All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

carboplatin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antineoplastic agents, platinum derivatives	4133	41575-94-4

Description:

Molecule	Description
Synonyms: paraplatin carboplatin	An organoplatinum compound that possesses antineoplastic activity. Molecular weight: 371.26 Formula: C6H12N2O4Pt CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 107.88 ALOGS: ROTB: None

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	14 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	77 %	Benet LZ, Broccatelli F, Oprea TI
Vd (Volume of distribution)	0.26 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	1.50 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	1 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	2 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
March 3, 1989	FDA
Aug. 25, 2021	PMDA	MYLAN SEIYAKU Ltd

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Neutropenia	2117.93	13.32	2211	132481	172794	63181536
Febrile neutropenia	2020.19	13.32	1808	132884	116641	63237689
Malignant neoplasm progression	1892.85	13.32	1492	133200	80629	63273701
Thrombocytopenia	1483.47	13.32	1712	132980	149445	63204885
Anaemia	1459.45	13.32	2390	132302	291040	63063290
Myelosuppression	1413.44	13.32	781	133911	22922	63331408
Disease progression	1352.18	13.32	1477	133215	121281	63233049
Neutrophil count decreased	1060.18	13.32	911	133781	55495	63298835
Pancytopenia	929.76	13.32	1086	133606	95847	63258483
Erythema	751.81	13.32	1341	133351	174410	63179920
Acute myeloid leukaemia	746.74	13.32	461	134231	16686	63337644
Neuropathy peripheral	590.03	13.32	946	133746	112721	63241609
Haematotoxicity	567.06	13.32	312	134380	9064	63345266
Joint swelling	551.23	13.32	37	134655	327629	63026701
Myelodysplastic syndrome	511.78	13.32	361	134331	16393	63337937
Neoplasm progression	507.78	13.32	498	134194	35930	63318400
Neutropenic sepsis	492.42	13.32	350	134342	16088	63338242
Pain	490.47	13.32	511	134181	740117	62614213
Flushing	478.89	13.32	688	134004	74399	63279931
Platelet count decreased	466.67	13.32	863	133829	115259	63239071
Bone marrow failure	466.38	13.32	431	134261	28859	63325471
Rheumatoid arthritis	434.66	13.32	26	134666	253793	63100537
Mucosal inflammation	425.00	13.32	511	134181	46417	63307913
Anaphylactic shock	420.05	13.32	370	134322	23263	63331067
Leukopenia	411.47	13.32	651	134041	76639	63277691
Contraindicated product administered	410.39	13.32	11	134681	217637	63136693
Vomiting	385.76	13.32	2259	132433	557358	62796972
Drug ineffective	385.60	13.32	1052	133640	1043713	62310617
Product dose omission issue	378.12	13.32	32	134660	234281	63120049
Synovitis	374.73	13.32	4	134688	186914	63167416
Arthropathy	368.32	13.32	36	134656	234756	63119574
Metastases to liver	361.20	13.32	340	134352	23299	63331031
Hypokalaemia	360.04	13.32	725	133967	103079	63251251
Nausea	354.90	13.32	3049	131643	851422	62502908
Weight increased	347.83	13.32	66	134626	260726	63093604
Therapeutic product effect decreased	345.81	13.32	15	134677	193172	63161158
Systemic lupus erythematosus	330.39	13.32	31	134661	208887	63145443
Glossodynia	330.04	13.32	11	134681	178865	63175465
Swelling	328.66	13.32	89	134603	275289	63079041
Sinusitis	327.59	13.32	46	134646	226607	63127723
White blood cell count decreased	319.29	13.32	825	133867	138279	63216051
Arthralgia	310.27	13.32	456	134236	569254	62785076
Hand deformity	308.51	13.32	6	134686	159451	63194879
Nasopharyngitis	307.52	13.32	80	134612	254177	63100153
Hypomagnesaemia	300.44	13.32	337	134355	28400	63325930
Therapy partial responder	298.75	13.32	218	134474	10440	63343890
Fall	292.69	13.32	242	134450	392092	62962238
Abdominal discomfort	291.54	13.32	159	134533	320726	63033604
Dyspnoea	284.41	13.32	2380	132312	658933	62695397
Peripheral swelling	273.49	13.32	111	134581	265831	63088499
Dehydration	271.58	13.32	897	133795	172457	63181873
Second primary malignancy	265.45	13.32	181	134511	7772	63346558
Metastases to central nervous system	265.08	13.32	221	134471	12884	63341446
Metastases to lung	264.12	13.32	218	134474	12532	63341798
Headache	257.83	13.32	605	134087	632636	62721694
Ovarian cancer recurrent	255.45	13.32	92	134600	925	63353405
Musculoskeletal stiffness	251.92	13.32	44	134648	184574	63169756
Peripheral sensory neuropathy	247.33	13.32	169	134523	7282	63347048
Metastases to bone	244.95	13.32	261	134431	20758	63333572
Maternal exposure during pregnancy	244.54	13.32	81	134611	219981	63134349
Wound	233.81	13.32	34	134658	163229	63191101
Drug intolerance	226.84	13.32	193	134499	308468	63045862
Polyneuropathy	221.25	13.32	209	134483	14380	63339950
Proteinuria	218.28	13.32	235	134457	18910	63335420
Discomfort	215.43	13.32	46	134646	167328	63187002
Colitis	210.39	13.32	373	134319	48155	63306175
Hepatic enzyme increased	210.30	13.32	83	134609	202245	63152085
Condition aggravated	194.13	13.32	348	134344	401869	62952461
Ascites	193.50	13.32	326	134366	40402	63313928
Metastases to lymph nodes	191.30	13.32	150	134542	8008	63346322
Injection site pain	190.62	13.32	25	134667	129775	63224555
Abdominal pain	181.80	13.32	1154	133538	292302	63062028
Pericarditis	180.24	13.32	31	134661	131548	63222782
Posterior reversible encephalopathy syndrome	178.87	13.32	202	134490	17143	63337187
Treatment failure	177.17	13.32	101	134591	198942	63155388
Overdose	176.81	13.32	19	134673	115059	63239271
Gastrointestinal perforation	175.58	13.32	103	134589	3388	63350942
Palmar-plantar erythrodysaesthesia syndrome	173.86	13.32	229	134463	22786	63331544
Diarrhoea	172.39	13.32	2291	132401	713075	62641255
Metastases to peritoneum	163.82	13.32	98	134594	3344	63350986
Product use issue	162.99	13.32	137	134555	220383	63133947
Blood cholesterol increased	162.74	13.32	9	134683	94023	63260307
Tumour lysis syndrome	162.21	13.32	142	134550	8848	63345482
Contusion	158.44	13.32	60	134632	149984	63204346
Pleural effusion	158.20	13.32	496	134196	92714	63261616
Sepsis	154.39	13.32	689	134003	152434	63201896
Mobility decreased	152.44	13.32	35	134657	121124	63233206
Irritable bowel syndrome	152.17	13.32	5	134687	82407	63271923
Neurotoxicity	152.08	13.32	184	134508	16806	63337524
Exposure during pregnancy	150.16	13.32	71	134621	155476	63198854
Blister	149.08	13.32	45	134647	129769	63224561
Ileus	145.93	13.32	168	134524	14557	63339773
Fibromyalgia	144.63	13.32	6	134686	80414	63273916
Duodenal ulcer perforation	143.08	13.32	11	134681	87198	63267132
Pneumonitis	142.80	13.32	263	134429	34959	63319371
Product use in unapproved indication	135.77	13.32	743	133949	178337	63175993
Influenza	135.60	13.32	32	134660	108690	63245640
Drug abuse	135.33	13.32	4	134688	72514	63281816
Pyrexia	134.60	13.32	1557	133135	468921	62885409
Migraine	133.76	13.32	28	134664	103318	63251012
Hospitalisation	133.40	13.32	13	134679	85068	63269262
Large intestine perforation	133.38	13.32	124	134568	8358	63345972
Renal salt-wasting syndrome	133.26	13.32	43	134649	299	63354031
Immune-mediated enterocolitis	132.47	13.32	72	134620	2039	63352291
Psoriasis	129.47	13.32	16	134676	86941	63267389
Epistaxis	128.95	13.32	393	134299	72332	63281998
Immune-mediated hepatic disorder	127.15	13.32	46	134646	469	63353861
Loss of personal independence in daily activities	126.66	13.32	26	134666	97264	63257066
Insomnia	126.06	13.32	163	134529	215089	63139241
Hydronephrosis	125.28	13.32	133	134559	10529	63343801
Arthritis	122.96	13.32	46	134646	115875	63238455
Injection site erythema	122.14	13.32	16	134676	83158	63271172
Depression	121.14	13.32	143	134549	196349	63157981
Type I hypersensitivity	120.22	13.32	76	134616	2866	63351464
Drug resistance	118.93	13.32	191	134501	22742	63331588
Feeling hot	116.74	13.32	300	134392	50054	63304276
Pulmonary embolism	116.03	13.32	523	134169	116161	63238169
General physical health deterioration	115.99	13.32	778	133914	200624	63153706
Pain in extremity	115.19	13.32	342	134350	331144	63023186
Skin toxicity	113.40	13.32	88	134604	4626	63349704
Tachycardia	113.32	13.32	524	134168	117632	63236698
Neutropenic colitis	111.82	13.32	74	134618	3021	63351309
Disease recurrence	110.74	13.32	207	134485	27823	63326507
Recall phenomenon	109.75	13.32	44	134648	606	63353724
Embolism	108.08	13.32	107	134585	7799	63346531
Suicide attempt	108.03	13.32	5	134687	60913	63293417
Radiation pneumonitis	107.77	13.32	57	134635	1526	63352804
Febrile bone marrow aplasia	107.37	13.32	103	134589	7222	63347108
Muscle spasms	106.98	13.32	104	134588	156046	63198284
Asthma	106.12	13.32	70	134622	127491	63226839
Metastasis	105.84	13.32	88	134604	5109	63349221
Bronchitis	103.33	13.32	69	134623	124866	63229464
Osteoarthritis	102.52	13.32	37	134655	95306	63259024
Anaphylactic reaction	102.39	13.32	341	134351	65759	63288571
Oesophagitis	100.70	13.32	141	134551	14867	63339463
Small intestinal obstruction	99.61	13.32	156	134536	18181	63336149
Palmar erythema	99.18	13.32	56	134636	1711	63352619
Injury	98.66	13.32	18	134674	73229	63281101
Acquired gene mutation	98.40	13.32	46	134646	937	63353393
Constipation	97.24	13.32	812	133880	224131	63130199
Memory impairment	96.94	13.32	50	134642	104208	63250122
Lower respiratory tract infection	95.49	13.32	84	134608	132223	63222107
Somnolence	93.03	13.32	147	134545	178538	63175792
Off label use	92.84	13.32	1973	132719	672489	62681841
Bronchospasm	92.47	13.32	146	134546	17134	63337196
Hypothyroidism	90.68	13.32	246	134446	42386	63311944
Illness	90.48	13.32	3	134689	49056	63305274
Neoplasm recurrence	90.32	13.32	61	134631	2577	63351753
Decreased appetite	88.97	13.32	868	133824	250184	63104146
Metastases to meninges	88.69	13.32	60	134632	2542	63351788
Chest discomfort	88.53	13.32	464	134228	109505	63244825
Hypertransaminasaemia	87.68	13.32	88	134604	6521	63347809
Injection site swelling	87.41	13.32	3	134689	47569	63306761
Stress	87.31	13.32	18	134674	67149	63287181
Subileus	86.77	13.32	64	134628	3115	63351215
Immune-mediated hepatitis	86.69	13.32	47	134645	1324	63353006
Injection site reaction	86.55	13.32	11	134681	58513	63295817
Cardiotoxicity	86.54	13.32	98	134594	8340	63345990
Hypocalcaemia	86.33	13.32	201	134491	31512	63322818
Drug hypersensitivity	86.04	13.32	353	134339	310334	63043996
Metastatic neoplasm	85.96	13.32	72	134620	4223	63350107
Asthenia	85.54	13.32	1213	133479	382391	62971939
Suicidal ideation	84.81	13.32	15	134677	62406	63291924
Malignant pleural effusion	83.87	13.32	58	134634	2548	63351782
Death	83.54	13.32	1184	133508	373197	62981133
Renal tubular disorder	82.36	13.32	58	134634	2624	63351706
Impaired healing	81.65	13.32	59	134633	102483	63251847
Blood pressure fluctuation	81.49	13.32	4	134688	46313	63308017
C-reactive protein abnormal	81.04	13.32	4	134688	46092	63308238
Enterocolitis infectious	80.97	13.32	48	134644	1610	63352720
Sleep disorder	79.03	13.32	37	134655	81529	63272801
EGFR gene mutation	78.87	13.32	28	134664	269	63354061
Secondary cerebellar degeneration	78.21	13.32	20	134672	50	63354280
Thrombotic microangiopathy	78.08	13.32	104	134588	10457	63343873
Haemolytic anaemia	76.85	13.32	101	134591	10024	63344306
Red blood cell sedimentation rate increased	76.74	13.32	4	134688	43978	63310352
Lymphangiosis carcinomatosa	76.29	13.32	44	134648	1401	63352929
Aplasia	76.29	13.32	67	134625	4192	63350138
Gait disturbance	75.78	13.32	173	134519	183005	63171325
Injection site bruising	75.77	13.32	3	134689	41907	63312423
Feeling abnormal	74.49	13.32	125	134567	148267	63206063
Alveolar soft part sarcoma	74.30	13.32	21	134671	86	63354244
Peripheral motor neuropathy	72.65	13.32	45	134647	1636	63352694
Folliculitis	71.11	13.32	30	134662	70287	63284043
Enterocolitis	70.15	13.32	85	134607	7773	63346557
Intentional product misuse	70.12	13.32	21	134671	60896	63293434
Nephropathy toxic	69.55	13.32	93	134599	9386	63344944
Laryngospasm	69.54	13.32	55	134637	2973	63351357
Deep vein thrombosis	68.40	13.32	355	134337	83445	63270885
Hyponatraemia	67.82	13.32	438	134254	111462	63242868
Oxygen saturation decreased	67.35	13.32	368	134324	88217	63266113
Wheezing	66.22	13.32	63	134629	95532	63258798
Drug interaction	65.50	13.32	257	134435	228874	63125456
Ototoxicity	65.39	13.32	39	134653	1323	63353007
Pregnancy	65.39	13.32	3	134689	36833	63317497
Neutropenic infection	65.26	13.32	39	134653	1328	63353002
Cataract	65.07	13.32	20	134672	57033	63297297
Gastrointestinal toxicity	64.70	13.32	81	134611	7660	63346670
Immune-mediated pancreatitis	64.35	13.32	20	134672	121	63354209
Hypotension	64.32	13.32	871	133821	271733	63082597
Disseminated intravascular coagulation	63.50	13.32	131	134561	18920	63335410
Immune-mediated dermatitis	62.64	13.32	21	134671	167	63354163
Adverse drug reaction	61.99	13.32	47	134645	79667	63274663
Sense of oppression	61.94	13.32	34	134658	982	63353348
Incorrect dose administered	61.58	13.32	25	134667	59943	63294387
Choroidal infarction	60.47	13.32	17	134675	68	63354262
Type 2 diabetes mellitus	60.31	13.32	30	134662	63838	63290492
Aortitis	59.80	13.32	34	134658	1053	63353277
Immune-mediated hypothyroidism	59.56	13.32	23	134669	285	63354045
Joint stiffness	59.24	13.32	9	134683	41860	63312470
Neutrophil count abnormal	58.95	13.32	49	134643	2843	63351487
Intestinal perforation	57.12	13.32	96	134596	11867	63342463
Abortion spontaneous	56.68	13.32	15	134677	47180	63307150
Intestinal obstruction	56.64	13.32	169	134523	30730	63323600
Inappropriate schedule of product administration	56.51	13.32	83	134609	103882	63250448
Radiation oesophagitis	56.39	13.32	23	134669	332	63353998
