carboplatin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antineoplastic agents, platinum derivatives 4133 41575-94-4

Description:

MoleculeDescription

Synonyms:

  • paraplatin
  • carboplatin
An organoplatinum compound that possesses antineoplastic activity.
  • Molecular weight: 371.26
  • Formula: C6H12N2O4Pt
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 107.88
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 14 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 77 % Benet LZ, Broccatelli F, Oprea TI
Vd (Volume of distribution) 0.26 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 1 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
March 3, 1989 FDA
Aug. 25, 2021 PMDA MYLAN SEIYAKU Ltd

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neutropenia 1682.78 12.72 1844 110008 146121 50347151
Febrile neutropenia 1588.35 12.72 1478 110374 96189 50397083
Malignant neoplasm progression 1292.31 12.72 1125 110727 66999 50426273
Thrombocytopenia 1183.67 12.72 1433 110419 126240 50367032
Anaemia 1075.65 12.72 1965 109887 250491 50242781
Neutrophil count decreased 822.02 12.72 735 111117 45291 50447981
Disease progression 785.14 12.72 1012 110840 94854 50398418
Erythema 774.82 12.72 1256 110596 145158 50348114
Myelosuppression 678.66 12.72 404 111448 13113 50480159
Pancytopenia 672.16 12.72 877 110975 83153 50410119
Acute myeloid leukaemia 643.04 12.72 406 111446 14668 50478604
Drug ineffective 534.98 12.72 618 111234 818715 49674557
Haematotoxicity 422.60 12.72 246 111606 7649 50485623
Bone marrow failure 415.32 12.72 401 111451 27223 50466049
Flushing 412.46 12.72 617 111235 66398 50426874
Neutropenic sepsis 412.20 12.72 301 111551 13846 50479426
Neuropathy peripheral 407.47 12.72 751 111101 96006 50397266
Joint swelling 406.97 12.72 37 111815 245249 50248023
Vomiting 380.82 12.72 2012 109840 458746 50034526
Myelodysplastic syndrome 370.13 12.72 290 111562 14842 50478430
Rheumatoid arthritis 366.35 12.72 20 111832 202530 50290742
Platelet count decreased 341.78 12.72 714 111138 100012 50393260
Leukopenia 338.47 12.72 566 111286 66962 50426310
Pain 337.76 12.72 474 111378 578429 49914843
Neoplasm progression 331.05 12.72 364 111488 28793 50464479
Mucosal inflammation 330.01 12.72 425 111427 39717 50453555
Nausea 321.27 12.72 2652 109200 702746 49790526
Metastases to liver 302.46 12.72 292 111560 19812 50473460
Product dose omission issue 301.42 12.72 29 111823 183809 50309463
Anaphylactic shock 294.33 12.72 288 111564 19867 50473405
Contraindicated product administered 281.31 12.72 11 111841 148947 50344325
Dyspnoea 280.65 12.72 2117 109735 545491 49947781
Weight increased 274.69 12.72 56 111796 201835 50291437
Sinusitis 271.59 12.72 30 111822 170528 50322744
Hypokalaemia 271.16 12.72 600 111252 87392 50405880
Fall 270.79 12.72 207 111645 334725 50158547
Synovitis 257.57 12.72 3 111849 123862 50369410
Ovarian cancer recurrent 253.06 12.72 89 111763 793 50492479
Therapeutic product effect decreased 247.25 12.72 13 111839 136037 50357235
White blood cell count decreased 246.64 12.72 689 111163 116033 50377239
Dehydration 243.71 12.72 816 111036 151633 50341639
Systemic lupus erythematosus 236.33 12.72 20 111832 140602 50352670
Arthropathy 236.29 12.72 34 111818 157872 50335400
Peripheral swelling 228.16 12.72 85 111767 205851 50287421
Nasopharyngitis 219.90 12.72 76 111776 192851 50300421
Peripheral sensory neuropathy 219.10 12.72 152 111700 6439 50486833
Metastases to lung 218.63 12.72 187 111665 10833 50482439
Swelling 217.40 12.72 86 111766 200786 50292486
Metastases to central nervous system 214.82 12.72 187 111665 11095 50482177
Glossodynia 210.11 12.72 11 111841 115558 50377714
Headache 206.31 12.72 515 111337 506020 49987252
Arthralgia 204.70 12.72 414 111438 438288 50054984
Hypomagnesaemia 204.26 12.72 254 111598 22902 50470370
Abdominal discomfort 200.36 12.72 133 111719 231508 50261764
Second primary malignancy 198.87 12.72 146 111706 6768 50486504
Proteinuria 198.48 12.72 213 111639 16384 50476888
Abdominal pain 195.81 12.72 1034 110818 235194 50258078
Hand deformity 194.03 12.72 6 111846 100193 50393079
Metastases to bone 191.09 12.72 217 111635 17778 50475494
Maternal exposure during pregnancy 181.94 12.72 63 111789 159715 50333557
Injection site pain 180.60 12.72 18 111834 111006 50382266
Musculoskeletal stiffness 173.90 12.72 36 111816 128445 50364827
Palmar-plantar erythrodysaesthesia syndrome 171.75 12.72 217 111635 19881 50473391
Therapy partial responder 169.16 12.72 130 111722 6461 50486811
Product use in unapproved indication 165.88 12.72 598 111254 115221 50378051
Polyneuropathy 165.36 12.72 167 111685 11964 50481308
Drug intolerance 164.94 12.72 145 111707 218959 50274313
Gastrointestinal perforation 162.79 12.72 95 111757 2966 50490306
Overdose 162.65 12.72 16 111836 99711 50393561
Condition aggravated 160.19 12.72 256 111596 296802 50196470
Posterior reversible encephalopathy syndrome 160.18 12.72 181 111671 14747 50478525
Metastases to lymph nodes 157.61 12.72 128 111724 6896 50486376
Hepatic enzyme increased 156.68 12.72 54 111798 137326 50355946
Ascites 149.03 12.72 277 111575 35584 50457688
Wound 148.74 12.72 27 111825 105767 50387505
Metastases to peritoneum 142.99 12.72 85 111767 2748 50490524
Ileus 134.51 12.72 156 111696 13073 50480199
Feeling hot 131.73 12.72 277 111575 38925 50454347
Exposure during pregnancy 130.52 12.72 52 111800 120963 50372309
Pleural effusion 129.08 12.72 435 111417 81019 50412253
Product use issue 128.90 12.72 86 111766 149389 50343883
Neurotoxicity 127.29 12.72 160 111692 14580 50478692
Tumour lysis syndrome 125.41 12.72 115 111737 7306 50485966
Discomfort 124.60 12.72 42 111810 108338 50384934
General physical health deterioration 123.70 12.72 632 111220 141802 50351470
Diarrhoea 121.18 12.72 1897 109955 586579 49906693
Colitis 121.13 12.72 265 111587 38264 50455008
Large intestine perforation 120.58 12.72 113 111739 7381 50485891
Injection site erythema 117.14 12.72 14 111838 74922 50418350
Pyrexia 117.00 12.72 1319 110533 378884 50114388
Contusion 114.90 12.72 52 111800 112131 50381141
Drug abuse 114.36 12.72 4 111848 59842 50433430
Hospitalisation 113.16 12.72 10 111842 67927 50425345
Treatment failure 108.52 12.72 87 111765 137550 50355722
Influenza 107.72 12.72 32 111820 89506 50403766
Insomnia 107.69 12.72 137 111715 174728 50318544
Epistaxis 107.07 12.72 348 111504 63606 50429666
Sepsis 105.92 12.72 576 111276 132349 50360923
Psoriasis 105.16 12.72 14 111838 68986 50424286
Blood cholesterol increased 104.43 12.72 4 111848 55211 50438061
Arthritis 102.51 12.72 32 111820 86689 50406583
Tachycardia 101.97 12.72 464 111388 99299 50393973
Off label use 100.77 12.72 1538 110314 472888 50020384
Neutropenic colitis 100.29 12.72 64 111788 2353 50490919
Depression 96.36 12.72 135 111717 165288 50327984
Loss of personal independence in daily activities 96.05 12.72 19 111833 70031 50423241
Somnolence 94.82 12.72 122 111730 154863 50338409
Migraine 94.09 12.72 25 111827 75255 50418017
Suicide attempt 93.75 12.72 5 111847 51727 50441545
Irritable bowel syndrome 93.13 12.72 5 111847 51436 50441836
Pericarditis 93.07 12.72 29 111823 78660 50414612
Pneumonitis 92.79 12.72 203 111649 29307 50463965
Mobility decreased 91.85 12.72 31 111821 79917 50413355
Pulmonary embolism 91.57 12.72 456 111396 101248 50392024
Type I hypersensitivity 91.21 12.72 60 111792 2325 50490947
Pain in extremity 89.88 12.72 306 111546 272559 50220713
Oesophagitis 89.13 12.72 128 111724 13255 50480017
Hydronephrosis 88.98 12.72 102 111750 8439 50484833
Disease recurrence 88.33 12.72 159 111693 19922 50473350
Subileus 87.90 12.72 62 111790 2697 50490575
Small intestinal obstruction 87.60 12.72 140 111712 15928 50477344
Muscle spasms 87.46 12.72 89 111763 125464 50367808
Hypertension 87.16 12.72 779 111073 210424 50282848
Drug hypersensitivity 86.45 12.72 276 111576 250734 50242538
Palmar erythema 84.42 12.72 49 111803 1514 50491758
Embolism 84.31 12.72 90 111762 6878 50486394
Bronchitis 83.14 12.72 65 111787 104094 50389178
Decreased appetite 81.83 12.72 739 111113 200184 50293088
Hypersensitivity 80.92 12.72 778 111074 214383 50278889
Blister 80.81 12.72 44 111808 85374 50407898
Metastasis 80.24 12.72 71 111781 4304 50488968
Chest discomfort 79.44 12.72 410 111442 92312 50400960
Injection site swelling 79.09 12.72 3 111849 41770 50451502
Drug resistance 78.03 12.72 146 111706 18843 50474429
Fibromyalgia 76.61 12.72 6 111846 44972 50448300
Bronchospasm 76.33 12.72 126 111726 14728 50478544
Suicidal ideation 75.98 12.72 15 111837 55370 50437902
Peripheral motor neuropathy 75.01 12.72 44 111808 1387 50491885
Injection site reaction 74.24 12.72 11 111841 50021 50443251
EGFR gene mutation 74.19 12.72 26 111826 229 50493043
Memory impairment 73.45 12.72 42 111810 79318 50413954
Alveolar soft part sarcoma 73.45 12.72 21 111831 86 50493186
Hypertransaminasaemia 73.10 12.72 62 111790 3549 50489723
Acquired gene mutation 72.96 12.72 36 111816 795 50492477
Constipation 72.54 12.72 677 111175 185031 50308241
Asthma 72.25 12.72 55 111797 89282 50403990
Malignant pleural effusion 71.09 12.72 51 111801 2279 50490993
Recall phenomenon 70.30 12.72 31 111821 525 50492747
Secondary cerebellar degeneration 69.94 12.72 18 111834 44 50493228
Deep vein thrombosis 69.77 12.72 334 111518 72970 50420302
Asthenia 69.75 12.72 1040 110812 318002 50175270
Metastases to meninges 68.49 12.72 47 111805 1955 50491317
Hypocalcaemia 68.45 12.72 170 111682 26646 50466626
Injection site bruising 68.40 12.72 3 111849 36765 50456507
Drug interaction 68.34 12.72 220 111632 199401 50293871
Duodenal ulcer perforation 67.74 12.72 10 111842 45601 50447671
Radiation pneumonitis 67.23 12.72 40 111812 1295 50491977
Stress 66.96 12.72 18 111834 53775 50439497
Osteoarthritis 66.87 12.72 34 111818 68572 50424700
Gastrointestinal toxicity 66.71 12.72 66 111786 4611 50488661
Neutropenic infection 66.58 12.72 37 111815 1050 50492222
Blood pressure fluctuation 66.39 12.72 3 111849 35820 50457452
Enterocolitis infectious 65.99 12.72 41 111811 1437 50491835
Lower respiratory tract infection 65.70 12.72 68 111784 95133 50398139
Anaphylactic reaction 64.88 12.72 264 111588 53791 50439481
Skin toxicity 64.88 12.72 60 111792 3853 50489419
Gait disturbance 64.33 12.72 148 111704 149857 50343415
Inappropriate schedule of product administration 63.69 12.72 40 111812 71791 50421481
Lymphangiosis carcinomatosa 63.29 12.72 37 111815 1159 50492113
Metastatic neoplasm 63.09 12.72 58 111794 3696 50489576
Injury 61.60 12.72 16 111836 48909 50444363
Neoplasm recurrence 61.39 12.72 47 111805 2322 50490950
Haemolytic anaemia 60.60 12.72 88 111764 9204 50484068
Sense of oppression 60.17 12.72 33 111819 912 50492360
Ototoxicity 59.99 12.72 35 111817 1092 50492180
Choroidal infarction 59.78 12.72 17 111835 68 50493204
Hypotension 59.64 12.72 788 111064 234681 50258591
Thrombotic microangiopathy 58.42 12.72 84 111768 8707 50484565
Paraesthesia 57.74 12.72 459 111393 119784 50373488
Intentional product misuse 57.49 12.72 16 111836 46718 50446554
Cataract 56.70 12.72 17 111835 47283 50445989
Laryngospasm 56.16 12.72 47 111805 2641 50490631
Feeling abnormal 56.11 12.72 121 111731 125371 50367901
Recurrent cancer 54.86 12.72 39 111813 1718 50491554
Type 2 diabetes mellitus 54.77 12.72 6 111846 34369 50458903
Radiation oesophagitis 54.22 12.72 21 111831 251 50493021
Intestinal obstruction 53.91 12.72 154 111698 26229 50467043
Nephropathy toxic 53.77 12.72 77 111775 7952 50485320
Neutrophil count abnormal 53.46 12.72 44 111808 2415 50490857
Sleep disorder 53.46 12.72 30 111822 57253 50436019
Carbohydrate antigen 125 increased 53.33 12.72 44 111808 2423 50490849
Pregnancy 53.15 12.72 3 111849 29574 50463698
Anastomotic leak 51.97 12.72 23 111829 393 50492879
Urogenital fistula 51.78 12.72 17 111835 120 50493152
Cardiac failure congestive 50.98 12.72 67 111785 84315 50408957
Oxygen saturation decreased 50.80 12.72 306 111546 72942 50420330
Febrile bone marrow aplasia 50.54 12.72 66 111786 6245 50487027
Incorrect dose administered 50.24 12.72 22 111830 48392 50444880
Abortion spontaneous 50.10 12.72 15 111837 41757 50451515
Red blood cell sedimentation rate increased 49.88 12.72 4 111848 29412 50463860
Diabetes mellitus 49.76 12.72 23 111829 49010 50444262
Surgery 48.82 12.72 5 111847 30200 50463072
Enterocolitis 48.48 12.72 66 111786 6501 50486771
Device related thrombosis 47.85 12.72 32 111820 1275 50491997
Hyperhidrosis 47.75 12.72 350 111502 89076 50404196
Performance status decreased 47.27 12.72 46 111806 3149 50490123
Hallucination 47.17 12.72 22 111830 46635 50446637
Death 46.88 12.72 993 110859 324386 50168886
Hyponatraemia 46.70 12.72 368 111484 95771 50397501
Toxicity to various agents 46.58 12.72 277 111575 212222 50281050
C-reactive protein abnormal 46.55 12.72 4 111848 27805 50465467
Cardiotoxicity 46.49 12.72 67 111785 6960 50486312
Metastases to skin 46.21 12.72 32 111820 1351 50491921
Intestinal perforation 46.11 12.72 83 111769 10396 50482876
Lymphocele 45.91 12.72 26 111826 766 50492506
Anxiety 45.88 12.72 219 111633 177387 50315885
Unevaluable event 44.63 12.72 23 111829 46043 50447229
Hot flush 44.02 12.72 204 111648 43965 50449307
Aplasia 43.94 12.72 48 111804 3765 50489507
Urinary tract obstruction 43.81 12.72 34 111818 1714 50491558
Immune-mediated enterocolitis 43.81 12.72 28 111824 1032 50492240
Adverse event 43.68 12.72 21 111831 43742 50449530
Renal tubular disorder 43.60 12.72 39 111813 2398 50490874
Endocarditis noninfective 43.45 12.72 12 111840 42 50493230
Small intestinal perforation 43.29 12.72 30 111822 1268 50492004
Product quality issue 43.08 12.72 8 111844 30850 50462422
Disseminated intravascular coagulation 43.07 12.72 108 111744 17027 50476245
Anaphylactoid reaction 43.00 12.72 45 111807 3361 50489911
Gastric disorder 42.69 12.72 7 111845 29541 50463731
Pneumothorax 42.37 12.72 95 111757 13939 50479333
Throat tightness 41.92 12.72 121 111731 20726 50472546
Plasma cell myeloma 41.89 12.72 9 111843 31313 50461959
Sleep apnoea syndrome 41.17 12.72 3 111849 23865 50469407
Osteoporosis 41.16 12.72 24 111828 44855 50448417
Immune-mediated lung disease 40.77 12.72 19 111833 368 50492904
Acute promyelocytic leukaemia 40.68 12.72 25 111827 859 50492413
Impaired healing 40.55 12.72 57 111795 69729 50423543
Sedation 40.52 12.72 9 111843 30601 50462671
Drug reaction with eosinophilia and systemic symptoms 40.48 12.72 7 111845 28417 50464855
Metastases to spine 40.47 12.72 40 111812 2791 50490481
PIK3CA-activated mutation 40.09 12.72 24 111828 786 50492486
Hypophosphataemia 40.07 12.72 69 111783 8345 50484927
Joint stiffness 39.94 12.72 9 111843 30299 50462973
