeloblast count increased 15.52 13.24 5 123479 24 42497827
Pyopneumothorax 15.42 13.24 6 123478 54 42497797
Rickets 15.42 13.24 6 123478 54 42497797
Dysstasia 15.39 13.24 11 123473 14075 42483776
Myeloproliferative neoplasm 15.38 13.24 15 123469 782 42497069
Atrial flutter 15.37 13.24 94 123390 17157 42480694
Mucosal hyperaemia 15.35 13.24 5 123479 25 42497826
Disorientation 15.31 13.24 54 123430 36335 42461516
Hepatic cancer 15.26 13.24 3 123481 8477 42489374
Transaminases increased 15.24 13.24 154 123330 32731 42465120
Uveitis 15.21 13.24 4 123480 9254 42488597
Rales 15.17 13.24 7 123477 11393 42486458
Systemic toxicity 15.14 13.24 6 123478 57 42497794
Right ventricular ejection fraction decreased 15.14 13.24 6 123478 57 42497794
Drug level decreased 15.14 13.24 5 123479 9972 42487879
Skin reaction 15.12 13.24 50 123434 7017 42490834
Resorption bone increased 15.12 13.24 10 123474 296 42497555
Pneumonia adenoviral 15.09 13.24 11 123473 382 42497469
Gastrointestinal mucosal disorder 14.93 13.24 12 123472 483 42497368
Hepatic enzyme increased 14.90 13.24 75 123409 45709 42452142
Hypokinesia 14.88 13.24 5 123479 9866 42487985
Choroidal dystrophy 14.73 13.24 5 123479 29 42497822
Abnormal dreams 14.73 13.24 3 123481 8268 42489583
Pelvic mass 14.71 13.24 9 123475 232 42497619
Secondary cerebellar degeneration 14.70 13.24 4 123480 9 42497842
Premature baby 14.62 13.24 28 123456 23125 42474726
Renal cancer 14.61 13.24 3 123481 8221 42489630
Cancer with a high tumour mutational burden 14.59 13.24 5 123479 30 42497821
Ventricular fibrillation 14.56 13.24 42 123442 30081 42467770
Blood loss anaemia 14.56 13.24 5 123479 9731 42488120
Gastrin-releasing peptide precursor increased 14.54 13.24 3 123481 0 42497851
Cytokine abnormal 14.54 13.24 3 123481 0 42497851
Pulmonary resection 14.53 13.24 7 123477 110 42497741
Iron deficiency anaemia 14.49 13.24 10 123474 13029 42484822
Vertigo 14.43 13.24 51 123433 34296 42463555
Colon cancer 14.43 13.24 5 123479 9676 42488175
Blood urine present 14.42 13.24 8 123476 11725 42486126
Cytomegalovirus viraemia 14.40 13.24 6 123478 10371 42487480
Device malfunction 14.31 13.24 9 123475 12318 42485533
Dysarthria 14.25 13.24 63 123421 39744 42458107
Eye pain 14.23 13.24 17 123467 17013 42480838
Respiratory arrest 14.21 13.24 39 123445 28385 42469466
Infected neoplasm 14.20 13.24 8 123476 176 42497675
Blood creatine phosphokinase increased 14.17 13.24 82 123402 48256 42449595
Paraneoplastic retinopathy 14.13 13.24 4 123480 11 42497840
Aortic injury 14.13 13.24 4 123480 11 42497840
Troponin abnormal 14.13 13.24 6 123478 69 42497782
Dyspnoea 14.09 13.24 1476 122008 441145 42056706
Salivary gland cancer stage IV 14.06 13.24 5 123479 34 42497817
Extravasation 14.02 13.24 25 123459 2365 42495486
Dysentery 13.98 13.24 11 123473 429 42497422
Aortic stenosis 13.95 13.24 4 123480 8741 42489110
Optic nerve injury 13.92 13.24 8 123476 183 42497668
Mucosal pain 13.88 13.24 4 123480 12 42497839
Liver scan abnormal 13.88 13.24 4 123480 12 42497839
Urinary incontinence 13.86 13.24 26 123458 21642 42476209
Nocturia 13.85 13.24 9 123475 12103 42485748
Tumour pain 13.85 13.24 18 123466 1289 42496562
T-cell lymphoma refractory 13.82 13.24 5 123479 36 42497815
Dyslipidaemia 13.80 13.24 5 123479 9413 42488438
Vasogenic cerebral oedema 13.78 13.24 16 123468 1020 42496831
Gastrointestinal disorder 13.75 13.24 79 123405 46574 42451277
Angina pectoris 13.72 13.24 49 123435 32847 42465004
Food protein-induced enterocolitis syndrome 13.70 13.24 5 123479 37 42497814
Renal tubular dysfunction 13.68 13.24 11 123473 443 42497408
Blastic plasmacytoid dendritic cell neoplasia 13.61 13.24 6 123478 76 42497775
Lung infiltration 13.60 13.24 78 123406 13911 42483940
Laryngeal pain 13.59 13.24 26 123458 2596 42495255
Glomerulonephritis rapidly progressive 13.58 13.24 15 123469 905 42496946
Peptic ulcer perforation 13.57 13.24 10 123474 353 42497498
Tooth disorder 13.56 13.24 9 123475 11970 42485881
Meningitis tuberculous 13.52 13.24 13 123471 666 42497185
Large intestine polyp 13.44 13.24 5 123479 9260 42488591
Eye swelling 13.44 13.24 9 123475 11911 42485940
IIIrd nerve paralysis 13.43 13.24 12 123472 559 42497292
Retinoblastoma 13.41 13.24 4 123480 14 42497837
Acute myelomonocytic leukaemia 13.40 13.24 8 123476 197 42497654
Angiodysplasia 13.40 13.24 14 123470 793 42497058
Cancer pain 13.39 13.24 31 123453 3536 42494315
Chromosome analysis abnormal 13.29 13.24 8 123476 200 42497651
Eyelid ptosis 13.26 13.24 46 123438 6615 42491236
Blood calcium increased 13.25 13.24 4 123480 8450 42489401
Metastases to abdominal cavity 13.24 13.24 9 123475 279 42497572
Respiratory tract congestion 13.24 13.24 3 123481 7675 42490176

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myelosuppression 4441.32 12.31 2834 275638 91506 110219321
Malignant neoplasm progression 4157.62 12.31 3471 275001 171096 110139731
Febrile neutropenia 4083.82 12.31 4486 273986 312281 109998546
Neutropenia 3884.86 12.31 4742 273730 369878 109940949
Disease progression 3396.77 12.31 3601 274871 240433 110070394
Thrombocytopenia 2806.45 12.31 3899 274573 344986 109965841
Pancytopenia 2621.64 12.31 2925 275547 206688 110104139
Anaemia 2559.08 12.31 4775 273697 542311 109768516
Neutrophil count decreased 1803.75 12.31 1854 276618 119087 110191740
Therapy partial responder 1620.51 12.31 1064 277408 35997 110274830
Neuropathy peripheral 1149.87 12.31 1804 276668 177473 110133354
Haematotoxicity 1148.94 12.31 696 277776 20386 110290441
Neoplasm progression 1066.63 12.31 1047 277425 63548 110247279
Mucosal inflammation 1026.22 12.31 1238 277234 94903 110215924
Leukopenia 956.33 12.31 1499 276973 147292 110163535
Joint swelling 890.63 12.31 57 278415 442788 109868039
Acute myeloid leukaemia 868.29 12.31 740 277732 37370 110273457
Neutropenic sepsis 828.11 12.31 658 277814 30088 110280739
Immune-mediated enterocolitis 825.24 12.31 436 278036 9749 110301078
Erythema 777.43 12.31 2035 276437 289412 110021415
Pain 755.78 12.31 776 277696 954179 109356648
Bone marrow failure 748.63 12.31 823 277649 57025 110253802
Interstitial lung disease 740.75 12.31 1289 277183 138045 110172782
Myelodysplastic syndrome 722.45 12.31 662 277810 36822 110274005
Hypothyroidism 718.52 12.31 902 277570 71997 110238830
Pneumonitis 713.36 12.31 921 277551 75610 110235217
Nasopharyngitis 695.68 12.31 87 278385 394274 109916553
Platelet count decreased 694.79 12.31 1686 276786 228757 110082070
Immune-mediated hepatic disorder 681.17 12.31 295 278177 4155 110306672
Febrile bone marrow aplasia 675.93 12.31 465 278007 17000 110293827
Weight increased 668.58 12.31 124 278348 419520 109891307
Synovitis 656.56 12.31 6 278466 274086 110036741
Colitis 636.64 12.31 1016 277456 101307 110209520
Product dose omission issue 627.66 12.31 48 278424 321734 109989093
Immune-mediated lung disease 622.31 12.31 292 278180 5011 110305816
Metastases to central nervous system 600.97 12.31 482 277990 22335 110288492
Peripheral swelling 593.22 12.31 144 278328 403890 109906937
Completed suicide 586.88 12.31 4 278468 242377 110068450
Fall 586.64 12.31 401 278071 603081 109707746
Anaphylactic shock 583.15 12.31 684 277788 50862 110259965
White blood cell count decreased 575.25 12.31 1566 276906 227824 110083003
Flushing 568.39 12.31 978 277494 103758 110207069
Headache 563.39 12.31 845 277627 881532 109429295
Arthropathy 538.52 12.31 51 278421 287471 110023356
Immune-mediated hypothyroidism 535.01 12.31 219 278253 2656 110308171
Swelling 531.41 12.31 117 278355 350924 109959903
Musculoskeletal stiffness 528.44 12.31 48 278424 279774 110031053
Skin toxicity 519.03 12.31 340 278132 11443 110299384
Hand deformity 517.64 12.31 6 278466 218500 110092327
Immune-mediated hepatitis 514.73 12.31 277 278195 6434 110304393
Glossodynia 513.41 12.31 9 278463 221995 110088832
Hepatic cytolysis 509.01 12.31 660 277812 54393 110256434
Arthralgia 501.92 12.31 742 277730 778890 109531937
Pemphigus 499.11 12.31 8 278464 214562 110096265
Therapeutic product effect decreased 498.24 12.31 29 278443 244287 110066540
Rheumatoid arthritis 493.51 12.31 81 278391 299532 110011295
Sinusitis 486.92 12.31 81 278391 296607 110014220
Abdominal discomfort 480.74 12.31 195 278277 393663 109917164
Wound 480.61 12.31 27 278445 234410 110076417
Contraindicated product administered 475.81 12.31 40 278432 248227 110062600
Hyperthyroidism 473.01 12.31 469 278003 28792 110282035
Off label use 471.94 12.31 5800 272672 1494385 108816442
Immune-mediated adrenal insuficiency 467.19 12.31 174 278298 1606 110309221
Radiation pneumonitis 466.09 12.31 228 278244 4308 110306519
Systemic lupus erythematosus 463.56 12.31 50 278422 254288 110056539
Psoriatic arthropathy 450.81 12.31 9 278463 196752 110114075
Helicobacter infection 426.34 12.31 6 278466 181871 110128956
Metastases to liver 414.32 12.31 478 277994 34908 110275919
Overdose 408.62 12.31 53 278419 233741 110077086
Immune-mediated dermatitis 400.93 12.31 167 278305 2123 110308704
Drug abuse 399.08 12.31 10 278462 177401 110133426
Fibromyalgia 399.05 12.31 6 278466 170903 110139924
Second primary malignancy 397.57 12.31 344 278128 17724 110293103
Blood cholesterol increased 392.40 12.31 17 278455 184768 110126059
Irritable bowel syndrome 386.73 12.31 5 278467 164210 110146617
Duodenal ulcer perforation 385.30 12.31 14 278458 177686 110133141
Mobility decreased 378.21 12.31 70 278402 237352 110073475
Myocarditis 370.53 12.31 417 278055 29638 110281189
Hypokalaemia 370.08 12.31 1155 277317 181293 110129534
Depression 369.80 12.31 168 278304 317167 109993660
Asthma 367.56 12.31 89 278383 250202 110060625
Maternal exposure during pregnancy 365.86 12.31 95 278377 254788 110056039
Injury 364.59 12.31 20 278452 177245 110133582
Insomnia 356.17 12.31 235 278237 360355 109950472
Blister 355.89 12.31 70 278402 227306 110083521
Hypomagnesaemia 355.71 12.31 585 277887 59785 110251042
Septic shock 355.03 12.31 1035 277437 156493 110154334
Contusion 344.59 12.31 82 278390 233279 110077548
Metastases to bone 339.43 12.31 407 278065 30965 110279862
Polyneuropathy 332.82 12.31 407 278065 31605 110279222
Injection site pain 326.66 12.31 34 278438 177888 110132939
Hepatic enzyme increased 325.27 12.31 203 278269 320689 109990138