Myocarditis	56.30	13.32	88	134604	10237	63344093
Device related thrombosis	55.74	13.32	39	134653	1746	63352584
Throat tightness	55.33	13.32	146	134546	24741	63329589
Gastrooesophageal reflux disease	54.32	13.32	74	134618	95565	63258765
Osteoporosis	54.03	13.32	27	134665	57311	63297019
Inflammation	53.80	13.32	57	134635	82216	63272114
Anxiety	53.63	13.32	258	134434	217283	63137047
Cyanosis	53.59	13.32	114	134578	16821	63337509
Sedation	53.43	13.32	9	134683	38800	63315530
Adverse event	52.32	13.32	40	134652	67519	63286811
Recurrent cancer	51.99	13.32	39	134653	1948	63352382
Carbohydrate antigen 125 increased	51.85	13.32	45	134647	2771	63351559
Septic shock	51.45	13.32	278	134414	66351	63287979
Urogenital fistula	51.07	13.32	19	134673	211	63354119
Cardiac failure congestive	51.02	13.32	73	134619	92360	63261970
Diffuse large B-cell lymphoma recurrent	50.84	13.32	41	134651	2279	63352051
COVID-19	50.76	13.32	102	134590	113001	63241329
Gastric disorder	50.72	13.32	9	134683	37360	63316970
Joint injury	50.63	13.32	3	134689	29569	63324761
Haematuria	50.20	13.32	156	134536	29001	63325329
Hypoalbuminaemia	50.19	13.32	90	134602	11715	63342615
Product quality issue	50.09	13.32	8	134684	35857	63318473
Hepatic function abnormal	50.04	13.32	183	134509	36959	63317371
Cytopenia	50.03	13.32	89	134603	11512	63342818
Anastomotic leak	49.86	13.32	23	134669	454	63353876
Non-small cell lung cancer	49.78	13.32	49	134643	3546	63350784
Sleep apnoea syndrome	49.74	13.32	3	134689	29130	63325200
Small intestinal perforation	49.42	13.32	34	134658	1481	63352849
Acute kidney injury	49.35	13.32	809	133883	262606	63091724
Fluid retention	49.28	13.32	33	134659	59653	63294677
Hypertension	49.12	13.32	849	133843	278454	63075876
Immune-mediated lung disease	48.97	13.32	25	134667	621	63353709
Lymphocele	48.87	13.32	27	134665	790	63353540
Tumour necrosis	48.81	13.32	27	134665	792	63353538
Acute megakaryocytic leukaemia	48.63	13.32	13	134679	41	63354289
Hallucination	48.45	13.32	28	134664	54789	63299541
Anaphylactoid reaction	48.34	13.32	49	134643	3674	63350656
Nasal congestion	48.19	13.32	41	134651	65619	63288711
Bursitis	47.98	13.32	10	134682	37031	63317299
Surgery	47.98	13.32	9	134683	35903	63318427
Hepatic cytolysis	47.93	13.32	103	134589	15304	63339026
Breast cancer metastatic	47.77	13.32	89	134603	11929	63342401
Toxicity to various agents	47.55	13.32	318	134374	246932	63107398
Tumour embolism	47.53	13.32	16	134676	129	63354201
Sciatica	47.17	13.32	8	134684	34316	63320014
Immune-mediated nephritis	47	13.32	16	134676	134	63354196
Encephalopathy	46.84	13.32	184	134508	38436	63315894
Dizziness	46.71	13.32	637	134055	429288	62925042
Immune-mediated myocarditis	46.17	13.32	19	134673	281	63354049
Obesity	45.85	13.32	5	134687	29947	63324383
Nephrolithiasis	45.62	13.32	16	134676	41968	63312362
Performance status decreased	45.20	13.32	47	134645	3631	63350699
Bone pain	44.94	13.32	232	134460	54409	63299921
Hot flush	44.73	13.32	221	134471	50938	63303392
Prescribed overdose	44.70	13.32	9	134683	34144	63320186
Ill-defined disorder	44.69	13.32	65	134627	81690	63272640
Rash maculo-papular	44.53	13.32	159	134533	31737	63322593
Hypoxia	44.50	13.32	247	134445	59545	63294785
Skin candida	44.45	13.32	33	134659	1622	63352708
Metastases to skin	44.31	13.32	33	134659	1630	63352700
Amnesia	44.21	13.32	32	134660	55553	63298777
Pneumothorax	44.18	13.32	103	134589	16158	63338172
Paraesthesia	44.00	13.32	518	134174	156448	63197882
Confusional state	43.97	13.32	307	134385	236073	63118257
Plasma cell myeloma	43.90	13.32	11	134681	35894	63318436
Ovarian cancer metastatic	43.89	13.32	26	134666	871	63353459
Joint range of motion decreased	43.60	13.32	8	134684	32420	63321910
Endocarditis noninfective	43.09	13.32	12	134680	46	63354284
Left ventricular dysfunction	43.01	13.32	85	134607	11903	63342427
Unevaluable event	42.98	13.32	28	134664	51358	63302972
Hepatotoxicity	42.93	13.32	174	134518	36867	63317463
Prescribed underdose	42.89	13.32	6	134686	29683	63324647
Metastases to spine	42.62	13.32	43	134649	3206	63351124
Hyperthyroidism	42.14	13.32	95	134597	14578	63339752
Urinary tract obstruction	42.10	13.32	36	134656	2172	63352158
Basal cell carcinoma	42.02	13.32	5	134687	27986	63326344
Ejection fraction decreased	41.75	13.32	123	134569	22209	63332121
Therapy interrupted	41.55	13.32	9	134683	32446	63321884
Road traffic accident	41.49	13.32	13	134679	36619	63317711
Metastases to abdominal wall	41.47	13.32	14	134678	114	63354216
Gait inability	41.46	13.32	31	134661	52928	63301402
Cerebral infarction	41.28	13.32	128	134564	23765	63330565
Hypersensitivity	41.26	13.32	860	133832	291825	63062505
Acute promyelocytic leukaemia	40.53	13.32	25	134667	902	63353428
Femur fracture	40.35	13.32	19	134673	41737	63312593
PIK3CA-activated mutation	39.91	13.32	26	134666	1033	63353297
Acute erythroid leukaemia	39.88	13.32	12	134680	64	63354266
Respiratory distress	39.76	13.32	160	134532	33791	63320539
Diabetes mellitus	39.57	13.32	36	134656	55774	63298556
Gastrointestinal disorder	39.55	13.32	144	134548	131095	63223235
Alopecia areata	39.54	13.32	31	134661	1654	63352676
Ovarian epithelial cancer recurrent	39.26	13.32	9	134683	11	63354319
Heart rate decreased	39.24	13.32	24	134668	45536	63308794
Cervix carcinoma recurrent	39.21	13.32	14	134678	137	63354193
Hyperhidrosis	39.18	13.32	375	134317	107461	63246869
Hypopituitarism	38.00	13.32	26	134666	1122	63353208
Ovarian disorder	37.93	13.32	22	134670	708	63353622
Infusion related hypersensitivity reaction	37.91	13.32	16	134676	253	63354077
Pericardial effusion	37.91	13.32	145	134547	29913	63324417
Hypophosphataemia	37.41	13.32	78	134614	11348	63342982
Tumour associated fever	37.35	13.32	17	134675	325	63354005
Pelvic abscess	37.19	13.32	30	134662	1668	63352662
Nervousness	36.91	13.32	10	134682	30969	63323361
Infected lymphocele	36.87	13.32	15	134677	215	63354115
Medication error	36.74	13.32	34	134658	52250	63302080
Alopecia	36.66	13.32	500	134192	337036	63017294
Serotonin syndrome	36.63	13.32	8	134684	28674	63325656
Underdose	36.43	13.32	7	134685	27449	63326881
Thrombophlebitis migrans	36.24	13.32	13	134679	129	63354201
Terminal agitation	36.10	13.32	7	134685	0	63354330
Immune-mediated hyperthyroidism	35.95	13.32	12	134680	94	63354236
Venous thrombosis	35.82	13.32	48	134644	4854	63349476
Agranulocytosis	35.69	13.32	126	134566	25008	63329322
Abdominal abscess	35.67	13.32	46	134646	4480	63349850
Blood pressure systolic increased	35.51	13.32	29	134663	47368	63306962
Madarosis	35.43	13.32	38	134654	3043	63351287
Live birth	35.16	13.32	6	134686	25624	63328706
Muscle spasticity	35.04	13.32	3	134689	21791	63332539
Mechanical ileus	34.96	13.32	19	134673	538	63353792
Colitis ischaemic	34.94	13.32	73	134619	10635	63343695
Thyroiditis	34.87	13.32	34	134658	2432	63351898
Inappropriate antidiuretic hormone secretion	34.67	13.32	91	134601	15371	63338959
Pain in jaw	34.65	13.32	25	134667	43471	63310859
Treatment noncompliance	34.53	13.32	18	134674	37307	63317023
Respiratory failure	34.46	13.32	349	134343	101509	63252821
VIth nerve paralysis	34.37	13.32	22	134670	848	63353482
Upper respiratory tract infection	34.30	13.32	77	134615	81970	63272360
Foot fracture	34.16	13.32	5	134687	23909	63330421
Dysphagia	34.15	13.32	312	134380	88273	63266057
Cholangitis	34.01	13.32	50	134642	5511	63348819
Papilloedema	34.00	13.32	42	134650	3918	63350412
Lichenoid keratosis	33.85	13.32	29	134663	1754	63352576
Shock	33.64	13.32	118	134574	23345	63330985
Dermatitis acneiform	33.61	13.32	47	134645	4949	63349381
Endometrial cancer recurrent	33.57	13.32	8	134684	13	63354317
Hip arthroplasty	33.46	13.32	31	134661	47615	63306715
Leukoencephalopathy	33.46	13.32	44	134648	4369	63349961
Hypophysitis	33.05	13.32	29	134663	1812	63352518
BRCA2 gene mutation	32.86	13.32	11	134681	87	63354243
Rhabdomyolysis	32.80	13.32	27	134665	43924	63310406
Hepatitis	32.76	13.32	169	134523	39619	63314711
Metastases to breast	32.66	13.32	15	134677	293	63354037
Radiation myelopathy	32.63	13.32	9	134683	33	63354297
Metastases to pleura	32.61	13.32	27	134665	1558	63352772
Haemoptysis	32.54	13.32	134	134558	28592	63325738
Dermatomyositis	32.53	13.32	35	134657	2813	63351517
Hypervolaemia	32.32	13.32	10	134682	28403	63325927
Extravasation	32.23	13.32	32	134660	2340	63351990
Myeloid leukaemia	32.07	13.32	16	134676	378	63353952
Procedural pain	32.02	13.32	4	134688	21565	63332765
Interstitial lung disease	31.95	13.32	233	134459	61675	63292655
Haemoglobin decreased	31.89	13.32	459	134233	145026	63209304
Blast cells present	31.88	13.32	17	134675	463	63353867
Venoocclusive liver disease	31.80	13.32	45	134647	4790	63349540
Drug reaction with eosinophilia and systemic symptoms	31.78	13.32	16	134676	33820	63320510
Mental disorder	31.57	13.32	8	134684	25911	63328419
Stress cardiomyopathy	31.51	13.32	65	134627	9385	63344945
Hypertensive crisis	31.30	13.32	87	134605	15199	63339131
Obstructive shock	31.25	13.32	9	134683	40	63354290
Immune-mediated gastritis	31.25	13.32	9	134683	40	63354290
Gastric perforation	31.25	13.32	27	134665	1652	63352678
Myositis	31.21	13.32	64	134628	9202	63345128
Immune-mediated adrenal insuficiency	31.18	13.32	10	134682	68	63354262
Tubulointerstitial nephritis	31.09	13.32	103	134589	19800	63334530
Autoimmune nephritis	31.03	13.32	16	134676	406	63353924
Herpes zoster	30.84	13.32	82	134610	82380	63271950
Paraneoplastic neurological syndrome	30.79	13.32	7	134685	8	63354322
Macular degeneration	30.72	13.32	7	134685	24369	63329961
Carpal tunnel syndrome	30.56	13.32	4	134688	20813	63333517
Head injury	30.53	13.32	10	134682	27386	63326944
Product prescribing error	30.36	13.32	9	134683	26280	63328050
Localised infection	30.36	13.32	13	134679	30197	63324133
Peripheral ischaemia	30.04	13.32	44	134648	4834	63349496
Administration site extravasation	29.94	13.32	21	134671	944	63353386
Nightmare	29.90	13.32	3	134689	19191	63335139
Vaginal fistula	29.86	13.32	16	134676	440	63353890
Hair colour changes	29.85	13.32	35	134657	3092	63351238
Fatigue	29.81	13.32	1561	133131	886467	62467863
Embolism arterial	29.76	13.32	21	134671	953	63353377
Irritability	29.75	13.32	15	134677	31679	63322651
Small cell lung cancer	29.65	13.32	26	134666	1623	63352707
Eye disorder	29.64	13.32	6	134686	22679	63331651
Acute monocytic leukaemia	29.42	13.32	11	134681	124	63354206
Influenza like illness	29.35	13.32	61	134631	66763	63287567
Psychotic disorder	29.34	13.32	9	134683	25703	63328627
Cancer pain	29.15	13.32	35	134657	3170	63351160
Injection site rash	29.15	13.32	3	134689	18806	63335524
Sinus disorder	29.11	13.32	8	134684	24545	63329785
Eye pain	28.92	13.32	18	134674	33836	63320494
Febrile infection	28.91	13.32	25	134667	1532	63352798
Mixed deafness	28.78	13.32	7	134685	13	63354317
Malignant ascites	28.77	13.32	20	134672	886	63353444
Hyperpyrexia	28.76	13.32	37	134655	3595	63350735
Bronchial fistula	28.66	13.32	8	134684	31	63354299
Peritoneal disorder	28.42	13.32	16	134676	486	63353844
Malignant transformation	28.34	13.32	15	134677	402	63353928
Pseudocirrhosis	28.23	13.32	18	134674	689	63353641
Immune-mediated thyroiditis	28.22	13.32	11	134681	140	63354190
Cold sweat	28.14	13.32	72	134620	11975	63342355
Gastrointestinal necrosis	27.85	13.32	32	134660	2766	63351564
Onycholysis	27.84	13.32	25	134667	1611	63352719
Pneumonia	27.82	13.32	747	133945	456020	62898310
Blood creatinine increased	27.82	13.32	297	134395	87547	63266783
Rectal perforation	27.43	13.32	15	134677	430	63353900
Metastases to bladder	27.33	13.32	12	134680	210	63354120
Incorrect route of product administration	27.29	13.32	12	134680	27440	63326890
Myocardial infarction	27.28	13.32	114	134578	99779	63254551
Bicytopenia	27.24	13.32	30	134662	2475	63351855
Nephritis	27.13	13.32	30	134662	2486	63351844
Upper limb fracture	27.01	13.32	4	134688	18964	63335366
Bone erosion	27.01	13.32	3	134689	17714	63336616
Panic attack	27.00	13.32	7	134685	22324	63332006
Metastases to adrenals	26.93	13.32	18	134674	747	63353583
Full blood count abnormal	26.91	13.32	17	134675	31700	63322630
Pelvic infection	26.88	13.32	14	134678	363	63353967
Double hit lymphoma	26.80	13.32	6	134686	6	63354324
Sopor	26.69	13.32	7	134685	22157	63332173
Tracheal fistula	26.69	13.32	8	134684	42	63354288
Joint dislocation	26.69	13.32	4	134688	18796	63335534
Metastases to pelvis	26.63	13.32	15	134677	456	63353874
Breast cancer recurrent	26.50	13.32	39	134653	4302	63350028
Oligoastrocytoma	26.45	13.32	7	134685	21	63354309
Seasonal allergy	26.44	13.32	6	134686	20944	63333386
Urosepsis	26.42	13.32	93	134599	18431	63335899
Autoimmune haemolytic anaemia	26.18	13.32	40	134652	4561	63349769
Haemoglobin	26.12	13.32	11	134681	173	63354157
Lymphadenopathy mediastinal	26.09	13.32	31	134661	2777	63351553
Musculoskeletal pain	26.01	13.32	104	134588	92173	63262157
Ovarian cancer	25.97	13.32	46	134646	5930	63348400
Rash pruritic	25.92	13.32	55	134637	59744	63294586
Bradycardia	25.76	13.32	75	134617	73152	63281178
Tumour marker increased	25.57	13.32	41	134651	4874	63349456
Serous cystadenocarcinoma ovary	25.52	13.32	7	134685	25	63354305
Electrolyte imbalance	25.44	13.32	97	134595	19979	63334351
Hypersomnia	25.27	13.32	4	134688	18051	63336279
Peritonitis	25.23	13.32	87	134605	17067	63337263
Liver injury	25.13	13.32	57	134635	60463	63293867
Jugular vein thrombosis	25.06	13.32	32	134660	3086	63351244
Eastern Cooperative Oncology Group performance status worsened	25.05	13.32	21	134671	1233	63353097
Hyperbilirubinaemia	24.77	13.32	66	134626	11248	63343082