Septic shock 39.73 12.72 239 111613 56936 50436336
Tumour necrosis 39.61 12.72 23 111829 711 50492561
Ovarian epithelial cancer recurrent 38.89 12.72 9 111843 11 50493261
Heart rate decreased 38.80 12.72 16 111836 36481 50456791
Fluid retention 38.67 12.72 33 111819 50616 50442656
Ovarian disorder 38.48 12.72 22 111830 660 50492612
Aortitis 38.46 12.72 24 111828 848 50492424
Encephalopathy 38.36 12.72 162 111690 33549 50459723
Hypoalbuminaemia 38.27 12.72 74 111778 9786 50483486
Venous thrombosis 37.79 12.72 48 111804 4418 50488854
Hypertensive crisis 37.45 12.72 87 111765 13067 50480205
Femur fracture 37.36 12.72 18 111834 37446 50455826
Dizziness 37.31 12.72 540 111312 345829 50147443
Gastrooesophageal reflux disease 37.30 12.72 70 111782 76358 50416914
Hypoglycaemia 37.26 12.72 38 111814 53543 50439729
Joint injury 36.84 12.72 3 111849 21786 50471486
Metastases to abdominal wall 36.64 12.72 12 111840 84 50493188
Tumour embolism 36.46 12.72 13 111839 121 50493151
Irritability 36.35 12.72 9 111843 28417 50464855
BRCA2 gene mutation 36.22 12.72 11 111841 58 50493214
Skin candida 35.89 12.72 27 111825 1299 50491973
Nasal congestion 35.84 12.72 36 111816 51084 50442188
Terminal agitation 35.82 12.72 7 111845 0 50493272
Nephrolithiasis 35.63 12.72 16 111836 34677 50458595
Inflammation 35.60 12.72 44 111808 56868 50436404
Abdominal abscess 35.39 12.72 44 111808 3964 50489308
Papilloedema 35.37 12.72 41 111811 3432 50489840
Adverse drug reaction 35.28 12.72 42 111810 55180 50438092
Immune-mediated hepatitis 35.20 12.72 23 111829 881 50492391
Alopecia areata 35.14 12.72 27 111825 1341 50491931
Basal cell carcinoma 34.96 12.72 5 111847 23351 50469921
Immune-mediated hepatic disorder 34.86 12.72 13 111839 139 50493133
Pruritus 33.84 12.72 843 111009 282725 50210547
Bone pain 33.82 12.72 199 111653 47030 50446242
Wheezing 33.79 12.72 53 111799 61994 50431278
Pain in jaw 33.24 12.72 22 111830 38406 50454866
Folliculitis 33.20 12.72 23 111829 39202 50454070
Nervousness 33.03 12.72 10 111842 27641 50465631
Obstructive shock 32.92 12.72 9 111843 30 50493242
VIth nerve paralysis 32.90 12.72 21 111831 772 50492500
Herpes zoster 32.67 12.72 67 111785 70719 50422553
Cyanosis 32.36 12.72 90 111762 15094 50478178
Cerebral infarction 32.11 12.72 113 111739 21491 50471781
Pelvic abscess 31.83 12.72 26 111826 1412 50491860
Amnesia 31.69 12.72 28 111824 42232 50451040
Diffuse large B-cell lymphoma recurrent 31.50 12.72 27 111825 1568 50491704
Onycholysis 31.49 12.72 25 111827 1303 50491969
Device dislocation 31.36 12.72 5 111847 21541 50471731
Serotonin syndrome 31.27 12.72 8 111844 24705 50468567
Hypervolaemia 30.86 12.72 9 111843 25490 50467782
Madarosis 30.85 12.72 33 111819 2527 50490745
Colitis ischaemic 30.67 12.72 66 111786 9417 50483855
Rhabdomyolysis 30.32 12.72 25 111827 39002 50454270
Breast cancer 30.30 12.72 30 111822 42860 50450412
Hypoxia 30.14 12.72 205 111647 50918 50442354
Mental disorder 30.06 12.72 6 111846 21985 50471287
Breast cancer metastatic 30.00 12.72 69 111783 10295 50482977
Extravasation 29.95 12.72 29 111823 1973 50491299
Bronchial fistula 29.90 12.72 8 111844 24 50493248
Metastases to pleura 29.72 12.72 24 111828 1282 50491990
Psychotic disorder 29.72 12.72 6 111846 21806 50471466
Administration site extravasation 29.69 12.72 19 111833 702 50492570
Pseudocirrhosis 29.46 12.72 18 111834 612 50492660
Left ventricular dysfunction 29.37 12.72 69 111783 10437 50482835
Eastern Cooperative Oncology Group performance status worsened 29.25 12.72 18 111834 620 50492652
Liver function test abnormal 29.10 12.72 33 111819 44306 50448966
Blast cells present 28.93 12.72 15 111837 369 50492903
Bradycardia 28.88 12.72 62 111790 64364 50428908
Underdose 28.86 12.72 5 111847 20273 50472999
Therapy interrupted 28.61 12.72 5 111847 20147 50473125
Foot fracture 28.49 12.72 5 111847 20086 50473186
Dysphagia 28.42 12.72 279 111573 77239 50416033
Haemoptysis 28.41 12.72 122 111730 25451 50467821
Respiratory distress 28.33 12.72 138 111714 30351 50462921
Hip arthroplasty 28.29 12.72 16 111836 30413 50462859
Acute megakaryocytic leukaemia 28.28 12.72 6 111846 3 50493269
Dysaesthesia 28.28 12.72 38 111814 3697 50489575
Hypopituitarism 28.21 12.72 20 111832 877 50492395
Head injury 28.13 12.72 9 111843 24011 50469261
Renal salt-wasting syndrome 28.07 12.72 13 111839 248 50493024
Cold sweat 27.71 12.72 68 111784 10576 50482696
Tracheal fistula 27.56 12.72 8 111844 35 50493237
Haematuria 27.54 12.72 121 111731 25492 50467780
Muscle spasticity 27.37 12.72 3 111849 17181 50476091
Localised infection 27.37 12.72 11 111841 25474 50467798
Acute monocytic leukaemia 27.35 12.72 9 111843 64 50493208
Blood pressure systolic increased 27.18 12.72 23 111829 35426 50457846
Leukoencephalopathy 27.13 12.72 38 111814 3845 50489427
Paraneoplastic neurological syndrome 27.08 12.72 6 111846 5 50493267
Metastases to breast 27.07 12.72 13 111839 270 50493002
Tooth disorder 26.78 12.72 10 111842 24218 50469054
Double hit lymphoma 26.56 12.72 6 111846 6 50493266
Bursitis 26.45 12.72 8 111844 22127 50471145
Haemoglobin 26.33 12.72 11 111841 162 50493110
Skin laceration 26.05 12.72 5 111847 18837 50474435
Unmasking of previously unidentified disease 25.99 12.72 18 111834 760 50492512
Ejection fraction decreased 25.93 12.72 95 111757 18425 50474847
Metastases to chest wall 25.85 12.72 15 111837 463 50492809
Eye disorder 25.85 12.72 5 111847 18734 50474538
Medication error 25.80 12.72 25 111827 36079 50457193
Retinal pigment epitheliopathy 25.80 12.72 11 111841 171 50493101
Female genital tract fistula 25.79 12.72 36 111816 3630 50489642
Shock 25.68 12.72 102 111750 20548 50472724
Emphysematous cystitis 25.49 12.72 10 111842 124 50493148
Cancer pain 25.45 12.72 30 111822 2557 50490715
Metastases to adrenals 25.43 12.72 17 111835 677 50492595
Road traffic accident 25.37 12.72 11 111841 24341 50468931
Injection site rash 25.33 12.72 3 111849 16174 50477098
COVID-19 25.27 12.72 40 111812 46622 50446650
Nail disorder 25.25 12.72 62 111790 9646 50483626
Influenza like illness 25.17 12.72 56 111796 57403 50435869
Nightmare 25.14 12.72 3 111849 16083 50477189
Treatment noncompliance 25.09 12.72 18 111834 30132 50463140
Sciatica 25.06 12.72 8 111844 21374 50471898
Ill-defined disorder 24.99 12.72 52 111800 54602 50438670
Tumour hyperprogression 24.94 12.72 9 111843 87 50493185
Immune-mediated pancreatitis 24.80 12.72 8 111844 53 50493219
Haemoglobin decreased 24.77 12.72 407 111445 126809 50366463
Upper limb fracture 24.71 12.72 3 111849 15870 50477402
Myocardial infarction 24.62 12.72 107 111745 88920 50404352
Tremor 24.51 12.72 151 111701 114752 50378520
Malignant ascites 24.50 12.72 18 111834 835 50492437
Coronary artery disease 24.41 12.72 18 111834 29708 50463564
Ankle fracture 24.41 12.72 3 111849 15719 50477553
Infected lymphocele 24.34 12.72 11 111841 198 50493074
Obesity 24.18 12.72 4 111848 16771 50476501
Chills 24.18 12.72 323 111529 96364 50396908
Weight decreased 24.11 12.72 344 111508 220901 50272371
Sopor 24.09 12.72 7 111845 19872 50473400
Dysstasia 24.07 12.72 5 111847 17814 50475458
Confusional state 23.98 12.72 279 111573 185649 50307623
Pneumonia 23.95 12.72 645 111207 377756 50115516
Metastases to pelvis 23.94 12.72 13 111839 352 50492920
Ovarian cancer metastatic 23.91 12.72 17 111835 749 50492523
Thrombophlebitis migrans 23.75 12.72 9 111843 101 50493171
Immune-mediated hypothyroidism 23.72 12.72 8 111844 62 50493210
Eye pain 23.65 12.72 17 111835 28432 50464840
Live birth 23.45 12.72 4 111848 16404 50476868
Gastric perforation 23.33 12.72 22 111830 1448 50491824
Rectal perforation 23.29 12.72 13 111839 372 50492900
Crying 23.29 12.72 8 111844 20408 50472864
Panic attack 23.09 12.72 7 111845 19335 50473937
Hyperpyrexia 23.05 12.72 31 111821 3018 50490254
Venoocclusive liver disease 23.05 12.72 37 111815 4224 50489048
Hormone receptor positive breast cancer 23.02 12.72 14 111838 472 50492800
Upper respiratory tract infection 22.95 12.72 72 111780 65826 50427446
Rash maculo-papular 22.92 12.72 118 111734 26523 50466749
Haemoglobinaemia 22.88 12.72 7 111845 38 50493234
Lymphadenopathy mediastinal 22.87 12.72 28 111824 2483 50490789
Cytopenia 22.78 12.72 56 111796 8719 50484553
Acute myelomonocytic leukaemia 22.75 12.72 10 111842 168 50493104
Embolism venous 22.74 12.72 28 111824 2497 50490775
Blood glucose increased 22.74 12.72 81 111771 71243 50422029
Dyskinesia 22.71 12.72 17 111835 27844 50465428
Metastases to bladder 22.69 12.72 10 111842 169 50493103
Vaginal fistula 22.68 12.72 13 111839 392 50492880
Hair colour changes 22.61 12.72 29 111823 2695 50490577
Product prescribing error 22.59 12.72 9 111843 20952 50472320
Vena cava thrombosis 22.52 12.72 25 111827 1996 50491276
Faecaloma 22.45 12.72 49 111803 7059 50486213
Autoimmune myocarditis 22.43 12.72 7 111845 41 50493231
Bacterial tracheitis 22.42 12.72 6 111846 18 50493254
Non-small cell lung cancer 22.42 12.72 30 111822 2907 50490365
Myeloid leukaemia 22.40 12.72 12 111840 316 50492956
Oesophagobronchial fistula 22.15 12.72 7 111845 43 50493229
Radiation skin injury 22.10 12.72 17 111835 846 50492426
Acute lymphocytic leukaemia 22.07 12.72 26 111826 2215 50491057
Tendonitis 21.93 12.72 5 111847 16700 50476572
Metastases to kidney 21.92 12.72 10 111842 184 50493088
Gait inability 21.75 12.72 30 111822 36997 50456275
Heavy menstrual bleeding 21.75 12.72 4 111848 15533 50477739
Accidental overdose 21.69 12.72 8 111844 19525 50473747
Bicytopenia 21.66 12.72 24 111828 1912 50491360
Dermatitis acneiform 21.63 12.72 35 111817 4022 50489250
Gastropleural fistula 21.62 12.72 7 111845 47 50493225
Joint range of motion decreased 21.56 12.72 7 111845 18505 50474767
Bladder perforation 21.52 12.72 9 111843 133 50493139
Cervix carcinoma recurrent 21.51 12.72 6 111846 22 50493250
Failure to thrive 21.43 12.72 45 111807 6313 50486959
Urosepsis 21.37 12.72 79 111773 15386 50477886
Haemolytic uraemic syndrome 21.35 12.72 26 111826 2293 50490979
Hypersomnia 21.31 12.72 4 111848 15310 50477962
Acoustic stimulation tests abnormal 21.25 12.72 8 111844 88 50493184
Splenic artery thrombosis 21.25 12.72 7 111845 50 50493222
Rib fracture 21.13 12.72 8 111844 19213 50474059
Product substitution issue 21.06 12.72 3 111849 14054 50479218
Scintillating scotoma 20.99 12.72 9 111843 142 50493130
Tumour haemorrhage 20.97 12.72 20 111832 1335 50491937
Respiratory failure 20.92 12.72 300 111552 90881 50402391
Device issue 20.84 12.72 9 111843 19963 50473309
Pelvic infection 20.73 12.72 11 111841 284 50492988
Balance disorder 20.66 12.72 83 111769 70507 50422765
Procedural pain 20.61 12.72 3 111849 13829 50479443
Tachypnoea 20.60 12.72 75 111777 14502 50478770
Breast cancer recurrent 20.51 12.72 33 111819 3775 50489497
Face oedema 20.51 12.72 86 111766 17753 50475519
Heat cramps 20.47 12.72 4 111848 0 50493272
Pericardial effusion 20.41 12.72 111 111741 25478 50467794
Tumour marker increased 20.30 12.72 33 111819 3807 50489465
Kidney infection 20.28 12.72 8 111844 18738 50474534
Laryngeal cancer stage III 20.11 12.72 5 111847 10 50493262
Endometrial cancer recurrent 20.11 12.72 5 111847 10 50493262
Superior vena cava syndrome 20.11 12.72 14 111838 596 50492676
Viral infection 20.03 12.72 22 111830 29964 50463308
BRAF V600E mutation positive 20.02 12.72 6 111846 30 50493242
Gastrointestinal fistula 20.02 12.72 12 111840 394 50492878
Wound dehiscence 19.96 12.72 35 111817 4295 50488977
Spinal cord paralysis 19.86 12.72 6 111846 31 50493241
Rash pruritic 19.85 12.72 48 111804 47798 50445474
Pulse absent 19.80 12.72 37 111815 4769 50488503
BRCA1 gene mutation 19.79 12.72 5 111847 11 50493261
Limb injury 19.78 12.72 10 111842 20240 50473032
Sinus disorder 19.77 12.72 8 111844 18450 50474822
Hyperlipidaemia 19.70 12.72 7 111845 17483 50475789
Radiation mucositis 19.70 12.72 6 111846 32 50493240
Respiratory fatigue 19.65 12.72 8 111844 110 50493162
Intestinal metastasis 19.58 12.72 8 111844 111 50493161
Spinal cord infarction 19.55 12.72 10 111842 239 50493033
Skin reaction 19.39 12.72 63 111789 11505 50481767
Sinus tachycardia 19.37 12.72 96 111756 21258 50472014
Ovarian cancer 19.20 12.72 38 111814 5111 50488161
Gastrointestinal disorder 19.18 12.72 126 111726 94330 50398942
Jaw operation 19.18 12.72 15 111837 765 50492507
Emotional distress 19.17 12.72 21 111831 28642 50464630
Small cell lung cancer 19.05 12.72 20 111832 1499 50491773
Ureteric fistula 18.94 12.72 5 111847 14 50493258
Aorto-oesophageal fistula 18.94 12.72 5 111847 14 50493258
Onychalgia 18.92 12.72 15 111837 780 50492492
Oropharyngeal pain 18.88 12.72 98 111754 77703 50415569
Angiodermatitis 18.84 12.72 7 111845 74 50493198
Myocarditis 18.84 12.72 49 111803 7898 50485374
Product administration error 18.83 12.72 10 111842 19689 50473583
Pulmonary vascular disorder 18.83 12.72 11 111841 344 50492928
Capillary leak syndrome 18.73 12.72 22 111830 1868 50491404
Retroperitoneal abscess 18.61 12.72 8 111844 127 50493145
Cholangitis 18.55 12.72 35 111817 4544 50488728
Pulmonary haemorrhage 18.55 12.72 43 111809 6449 50486823
Agranulocytosis 18.51 12.72 95 111757 21326 50471946
Laryngeal oedema 18.49 12.72 37 111815 5016 50488256
Bone marrow infiltration 18.45 12.72 12 111840 456 50492816
Vaginal perforation 18.44 12.72 5 111847 16 50493256
Retinoblastoma 18.43 12.72 7 111845 79 50493193
Metastases to the mediastinum 18.40 12.72 12 111840 458 50492814
Wrong technique in product usage process 18.39 12.72 62 111790 55448 50437824
Foetal exposure during pregnancy 18.35 12.72 20 111832 27339 50465933
Jugular vein thrombosis 18.26 12.72 26 111826 2670 50490602
Optic glioma 18.24 12.72 4 111848 3 50493269
Meningitis herpes 18.23 12.72 9 111843 199 50493073
Tumour fistulisation 18.21 12.72 5 111847 17 50493255
Full blood count abnormal 18.14 12.72 15 111837 23373 50469899
Neck pain 18.06 12.72 65 111787 57002 50436270
Swollen tongue 18.04 12.72 22 111830 28608 50464664
Duodenal perforation 18.02 12.72 14 111838 707 50492565
Myositis 17.93 12.72 48 111804 7872 50485400
Spinal stenosis 17.90 12.72 4 111848 13546 50479726
Bacterial diarrhoea 17.85 12.72 6 111846 46 50493226
Acute erythroid leukaemia 17.85 12.72 6 111846 46 50493226
Intestinal strangulation 17.76 12.72 7 111845 88 50493184
Neoplasm 17.75 12.72 40 111812 5888 50487384
Oral herpes 17.74 12.72 12 111840 20713 50472559
Blood potassium increased 17.74 12.72 7 111845 16391 50476881
Aortic dissection rupture 17.70 12.72 4 111848 4 50493268
Plantar erythema 17.64 12.72 9 111843 214 50493058
Electrolyte imbalance 17.62 12.72 80 111772 17089 50476183
Pseudomembranous colitis 17.62 12.72 26 111826 2759 50490513
Infusion site thrombosis 17.62 12.72 7 111845 90 50493182
Mechanical ileus 17.61 12.72 10 111842 296 50492976