Immune-mediated myocarditis 324.42 12.31 164 278308 3334 110307493
Muscle injury 324.31 12.31 6 278466 140801 110170026
Adrenal insufficiency 323.34 12.31 463 278009 41927 110268900
Cytopenia 321.40 12.31 388 278084 29728 110281099
Sepsis 321.34 12.31 1651 276821 325695 109985132
Osteoarthritis 320.06 12.31 41 278431 182582 110128245
Discomfort 319.88 12.31 74 278398 214633 110096194
Metastases to lung 319.07 12.31 340 278132 22723 110288104
Drug intolerance 311.95 12.31 338 278134 406174 109904653
Migraine 309.54 12.31 35 278437 171617 110139210
Nausea 304.82 12.31 4577 273895 1231113 109079714
Tumour lysis syndrome 304.78 12.31 382 278090 30419 110280408
Ototoxicity 301.49 12.31 165 278307 3966 110306861
Wheezing 299.07 12.31 134 278338 255096 110055731
Pericarditis 295.33 12.31 92 278380 219022 110091805
Impaired healing 292.65 12.31 68 278404 196649 110114178
Pain in extremity 292.58 12.31 485 277987 486633 109824194
Pyrexia 290.87 12.31 3496 274976 894769 109416058
Sleep disorder 288.97 12.31 72 278400 198572 110112255
Muscle spasms 286.00 12.31 173 278299 277984 110032843
Bursitis 282.45 12.31 10 278462 129908 110180919
Tubulointerstitial nephritis 281.49 12.31 497 277975 53787 110257040
Pulmonary toxicity 280.46 12.31 281 278191 17465 110293362
Peripheral sensory neuropathy 274.49 12.31 270 278202 16410 110294417
Folliculitis 274.45 12.31 46 278426 167607 110143220
Diarrhoea 273.15 12.31 4201 274271 1135304 109175523
Joint range of motion decreased 269.77 12.31 8 278464 121824 110189003
Oesophagitis 269.68 12.31 347 278125 28368 110282459
Loss of personal independence in daily activities 269.47 12.31 31 278441 149989 110160838
Memory impairment 264.86 12.31 83 278389 196861 110113966
Type 2 diabetes mellitus 256.32 12.31 65 278407 177167 110133660
Rash maculo-papular 249.42 12.31 567 277905 73655 110237172
Lower respiratory tract infection 247.40 12.31 153 278319 242953 110067874
C-reactive protein abnormal 245.40 12.31 22 278450 129673 110181154
Anxiety 245.18 12.31 305 278167 344773 109966054
Non-small cell lung cancer 242.32 12.31 183 278289 7752 110303075
Lichenoid keratosis 241.97 12.31 167 278305 6135 110304692
Condition aggravated 241.27 12.31 992 277480 733844 109576983
Renal salt-wasting syndrome 241.12 12.31 89 278383 799 110310028
Cytokine release syndrome 239.49 12.31 540 277932 69766 110241061
Obesity 235.53 12.31 12 278460 113339 110197488
Radiotherapy 235.48 12.31 101 278371 1387 110309440
Dyspnoea 230.17 12.31 3987 274485 1102885 109207942
Intentional product misuse 230.08 12.31 31 278441 132873 110177954
Facet joint syndrome 227.73 12.31 3 278469 96825 110214002
Lip dry 227.53 12.31 5 278467 100078 110210749
Hypophysitis 225.77 12.31 151 278321 5264 110305563
Dehydration 225.44 12.31 1337 277135 278174 110032653
Exposure during pregnancy 224.33 12.31 71 278401 167353 110143474
Cardiotoxicity 223.22 12.31 243 278229 16638 110294189
Adrenocorticotropic hormone deficiency 219.18 12.31 108 278364 2074 110308753
Decreased appetite 213.30 12.31 1979 276493 473867 109836960
Thyroiditis 212.80 12.31 157 278315 6416 110304411
Road traffic accident 212.17 12.31 15 278457 107383 110203444
Neutropenic colitis 211.56 12.31 170 278302 7895 110302932
Suicide attempt 211.54 12.31 12 278460 103382 110207445
Hepatic function abnormal 210.08 12.31 596 277876 88699 110222128
Hypertransaminasaemia 209.04 12.31 281 278191 23974 110286853
Metastases to meninges 206.62 12.31 140 278332 4988 110305839
Drug hypersensitivity 205.05 12.31 532 277940 453558 109857269
Nephritis 202.11 12.31 148 278324 5978 110304849
Hypopituitarism 201.49 12.31 130 278342 4260 110306567
Vomiting 201.35 12.31 3314 275158 907361 109403466
Dizziness 200.62 12.31 990 277482 697203 109613624
Stress 198.96 12.31 18 278454 105330 110205497
Confusional state 197.47 12.31 568 277904 468112 109842715
Metastases to lymph nodes 196.36 12.31 215 278257 14817 110296010
Acute kidney injury 196.04 12.31 2452 276020 632978 109677849
Type I hypersensitivity 194.25 12.31 147 278325 6246 110304581
Drug interaction 193.78 12.31 630 277842 499553 109811274
Immune-mediated hypophysitis 193.77 12.31 78 278394 903 110309924
Gastrooesophageal reflux disease 193.40 12.31 106 278366 179870 110130957
Pleural effusion 192.41 12.31 922 277550 176787 110134040
Night sweats 192.07 12.31 50 278422 133933 110176894
Asthenia 191.36 12.31 2608 275864 686391 109624436
Sciatica 191.29 12.31 10 278462 92389 110218438
Hospitalisation 189.88 12.31 61 278411 142432 110168395
Pulmonary embolism 189.30 12.31 1051 277421 213423 110097404
Disease recurrence 188.51 12.31 450 278022 60334 110250493
Bicytopenia 185.51 12.31 146 278326 6578 110304249
Ovarian cancer recurrent 185.35 12.31 68 278404 599 110310228
Proteinuria 184.18 12.31 348 278124 39670 110271157
Influenza 182.57 12.31 99 278373 169002 110141825
Somnolence 181.37 12.31 293 278179 297156 110013671
Gait inability 180.63 12.31 59 278413 136317 110174510
Treatment failure 178.70 12.31 263 278209 276971 110033856
Haemoptysis 177.44 12.31 486 277986 70868 110239959
Anaphylactic reaction 176.64 12.31 661 277811 113639 110197188
Suicidal ideation 172.26 12.31 18 278454 93919 110216908
Product use in unapproved indication 171.85 12.31 1802 276670 445575 109865252
Feeling abnormal 171.33 12.31 123 278349 180588 110130239
Arthritis 171.12 12.31 105 278367 167481 110143346
Immune-mediated hyperthyroidism 170.73 12.31 63 278409 565 110310262
Lower limb fracture 170.36 12.31 4 278468 75344 110235483
Gait disturbance 169.66 12.31 274 278198 277934 110032893
Eastern Cooperative Oncology Group performance status worsened 169.44 12.31 101 278371 2868 110307959
Agranulocytosis 167.07 12.31 434 278038 61326 110249501
Red blood cell sedimentation rate increased 166.87 12.31 7 278465 78295 110232532
Posterior reversible encephalopathy syndrome 166.55 12.31 303 278169 33558 110277269
Aplasia 165.37 12.31 146 278326 7727 110303100
Injection site erythema 162.92 12.31 22 278450 94154 110216673
Metastases to peritoneum 161.68 12.31 125 278347 5485 110305342
Palmar erythema 161.33 12.31 90 278382 2248 110308579
Intentional product use issue 160.91 12.31 234 278238 247672 110063155
Injection site reaction 156.02 12.31 20 278452 89050 110221777
Drug resistance 155.42 12.31 399 278073 55975 110254852
Metastasis 155.35 12.31 144 278328 8123 110302704
Diffuse large B-cell lymphoma recurrent 155.17 12.31 128 278344 6171 110304656
Gastrointestinal toxicity 153.58 12.31 164 278308 10984 110299843
Immune-mediated renal disorder 153.11 12.31 61 278411 686 110310141
Dry mouth 152.39 12.31 167 278305 199781 110111046
Product quality issue 152.10 12.31 11 278461 77288 110233539
Blood pressure fluctuation 152.10 12.31 9 278463 74815 110236012
Renal tubular disorder 150.54 12.31 135 278337 7294 110303533
Toxicity to various agents 150.53 12.31 660 277812 479895 109830932
Gastrointestinal perforation 150.12 12.31 135 278337 7321 110303506
Illness 150.02 12.31 16 278456 82155 110228672
Amnesia 149.82 12.31 40 278432 105368 110205459
Neoplasm recurrence 149.53 12.31 116 278356 5116 110305711
Radiation oesophagitis 149.15 12.31 63 278409 831 110309996
Live birth 148.78 12.31 6 278466 69478 110241349
Tumour pseudoprogression 144.72 12.31 74 278398 1542 110309285
Peripheral venous disease 144.68 12.31 20 278452 84097 110226730
Immune-mediated pancreatitis 144.50 12.31 58 278414 666 110310161
Psoriasis 143.91 12.31 87 278385 139906 110170921
Haemophagocytic lymphohistiocytosis 143.45 12.31 273 278199 31286 110279541
Sedation 142.81 12.31 8 278464 69675 110241152
Musculoskeletal pain 142.67 12.31 150 278322 182873 110127954
Pneumothorax 141.97 12.31 290 278182 34995 110275832
Ill-defined disorder 141.96 12.31 112 278360 156741 110154086
Hypercholesterolaemia 139.91 12.31 29 278443 90808 110220019
Immune-mediated thyroiditis 136.83 12.31 63 278409 1033 110309794
Bronchospasm 136.73 12.31 261 278211 29978 110280849
Urticaria 135.25 12.31 385 278087 318472 109992355
Enterocolitis 134.37 12.31 200 278272 18749 110292078
Hallucination 134.11 12.31 44 278428 101388 110209439
Medication error 133.64 12.31 49 278423 105317 110205510
Inflammation 132.80 12.31 175 278297 193063 110117764
Hepatotoxicity 132.71 12.31 406 278066 62994 110247833
Bradycardia 130.99 12.31 119 278353 155398 110155429
Upper respiratory tract infection 128.97 12.31 86 278386 131242 110179585
Injection site swelling 126.92 12.31 7 278465 61783 110249044
Joint stiffness 125.60 12.31 12 278460 67231 110243596
Bronchitis 123.17 12.31 128 278344 156904 110153923
Epistaxis 122.48 12.31 650 277822 129722 110181105
Recall phenomenon 122.34 12.31 63 278409 1333 110309494
Immune-mediated arthritis 120.93 12.31 50 278422 623 110310204
Neurotoxicity 120.79 12.31 303 278169 41904 110268923
Respiratory failure 116.95 12.31 935 277537 214397 110096430
Adverse drug reaction 116.58 12.31 60 278412 105499 110205328
Hypoaesthesia 115.95 12.31 404 278068 313819 109997008
Erythema multiforme 114.35 12.31 197 278275 20900 110289927
Immune-mediated encephalitis 113.90 12.31 57 278415 1133 110309694
Heart rate decreased 112.80 12.31 34 278438 82722 110228105
Thrombotic microangiopathy 111.91 12.31 235 278237 28914 110281913
Cholangitis 110.98 12.31 169 278303 16166 110294661
Nephrolithiasis 110.95 12.31 17 278455 66195 110244632
Choroidal infarction 110.82 12.31 35 278437 184 110310643
Cardiac failure congestive 110.82 12.31 130 278342 150870 110159957
Wound infection 110.82 12.31 52 278420 96413 110214414
Immune-mediated adverse reaction 110.70 12.31 63 278409 1637 110309190
Lymphangiosis carcinomatosa 110.23 12.31 72 278400 2410 110308417
Toxic skin eruption 109.35 12.31 225 278247 27290 110283537
Renal tubular necrosis 109.31 12.31 239 278233 30236 110280591
Dermatitis acneiform 109.27 12.31 147 278325 12548 110298279
Immune-mediated nephritis 109.13 12.31 56 278416 1176 110309651
Prescribed overdose 108.94 12.31 42 278430 87539 110223288
Metastatic neoplasm 107.85 12.31 101 278371 5772 110305055
Incorrect dose administered 107.09 12.31 64 278408 103577 110207250
General physical health deterioration 107.03 12.31 1583 276889 423712 109887115
Serotonin syndrome 106.76 12.31 12 278460 59141 110251686
Autoimmune haemolytic anaemia 106.04 12.31 132 278340 10435 110300392