Dyskinesia	24.71	13.32	19	134673	31983	63322347
Scintillating scotoma	24.42	13.32	10	134682	146	63354184
Device dislocation	24.37	13.32	12	134680	25693	63328637
Metastases to kidney	24.27	13.32	11	134681	208	63354122
Tumour hyperprogression	24.19	13.32	9	134683	100	63354230
Tumour pseudoprogression	24.19	13.32	12	134680	280	63354050
Dysaesthesia	24.18	13.32	38	134654	4440	63349890
Device related infection	24.08	13.32	106	134586	23286	63331044
Breast cancer	24.03	13.32	41	134651	48342	63305988
Tumour haemorrhage	24.03	13.32	23	134669	1608	63352722
Tendonitis	24.00	13.32	6	134686	19609	63334721
Tremor	23.95	13.32	173	134519	132066	63222264
Gastrointestinal fistula	23.79	13.32	14	134678	463	63353867
Nail disorder	23.68	13.32	71	134621	12944	63341386
Lymphadenopathy	23.56	13.32	151	134541	38307	63316023
Emphysematous cystitis	23.53	13.32	10	134682	161	63354169
Metastases to chest wall	23.44	13.32	15	134677	578	63353752
Intentional product use issue	23.32	13.32	167	134525	127725	63226605
Oropharyngeal pain	23.29	13.32	112	134580	94375	63259955
Cerebral ischaemia	23.29	13.32	47	134645	6681	63347649
Kidney infection	23.25	13.32	10	134682	23166	63331164
Embolism venous	23.22	13.32	31	134661	3123	63351207
Paronychia	23.11	13.32	42	134650	5523	63348807
Dysstasia	23.11	13.32	8	134684	21158	63333172
Emotional distress	23.06	13.32	21	134671	32528	63321802
Hypoglycaemia	23.02	13.32	59	134633	60006	63294324
Unmasking of previously unidentified disease	23.00	13.32	18	134674	958	63353372
BRCA1 gene mutation	22.92	13.32	6	134686	17	63354313
Ankle fracture	22.76	13.32	5	134687	17850	63336480
Arterioenteric fistula	22.67	13.32	6	134686	18	63354312
Bacterial tracheitis	22.67	13.32	6	134686	18	63354312
Visual impairment	22.67	13.32	97	134595	84349	63269981
Duodenal perforation	22.65	13.32	17	134675	850	63353480
TP53 gene mutation	22.57	13.32	7	134685	42	63354288
Gastroenteritis viral	22.57	13.32	11	134681	23689	63330641
Dyspnoea at rest	22.56	13.32	35	134657	4044	63350286
Fungal infection	22.52	13.32	27	134665	36847	63317483
Skin laceration	22.46	13.32	10	134682	22698	63331632
Metastases to spinal cord	22.45	13.32	9	134683	124	63354206
Acute myelomonocytic leukaemia	22.37	13.32	10	134682	183	63354147
Retinal pigment epitheliopathy	22.35	13.32	11	134681	252	63354078
Autoimmune dermatitis	22.32	13.32	9	134683	126	63354204
Oesophagobronchial fistula	22.30	13.32	7	134685	44	63354286
Rib fracture	22.27	13.32	10	134682	22587	63331743
Failure to thrive	22.25	13.32	48	134644	7150	63347180
Haemolytic uraemic syndrome	22.22	13.32	27	134665	2476	63351854
Hormone receptor positive breast cancer	22.10	13.32	14	134678	530	63353800
Periarticular thenar erythema with onycholysis	22.03	13.32	7	134685	46	63354284
Gastropleural fistula	21.90	13.32	7	134685	47	63354283
Viral infection	21.90	13.32	26	134666	35637	63318693
Face oedema	21.89	13.32	93	134599	20119	63334211
Optic glioma	21.86	13.32	5	134687	6	63354324
Ileal perforation	21.80	13.32	13	134679	441	63353889
Dry mouth	21.79	13.32	88	134604	77775	63276555
Weight decreased	21.79	13.32	435	134257	276363	63077967
Vena cava thrombosis	21.75	13.32	25	134667	2162	63352168
Product storage error	21.66	13.32	3	134689	14953	63339377
Coronary artery disease	21.65	13.32	22	134670	32355	63321975
Capillary leak syndrome	21.63	13.32	25	134667	2175	63352155
Urticaria	21.62	13.32	236	134456	165566	63188764
Neck pain	21.58	13.32	75	134617	69243	63285087
Acoustic stimulation tests abnormal	21.57	13.32	8	134684	88	63354242
Splenic artery thrombosis	21.53	13.32	7	134685	50	63354280
Tachypnoea	21.43	13.32	83	134609	17219	63337111
Product substitution issue	21.39	13.32	4	134688	15992	63338338
Radiation skin injury	21.38	13.32	17	134675	926	63353404
Joint effusion	21.30	13.32	5	134687	17055	63337275
Device issue	21.22	13.32	12	134680	23769	63330561
Granulocyte count decreased	21.20	13.32	19	134673	1221	63353109
Superior vena cava syndrome	21.19	13.32	15	134677	684	63353646
Type 1 lepra reaction	21.03	13.32	5	134687	8	63354322
Autoimmune myocarditis	21.02	13.32	8	134684	95	63354235
Drug level increased	20.98	13.32	11	134681	22725	63331605
Guillain-Barre syndrome	20.97	13.32	33	134659	3860	63350470
Oral herpes	20.75	13.32	15	134677	26059	63328271
Heavy menstrual bleeding	20.68	13.32	6	134686	17767	63336563
No adverse event	20.65	13.32	35	134657	41370	63312960
Heat cramps	20.63	13.32	4	134688	0	63354330
Glomerular vascular disorder	20.63	13.32	7	134685	58	63354272
Haemoglobinaemia	20.52	13.32	7	134685	59	63354271
Acute lymphocytic leukaemia	20.51	13.32	26	134666	2490	63351840
Neoplasm	20.47	13.32	47	134645	7298	63347032
Product administration error	20.43	13.32	11	134681	22386	63331944
Bladder perforation	20.42	13.32	9	134683	159	63354171
Microangiopathic haemolytic anaemia	20.36	13.32	14	134678	609	63353721
Wound dehiscence	20.36	13.32	37	134655	4866	63349464
Hyperlipidaemia	20.35	13.32	8	134684	19563	63334767
Lipoprotein increased	20.32	13.32	5	134687	10	63354320
Night sweats	20.24	13.32	46	134646	48768	63305562
Pruritus	20.23	13.32	949	133743	360504	62993826
Blood glucose increased	20.23	13.32	100	134592	83656	63270674
Cholangitis sclerosing	20.22	13.32	21	134671	1620	63352710
Platelet count abnormal	20.22	13.32	30	134662	3334	63350996
Hair texture abnormal	20.19	13.32	34	134658	4209	63350121
Faecaloma	20.17	13.32	49	134643	7892	63346438
Laryngeal discomfort	20.16	13.32	11	134681	314	63354016
Tooth disorder	20.15	13.32	18	134674	28139	63326191
Impaired work ability	20.15	13.32	6	134686	17469	63336861
Spinal cord paralysis	20.10	13.32	6	134686	31	63354299
Therapy cessation	20.02	13.32	21	134671	30436	63323894
Chills	20.01	13.32	345	134347	113033	63241297
Radiation mucositis	19.94	13.32	6	134686	32	63354298
Skin reaction	19.86	13.32	73	134619	14776	63339554
Enteritis	19.85	13.32	50	134642	8236	63346094
Limb injury	19.83	13.32	15	134677	25462	63328868
Wrong technique in product usage process	19.71	13.32	67	134625	62273	63292057
BRAF V600E mutation positive	19.64	13.32	6	134686	34	63354296
Myasthenic syndrome	19.53	13.32	10	134682	250	63354080
Dystonia	19.48	13.32	3	134689	13816	63340514
Laryngeal cancer stage III	19.41	13.32	5	134687	13	63354317
Spinal cord infarction	19.38	13.32	10	134682	254	63354076
Immune-mediated cholangitis	19.35	13.32	6	134686	36	63354294
Circulatory collapse	19.34	13.32	95	134597	21843	63332487
Lymphocyte count decreased	19.28	13.32	120	134572	30137	63324193
Therapeutic product effect incomplete	19.23	13.32	171	134521	124885	63229445
Syncope	19.23	13.32	353	134339	117032	63237298
Glaucoma	19.21	13.32	8	134684	18897	63335433
Ureteric fistula	19.14	13.32	5	134687	14	63354316
Angiodermatitis	19.12	13.32	7	134685	74	63354256
Accidental overdose	19.09	13.32	13	134679	23296	63331034
Wrist fracture	19.04	13.32	3	134689	13584	63340746
Renal tubular necrosis	19.02	13.32	62	134630	11816	63342514
Urinary tract infection enterococcal	18.96	13.32	26	134666	2687	63351643
Onychalgia	18.86	13.32	16	134676	955	63353375
Respiratory fatigue	18.76	13.32	8	134684	130	63354200
Head discomfort	18.71	13.32	3	134689	13412	63340918
Liver function test abnormal	18.71	13.32	47	134645	48134	63306196
Feeling jittery	18.69	13.32	3	134689	13400	63340930
Bronchostenosis	18.67	13.32	12	134680	466	63353864
Vaginal perforation	18.65	13.32	5	134687	16	63354314
Retinoblastoma	18.63	13.32	7	134685	80	63354250
Sinus tachycardia	18.55	13.32	101	134591	24167	63330163
Jaw operation	18.55	13.32	15	134677	837	63353493
Cholelithiasis	18.54	13.32	41	134651	43884	63310446
Female genital tract fistula	18.51	13.32	46	134646	7513	63346817
Lactic acidosis	18.51	13.32	33	134659	38254	63316076
Ear pain	18.50	13.32	30	134662	36088	63318242
Extrapyramidal disorder	18.46	13.32	3	134689	13281	63341049
Metastases to the mediastinum	18.44	13.32	12	134680	476	63353854
Ulcer	18.31	13.32	17	134675	26090	63328240
Hallucination, visual	18.31	13.32	9	134683	19289	63335041
Metastases to pancreas	18.31	13.32	10	134682	286	63354044
Neutrophil count	18.28	13.32	10	134682	287	63354043
Hypovolaemia	18.27	13.32	57	134635	10616	63343714
Gene mutation	18.21	13.32	20	134672	1645	63352685
Ischaemic stroke	18.21	13.32	81	134611	17876	63336454
Lupus-like syndrome	18.10	13.32	5	134687	15290	63339040
Balance disorder	18.05	13.32	105	134587	84317	63270013
Paraneoplastic syndrome	18.04	13.32	13	134679	610	63353720
Meningitis herpes	18.02	13.32	9	134683	213	63354117
Intestinal strangulation	17.96	13.32	7	134685	89	63354241
Pulse absent	17.96	13.32	37	134655	5337	63348993
Pulmonary vascular disorder	17.96	13.32	11	134681	392	63353938
Iron deficiency anaemia	17.93	13.32	10	134682	19959	63334371
Pulmonary haemorrhage	17.91	13.32	44	134648	7137	63347193
Sinus congestion	17.89	13.32	8	134684	18115	63336215
Systemic infection	17.89	13.32	34	134658	4626	63349704
Plantar erythema	17.87	13.32	9	134683	217	63354113
Crying	17.84	13.32	14	134678	23329	63331001
Acne	17.76	13.32	14	134678	23279	63331051
Hepatic failure	17.71	13.32	133	134559	35523	63318807
Hallucination, auditory	17.59	13.32	3	134689	12821	63341509
Blood pressure increased	17.58	13.32	240	134452	161822	63192508
Dermatitis	17.58	13.32	77	134615	16881	63337449
Immune-mediated encephalitis	17.58	13.32	9	134683	225	63354105
Intestinal metastasis	17.57	13.32	8	134684	153	63354177
Laryngitis	17.54	13.32	7	134685	16960	63337370
Spinal stenosis	17.44	13.32	5	134687	14920	63339410
Therapeutic response unexpected	17.42	13.32	9	134683	18750	63335580
Cerebrovascular accident	17.37	13.32	146	134546	107878	63246452
Hypercholesterolaemia	17.33	13.32	12	134680	21322	63333008
Aorto-oesophageal fistula	17.22	13.32	5	134687	23	63354307
Tumour fistulisation	17.22	13.32	5	134687	23	63354307
Aplastic anaemia	17.22	13.32	52	134640	9517	63344813
Myelitis transverse	17.12	13.32	17	134675	1243	63353087
Hernia	17.12	13.32	3	134689	12571	63341759
Blood triglycerides increased	16.96	13.32	3	134689	12485	63341845
Bone marrow infiltration	16.96	13.32	13	134679	671	63353659
Gamma-glutamyltransferase increased	16.94	13.32	127	134565	33904	63320426
Brachydactyly	16.92	13.32	7	134685	105	63354225
Refractory anaemia with an excess of blasts	16.91	13.32	11	134681	436	63353894
Venous thrombosis limb	16.91	13.32	26	134666	2982	63351348
Bone density decreased	16.88	13.32	5	134687	14607	63339723
Swollen tongue	16.82	13.32	30	134662	34770	63319560
Adrenal insufficiency	16.82	13.32	79	134613	17836	63336494
Cardiac murmur	16.77	13.32	5	134687	14547	63339783
Acute leukaemia	16.72	13.32	16	134676	1118	63353212
Oesophageal stenosis	16.65	13.32	27	134665	3239	63351091
Sideroblastic anaemia	16.60	13.32	4	134688	7	63354323
Aortic dissection rupture	16.60	13.32	4	134688	7	63354323
Hip fracture	16.53	13.32	23	134669	29451	63324879
Cardiac disorder	16.48	13.32	54	134638	50762	63303568
Poor quality sleep	16.48	13.32	11	134681	19924	63334406
Laryngeal oedema	16.40	13.32	37	134655	5681	63348649
Barotrauma	16.39	13.32	8	134684	180	63354150
Obstructive airways disorder	16.35	13.32	12	134680	20687	63333643
Retinal infarction	16.34	13.32	6	134686	64	63354266
Musculoskeletal disorder	16.26	13.32	12	134680	20632	63333698
Application site recall reaction	16.25	13.32	4	134688	8	63354322
Pseudomembranous colitis	16.24	13.32	26	134666	3086	63351244
Lymphangioleiomyomatosis	16.23	13.32	8	134684	184	63354146
Retroperitoneal abscess	16.23	13.32	8	134684	184	63354146
Abnormal behaviour	16.19	13.32	13	134679	21413	63332917
Bronchiectasis	16.14	13.32	7	134685	16135	63338195
Pyomyositis	16.11	13.32	10	134682	365	63353965
Neonatal respiratory depression	16.10	13.32	6	134686	67	63354263
Lymphoedema	16.08	13.32	58	134634	11634	63342696
Thrombotic thrombocytopenic purpura	15.99	13.32	29	134663	3807	63350523
Hydrocephalus	15.99	13.32	35	134657	5265	63349065
Thrombocytosis	15.97	13.32	37	134655	5781	63348549
Intestinal ischaemia	15.78	13.32	43	134649	7425	63346905
Clostridium bacteraemia	15.70	13.32	8	134684	198	63354132
Immunodeficiency	15.67	13.32	12	134680	20242	63334088
Hepatic cancer metastatic	15.66	13.32	10	134682	384	63353946
Autoimmune hypothyroidism	15.62	13.32	8	134684	200	63354130
Dyspepsia	15.60	13.32	140	134552	102056	63252274
Eczema asteatotic	15.59	13.32	9	134683	287	63354043
Chronic sinusitis	15.57	13.32	4	134688	12839	63341491
Radiotherapy	15.54	13.32	10	134682	389	63353941
Polymicrogyria	15.49	13.32	6	134686	75	63354255
Osteosarcoma	15.47	13.32	7	134685	132	63354198
Eczema	15.46	13.32	28	134664	32263	63322067
Coma	15.45	13.32	77	134615	64287	63290043
Coating in mouth	15.44	13.32	8	134684	205	63354125
Infusion site thrombosis	15.37	13.32	7	134685	134	63354196
Vaginal cuff dehiscence	15.37	13.32	4	134688	11	63354319
Immune-mediated arthritis	15.35	13.32	6	134686	77	63354253
Toxic skin eruption	15.30	13.32	61	134631	12824	63341506
Blood potassium increased	15.28	13.32	10	134682	18299	63336031
Cachexia	15.26	13.32	36	134656	5690	63348640
Agitation	15.21	13.32	70	134622	59687	63294643
Mood swings	15.18	13.32	10	134682	18238	63336092
Ocular vascular disorder	15.18	13.32	10	134682	405	63353925
Blood culture positive	15.12	13.32	32	134660	4703	63349627
Glioblastoma multiforme	15.12	13.32	13	134679	790	63353540
Adenosquamous cell lung cancer stage IV	15.11	13.32	4	134688	12	63354318
Chronic kidney disease	15.08	13.32	155	134537	45243	63309087
Iris atrophy	15.07	13.32	6	134686	81	63354249
Immune thrombocytopenia	15.06	13.32	53	134639	10503	63343827
Ovarian epithelial cancer	14.99	13.32	9	134683	309	63354021