Gastrointestinal necrosis 17.52 12.72 25 111827 2573 50490699
Hepatic function abnormal 17.48 12.72 128 111724 32553 50460719
Agitation 17.43 12.72 60 111792 53324 50439948
Fatigue 17.41 12.72 1338 110514 706263 49787009
Abnormal behaviour 17.34 12.72 11 111841 19647 50473625
Peritonitis 17.29 12.72 74 111778 15412 50477860
Lymphadenopathy 17.23 12.72 130 111722 33369 50459903
Bronchostenosis 17.22 12.72 11 111841 405 50492867
Nephritis 17.19 12.72 22 111830 2040 50491232
Platelet count abnormal 17.17 12.72 26 111826 2823 50490449
Clostridium test positive 17.11 12.72 22 111830 2050 50491222
No adverse event 17.05 12.72 30 111822 33548 50459724
Paraneoplastic syndrome 17.03 12.72 12 111840 521 50492751
Iris atrophy 17.01 12.72 6 111846 54 50493218
Interstitial lung disease 16.93 12.72 186 111666 52990 50440282
Iron deficiency anaemia 16.92 12.72 8 111844 16826 50476446
Joint effusion 16.89 12.72 4 111848 13017 50480255
Right ventricular failure 16.84 12.72 7 111845 15886 50477386
Acute leukaemia 16.83 12.72 16 111836 1064 50492208
Coating in mouth 16.75 12.72 8 111844 164 50493108
Ocular vascular disorder 16.74 12.72 10 111842 326 50492946
Cerebral ischaemia 16.73 12.72 39 111813 5869 50487403
Pancreatitis 16.71 12.72 44 111808 42570 50450702
Drug level increased 16.70 12.72 11 111841 19257 50474015
Therapeutic product effect incomplete 16.66 12.72 126 111726 91389 50401883
Tumour associated fever 16.62 12.72 8 111844 167 50493105
Extrapyramidal disorder 16.54 12.72 3 111849 11767 50481505
Ear pain 16.52 12.72 23 111829 28260 50465012
Lymphoedema 16.50 12.72 51 111801 9071 50484201
Hallucination, visual 16.48 12.72 8 111844 16574 50476698
Peritoneal disorder 16.48 12.72 11 111841 437 50492835
Glaucoma 16.47 12.72 7 111845 15679 50477593
Cerebrovascular accident 16.47 12.72 132 111720 94548 50398724
Sideroblastic anaemia 16.44 12.72 4 111848 7 50493265
Vaginal cuff dehiscence 16.44 12.72 4 111848 7 50493265
Therapy cessation 16.38 12.72 20 111832 25991 50467281
Bone erosion 16.38 12.72 3 111849 11684 50481588
Intestinal ischaemia 16.37 12.72 42 111810 6715 50486557
Neonatal respiratory depression 16.36 12.72 6 111846 61 50493211
Seasonal allergy 16.32 12.72 6 111846 14670 50478602
Blood culture positive 16.31 12.72 32 111820 4276 50488996
Vesical fistula 16.27 12.72 6 111846 62 50493210
Hypothyroidism 16.21 12.72 130 111722 33995 50459277
Alopecia 16.18 12.72 415 111437 244632 50248640
Chronic obstructive pulmonary disease 16.17 12.72 62 111790 53373 50439899
Hair texture abnormal 16.14 12.72 29 111823 3627 50489645
Ischaemic stroke 16.14 12.72 74 111778 15874 50477398
Barotrauma 16.12 12.72 8 111844 179 50493093
Retinal infarction 16.10 12.72 6 111846 64 50493208
Application site recall reaction 16.09 12.72 4 111848 8 50493264
Arterioenteric fistula 16.09 12.72 4 111848 8 50493264
Thyroiditis 16.08 12.72 20 111832 1802 50491470
Wrist fracture 15.99 12.72 3 111849 11484 50481788
Embolism arterial 15.96 12.72 14 111838 839 50492433
Fungal infection 15.93 12.72 26 111826 29939 50463333
Neutrophil count 15.93 12.72 9 111843 264 50493008
Gastroenteritis viral 15.92 12.72 11 111841 18775 50474497
Pyomyositis 15.83 12.72 10 111842 361 50492911
Poisoning 15.77 12.72 4 111848 12425 50480847
Ocular hyperaemia 15.76 12.72 13 111839 20279 50472993
Osteosarcoma 15.69 12.72 7 111845 122 50493150
Intestinal prolapse 15.69 12.72 7 111845 122 50493150
Blood triglycerides increased 15.64 12.72 3 111849 11309 50481963
Glioblastoma multiforme 15.62 12.72 13 111839 725 50492547
Inappropriate antidiuretic hormone secretion 15.61 12.72 64 111788 13079 50480193
Laryngeal discomfort 15.59 12.72 9 111843 275 50492997
Joint dislocation 15.59 12.72 4 111848 12329 50480943
Colitis ulcerative 15.47 12.72 9 111843 16845 50476427
Systemic infection 15.44 12.72 22 111830 2261 50491011
Fracture 15.44 12.72 9 111843 16824 50476448
Ileal perforation 15.40 12.72 10 111842 379 50492893
Diffuse large B-cell lymphoma refractory 15.36 12.72 15 111837 1031 50492241
Therapeutic response unexpected 15.33 12.72 8 111844 15907 50477365
Polymicrogyria 15.25 12.72 6 111846 75 50493197
Device related infection 15.25 12.72 88 111764 20647 50472625
Glioma 15.19 12.72 9 111843 289 50492983
Cachexia 15.18 12.72 32 111820 4501 50488771
Peripheral paralysis 15.11 12.72 6 111846 77 50493195
Ovarian epithelial cancer 15.11 12.72 9 111843 292 50492980
Ovarian cyst 15.10 12.72 6 111846 13990 50479282
Cholangitis sclerosing 15.09 12.72 16 111836 1213 50492059
Head discomfort 15.08 12.72 3 111849 11016 50482256
Soft tissue necrosis 15.07 12.72 10 111842 393 50492879
Skin oedema 14.97 12.72 13 111839 768 50492504
Nail discolouration 14.92 12.72 22 111830 2332 50490940
Areflexia 14.85 12.72 24 111828 2756 50490516
Eye excision 14.80 12.72 5 111847 39 50493233
Hepatotoxicity 14.77 12.72 107 111745 27119 50466153
Acne 14.67 12.72 13 111839 19582 50473690
Gene mutation 14.65 12.72 16 111836 1255 50492017
Immune-mediated myocarditis 14.64 12.72 6 111846 84 50493188
Electrocardiogram QT prolonged 14.56 12.72 62 111790 51824 50441448
Abdominal compartment syndrome 14.52 12.72 11 111841 535 50492737
Hallucination, auditory 14.51 12.72 3 111849 10725 50482547
Post procedural fistula 14.49 12.72 8 111844 224 50493048
Optic atrophy 14.48 12.72 15 111837 1107 50492165
Subacute cutaneous lupus erythematosus 14.48 12.72 21 111831 2194 50491078
Epiphyses premature fusion 14.47 12.72 5 111847 42 50493230
Impaired work ability 14.47 12.72 6 111846 13634 50479638
Laboratory test abnormal 14.45 12.72 18 111834 23190 50470082
Incorrect route of product administration 14.44 12.72 12 111840 18654 50474618
International normalised ratio increased 14.43 12.72 48 111804 43104 50450168
Ulcer 14.42 12.72 14 111838 20186 50473086
Anal sphincter atony 14.40 12.72 8 111844 227 50493045
Dermatitis 14.33 12.72 66 111786 14185 50479087
Cholelithiasis 14.30 12.72 40 111812 37933 50455339
Metastases to pancreas 14.27 12.72 8 111844 231 50493041
Macular degeneration 14.21 12.72 7 111845 14381 50478891
Immune-mediated encephalitis 14.21 12.72 6 111846 91 50493181
Lactic acidosis 14.21 12.72 33 111819 33322 50459950
Uterine adhesions 14.17 12.72 5 111847 45 50493227
Streptococcus test positive 14.09 12.72 15 111837 1142 50492130
Dementia 14.05 12.72 9 111843 15988 50477284
Thymus enlargement 14.03 12.72 6 111846 94 50493178
Thrombotic thrombocytopenic purpura 14.03 12.72 27 111825 3558 50489714
Anal haemorrhage 14.03 12.72 18 111834 1674 50491598
Hydrocephalus 13.99 12.72 32 111820 4756 50488516
Peritoneal neoplasm 13.98 12.72 5 111847 47 50493225
Gout 13.97 12.72 4 111848 11466 50481806
Melanoderma 13.97 12.72 7 111845 160 50493112
Rectal tenesmus 13.96 12.72 10 111842 446 50492826
Hepatitis B reactivation 13.95 12.72 20 111832 2067 50491205
Urge incontinence 13.94 12.72 12 111840 701 50492571
Hepatic cancer metastatic 13.93 12.72 9 111843 338 50492934
Systemic scleroderma 13.91 12.72 13 111839 846 50492426
Lung cancer metastatic 13.91 12.72 21 111831 2274 50490998
Hydroureter 13.88 12.72 9 111843 340 50492932
Metastases to vagina 13.87 12.72 4 111848 17 50493255
Chromosomal mutation 13.87 12.72 4 111848 17 50493255
Pharyngitis 13.86 12.72 11 111841 17492 50475780
Enterocutaneous fistula 13.81 12.72 15 111837 1169 50492103
Blood pressure increased 13.79 12.72 209 111643 132923 50360349
Malignant transformation 13.72 12.72 9 111843 347 50492925
Calcium ionised increased 13.69 12.72 6 111846 100 50493172
Pneumoretroperitoneum 13.69 12.72 4 111848 18 50493254
Epiglottitis 13.65 12.72 9 111843 350 50492922
Lymphorrhoea 13.62 12.72 5 111847 51 50493221
Musculoskeletal disorder 13.61 12.72 11 111841 17338 50475934
Emphysematous pyelonephritis 13.55 12.72 7 111845 171 50493101
Immune-mediated cholangitis 13.51 12.72 4 111848 19 50493253
Eczema asteatotic 13.50 12.72 8 111844 257 50493015
Dry eye 13.47 12.72 32 111820 32063 50461209
Hypermagnesaemia 13.47 12.72 13 111839 881 50492391
Hepatitis 13.44 12.72 117 111735 31336 50461936
Syncope 13.39 12.72 310 111542 102692 50390580
Spinal fracture 13.35 12.72 9 111843 15564 50477708
Hip fracture 13.32 12.72 23 111829 25908 50467364
Postoperative adhesion 13.28 12.72 8 111844 265 50493007
Acquired tracheo-oesophageal fistula 13.28 12.72 3 111849 3 50493269
Ventriculo-peritoneal shunt 13.28 12.72 3 111849 3 50493269
Kernicterus 13.28 12.72 3 111849 3 50493269
Stress cardiomyopathy 13.26 12.72 43 111809 7844 50485428
Gastric neoplasm 13.25 12.72 8 111844 266 50493006
Subdural haematoma 13.25 12.72 6 111846 12941 50480331
Bone density decreased 13.24 12.72 4 111848 11071 50482201
Full blood count decreased 13.23 12.72 18 111834 22328 50470944
Anhidrosis 13.22 12.72 6 111846 109 50493163
Respiratory depression 13.20 12.72 5 111847 12005 50481267
Subclavian vein thrombosis 13.16 12.72 18 111834 1781 50491491
Fistula 13.10 12.72 44 111808 8174 50485098
Clostridium bacteraemia 13.08 12.72 7 111845 184 50493088
Oesophageal stenosis 13.04 12.72 23 111829 2835 50490437
Fear 13.03 12.72 8 111844 14541 50478731
Metastases to stomach 13.01 12.72 7 111845 186 50493086
Peripheral ischaemia 12.97 12.72 29 111823 4247 50489025
Cardiac disorder 12.91 12.72 50 111802 42929 50450343
Night sweats 12.91 12.72 35 111817 33539 50459733
Visual impairment 12.90 12.72 93 111759 68182 50425090
Liver sarcoidosis 12.88 12.72 4 111848 23 50493249
Paronychia 12.79 12.72 30 111822 4534 50488738
Large intestinal obstruction 12.78 12.72 18 111834 1831 50491441
Immune-mediated hyperthyroidism 12.74 12.72 4 111848 24 50493248
Abdominal infection 12.72 12.72 17 111835 1645 50491627

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Malignant neoplasm progression 1077.08 13.21 1113 72807 72746 29427861
Febrile neutropenia 991.91 13.21 1307 72613 110933 29389674
Neutropenia 762.21 13.21 1257 72663 130454 29370153
Thrombocytopenia 594.45 13.21 1143 72777 133680 29366927
Pancytopenia 546.44 13.21 842 73078 82326 29418281
Disease progression 451.56 13.21 766 73154 81150 29419457
Mucosal inflammation 444.76 13.21 468 73452 31127 29469480
Leukopenia 373.55 13.21 567 73353 54636 29445971
Anaemia 372.10 13.21 1224 72696 199727 29300880
Neutrophil count decreased 350.84 13.21 486 73434 43081 29457526
Bone marrow failure 339.74 13.21 380 73540 27069 29473538
Interstitial lung disease 339.53 13.21 556 73364 57162 29443445
Myelosuppression 314.77 13.21 254 73666 11973 29488634
Haematotoxicity 273.96 13.21 184 73736 6515 29494092
Radiation pneumonitis 260.20 13.21 122 73798 2107 29498500
Off label use 209.57 13.21 1375 72545 299425 29201182
Completed suicide 205.77 13.21 4 73916 90242 29410365
Neutropenic sepsis 194.61 13.21 190 73730 11537 29489070
Pneumonitis 193.66 13.21 291 73629 27753 29472854
Product use in unapproved indication 190.39 13.21 562 73358 86313 29414294
Neoplasm progression 187.54 13.21 232 73688 18380 29482227
Drug abuse 184.33 13.21 3 73917 79880 29420727
Product dose omission issue 179.17 13.21 17 73903 96366 29404241
Febrile bone marrow aplasia 173.03 13.21 145 73775 7206 29493401
Metastases to central nervous system 168.55 13.21 141 73779 6990 29493617
Haemoptysis 163.07 13.21 282 73638 30268 29470339
Fall 156.65 13.21 128 73792 177050 29323557
Therapy partial responder 142.31 13.21 112 73808 5087 29495520
Dehydration 133.33 13.21 604 73316 114144 29386463
Overdose 127.03 13.21 23 73897 79796 29420811
Sepsis 123.45 13.21 691 73229 141991 29358616
Radiation oesophagitis 122.89 13.21 44 73876 362 29500245
Immune-mediated lung disease 114.93 13.21 50 73870 718 29499889
Nasopharyngitis 107.02 13.21 12 73908 59653 29440954
Platelet count decreased 106.28 13.21 530 73390 104142 29396465
Headache 104.77 13.21 171 73749 173836 29326771
White blood cell count decreased 99.14 13.21 442 73478 82920 29417687
Depression 96.55 13.21 46 73874 85101 29415506
Cytopenia 96.26 13.21 121 73799 9738 29490869
Metastases to bone 95.88 13.21 121 73799 9777 29490830
General physical health deterioration 93.45 13.21 505 73415 102352 29398255
Drug interaction 92.98 13.21 224 73696 197161 29303446
Septic shock 92.71 13.21 355 73565 62205 29438402
Weight increased 90.70 13.21 39 73881 76628 29423979
Skin toxicity 90.01 13.21 75 73845 3696 29496911
Metastases to meninges 82.43 13.21 46 73874 1159 29499448
Pyrexia 81.84 13.21 1086 72834 286536 29214071
Oesophagitis 81.23 13.21 123 73797 11800 29488807
Anxiety 79.98 13.21 58 73862 85307 29415300
Tremor 79.94 13.21 42 73878 73496 29427111
Bradycardia 79.86 13.21 32 73888 65597 29435010
Joint swelling 79.59 13.21 14 73906 49616 29450991
Hospitalisation 78.21 13.21 11 73909 45977 29454630
Toxicity to various agents 77.15 13.21 203 73717 173458 29327149
Decreased appetite 76.77 13.21 623 73297 144719 29355888
Immune-mediated enterocolitis 76.33 13.21 49 73871 1604 29499003
Peripheral swelling 76.06 13.21 32 73888 63707 29436900
Aplasia 75.32 13.21 70 73850 3993 29496614
Pneumothorax 71.47 13.21 136 73784 15706 29484901
Feeling abnormal 70.52 13.21 24 73896 54421 29446186
Intentional product misuse 70.38 13.21 4 73916 34657 29465950
Insomnia 70.12 13.21 71 73849 88690 29411917
Suicide attempt 69.06 13.21 4 73916 34106 29466501
Colitis 68.16 13.21 202 73718 31046 29469561
Plasma cell myeloma 67.73 13.21 7 73913 37108 29463499
Blood pressure increased 66.74 13.21 52 73868 73751 29426856
Drug ineffective 65.11 13.21 588 73332 362582 29138025
Acute myeloid leukaemia 63.96 13.21 133 73787 16380 29484227
Cardiac failure congestive 63.09 13.21 59 73861 76522 29424085
Injection site pain 62.21 13.21 5 73915 32441 29468166
Suicidal ideation 62.19 13.21 7 73913 34709 29465898
Dysphagia 62.08 13.21 287 73633 54639 29445968
Bronchial fistula 61.34 13.21 21 73899 149 29500458
Tracheo-oesophageal fistula 61.12 13.21 27 73893 403 29500204
Hallucination 60.95 13.21 18 73902 44694 29455913
Choroidal infarction 60.34 13.21 18 73902 76 29500531
Retinal pigment epitheliopathy 60.31 13.21 22 73898 192 29500415
Second primary malignancy 60.28 13.21 79 73841 6626 29493981
Arthralgia 59.12 13.21 167 73753 139450 29361157
Metastases to liver 58.77 13.21 106 73814 11750 29488857
Diffuse large B-cell lymphoma recurrent 58.58 13.21 50 73870 2547 29498060
Electrocardiogram QT prolonged 58.36 13.21 10 73910 36127 29464480
Small intestinal perforation 57.70 13.21 41 73879 1591 29499016
Dizziness 57.62 13.21 261 73659 189423 29311184
Muscle spasms 56.17 13.21 48 73872 65034 29435573
Myelodysplastic syndrome 56.13 13.21 132 73788 17662 29482945
Myocardial infarction 56.03 13.21 120 73800 110176 29390431
Hypomagnesaemia 55.55 13.21 130 73790 17338 29483269
Pain in extremity 55.40 13.21 121 73799 110312 29390295
Non-small cell lung cancer 54.56 13.21 51 73869 2930 29497677