Acquired gene mutation 105.78 12.31 73 278399 2681 110308146
Papilloedema 105.62 12.31 111 278361 7298 110303529
Frequent bowel movements 105.49 12.31 25 278447 71365 110239462
Glucocorticoid deficiency 105.49 12.31 54 278418 1128 110309699
Blood pressure increased 105.16 12.31 318 278154 258055 110052772
Autoimmune disorder 104.87 12.31 19 278453 65464 110245363
EGFR gene mutation 104.63 12.31 43 278429 527 110310300
Nasal congestion 103.95 12.31 59 278413 98223 110212604
Product use issue 103.76 12.31 418 278054 311277 109999550
Plasma cell myeloma 103.56 12.31 17 278455 62919 110247908
Immune-mediated gastritis 103.42 12.31 37 278435 301 110310526
Osteoporosis 101.63 12.31 46 278426 87106 110223721
Tremor 100.60 12.31 225 278247 202007 110108820
Paraneoplastic neurological syndrome 100.44 12.31 31 278441 149 110310678
Inappropriate antidiuretic hormone secretion 100.01 12.31 246 278226 33605 110277222
Blood pressure systolic increased 99.64 12.31 42 278430 82949 110227878
Granulocyte count decreased 98.40 12.31 81 278391 3893 110306934
Adverse event 98.06 12.31 78 278394 108731 110202096
Large intestine perforation 97.73 12.31 161 278311 16468 110294359
Dysphagia 97.51 12.31 692 277780 152908 110157919
Type 1 diabetes mellitus 97.24 12.31 117 278355 8930 110301897
Neck pain 96.97 12.31 100 278372 123030 110187797
Nephropathy toxic 96.86 12.31 214 278258 27264 110283563
Drug dependence 95.93 12.31 8 278464 50012 110260815
Hydronephrosis 95.45 12.31 180 278292 20485 110290342
Coeliac disease 95.00 12.31 3 278469 43184 110267643
Fluid retention 94.99 12.31 60 278412 94247 110216580
Radiation skin injury 94.39 12.31 56 278416 1576 110309251
Oxygen saturation decreased 93.77 12.31 697 277775 156285 110154542
Small intestinal perforation 93.61 12.31 82 278390 4294 110306533
Lactic acidosis 93.55 12.31 59 278413 92752 110218075
Pericardial effusion 93.51 12.31 337 278135 56880 110253947
Electrocardiogram QT prolonged 93.40 12.31 82 278390 108878 110201949
Back injury 92.52 12.31 7 278465 47392 110263435
Intestinal perforation 92.51 12.31 179 278293 20765 110290062
Ileus 91.52 12.31 224 278248 30505 110280322
Cholestasis 91.37 12.31 363 278109 64155 110246672
Product prescribing error 91.18 12.31 11 278461 51320 110259507
Lymphadenopathy mediastinal 90.65 12.31 89 278383 5395 110305432
Pseudocellulitis 90.03 12.31 36 278436 409 110310418
Weight decreased 89.47 12.31 751 277721 467306 109843521
Dermatitis 89.46 12.31 209 278263 27628 110283199
Gastrointestinal disorder 89.28 12.31 311 278161 241641 110069186
Aortitis 88.39 12.31 58 278414 1957 110308870
Ejection fraction decreased 87.62 12.31 264 278208 40616 110270211
Treatment noncompliance 87.53 12.31 37 278435 72953 110237874
Dyspepsia 87.40 12.31 222 278250 190743 110120084
Hyponatraemia 87.36 12.31 885 277587 216768 110094059
Immune thrombocytopenia 87.11 12.31 182 278290 22312 110288515
Palmar-plantar erythrodysaesthesia syndrome 87.06 12.31 264 278208 40761 110270066
Incorrect route of product administration 86.08 12.31 27 278445 64034 110246793
Thrombophlebitis migrans 85.85 12.31 41 278431 733 110310094
Secondary cerebellar degeneration 85.61 12.31 23 278449 59 110310768
Bronchial fistula 84.40 12.31 30 278442 239 110310588
Autoimmune colitis 84.31 12.31 56 278416 1929 110308898
Myositis 83.46 12.31 218 278254 30898 110279929
Performance status decreased 83.11 12.31 97 278375 7169 110303658
Onychomadesis 83.08 12.31 9 278463 45654 110265173
Hypocalcaemia 81.75 12.31 354 278118 65012 110245815
Encephalitis autoimmune 81.33 12.31 69 278403 3459 110307368
Nightmare 81.09 12.31 4 278468 38859 110271968
Stress cardiomyopathy 80.99 12.31 144 278328 15662 110295165
Fulminant type 1 diabetes mellitus 80.02 12.31 58 278414 2305 110308522
Basal cell carcinoma 79.68 12.31 10 278462 45260 110265567
Myasthenic syndrome 79.64 12.31 46 278426 1230 110309597
Encephalitis 79.56 12.31 158 278314 18681 110292146
Microvascular coronary artery disease 79.37 12.31 32 278440 372 110310455
Psychotic disorder 78.98 12.31 16 278456 50921 110259906
Embolism 77.88 12.31 144 278328 16145 110294682
Immune-mediated cholangitis 77.78 12.31 40 278432 844 110309983
Infusion related hypersensitivity reaction 77.73 12.31 40 278432 845 110309982
Metastases to pleura 77.63 12.31 54 278418 2009 110308818
Guillain-Barre syndrome 77.04 12.31 114 278358 10630 110300197
Tracheo-oesophageal fistula 76.95 12.31 37 278435 672 110310155
Metastases to skin 76.88 12.31 56 278416 2243 110308584
Rhinorrhoea 76.83 12.31 87 278385 102579 110208248
Administration site extravasation 76.41 12.31 50 278422 1679 110309148
Urogenital fistula 76.38 12.31 32 278440 413 110310414
Malignant pleural effusion 76.34 12.31 71 278401 4022 110306805
Sense of oppression 76.12 12.31 49 278423 1599 110309228
Hepatic cirrhosis 75.32 12.31 38 278434 67588 110243239
Haemolytic anaemia 74.95 12.31 164 278308 20756 110290071
Liver injury 74.26 12.31 168 278304 150245 110160582
Feeling hot 74.10 12.31 437 278035 90669 110220158
Muscle spasticity 73.98 12.31 4 278468 35911 110274916
Constipation 73.91 12.31 1289 277183 356497 109954330
Sleep apnoea syndrome 73.51 12.31 8 278464 40439 110270388
Joint dislocation 73.04 12.31 3 278469 34187 110276640
Disseminated intravascular coagulation 72.48 12.31 249 278223 41037 110269790
Device related thrombosis 72.31 12.31 64 278408 3398 110307429
Localised infection 72.25 12.31 11 278461 43037 110267790
Hypoglycaemia 72.00 12.31 113 278359 115991 110194836
Dermatomyositis 71.89 12.31 71 278401 4335 110306492
Tumour necrosis 71.78 12.31 55 278417 2381 110308446
Anaplastic lymphoma kinase gene mutation 71.59 12.31 23 278449 129 110310698
Accidental overdose 71.18 12.31 21 278451 51813 110259014
Retinal pigment epitheliopathy 71.00 12.31 32 278440 498 110310329
Prescribed underdose 70.55 12.31 38 278434 65136 110245691
Influenza like illness 70.53 12.31 71 278401 88341 110222486
Subileus 70.42 12.31 84 278388 6353 110304474
Cataract 70.35 12.31 58 278414 79427 110231400
Ovarian cancer metastatic 70.20 12.31 36 278436 755 110310072
Rhabdomyolysis 70.18 12.31 122 278350 120279 110190548
Myocardial infarction 70.12 12.31 248 278224 191835 110118992
Deep vein thrombosis 69.80 12.31 596 277876 139291 110171536
Subacute cutaneous lupus erythematosus 69.74 12.31 74 278398 4920 110305907
Non-small cell lung cancer metastatic 69.46 12.31 43 278429 1309 110309518
Renal impairment 69.37 12.31 753 277719 187692 110123135
Dermatitis bullous 69.25 12.31 143 278329 17386 110293441
Underdose 68.88 12.31 37 278435 63517 110247310
Abdominal distension 68.76 12.31 219 278253 174884 110135943
Laryngitis 68.58 12.31 12 278460 42399 110268428
Retinitis 68.51 12.31 3 278469 32324 110278503
Abdominal pain upper 68.10 12.31 557 277915 348554 109962273
Drug level increased 68.01 12.31 18 278454 47701 110263126
Full blood count abnormal 67.87 12.31 28 278444 56024 110254803
Alveolar soft part sarcoma 67.75 12.31 20 278452 80 110310747
Drug reaction with eosinophilia and systemic symptoms 67.72 12.31 64 278408 82031 110228796
Pulmonary radiation injury 67.13 12.31 19 278453 63 110310764
Cardiac disorder 67.09 12.31 56 278416 76224 110234603
Injection site haemorrhage 67.04 12.31 4 278468 33024 110277803
Onychomycosis 66.64 12.31 9 278463 38522 110272305
Cholangitis sclerosing 66.54 12.31 62 278410 3520 110307307
Unevaluable event 66.39 12.31 33 278439 59194 110251633
Secondary adrenocortical insufficiency 66.03 12.31 68 278404 4366 110306461
Venoocclusive liver disease 65.99 12.31 129 278343 15078 110295749
Acute promyelocytic leukaemia 65.26 12.31 47 278425 1849 110308978
Therapy interrupted 65.18 12.31 22 278450 49800 110261027
Tumour hyperprogression 65.11 12.31 27 278445 339 110310488
Visual impairment 64.86 12.31 152 278320 134276 110176551
Electrolyte imbalance 64.73 12.31 223 278249 36805 110274022
Malignant transformation 64.72 12.31 43 278429 1482 110309345
Ascites 63.54 12.31 426 278046 92382 110218445
Joint injury 63.19 12.31 12 278460 39982 110270845
Metastases to adrenals 62.77 12.31 43 278429 1560 110309267
Chest discomfort 62.29 12.31 691 277781 173157 110137670
Superior vena cava syndrome 62.26 12.31 40 278432 1301 110309526
Procedural pain 62.24 12.31 8 278464 35557 110275270
Neutropenic infection 61.90 12.31 57 278415 3188 110307639
Head injury 61.74 12.31 16 278456 43001 110267826
Immune-mediated cytopenia 61.60 12.31 25 278447 296 110310531
Swollen tongue 61.34 12.31 38 278434 60324 110250503
Neutrophil count abnormal 61.19 12.31 70 278402 5062 110305765
Adrenal disorder 61.12 12.31 50 278422 2382 110308445
Lymphopenia 60.94 12.31 231 278241 39939 110270888
Renal failure 60.75 12.31 853 277619 225721 110085106
Bronchopleural fistula 60.60 12.31 34 278438 859 110309968
Disability 60.33 12.31 4 278468 30219 110280608
Anaphylactoid reaction 60.22 12.31 80 278392 6746 110304081
Sopor 59.84 12.31 10 278462 36536 110274291
Immune-mediated cystitis 59.38 12.31 20 278452 133 110310694
Agitation 59.35 12.31 122 278350 112929 110197898
Aggression 59.17 12.31 38 278434 59172 110251655
Hepatitis 59.06 12.31 409 278063 89645 110221182
Autoimmune hepatitis 58.76 12.31 121 278351 14683 110296144
Deafness 58.67 12.31 174 278298 26535 110284292
Dyskinesia 58.67 12.31 28 278444 51418 110259409
Tumour haemorrhage 58.29 12.31 69 278403 5176 110305651
Fanconi syndrome 57.96 12.31 57 278415 3462 110307365
Coma 57.90 12.31 132 278340 117737 110193090
Inappropriate schedule of product administration 57.58 12.31 290 278182 203347 110107480
Breast cancer metastatic 57.47 12.31 102 278370 11079 110299748
Breast cancer recurrent 57.30 12.31 59 278413 3787 110307040
Non-small cell lung cancer recurrent 56.85 12.31 21 278451 189 110310638
Enteritis 56.36 12.31 139 278333 19017 110291810
Haematochezia 56.24 12.31 130 278342 115394 110195433
Irritability 56.11 12.31 25 278447 47784 110263043
Extremity necrosis 56.06 12.31 58 278414 3744 110307083
Peripheral ischaemia 55.71 12.31 100 278372 10958 110299869
Tachycardia 55.52 12.31 840 277632 225805 110085022
Diffuse large B-cell lymphoma refractory 55.46 12.31 48 278424 2473 110308354
Labelled drug-drug interaction medication error 55.34 12.31 5 278467 29297 110281530