Nervous system disorder	14.96	13.32	79	134613	18687	63335643
Intestinal prolapse	14.96	13.32	7	134685	143	63354187
Glioma	14.94	13.32	9	134683	311	63354019
Dry eye	14.89	13.32	41	134651	40720	63313610
Right ventricular failure	14.88	13.32	9	134683	17179	63337151
Skin oedema	14.87	13.32	14	134678	959	63353371
Autoimmune disorder	14.86	13.32	9	134683	17168	63337162
Cytokine release syndrome	14.84	13.32	65	134627	14249	63340081
Bacterial diarrhoea	14.81	13.32	6	134686	85	63354245
Systemic scleroderma	14.77	13.32	14	134678	967	63353363
Ocular hyperaemia	14.73	13.32	19	134673	25125	63329205
Dementia	14.71	13.32	11	134681	18783	63335547
Hypermagnesaemia	14.71	13.32	14	134678	972	63353358
Eye excision	14.67	13.32	5	134687	42	63354288
Haemoglobin abnormal	14.67	13.32	33	134659	5055	63349275
Pelvic fracture	14.65	13.32	5	134687	13343	63340987
Fracture	14.65	13.32	12	134680	19572	63334758
Autoimmune cholangitis	14.64	13.32	4	134688	14	63354316
Eye irritation	14.61	13.32	15	134677	21956	63332374
Aortic embolus	14.57	13.32	5	134687	43	63354287
Subclavian vein thrombosis	14.57	13.32	19	134673	1871	63352459
Respiratory tract congestion	14.53	13.32	10	134682	17822	63336508
Gout	14.52	13.32	5	134687	13266	63341064
Non-small cell lung cancer recurrent	14.50	13.32	6	134686	90	63354240
Metastases to retroperitoneum	14.36	13.32	7	134685	157	63354173
Blood corticotrophin decreased	14.32	13.32	9	134683	336	63353994
Facet joint syndrome	14.30	13.32	4	134688	12134	63342196
Ovarian cyst	14.30	13.32	8	134684	15937	63338393
Blood glucose decreased	14.28	13.32	14	134678	20938	63333392
Uterine adhesions	14.28	13.32	5	134687	46	63354284
Pharyngitis	14.27	13.32	13	134679	20130	63334200
Anal sphincter atony	14.24	13.32	8	134684	242	63354088
Clonal haematopoiesis	14.23	13.32	4	134688	16	63354314
Hepatic cirrhosis	14.18	13.32	19	134673	24715	63329615
Dermatitis bullous	14.16	13.32	45	134647	8463	63345867
Abdominal compartment syndrome	14.11	13.32	11	134681	582	63353748
Hypophagia	14.09	13.32	114	134578	31145	63323185
Hepatitis toxic	14.08	13.32	25	134667	3228	63351102
Lung cancer metastatic	14.08	13.32	22	134670	2558	63351772
Vesical fistula	14.04	13.32	6	134686	98	63354232
Chromosomal mutation	14.03	13.32	4	134688	17	63354313
Metastases to vagina	14.03	13.32	4	134688	17	63354313
Abdominal infection	13.97	13.32	19	134673	1949	63352381
International normalised ratio increased	13.93	13.32	51	134641	46374	63307956
Transaminases increased	13.92	13.32	114	134578	31253	63323077
Osteomyelitis	13.91	13.32	21	134671	25999	63328331
Transformation to acute myeloid leukaemia	13.86	13.32	8	134684	255	63354075
Pneumoretroperitoneum	13.85	13.32	4	134688	18	63354312
Type II hypersensitivity	13.85	13.32	4	134688	18	63354312
Electrocardiogram QT prolonged	13.84	13.32	72	134620	59458	63294872
Diffuse large B-cell lymphoma refractory	13.84	13.32	15	134677	1215	63353115
Peripheral paralysis	13.77	13.32	6	134686	103	63354227
Ligament sprain	13.70	13.32	5	134687	12795	63341535
Post procedural fistula	13.69	13.32	8	134684	261	63354069
Epiphyses premature fusion	13.65	13.32	5	134687	53	63354277
Respiratory depression	13.63	13.32	6	134686	13709	63340621
Poisoning	13.60	13.32	6	134686	13694	63340636
Pharyngitis streptococcal	13.58	13.32	3	134689	10669	63343661
Areflexia	13.55	13.32	24	134668	3094	63351236
Protein urine	13.54	13.32	12	134680	760	63353570
Thinking abnormal	13.53	13.32	3	134689	10640	63343690
Positron emission tomogram abnormal	13.42	13.32	8	134684	271	63354059
Kernicterus	13.40	13.32	3	134689	3	63354327
Acquired tracheo-oesophageal fistula	13.40	13.32	3	134689	3	63354327
Pulmonary radiation injury	13.40	13.32	3	134689	3	63354327
Ventriculo-peritoneal shunt	13.40	13.32	3	134689	3	63354327
Ovarian epithelial cancer metastatic	13.40	13.32	3	134689	3	63354327
Peritoneal neoplasm	13.40	13.32	5	134687	56	63354274
Optic atrophy	13.37	13.32	15	134677	1263	63353067
Ovarian cancer stage IV	13.37	13.32	8	134684	273	63354057

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Malignant neoplasm progression	1422.24	13.15	1426	89247	86620	34779638
Febrile neutropenia	1237.15	13.15	1642	89031	135207	34731051
Disease progression	965.07	13.15	1290	89383	106787	34759471
Neutropenia	904.32	13.15	1525	89148	155253	34711005
Thrombocytopenia	750.04	13.15	1403	89270	154844	34711414
Pancytopenia	732.35	13.15	1058	89615	94099	34772159
Myelosuppression	501.52	13.15	409	90264	18856	34847402
Anaemia	497.06	13.15	1528	89145	231807	34634451
Neutrophil count decreased	479.67	13.15	626	90047	50478	34815780
Mucosal inflammation	474.32	13.15	542	90131	38080	34828178
Interstitial lung disease	444.54	13.15	686	89987	64596	34801662
Therapy partial responder	393.61	13.15	268	90405	9348	34856910
Leukopenia	383.13	13.15	628	90045	62228	34804030
Bone marrow failure	366.66	13.15	415	90258	28838	34837420
Radiation pneumonitis	310.73	13.15	147	90526	2493	34863765
Haematotoxicity	303.99	13.15	215	90458	7979	34858279
Neoplasm progression	275.83	13.15	321	90352	22979	34843279
Neutropenic sepsis	245.60	13.15	236	90437	13531	34852727
Product dose omission issue	244.60	13.15	17	90656	119694	34746564
Drug abuse	241.05	13.15	3	90670	99093	34767165
Pneumonitis	238.79	13.15	362	90311	33516	34832742
Completed suicide	234.37	13.15	4	90669	98164	34768094
Off label use	226.97	13.15	1857	88816	417667	34448591
Metastases to central nervous system	213.02	13.15	174	90499	8031	34858227
Fall	197.75	13.15	143	90530	202742	34663516
Febrile bone marrow aplasia	196.31	13.15	166	90507	8043	34858215
Immune-mediated lung disease	185.43	13.15	88	90585	1503	34864755
Product use in unapproved indication	180.23	13.15	691	89982	116808	34749450
Haemoptysis	175.45	13.15	321	90352	34685	34831573
Overdose	155.30	13.15	25	90648	91034	34775224
Platelet count decreased	148.07	13.15	659	90014	119058	34747200
Renal salt-wasting syndrome	144.06	13.15	48	90625	297	34865961
Sepsis	140.27	13.15	823	89850	165738	34700520
Immune-mediated hepatic disorder	139.21	13.15	63	90610	960	34865298
Septic shock	135.27	13.15	452	90221	71382	34794876
Nasopharyngitis	131.77	13.15	14	90659	69954	34796304
Headache	131.65	13.15	198	90475	200437	34665821
White blood cell count decreased	129.96	13.15	541	90132	94904	34771354
Immune-mediated enterocolitis	128.96	13.15	84	90589	2715	34863543
Cytopenia	128.84	13.15	162	90511	12561	34853697
Depression	122.87	13.15	49	90624	97049	34769209
Radiation oesophagitis	121.41	13.15	45	90628	396	34865862
Skin toxicity	112.86	13.15	96	90577	4688	34861570
Drug interaction	111.31	13.15	265	90408	225681	34640577
Metastases to bone	111.14	13.15	146	90527	11824	34854434
Anxiety	110.62	13.15	60	90613	99368	34766890
Metastases to meninges	109.80	13.15	60	90613	1394	34864864
Weight increased	109.70	13.15	52	90621	92981	34773277
Pyrexia	106.86	13.15	1325	89348	331688	34534570
Aplasia	106.05	13.15	91	90582	4497	34861761
Dehydration	104.69	13.15	635	90038	129334	34736924
Tremor	103.95	13.15	42	90631	82545	34783713
Oesophagitis	100.98	13.15	147	90526	13114	34853144
Peripheral swelling	99.52	13.15	37	90636	76504	34789754
Colitis	98.91	13.15	267	90406	37483	34828775
General physical health deterioration	98.46	13.15	619	90054	127650	34738608
Intentional product misuse	97.56	13.15	5	90668	45606	34820652
Insomnia	97.52	13.15	76	90597	103831	34762427
Hospitalisation	96.14	13.15	16	90657	56886	34809372
Toxicity to various agents	95.49	13.15	239	90434	200123	34666135
Blood pressure increased	95.35	13.15	55	90618	88047	34778211
Joint swelling	94.45	13.15	20	90653	59870	34806388
Diffuse large B-cell lymphoma recurrent	91.32	13.15	72	90601	3156	34863102
Non-small cell lung cancer	90.77	13.15	78	90595	3862	34862396
Bradycardia	90.69	13.15	41	90632	75377	34790881
Decreased appetite	90.56	13.15	739	89934	165653	34700605
Feeling abnormal	88.41	13.15	27	90646	63208	34803050
Adrenal insufficiency	87.66	13.15	142	90531	13905	34852353
Arthralgia	86.42	13.15	196	90477	169845	34696413
Suicide attempt	84.58	13.15	4	90669	39112	34827146
Plasma cell myeloma	82.88	13.15	7	90666	42030	34824228
Pulmonary toxicity	81.74	13.15	90	90583	6057	34860201
Injection site pain	81.19	13.15	5	90668	39000	34827258
Hallucination	79.57	13.15	18	90655	51480	34814778
Pneumothorax	78.41	13.15	161	90512	18931	34847327
Tumour pseudoprogression	78.36	13.15	34	90639	466	34865792
Dizziness	78.27	13.15	297	90376	218224	34648034
Adrenocorticotropic hormone deficiency	76.88	13.15	41	90632	906	34865352
Cardiac failure congestive	76.74	13.15	62	90611	83208	34783050
Muscle spasms	76.73	13.15	50	90623	74951	34791307
Suicidal ideation	76.23	13.15	8	90665	40380	34825878
Hypothyroidism	75.16	13.15	167	90506	20735	34845523
Metastases to liver	73.15	13.15	129	90544	13534	34852724
Electrocardiogram QT prolonged	72.65	13.15	10	90663	40942	34825316
Neutropenic colitis	69.92	13.15	61	90612	3083	34863175
Abdominal discomfort	69.66	13.15	34	90639	59801	34806457
Pain in extremity	69.09	13.15	140	90533	126373	34739885
Musculoskeletal stiffness	68.83	13.15	18	90655	46662	34819596
Myocardial infarction	67.84	13.15	132	90541	120953	34745305
Metastases to lung	67.62	13.15	101	90572	9219	34857039
Neuropathy peripheral	66.44	13.15	406	90267	82857	34783401
Dysphagia	66.44	13.15	329	90344	62052	34804206
Bronchial fistula	66.01	13.15	23	90650	166	34866092
Acute myeloid leukaemia	65.72	13.15	146	90527	18124	34848134
Cardiotoxicity	65.44	13.15	77	90596	5571	34860687
Hypomagnesaemia	64.87	13.15	162	90511	21689	34844569
Cardiac disorder	64.80	13.15	16	90657	43110	34823148
Pneumatosis intestinalis	63.88	13.15	64	90609	3859	34862399
Influenza	62.90	13.15	25	90648	49641	34816617
Small intestinal perforation	62.65	13.15	49	90624	2122	34864136
Second primary malignancy	62.35	13.15	89	90584	7797	34858461
Asthma	61.85	13.15	17	90656	42639	34823619
Retinal pigment epitheliopathy	61.60	13.15	23	90650	207	34866051
Tracheo-oesophageal fistula	60.75	13.15	28	90645	446	34865812
Tubulointerstitial nephritis	60.46	13.15	154	90519	20870	34845388
Therapeutic product effect decreased	60.42	13.15	9	90664	34734	34831524
Stress	59.96	13.15	5	90668	30342	34835916
Tumour lysis syndrome	59.88	13.15	135	90538	16924	34849334
Blood glucose increased	59.83	13.15	51	90622	66667	34799591
Choroidal infarction	59.49	13.15	18	90655	77	34866181
Myelodysplastic syndrome	58.71	13.15	144	90529	19064	34847194
Anaplastic lymphoma kinase gene mutation	58.52	13.15	19	90654	107	34866151
Hypopituitarism	58.39	13.15	48	90625	2234	34864024
Respiratory failure	57.25	13.15	479	90194	108093	34758165
Somnolence	56.46	13.15	128	90545	110988	34755270
Memory impairment	56.19	13.15	21	90652	43297	34822961
Heart rate decreased	55.72	13.15	8	90665	31737	34834521
Loss of personal independence in daily activities	54.57	13.15	10	90663	33169	34833089
Diffuse large B-cell lymphoma refractory	53.49	13.15	36	90637	1230	34865028
Blood pressure fluctuation	53.26	13.15	3	90670	25246	34841012
Stomatitis	53.16	13.15	235	90438	42279	34823979
Hypertransaminasaemia	53.00	13.15	69	90604	5537	34860721
Drug reaction with eosinophilia and systemic symptoms	52.09	13.15	11	90662	33001	34833257
Disturbance in attention	52.03	13.15	4	90669	25941	34840317
Inappropriate schedule of product administration	51.84	13.15	51	90622	62245	34804013
Arthropathy	51.64	13.15	5	90668	26902	34839356
Immune-mediated hepatitis	51.33	13.15	44	90629	2171	34864087
Agitation	51.31	13.15	44	90629	57355	34808903
Gait disturbance	51.05	13.15	89	90584	85051	34781207
Blood lactate dehydrogenase increased	50.84	13.15	153	90520	22837	34843421
Pneumonia	50.72	13.15	1264	89409	361363	34504895
Hyperthyroidism	50.53	13.15	95	90578	10471	34855787
Aggression	50.35	13.15	19	90654	38945	34827313
Superior vena cava syndrome	50.33	13.15	27	90646	604	34865654
Anaphylactic shock	50.31	13.15	121	90552	15820	34850438
Lactic acidosis	50.15	13.15	14	90659	34758	34831500
Pain	49.14	13.15	320	90353	204355	34661903
Immune-mediated dermatitis	49.10	13.15	22	90651	327	34865931
Polyneuropathy	49.10	13.15	115	90558	14781	34851477
Pleural effusion	48.56	13.15	370	90303	81176	34785082
Coronary artery disease	48.32	13.15	33	90640	48272	34817986
Drug hypersensitivity	47.54	13.15	85	90588	80444	34785814
Hypoglycaemia	47.50	13.15	43	90630	54597	34811661
Sinusitis	47.47	13.15	24	90649	41378	34824880
Hypokalaemia	47.14	13.15	285	90388	57929	34808329
Immune-mediated renal disorder	47.06	13.15	17	90656	138	34866120
Disease recurrence	46.57	13.15	142	90531	21348	34844910
Nephrolithiasis	46.06	13.15	11	90662	30322	34835936
Rhabdomyolysis	45.84	13.15	66	90607	68097	34798161
Incorrect dose administered	45.68	13.15	24	90649	40491	34825767
Drug dependence	45.18	13.15	5	90668	24212	34842046
Vision blurred	45.18	13.15	32	90641	45931	34820327
Prostate cancer	43.95	13.15	24	90649	39625	34826633
Pulmonary radiation injury	43.46	13.15	13	90660	53	34866205
Wrong technique in product usage process	42.56	13.15	20	90653	35966	34830292
Gastrooesophageal reflux disease	41.98	13.15	23	90650	37901	34828357
Unevaluable event	41.93	13.15	16	90657	32574	34833684
Blood cholesterol increased	41.67	13.15	3	90670	20540	34845718
Radiation skin injury	40.94	13.15	25	90648	720	34865538
Portal venous gas	40.75	13.15	20	90653	369	34865889
Vomiting	40.66	13.15	883	89790	246738	34619520
Intestinal perforation	40.30	13.15	79	90594	8981	34857277
Serotonin syndrome	40.18	13.15	3	90670	19930	34846328
Mobility decreased	40.10	13.15	14	90659	30114	34836144