Cardiac disorder 52.65 13.21 14 73906 37249 29463358
Vomiting 51.19 13.21 779 73141 211481 29289126
Pleural effusion 51.01 13.21 331 73589 71577 29429030
Immune-mediated hepatic disorder 49.76 13.21 22 73898 329 29500278
Neutropenic colitis 49.51 13.21 44 73876 2367 29498240
Anaplastic lymphoma kinase gene mutation 48.19 13.21 16 73904 102 29500505
Blood glucose increased 47.92 13.21 46 73874 58938 29441669
Therapeutic product effect decreased 47.89 13.21 8 73912 29443 29471164
Hypoglycaemia 47.72 13.21 31 73889 48315 29452292
Intestinal perforation 47.57 13.21 78 73842 8008 29492599
Influenza 46.87 13.21 23 73897 41858 29458749
Metastases to lung 46.52 13.21 76 73844 7779 29492828
Superior vena cava syndrome 46.39 13.21 24 73896 517 29500090
Tumour lysis syndrome 45.99 13.21 105 73815 13779 29486828
Musculoskeletal stiffness 45.98 13.21 18 73902 37440 29463167
Alopecia 45.11 13.21 127 73793 18957 29481650
Enteritis 44.76 13.21 69 73851 6722 29493885
Rhabdomyolysis 44.28 13.21 52 73868 60756 29439851
Abdominal discomfort 44.25 13.21 33 73887 47870 29452737
Pulmonary radiation injury 43.94 13.21 13 73907 53 29500554
Portal venous gas 43.80 13.21 20 73900 324 29500283
Gait disturbance 43.19 13.21 73 73847 73276 29427331
Kounis syndrome 42.87 13.21 36 73884 1793 29498814
Cardiotoxicity 42.81 13.21 56 73864 4688 29495919
Adrenal insufficiency 42.43 13.21 89 73831 11025 29489582
Pulmonary vascular disorder 42.14 13.21 23 73897 554 29500053
Vision blurred 42.11 13.21 24 73896 40152 29460455
Asthma 41.99 13.21 16 73904 33833 29466774
Agitation 41.69 13.21 40 73880 51264 29449343
Condition aggravated 41.62 13.21 206 73714 146089 29354518
Loss of personal independence in daily activities 41.16 13.21 7 73913 25433 29475174
Neuropathy peripheral 41.02 13.21 311 73609 70716 29429891
Recall phenomenon 40.95 13.21 22 73898 513 29500094
Nephrolithiasis 40.93 13.21 7 73913 25327 29475280
Memory impairment 40.85 13.21 20 73900 36450 29464157
Aggression 40.56 13.21 19 73901 35522 29465085
Hypokalaemia 40.56 13.21 239 73681 49964 29450643
Drug reaction with eosinophilia and systemic symptoms 40.54 13.21 10 73910 27982 29472625
Pulmonary arteriopathy 40.11 13.21 13 73907 76 29500531
Coronary artery disease 40.11 13.21 31 73889 44159 29456448
Hyponatraemia 40.10 13.21 298 73622 67335 29433272
Nausea 40.00 13.21 975 72945 288280 29212327
Arthropathy 39.49 13.21 4 73916 21550 29479057
Drug hypersensitivity 39.44 13.21 69 73851 68337 29432270
Pneumatosis intestinalis 39.38 13.21 44 73876 3125 29497482
Respiratory failure 39.23 13.21 393 73527 96738 29403869
Disturbance in attention 39.19 13.21 4 73916 21420 29479187
Pneumonia 38.39 13.21 1059 72861 319113 29181494
Venoocclusive liver disease 38.39 13.21 65 73855 6852 29493755
Blood pressure fluctuation 38.32 13.21 3 73917 19891 29480716
Drug dependence 38.16 13.21 4 73916 20977 29479630
Polyneuropathy 38.16 13.21 90 73830 12062 29488545
Lactic acidosis 38.02 13.21 14 73906 30233 29470374
Peripheral ischaemia 38.01 13.21 55 73865 5064 29495543
Heart rate decreased 37.87 13.21 8 73912 24904 29475703
Mobility decreased 37.74 13.21 9 73911 25771 29474836
Stomatitis 37.63 13.21 188 73732 36925 29463682
Gastrooesophageal reflux disease 37.26 13.21 16 73904 31480 29469127
Somnolence 37.12 13.21 116 73804 93839 29406768
Stress 36.86 13.21 5 73915 21485 29479122
Sinusitis 36.75 13.21 20 73900 34330 29466277
Fanconi syndrome 36.52 13.21 31 73889 1567 29499040
Diarrhoea 36.46 13.21 1088 72832 331610 29168997
Tumour pseudoprogression 36.09 13.21 18 73902 358 29500249
Radiation skin injury 36.04 13.21 22 73898 658 29499949
Foetal exposure during pregnancy 35.82 13.21 20 73900 33847 29466760
Anaphylactic shock 35.78 13.21 93 73827 13243 29487364
Unevaluable event 35.57 13.21 15 73905 29836 29470771
Thrombotic microangiopathy 34.88 13.21 71 73849 8610 29491997
Diabetes mellitus 34.82 13.21 29 73891 39802 29460805
Disease recurrence 34.80 13.21 103 73817 15811 29484796
Tubulointerstitial nephritis 34.68 13.21 110 73810 17533 29483074
Gastrointestinal perforation 34.40 13.21 43 73877 3440 29497167
Disseminated intravascular coagulation 34.30 13.21 119 73801 19861 29480746
Psoriasis 34.13 13.21 19 73901 32208 29468399
Pulmonary toxicity 34.09 13.21 51 73869 4839 29495768
Body height below normal 34.01 13.21 15 73905 223 29500384
Inappropriate schedule of product administration 33.49 13.21 37 73883 44435 29456172
Histiocytic necrotising lymphadenitis 33.49 13.21 8 73912 10 29500597
Extraocular muscle disorder 33.29 13.21 14 73906 184 29500423
Juvenile melanoma benign 33.02 13.21 11 73909 71 29500536
Tracheal fistula 32.89 13.21 11 73909 72 29500535
Serotonin syndrome 32.74 13.21 3 73917 17509 29483098
Retinopathy proliferative 32.50 13.21 11 73909 75 29500532
Dyspnoea 32.21 13.21 1055 72865 325677 29174930
Bronchospasm 32.19 13.21 73 73847 9536 29491071
Paraneoplastic neurological syndrome 31.83 13.21 9 73911 30 29500577
Wrong technique in product usage process 31.22 13.21 20 73900 31408 29469199
Hypocalcaemia 31.17 13.21 118 73802 20547 29480060
Pulmonary embolism 31.05 13.21 310 73610 76224 29424383
Bicytopenia 31.04 13.21 30 73890 1797 29498810
Neoplasm recurrence 30.87 13.21 31 73889 1946 29498661
Drug level increased 30.77 13.21 5 73915 18782 29481825
Adrenocorticotropic hormone deficiency 30.69 13.21 19 73901 583 29500024
Upper respiratory tract infection 30.63 13.21 15 73905 27334 29473273
Radiation mucositis 30.52 13.21 12 73908 131 29500476
Retinal degeneration 30.51 13.21 17 73903 427 29500180
Accidental overdose 30.39 13.21 4 73916 17589 29483018
Cellulitis gangrenous 30.31 13.21 13 73907 180 29500427
Incorrect dose administered 30.10 13.21 23 73897 32961 29467646
Lymphangiosis carcinomatosa 30.10 13.21 21 73899 791 29499816
Bronchopleural fistula 30.01 13.21 17 73903 441 29500166
Delayed puberty 29.99 13.21 13 73907 185 29500422
Diffuse large B-cell lymphoma refractory 29.94 13.21 22 73898 900 29499707
Immune-mediated hepatitis 29.65 13.21 27 73893 1500 29499107
Influenza like illness 29.64 13.21 12 73908 24458 29476149
Oesophagobronchial fistula 29.36 13.21 12 73908 146 29500461
Amnesia 29.28 13.21 10 73910 22633 29477974
Treatment noncompliance 29.15 13.21 12 73908 24215 29476392
Pain 29.08 13.21 281 73639 171151 29329456
Hypopituitarism 28.63 13.21 28 73892 1702 29498905
Abnormal behaviour 28.57 13.21 11 73909 23116 29477491
Renal tubular disorder 28.37 13.21 44 73876 4308 29496299
Irritability 28.27 13.21 10 73910 22142 29478465
Lung adenocarcinoma 27.85 13.21 41 73879 3834 29496773
Fluid retention 27.81 13.21 12 73908 23548 29477059
Depressed mood 27.80 13.21 4 73916 16444 29484163
Oesophagopleural fistula 27.43 13.21 9 73911 55 29500552
Pulmonary haemorrhage 27.33 13.21 67 73853 9203 29491404
Injury 27.20 13.21 7 73913 19039 29481568
Ototoxicity 27.16 13.21 26 73894 1539 29499068
Prostate cancer 27.10 13.21 15 73905 25512 29475095
Haemolytic uraemic syndrome 26.99 13.21 29 73891 1971 29498636
Pseudocellulitis 26.96 13.21 8 73912 33 29500574
Myalgia 26.74 13.21 95 73825 73924 29426683
Product quality issue 26.55 13.21 4 73916 15891 29484716
Flatulence 26.28 13.21 6 73914 17703 29482904
Rheumatoid arthritis 26.19 13.21 25 73895 32127 29468480
Autoimmune colitis 26.09 13.21 20 73900 873 29499734
Encephalitis enteroviral 26.06 13.21 11 73909 146 29500461
Administration site extravasation 25.99 13.21 16 73904 486 29500121
Neurotoxicity 25.93 13.21 88 73832 14525 29486082
Myositis 25.85 13.21 70 73850 10213 29490394
Road traffic accident 25.80 13.21 4 73916 15557 29485050
Hypophagia 25.76 13.21 112 73808 20760 29479847
Urticaria 25.67 13.21 62 73858 54598 29446009
Optic glioma 25.56 13.21 7 73913 20 29500587
Pericarditis malignant 25.56 13.21 7 73913 20 29500587
Gastrointestinal toxicity 25.48 13.21 29 73891 2102 29498505
Nephritis 25.42 13.21 29 73891 2107 29498500
Cardiac arrest 25.20 13.21 119 73801 85472 29415135
Metastases to retroperitoneum 25.19 13.21 12 73908 215 29500392
Hyperthyroidism 25.15 13.21 62 73858 8546 29492061
Immune-mediated adverse reaction 25.08 13.21 15 73905 432 29500175
Restlessness 25.02 13.21 12 73908 22133 29478474
Myocarditis 25 13.21 72 73848 10884 29489723
Extremity necrosis 24.78 13.21 25 73895 1578 29499029
Head injury 24.78 13.21 5 73915 16076 29484531
Metastases to spleen 24.62 13.21 14 73906 366 29500241
Sleep apnoea syndrome 24.13 13.21 7 73913 17592 29483015
Hypothyroidism 24.13 13.21 91 73829 15815 29484792
Ameloblastoma 24.05 13.21 9 73911 85 29500522
Drug resistance 23.90 13.21 112 73808 21428 29479179
Tumour necrosis 23.85 13.21 21 73899 1116 29499491
Dermatitis 23.67 13.21 57 73863 7741 29492866
Haematochezia 23.47 13.21 35 73885 36948 29463659
Tumour haemorrhage 23.46 13.21 30 73890 2455 29498152
Noninfectious myelitis 23.40 13.21 6 73914 12 29500595
Nasal congestion 23.29 13.21 9 73911 18870 29481737
Short stature 23.10 13.21 8 73912 59 29500548
Psychotic disorder 23.04 13.21 11 73909 20343 29480264
Platelet count abnormal 22.76 13.21 29 73891 2365 29498242
Basal cell carcinoma 22.69 13.21 7 73913 16903 29483704
Metastases to skin 22.69 13.21 13 73907 345 29500262
Radiation dysphagia 22.63 13.21 5 73915 3 29500604
Metastases to muscle 22.46 13.21 11 73909 210 29500397
Opsoclonus myoclonus 22.43 13.21 8 73912 65 29500542
Inappropriate antidiuretic hormone secretion 22.25 13.21 69 73851 10863 29489744
Eosinophilia 22.15 13.21 14 73906 22147 29478460
Flushing 22.11 13.21 136 73784 28856 29471751
Hypertension 22.00 13.21 186 73734 116428 29384179
Pericardial effusion 21.89 13.21 108 73812 21100 29479507
Acute myelomonocytic leukaemia 21.77 13.21 9 73911 113 29500494
Vena cava thrombosis 21.75 13.21 19 73901 999 29499608
Chronic coronary syndrome 21.73 13.21 7 73913 40 29500567
Osteoarthritis 21.72 13.21 9 73911 18094 29482513
Carbamoyl phosphate synthetase deficiency 21.69 13.21 6 73914 18 29500589
Adverse drug reaction 21.60 13.21 17 73903 24003 29476604
Immune-mediated renal disorder 21.59 13.21 7 73913 41 29500566
Angioedema 21.44 13.21 29 73891 31886 29468721
Metastases to adrenals 21.43 13.21 18 73902 897 29499710
Venoocclusive disease 21.41 13.21 29 73891 2510 29498097
Contusion 21.15 13.21 28 73892 31067 29469540
Dyskinesia 20.99 13.21 12 73908 20049 29480558
Rhinorrhoea 20.95 13.21 14 73906 21505 29479102
Cerebrovascular accident 20.88 13.21 110 73810 76801 29423806
Myoclonus 20.80 13.21 4 73916 13305 29487302
Coma 20.78 13.21 42 73878 39408 29461199
Procalcitonin decreased 20.61 13.21 5 73915 7 29500600
Oesophageal fistula 20.60 13.21 10 73910 187 29500420
Oropharyngeal squamous cell carcinoma 20.51 13.21 10 73910 189 29500418
Herpes zoster reactivation 20.38 13.21 11 73909 259 29500348
Heart rate irregular 20.38 13.21 4 73916 13113 29487494
Gastrointestinal mucosal disorder 20.33 13.21 12 73908 337 29500270
Jaundice 20.32 13.21 26 73894 29270 29471337
International normalised ratio increased 20.31 13.21 51 73869 44321 29456286
Autoimmune neutropenia 20.19 13.21 11 73909 264 29500343
Gastritis bacterial 20.18 13.21 10 73910 196 29500411
Rhabdomyosarcoma recurrent 20.14 13.21 8 73912 90 29500517
Metastatic neoplasm 20.10 13.21 29 73891 2663 29497944
Metastases to lymph nodes 20.01 13.21 36 73884 3981 29496626
Metastases to pleura 19.86 13.21 12 73908 352 29500255
Chronic kidney disease 19.85 13.21 38 73882 36378 29464229
Back pain 19.80 13.21 162 73758 102122 29398485
Peripheral sensory neuropathy 19.76 13.21 45 73875 5894 29494713
Acquired tracheo-oesophageal fistula 19.72 13.21 7 73913 56 29500551
Hepatocellular injury 19.71 13.21 105 73815 21138 29479469
Surgery 19.59 13.21 3 73917 11776 29488831
Therapy cessation 19.38 13.21 6 73914 14456 29486151
Basal cell naevus syndrome 19.29 13.21 6 73914 30 29500577
Immune-mediated dermatitis 19.10 13.21 8 73912 104 29500503
Encephalopathy 19.08 13.21 138 73782 30905 29469702
Haemorrhage 18.97 13.21 54 73866 45018 29455589
Cardiac dysfunction 18.96 13.21 23 73897 1784 29498823
Hypophysitis 18.94 13.21 24 73896 1946 29498661
Hyperpyrexia 18.90 13.21 26 73894 2284 29498323
Drug intolerance 18.90 13.21 60 73860 48319 29452288
Non-small cell lung cancer recurrent 18.88 13.21 5 73915 12 29500595
Cachexia 18.83 13.21 46 73874 6303 29494304
Cytomegalovirus chorioretinitis 18.73 13.21 31 73889 3207 29497400
Sleep disorder 18.68 13.21 20 73900 24366 29476241
Hepatic steatosis 18.64 13.21 7 73913 14939 29485668
Balance disorder 18.63 13.21 39 73881 36131 29464476
Paraneoplastic syndrome 18.51 13.21 13 73907 495 29500112
Lung neoplasm malignant 18.46 13.21 78 73842 14279 29486328
Cytokine storm 18.43 13.21 14 73906 603 29500004
Secondary adrenocortical insufficiency 18.42 13.21 18 73902 1093 29499514
Hepatic function abnormal 18.39 13.21 164 73756 39095 29461512
Lung infiltration 18.38 13.21 68 73852 11711 29488896
Delusion 18.33 13.21 3 73917 11213 29489394
Iris neovascularisation 18.33 13.21 5 73915 14 29500593
B-cell lymphoma recurrent 18.31 13.21 14 73906 609 29499998
Oedema peripheral 18.28 13.21 168 73752 103389 29397218
Meningitis tuberculous 18.27 13.21 14 73906 611 29499996
Diabetes mellitus inadequate control 18.23 13.21 4 73916 12130 29488477
Emotional distress 18.20 13.21 6 73914 13889 29486718
Neuroblastoma recurrent 18.09 13.21 7 73913 73 29500534
Vasogenic cerebral oedema 18.08 13.21 13 73907 514 29500093
Wound 18.08 13.21 4 73916 12059 29488548
Performance status decreased 18.06 13.21 33 73887 3694 29496913
Angina pectoris 18.02 13.21 26 73894 27824 29472783
Erythema 17.95 13.21 277 73643 75329 29425278
Mental disorder 17.94 13.21 5 73915 12900 29487707
Oesophageal pain 17.93 13.21 15 73905 743 29499864
Iris atrophy 17.92 13.21 7 73913 75 29500532
Abdominal distension 17.89 13.21 57 73863 45854 29454753
Palpitations 17.79 13.21 34 73886 32570 29468037
Vascular access site swelling 17.75 13.21 4 73916 3 29500604
Neutropenic infection 17.72 13.21 19 73901 1288 29499319
Blood creatine phosphokinase increased 17.62 13.21 48 73872 40596 29460011
Stress cardiomyopathy 17.58 13.21 21 73899 1603 29499004
Nephropathy toxic 17.54 13.21 63 73857 10693 29489914
Cataract 17.53 13.21 18 73902 22360 29478247
Paraneoplastic rash 17.52 13.21 7 73913 80 29500527
Laboratory test abnormal 17.48 13.21 12 73908 18173 29482434
Extrapyramidal disorder 17.48 13.21 3 73917 10828 29489779
Amoebic colitis 17.44 13.21 7 73913 81 29500526
Incorrect route of product administration 17.41 13.21 3 73917 10798 29489809
Osteosarcoma 17.39 13.21 9 73911 194 29500413
Benign prostatic hyperplasia 17.31 13.21 4 73916 11706 29488901
Drug tolerance decreased 17.26 13.21 19 73901 1327 29499280
Thrombophlebitis migrans 17.22 13.21 7 73913 84 29500523
Hiccups 17.21 13.21 55 73865 8798 29491809