Colitis ulcerative 55.27 12.31 68 278404 77295 110233532
Wrong technique in product usage process 55.13 12.31 84 278388 87264 110223563
Emotional distress 54.96 12.31 22 278450 44825 110266002
Oesophagobronchial fistula 54.86 12.31 22 278450 252 110310575
Transaminases increased 54.77 12.31 309 278163 63081 110247746
Dysaesthesia 53.99 12.31 76 278396 6771 110304056
Respiratory tract congestion 53.86 12.31 7 278465 30850 110279977
Immune-mediated myositis 53.81 12.31 72 278400 6114 110304713
Hypoalbuminaemia 53.74 12.31 178 278294 28796 110282031
Skin reaction 53.53 12.31 145 278327 20999 110289828
Ear pain 53.41 12.31 34 278438 53192 110257635
Lupus-like syndrome 53.38 12.31 18 278454 40774 110270053
Liver function test increased 53.19 12.31 88 278384 88460 110222367
Hypoxia 53.08 12.31 529 277943 128986 110181841
Hyperthermia 52.98 12.31 145 278327 21127 110289700
Iris atrophy 52.73 12.31 20 278452 195 110310632
Gastric disorder 52.72 12.31 10 278462 33347 110277480
Withdrawal syndrome 52.70 12.31 8 278464 31372 110279455
Tumour associated fever 52.35 12.31 34 278438 1127 110309700
Pulmonary vascular disorder 52.34 12.31 33 278439 1038 110309789
Poisoning 52.28 12.31 6 278466 29099 110281728
Venous thrombosis 52.22 12.31 84 278388 8421 110302406
Throat tightness 51.98 12.31 194 278278 33295 110277532
Impaired quality of life 51.94 12.31 7 278465 30010 110280817
Encephalopathy 51.90 12.31 366 278106 80689 110230138
Pericarditis malignant 51.82 12.31 16 278456 77 110310750
Lymphadenopathy 51.78 12.31 306 278166 63529 110247298
Paronychia 51.77 12.31 97 278375 10984 110299843
Extrapyramidal disorder 51.73 12.31 6 278466 28861 110281966
Cancer pain 51.67 12.31 74 278398 6698 110304129
Hallucination, auditory 51.24 12.31 4 278468 26393 110284434
Walking aid user 51.01 12.31 3 278469 25072 110285755
Pneumatosis intestinalis 50.69 12.31 83 278389 8446 110302381
Optic glioma 50.62 12.31 15 278457 61 110310766
Autoimmune hypothyroidism 50.46 12.31 25 278447 486 110310341
Blood glucose increased 50.42 12.31 168 278304 132328 110178499
Lung adenocarcinoma 50.35 12.31 88 278384 9443 110301384
Paraneoplastic syndrome 50.20 12.31 35 278437 1307 110309520
Enterocolitis infectious 49.81 12.31 52 278420 3392 110307435
Poor venous access 49.68 12.31 3 278469 24519 110286308
Portal venous gas 49.50 12.31 25 278447 507 110310320
Endocarditis noninfective 49.25 12.31 21 278451 284 110310543
Foot fracture 49.22 12.31 4 278468 25542 110285285
Peripheral motor neuropathy 49.17 12.31 56 278416 4030 110306797
Pulmonary arteriopathy 49.04 12.31 16 278456 95 110310732
Eye pain 48.92 12.31 33 278439 50066 110260761
Abortion spontaneous 48.72 12.31 13 278459 34269 110276558
Cystitis haemorrhagic 48.70 12.31 100 278372 12109 110298718
Small intestinal obstruction 48.67 12.31 185 278287 32028 110278799
Blood lactate dehydrogenase increased 48.64 12.31 231 278241 44103 110266724
Hyperpyrexia 48.60 12.31 79 278393 7990 110302837
Endocrine toxicity 48.45 12.31 15 278457 73 110310754
Rectal perforation 48.31 12.31 31 278441 1006 110309821
Chronic sinusitis 48.13 12.31 4 278468 25080 110285747
Drug ineffective 48.09 12.31 3242 275230 1517298 108793529
Haemolytic uraemic syndrome 48.00 12.31 61 278411 4924 110305903
Autoimmune cholangitis 47.83 12.31 14 278458 54 110310773
Sinus disorder 47.30 12.31 12 278460 32716 110278111
Cancer fatigue 47.06 12.31 22 278450 374 110310453
Respiratory distress 47.06 12.31 316 278156 68558 110242269
Myeloid leukaemia 47.05 12.31 29 278443 876 110309951
Eye irritation 46.95 12.31 13 278459 33439 110277388
Viral infection 46.74 12.31 39 278433 53100 110257727
Hip arthroplasty 46.63 12.31 43 278429 55770 110255057
Hyperlipidaemia 46.60 12.31 16 278456 35832 110274995
Recurrent cancer 46.52 12.31 50 278422 3373 110307454
Balance disorder 46.30 12.31 145 278327 116415 110194412
Toxic epidermal necrolysis 46.06 12.31 272 278200 56455 110254372
Hallucination, visual 46.02 12.31 21 278451 39584 110271243
Swelling face 45.66 12.31 103 278369 92218 110218609
Nervousness 45.28 12.31 18 278454 36833 110273994
BRCA1 gene mutation 45.24 12.31 14 278458 68 110310759
Hiccups 45.10 12.31 100 278372 12769 110298058
Cortisol decreased 44.98 12.31 45 278427 2791 110308036
Autoimmune nephritis 44.97 12.31 27 278445 777 110310050
Lymphocyte count decreased 44.89 12.31 272 278200 56971 110253856
Small cell lung cancer 44.83 12.31 48 278424 3224 110307603
Acute megakaryocytic leukaemia 44.64 12.31 13 278459 49 110310778
Embolism venous 44.51 12.31 59 278413 4964 110305863
Sinus congestion 44.34 12.31 11 278461 30448 110280379
Systemic scleroderma 44.30 12.31 38 278434 1934 110308893
Cyanosis 44.27 12.31 170 278302 29571 110281256
Oedema 44.20 12.31 328 278144 209648 110101179
Alanine aminotransferase increased 44.18 12.31 679 277793 183094 110127733
Muscular weakness 44.17 12.31 406 278066 248062 110062765
Flatulence 43.78 12.31 40 278432 52109 110258718
Metastases to kidney 43.77 12.31 24 278448 579 110310248
Hypotension 43.71 12.31 1672 276800 522177 109788650
Eye pruritus 43.70 12.31 14 278458 32761 110278066
Onycholysis 43.63 12.31 44 278428 2755 110308072
Blood corticotrophin decreased 43.58 12.31 27 278445 823 110310004
International normalised ratio increased 43.57 12.31 96 278376 86676 110224151
Schizophrenia 43.24 12.31 3 278469 21823 110289004
Product storage error 43.01 12.31 3 278469 21725 110289102
Mental disorder 42.90 12.31 22 278450 38769 110272058
Product administration error 42.83 12.31 20 278452 37197 110273630
Pulmonary haemorrhage 42.82 12.31 114 278358 16342 110294485
Impaired work ability 41.59 12.31 8 278464 26411 110284416
Lichen planus 41.49 12.31 47 278425 3363 110307464
Hypervolaemia 41.45 12.31 38 278434 49422 110261405
Diabetes mellitus 41.35 12.31 121 278351 99260 110211567
Vision blurred 41.04 12.31 176 278296 128846 110181981
Immune-mediated endocrinopathy 41.00 12.31 15 278457 131 110310696
Tendonitis 40.84 12.31 8 278464 26075 110284752
Tracheal fistula 40.82 12.31 17 278455 216 110310611
Product substitution issue 40.81 12.31 5 278467 23056 110287771
Lung lobectomy 40.75 12.31 17 278455 217 110310610
BRCA2 gene mutation 40.47 12.31 14 278458 102 110310725
Obstructive airways disorder 40.43 12.31 34 278438 46115 110264712
Abdominal pain 40.37 12.31 1627 276845 511362 109799465
Lung abscess 40.07 12.31 56 278416 4956 110305871
Terminal agitation 39.89 12.31 8 278464 0 110310827
Retinitis pigmentosa 39.84 12.31 15 278457 143 110310684
Pain in jaw 39.79 12.31 42 278430 51135 110259692
Device dislocation 39.76 12.31 15 278457 31689 110279138
Cardiac murmur 39.75 12.31 7 278465 24621 110286206
Disturbance in attention 39.72 12.31 59 278413 61936 110248891
Cerebrovascular accident 39.69 12.31 280 278192 181004 110129823
Medulloblastoma recurrent 39.69 12.31 16 278456 186 110310641
Dermatitis atopic 39.65 12.31 8 278464 25533 110285294
Colitis ischaemic 39.34 12.31 116 278356 17634 110293193
Injection site rash 39.26 12.31 6 278466 23413 110287414
Retroperitoneal lymphadenopathy 39.23 12.31 31 278441 1405 110309422
Adrenocortical insufficiency acute 39.11 12.31 52 278420 4388 110306439
Transient ischaemic attack 38.97 12.31 63 278409 63919 110246908
Gastroenteritis viral 38.79 12.31 15 278457 31211 110279616
Metastases to spine 38.75 12.31 57 278415 5286 110305541
Metastases to spleen 38.75 12.31 25 278447 819 110310008
Ulcer 38.73 12.31 31 278441 43085 110267742
Myelitis 38.61 12.31 44 278428 3169 110307658
Drug eruption 38.36 12.31 249 278223 53410 110257417
Cytokine storm 38.22 12.31 31 278441 1459 110309368
Therapy cessation 38.14 12.31 34 278438 44823 110266004
Peritonitis 38.05 12.31 173 278299 32434 110278393
Hepatocellular injury 38.05 12.31 238 278234 50404 110260423
Limb injury 37.82 12.31 24 278448 37612 110273215
Dysstasia 37.54 12.31 18 278454 32968 110277859
Ulcer haemorrhage 37.35 12.31 6 278466 22565 110288262
Hip fracture 37.31 12.31 21 278451 35130 110275697
Sneezing 37.10 12.31 17 278455 31967 110278860
Coronary artery disease 37.09 12.31 78 278394 71612 110239215
Empyema 36.95 12.31 57 278415 5513 110305314
Skin disorder 36.95 12.31 209 278263 42704 110268123
Paranoia 36.91 12.31 6 278466 22368 110288459
Bacteraemia 36.86 12.31 207 278265 42183 110268644
Accidental exposure to product 36.73 12.31 43 278429 49965 110260862
Tumour cavitation 36.67 12.31 12 278460 72 110310755
Infectious pleural effusion 36.67 12.31 53 278419 4838 110305989
Bone pain 36.52 12.31 285 278187 64848 110245979
Ovarian cancer 36.46 12.31 50 278422 4346 110306481
Fatigue 36.46 12.31 2604 275868 1213354 109097473
Immune-mediated neurological disorder 36.40 12.31 12 278460 74 110310753
Device issue 36.13 12.31 21 278451 34514 110276313
Ovarian disorder 36.11 12.31 21 278451 569 110310258
Radiation necrosis 36.05 12.31 24 278448 830 110309997
Kidney infection 35.83 12.31 10 278462 25589 110285238
Mood swings 35.71 12.31 7 278465 22805 110288022
Seasonal allergy 35.59 12.31 4 278468 19718 110291109
Transplant rejection 35.52 12.31 9 278463 24558 110286269
Metastases to abdominal cavity 35.44 12.31 24 278448 854 110309973
Aplastic anaemia 35.41 12.31 138 278334 24170 110286657
Cervix carcinoma recurrent 35.28 12.31 11 278461 55 110310772
Axonal and demyelinating polyneuropathy 35.28 12.31 11 278461 55 110310772
Urosepsis 35.24 12.31 162 278310 30513 110280314
Capillary leak syndrome 35.08 12.31 52 278420 4856 110305971
Troponin increased 34.79 12.31 158 278314 29608 110281219
Lung disorder 34.74 12.31 288 278184 179759 110131068
Cholelithiasis 34.52 12.31 67 278405 63355 110247472
Fear 34.50 12.31 8 278464 23185 110287642
Tumour embolism 34.39 12.31 16 278456 269 110310558
Myelitis transverse 34.28 12.31 36 278436 2365 110308462
Skin haemorrhage 34.19 12.31 10 278462 24817 110286010
Oropharyngeal pain 34.17 12.31 200 278272 135076 110175751
Extravasation 34.15 12.31 51 278421 4794 110306033
Autoimmune dermatitis 34.08 12.31 15 278457 220 110310607
Bronchostenosis 34.01 12.31 24 278448 914 110309913
Left ventricular dysfunction 33.92 12.31 133 278339 23360 110287467
Abnormal behaviour 33.91 12.31 29 278443 39010 110271817
Miosis 33.88 12.31 7 278465 21976 110288851
Metastases to retroperitoneum 33.76 12.31 18 278454 410 110310417