Upper respiratory tract infection	39.68	13.15	18	90655	33041	34833217
Pulmonary arteriopathy	39.63	13.15	13	90660	76	34866182
Amnesia	39.62	13.15	10	90663	26553	34839705
Alopecia	39.52	13.15	146	90527	24209	34842049
Treatment noncompliance	39.26	13.15	12	90661	28088	34838170
Paraneoplastic neurological syndrome	39.12	13.15	11	90662	34	34866224
Neoplasm recurrence	39.05	13.15	38	90635	2211	34864047
Recall phenomenon	38.85	13.15	22	90651	549	34865709
Gastrointestinal perforation	38.80	13.15	49	90624	3814	34862444
Hyponatraemia	37.97	13.15	354	90319	82337	34783921
Secondary adrenocortical insufficiency	37.78	13.15	31	90642	1439	34864819
Condition aggravated	37.73	13.15	318	90355	191878	34674380
Urticaria	37.57	13.15	65	90608	62312	34803946
Pulmonary vascular disorder	37.40	13.15	23	90650	671	34865587
Psoriatic arthropathy	37.16	13.15	4	90669	19794	34846464
Diabetes mellitus	37.15	13.15	40	90633	46833	34819425
Rheumatoid arthritis	37.08	13.15	27	90646	38211	34828047
Hypophysitis	36.68	13.15	37	90636	2249	34864009
Haematochezia	36.56	13.15	40	90633	46494	34819764
Influenza like illness	36.50	13.15	13	90660	27621	34838637
Hepatic function abnormal	36.42	13.15	218	90455	44145	34822113
Enteritis	36.22	13.15	71	90602	8071	34858187
Hypertension	36.01	13.15	207	90466	136236	34730022
Drug level increased	35.61	13.15	7	90666	22089	34844169
Extremity necrosis	35.52	13.15	34	90639	1938	34864320
Immune-mediated adrenal insuficiency	35.42	13.15	14	90659	149	34866109
Ototoxicity	34.43	13.15	33	90640	1884	34864374
B-cell lymphoma recurrent	34.30	13.15	23	90650	781	34865477
Foetal exposure during pregnancy	34.30	13.15	29	90644	38072	34828186
Abnormal behaviour	34.28	13.15	11	90662	24958	34841300
Eastern Cooperative Oncology Group performance status worsened	34.06	13.15	25	90648	983	34865275
Disseminated intravascular coagulation	33.92	13.15	129	90544	21687	34844571
Bicytopenia	33.61	13.15	36	90637	2348	34863910
Flatulence	33.57	13.15	7	90666	21191	34845067
Fanconi syndrome	33.56	13.15	31	90642	1689	34864569
Peripheral ischaemia	33.47	13.15	56	90617	5631	34860627
Pericarditis malignant	33.39	13.15	10	90663	41	34866217
Optic glioma	33.26	13.15	9	90664	23	34866235
Body height below normal	33.24	13.15	15	90658	227	34866031
Bronchopleural fistula	33.20	13.15	19	90654	484	34865774
Histiocytic necrotising lymphadenitis	33.20	13.15	8	90665	10	34866248
Psychotic disorder	33.17	13.15	11	90662	24441	34841817
Extraocular muscle disorder	32.79	13.15	14	90659	184	34866074
Immune-mediated hypothyroidism	32.71	13.15	16	90657	293	34865965
Juvenile melanoma benign	32.62	13.15	11	90662	71	34866187
Sleep disorder	32.56	13.15	21	90652	31667	34834591
Injury	32.41	13.15	7	90666	20680	34845578
Contusion	32.34	13.15	28	90645	36336	34829922
Dermatitis	32.19	13.15	74	90599	9394	34856864
Adverse drug reaction	32.18	13.15	18	90655	29324	34836934
Drug resistance	32.16	13.15	143	90530	25784	34840474
Kounis syndrome	31.99	13.15	36	90637	2482	34863776
Retinopathy proliferative	31.98	13.15	11	90662	76	34866182
Coma	31.93	13.15	43	90630	45635	34820623
Fluid retention	31.71	13.15	15	90658	26872	34839386
Autoimmune colitis	31.70	13.15	24	90649	990	34865268
Abdominal distension	31.66	13.15	65	90608	58427	34807831
Sleep apnoea syndrome	31.59	13.15	7	90666	20314	34845944
Road traffic accident	31.57	13.15	4	90669	17446	34848812
Depressed mood	31.38	13.15	6	90667	19311	34846947
Peripheral sensory neuropathy	31.36	13.15	60	90613	6700	34859558
Venoocclusive liver disease	31.32	13.15	66	90607	7900	34858358
Haemolytic uraemic syndrome	31.31	13.15	34	90639	2252	34864006
Hiccups	31.25	13.15	76	90597	10006	34856252
Lymphangiosis carcinomatosa	31.23	13.15	23	90650	909	34865349
Nausea	31.19	13.15	1125	89548	338783	34527475
Accidental overdose	31.18	13.15	7	90666	20133	34846125
Tracheal fistula	31.02	13.15	12	90661	120	34866138
Nephropathy toxic	30.93	13.15	87	90586	12501	34853757
Immune-mediated adverse reaction	30.69	13.15	19	90654	561	34865697
Product quality issue	30.59	13.15	4	90669	17031	34849227
Restlessness	30.38	13.15	14	90659	25468	34840790
Oesophagobronchial fistula	30.30	13.15	13	90660	173	34866085
Basal cell carcinoma	30.10	13.15	7	90666	19651	34846607
Cellulitis gangrenous	29.84	13.15	13	90660	180	34866078
Myalgia	29.59	13.15	115	90558	83995	34782263
Diarrhoea	29.57	13.15	1264	89409	388648	34477610
Rhinorrhoea	29.24	13.15	15	90658	25653	34840605
Pulmonary haemorrhage	29.13	13.15	75	90598	10229	34856029
Metastases to spleen	29.05	13.15	17	90656	452	34865806
Renal tubular disorder	29.05	13.15	47	90626	4596	34861662
Lung adenocarcinoma	28.84	13.15	47	90626	4624	34861634
Irritability	28.77	13.15	14	90659	24676	34841582
Cerebrovascular accident	28.54	13.15	118	90555	84693	34781565
Osteoarthritis	28.50	13.15	9	90664	20633	34845625
Back pain	28.38	13.15	192	90481	121597	34744661
Myocarditis	28.33	13.15	89	90584	13593	34852665
Blood pressure systolic increased	28.33	13.15	12	90661	22940	34843318
Bronchospasm	28.19	13.15	76	90597	10655	34855603
Pulmonary embolism	28.10	13.15	356	90317	89390	34776868
Haemorrhage	27.88	13.15	57	90616	51313	34814945
Delayed puberty	27.82	13.15	13	90660	214	34866044
Nephritis	27.71	13.15	33	90640	2418	34863840
Heart rate irregular	27.70	13.15	4	90669	15803	34850455
Psoriasis	27.68	13.15	36	90637	38776	34827482
Immune-mediated myocarditis	27.64	13.15	20	90653	769	34865489
Thrombotic microangiopathy	27.64	13.15	75	90598	10555	34855703
Retinal degeneration	27.55	13.15	17	90656	499	34865759
Administration site extravasation	27.49	13.15	18	90655	587	34865671
Dyskinesia	27.21	13.15	12	90661	22401	34843857
Oesophagopleural fistula	27.10	13.15	9	90664	55	34866203
Lichenoid keratosis	27.10	13.15	33	90640	2475	34863783
Nasal congestion	26.98	13.15	13	90660	23044	34843214
Metastases to muscle	26.87	13.15	13	90660	232	34866026
Tumour necrosis	26.67	13.15	24	90649	1264	34864994
Chronic kidney disease	26.63	13.15	41	90632	41169	34825089
Gastrointestinal toxicity	26.54	13.15	34	90639	2685	34863573
Weight decreased	26.51	13.15	311	90362	175990	34690268
Hypophagia	26.48	13.15	128	90545	23894	34842364
Thrombophlebitis migrans	26.39	13.15	12	90661	185	34866073
Cardiac arrest	26.38	13.15	144	90529	96015	34770243
Myositis	26.37	13.15	80	90593	11990	34854268
Surgery	26.21	13.15	3	90670	14154	34852104
Platelet count abnormal	26.13	13.15	35	90638	2887	34863371
Therapy cessation	26.08	13.15	6	90667	16967	34849291
Hypersensitivity pneumonitis	25.93	13.15	26	90647	1569	34864689
Balance disorder	25.74	13.15	41	90632	40613	34825645
Encephalitis enteroviral	25.67	13.15	11	90662	146	34866112
Wound	25.50	13.15	4	90669	14860	34851398
Hypercreatininaemia	25.47	13.15	16	90657	485	34865773
Metastatic neoplasm	25.41	13.15	35	90638	2965	34863293
Metastases to adrenals	25.30	13.15	21	90652	991	34865267
International normalised ratio increased	25.27	13.15	53	90620	47274	34818984
Radiation mucositis	25.07	13.15	12	90661	209	34866049
Hypocalcaemia	25.05	13.15	127	90546	24162	34842096
Head injury	24.93	13.15	8	90665	18152	34848106
Cytokine storm	24.88	13.15	18	90655	692	34865566
Eosinophilia	24.80	13.15	19	90654	26203	34840055
Benign prostatic hyperplasia	24.64	13.15	4	90669	14491	34851767
Inappropriate antidiuretic hormone secretion	24.63	13.15	81	90592	12672	34853586
Pseudocellulitis	24.50	13.15	8	90665	46	34866212
Metastases to lymph nodes	24.48	13.15	44	90629	4684	34861574
Pruritus	24.33	13.15	243	90430	141738	34724520
Adrenal disorder	24.16	13.15	21	90652	1056	34865202
Mental disorder	24.13	13.15	5	90668	15204	34851054
Drug intolerance	23.92	13.15	77	90596	59493	34806765
Immune-mediated pancreatitis	23.73	13.15	10	90663	127	34866131
Encephalopathy	23.73	13.15	165	90508	35154	34831104
Immune-mediated thyroiditis	23.66	13.15	10	90663	128	34866130
Synovitis	23.65	13.15	4	90669	14062	34852196
Immune-mediated cholangitis	23.52	13.15	10	90663	130	34866128
Autoimmune haemolytic anaemia	23.48	13.15	42	90631	4454	34861804
Metastases to retroperitoneum	23.40	13.15	12	90661	244	34866014
Performance status decreased	23.37	13.15	40	90633	4097	34862161
Jaundice	23.32	13.15	29	90644	31853	34834405
Metastasis	23.32	13.15	40	90633	4104	34862154
Incorrect route of product administration	23.31	13.15	5	90668	14840	34851418
Short stature	23.27	13.15	9	90664	90	34866168
Extrapyramidal disorder	23.18	13.15	3	90670	12877	34853381
Noninfectious myelitis	23.18	13.15	6	90667	12	34866246
Oropharyngeal squamous cell carcinoma	22.86	13.15	11	90662	194	34866064
Ameloblastoma	22.84	13.15	9	90664	95	34866163
Tumour haemorrhage	22.78	13.15	33	90640	2929	34863329
Delusion	22.61	13.15	3	90670	12632	34853626
Radiation dysphagia	22.44	13.15	5	90668	3	34866255
Rhabdomyosarcoma recurrent	22.27	13.15	9	90664	102	34866156
Opsoclonus myoclonus	22.14	13.15	8	90665	65	34866193
Burning sensation	22.09	13.15	10	90663	18384	34847874
Pericardial effusion	22.06	13.15	124	90549	24538	34841720
Hepatic steatosis	22.03	13.15	10	90663	18352	34847906
Palpitations	22.01	13.15	44	90629	39942	34826316
Metastases to skin	21.89	13.15	14	90659	438	34865820
Dyspnoea	21.88	13.15	1190	89483	375592	34490666
Cytokine release syndrome	21.79	13.15	117	90556	22760	34843498
Neutropenic infection	21.79	13.15	23	90650	1475	34864783
Emotional distress	21.75	13.15	6	90667	15020	34851238
Iris neovascularisation	21.73	13.15	6	90667	17	34866241
Non-small cell lung cancer metastatic	21.69	13.15	16	90657	634	34865624
Laboratory test abnormal	21.66	13.15	13	90660	20378	34845880
Angioedema	21.55	13.15	40	90633	37334	34828924
Metastases to pleura	21.50	13.15	14	90659	452	34865806
Carbamoyl phosphate synthetase deficiency	21.47	13.15	6	90667	18	34866240
EGFR gene mutation	21.27	13.15	10	90663	167	34866091
Fulminant type 1 diabetes mellitus	21.26	13.15	18	90655	873	34865385
Post-acute COVID-19 syndrome	21.22	13.15	10	90663	168	34866090
Medication error	21.18	13.15	21	90652	25544	34840714
Guillain-Barre syndrome	21.17	13.15	48	90625	6039	34860219
Flagellate dermatitis	21.04	13.15	8	90665	76	34866182
Meningitis tuberculous	20.94	13.15	16	90657	669	34865589
Hallucination, visual	20.86	13.15	10	90663	17781	34848477
Bronchitis	20.76	13.15	49	90624	41914	34824344
Frequent bowel movements	20.71	13.15	4	90669	12783	34853475
Acute myelomonocytic leukaemia	20.70	13.15	9	90664	124	34866134
Hyperkalaemia	20.67	13.15	101	90572	69288	34796970
Subdural haematoma	20.35	13.15	14	90659	20407	34845851
Cholangitis	20.32	13.15	59	90614	8630	34857628
Immune thrombocytopenia	20.32	13.15	61	90612	9091	34857167
Blood creatine phosphokinase increased	20.16	13.15	55	90618	44802	34821456
Injection site erythema	20.13	13.15	8	90665	15891	34850367
Metabolic acidosis	20.05	13.15	53	90620	43627	34822631
Cataract	20.03	13.15	23	90650	26163	34840095
Vena cava thrombosis	20.01	13.15	20	90653	1202	34865056
Pleurocutaneous fistula	19.91	13.15	7	90666	52	34866206
Neurotoxicity	19.88	13.15	96	90577	17914	34848344
Retroperitoneal lymphadenopathy	19.86	13.15	17	90656	837	34865421
Acquired tracheo-oesophageal fistula	19.85	13.15	8	90665	90	34866168
Lung infiltration	19.80	13.15	76	90597	12829	34853429
Contraindicated product administered	19.76	13.15	16	90657	21465	34844793
Autoimmune neutropenia	19.59	13.15	11	90662	270	34865988
Angina pectoris	19.51	13.15	32	90641	31331	34834927
Malaise	19.46	13.15	352	90321	185473	34680785
Amoebic colitis	19.39	13.15	8	90665	96	34866162
Lung abscess	19.34	13.15	29	90644	2656	34863602
Neuroblastoma recurrent	19.21	13.15	9	90664	149	34866109
Dermatomyositis	19.20	13.15	20	90653	1263	34864995
Visual impairment	19.19	13.15	40	90633	35762	34830496
Gastritis bacterial	19.08	13.15	10	90663	213	34866045
Viral infection	19.05	13.15	11	90662	17612	34848646
Hepatic enzyme increased	19.04	13.15	46	90627	39034	34827224
Gastrointestinal mucosal disorder	18.98	13.15	12	90661	368	34865890
Acute febrile neutrophilic dermatosis	18.94	13.15	20	90653	1283	34864975
Stress cardiomyopathy	18.93	13.15	25	90648	2034	34864224
Oesophageal fistula	18.92	13.15	11	90662	289	34865969
Herpes zoster reactivation	18.81	13.15	11	90662	292	34865966
Haemophagocytic lymphohistiocytosis	18.77	13.15	75	90598	12898	34853360
Asthenia	18.73	13.15	796	89877	244455	34621803
Pulmonary oedema	18.69	13.15	62	90611	47467	34818791
Flushing	18.66	13.15	146	90527	32274	34833984
Basal cell naevus syndrome	18.60	13.15	6	90667	33	34866225
Joint stiffness	18.48	13.15	3	90670	10870	34855388
Non-small cell lung cancer recurrent	18.45	13.15	6	90667	34	34866224
Osteoporosis	18.45	13.15	5	90668	12663	34853595
Rectal haemorrhage	18.35	13.15	49	90624	40200	34826058
Full blood count abnormal	18.33	13.15	13	90660	18655	34847603
Acquired gene mutation	18.29	13.15	20	90653	1335	34864923
Pulmonary arterial hypertension	18.24	13.15	57	90616	8682	34857576
Abdominal pain upper	18.02	13.15	110	90563	71380	34794878
Gastric disorder	17.95	13.15	5	90668	12436	34853822
Venoocclusive disease	17.91	13.15	29	90644	2838	34863420
Injection site swelling	17.86	13.15	4	90669	11523	34854735
Photosensitivity reaction	17.84	13.15	3	90670	10591	34855667
Confusional state	17.75	13.15	265	90408	143895	34722363
Myoclonus	17.69	13.15	8	90665	14717	34851541
Metastases to kidney	17.67	13.15	11	90662	328	34865930
Muscle rigidity	17.66	13.15	3	90670	10515	34855743
Agranulocytosis	17.63	13.15	114	90559	23707	34842551
Pancreatic toxicity	17.63	13.15	6	90667	40	34866218
Cardiomegaly	17.61	13.15	9	90664	15429	34850829
Cellulitis	17.60	13.15	74	90599	52877	34813381