Bronchitis 17.17 13.21 42 73878 36826 29463781
Pruritus 17.16 13.21 198 73722 116651 29383956
Metastases to kidney 17.13 13.21 10 73910 275 29500332
Hypercreatininaemia 17.09 13.21 12 73908 457 29500150
Pulmonary arterial hypertension 17.04 13.21 49 73871 7400 29493207
Pelvic mass 17.02 13.21 9 73911 203 29500404
Vitreous haemorrhage 16.99 13.21 23 73897 1990 29498617
Lung abscess 16.96 13.21 25 73895 2341 29498266
Pulmonary hypertension 16.95 13.21 13 73907 18595 29482012
Oesophageal stenosis 16.86 13.21 20 73900 1515 29499092
Ileus 16.80 13.21 76 73844 14326 29486281
Electrolyte imbalance 16.69 13.21 64 73856 11210 29489397
Adenomatous polyposis coli 16.42 13.21 8 73912 151 29500456
Immune-mediated cholangitis 16.38 13.21 6 73914 53 29500554
Odynophagia 16.22 13.21 36 73884 4634 29495973
Blood glucose decreased 16.18 13.21 5 73915 12064 29488543
Metastasis 16.16 13.21 30 73890 3399 29497208
Angiodysplasia 16.08 13.21 12 73908 503 29500104
Renal tubular dysfunction 16.06 13.21 11 73909 402 29500205
Burning sensation 16.02 13.21 10 73910 15928 29484679
Hyperkalaemia 16.00 13.21 89 73831 61303 29439304
Metabolic acidosis 15.94 13.21 45 73875 37617 29462990
Non-small cell lung cancer metastatic 15.93 13.21 12 73908 510 29500097
Skin laceration 15.92 13.21 4 73916 11058 29489549
Retroperitoneal lymphadenopathy 15.91 13.21 14 73906 743 29499864
Lung squamous cell carcinoma metastatic 15.91 13.21 6 73914 58 29500549
Poikiloderma 15.86 13.21 8 73912 163 29500444
Transaminases increased 15.85 13.21 104 73816 22558 29478049
Fulminant type 1 diabetes mellitus 15.82 13.21 13 73907 628 29499979
Full blood count abnormal 15.68 13.21 9 73911 15004 29485603
Neuroendocrine tumour of the lung metastatic 15.64 13.21 7 73913 108 29500499
Blister 15.61 13.21 16 73904 19890 29480717
Medication error 15.58 13.21 18 73902 21193 29479414
EGFR gene mutation 15.58 13.21 7 73913 109 29500498
Asthenia 15.57 13.21 672 73248 214578 29286029
Renal salt-wasting syndrome 15.56 13.21 8 73912 170 29500437
Synovitis 15.55 13.21 4 73916 10886 29489721
Neoplasm 15.51 13.21 33 73887 4128 29496479
Pulmonary cavitation 15.51 13.21 14 73906 769 29499838
Myasthenia gravis 15.39 13.21 28 73892 3123 29497484
Blastic plasmacytoid dendritic cell neoplasia 15.39 13.21 6 73914 64 29500543
Hepatic enzyme increased 15.35 13.21 39 73881 33760 29466847
Occipital neuralgia 15.32 13.21 5 73915 30 29500577
Eyelid oedema 15.28 13.21 35 73885 4601 29496006
Small cell carcinoma 15.24 13.21 7 73913 115 29500492
Injection site erythema 15.11 13.21 8 73912 13948 29486659
Lung opacity 15.07 13.21 18 73902 1374 29499233
Blood pressure systolic increased 15.05 13.21 12 73908 16833 29483774
Subdural haematoma 14.99 13.21 14 73906 18179 29482428
Capillary leak syndrome 14.98 13.21 21 73899 1878 29498729
Arteriosclerosis coronary artery 14.95 13.21 4 73916 10601 29490006
Diabetic ketoacidosis 14.93 13.21 11 73909 16062 29484545
Pneumoperitoneum 14.87 13.21 19 73901 1554 29499053
Cholangitis 14.81 13.21 47 73873 7490 29493117
Salivary gland cancer stage IV 14.79 13.21 5 73915 34 29500573
Cardiomegaly 14.76 13.21 8 73912 13768 29486839
Malignant transformation 14.75 13.21 14 73906 820 29499787
Premature baby 14.59 13.21 13 73907 17267 29483340
Q fever 14.56 13.21 7 73913 128 29500479
Infected neoplasm 14.54 13.21 6 73914 75 29500532
Metastases to bone marrow 14.53 13.21 11 73909 471 29500136
Papilloedema 14.49 13.21 23 73897 2297 29498310
Joint stiffness 14.48 13.21 3 73917 9470 29491137
Immune thrombocytopenia 14.47 13.21 48 73872 7829 29492778
Respiratory distress 14.46 13.21 133 73787 31973 29468634
Radiation associated pain 14.46 13.21 4 73916 12 29500595
Lymph node abscess 14.46 13.21 4 73916 12 29500595
Choroidal dystrophy 14.42 13.21 5 73915 37 29500570
Chromaturia 14.36 13.21 7 73913 12795 29487812
Product administration error 14.35 13.21 9 73911 14301 29486306
Muscle rigidity 14.35 13.21 3 73917 9408 29491199
Hallucination, visual 14.31 13.21 10 73910 15005 29485602
Squamous cell carcinoma of lung 14.27 13.21 19 73901 1618 29498989
Malignant pleural effusion 14.19 13.21 17 73903 1301 29499306
Weight decreased 14.12 13.21 279 73641 150626 29349981
Photosensitivity reaction 14.01 13.21 3 73917 9255 29491352
Fanconi syndrome acquired 13.98 13.21 20 73900 1822 29498785
Frequent bowel movements 13.97 13.21 3 73917 9236 29491371
Extravasation 13.95 13.21 19 73901 1653 29498954
Nephrotic syndrome 13.87 13.21 41 73879 6287 29494320
Chorioretinal disorder 13.87 13.21 5 73915 42 29500565
Cystoid macular oedema 13.85 13.21 12 73908 624 29499983
Autoimmune pancytopenia 13.80 13.21 6 73914 86 29500521
Autoimmune haemolytic anaemia 13.75 13.21 30 73890 3818 29496789
Skin discolouration 13.74 13.21 11 73909 15398 29485209
Embolism venous 13.71 13.21 17 73903 1349 29499258
Malignant fibrous histiocytoma 13.68 13.21 6 73914 88 29500519
Urosepsis 13.52 13.21 58 73862 10688 29489919
Abdominal pain upper 13.51 13.21 93 73827 60900 29439707
Osteoporosis 13.50 13.21 5 73915 10764 29489843
Immune-mediated pancreatitis 13.47 13.21 5 73915 46 29500561
Cardiac failure 13.40 13.21 130 73790 79157 29421450
Gastric disorder 13.37 13.21 5 73915 10699 29489908
Iron deficiency anaemia 13.33 13.21 3 73917 8939 29491668
Immune-mediated encephalitis 13.32 13.21 6 73914 94 29500513

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 2075.30 11.81 2413 154347 185244 64156728
Neutropenia 1871.84 11.81 2591 154169 237033 64104939
Malignant neoplasm progression 1665.28 11.81 1691 155069 111180 64230792
Thrombocytopenia 1466.60 11.81 2228 154532 221573 64120399
Anaemia 1196.81 11.81 2755 154005 375925 63966047
Pancytopenia 1051.59 11.81 1506 155254 141803 64200169
Neutrophil count decreased 974.26 11.81 1065 155695 76131 64265841
Disease progression 894.68 11.81 1388 155372 140292 64201680
Myelosuppression 868.64 11.81 603 156157 23227 64318745
Bone marrow failure 635.19 11.81 679 156081 47273 64294699
Mucosal inflammation 624.01 11.81 765 155995 61819 64280153
Leukopenia 613.81 11.81 974 155786 100268 64241704
Erythema 607.37 11.81 1378 155382 185692 64156280
Acute myeloid leukaemia 586.33 11.81 506 156254 26957 64315015
Haematotoxicity 570.12 11.81 368 156392 12528 64329444
Neutropenic sepsis 536.17 11.81 448 156312 22824 64319148
Completed suicide 517.90 11.81 5 156755 224409 64117563
Neoplasm progression 398.94 11.81 495 156265 40469 64301503
Fall 385.17 11.81 272 156488 416554 63925418
Neuropathy peripheral 384.59 11.81 869 155891 116656 64225316
Flushing 378.68 11.81 683 156077 77965 64264007
Joint swelling 376.26 11.81 42 156718 215340 64126632
Platelet count decreased 360.11 11.81 1058 155702 166653 64175319
Myelodysplastic syndrome 355.38 11.81 385 156375 27194 64314778
Product dose omission issue 340.08 11.81 38 156722 194709 64147263
Drug ineffective 333.10 11.81 998 155762 839249 63502723
White blood cell count decreased 322.03 11.81 978 155782 156859 64185113
Metastases to central nervous system 316.66 11.81 266 156494 13646 64328326
Pain 305.37 11.81 550 156210 552961 63789011
Weight increased 299.14 11.81 75 156685 213273 64128699
Radiation pneumonitis 296.18 11.81 150 156610 3178 64338794
Nasopharyngitis 292.77 11.81 60 156700 196013 64145959
Product use in unapproved indication 291.45 11.81 1018 155742 175600 64166372
Therapy partial responder 290.85 11.81 223 156537 10025 64331947
Headache 289.42 11.81 529 156231 528938 63813034
Drug abuse 288.25 11.81 7 156753 132367 64209605
Vomiting 277.22 11.81 2284 154476 548833 63793139
Interstitial lung disease 276.55 11.81 683 156077 97049 64244923
Overdose 276.39 11.81 32 156728 159534 64182438
Metastases to liver 270.35 11.81 312 156448 23629 64318343
Rheumatoid arthritis 270 11.81 39 156721 164255 64177717
Arthralgia 267.29 11.81 414 156346 441846 63900126
Pneumonitis 265.15 11.81 455 156305 49910 64292062
Dehydration 264.14 11.81 1135 155625 215628 64126344
Ototoxicity 263.77 11.81 130 156630 2593 64339379
Anaphylactic shock 259.88 11.81 344 156416 29984 64311988
Peripheral swelling 259.63 11.81 92 156668 209061 64132911
Nausea 258.46 11.81 2978 153782 782822 63559150
Second primary malignancy 244.57 11.81 218 156542 12119 64329853
Febrile bone marrow aplasia 225.34 11.81 200 156560 11055 64330917
Sinusitis 219.15 11.81 44 156716 145884 64196088
Synovitis 216.64 11.81 5 156755 99085 64242887
Dyspnoea 214.20 11.81 2674 154086 716000 63625972
Hypokalaemia 211.74 11.81 715 156045 121188 64220784
Injection site pain 206.92 11.81 17 156743 111391 64230581
Therapeutic product effect decreased 205.15 11.81 21 156739 115330 64226642
Off label use 200.33 11.81 2382 154378 630424 63711548
Metastases to lung 196.46 11.81 213 156547 15051 64326921
Musculoskeletal stiffness 196.12 11.81 32 156728 123174 64218798
Metastases to bone 194.20 11.81 244 156516 20191 64321781
Arthropathy 184.73 11.81 35 156725 120932 64221040
General physical health deterioration 184.65 11.81 982 155778 203443 64138529
Sepsis 179.26 11.81 1063 155697 229278 64112694
Hypomagnesaemia 176.49 11.81 322 156438 37054 64304918
Contraindicated product administered 173.88 11.81 27 156733 107802 64234170
Peripheral sensory neuropathy 171.92 11.81 173 156587 11205 64330767
Condition aggravated 163.41 11.81 420 156340 372006 63969966
Depression 161.95 11.81 125 156635 183166 64158806
Pyrexia 161.49 11.81 2068 154692 556576 63785396
Colitis 158.48 11.81 403 156357 58271 64283701
Abdominal discomfort 156.49 11.81 128 156632 182194 64159778
Insomnia 156.45 11.81 150 156610 197686 64144286
Toxicity to various agents 156.38 11.81 414 156346 363099 63978873
Swelling 151.02 11.81 102 156658 160116 64181856
Skin toxicity 149.75 11.81 126 156634 6476 64335496
Haemoptysis 145.27 11.81 349 156411 48699 64293273
Drug interaction 144.16 11.81 428 156332 361655 63980317
Tumour lysis syndrome 143.19 11.81 205 156555 19235 64322737
Polyneuropathy 142.46 11.81 207 156553 19687 64322285
Pain in extremity 142.17 11.81 330 156430 302755 64039217
Gastrointestinal perforation 140.85 11.81 112 156648 5312 64336660
Suicide attempt 140.09 11.81 8 156752 70999 64270973
Proteinuria 140.05 11.81 246 156514 27477 64314495
Hepatic enzyme increased 136.08 11.81 73 156687 129870 64212102
Ovarian cancer recurrent 134.56 11.81 45 156715 304 64341668
Radiation oesophagitis 134.21 11.81 51 156709 520 64341452
Hospitalisation 132.91 11.81 14 156746 75193 64266779
Intentional product misuse 131.59 11.81 12 156748 72283 64269689
Oesophagitis 130.73 11.81 208 156552 21422 64320550
Immune-mediated lung disease 130.35 11.81 62 156698 1140 64340832
Influenza 130.16 11.81 48 156712 106483 64235489
Diarrhoea 128.44 11.81 2465 154295 720239 63621733
Decreased appetite 127.75 11.81 1141 155619 280148 64061824
Hand deformity 127.22 11.81 6 156754 62765 64279207
Aplasia 126.32 11.81 117 156643 6836 64335136
Wound 125.94 11.81 18 156742 76459 64265513
Metastases to lymph nodes 125.26 11.81 129 156631 8588 64333384
Drug intolerance 125.14 11.81 164 156596 187828 64154144
Neutropenic colitis 119.83 11.81 95 156665 4486 64337486
Glossodynia 119.76 11.81 10 156750 64686 64277286
Contusion 119.36 11.81 64 156696 113901 64228071
Muscle spasms 118.53 11.81 101 156659 140922 64201050
Choroidal infarction 118.24 11.81 35 156725 148 64341824
Posterior reversible encephalopathy syndrome 117.71 11.81 205 156555 22741 64319231
Loss of personal independence in daily activities 117.12 11.81 18 156742 72436 64269536
Pleural effusion 116.23 11.81 611 156149 125948 64216024
Metastases to meninges 113.84 11.81 76 156684 2739 64339233
Somnolence 113.09 11.81 201 156559 203444 64138528
Mobility decreased 111.24 11.81 35 156725 85805 64256167
Systemic lupus erythematosus 111.19 11.81 26 156734 77586 64264386
Septic shock 110.92 11.81 529 156231 104908 64237064
Immune-mediated enterocolitis 110.54 11.81 73 156687 2583 64339389
Injection site erythema 109.11 11.81 20 156740 70780 64271192
Bradycardia 109.07 11.81 77 156683 118142 64223830
Cardiac failure congestive 107.94 11.81 95 156665 130485 64211487
Blood cholesterol increased 107.62 11.81 3 156757 50063 64291909
Suicidal ideation 106.50 11.81 17 156743 66525 64275447
Feeling hot 106.45 11.81 297 156463 45366 64296606
Anxiety 106.35 11.81 207 156553 202442 64139530
Blood pressure fluctuation 104.98 11.81 5 156755 51866 64290106
Pneumothorax 104.31 11.81 201 156559 24097 64317875
Pulmonary embolism 103.35 11.81 659 156101 145697 64196275
Maternal exposure during pregnancy 103.15 11.81 52 156708 95832 64246140
Ileus 102.31 11.81 193 156567 22773 64319199
Cytopenia 99.36 11.81 153 156607 15318 64326654
Feeling abnormal 99.08 11.81 107 156653 133495 64208477
Stress 97.93 11.81 15 156745 60519 64281453
Abdominal pain 97.50 11.81 1174 155586 311201 64030771
Bronchospasm 95.09 11.81 181 156579 21501 64320471
Drug resistance 94.66 11.81 241 156519 34861 64307111
Recall phenomenon 94.39 11.81 47 156713 959 64341013
Disease recurrence 94.14 11.81 225 156535 31285 64310687
Migraine 93.84 11.81 19 156741 62658 64279314
Psoriasis 93.33 11.81 29 156731 71674 64270298
Drug hypersensitivity 93.18 11.81 283 156477 237532 64104440
Asthma 91.89 11.81 59 156701 95166 64246806
Exposure during pregnancy 91.56 11.81 37 156723 77638 64264334
Palmar erythema 91.22 11.81 55 156705 1655 64340317
Small intestinal perforation 90.96 11.81 64 156696 2516 64339456
EGFR gene mutation 90.95 11.81 34 156726 330 64341642
Dizziness 89.96 11.81 644 156116 429519 63912453
Blister 88.46 11.81 43 156717 80924 64261048
Memory impairment 88.43 11.81 49 156711 85633 64256339
Injury 88.05 11.81 15 156745 55977 64285995
Bronchitis 87.61 11.81 81 156679 108662 64233310
Hallucination 86.90 11.81 34 156726 72754 64269218
Electrocardiogram QT prolonged 84.09 11.81 44 156716 79404 64262568
Injection site swelling 83.64 11.81 4 156756 41349 64300623
Gait disturbance 81.79 11.81 186 156574 171969 64170003
Dysphagia 81.05 11.81 490 156270 106322 64235650
Lymphangiosis carcinomatosa 80.55 11.81 52 156708 1769 64340203
Product use issue 80.42 11.81 154 156606 151561 64190411
Drug reaction with eosinophilia and systemic symptoms 80.00 11.81 17 156743 54200 64287772
Subileus 79.49 11.81 78 156682 4899 64337073
Metastases to peritoneum 79.02 11.81 67 156693 3480 64338492
Type I hypersensitivity 78.57 11.81 67 156693 3507 64338465
Hypoglycaemia 78.46 11.81 62 156698 89830 64252142
Discomfort 78.19 11.81 50 156710 80828 64261144
Arthritis 78.08 11.81 54 156706 83760 64258212
Neurotoxicity 76.87 11.81 191 156569 27213 64314759
Thrombotic microangiopathy 76.73 11.81 142 156618 16513 64325459
Inappropriate schedule of product administration 76.42 11.81 67 156693 92219 64249753
Metastasis 75.97 11.81 81 156679 5614 64336358