Mastectomy 33.71 12.31 29 278443 1482 110309345
Upper limb fracture 33.58 12.31 6 278466 20882 110289945
Blood pressure diastolic increased 33.48 12.31 4 278468 18803 110292024
Haemoglobin decreased 33.27 12.31 841 277631 247886 110062941
Infected lymphocele 33.25 12.31 15 278457 234 110310593
Acute myelomonocytic leukaemia 33.18 12.31 18 278454 425 110310402
Pelvic abscess 33.10 12.31 37 278435 2609 110308218
Hypercreatininaemia 33.08 12.31 27 278445 1282 110309545
Drug level decreased 32.88 12.31 4 278468 18544 110292283
Injection site warmth 32.79 12.31 3 278469 17402 110293425
Cervix cancer metastatic 32.76 12.31 10 278462 46 110310781
Cachexia 32.74 12.31 89 278383 12916 110297911
Respiratory depression 32.72 12.31 20 278452 31981 110278846
Malaise 32.71 12.31 1371 277101 670448 109640379
Extraocular muscle disorder 32.69 12.31 18 278454 438 110310389
Metastases to muscle 32.66 12.31 17 278455 368 110310459
Panic attack 32.62 12.31 16 278456 28924 110281903
Gamma-glutamyltransferase increased 32.58 12.31 265 278207 61044 110249783
Eye disorder 32.55 12.31 16 278456 28890 110281937
Carbohydrate antigen 125 increased 32.52 12.31 36 278436 2511 110308316
Depressed mood 32.44 12.31 65 278407 60744 110250083
Crying 32.35 12.31 12 278460 25616 110285211
Anti-glomerular basement membrane disease 31.95 12.31 13 278459 155 110310672
Skin laceration 31.94 12.31 23 278449 33730 110277097
Laryngeal oedema 31.91 12.31 74 278398 9733 110301094
Drug use disorder 31.79 12.31 4 278468 18070 110292757
B-cell lymphoma recurrent 31.63 12.31 25 278447 1133 110309694
Emphysematous cystitis 31.61 12.31 20 278452 633 110310194
Ovarian epithelial cancer recurrent 31.48 12.31 8 278464 15 110310812
Prostate cancer 31.45 12.31 29 278443 37612 110273215
Peripheral sensorimotor neuropathy 31.44 12.31 44 278428 3899 110306928
Limb discomfort 31.24 12.31 34 278438 40820 110270007
Burning sensation 31.23 12.31 81 278391 69131 110241696
Blood urine present 31.20 12.31 11 278461 24234 110286593
Peritoneal neoplasm 31.19 12.31 12 278460 122 110310705
Madarosis 31.19 12.31 41 278431 3422 110307405
Cardiac tamponade 31.13 12.31 80 278392 11227 110299600
Optic atrophy 31.10 12.31 35 278437 2486 110308341
Gout 30.75 12.31 28 278444 36538 110274289
Embolism arterial 30.41 12.31 30 278442 1829 110308998
Meningitis 30.38 12.31 81 278391 11621 110299206
Acne 30.23 12.31 24 278448 33496 110277331
Delusion 30.19 12.31 11 278461 23744 110287083
Immunodeficiency 30.06 12.31 32 278440 38806 110272021
Fungating wound 30.01 12.31 10 278462 64 110310763
Gene mutation 29.96 12.31 40 278432 3389 110307438
Gallbladder disorder 29.84 12.31 8 278464 21021 110289806
Rectal haemorrhage 29.83 12.31 178 278294 119655 110191172
Femur fracture 29.79 12.31 41 278431 44428 110266399
Palpitations 29.67 12.31 257 278215 158955 110151872
Foetal death 29.60 12.31 3 278469 16042 110294785
Organising pneumonia 29.60 12.31 91 278381 14152 110296675
Joint effusion 29.57 12.31 8 278464 20897 110289930
Blood pressure diastolic decreased 29.56 12.31 28 278444 35857 110274970
Acquired amegakaryocytic thrombocytopenia 29.55 12.31 9 278463 41 110310786
Aortic wall hypertrophy 29.55 12.31 9 278463 41 110310786
Metabolic acidosis 29.36 12.31 140 278332 99604 110211223
Lung cancer metastatic 29.32 12.31 44 278428 4154 110306673
Malignant ascites 29.32 12.31 26 278446 1384 110309443
Myoclonus 29.29 12.31 24 278448 32974 110277853
Iron deficiency anaemia 29.22 12.31 22 278450 31537 110279290
Gastrointestinal haemorrhage 29.17 12.31 271 278201 165247 110145580
Cerebral infarction 29.16 12.31 227 278245 51611 110259216
Blood test abnormal 28.98 12.31 18 278454 28536 110282291
Delirium 28.85 12.31 210 278262 134815 110176012
Immune-mediated oesophagitis 28.77 12.31 10 278462 74 110310753
Pelvic infection 28.74 12.31 16 278456 398 110310429
Metastases to bladder 28.68 12.31 15 278457 328 110310499
Oropharyngeal squamous cell carcinoma 28.64 12.31 15 278457 329 110310498
Systemic infection 28.62 12.31 71 278401 9748 110301079
Affect lability 28.59 12.31 6 278466 18631 110292196
Polyneuropathy in malignant disease 28.48 12.31 17 278455 484 110310343
Hyperaemia 28.45 12.31 41 278431 3732 110307095
Oesophageal fistula 28.41 12.31 17 278455 486 110310341
Hypophagia 28.26 12.31 228 278244 52398 110258429
Oesophagopleural fistula 28.24 12.31 9 278463 49 110310778
Laboratory test abnormal 28.19 12.31 42 278430 44037 110266790
Skin candida 28.18 12.31 32 278440 2296 110308531
Eye swelling 28.16 12.31 25 278447 33023 110277804
Acoustic stimulation tests abnormal 28.16 12.31 8 278464 27 110310800
Platelet count abnormal 28.12 12.31 54 278418 6228 110304599
Normal newborn 28.07 12.31 10 278462 21886 110288941
Hypersomnia 28.05 12.31 18 278454 28043 110282784
Ischaemic stroke 27.99 12.31 189 278283 41074 110269753
Metastases to bone marrow 27.93 12.31 22 278450 992 110309835
Carpal tunnel syndrome 27.85 12.31 11 278461 22599 110288228
Laryngeal cancer stage III 27.72 12.31 8 278464 29 110310798
Hypothalamo-pituitary disorder 27.68 12.31 35 278437 2811 110308016
Epiglottic oedema 27.63 12.31 16 278456 430 110310397
Clostridium difficile colitis 27.62 12.31 197 278275 43581 110267246
Face oedema 27.50 12.31 161 278311 33308 110277519
Intervertebral disc degeneration 27.38 12.31 6 278466 18079 110292748
Anisometropia 27.37 12.31 10 278462 87 110310740
Hepatitis B reactivation 27.18 12.31 59 278413 7425 110303402
Axillary lymphadenectomy 27.17 12.31 10 278462 89 110310738
Arterioenteric fistula 27.10 12.31 8 278464 32 110310795
Mood altered 27.00 12.31 10 278462 21365 110289462
Pulmonary sepsis 26.93 12.31 48 278424 5230 110305597
Adverse reaction 26.93 12.31 21 278451 29573 110281254
Thrombocytosis 26.82 12.31 72 278400 10372 110300455
Eyelid ptosis 26.64 12.31 84 278388 13243 110297584
Nephrotic syndrome 26.57 12.31 86 278386 13745 110297082
Pyelonephritis 26.57 12.31 130 278342 25120 110285707
Hepatic lesion 26.45 12.31 63 278409 8430 110302397
Pancreatic toxicity 26.41 12.31 10 278462 97 110310730
Alopecia areata 26.36 12.31 30 278442 2157 110308670
Nervous system disorder 26.33 12.31 153 278319 31568 110279259
Obstructive shock 26.32 12.31 11 278461 141 110310686
Meningitis aseptic 26.31 12.31 69 278403 9801 110301026
Tumour invasion 26.16 12.31 17 278455 564 110310263
Lung squamous cell carcinoma metastatic 26.14 12.31 10 278462 100 110310727
Central vision loss 26.08 12.31 9 278463 65 110310762
Intervertebral disc protrusion 26.04 12.31 19 278453 27679 110283148
Ameloblastoma 25.88 12.31 10 278462 103 110310724
Histiocytic necrotising lymphadenitis 25.85 12.31 9 278463 67 110310760
Retinopathy proliferative 25.85 12.31 11 278461 148 110310679
Laryngospasm 25.84 12.31 44 278428 4624 110306203
Metastases to the mediastinum 25.80 12.31 19 278453 774 110310053
Aspartate aminotransferase increased 25.76 12.31 555 277917 159381 110151446
Laryngeal necrosis 25.66 12.31 8 278464 40 110310787
Rhabdomyosarcoma recurrent 25.65 12.31 11 278461 151 110310676
IIIrd nerve paralysis 25.60 12.31 24 278448 1373 110309454
Endometrial cancer recurrent 25.51 12.31 7 278465 20 110310807
Tenderness 25.41 12.31 22 278450 29415 110281412
Pseudocirrhosis 25.37 12.31 20 278452 903 110309924
Hypoproteinaemia 25.27 12.31 50 278422 5895 110304932
Duodenal perforation 25.26 12.31 33 278439 2737 110308090
Purpura 25.26 12.31 125 278347 24263 110286564
Glycosylated haemoglobin increased 25.23 12.31 14 278458 23605 110287222
Laryngopharyngitis 25.14 12.31 10 278462 112 110310715
Thinking abnormal 25.11 12.31 4 278468 15136 110295691
Autoimmune lung disease 25.10 12.31 12 278460 215 110310612
Scleroderma-like reaction 25.05 12.31 12 278460 216 110310611
Ligament sprain 25.01 12.31 5 278467 16063 110294764
Cystoid macular oedema 24.98 12.31 33 278439 2767 110308060
Peptic ulcer perforation 24.97 12.31 19 278453 814 110310013
Bone density decreased 24.95 12.31 5 278467 16037 110294790
Haemoglobin abnormal 24.93 12.31 64 278408 8974 110301853
Gastrointestinal necrosis 24.87 12.31 53 278419 6587 110304240
Cardiac dysfunction 24.86 12.31 51 278421 6172 110304655
Rib fracture 24.84 12.31 29 278443 33741 110277086
Musculoskeletal disorder 24.84 12.31 13 278459 22651 110288176
Pulmonary fistula 24.75 12.31 10 278462 117 110310710
Aortic thrombosis 24.73 12.31 29 278443 2154 110308673
Hypokinesia 24.70 12.31 12 278460 21814 110289013
Oral fungal infection 24.69 12.31 42 278430 4410 110306417
Rotator cuff syndrome 24.57 12.31 6 278466 16788 110294039
Oligoastrocytoma 24.55 12.31 7 278465 24 110310803
Paraneoplastic dermatomyositis 24.42 12.31 12 278460 229 110310598
Acquired tracheo-oesophageal fistula 24.42 12.31 11 278461 171 110310656
Macular degeneration 24.37 12.31 12 278460 21647 110289180
Iris neovascularisation 24.36 12.31 9 278463 81 110310746
Splenic artery thrombosis 24.36 12.31 9 278463 81 110310746
Anastomotic leak 24.35 12.31 23 278449 1329 110309498
Acute erythroid leukaemia 24.28 12.31 14 278458 373 110310454
Leukoencephalopathy 24.23 12.31 64 278408 9131 110301696
Faeces discoloured 24.08 12.31 30 278442 33918 110276909
Pneumonia bacterial 24.01 12.31 130 278342 26131 110284696
Benign prostatic hyperplasia 23.94 12.31 8 278464 18226 110292601
Retinal toxicity 23.91 12.31 25 278447 1634 110309193
Radiation mucositis 23.84 12.31 13 278459 310 110310517
Epilepsy 23.82 12.31 151 278321 100058 110210769
Photophobia 23.82 12.31 18 278454 25753 110285074
Head discomfort 23.81 12.31 9 278463 18991 110291836
Blood creatinine increased 23.75 12.31 616 277856 182273 110128554
Hyperphosphaturia 23.74 12.31 10 278462 131 110310696
Lymphadenectomy 23.68 12.31 24 278448 1512 110309315
Dermatitis exfoliative generalised 23.64 12.31 71 278401 10901 110299926
Respiratory syncytial virus infection 23.63 12.31 4 278468 14480 110296347
Product dispensing error 23.61 12.31 6 278466 16339 110294488
Dementia 23.52 12.31 27 278445 31646 110279181
Radiation injury 23.48 12.31 20 278452 1008 110309819
Breast cancer 23.43 12.31 38 278434 38504 110272323
Pulmonary resection 23.43 12.31 11 278461 189 110310638
Troponin abnormal 23.40 12.31 10 278462 136 110310691
Deafness neurosensory 23.39 12.31 65 278407 9554 110301273
Hiatus hernia 23.38 12.31 21 278451 27585 110283242