Vascular access site swelling	17.60	13.15	4	90669	3	34866255
Electrolyte imbalance	17.50	13.15	79	90594	14333	34851925
Gastrointestinal haemorrhage	17.50	13.15	146	90527	88331	34777927
Hepatocellular injury	17.49	13.15	108	90565	22103	34844155
Depressed level of consciousness	17.46	13.15	55	90618	42786	34823472
Rash maculo-papular	17.42	13.15	130	90543	28321	34837937
Adenoviral hepatitis	17.28	13.15	13	90660	531	34865727
Chromaturia	17.27	13.15	8	90665	14512	34851746
Posterior reversible encephalopathy syndrome	17.27	13.15	61	90612	9893	34856365
Paraneoplastic syndrome	17.09	13.15	13	90660	540	34865718
Oral papule	17.07	13.15	4	90669	4	34866254
Gliosis	17.03	13.15	9	90664	195	34866063
Dysentery	16.93	13.15	11	90662	354	34865904
Swelling	16.84	13.15	55	90618	42311	34823947
Skin discolouration	16.78	13.15	13	90660	17832	34848426
Erythema multiforme	16.76	13.15	55	90618	8594	34857664
Paraneoplastic rash	16.75	13.15	7	90666	87	34866171
Diabetes mellitus inadequate control	16.68	13.15	7	90666	13457	34852801
Iris atrophy	16.67	13.15	7	90666	88	34866170
Cardiac tamponade	16.64	13.15	40	90633	5226	34861032
Pneumonia adenoviral	16.60	13.15	11	90662	366	34865892
Product administration error	16.56	13.15	11	90662	16333	34849925
Faeces discoloured	16.49	13.15	9	90664	14869	34851389
Cardiac dysfunction	16.48	13.15	25	90648	2313	34863945
Bladder cancer	16.43	13.15	11	90662	16267	34849991
Pulmonary hypertension	16.42	13.15	18	90655	20906	34845352
Intervertebral disc protrusion	16.37	13.15	3	90670	9953	34856305
Respiratory depression	16.37	13.15	11	90662	16234	34850024
Appendicitis	16.35	13.15	9	90664	14798	34851460
Skin laceration	16.32	13.15	6	90667	12503	34853755
Wheezing	16.28	13.15	54	90619	41348	34824910
Clostridium difficile infection	16.26	13.15	15	90658	18883	34847375
Malignant pleural effusion	16.25	13.15	20	90653	1516	34864742
Resorption bone increased	16.24	13.15	9	90664	215	34866043
Blood glucose decreased	16.21	13.15	7	90666	13230	34853028
Adenovirus reactivation	16.17	13.15	9	90664	217	34866041
Adenomatous polyposis coli	16.09	13.15	8	90665	152	34866106
Immune-mediated hyperthyroidism	16.07	13.15	6	90667	54	34866204
Liver disorder	16.01	13.15	143	90530	32854	34833404
Oesophageal pain	15.98	13.15	15	90658	834	34865424
Laryngeal pain	15.97	13.15	27	90646	2737	34863521
Malignant transformation	15.95	13.15	15	90658	836	34865422
Pelvic mass	15.91	13.15	9	90664	224	34866034
Oesophageal stenosis	15.90	13.15	21	90652	1709	34864549
Mucosal hyperaemia	15.89	13.15	5	90668	25	34866233
Right ventricular ejection fraction decreased	15.78	13.15	6	90667	57	34866201
Immune-mediated encephalitis	15.70	13.15	9	90664	230	34866028
Lung squamous cell carcinoma metastatic	15.69	13.15	6	90667	58	34866200
Hepatitis	15.66	13.15	111	90562	23793	34842465
Cytomegalovirus chorioretinitis	15.60	13.15	31	90642	3558	34862700
Squamous cell carcinoma of lung	15.59	13.15	22	90651	1907	34864351
Transient ischaemic attack	15.53	13.15	30	90643	27583	34838675
Enterocolitis	15.52	13.15	51	90622	7975	34858283
Blister	15.49	13.15	22	90651	22836	34843422
Infectious pleural effusion	15.45	13.15	25	90648	2445	34863813
Odynophagia	15.41	13.15	40	90633	5481	34860777
Neuroendocrine tumour of the lung metastatic	15.39	13.15	7	90666	108	34866150
Embolism	15.36	13.15	50	90623	7779	34858479
Mania	15.35	13.15	3	90670	9508	34856750
Pollakiuria	15.35	13.15	17	90656	19657	34846601
Empyema	15.35	13.15	29	90644	3207	34863051
Thrombosis	15.28	13.15	73	90600	50385	34815873
Pulmonary veno-occlusive disease	15.28	13.15	12	90661	523	34865735
Renal tubular dysfunction	15.25	13.15	11	90662	421	34865837
Aspartate aminotransferase abnormal	15.15	13.15	14	90659	763	34865495
Laryngeal necrosis	15.14	13.15	4	90669	9	34866249
Lymphadenopathy mediastinal	15.13	13.15	25	90648	2488	34863770
Skin cancer	15.12	13.15	4	90669	10293	34855965
Cachexia	15.11	13.15	47	90626	7139	34859119
Pancreatitis	15.11	13.15	51	90622	38840	34827418
Vasogenic cerebral oedema	15.10	13.15	13	90660	645	34865613
Hip fracture	15.10	13.15	6	90667	11919	34854339
Poikiloderma	15.03	13.15	8	90665	176	34866082
Papilloedema	15.02	13.15	26	90647	2687	34863571
Miller Fisher syndrome	14.99	13.15	7	90666	115	34866143
Lung opacity	14.92	13.15	24	90649	2335	34863923
Proteinuria	14.90	13.15	91	90582	18551	34847707
Pulmonary cavitation	14.83	13.15	15	90658	915	34865343
Full blood count decreased	14.82	13.15	15	90658	18073	34848185
Urosepsis	14.69	13.15	69	90604	12730	34853528
Arteriosclerosis coronary artery	14.67	13.15	7	90666	12478	34853780
Salivary gland cancer stage IV	14.60	13.15	5	90668	34	34866224
Limb injury	14.60	13.15	6	90667	11683	34854575
Aortic injury	14.57	13.15	4	90669	11	34866247
Swollen tongue	14.57	13.15	10	90663	14595	34851663
Epistaxis	14.54	13.15	222	90451	58029	34808229
Hyperpyrexia	14.50	13.15	26	90647	2762	34863496
Blastic plasmacytoid dendritic cell neoplasia	14.47	13.15	6	90667	73	34866185
Cardiac failure	14.46	13.15	159	90514	91089	34775169
Drug ineffective	14.40	13.15	1006	89667	455745	34410513
Encephalitis autoimmune	14.33	13.15	13	90660	692	34865566
Q fever	14.32	13.15	7	90666	128	34866130
Radiation associated pain	14.32	13.15	4	90669	12	34866246
Pyopneumothorax	14.25	13.15	6	90667	76	34866182
Choroidal dystrophy	14.24	13.15	5	90668	37	34866221
Food protein-induced enterocolitis syndrome	14.24	13.15	5	90668	37	34866221
Cholangitis sclerosing	14.23	13.15	18	90655	1403	34864855
Chest discomfort	14.22	13.15	83	90590	54447	34811811
Eyelid oedema	14.18	13.15	37	90636	5087	34861171
Cystoid macular oedema	14.17	13.15	13	90660	702	34865556
Ileus	14.13	13.15	82	90591	16417	34849841
Dysstasia	14.08	13.15	7	90666	12188	34854070
Gait inability	14.04	13.15	20	90653	20738	34845520
Occipital neuralgia	14.01	13.15	5	90668	39	34866219
Osteosarcoma	14.01	13.15	9	90664	284	34865974
Swelling face	13.98	13.15	24	90649	23081	34843177
Obesity	13.97	13.15	8	90665	12870	34853388
Transaminases increased	13.93	13.15	118	90555	26705	34839553
Small cell carcinoma	13.84	13.15	7	90666	138	34866120
Immune-mediated neuropathy	13.80	13.15	5	90668	41	34866217
Arthritis	13.67	13.15	39	90634	31307	34834951
Autoimmune hepatitis	13.65	13.15	33	90640	4327	34861931
Fanconi syndrome acquired	13.62	13.15	21	90652	1970	34864288
Thyroiditis	13.55	13.15	23	90650	2339	34863919
Palmar erythema	13.52	13.15	9	90664	302	34865956
Vitreous haemorrhage	13.48	13.15	23	90650	2350	34863908
Infected neoplasm	13.46	13.15	6	90667	88	34866170
Iron deficiency anaemia	13.40	13.15	5	90668	10324	34855934
Chloroma	13.32	13.15	11	90662	515	34865743
Embolism venous	13.31	13.15	18	90655	1498	34864760
Limb discomfort	13.28	13.15	6	90667	11041	34855217
Pancreatic enzymes increased	13.21	13.15	12	90661	640	34865618
Immune-mediated gastritis	13.20	13.15	5	90668	47	34866211
Oedema peripheral	13.15	13.15	225	90448	119587	34746671

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	2720.92	12.05	3069	190815	227930	79322574
Malignant neoplasm progression	2439.71	12.05	2268	191616	133722	79416782
Neutropenia	2355.41	12.05	3183	190701	284527	79265977
Thrombocytopenia	1904.77	12.05	2757	191127	262502	79288002
Disease progression	1796.27	12.05	2225	191659	182137	79368367
Anaemia	1662.41	12.05	3463	190421	441552	79108952
Myelosuppression	1600.48	12.05	1075	192809	39221	79511283
Pancytopenia	1478.60	12.05	1915	191969	163830	79386674
Neutrophil count decreased	1348.33	12.05	1388	192496	92571	79457933
Mucosal inflammation	745.43	12.05	919	192965	74661	79475843
Haematotoxicity	723.53	12.05	458	193426	15061	79535443
Bone marrow failure	709.19	12.05	742	193142	50365	79500139
Leukopenia	697.81	12.05	1115	192769	115398	79435106
Neutropenic sepsis	650.43	12.05	534	193350	26530	79523974
Acute myeloid leukaemia	642.88	12.05	561	193323	30324	79520180
Therapy partial responder	640.25	12.05	443	193441	16954	79533550
Neoplasm progression	609.95	12.05	689	193195	50993	79499511
Neuropathy peripheral	589.48	12.05	1154	192730	140151	79410353
Completed suicide	569.53	12.05	5	193879	245762	79304742
Erythema	548.44	12.05	1479	192405	221811	79328693
Joint swelling	526.14	12.05	48	193836	288598	79261906
Platelet count decreased	523.54	12.05	1334	192550	193330	79357174
Pain	472.01	12.05	613	193271	703189	78847315
Myelodysplastic syndrome	465.79	12.05	465	193419	29836	79520668
Product dose omission issue	456.94	12.05	39	193845	247498	79303006
Fall	448.43	12.05	320	193564	487309	79063195
White blood cell count decreased	434.15	12.05	1219	192665	187069	79363435
Nasopharyngitis	404.50	12.05	66	193818	253815	79296689
Flushing	403.80	12.05	750	193134	87518	79462986
Arthralgia	401.93	12.05	480	193404	571323	78979181
Metastases to central nervous system	395.31	12.05	324	193560	16051	79534453
Weight increased	394.09	12.05	95	193789	277291	79273213
Radiation pneumonitis	393.58	12.05	192	193692	3741	79546763
Interstitial lung disease	391.06	12.05	853	193031	111747	79438757
Anaphylactic shock	376.33	12.05	451	193433	35545	79514959
Headache	366.91	12.05	643	193241	653129	78897375
Drug abuse	360.70	12.05	7	193877	162684	79387820
Pneumonitis	352.56	12.05	574	193310	60286	79490218
Rheumatoid arthritis	348.63	12.05	47	193837	208423	79342081
Synovitis	340.35	12.05	5	193879	150729	79399775
Peripheral swelling	330.82	12.05	121	193763	269496	79281008
Overdose	321.55	12.05	36	193848	184170	79366334
Febrile bone marrow aplasia	315.08	12.05	258	193626	12762	79537742
Metastases to liver	312.93	12.05	365	193519	27949	79522555
Therapeutic product effect decreased	310.17	12.05	23	193861	163840	79386664
Arthropathy	300.76	12.05	38	193846	177073	79373431
Second primary malignancy	299.24	12.05	261	193623	14089	79536415
Musculoskeletal stiffness	293.69	12.05	39	193845	174969	79375535
Contraindicated product administered	284.74	12.05	27	193857	157511	79392993
Hypokalaemia	284.54	12.05	883	193001	143157	79407347
Sinusitis	283.44	12.05	64	193820	195437	79355067
Hypomagnesaemia	269.72	12.05	441	193443	46470	79504034
Ototoxicity	266.55	12.05	139	193745	3135	79547369
Product use in unapproved indication	263.58	12.05	1256	192628	249103	79301401
Renal salt-wasting syndrome	262.91	12.05	89	193795	627	79549877
Vomiting	262.89	12.05	2620	191264	663208	78887296
Colitis	259.72	12.05	560	193324	72747	79477757
Dehydration	258.31	12.05	1241	192643	246946	79303558
Nausea	256.63	12.05	3494	190390	953702	78596802
Swelling	252.98	12.05	105	193779	216606	79333898
Metastases to bone	251.95	12.05	304	193580	24123	79526381
Metastases to lung	247	12.05	261	193623	17902	79532602
Abdominal discomfort	245.64	12.05	153	193731	250574	79299930
Sepsis	244.39	12.05	1296	192588	268132	79282372
Immune-mediated enterocolitis	243.90	12.05	150	193734	4680	79545824
Immune-mediated hepatic disorder	232.20	12.05	101	193783	1493	79549011
Injection site pain	230.06	12.05	24	193860	129814	79420690
Hand deformity	224.38	12.05	6	193878	103913	79446591
Skin toxicity	216.55	12.05	172	193712	8142	79542362
Peripheral sensory neuropathy	211.39	12.05	206	193678	12827	79537677
Off label use	209.31	12.05	3227	190657	903988	78646516
Glossodynia	209.16	12.05	10	193874	103327	79447177
Pyrexia	207.71	12.05	2540	191344	676169	78874335
Depression	207.24	12.05	136	193748	216654	79333850
Immune-mediated lung disease	206.04	12.05	104	193780	2186	79548318
Insomnia	201.00	12.05	180	193704	244990	79305514
Wound	199.47	12.05	24	193860	116155	79434349
Dyspnoea	198.18	12.05	3050	190834	853975	78696529
Drug intolerance	196.80	12.05	211	193673	263908	79286596
Tumour lysis syndrome	191.97	12.05	263	193621	23676	79526828
Hepatic enzyme increased	187.89	12.05	105	193779	182505	79367999
General physical health deterioration	187.49	12.05	1228	192656	274010	79276494
Polyneuropathy	187.17	12.05	261	193623	23890	79526614
Hypothyroidism	186.43	12.05	401	193483	51991	79498513
Systemic lupus erythematosus	183.06	12.05	36	193848	121113	79429391
Pain in extremity	181.78	12.05	384	193500	364154	79186350
Aplasia	178.89	12.05	150	193734	7670	79542834
Condition aggravated	178.44	12.05	623	193261	500501	79050003
Toxicity to various agents	175.53	12.05	488	193396	421052	79129452
Proteinuria	175.37	12.05	297	193587	32205	79518299
Contusion	175.34	12.05	71	193813	148705	79401799
Influenza	171.42	12.05	51	193833	129555	79420949
Mobility decreased	171.11	12.05	43	193841	122132	79428372
Psoriatic arthropathy	170.29	12.05	4	193880	77995	79472509
Blood cholesterol increased	169.76	12.05	8	193876	83712	79466792
Suicide attempt	167.92	12.05	8	193876	82924	79467580
Intentional product misuse	167.53	12.05	18	193866	95147	79455357
Haemoptysis	167.41	12.05	400	193484	55599	79494905
Loss of personal independence in daily activities	164.75	12.05	26	193858	102554	79447950
Metastases to lymph nodes	164.27	12.05	162	193722	10235	79540269
Septic shock	164.04	12.05	662	193222	122139	79428365
Oesophagitis	161.31	12.05	244	193640	24045	79526459
Maternal exposure during pregnancy	161.16	12.05	65	193819	136473	79414031
Hospitalisation	160.46	12.05	20	193864	94216	79456288
Diarrhoea	157.45	12.05	3007	190877	877482	78673022
Decreased appetite	157.39	12.05	1393	192491	341025	79209479
Metastases to meninges	157.22	12.05	102	193782	3499	79547005
Discomfort	156.29	12.05	55	193829	125562	79424942
Drug interaction	155.34	12.05	505	193379	414678	79135826
Muscle spasms	154.63	12.05	119	193765	174611	79375893
Blister	154.43	12.05	49	193835	119427	79431077
Drug ineffective	153.64	12.05	1787	192097	1079126	78471378