Bronchial fistula 75.38 11.81 25 156735 164 64341808
Intestinal perforation 74.91 11.81 134 156626 15179 64326793
Immune-mediated hepatic disorder 74.73 11.81 33 156727 507 64341465
Irritable bowel syndrome 74.36 11.81 4 156756 37365 64304607
Heart rate decreased 73.98 11.81 21 156739 55046 64286926
Myocardial infarction 73.35 11.81 186 156574 165635 64176337
Osteoarthritis 73.30 11.81 31 156729 63305 64278667
Sedation 72.53 11.81 8 156752 41454 64300518
Retinal pigment epitheliopathy 72.26 11.81 29 156731 346 64341626
Plasma cell myeloma 71.02 11.81 13 156747 46062 64295910
Secondary cerebellar degeneration 70.38 11.81 18 156742 37 64341935
Nephrolithiasis 70.26 11.81 11 156749 43672 64298300
Metastatic neoplasm 69.80 11.81 69 156691 4373 64337599
Tremor 69.72 11.81 161 156599 148069 64193903
Hypocalcaemia 68.99 11.81 241 156519 41512 64300460
Alveolar soft part sarcoma 68.45 11.81 20 156740 80 64341892
Fibromyalgia 67.59 11.81 5 156755 35726 64306246
Rhabdomyolysis 67.40 11.81 74 156686 91652 64250320
Hypersensitivity 66.39 11.81 750 156010 195702 64146270
Tracheo-oesophageal fistula 66.22 11.81 30 156730 491 64341481
Nasal congestion 66.21 11.81 31 156729 59627 64282345
Deep vein thrombosis 66.01 11.81 460 156300 104722 64237250
Palmar-plantar erythrodysaesthesia syndrome 65.74 11.81 186 156574 28633 64313339
Disseminated intravascular coagulation 65.41 11.81 200 156560 32148 64309824
Incorrect dose administered 65.27 11.81 33 156727 60732 64281240
Diffuse large B-cell lymphoma recurrent 65.16 11.81 57 156703 3089 64338883
Malignant pleural effusion 63.96 11.81 55 156705 2912 64339060
Tachycardia 63.84 11.81 599 156161 148980 64192992
Deafness 63.59 11.81 139 156621 18220 64323752
Sense of oppression 63.22 11.81 41 156719 1406 64340566
Serotonin syndrome 62.93 11.81 10 156750 39272 64302700
Renal tubular disorder 62.55 11.81 75 156685 5912 64336060
Embolism 62.35 11.81 109 156651 12126 64329846
Drug dependence 62.06 11.81 5 156755 33307 64308665
Diabetes mellitus 61.69 11.81 43 156717 66431 64275541
Hypertransaminasaemia 60.71 11.81 81 156679 7110 64334862
Bicytopenia 60.16 11.81 58 156702 3564 64338408
Gastrooesophageal reflux disease 60.07 11.81 68 156692 83075 64258897
Anaplastic lymphoma kinase gene mutation 60.04 11.81 19 156741 105 64341867
Gastrointestinal toxicity 59.46 11.81 69 156691 5253 64336719
Large intestine perforation 58.74 11.81 108 156652 12496 64329476
Injection site reaction 58.74 11.81 20 156740 46644 64295328
Asthenia 58.26 11.81 1406 155354 426638 63915334
Acquired gene mutation 58.07 11.81 44 156716 1942 64340030
Anaphylactic reaction 57.92 11.81 324 156436 68340 64273632
Pulmonary vascular disorder 57.77 11.81 33 156727 896 64341076
Non-small cell lung cancer 57.34 11.81 65 156695 4825 64337147
Cardiotoxicity 55.59 11.81 94 156666 10180 64331792
Hyponatraemia 55.50 11.81 578 156182 147761 64194211
Immune-mediated hepatitis 55.41 11.81 47 156713 2442 64339530
Paraneoplastic neurological syndrome 54.90 11.81 15 156745 44 64341928
Coronary artery disease 54.89 11.81 40 156720 60393 64281579
Unevaluable event 54.86 11.81 27 156733 50462 64291510
Hydronephrosis 54.79 11.81 112 156648 14013 64327959
Red blood cell sedimentation rate increased 54.70 11.81 6 156754 31229 64310743
Product prescribing error 54.25 11.81 10 156750 35259 64306713
Treatment noncompliance 54.10 11.81 19 156741 43463 64298509
Lactic acidosis 54.04 11.81 42 156718 61368 64280604
Peripheral motor neuropathy 53.99 11.81 50 156710 2920 64339052
Portal venous gas 53.56 11.81 23 156737 329 64341643
Enterocolitis 53.53 11.81 101 156659 11917 64330055
Metastases to skin 53.48 11.81 37 156723 1415 64340557
Fluid retention 53.43 11.81 40 156720 59566 64282406
Hypothyroidism 53.15 11.81 217 156543 40240 64301732
Pulmonary radiation injury 52.79 11.81 15 156745 53 64341919
Muscle injury 52.07 11.81 3 156757 26434 64315538
Venoocclusive liver disease 52.04 11.81 90 156670 9925 64332047
Enterocolitis infectious 51.75 11.81 45 156715 2419 64339553
Irritability 51.27 11.81 13 156747 36733 64305239
Agitation 51.04 11.81 85 156675 88282 64253690
Upper respiratory tract infection 51.00 11.81 61 156699 72724 64269248
Duodenal ulcer perforation 50.79 11.81 11 156749 34614 64307358
Superior vena cava syndrome 50.79 11.81 32 156728 1043 64340929
Blood pressure increased 50.73 11.81 231 156529 172321 64169651
Cataract 50.50 11.81 31 156729 51231 64290741
Pulmonary arteriopathy 50.03 11.81 16 156744 92 64341880
Localised infection 49.88 11.81 7 156753 30154 64311818
Type 2 diabetes mellitus 49.51 11.81 11 156749 34009 64307963
Encephalopathy 49.24 11.81 277 156483 58542 64283430
Blood glucose increased 49.00 11.81 103 156657 97970 64244002
Administration site extravasation 48.72 11.81 31 156729 1028 64340944
Psychotic disorder 48.70 11.81 12 156748 34566 64307406
Accidental overdose 48.54 11.81 11 156749 33546 64308426
Tracheal fistula 48.37 11.81 16 156744 104 64341868
Medication error 48.14 11.81 31 156729 49935 64292037
Joint stiffness 48.12 11.81 8 156752 30396 64311576
Tumour necrosis 48.07 11.81 37 156723 1672 64340300
Amnesia 47.81 11.81 29 156731 48240 64293732
Constipation 47.75 11.81 803 155957 228534 64113438
Performance status decreased 47.72 11.81 62 156698 5302 64336670
Neutropenic infection 47.68 11.81 39 156721 1926 64340046
Pericarditis 47.52 11.81 49 156711 62467 64279505
Blood pressure systolic increased 47.21 11.81 31 156729 49422 64292550
Injection site haemorrhage 47.08 11.81 3 156757 24275 64317697
Radiation skin injury 46.90 11.81 33 156727 1297 64340675
Cardiac disorder 46.84 11.81 40 156720 55776 64286196
Respiratory failure 46.82 11.81 598 156162 160585 64181387
Osteoporosis 46.49 11.81 22 156738 42058 64299914
Haemolytic uraemic syndrome 46.39 11.81 53 156707 3968 64338004
Nervousness 46.29 11.81 8 156752 29548 64312424
Haemolytic anaemia 46.20 11.81 113 156647 15940 64326032
Neoplasm recurrence 46.07 11.81 51 156709 3688 64338284
Oesophagobronchial fistula 45.67 11.81 18 156742 204 64341768
Gastric disorder 45.51 11.81 8 156752 29189 64312783
C-reactive protein abnormal 45.19 11.81 8 156752 29039 64312933
Sleep disorder 45.16 11.81 47 156713 59662 64282310
Head injury 45.10 11.81 12 156748 32830 64309142
Influenza like illness 45.08 11.81 50 156710 61652 64280320
Papilloedema 44.93 11.81 61 156699 5444 64336528
Epistaxis 44.90 11.81 399 156361 97732 64244240
Basal cell carcinoma 44.82 11.81 10 156750 30828 64311144
Hypopituitarism 44.77 11.81 43 156717 2630 64339342
Sleep apnoea syndrome 44.74 11.81 9 156751 29823 64312149
Product quality issue 44.67 11.81 9 156751 29790 64312182
Sopor 44.38 11.81 9 156751 29652 64312320
Acute myelomonocytic leukaemia 44.30 11.81 19 156741 271 64341701
Metastases to pleura 43.74 11.81 31 156729 1233 64340739
Myositis 43.69 11.81 112 156648 16265 64325707
Surgery 43.39 11.81 8 156752 28205 64313767
Acute promyelocytic leukaemia 43.37 11.81 32 156728 1356 64340616
Rhinorrhoea 43.37 11.81 49 156711 59920 64282052
Aggression 42.77 11.81 30 156730 46202 64295770
Lower respiratory tract infection 42.69 11.81 105 156655 94509 64247463
Wheezing 42.50 11.81 82 156678 80497 64261475
Enteritis 42.47 11.81 92 156668 11985 64329987
BRCA2 gene mutation 42.32 11.81 13 156747 64 64341908
Impaired healing 42.03 11.81 51 156709 60422 64281550
Nephropathy toxic 41.88 11.81 115 156645 17399 64324573
Dermatitis 41.74 11.81 117 156643 17912 64324060
Device related thrombosis 41.63 11.81 37 156723 2048 64339924
Poisoning 41.56 11.81 3 156757 21876 64320096
Renal salt-wasting syndrome 41.54 11.81 21 156739 443 64341529
Ovarian disorder 41.50 11.81 21 156739 444 64341528
Pericardial effusion 41.28 11.81 197 156563 39057 64302915
Road traffic accident 40.79 11.81 12 156748 30733 64311239
Drug level increased 40.76 11.81 16 156744 34180 64307792
Weight decreased 40.75 11.81 471 156289 285268 64056704
Small intestinal obstruction 40.63 11.81 138 156622 23435 64318537
Tumour haemorrhage 40.23 11.81 46 156714 3447 64338525
Terminal agitation 40.18 11.81 8 156752 0 64341972
Dyskinesia 39.95 11.81 23 156737 39365 64302607
Myocarditis 39.85 11.81 111 156649 16932 64325040
Tumour pseudoprogression 39.78 11.81 21 156739 486 64341486
Extraocular muscle disorder 39.60 11.81 18 156742 297 64341675
Optic glioma 39.59 11.81 11 156749 35 64341937
Recurrent cancer 39.41 11.81 38 156722 2335 64339637
Confusional state 38.99 11.81 426 156334 260718 64081254
Emotional distress 38.06 11.81 20 156740 36018 64305954
Lymphadenopathy mediastinal 37.97 11.81 47 156713 3829 64338143
Anaphylactoid reaction 37.91 11.81 52 156708 4686 64337286
Mental disorder 37.59 11.81 9 156751 26436 64315536
Skin laceration 37.39 11.81 7 156753 24410 64317562
Device dislocation 37.26 11.81 4 156756 21174 64320798
Respiratory distress 37.11 11.81 236 156524 52095 64289877
Ascites 37.04 11.81 268 156492 61733 64280239
Metastases to spleen 37.01 11.81 20 156740 486 64341486
Thrombophlebitis migrans 37.00 11.81 17 156743 288 64341684
Pain in jaw 36.97 11.81 27 156733 40728 64301244
Nightmare 36.85 11.81 4 156756 20989 64320983
Tumour hyperprogression 36.82 11.81 14 156746 143 64341829
Peripheral ischaemia 36.81 11.81 70 156690 8308 64333664
Oropharyngeal pain 36.76 11.81 103 156657 88764 64253208
Pulmonary haemorrhage 36.38 11.81 91 156669 13018 64328954
Madarosis 36.25 11.81 36 156724 2294 64339678
Bronchopleural fistula 36.15 11.81 21 156739 589 64341383
Carbohydrate antigen 125 increased 36.10 11.81 33 156727 1895 64340077
Oxygen saturation decreased 35.63 11.81 408 156352 106768 64235204
Withdrawal syndrome 35.41 11.81 7 156753 23485 64318487
Pneumatosis intestinalis 35.40 11.81 53 156707 5176 64336796
Paraneoplastic syndrome 35.37 11.81 24 156736 889 64341083
Adverse drug reaction 35.28 11.81 35 156725 45429 64296543
International normalised ratio increased 34.83 11.81 89 156671 79078 64262894
Neutrophil count abnormal 34.82 11.81 39 156721 2857 64339115
Immune-mediated pancreatitis 34.46 11.81 12 156748 93 64341879
Coma 34.45 11.81 104 156656 87511 64254461
Rectal perforation 34.35 11.81 22 156738 738 64341234
Cholangitis 34.29 11.81 79 156681 10723 64331249
Cerebrovascular accident 34.29 11.81 195 156565 137388 64204584
Joint injury 34.25 11.81 7 156753 22940 64319032
Balance disorder 34.18 11.81 98 156662 83828 64258144
Ovarian epithelial cancer recurrent 34.17 11.81 8 156752 9 64341963
Hepatic function abnormal 33.93 11.81 270 156490 64043 64277929
Metastases to retroperitoneum 33.74 11.81 17 156743 356 64341616
Full blood count abnormal 33.74 11.81 15 156745 29742 64312230
Hyperpyrexia 33.72 11.81 51 156709 5026 64336946
Hypoalbuminaemia 33.62 11.81 107 156653 17567 64324405
Aortitis 33.54 11.81 25 156735 1076 64340896
Adrenal insufficiency 33.08 11.81 125 156635 22362 64319610
Foot fracture 33.07 11.81 3 156757 18154 64323818
Metastases to kidney 33.03 11.81 18 156742 445 64341527
Hypophysitis 33.02 11.81 42 156718 3517 64338455
Dysstasia 32.80 11.81 8 156752 23207 64318765
Onycholysis 32.75 11.81 29 156731 1597 64340375
Delusion 32.75 11.81 3 156757 18011 64323961
Product substitution issue 32.40 11.81 3 156757 17858 64324114
Fanconi syndrome 32.35 11.81 35 156725 2466 64339506
Treatment failure 32.20 11.81 160 156600 116656 64225316
Metastases to adrenals 31.83 11.81 25 156735 1164 64340808
Kounis syndrome 31.77 11.81 38 156722 2987 64338985
Liver function test abnormal 31.71 11.81 60 156700 59341 64282631
Cancer pain 31.50 11.81 45 156715 4212 64337760
Bursitis 31.16 11.81 7 156753 21478 64320494
Adverse event 31.10 11.81 30 156730 39459 64302513
Cachexia 31.03 11.81 69 156691 9148 64332824
Abnormal behaviour 30.86 11.81 22 156738 33600 64308372
Haemorrhage 30.62 11.81 95 156665 79256 64262716
Fear 30.43 11.81 6 156754 20165 64321807
Alopecia areata 30.28 11.81 27 156733 1501 64340471
Crying 30.25 11.81 6 156754 20084 64321888
Extravasation 30.25 11.81 38 156722 3142 64338830
Urosepsis 30.21 11.81 120 156640 21974 64319998
Panic attack 30.04 11.81 7 156753 20946 64321026
Laryngeal cancer stage III 29.93 11.81 8 156752 21 64341951
Blood triglycerides increased 29.78 11.81 5 156755 18861 64323111
Inappropriate antidiuretic hormone secretion 29.63 11.81 120 156640 22169 64319803
Iris atrophy 29.59 11.81 11 156749 105 64341867
Abortion spontaneous 29.58 11.81 12 156748 25131 64316841
Anastomotic leak 29.58 11.81 22 156738 944 64341028
Vision blurred 29.56 11.81 116 156644 90200 64251772
Adrenocorticotropic hormone deficiency 29.54 11.81 21 156739 839 64341133
Myoclonus 29.53 11.81 12 156748 25106 64316866
Paraesthesia 29.44 11.81 475 156285 134047 64207925
Retinopathy proliferative 29.40 11.81 11 156749 107 64341865
Wrong technique in product usage process 29.39 11.81 72 156688 64902 64277070
Chest discomfort 29.28 11.81 420 156340 115686 64226286
Immune-mediated dermatitis 29.19 11.81 12 156748 153 64341819
Capillary leak syndrome 29.16 11.81 38 156722 3259 64338713
Acoustic stimulation tests abnormal 29.15 11.81 8 156752 24 64341948
Extrapyramidal disorder 29.11 11.81 6 156754 19546 64322426
Mood swings 29.01 11.81 4 156756 17464 64324508
Viral infection 29.00 11.81 27 156733 36113 64305859
Hypertensive crisis 29.00 11.81 104 156656 18144 64323828
Electrolyte imbalance 28.99 11.81 130 156630 25113 64316859
Venous thrombosis 28.88 11.81 54 156706 6327 64335645
Musculoskeletal pain 28.84 11.81 101 156659 81193 64260779
Eosinophilia 28.76 11.81 30 156730 38046 64303926
Prescribed overdose 28.74 11.81 7 156753 20324 64321648
Ulcer 28.68 11.81 10 156750 22980 64318992
Throat tightness 28.67 11.81 122 156638 23038 64318934
Joint range of motion decreased 28.67 11.81 6 156754 19337 64322635
Cardiac arrest 28.65 11.81 238 156522 153826 64188146
Sciatica 28.60 11.81 7 156753 20257 64321715
Hallucination, visual 28.59 11.81 16 156744 27818 64314154
Immune-mediated renal disorder 28.55 11.81 9 156751 49 64341923
Oesophagopleural fistula 28.55 11.81 9 156751 49 64341923
Radiation mucositis 28.50 11.81 12 156748 163 64341809
Malignant transformation 28.43 11.81 23 156737 1118 64340854
Product administration error 28.24 11.81 16 156744 27627 64314345
Flatulence 28.20 11.81 27 156733 35639 64306333
Colitis ischaemic 28.11 11.81 84 156676 13330 64328642
Obstructive shock 28.10 11.81 9 156751 52 64341920
Limb injury 28.01 11.81 11 156749 23494 64318478
Hypervolaemia 27.99 11.81 31 156729 38254 64303718
Vitreous haemorrhage 27.98 11.81 36 156724 3049 64338923
Histiocytic necrotising lymphadenitis 27.96 11.81 9 156751 53 64341919
Transfusion 27.90 11.81 5 156755 17989 64323983
Hallucination, auditory 27.85 11.81 4 156756 16935 64325037
Nephritis 27.66 11.81 39 156721 3607 64338365