Eczema 23.37 12.31 98 278374 72195 110238632
Fixed bowel loop 23.36 12.31 6 278466 12 110310815
Vaginal discharge 23.26 12.31 8 278464 17900 110292927
Venous thrombosis limb 23.25 12.31 45 278427 5220 110305607
Pulmonary oedema 23.25 12.31 153 278319 100506 110210321
Carcinoembryonic antigen increased 23.24 12.31 32 278440 2792 110308035
Emotional disorder 23.21 12.31 6 278466 16154 110294673
Liver function test abnormal 23.21 12.31 92 278380 68858 110241969
Pharyngitis streptococcal 23.20 12.31 3 278469 13274 110297553
Blood glucose decreased 23.15 12.31 24 278448 29464 110281363
Sinus bradycardia 23.14 12.31 24 278448 29459 110281368
Large intestine infection 23.11 12.31 41 278431 4451 110306376
Skin cancer 23.01 12.31 8 278464 17776 110293051
Seronegative arthritis 22.97 12.31 3 278469 13174 110297653
Peritoneal disorder 22.93 12.31 18 278454 808 110310019
Jugular vein thrombosis 22.78 12.31 45 278427 5300 110305527
Pathogen resistance 22.77 12.31 8 278464 17664 110293163
Chromosomal mutation 22.70 12.31 8 278464 62 110310765
Skin ulcer 22.66 12.31 83 278389 63562 110247265
Metaplasia 22.63 12.31 16 278456 611 110310216
Small cell carcinoma 22.63 12.31 13 278459 344 110310483
Radiation dysphagia 22.59 12.31 5 278467 3 110310824
Intestinal obstruction 22.57 12.31 219 278253 53008 110257819
Immune-mediated uveitis 22.56 12.31 12 278460 272 110310555
Hypertensive crisis 22.52 12.31 121 278351 24251 110286576
Arteriosclerotic retinopathy 22.45 12.31 7 278465 35 110310792
Demyelinating polyneuropathy 22.41 12.31 28 278444 2221 110308606
Immune-mediated neuropathy 22.38 12.31 11 278461 210 110310617
Neuroblastoma recurrent 22.37 12.31 15 278457 525 110310302
Eosinophilia 22.35 12.31 73 278399 57863 110252964
Squamous cell carcinoma of lung 22.31 12.31 31 278441 2728 110308099
Cold sweat 22.17 12.31 112 278360 21919 110288908
Noninfectious myelitis 22.17 12.31 6 278466 16 110310811
Surgery 22.13 12.31 44 278428 41239 110269588
Escherichia bacteraemia 22.12 12.31 66 278406 10098 110300729
Scleroedema 22.11 12.31 10 278462 157 110310670
Alopecia 22.05 12.31 725 277747 364028 109946799
Shock 22.00 12.31 219 278253 53369 110257458
Brachydactyly 21.98 12.31 7 278465 38 110310789
Vaginal fistula 21.94 12.31 13 278459 365 110310462
Acute polyneuropathy 21.89 12.31 17 278455 751 110310076
Poor quality sleep 21.88 12.31 23 278449 28054 110282773
Dysgeusia 21.87 12.31 271 278201 69714 110241113
Blood calcium increased 21.86 12.31 9 278463 18031 110292796
Ocular hyperaemia 21.82 12.31 41 278431 39245 110271582
Muscle twitching 21.71 12.31 26 278446 29909 110280918
Glomerular vascular disorder 21.65 12.31 11 278461 226 110310601
Carbamoyl phosphate synthetase deficiency 21.65 12.31 6 278466 18 110310809
Angioedema 21.62 12.31 152 278320 98348 110212479
Thirst 21.59 12.31 14 278458 21693 110289134
Eye excision 21.56 12.31 8 278464 73 110310754
Chylothorax 21.46 12.31 20 278452 1136 110309691
Facial pain 21.45 12.31 6 278466 15333 110295494
Hepatic steatosis 21.39 12.31 58 278414 48773 110262054
Pulmonary cavitation 21.36 12.31 27 278445 2167 110308660
Haemorrhage 21.34 12.31 169 278303 106523 110204304
Mania 21.26 12.31 13 278459 20783 110290044
Subdural haematoma 21.18 12.31 37 278435 36417 110274410
Transfusion-associated dyspnoea 21.09 12.31 8 278464 78 110310749
High grade B-cell lymphoma Burkitt-like lymphoma recurrent 21.00 12.31 8 278464 79 110310748
Dyslipidaemia 20.97 12.31 7 278465 15958 110294869
Cardiogenic shock 20.93 12.31 74 278398 57264 110253563
Monocyte count decreased 20.92 12.31 36 278436 3815 110307012
Autoimmune neutropenia 20.83 12.31 16 278456 695 110310132
Fracture 20.82 12.31 19 278453 24769 110286058
Upper-airway cough syndrome 20.74 12.31 7 278465 15850 110294977
Muscle rigidity 20.69 12.31 18 278454 24013 110286814
Increased appetite 20.69 12.31 6 278466 14971 110295856
Extra dose administered 20.65 12.31 3 278469 12156 110298671
Acute monocytic leukaemia 20.63 12.31 15 278457 599 110310228
Depressed level of consciousness 20.58 12.31 182 278290 112096 110198731
Drug tolerance 20.54 12.31 8 278464 16577 110294250
Morphoea 20.54 12.31 15 278457 603 110310224
Pollakiuria 20.50 12.31 51 278421 44144 110266683
Osteosarcoma 20.42 12.31 13 278459 416 110310411
Gliosis 20.42 12.31 16 278456 716 110310111
Renal cancer 20.40 12.31 4 278468 13030 110297797
Oedema peripheral 20.40 12.31 651 277821 328009 109982818
Dysarthria 20.38 12.31 126 278346 83995 110226832
Dry eye 20.37 12.31 72 278400 55721 110255106
Paraneoplastic rash 20.32 12.31 8 278464 87 110310740
Ovarian failure 20.30 12.31 18 278454 958 110309869
Blast cells present 20.27 12.31 18 278454 960 110309867
Infection 20.25 12.31 727 277745 361473 109949354
Pleurocutaneous fistula 20.23 12.31 7 278465 51 110310776
Arteriosclerosis coronary artery 20.23 12.31 20 278452 25098 110285729
Secretion discharge 20.22 12.31 13 278459 20231 110290596
Heavy menstrual bleeding 20.10 12.31 8 278464 16357 110294470
Encephalitis enteroviral 20 12.31 11 278461 267 110310560
Aorto-oesophageal fistula 20.00 12.31 8 278464 91 110310736
Heat cramps 19.95 12.31 4 278468 0 110310827
Temperature regulation disorder 19.94 12.31 4 278468 12822 110298005
Immune-mediated encephalopathy 19.92 12.31 8 278464 92 110310735
Delayed puberty 19.84 12.31 10 278462 202 110310625
Vitreous haemorrhage 19.81 12.31 39 278433 4581 110306246
Chromosome analysis abnormal 19.74 12.31 11 278461 274 110310553
Increased tendency to bruise 19.74 12.31 3 278469 11755 110299072
Neuroblastoma 19.72 12.31 12 278460 354 110310473
Blood thyroid stimulating hormone increased 19.71 12.31 72 278400 12229 110298598
Rash pustular 19.64 12.31 74 278398 12755 110298072
Febrile infection 19.62 12.31 38 278434 4410 110306417
Optic neuropathy 19.59 12.31 39 278433 4619 110306208
Immune-mediated cholestasis 19.56 12.31 7 278465 57 110310770
Hot flush 19.48 12.31 253 278219 65783 110245044
Device leakage 19.46 12.31 8 278464 16040 110294787
Metastases to breast 19.45 12.31 12 278460 363 110310464
Vena cava thrombosis 19.42 12.31 33 278439 3461 110307366
Autoimmune thyroiditis 19.26 12.31 47 278425 6387 110304440
Body temperature decreased 19.26 12.31 40 278432 36895 110273932
Pancreatitis 19.25 12.31 147 278325 93386 110217441
B-cell type acute leukaemia 19.22 12.31 21 278451 1443 110309384
Therapeutic response unexpected 19.18 12.31 19 278453 23824 110287003
Anosmia 19.16 12.31 4 278468 12468 110298359
Scintillating scotoma 19.11 12.31 10 278462 219 110310608
Gastropleural fistula 19.05 12.31 7 278465 62 110310765
Urinary tract obstruction 19.02 12.31 41 278431 5136 110305691
Lymphocytic hypophysitis 19.02 12.31 15 278457 678 110310149
Synovial cyst 19.00 12.31 3 278469 11427 110299400
Bladder perforation 18.91 12.31 12 278460 382 110310445
Odynophagia 18.89 12.31 78 278394 14023 110296804
Respiratory arrest 18.86 12.31 79 278393 58220 110252607
Band sensation 18.77 12.31 18 278454 1060 110309767
Chills 18.75 12.31 620 277852 189960 110120867
Adenocarcinoma metastatic 18.74 12.31 12 278460 388 110310439
Administration related reaction 18.72 12.31 11 278461 304 110310523
Pancreatic carcinoma 18.71 12.31 7 278465 14865 110295962
Blood thyroid stimulating hormone decreased 18.68 12.31 50 278422 7189 110303638
Infantile vomiting 18.66 12.31 7 278465 66 110310761
Bronchiectasis 18.63 12.31 40 278432 36453 110274374
Ureteric fistula 18.62 12.31 6 278466 34 110310793
Rhinitis allergic 18.60 12.31 11 278461 17911 110292916
Liver scan abnormal 18.57 12.31 7 278465 67 110310760
Vaginal cuff dehiscence 18.56 12.31 5 278467 13 110310814
Faeces soft 18.50 12.31 3 278469 11207 110299620
Movement disorder 18.50 12.31 40 278432 36364 110274463
Pain of skin 18.49 12.31 14 278458 20015 110290812
Akathisia 18.49 12.31 10 278462 17103 110293724
Sputum discoloured 18.49 12.31 26 278446 27919 110282908
Ovarian cyst 18.48 12.31 6 278466 13924 110296903
Periarticular thenar erythema with onycholysis 18.48 12.31 7 278465 68 110310759
Adenocarcinoma of the cervix 18.40 12.31 10 278462 237 110310590
Optic disc haemorrhage 18.40 12.31 10 278462 237 110310590
Neutrophil toxic granulation present 18.36 12.31 10 278462 238 110310589
Hypertension 18.34 12.31 1074 277398 509010 109801817
Right ventricular failure 18.34 12.31 23 278449 25931 110284896
Basal cell naevus syndrome 18.34 12.31 6 278466 36 110310791
Scratch 18.30 12.31 5 278467 12974 110297853
Metastases to pelvis 18.29 12.31 16 278456 836 110309991
Laryngeal pain 18.26 12.31 44 278428 5931 110304896
Cellulitis 18.26 12.31 216 278256 125800 110185027
Back pain 18.25 12.31 756 277716 370240 109940587
Ankle fracture 18.11 12.31 14 278458 19805 110291022
Double hit lymphoma 18.06 12.31 6 278466 38 110310789
Arterial thrombosis 18.06 12.31 30 278442 3089 110307738
Metastases to pancreas 18.06 12.31 15 278457 730 110310097
Cellulitis gangrenous 18.05 12.31 12 278460 414 110310413
Bone marrow infiltration 18.04 12.31 16 278456 852 110309975
Metastases to eye 18.00 12.31 11 278461 327 110310500
Pharyngitis 17.99 12.31 22 278450 25076 110285751
Type IV hypersensitivity reaction 17.99 12.31 44 278428 5989 110304838
Spinal operation 17.97 12.31 3 278469 10969 110299858
Mechanical ileus 17.97 12.31 19 278453 1258 110309569
Hand dermatitis 17.96 12.31 15 278457 736 110310091
Device related infection 17.96 12.31 165 278307 39354 110271473
Oesophageal stenosis 17.95 12.31 40 278432 5125 110305702
Malignant peritoneal neoplasm 17.92 12.31 15 278457 738 110310089
Neoplasm 17.85 12.31 65 278407 11022 110299805
Dry skin 17.81 12.31 179 278293 107474 110203353
Choroidal dystrophy 17.80 12.31 6 278466 40 110310787
Breast tumour excision 17.80 12.31 5 278467 16 110310811
Mixed deafness 17.80 12.31 5 278467 16 110310811
Amoebic colitis 17.78 12.31 8 278464 124 110310703
Oxygen therapy 17.74 12.31 35 278437 4118 110306709
Psychomotor hyperactivity 17.69 12.31 15 278457 20262 110290565
Autoimmune myocarditis 17.67 12.31 14 278458 637 110310190
Eye haemorrhage 17.64 12.31 4 278468 11770 110299057
Klebsiella test positive 17.60 12.31 26 278446 2420 110308407
Atrial flutter 17.59 12.31 113 278359 24149 110286678
Blood phosphorus abnormal 17.59 12.31 11 278461 341 110310486
Adjustment disorder 17.57 12.31 3 278469 10792 110300035