Neutropenic colitis	152.79	12.05	120	193764	5587	79544917
Gastrointestinal perforation	149.30	12.05	122	193762	6015	79544489
Migraine	143.19	12.05	21	193863	87472	79463032
Asthma	142.86	12.05	75	193809	135020	79415484
Posterior reversible encephalopathy syndrome	141.58	12.05	240	193644	26041	79524463
Stress	140.28	12.05	15	193869	79597	79470907
Drug resistance	137.64	12.05	312	193572	41901	79508603
Blood pressure fluctuation	137.49	12.05	6	193878	67139	79483365
Somnolence	135.44	12.05	233	193651	238748	79311756
Feeling abnormal	135.13	12.05	113	193771	159086	79391418
Radiation oesophagitis	135.08	12.05	54	193830	637	79549867
Anxiety	134.81	12.05	249	193635	248263	79302241
Pleural effusion	134.43	12.05	703	193181	144559	79405945
Fibromyalgia	134.27	12.05	5	193879	64335	79486169
Injury	133.04	12.05	16	193868	77480	79473024
Cytopenia	132.86	12.05	203	193681	20180	79530324
Irritable bowel syndrome	132.85	12.05	4	193880	62237	79488267
Suicidal ideation	128.04	12.05	17	193867	76323	79474181
Ovarian cancer recurrent	127.68	12.05	46	193838	398	79550106
Recall phenomenon	127.42	12.05	60	193824	1077	79549427
Hypertransaminasaemia	127.22	12.05	151	193733	11773	79538731
Memory impairment	122.68	12.05	59	193825	111675	79438829
Non-small cell lung cancer	121.31	12.05	110	193774	6250	79544254
Pneumothorax	121.17	12.05	234	193650	28089	79522415
Injection site erythema	120.75	12.05	22	193862	78175	79472329
Cardiac failure congestive	119.72	12.05	102	193782	142300	79408204
Immune-mediated hepatitis	118.09	12.05	86	193798	3570	79546934
Choroidal infarction	118.04	12.05	35	193849	149	79550355
Osteoarthritis	117.93	12.05	33	193851	87276	79463228
Dizziness	117.79	12.05	773	193111	525668	79024836
Pulmonary embolism	117.44	12.05	767	193117	170887	79379617
Disease recurrence	116.98	12.05	301	193583	43808	79506696
Pericarditis	116.04	12.05	54	193830	104182	79446322
Duodenal ulcer perforation	115.32	12.05	13	193871	66198	79484306
Bronchitis	113.02	12.05	91	193793	130553	79419951
Bradycardia	112.86	12.05	98	193786	135459	79415045
Drug hypersensitivity	112.11	12.05	363	193521	298553	79251951
Exposure during pregnancy	111.65	12.05	53	193831	101079	79449425
Cardiotoxicity	111.27	12.05	143	193741	12096	79538408
Bronchospasm	105.87	12.05	205	193679	24654	79525850
Immune-mediated dermatitis	104.66	12.05	43	193841	547	79549957
Muscle injury	104.08	12.05	3	193881	48558	79501946
Arthritis	103.20	12.05	77	193807	114803	79435701
Small intestinal perforation	102.97	12.05	76	193808	3221	79547283
Metastasis	102.79	12.05	104	193780	6776	79543728
Hallucination	102.51	12.05	40	193844	85705	79464799
Palmar erythema	102.23	12.05	62	193822	1885	79548619
Ileus	101.83	12.05	208	193676	26003	79524501
Diffuse large B-cell lymphoma recurrent	101.02	12.05	83	193801	4124	79546380
EGFR gene mutation	100.31	12.05	39	193845	425	79550079
Type I hypersensitivity	99.85	12.05	84	193800	4314	79546190
Psoriasis	98.82	12.05	47	193837	89540	79460964
Hyperthyroidism	98.09	12.05	186	193698	22023	79528481
Gait disturbance	98.03	12.05	225	193659	207281	79343223
Injection site swelling	97.20	12.05	4	193880	47128	79503376
Dysphagia	96.22	12.05	566	193318	121570	79428934
Metastases to peritoneum	96.17	12.05	82	193802	4290	79546214
Sedation	96.14	12.05	8	193876	51887	79498617
Renal tubular disorder	95	12.05	97	193787	6389	79544115
Lymphangiosis carcinomatosa	94.01	12.05	61	193823	2093	79548411
Tumour pseudoprogression	92.36	12.05	41	193843	638	79549866
Heart rate decreased	92.36	12.05	28	193856	70288	79480216
Acquired gene mutation	92.00	12.05	61	193823	2172	79548332
Product use issue	91.65	12.05	237	193647	209585	79340919
Inappropriate schedule of product administration	91.62	12.05	114	193770	133514	79416990
Anaphylactic reaction	91.49	12.05	425	193459	83318	79467186
Electrocardiogram QT prolonged	91.45	12.05	53	193831	90333	79460171
Incorrect dose administered	91.19	12.05	36	193848	76594	79473910
Adrenal insufficiency	91.14	12.05	209	193675	28278	79522226
Red blood cell sedimentation rate increased	88.18	12.05	6	193878	45936	79504568
C-reactive protein abnormal	88.12	12.05	8	193876	48359	79502145
Neurotoxicity	87.35	12.05	223	193661	32295	79518209
Embolism	86.58	12.05	136	193748	13846	79536658
Nasal congestion	86.23	12.05	39	193845	76513	79473991
Thrombotic microangiopathy	85.49	12.05	166	193718	20003	79530501
Impaired healing	85.05	12.05	54	193830	87601	79462903
Nephrolithiasis	84.45	12.05	14	193870	53277	79497227
Wheezing	83.73	12.05	96	193788	116568	79433936
Hypopituitarism	83.59	12.05	68	193816	3331	79547173
Adrenocorticotropic hormone deficiency	82.91	12.05	48	193836	1337	79549167
Gastrooesophageal reflux disease	82.44	12.05	79	193805	104167	79446337
Tremor	82.30	12.05	182	193702	169901	79380603
Plasma cell myeloma	82.19	12.05	15	193869	53244	79497260
Myocardial infarction	81.93	12.05	206	193678	183923	79366581
Drug reaction with eosinophilia and systemic symptoms	81.85	12.05	27	193857	64217	79486287
Sleep disorder	81.47	12.05	54	193830	85623	79464881
Hepatic function abnormal	80.58	12.05	372	193512	72735	79477769
Feeling hot	80.49	12.05	323	193561	59411	79491093
Metastatic neoplasm	80.46	12.05	79	193805	4963	79545541
Respiratory failure	80.40	12.05	731	193153	180180	79370324
Asthenia	80.20	12.05	1715	192169	509974	79040530
Disseminated intravascular coagulation	79.45	12.05	229	193655	35613	79514891
Bronchial fistula	79.42	12.05	27	193857	193	79550311
Hydronephrosis	79.35	12.05	148	193736	17306	79533198
Immune-mediated pancreatitis	78.63	12.05	29	193855	270	79550234
Immune-mediated hypothyroidism	77.43	12.05	36	193848	627	79549877
Tracheo-oesophageal fistula	77.35	12.05	35	193849	571	79549933
Myocarditis	76.90	12.05	166	193718	21567	79528937
Drug dependence	76.32	12.05	6	193878	40763	79509741
Enterocolitis	76.15	12.05	131	193753	14381	79536123
Serotonin syndrome	75.57	12.05	10	193874	45017	79505487
Hypocalcaemia	75.49	12.05	280	193604	49644	79500860
Injection site reaction	75.31	12.05	20	193864	54765	79495739
Treatment failure	74.87	12.05	192	193692	170294	79380210
Subileus	74.66	12.05	80	193804	5574	79544930
Upper respiratory tract infection	74.56	12.05	67	193817	91101	79459403
Blood pressure increased	74.21	12.05	264	193620	211096	79339408
Blood pressure systolic increased	74.09	12.05	35	193849	66951	79483553
Abdominal pain	73.88	12.05	1344	192540	388225	79162279
Malignant pleural effusion	73.55	12.05	63	193821	3317	79547187
Product prescribing error	72.76	12.05	11	193873	44802	79505702
Secondary cerebellar degeneration	72.75	12.05	19	193865	44	79550460
Hyponatraemia	72.23	12.05	705	193179	177143	79373361
Intestinal perforation	72.13	12.05	142	193742	17284	79533220
Treatment noncompliance	72.00	12.05	19	193865	52249	79498255
Hypophysitis	71.62	12.05	68	193816	4098	79546406
Tubulointerstitial nephritis	71.37	12.05	230	193654	38005	79512499
Joint stiffness	71.15	12.05	8	193876	40822	79509682
Large intestine perforation	70.62	12.05	127	193757	14440	79536064
Lactic acidosis	70.12	12.05	42	193842	70317	79480187
Epistaxis	70.06	12.05	488	193396	111027	79439477
Amnesia	69.66	12.05	33	193851	63024	79487480
Anaplastic lymphoma kinase gene mutation	69.59	12.05	22	193862	121	79550383
Neoplasm recurrence	69.07	12.05	67	193817	4147	79546357
Retinal pigment epitheliopathy	68.93	12.05	30	193854	444	79550060
Bicytopenia	68.69	12.05	70	193814	4600	79545904
Rhabdomyolysis	68.60	12.05	90	193794	103041	79447463
Alveolar soft part sarcoma	68.44	12.05	20	193864	80	79550424
Pulmonary toxicity	68.32	12.05	117	193767	12797	79537707
Fluid retention	67.73	12.05	43	193841	69766	79480738
Adverse drug reaction	67.06	12.05	39	193845	66353	79484151
Lower respiratory tract infection	66.93	12.05	133	193751	129087	79421417
Constipation	66.32	12.05	1011	192873	282039	79268465
Medication error	65.62	12.05	43	193841	68599	79481905
Paraneoplastic neurological syndrome	65.57	12.05	18	193866	54	79550450
Osteoporosis	65.08	12.05	25	193859	54087	79496417
Palmar-plantar erythrodysaesthesia syndrome	64.29	12.05	202	193682	32932	79517572
Hypoglycaemia	64.21	12.05	92	193792	101502	79449002
Localised infection	63.89	12.05	8	193876	37567	79512937
Road traffic accident	63.82	12.05	14	193870	43650	79506854
Pneumatosis intestinalis	63.33	12.05	78	193806	6319	79544185
Confusional state	63.14	12.05	483	193401	317514	79232990
Sense of oppression	62.64	12.05	42	193842	1524	79548980
Encephalopathy	61.49	12.05	325	193559	67072	79483432
Deafness	61.49	12.05	149	193735	20888	79529616
Immune-mediated myocarditis	61.27	12.05	37	193847	1116	79549388
Nephropathy toxic	60.09	12.05	145	193739	20274	79530230
Bursitis	60.06	12.05	8	193876	35836	79514668
Unevaluable event	60.02	12.05	30	193854	55555	79494949
Enterocolitis infectious	59.44	12.05	52	193832	2817	79547687
Sleep apnoea syndrome	59.12	12.05	9	193875	36469	79514035
Diabetes mellitus	59.01	12.05	62	193822	78328	79472176
Gastric disorder	58.94	12.05	10	193874	37423	79513081
Basal cell carcinoma	58.82	12.05	10	193874	37365	79513139
Lichenoid keratosis	58.20	12.05	60	193824	3997	79546507
Deep vein thrombosis	58.04	12.05	497	193387	120422	79430082
Thrombophlebitis migrans	57.64	12.05	26	193858	421	79550083
Gastrointestinal toxicity	57.48	12.05	84	193800	8025	79542479
Psychotic disorder	57.13	12.05	15	193869	41387	79509117
Tumour necrosis	57.11	12.05	43	193841	1879	79548625
Pulmonary radiation injury	56.87	12.05	16	193868	54	79550450
Joint range of motion decreased	56.80	12.05	7	193877	33275	79517229
Pericardial effusion	56.78	12.05	243	193641	45994	79504510
Cardiac disorder	56.61	12.05	46	193838	65711	79484793
Cataract	56.60	12.05	41	193843	62079	79488425
Coronary artery disease	56.12	12.05	46	193838	65428	79485076
Agitation	55.73	12.05	98	193786	99617	79450887
Blood glucose increased	55.63	12.05	123	193761	114852	79435652
Immune-mediated renal disorder	55.52	12.05	20	193864	173	79550331
Injection site haemorrhage	55.42	12.05	3	193881	27867	79522637
Cholangitis	55.19	12.05	106	193778	12670	79537834
Dermatitis	54.98	12.05	144	193740	21177	79529327
Tachycardia	54.75	12.05	667	193217	177101	79373403
Nervousness	54.71	12.05	8	193876	33407	79517097
Hepatic cytolysis	54.04	12.05	167	193717	26984	79523520
Obesity	53.97	12.05	10	193874	35115	79515389
Influenza like illness	53.65	12.05	57	193827	71650	79478854
Pulmonary vascular disorder	53.64	12.05	33	193851	1030	79549474
Superior vena cava syndrome	53.60	12.05	35	193849	1214	79549290
Product quality issue	53.59	12.05	9	193875	33931	79516573
Gait inability	53.54	12.05	39	193845	58878	79491626
Performance status decreased	53.35	12.05	70	193814	6043	79544461
Immune-mediated adrenal insuficiency	53.23	12.05	20	193864	197	79550307
Myositis	53.10	12.05	133	193751	19035	79531469
Haemolytic anaemia	52.92	12.05	127	193757	17693	79532811
Folliculitis	52.52	12.05	35	193849	55345	79495159
Venoocclusive liver disease	52.50	12.05	99	193785	11672	79538832
Joint injury	52.49	12.05	7	193877	31328	79519176
Rash maculo-papular	52.24	12.05	272	193612	55806	79494698
Aortitis	52.22	12.05	37	193847	1470	79549034
Haemolytic uraemic syndrome	51.91	12.05	59	193825	4390	79546114
Metastases to skin	51.88	12.05	39	193845	1700	79548804
Drug level increased	51.69	12.05	16	193868	39635	79510869
Sopor	51.58	12.05	9	193875	33001	79517503
Radiation skin injury	51.54	12.05	36	193848	1398	79549106
Administration site extravasation	51.29	12.05	35	193849	1308	79549196
Autoimmune haemolytic anaemia	51.18	12.05	81	193803	8299	79542205
Weight decreased	50.95	12.05	585	193299	354613	79195891
Dermatomyositis	50.93	12.05	53	193831	3570	79546934
Immune-mediated thyroiditis	50.77	12.05	21	193863	272	79550232
Adverse event	50.75	12.05	43	193841	60171	79490333
Immune-mediated hyperthyroidism	50.66	12.05	18	193866	149	79550355
Ascites	50.63	12.05	336	193548	75226	79475278
Peripheral motor neuropathy	50.49	12.05	51	193833	3316	79547188
Peripheral ischaemia	50.45	12.05	86	193798	9371	79541133
Eastern Cooperative Oncology Group performance status worsened	50.12	12.05	41	193843	2024	79548480
Portal venous gas	50.08	12.05	23	193861	389	79550115
Sciatica	49.90	12.05	10	193874	33212	79517292
Guillain-Barre syndrome	49.78	12.05	83	193801	8882	79541622
Pulmonary arteriopathy	49.59	12.05	16	193868	95	79550409
Agranulocytosis	49.51	12.05	229	193655	44801	79505703
Metastases to pleura	48.93	12.05	36	193848	1518	79548986
Head injury	48.85	12.05	15	193869	37354	79513150
Inappropriate antidiuretic hormone secretion	48.85	12.05	158	193726	26155	79524349
Device related thrombosis	48.44	12.05	45	193839	2638	79547866
Coma	48.42	12.05	108	193776	100541	79449963
Neutropenic infection	48.31	12.05	43	193841	2384	79548120
Full blood count abnormal	48.17	12.05	19	193865	40455	79510049
Nightmare	47.87	12.05	4	193880	25857	79524647
Aggression	47.26	12.05	33	193851	50925	79499579
Dyskinesia	47.10	12.05	25	193859	44748	79505756
Oesophagobronchial fistula	46.58	12.05	19	193865	237	79550267
Poisoning	46.53	12.05	4	193880	25268	79525236
Accidental overdose	46.43	12.05	19	193865	39562	79510942
Optic glioma	46.18	12.05	13	193871	44	79550460
Rhinorrhoea	46.01	12.05	71	193813	76003	79474501
Acute megakaryocytic leukaemia	45.95	12.05	13	193871	45	79550459
Tracheal fistula	45.93	12.05	17	193867	160	79550344
Acute promyelocytic leukaemia	45.74	12.05	34	193850	1457	79549047
Emotional distress	45.58	12.05	20	193864	39949	79510555
Enteritis	45.56	12.05	106	193778	14477	79536027
Type 2 diabetes mellitus	45.49	12.05	43	193841	57079	79493425