Therapy cessation 27.60 11.81 23 156737 32466 64309506
Subdural haematoma 27.58 11.81 17 156743 28037 64313935
Pseudocirrhosis 27.50 11.81 18 156742 627 64341345
Tubulointerstitial nephritis 27.50 11.81 148 156612 30761 64311211
Hypersomnia 27.46 11.81 7 156753 19710 64322262
Dysaesthesia 27.42 11.81 46 156714 4949 64337023
Obesity 27.32 11.81 8 156752 20554 64321418
Autoimmune haemolytic anaemia 27.32 11.81 56 156704 7020 64334952
Hepatocellular injury 27.29 11.81 196 156564 45039 64296933
Muscle spasticity 27.26 11.81 4 156756 16665 64325307
Neck pain 27.20 11.81 69 156691 61464 64280508
Arteriosclerosis coronary artery 27.15 11.81 3 156757 15526 64326446
Hypertension 27.02 11.81 823 155937 258438 64083534
Swollen tongue 27.02 11.81 27 156733 34927 64307045
Hyperlipidaemia 26.98 11.81 11 156749 22965 64319007
Platelet count abnormal 26.87 11.81 41 156719 4071 64337901
Endocarditis noninfective 26.85 11.81 12 156748 190 64341782
Haematochezia 26.66 11.81 78 156682 66295 64275677
Encephalitis enteroviral 26.63 11.81 11 156749 142 64341830
Extremity necrosis 26.54 11.81 33 156727 2701 64339271
Chills 26.51 11.81 475 156285 136789 64205183
Skin reaction 26.50 11.81 78 156682 12274 64329698
Immune-mediated cholangitis 26.31 11.81 10 156750 102 64341870
Lung adenocarcinoma 26.29 11.81 54 156706 6779 64335193
Metastases to spine 26.21 11.81 38 156722 3605 64338367
Gait inability 26.12 11.81 39 156721 42329 64299643
Dermatitis acneiform 25.98 11.81 61 156699 8382 64333590
Skin candida 25.92 11.81 26 156734 1677 64340295
Hyperthyroidism 25.88 11.81 100 156660 18079 64323893
Tooth disorder 25.86 11.81 11 156749 22391 64319581
Embolism venous 25.85 11.81 37 156723 3470 64338502
Upper limb fracture 25.67 11.81 3 156757 14863 64327109
Right ventricular failure 25.67 11.81 10 156750 21461 64320511
Leukoencephalopathy 25.56 11.81 54 156706 6913 64335059
Acute megakaryocytic leukaemia 25.51 11.81 6 156754 7 64341965
Abdominal distension 25.03 11.81 134 156626 95860 64246112
Osteosarcoma 24.94 11.81 13 156747 293 64341679
Underdose 24.91 11.81 16 156744 25813 64316159
Iron deficiency anaemia 24.87 11.81 11 156749 21878 64320094
Device issue 24.77 11.81 12 156748 22636 64319336
Oesophageal fistula 24.74 11.81 13 156747 298 64341674
Procedural pain 24.72 11.81 4 156756 15504 64326468
Immune-mediated adverse reaction 24.68 11.81 18 156742 749 64341223
Eastern Cooperative Oncology Group performance status worsened 24.63 11.81 22 156738 1226 64340746
Myelitis 24.62 11.81 28 156732 2086 64339886
Rash maculo-papular 24.57 11.81 197 156563 46829 64295143
Therapy interrupted 24.51 11.81 9 156751 20027 64321945
Autoimmune colitis 24.48 11.81 23 156737 1368 64340604
Tumour embolism 24.36 11.81 10 156750 127 64341845
Pulmonary toxicity 24.36 11.81 60 156700 8501 64333471
Visual impairment 24.33 11.81 95 156665 73982 64267990
Breast cancer 24.32 11.81 21 156739 29127 64312845
Ameloblastoma 24.29 11.81 9 156751 85 64341887
Cholelithiasis 24.26 11.81 46 156714 45460 64296512
Pelvic abscess 24.18 11.81 26 156734 1819 64340153
Rash pruritic 24.13 11.81 66 156694 57338 64284634
Systemic infection 24.00 11.81 40 156720 4281 64337691
Pericarditis malignant 23.96 11.81 7 156753 28 64341944
Iris neovascularisation 23.93 11.81 8 156752 54 64341918
Pseudocellulitis 23.93 11.81 8 156752 54 64341918
Metaplasia 23.90 11.81 14 156746 399 64341573
Gastrointestinal haemorrhage 23.88 11.81 206 156554 132106 64209866
Urogenital fistula 23.84 11.81 9 156751 90 64341882
Splenic artery thrombosis 23.80 11.81 8 156752 55 64341917
Kidney infection 23.59 11.81 7 156753 17831 64324141
Femur fracture 23.49 11.81 29 156731 34106 64307866
Tendonitis 23.35 11.81 10 156750 20272 64321700
Cholangitis sclerosing 23.34 11.81 26 156734 1893 64340079
Respiratory depression 23.33 11.81 14 156746 23429 64318543
Retroperitoneal lymphadenopathy 23.29 11.81 19 156741 935 64341037
Agranulocytosis 23.26 11.81 166 156594 38063 64303909
Cystoid macular oedema 23.25 11.81 25 156735 1749 64340223
Cellulitis gangrenous 23.12 11.81 12 156748 268 64341704
Injection site rash 23.09 11.81 5 156755 15737 64326235
Incorrect route of product administration 23.07 11.81 14 156746 23284 64318688
Rib fracture 23.03 11.81 15 156745 24023 64317949
Lung cancer metastatic 22.95 11.81 33 156727 3107 64338865
Immune-mediated encephalitis 22.88 11.81 12 156748 274 64341698
Hepatotoxicity 22.87 11.81 171 156589 39791 64302181
Radiation dysphagia 22.77 11.81 5 156755 3 64341969
Dermatomyositis 22.76 11.81 31 156729 2775 64339197
Depressed level of consciousness 22.75 11.81 111 156649 81325 64260647
Hyperkalaemia 22.74 11.81 148 156612 100981 64240991
Acne 22.67 11.81 14 156746 23067 64318905
Hyperhidrosis 22.63 11.81 428 156332 124492 64217480
Injection site warmth 22.55 11.81 3 156757 13459 64328513
Subacute cutaneous lupus erythematosus 22.42 11.81 32 156728 2993 64338979
Paranoia 22.40 11.81 6 156754 16346 64325626
Faecaloma 22.39 11.81 63 156697 9665 64332307
Oral herpes 22.37 11.81 13 156747 22139 64319833
Metastases to bladder 22.29 11.81 11 156749 220 64341752
Diabetes mellitus inadequate control 22.27 11.81 12 156748 21309 64320663
Depressed mood 22.27 11.81 41 156719 40971 64301001
Guillain-Barre syndrome 22.24 11.81 54 156706 7581 64334391
Bladder perforation 22.19 11.81 12 156748 292 64341680
Immune-mediated hypothyroidism 22.17 11.81 10 156750 162 64341810
Hip fracture 22.03 11.81 20 156740 27079 64314893
Respiratory tract congestion 22.02 11.81 6 156754 16159 64325813
Nail disorder 22.00 11.81 58 156702 8566 64333406
Impaired work ability 21.99 11.81 5 156755 15214 64326758
Musculoskeletal disorder 21.97 11.81 8 156752 17898 64324074
Palpitations 21.97 11.81 156 156604 104332 64237640
Hypotension 21.94 11.81 1134 155626 379840 63962132
Chronic coronary syndrome 21.92 11.81 7 156753 40 64341932
Hypoxia 21.87 11.81 318 156442 87831 64254141
Carbamoyl phosphate synthetase deficiency 21.86 11.81 6 156754 18 64341954
Glycosylated haemoglobin increased 21.72 11.81 6 156754 16013 64325959
Oedema peripheral 21.65 11.81 370 156390 209947 64132025
Noninfectious myelitis 21.62 11.81 6 156754 19 64341953
Cellulitis 21.61 11.81 136 156624 93521 64248451
Eye excision 21.55 11.81 8 156752 76 64341896
Administration related reaction 21.39 11.81 9 156751 122 64341850
Bone marrow infiltration 21.38 11.81 14 156746 488 64341484
Hypophagia 21.32 11.81 167 156593 39420 64302552
Acquired tracheo-oesophageal fistula 21.28 11.81 8 156752 79 64341893
B-cell lymphoma recurrent 21.22 11.81 17 156743 815 64341157
Oropharyngeal squamous cell carcinoma 21.18 11.81 11 156749 246 64341726
Pancreatitis 21.18 11.81 74 156686 59533 64282439
Gastrointestinal necrosis 21.06 11.81 41 156719 4951 64337021
Venoocclusive disease 20.95 11.81 36 156724 3949 64338023
Faeces discoloured 20.91 11.81 19 156741 25710 64316262
Metabolic acidosis 20.83 11.81 95 156665 70863 64271109
Gastroenteritis viral 20.76 11.81 11 156749 19718 64322254
Procalcitonin decreased 20.75 11.81 5 156755 7 64341965
Transient ischaemic attack 20.74 11.81 48 156712 44134 64297838
Metastases to the mediastinum 20.60 11.81 14 156746 520 64341452
Haemoglobin 20.59 11.81 8 156752 87 64341885
Diffuse large B-cell lymphoma refractory 20.58 11.81 19 156741 1105 64340867
Night sweats 20.50 11.81 35 156725 36011 64305961
Glioma 20.45 11.81 14 156746 526 64341446
Hepatitis B reactivation 20.44 11.81 40 156720 4849 64337123
Fracture 20.42 11.81 10 156750 18745 64323227
Stress cardiomyopathy 20.38 11.81 59 156701 9198 64332774
Double hit lymphoma 20.34 11.81 6 156754 25 64341947
Cyanosis 20.33 11.81 107 156653 22048 64319924
Folliculitis 20.23 11.81 26 156734 30051 64311921
Carcinoid crisis 20.17 11.81 13 156747 441 64341531
Blood glucose decreased 20.10 11.81 16 156744 23107 64318865
Heat cramps 20.09 11.81 4 156756 0 64341972
Delayed puberty 19.99 11.81 9 156751 145 64341827
Rhabdomyosarcoma recurrent 19.97 11.81 8 156752 95 64341877
Non-small cell lung cancer recurrent 19.91 11.81 7 156753 56 64341916
Pulmonary oedema 19.87 11.81 111 156649 78563 64263409
Lung squamous cell carcinoma metastatic 19.80 11.81 7 156753 57 64341915
Chromosomal mutation 19.79 11.81 6 156754 28 64341944
Disability 19.72 11.81 3 156757 12169 64329803
Sinus bradycardia 19.70 11.81 16 156744 22877 64319095
Spinal cord infarction 19.68 11.81 14 156746 560 64341412
Hepatic steatosis 19.65 11.81 28 156732 30979 64310993
Blood urine present 19.63 11.81 10 156750 18330 64323642
Tumour associated fever 19.57 11.81 14 156746 565 64341407
Infected lymphocele 19.57 11.81 10 156750 216 64341756
Muscle rigidity 19.51 11.81 9 156751 17464 64324508
Small cell lung cancer 19.50 11.81 28 156732 2633 64339339
Emphysematous cystitis 19.48 11.81 10 156750 218 64341754
Basal cell naevus syndrome 19.46 11.81 6 156754 30 64341942
Prostate cancer 19.45 11.81 12 156748 19783 64322189
Gastropleural fistula 19.39 11.81 7 156753 61 64341911
Urticaria 19.38 11.81 247 156513 147070 64194902
Bronchostenosis 19.36 11.81 14 156746 575 64341397
Oesophageal stenosis 19.33 11.81 34 156726 3800 64338172
Small cell carcinoma 19.31 11.81 11 156749 297 64341675
Poor quality sleep 19.31 11.81 11 156749 18940 64323032
Herpes zoster 19.31 11.81 113 156647 79074 64262898
Laryngospasm 19.28 11.81 32 156728 3413 64338559
Pulmonary cavitation 19.25 11.81 20 156740 1345 64340627
Eye disorder 19.16 11.81 11 156749 18858 64323114
Hypoaesthesia 19.14 11.81 231 156529 138877 64203095
Medulloblastoma recurrent 19.05 11.81 8 156752 108 64341864
Ankle fracture 19.05 11.81 6 156754 14704 64327268
Stem cell transplant 19.03 11.81 32 156728 3449 64338523
Prescribed underdose 19.02 11.81 10 156750 18005 64323967
Metastases to abdominal cavity 19.00 11.81 13 156747 488 64341484
Disturbance in attention 18.98 11.81 45 156715 41029 64300943
Lymphadenopathy 18.92 11.81 185 156575 46501 64295471
Diabetic ketoacidosis 18.86 11.81 27 156733 29818 64312154
Vasogenic cerebral oedema 18.75 11.81 17 156743 966 64341006
Metastases to muscle 18.73 11.81 11 156749 315 64341657
Radiation injury 18.72 11.81 15 156745 719 64341253
Non-small cell lung cancer metastatic 18.67 11.81 16 156744 843 64341129
Scleroderma-like reaction 18.66 11.81 8 156752 114 64341858
Eye pain 18.65 11.81 30 156730 31595 64310377
Bacterial tracheitis 18.55 11.81 6 156754 36 64341936
Lung abscess 18.47 11.81 32 156728 3534 64338438
Angiodermatitis 18.37 11.81 7 156753 72 64341900
Joint effusion 18.35 11.81 5 156755 13468 64328504
Ocular vascular disorder 18.34 11.81 12 156748 418 64341554
Hair texture abnormal 18.30 11.81 29 156731 2975 64338997
Jaw operation 18.28 11.81 15 156745 744 64341228
Drug level decreased 18.26 11.81 3 156757 11500 64330472
Ureteric fistula 18.22 11.81 5 156755 15 64341957
Mood altered 18.20 11.81 8 156752 15971 64326001
Joint dislocation 18.18 11.81 3 156757 11462 64330510
Product dispensing error 18.15 11.81 3 156757 11447 64330525
Burning sensation 18.09 11.81 61 156699 49603 64292369
Female genital tract fistula 18.08 11.81 27 156733 2631 64339341
BRAF V600E mutation positive 18.01 11.81 6 156754 40 64341932
Pruritus 17.99 11.81 930 155830 311470 64030502
Growth hormone deficiency 17.98 11.81 11 156749 340 64341632
Malignant ascites 17.96 11.81 17 156743 1021 64340951
Intestinal obstruction 17.87 11.81 150 156610 36136 64305836
Eyelid oedema 17.85 11.81 68 156692 12211 64329761
Hypokinesia 17.84 11.81 9 156751 16587 64325385
Empyema 17.83 11.81 32 156728 3633 64338339
Obstructive airways disorder 17.81 11.81 18 156742 23167 64318805
Hypophosphataemia 17.80 11.81 77 156683 14643 64327329
Dysarthria 17.76 11.81 79 156681 59327 64282645
Transaminases increased 17.73 11.81 176 156584 44418 64297554
Paraneoplastic rash 17.71 11.81 7 156753 80 64341892
Immune-mediated myocarditis 17.67 11.81 12 156748 445 64341527
Retinal degeneration 17.56 11.81 17 156743 1050 64340922
Ill-defined disorder 17.52 11.81 52 156708 44000 64297972
Blood creatine phosphokinase increased 17.43 11.81 78 156682 58480 64283492
Amoebic colitis 17.40 11.81 7 156753 84 64341888
Blood loss anaemia 17.40 11.81 6 156754 13886 64328086
Fulminant type 1 diabetes mellitus 17.39 11.81 17 156743 1063 64340909
Heavy menstrual bleeding 17.38 11.81 4 156756 12073 64329899
Scintillating scotoma 17.34 11.81 9 156751 201 64341771
Optic atrophy 17.25 11.81 21 156739 1682 64340290
Shock 17.23 11.81 155 156605 38085 64303887
Lymph node abscess 17.18 11.81 6 156754 47 64341925
Gout 17.18 11.81 16 156744 21397 64320575
Sinus congestion 17.16 11.81 8 156752 15431 64326541
Thrombocytopenia neonatal 17.11 11.81 5 156755 20 64341952
White blood cell count abnormal 17.09 11.81 37 156723 4817 64337155
Hip arthroplasty 17.07 11.81 16 156744 21335 64320637
Eyelid rash 16.97 11.81 7 156753 90 64341882
Sinus disorder 16.96 11.81 10 156750 16898 64325074
Urinary tract obstruction 16.96 11.81 33 156727 3984 64337988
Nervous system disorder 16.93 11.81 105 156655 22973 64318999
Head discomfort 16.87 11.81 4 156756 11830 64330142
Blast cells present 16.87 11.81 15 156745 831 64341141
Choroidal dystrophy 16.85 11.81 6 156754 50 64341922
Sneezing 16.80 11.81 8 156752 15243 64326729
Abdominal compartment syndrome 16.77 11.81 19 156741 1409 64340563
Myeloid leukaemia 16.75 11.81 13 156747 595 64341377
Laryngeal discomfort 16.72 11.81 12 156748 487 64341485
Haemoglobin decreased 16.66 11.81 605 156155 194458 64147514
Spinal fracture 16.66 11.81 8 156752 15166 64326806
Seasonal allergy 16.65 11.81 4 156756 11722 64330250
Blood pressure diastolic increased 16.64 11.81 3 156757 10749 64331223
Spinal osteoarthritis 16.62 11.81 7 156753 14334 64327638
Gastrointestinal disorder 16.48 11.81 139 156621 89570 64252402
Vascular access site swelling 16.44 11.81 4 156756 6 64341966
Endometrial cancer recurrent 16.44 11.81 4 156756 6 64341966
Carpal tunnel syndrome 16.40 11.81 9 156751 15819 64326153
Pulmonary hypertension 16.39 11.81 52 156708 43087 64298885
BRCA1 gene mutation 16.38 11.81 5 156755 24 64341948
Gastritis bacterial 16.35 11.81 10 156750 309 64341663
Intervertebral disc protrusion 16.30 11.81 15 156745 20176 64321796
Thinking abnormal 16.29 11.81 4 156756 11552 64330420
Photophobia 16.29 11.81 11 156749 17282 64324690
Failure to thrive 16.28 11.81 59 156701 10345 64331627
Cytotoxic oedema 16.26 11.81 10 156750 312 64341660
Autoimmune neutropenia 16.22 11.81 11 156749 407 64341565
Hair colour changes 16.20 11.81 31 156729 3696 64338276
Miosis 16.16 11.81 6 156754 13260 64328712
Vaginal cuff dehiscence 16.06 11.81 4 156756 7 64341965
Metastases to breast 16.04 11.81 9 156751 236 64341736
Fatigue 16.02 11.81 1585 155175 747145 63594827
Glaucoma 15.94 11.81 10 156750 16338 64325634
Squamous cell carcinoma of lung 15.93 11.81 22 156738 1996 64339976