Lipoprotein increased 17.57 12.31 5 278467 17 110310810
Granulocytopenia 17.57 12.31 71 278401 12644 110298183
Pulmonary sarcoidosis 17.56 12.31 22 278450 1750 110309077
Listeriosis 17.56 12.31 28 278444 2786 110308041
COVID-19 17.56 12.31 476 277996 244584 110066243
Barotrauma 17.54 12.31 9 278463 189 110310638
Tooth infection 17.53 12.31 18 278454 22198 110288629
Cytotoxic oedema 17.48 12.31 12 278460 437 110310390
BRAF V600E mutation positive 17.47 12.31 7 278465 80 110310747
Miller Fisher syndrome 17.45 12.31 11 278461 346 110310481
Kounis syndrome 17.44 12.31 43 278429 5882 110304945
Hypersensitivity pneumonitis 17.43 12.31 40 278432 5225 110305602
Blood loss anaemia 17.43 12.31 12 278460 18013 110292814
Laryngeal discomfort 17.41 12.31 15 278457 768 110310059
Clinomania 17.39 12.31 7 278465 81 110310746
Carcinoid crisis 17.39 12.31 13 278459 542 110310285
Potentiating drug interaction 17.35 12.31 4 278468 11639 110299188
Oesophagomediastinal fistula 17.35 12.31 5 278467 18 110310809
Haemoglobin 17.28 12.31 8 278464 133 110310694
PIK3CA-activated mutation 17.26 12.31 14 278458 659 110310168
Pelvic fracture 17.25 12.31 7 278465 14147 110296680
Respiratory symptom 17.25 12.31 8 278464 14937 110295890
Haemoglobinaemia 17.20 12.31 11 278461 355 110310472
Omentectomy 17.19 12.31 6 278466 45 110310782
Oral papule 17.19 12.31 4 278468 4 110310823
Confluent and reticulate papillomatosis 17.19 12.31 4 278468 4 110310823
Gastrin-releasing peptide precursor increased 17.19 12.31 4 278468 4 110310823
Lip oedema 17.16 12.31 50 278422 7550 110303277
White blood cell count abnormal 17.11 12.31 47 278425 6862 110303965
Tooth disorder 17.10 12.31 30 278442 29479 110281348
Dystonia 17.08 12.31 24 278448 25781 110285046
Henoch-Schonlein purpura 17.07 12.31 32 278440 3625 110307202
Congestive cardiomyopathy 17.01 12.31 76 278396 14143 110296684
Gastroenteritis radiation 17.00 12.31 15 278457 793 110310034
Peritonitis bacterial 16.99 12.31 3 278469 10530 110300297
Streptococcal endocarditis 16.96 12.31 10 278462 278 110310549
Metastases to abdominal wall 16.96 12.31 9 278463 203 110310624
Glaucoma 16.93 12.31 19 278453 22498 110288329
Tooth fracture 16.90 12.31 6 278466 13161 110297666
Taste disorder 16.87 12.31 96 278376 65291 110245536
Growth hormone deficiency 16.82 12.31 12 278460 465 110310362
Diarrhoea haemorrhagic 16.80 12.31 81 278391 15558 110295269
Thrombocytopenia neonatal 16.74 12.31 5 278467 21 110310806
Aortic stenosis 16.68 12.31 6 278466 13053 110297774
Burkholderia pseudomallei infection 16.65 12.31 8 278464 145 110310682
Skin hyperpigmentation 16.64 12.31 54 278418 8642 110302185
Blood potassium increased 16.51 12.31 37 278435 33212 110277615
Hair texture abnormal 16.50 12.31 33 278439 3921 110306906
Erythrosis 16.46 12.31 9 278463 216 110310611
Oesophageal candidiasis 16.41 12.31 65 278407 11469 110299358
Drug dose omission by device 16.40 12.31 8 278464 14508 110296319
Osteomyelitis 16.39 12.31 43 278429 36557 110274270
Parkinsonism 16.38 12.31 19 278453 22168 110288659
Enterocolitis haemorrhagic 16.37 12.31 26 278446 2578 110308249
Heart rate increased 16.35 12.31 259 278213 143575 110167252
Vascular access site swelling 16.30 12.31 4 278468 6 110310821
Anaphylactoid shock 16.29 12.31 16 278456 970 110309857
Hypomania 16.27 12.31 3 278469 10207 110300620
Thrombotic thrombocytopenic purpura 16.26 12.31 47 278425 7064 110303763
Nerve compression 16.26 12.31 4 278468 11133 110299694
Cerebral ischaemia 16.26 12.31 67 278405 12037 110298790
Kidney transplant rejection 16.20 12.31 5 278467 11982 110298845
Orthostatic hypotension 16.17 12.31 99 278373 66150 110244677
Abnormal dreams 16.11 12.31 6 278466 12774 110298053
Speech disorder 16.10 12.31 90 278382 61479 110249348
Large intestine polyp 16.09 12.31 9 278463 15108 110295719
TP53 gene mutation 16.08 12.31 8 278464 157 110310670
Solid organ transplant rejection 16.05 12.31 6 278466 56 110310771
Biliary dilatation 16.03 12.31 31 278441 3594 110307233
Hyperbilirubinaemia 15.99 12.31 132 278340 30539 110280288
Anorectal malformation 15.96 12.31 6 278466 57 110310770
Respiratory rate increased 15.94 12.31 24 278448 25059 110285768
Cyst 15.92 12.31 11 278461 16485 110294342
Circulatory collapse 15.90 12.31 172 278300 42821 110268006
Postoperative wound infection 15.89 12.31 10 278462 15743 110295084
Hair colour changes 15.88 12.31 36 278436 4665 110306162
Catheter site thrombosis 15.86 12.31 13 278459 621 110310206
Adenocarcinoma 15.84 12.31 34 278438 4246 110306581
Bacterial tracheitis 15.76 12.31 7 278465 105 110310722
Fungal infection 15.73 12.31 70 278402 50736 110260091
Eyelid oedema 15.65 12.31 78 278394 15184 110295643
Tenosynovitis 15.53 12.31 11 278461 16272 110294555
Nocturia 15.53 12.31 12 278460 16978 110293849
Breast conserving surgery 15.52 12.31 15 278457 892 110309935
Lymph node abscess 15.51 12.31 6 278466 62 110310765
Musculoskeletal discomfort 15.47 12.31 22 278450 23516 110287311
Ventricular tachycardia 15.42 12.31 69 278403 49940 110260887
Hypotensive crisis 15.42 12.31 8 278464 172 110310655
Intestinal ischaemia 15.41 12.31 81 278391 16098 110294729
Bladder cancer 15.39 12.31 17 278455 20275 110290552
Scar 15.33 12.31 12 278460 16869 110293958
Myxoedema 15.27 12.31 9 278463 250 110310577
Right ventricular ejection fraction decreased 15.26 12.31 6 278466 65 110310762
Metastases to gastrointestinal tract 15.25 12.31 8 278464 176 110310651
Neuroendocrine tumour of the lung metastatic 15.25 12.31 8 278464 176 110310651
Transformation to acute myeloid leukaemia 15.24 12.31 19 278453 1504 110309323
Gas gangrene 15.22 12.31 10 278462 338 110310489
Glomerulonephritis rapidly progressive 15.16 12.31 23 278449 2192 110308635
Hernia 15.16 12.31 16 278456 19484 110291343
Mediastinum neoplasm 15.14 12.31 7 278465 116 110310711
Aortic dissection rupture 15.10 12.31 6 278466 67 110310760
Retinopathy 15.05 12.31 34 278438 4395 110306432
Osteonecrosis of jaw 15.03 12.31 186 278286 47831 110262996
Lip swelling 14.98 12.31 71 278401 50596 110260231
Radiation neuropathy 14.96 12.31 4 278468 10 110310817
Carotid artery occlusion 14.84 12.31 3 278469 9562 110301265
Pulmonary hypertension 14.83 12.31 80 278392 55140 110255687
Myeloproliferative neoplasm 14.82 12.31 18 278454 1387 110309440
Eczema asteatotic 14.80 12.31 14 278458 810 110310017
Hormone receptor positive breast cancer 14.79 12.31 12 278460 565 110310262
Pyopneumothorax 14.79 12.31 6 278466 71 110310756
Breast necrosis 14.77 12.31 7 278465 123 110310704
Ulcerative duodenitis 14.75 12.31 5 278467 34 110310793
Syringe issue 14.75 12.31 3 278469 9522 110301305
Cancer with a high tumour mutational burden 14.75 12.31 5 278467 34 110310793
Epiglottitis 14.73 12.31 15 278457 950 110309877
Chronic obstructive pulmonary disease 14.72 12.31 190 278282 108968 110201859
Escherichia sepsis 14.70 12.31 58 278414 10214 110300613
Paraneoplastic retinopathy 14.69 12.31 4 278468 11 110310816
Bronchogram abnormal 14.69 12.31 4 278468 11 110310816
Cytokine abnormal 14.69 12.31 4 278468 11 110310816
Vaginal perforation 14.69 12.31 4 278468 11 110310816
HTLV-1 test positive 14.69 12.31 4 278468 11 110310816
Aortic injury 14.69 12.31 4 278468 11 110310816
Cognitive disorder 14.68 12.31 145 278327 87366 110223461
Cytomegalovirus enterocolitis 14.65 12.31 23 278449 2258 110308569
Urethral fistula 14.63 12.31 5 278467 35 110310792
Diabetes insipidus 14.62 12.31 43 278429 6527 110304300
Coronary artery occlusion 14.59 12.31 11 278461 15761 110295066
Jaw operation 14.52 12.31 14 278458 830 110309997
Spinal cord injury cervical 14.52 12.31 8 278464 195 110310632
VIth nerve paralysis 14.51 12.31 20 278452 1747 110309080
Dental caries 14.49 12.31 7 278465 12766 110298061
Bone lesion 14.47 12.31 45 278427 7042 110303785
Adenosquamous cell lung cancer stage IV 14.43 12.31 4 278468 12 110310815
White blood cell count increased 14.41 12.31 165 278307 96677 110214150
Food protein-induced enterocolitis syndrome 14.39 12.31 5 278467 37 110310790
Hydrocephalus 14.39 12.31 58 278414 10317 110300510
Failure to thrive 14.36 12.31 70 278402 13504 110297323
Skin discolouration 14.34 12.31 69 278403 48977 110261850
Anaemia of malignant disease 14.34 12.31 15 278457 981 110309846
Opsoclonus myoclonus 14.34 12.31 9 278463 281 110310546
Paratracheal lymphadenopathy 14.33 12.31 8 278464 200 110310627
Coordination abnormal 14.30 12.31 26 278446 25202 110285625
Optic ischaemic neuropathy 14.28 12.31 32 278440 4115 110306712
Therapeutic product effect incomplete 14.20 12.31 442 278030 223363 110087464
Peritoneal lesion 14.19 12.31 4 278468 13 110310814
Injection site extravasation 14.18 12.31 4 278468 10165 110300662
Full blood count decreased 14.15 12.31 38 278434 32061 110278766
Positron emission tomogram abnormal 14.14 12.31 11 278461 487 110310340
Clostridium bacteraemia 14.14 12.31 11 278461 487 110310340
Pneumothorax spontaneous 14.08 12.31 20 278452 1797 110309030
Eructation 14.07 12.31 9 278463 14048 110296779
Shock symptom 14.06 12.31 11 278461 491 110310336
Wrong product administered 14.06 12.31 5 278467 10955 110299872
Mixed liver injury 14.03 12.31 64 278408 12015 110298812
Eating disorder 14.01 12.31 36 278436 30822 110280005
Hypermetabolism 13.98 12.31 12 278460 611 110310216
Ventricular fibrillation 13.98 12.31 55 278417 41258 110269569
Roseolovirus test positive 13.97 12.31 9 278463 294 110310533
Eye inflammation 13.97 12.31 3 278469 9168 110301659
Feeling jittery 13.97 12.31 10 278462 14712 110296115
Autoimmune retinopathy 13.94 12.31 5 278467 41 110310786
Uterine adhesions 13.94 12.31 5 278467 41 110310786
Cushingoid 13.94 12.31 6 278466 11706 110299121
Cellulitis orbital 13.92 12.31 15 278457 1015 110309812
Glioma 13.92 12.31 14 278458 874 110309953
Breast cancer female 13.89 12.31 7 278465 12461 110298366
Product preparation error 13.89 12.31 5 278467 10874 110299953
Colorectal cancer 13.85 12.31 3 278469 9111 110301716
Premature menopause 13.78 12.31 15 278457 1027 110309800
Cardiomyopathy 13.76 12.31 137 278335 33388 110277439
Oophorectomy bilateral 13.76 12.31 6 278466 86 110310741
Radiotherapy to mediastinum 13.75 12.31 4 278468 15 110310812
Endometrial cancer metastatic 13.73 12.31 5 278467 43 110310784
Candida test positive 13.71 12.31 17 278455 1338 110309489
Hypochloraemia 13.69 12.31 29 278443 3589 110307238
Metastases to stomach 13.68 12.31 9 278463 305 110310522
Acute febrile neutrophilic dermatosis 13.67 12.31 35 278437 4901 110305926
Activated partial thromboplastin time prolonged 13.65 12.31 22 278450 22346 110288481
Pulmonary fibrosis 13.62 12.31 178 278294 101864 110208963
Eye infection 13.60 12.31 10 278462 14508 110296319
Hepatic failure 13.57 12.31 246 278226 68493 110242334
Adenocarcinoma of appendix 13.57 12.31 6 278466 89 110310738
Clostridial sepsis 13.55 12.31 15 278457 1046 110309781
Radiotherapy to lymph nodes 13.55 12.31 4 278468 16 110310811
Nerve injury 13.55 12.31 5 278467 10708 110300119
Postictal state 13.46 12.31 23 278449 2423 110308404
Tachypnoea 13.38 12.31 155 278317 39240 110271587
Metastases to vagina 13.36 12.31 4 278468 17 110310810
Insurance issue 13.34 12.31 5 278467 10607 110300220
Mydriasis 13.32 12.31 22 278450 22135 110288692
Diabetes mellitus inadequate control 13.32 12.31 35 278437 29740 110281087
Rheumatoid nodule 13.31 12.31 19 278453 20277 110290550
Weight fluctuation 13.30 12.31 22 278450 22123 110288704
Adenomatous polyposis coli 13.27 12.31 9 278463 321 110310506
Metastases to heart 13.27 12.31 10 278462 422 110310405
Lymphangitis 13.22 12.31 18 278454 1554 110309273
Cardiomegaly 13.21 12.31 34 278438 29096 110281731
Intestinal metastasis 13.20 12.31 11 278461 538 110310289
Atelectasis 13.17 12.31 146 278326 36566 110274261
Engraftment syndrome 13.14 12.31 20 278452 1912 110308915
Seroma 13.12 12.31 27 278445 3274 110307553
Appendicitis 13.08 12.31 33 278439 28431 110282396
Herpes zoster 13.06 12.31 193 278279 108186 110202641
Ear discomfort 13.02 12.31 6 278466 11243 110299584
Nephrostomy 12.98 12.31 9 278463 333 110310494
Cell death 12.98 12.31 38 278434 5753 110305074
Leukonychia 12.94 12.31 6 278466 100 110310727
Oesophagitis ulcerative 12.93 12.31 18 278454 1587 110309240
Hallucinations, mixed 12.93 12.31 3 278469 8690 110302137
Nail disorder 12.91 12.31 89 278383 57846 110252981
Prohormone brain natriuretic peptide abnormal 12.89 12.31 3 278469 3 110310824
Therapy responder 12.87 12.31 10 278462 442 110310385
Gastrointestinal mucosal disorder 12.86 12.31 16 278456 1264 110309563
Thymus enlargement 12.84 12.31 7 278465 167 110310660
Bradypnoea 12.83 12.31 3 278469 8646 110302181
Anti-platelet antibody positive 12.79 12.31 9 278463 341 110310486
Blood thyroid stimulating hormone abnormal 12.79 12.31 15 278457 1114 110309713
Abdominal abscess 12.79 12.31 50 278422 8769 110302058
Autoimmune pericarditis 12.78 12.31 6 278466 103 110310724
Pancreatic failure 12.78 12.31 22 278450 2332 110308495
Restlessness 12.75 12.31 86 278386 56173 110254654
Hyperreflexia 12.74 12.31 4 278468 9481 110301346
Gastritis bacterial 12.74 12.31 11 278461 565 110310262
Pneumonectomy 12.68 12.31 6 278466 105 110310722
Nodule 12.67 12.31 41 278431 32590 110278237
Paraneoplastic encephalomyelitis 12.65 12.31 7 278465 172 110310655
Myeloblast count increased 12.65 12.31 5 278467 55 110310772
Refractory anaemia with an excess of blasts 12.63 12.31 13 278459 834 110309993
Stasis dermatitis 12.59 12.31 19 278453 1803 110309024
Laryngeal leukoplakia 12.57 12.31 5 278467 56 110310771
Cystitis 12.56 12.31 106 278366 65930 110244897
Gastric neoplasm 12.54 12.31 9 278463 352 110310475
Lung consolidation 12.54 12.31 56 278416 10420 110300407
Vitamin D deficiency 12.53 12.31 17 278455 18535 110292292
Viral upper respiratory tract infection 12.52 12.31 5 278467 10203 110300624
Hyperlipasaemia 12.45 12.31 17 278455 1472 110309355
Metastatic choriocarcinoma 12.43 12.31 3 278469 4 110310823
Infected neoplasm 12.43 12.31 11 278461 584 110310243
Upper gastrointestinal perforation 12.41 12.31 5 278467 58 110310769
Retinal degeneration 12.41 12.31 18 278454 1648 110309179
Gastrointestinal wall thinning 12.38 12.31 6 278466 111 110310716
Cardiac arrest 12.37 12.31 389 278083 196364 110114463
CSF white blood cell count decreased 12.37 12.31 4 278468 23 110310804
Drug level below therapeutic 12.35 12.31 7 278465 11666 110299161
Acute coronary syndrome 12.33 12.31 100 278372 23012 110287815
Caesarean section 12.33 12.31 10 278462 13807 110297020

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01XA02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
OTHER ANTINEOPLASTIC AGENTS
Platinum compounds
FDA EXT N0000175073 Platinum-containing Compounds
FDA EPC N0000175413 Platinum-based Drug
MeSH PA D000970 Antineoplastic Agents
MeSH PA D003432 Cross-Linking Reagents
MeSH PA D007202 Indicators and Reagents
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:25435 mutagen
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:50249 anticoagulant
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:75835 anti-anaemic agent

Related Drugs by ATC class:

L01XA Platinum compounds 3 drugs
cisplatinoxaliplatinsatraplatin

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Breast cancer indication 254837009 DOID:1612
Malignant tumor of ovary indication 363443007 DOID:2394
Ewing's sarcoma off-label use 76909002 DOID:3369
Acute myeloid leukemia, disease off-label use 91861009
Small cell carcinoma of lung off-label use 254632001 DOID:5409
Non-small cell lung cancer off-label use 254637007 DOID:3908
Endometrial carcinoma off-label use 254878006 DOID:2871
Malignant tumor of head and/or neck off-label use 255056009
Seminoma of testis off-label use 255107005
Malignant tumor of cervix off-label use 363354003 DOID:4362
Malignant tumor of testis off-label use 363449006 DOID:2998
Malignant tumor of urinary bladder off-label use 399326009 DOID:11054
Metastatic Breast Carcinoma off-label use
Refractory Osteosarcoma off-label use
Neuroendocrine Prostate Carcinoma off-label use
Progressive Diffuse Large B-Cell Lymphoma off-label use
Acute vomiting contraindication 23971007
Acute infectious disease contraindication 63171007
Blood coagulation disorder contraindication 64779008 DOID:1247
Leukopenia contraindication 84828003 DOID:615
Kidney disease contraindication 90708001 DOID:557
Hearing disorder contraindication 128540005
Liver function tests abnormal contraindication 166603001
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Peripheral nerve disease contraindication 302226006
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Functional visual loss contraindication 313165001
Breastfeeding (mother) contraindication 413712001
Significant Bleeding contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019478 VUID
N0000147598 NUI
D01363 KEGG_DRUG
4019478 VANDF
C0079083 UMLSCUI
CHEBI:31355 CHEBI
QPT PDB_CHEM_ID
CHEMBL1351 ChEMBL_ID
D016190 MESH_DESCRIPTOR_UI
DB00958 DRUGBANK_ID
7624 IUPHAR_LIGAND_ID
5231 INN_ID
BG3F62OND5 UNII
426756 PUBCHEM_CID
152200 RXNORM
3186 MMSL
37674 MMSL
4357 MMSL
d00185 MMSL
002643 NDDF
108759002 SNOMEDCT_US
386905002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-4239 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 25 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-4239 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 25 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-4244 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 25 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-4244 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 25 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-4246 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 25 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-4246 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 25 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-4248 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 25 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-4248 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 25 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 16729-295 INJECTION 10 mg INTRAVENOUS ANDA 24 sections
carboplatin Human Prescription Drug Label 1 47335-150 INJECTION 10 mg INTRAVENOUS ANDA 22 sections
carboplatin Human Prescription Drug Label 1 47335-151 INJECTION 10 mg INTRAVENOUS ANDA 22 sections
carboplatin Human Prescription Drug Label 1 47335-284 INJECTION 10 mg INTRAVENOUS ANDA 22 sections
carboplatin Human Prescription Drug Label 1 47335-300 INJECTION 10 mg INTRAVENOUS ANDA 22 sections
CARBOPLATIN HUMAN PRESCRIPTION DRUG LABEL 1 54288-164 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 20 sections
CARBOPLATIN HUMAN PRESCRIPTION DRUG LABEL 1 54288-165 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 20 sections
CARBOPLATIN HUMAN PRESCRIPTION DRUG LABEL 1 54288-166 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 20 sections
CARBOPLATIN HUMAN PRESCRIPTION DRUG LABEL 1 54288-167 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 20 sections
CARBOPLATIN Human Prescription Drug Label 1 55150-333 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 23 sections
CARBOPLATIN Human Prescription Drug Label 1 55150-334 INJECTION, SOLUTION 150 mg INTRAVENOUS ANDA 23 sections
CARBOPLATIN Human Prescription Drug Label 1 55150-335 INJECTION, SOLUTION 450 mg INTRAVENOUS ANDA 23 sections
CARBOPLATIN Human Prescription Drug Label 1 55150-335 INJECTION, SOLUTION 450 mg INTRAVENOUS ANDA 23 sections
CARBOPLATIN Human Prescription Drug Label 1 55150-386 INJECTION, SOLUTION 600 mg INTRAVENOUS ANDA 23 sections
CARBOPLATIN Human Prescription Drug Label 1 55150-386 INJECTION, SOLUTION 600 mg INTRAVENOUS ANDA 23 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 57277-105 SOLUTION 50 mg INTRAVENOUS ANDA 22 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 57277-106 SOLUTION 150 mg INTRAVENOUS ANDA 22 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 57277-107 SOLUTION 450 mg INTRAVENOUS ANDA 22 sections
CARBOPLATIN HUMAN PRESCRIPTION DRUG LABEL 1 60505-6282 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 15 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 61703-150 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 23 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 61703-262 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 23 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 61703-339 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 24 sections