Intervertebral disc degeneration 15.87 11.81 6 156754 13114 64328858
Limb discomfort 15.81 11.81 26 156734 27149 64314823
Neuroendocrine tumour of the lung metastatic 15.77 11.81 7 156753 109 64341863
Coronary artery occlusion 15.75 11.81 7 156753 13884 64328088
Eyelid ptosis 15.75 11.81 55 156705 9470 64332502
Metastases to bone marrow 15.67 11.81 13 156747 655 64341317
Neoplasm 15.66 11.81 45 156715 6986 64334986
Ear pain 15.63 11.81 23 156737 25113 64316859
Laryngeal necrosis 15.60 11.81 5 156755 29 64341943
Cold sweat 15.46 11.81 80 156680 16375 64325597
Duodenal perforation 15.43 11.81 21 156739 1879 64340093
Peritonitis 15.42 11.81 109 156651 24914 64317058
Colitis ulcerative 15.39 11.81 20 156740 23008 64318964
Neuroblastoma recurrent 15.38 11.81 6 156754 66 64341906
Cerebral infarction 15.36 11.81 160 156600 40884 64301088
Hot flush 15.35 11.81 176 156584 46059 64295913
Eye swelling 15.26 11.81 19 156741 22262 64319710
Epstein Barr virus positive mucocutaneous ulcer 15.19 11.81 13 156747 684 64341288
Ovarian cyst 15.18 11.81 4 156756 11014 64330958
Metastases to abdominal wall 15.16 11.81 7 156753 120 64341852
Breast cancer metastatic 15.12 11.81 45 156715 7124 64334848
Opsoclonus myoclonus 15.12 11.81 8 156752 186 64341786
Infantile vomiting 15.07 11.81 3 156757 0 64341972
Metastatic choriocarcinoma 15.07 11.81 3 156757 0 64341972
Hernia 15.03 11.81 7 156753 13511 64328461
Adenomatous polyposis coli 15.01 11.81 8 156752 189 64341783
Adenocarcinoma of appendix 14.99 11.81 6 156754 71 64341901
Dementia 14.98 11.81 17 156743 20749 64321223
Barotrauma 14.97 11.81 8 156752 190 64341782
Vena cava thrombosis 14.96 11.81 24 156736 2488 64339484
Bone density decreased 14.93 11.81 3 156757 9949 64332023
Malignant fibrous histiocytoma 14.92 11.81 6 156754 72 64341900
Aorto-oesophageal fistula 14.92 11.81 6 156754 72 64341900
Ovarian cancer 14.91 11.81 28 156732 3291 64338681
Emotional disorder 14.86 11.81 6 156754 12601 64329371
Arterioenteric fistula 14.83 11.81 4 156756 11 64341961
Hiatus hernia 14.76 11.81 16 156744 19941 64322031
Myalgia 14.75 11.81 284 156476 158333 64183639
VIth nerve paralysis 14.72 11.81 18 156742 1448 64340524
Abdominal abscess 14.68 11.81 41 156719 6263 64335709
Skin hyperpigmentation 14.66 11.81 42 156718 6509 64335463
Eosinophil count increased 14.66 11.81 8 156752 14104 64327868
Odynophagia 14.52 11.81 54 156706 9587 64332385
Metastases to chest wall 14.49 11.81 10 156750 381 64341591
Therapeutic response unexpected 14.49 11.81 12 156748 16989 64324983
Mechanical ileus 14.47 11.81 12 156748 604 64341368
Cardiac murmur 14.47 11.81 5 156755 11558 64330414
Breast cancer recurrent 14.46 11.81 24 156736 2559 64339413
Retinal toxicity 14.45 11.81 17 156743 1313 64340659
Uterine adhesions 14.44 11.81 5 156755 38 64341934
Upper gastrointestinal haemorrhage 14.43 11.81 41 156719 35179 64306793
Hiccups 14.40 11.81 49 156711 8327 64333645
Akathisia 14.37 11.81 5 156755 11505 64330467
Ejection fraction decreased 14.31 11.81 119 156641 28588 64313384
Gastric neoplasm 14.29 11.81 9 156751 293 64341679
Respiratory fatigue 14.25 11.81 8 156752 210 64341762
Pulmonary alveolar haemorrhage 14.21 11.81 54 156706 9684 64332288
Meningitis herpes 14.21 11.81 8 156752 211 64341761
Pollakiuria 14.21 11.81 35 156725 31495 64310477
Infusion site oedema 14.19 11.81 12 156748 621 64341351
Speech disorder 14.13 11.81 65 156695 48376 64293596
Malignant peritoneal neoplasm 14.09 11.81 12 156748 627 64341345
Cystitis haemorrhagic 14.08 11.81 47 156713 7909 64334063
Blood potassium increased 14.08 11.81 26 156734 25954 64316018
Pelvic infection 14.00 11.81 9 156751 304 64341668
Kidney transplant rejection 13.99 11.81 3 156757 9508 64332464
Inflammation 13.96 11.81 97 156663 65203 64276769
Dry mouth 13.80 11.81 88 156672 60330 64281642
Respiratory arrest 13.79 11.81 74 156686 52911 64289061
Pneumoretroperitoneum 13.78 11.81 6 156754 89 64341883
Eye irritation 13.75 11.81 11 156749 15845 64326127
Gastric perforation 13.74 11.81 28 156732 3495 64338477
Cardiac dysfunction 13.70 11.81 26 156734 3080 64338892
Anal sphincter atony 13.69 11.81 9 156751 316 64341656
Necrotising colitis 13.62 11.81 14 156746 930 64341042
Ovarian failure 13.61 11.81 11 156749 534 64341438
Metastases to vagina 13.50 11.81 4 156756 17 64341955
Increased tendency to bruise 13.45 11.81 3 156757 9252 64332720
Increased appetite 13.39 11.81 4 156756 10142 64331830
Systemic scleroderma 13.38 11.81 14 156746 949 64341023
Granulocyte count decreased 13.35 11.81 16 156744 1260 64340712
Scar 13.34 11.81 8 156752 13390 64328582
Aortic dissection rupture 13.31 11.81 4 156756 18 64341954
Thirst 13.30 11.81 9 156751 14128 64327844
Pharyngitis 13.28 11.81 16 156744 19023 64322949
Melaena 13.27 11.81 76 156684 53472 64288500
Mania 13.26 11.81 12 156748 16274 64325698
Retroperitoneal abscess 13.22 11.81 9 156751 335 64341637
Muscle twitching 13.22 11.81 16 156744 18982 64322990
Neoplasm malignant 13.21 11.81 104 156656 24584 64317388
Thyroiditis 13.19 11.81 28 156732 3596 64338376
Spinal cord compression 13.19 11.81 37 156723 5666 64336306
Clostridium difficile colitis 13.12 11.81 112 156648 27111 64314861
Lymphocele 13.12 11.81 18 156742 1623 64340349
Laboratory test abnormal 13.11 11.81 24 156736 24039 64317933
Neutrophil count 13.07 11.81 7 156753 167 64341805
Ligament sprain 13.06 11.81 5 156755 10847 64331125
Vaginal perforation 12.99 11.81 3 156757 3 64341969
Maximal voluntary ventilation abnormal 12.99 11.81 3 156757 3 64341969
Photosensitivity reaction 12.97 11.81 15 156745 18158 64323814
Tumour invasion 12.97 11.81 9 156751 346 64341626
Fanconi syndrome acquired 12.90 11.81 22 156738 2399 64339573
Orthostatic hypotension 12.88 11.81 64 156696 46674 64295298
Lung infiltration 12.88 11.81 91 156669 20798 64321174
Blood lactate dehydrogenase increased 12.88 11.81 130 156630 32948 64309024
Pulmonary congestion 12.85 11.81 24 156736 23856 64318116
Angina pectoris 12.85 11.81 61 156699 45020 64296952
Tooth infection 12.82 11.81 10 156750 14591 64327381
Hepatic cirrhosis 12.81 11.81 28 156732 26270 64315702
Intestinal metastasis 12.80 11.81 8 156752 257 64341715
Laryngeal leukoplakia 12.74 11.81 5 156755 56 64341916
No adverse event 12.64 11.81 32 156728 28529 64313443
Autoimmune myocarditis 12.61 11.81 8 156752 264 64341708
Cardiomegaly 12.57 11.81 24 156736 23660 64318312
Psychomotor hyperactivity 12.56 11.81 10 156750 14441 64327531
Feeling cold 12.56 11.81 24 156736 23654 64318318
Gene mutation 12.55 11.81 20 156740 2062 64339910
Cytokine storm 12.51 11.81 13 156747 874 64341098
CSF white blood cell count decreased 12.51 11.81 4 156756 23 64341949
Pelvic fracture 12.49 11.81 5 156755 10558 64331414
Lupus-like syndrome 12.48 11.81 3 156757 8788 64333184
Pseudomembranous colitis 12.48 11.81 33 156727 4883 64337089
Lichenoid keratosis 12.42 11.81 26 156734 3308 64338664
Lung neoplasm malignant 12.40 11.81 92 156668 21356 64320616
Infusion site thrombosis 12.39 11.81 7 156753 186 64341786
Anaphylactoid shock 12.38 11.81 12 156748 742 64341230
Rotator cuff syndrome 12.38 11.81 7 156753 12100 64329872
Blood pressure diastolic decreased 12.37 11.81 22 156738 22279 64319693
Choriocarcinoma 12.36 11.81 5 156755 61 64341911
Pneumoperitoneum 12.34 11.81 23 156737 2688 64339284
Pharyngitis streptococcal 12.22 11.81 3 156757 8665 64333307
Retinal infarction 12.19 11.81 7 156753 192 64341780
Arrhythmia 12.15 11.81 77 156683 52867 64289105
Osteomyelitis 12.14 11.81 31 156729 27556 64314416
Device malfunction 12.11 11.81 15 156745 17618 64324354
Venous thrombosis limb 12.11 11.81 28 156732 3809 64338163
Swelling face 12.11 11.81 89 156671 59077 64282895
Musculoskeletal discomfort 12.10 11.81 13 156747 16264 64325708
Autoimmune pancytopenia 12.09 11.81 7 156753 195 64341777
Abnormal dreams 12.09 11.81 5 156755 10351 64331621
Left ventricular hypertrophy 12.09 11.81 4 156756 9502 64332470
Secondary adrenocortical insufficiency 12.09 11.81 21 156739 2324 64339648
Myasthenia gravis 12.09 11.81 36 156724 5702 64336270
Lymphopenia 12.08 11.81 105 156655 25552 64316420
Bacterial diarrhoea 12.07 11.81 6 156754 122 64341850
Personality change 12.07 11.81 3 156757 8590 64333382
Intensive care 12 11.81 11 156749 634 64341338
Acute leukaemia 11.98 11.81 17 156743 1581 64340391
Q fever 11.97 11.81 7 156753 199 64341773
Salivary gland cancer stage IV 11.94 11.81 5 156755 67 64341905
Movement disorder 11.94 11.81 22 156738 21978 64319994
Full blood count decreased 11.88 11.81 23 156737 22559 64319413
Pelvic mass 11.85 11.81 14 156746 1086 64340886
Acute pulmonary oedema 11.85 11.81 62 156698 12747 64329225
Toxic neuropathy 11.84 11.81 12 156748 784 64341188

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01XA02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
OTHER ANTINEOPLASTIC AGENTS
Platinum compounds
FDA EXT N0000175073 Platinum-containing Compounds
FDA EPC N0000175413 Platinum-based Drug
CHEBI has role CHEBI:25435 mutagens
CHEBI has role CHEBI:35610 antineoplastic agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D003432 Cross-Linking Reagents
MeSH PA D007202 Indicators and Reagents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Breast cancer indication 254837009 DOID:1612
Malignant tumor of ovary indication 363443007 DOID:2394
Ewing's sarcoma off-label use 76909002 DOID:3369
Acute myeloid leukemia, disease off-label use 91861009
Small cell carcinoma of lung off-label use 254632001 DOID:5409
Non-small cell lung cancer off-label use 254637007 DOID:3908
Endometrial carcinoma off-label use 254878006 DOID:2871
Malignant tumor of head and/or neck off-label use 255056009
Seminoma of testis off-label use 255107005
Malignant tumor of cervix off-label use 363354003 DOID:4362
Malignant tumor of testis off-label use 363449006 DOID:2998
Malignant tumor of urinary bladder off-label use 399326009 DOID:11054
Metastatic Breast Carcinoma off-label use
Refractory Osteosarcoma off-label use
Neuroendocrine Prostate Carcinoma off-label use
Progressive Diffuse Large B-Cell Lymphoma off-label use
Acute vomiting contraindication 23971007
Acute infectious disease contraindication 63171007
Blood coagulation disorder contraindication 64779008 DOID:1247
Leukopenia contraindication 84828003 DOID:615
Kidney disease contraindication 90708001 DOID:557
Hearing disorder contraindication 128540005
Liver function tests abnormal contraindication 166603001
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Peripheral nerve disease contraindication 302226006
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Functional visual loss contraindication 313165001
Breastfeeding (mother) contraindication 413712001
Significant Bleeding contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019478 VUID
N0000147598 NUI
D01363 KEGG_DRUG
4019478 VANDF
C0079083 UMLSCUI
CHEBI:31355 CHEBI
QPT PDB_CHEM_ID
CHEMBL1351 ChEMBL_ID
CHEMBL288376 ChEMBL_ID
D016190 MESH_DESCRIPTOR_UI
DB00958 DRUGBANK_ID
7624 IUPHAR_LIGAND_ID
5231 INN_ID
BG3F62OND5 UNII
426756 PUBCHEM_CID
152200 RXNORM
3186 MMSL
37674 MMSL
4357 MMSL
d00185 MMSL
002643 NDDF
108759002 SNOMEDCT_US
386905002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
CARBOplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-4239 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 25 sections
CARBOplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-4239 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 25 sections
CARBOplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-4244 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 25 sections
CARBOplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-4244 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 25 sections
CARBOplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-4246 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 25 sections
CARBOplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-4246 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 25 sections
CARBOplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-4248 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 25 sections
CARBOplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-4248 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 25 sections
CARBOplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-4248 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 25 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 16729-295 INJECTION 10 mg INTRAVENOUS ANDA 24 sections
carboplatin Human Prescription Drug Label 1 47335-150 INJECTION 10 mg INTRAVENOUS ANDA 22 sections
carboplatin Human Prescription Drug Label 1 47335-151 INJECTION 10 mg INTRAVENOUS ANDA 22 sections
carboplatin Human Prescription Drug Label 1 47335-284 INJECTION 10 mg INTRAVENOUS ANDA 22 sections
carboplatin Human Prescription Drug Label 1 47335-300 INJECTION 10 mg INTRAVENOUS ANDA 22 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 50742-445 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 21 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 50742-446 INJECTION, SOLUTION 150 mg INTRAVENOUS ANDA 21 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 50742-447 INJECTION, SOLUTION 450 mg INTRAVENOUS ANDA 21 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 50742-448 INJECTION, SOLUTION 600 mg INTRAVENOUS ANDA 21 sections
CARBOPLATIN Human Prescription Drug Label 1 55150-333 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 23 sections
CARBOPLATIN Human Prescription Drug Label 1 55150-334 INJECTION, SOLUTION 150 mg INTRAVENOUS ANDA 23 sections
CARBOPLATIN Human Prescription Drug Label 1 55150-335 INJECTION, SOLUTION 450 mg INTRAVENOUS ANDA 23 sections
CARBOPLATIN Human Prescription Drug Label 1 55150-386 INJECTION, SOLUTION 600 mg INTRAVENOUS ANDA 23 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 57277-105 SOLUTION 50 mg INTRAVENOUS ANDA 22 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 57277-106 SOLUTION 150 mg INTRAVENOUS ANDA 22 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 57277-107 SOLUTION 450 mg INTRAVENOUS ANDA 22 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 61703-150 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 23 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 61703-262 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 23 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 61703-339 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 24 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 61703-360 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 23 sections
Carboplatin HUMAN PRESCRIPTION DRUG LABEL 1 61703-600 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 23 sections