Respiratory distress	45.04	12.05	269	193615	58070	79492434
Surgery	44.96	12.05	12	193872	32754	79517750
Urticaria	44.88	12.05	265	193619	184936	79365568
Papilloedema	44.81	12.05	65	193819	6168	79544336
Irritability	44.73	12.05	22	193862	41122	79509382
Lower limb fracture	44.65	12.05	3	193881	23212	79527292
Lymphadenopathy mediastinal	44.17	12.05	54	193830	4342	79546162
Mental disorder	43.84	12.05	11	193873	31291	79519213
Tumour haemorrhage	43.42	12.05	52	193832	4092	79546412
Autoimmune colitis	43.17	12.05	34	193850	1589	79548915
Small intestinal obstruction	42.94	12.05	155	193729	27117	79523387
Oxygen saturation decreased	42.72	12.05	491	193393	128556	79421948
Withdrawal syndrome	42.67	12.05	7	193877	26847	79523657
Pain in jaw	42.65	12.05	30	193854	46121	79504383
Malignant transformation	42.43	12.05	30	193854	1188	79549316
Hepatotoxicity	42.38	12.05	241	193643	51111	79499393
Acute myelomonocytic leukaemia	42.27	12.05	19	193865	305	79550199
Incorrect route of product administration	42.23	12.05	16	193868	34913	79515591
Extremity necrosis	42.22	12.05	45	193839	3116	79547388
Cerebrovascular accident	42.13	12.05	214	193670	155078	79395426
Immune-mediated gastritis	42.06	12.05	14	193870	93	79550411
Foot fracture	41.81	12.05	3	193881	21978	79528526
Infusion related hypersensitivity reaction	41.59	12.05	20	193864	377	79550127
Oropharyngeal pain	41.49	12.05	132	193752	109221	79441283
Nephritis	41.10	12.05	51	193833	4163	79546341
Tumour associated fever	40.62	12.05	26	193858	871	79549633
Thyroiditis	40.60	12.05	53	193831	4552	79545952
Ovarian disorder	40.41	12.05	21	193863	470	79550034
Metastases to spleen	40.37	12.05	23	193861	621	79549883
Visual impairment	40.24	12.05	104	193780	92027	79458477
Terminal agitation	40.17	12.05	8	193876	0	79550504
Prescribed overdose	40.07	12.05	21	193863	37862	79512642
Neutrophil count abnormal	39.86	12.05	46	193838	3480	79547024
Pulmonary haemorrhage	39.60	12.05	101	193783	14616	79535888
Immune-mediated cholangitis	39.55	12.05	16	193868	195	79550309
Madarosis	39.40	12.05	41	193843	2761	79547743
Bronchopleural fistula	39.24	12.05	23	193861	656	79549848
Extraocular muscle disorder	39.22	12.05	18	193866	304	79550200
Stress cardiomyopathy	39.17	12.05	85	193799	11081	79539423
Procedural pain	39.04	12.05	5	193879	23079	79527425
Fanconi syndrome	38.75	12.05	41	193843	2815	79547689
BRCA2 gene mutation	38.72	12.05	13	193871	89	79550415
Throat tightness	38.47	12.05	152	193732	27755	79522749
Abortion spontaneous	38.29	12.05	12	193872	29495	79521009
International normalised ratio increased	38.27	12.05	94	193790	84627	79465877
Anaphylactoid reaction	38.19	12.05	56	193828	5366	79545138
Cancer pain	38.15	12.05	55	193829	5190	79545314
Hepatitis	38.05	12.05	249	193635	55478	79495026
Muscle spasticity	37.94	12.05	4	193880	21471	79529033
Metastases to adrenals	37.85	12.05	29	193855	1301	79549203
Hypoalbuminaemia	37.84	12.05	126	193758	21171	79529333
Haematochezia	37.47	12.05	100	193784	87545	79462959
Wrong technique in product usage process	37.42	12.05	77	193807	73798	79476706
Immune-mediated nephritis	37.40	12.05	21	193863	551	79549953
Recurrent cancer	37.15	12.05	39	193845	2654	79547850
Viral infection	37.14	12.05	30	193854	42986	79507518
Panic attack	36.98	12.05	7	193877	24209	79526295
Electrolyte imbalance	36.92	12.05	161	193723	30720	79519784
Therapy cessation	36.62	12.05	23	193861	37539	79512965
Dysstasia	36.52	12.05	11	193873	27735	79522769
Tumour hyperprogression	36.49	12.05	15	193869	191	79550313
Hallucination, visual	36.35	12.05	17	193867	32712	79517792
Balance disorder	36.35	12.05	121	193763	98736	79451768
Neck pain	36.21	12.05	81	193803	75336	79475168
Hallucination, auditory	36.19	12.05	4	193880	20689	79529815
Urogenital fistula	36.05	12.05	14	193870	152	79550352
Vision blurred	36	12.05	134	193750	105764	79444740
Extrapyramidal disorder	35.84	12.05	6	193878	22673	79527831
Myelitis transverse	35.82	12.05	33	193851	1914	79548590
B-cell lymphoma recurrent	35.69	12.05	25	193859	975	79549529
Inflammation	35.68	12.05	113	193771	93640	79456864
Metastases to kidney	35.65	12.05	20	193864	524	79549980
Rectal perforation	35.55	12.05	24	193860	881	79549623
Cyanosis	35.39	12.05	138	193746	25044	79525460
Hypersensitivity	35.36	12.05	861	193023	261378	79289126
Metastases to retroperitoneum	35.33	12.05	18	193866	386	79550118
Abdominal distension	35.30	12.05	160	193724	119490	79431014
Therapy interrupted	35.24	12.05	16	193868	31325	79519179
Product substitution issue	35.21	12.05	4	193880	20252	79530252
Swollen tongue	35.14	12.05	31	193853	42539	79507965
Night sweats	35.11	12.05	45	193839	52050	79498454
Intentional product use issue	35.10	12.05	221	193663	151891	79398613
Dermatitis acneiform	34.98	12.05	76	193808	9917	79540587
Hyperpyrexia	34.63	12.05	57	193827	6035	79544469
Paraneoplastic syndrome	34.60	12.05	25	193859	1025	79549479
Hypersomnia	34.56	12.05	7	193877	23079	79527425
Blood triglycerides increased	34.53	12.05	5	193879	21035	79529469
Musculoskeletal pain	34.48	12.05	130	193754	102224	79448280
Carbohydrate antigen 125 increased	34.44	12.05	34	193850	2150	79548354
Blood lactate dehydrogenase increased	34.44	12.05	187	193697	38983	79511521
Live birth	34.42	12.05	3	193881	18741	79531763
Mood swings	34.37	12.05	4	193880	19876	79530628
Prostate cancer	34.37	12.05	19	193865	33249	79517255
Flatulence	34.21	12.05	32	193852	42692	79507812
Ulcer	34.17	12.05	15	193869	29957	79520547
Ovarian epithelial cancer recurrent	34.17	12.05	8	193876	9	79550495
Hypervolaemia	34.15	12.05	32	193852	42658	79507846
Eosinophilia	33.97	12.05	36	193848	45309	79505195
Skin candida	33.86	12.05	33	193851	2054	79548450
Skin laceration	33.81	12.05	14	193870	28948	79521556
Diffuse large B-cell lymphoma refractory	33.80	12.05	28	193856	1407	79549097
Cytokine release syndrome	33.80	12.05	175	193709	35823	79514681
Alopecia areata	33.44	12.05	31	193853	1812	79548692
Transplant rejection	33.39	12.05	4	193880	19433	79531071
Prescribed underdose	33.29	12.05	15	193869	29499	79521005
Small cell lung cancer	33.28	12.05	38	193846	2842	79547662
Abnormal behaviour	33.23	12.05	24	193860	36397	79514107
Gallbladder disorder	33.17	12.05	4	193880	19336	79531168
Disturbance in attention	33.09	12.05	45	193839	50756	79499748
Device dislocation	32.93	12.05	11	193873	25959	79524545
Acute kidney injury	32.52	12.05	1559	192325	517845	79032659
Subdural haematoma	32.41	12.05	18	193866	31416	79519088
Hypoxia	32.03	12.05	388	193496	102855	79447649
Pericarditis malignant	31.79	12.05	10	193874	54	79550450
Product administration error	31.74	12.05	19	193865	31827	79518677
Urosepsis	31.57	12.05	138	193746	26357	79524147
Impaired work ability	31.56	12.05	5	193879	19676	79530828
Obstructive shock	31.50	12.05	11	193873	86	79550418
Lymphocyte count decreased	31.50	12.05	210	193674	47079	79503425
Hyperlipidaemia	31.47	12.05	12	193872	26081	79524423
Gastrointestinal haemorrhage	31.38	12.05	220	193664	147499	79403005
Lung adenocarcinoma	31.25	12.05	63	193821	7801	79542703
Immune-mediated encephalitis	31.23	12.05	18	193866	497	79550007
Gastrointestinal disorder	31.14	12.05	172	193712	122033	79428471
Immune-mediated adverse reaction	31.10	12.05	22	193862	872	79549632
Cholelithiasis	31.04	12.05	50	193834	52614	79497890
Leukoencephalopathy	30.89	12.05	63	193821	7866	79542638
Infected lymphocele	30.85	12.05	14	193870	230	79550274
Cholangitis sclerosing	30.82	12.05	35	193849	2602	79547902
Disability	30.74	12.05	3	193881	17117	79533387
Gastroenteritis viral	30.65	12.05	11	193873	24820	79525684
Immune thrombocytopenia	30.45	12.05	104	193780	17701	79532803
Tendonitis	30.38	12.05	10	193874	23820	79526684
Joint dislocation	30.33	12.05	3	193881	16936	79533568
Limb injury	30.31	12.05	17	193867	29511	79520993
Fear	30.27	12.05	8	193876	21978	79528526
Upper limb fracture	30.13	12.05	4	193880	17963	79532541
Respiratory tract congestion	29.98	12.05	6	193878	19948	79530556
Ill-defined disorder	29.82	12.05	73	193811	65802	79484702
Tumour embolism	29.77	12.05	13	193871	194	79550310
Extravasation	29.76	12.05	41	193843	3709	79546795
Respiratory depression	29.70	12.05	15	193869	27615	79522889
Breast cancer metastatic	29.63	12.05	65	193819	8537	79541967
Metastases to spine	29.51	12.05	44	193840	4280	79546224
Systemic infection	29.50	12.05	70	193814	9682	79540822
Venous thrombosis	29.47	12.05	58	193826	7058	79543446
Cerebral infarction	29.33	12.05	201	193683	45475	79505029
Hiccups	29.26	12.05	71	193813	9960	79540544
Colitis ischaemic	29.21	12.05	93	193791	15266	79535238
Acoustic stimulation tests abnormal	29.14	12.05	8	193876	24	79550480
Delusion	28.95	12.05	7	193877	20416	79530088
Gastrointestinal necrosis	28.89	12.05	50	193834	5515	79544989
Paranoia	28.87	12.05	6	193878	19426	79531078
Acne	28.87	12.05	15	193869	27175	79523329
Device issue	28.71	12.05	15	193869	27093	79523411
Secondary adrenocortical insufficiency	28.64	12.05	36	193848	2978	79547526
Oesophagopleural fistula	28.55	12.05	9	193875	49	79550455
Non-small cell lung cancer recurrent	28.53	12.05	11	193873	117	79550387
Empyema	28.45	12.05	43	193841	4233	79546271
Hip fracture	28.42	12.05	20	193864	30741	79519763
Endocarditis noninfective	28.41	12.05	13	193871	218	79550286
Transient ischaemic attack	28.35	12.05	53	193831	52642	79497862
Capillary leak syndrome	28.31	12.05	41	193843	3884	79546620
Hypoaesthesia	28.24	12.05	289	193595	179063	79371441
Retinopathy proliferative	28.12	12.05	11	193873	122	79550382
Laryngeal cancer stage III	27.99	12.05	8	193876	29	79550475
Haemorrhage	27.99	12.05	120	193764	90998	79459506
Joint effusion	27.95	12.05	5	193879	18009	79532495
Injection site rash	27.82	12.05	5	193879	17949	79532555
Spinal stenosis	27.75	12.05	3	193881	15788	79534716
Cachexia	27.71	12.05	74	193810	11009	79539495
Dyspepsia	27.68	12.05	153	193731	108534	79441970
Histiocytic necrotising lymphadenitis	27.68	12.05	9	193875	55	79550449
Anastomotic leak	27.66	12.05	22	193862	1043	79549461
Pelvic abscess	27.66	12.05	30	193854	2119	79548385
Palpitations	27.66	12.05	187	193697	126423	79424081
Sinus disorder	27.65	12.05	10	193874	22454	79528050
Adrenal disorder	27.64	12.05	30	193854	2121	79548383
Autoimmune nephritis	27.61	12.05	19	193865	720	79549784
Musculoskeletal disorder	27.34	12.05	9	193875	21439	79529065
Obstructive airways disorder	27.08	12.05	22	193862	31437	79519067
Chest discomfort	27.06	12.05	479	193405	137565	79412939
Retroperitoneal lymphadenopathy	27.04	12.05	22	193862	1078	79549426
Eye pain	26.87	12.05	31	193853	37547	79512957
Seasonal allergy	26.69	12.05	4	193880	16402	79534102
Onycholysis	26.67	12.05	29	193855	2054	79548450
Pseudocirrhosis	26.63	12.05	18	193866	662	79549842
Encephalitis enteroviral	26.63	12.05	11	193873	142	79550362
Iris neovascularisation	26.51	12.05	9	193875	64	79550440
Poor quality sleep	26.50	12.05	11	193873	22711	79527793
Femur fracture	26.45	12.05	33	193851	38619	79511885
Kidney infection	26.43	12.05	10	193874	21841	79528663
Hypophagia	26.43	12.05	195	193689	45172	79505332
Laryngospasm	26.32	12.05	40	193844	3957	79546547
Hepatic steatosis	26.06	12.05	32	193852	37706	79512798
Iron deficiency anaemia	26.04	12.05	15	193869	25657	79524847
Fatigue	26.03	12.05	1928	191956	927799	78622705
Iris atrophy	26.02	12.05	11	193873	151	79550353
Acute erythroid leukaemia	25.98	12.05	13	193871	268	79550236
Embolism venous	25.92	12.05	41	193843	4198	79546306
Non-small cell lung cancer metastatic	25.88	12.05	21	193863	1025	79549479
Dry mouth	25.78	12.05	118	193766	87901	79462603
Lung cancer metastatic	25.76	12.05	38	193846	3661	79546843
Metastases to bladder	25.72	12.05	13	193871	274	79550230
Ovarian cancer metastatic	25.67	12.05	17	193867	604	79549900
Platelet count abnormal	25.65	12.05	44	193840	4818	79545686
Vitreous haemorrhage	25.65	12.05	38	193846	3675	79546829
Injection site warmth	25.55	12.05	3	193881	14804	79535700
Crying	25.54	12.05	12	193872	23031	79527473
Faeces discoloured	25.54	12.05	20	193864	29107	79521397
Blood urine present	25.34	12.05	10	193874	21287	79529217
Underdose	25.19	12.05	26	193858	33125	79517379
Hepatocellular injury	25.17	12.05	200	193684	47393	79503111
Fulminant type 1 diabetes mellitus	25.10	12.05	24	193860	1459	79549045
Endometrial cancer recurrent	25.07	12.05	6	193878	8	79550496
Liver function test abnormal	25.04	12.05	77	193807	64398	79486106
Oligoastrocytoma	24.79	12.05	7	193877	24	79550480
Haemophagocytic lymphohistiocytosis	24.71	12.05	112	193772	21725	79528779
Impaired quality of life	24.61	12.05	3	193881	14383	79536121
Ejection fraction decreased	24.53	12.05	156	193728	34421	79516083
Cardiac arrest	24.41	12.05	284	193600	171812	79378692
Radiation mucositis	24.36	12.05	12	193872	239	79550265
Sinus congestion	24.24	12.05	9	193875	19887	79530617
Burning sensation	24.23	12.05	68	193816	58564	79491940
Depressed level of consciousness	24.10	12.05	137	193747	96515	79453989
Breast cancer	24.01	12.05	28	193856	33753	79516751
Glomerular vascular disorder	24.01	12.05	11	193873	185	79550319
Hip arthroplasty	23.98	12.05	31	193853	35725	79514779
Oral herpes	23.88	12.05	19	193865	27435	79523069
Frequent bowel movements	23.80	12.05	22	193862	29517	79520987
Pulmonary oedema	23.71	12.05	122	193762	88132	79462372
Oropharyngeal squamous cell carcinoma	23.70	12.05	12	193872	254	79550250
Hepatic cirrhosis	23.68	12.05	30	193854	34876	79515628
Swelling face	23.62	12.05	91	193793	71121	79479383
Arteriosclerosis coronary artery	23.56	12.05	7	193877	17809	79532695
Lymphadenopathy	23.54	12.05	215	193669	53032	79497472
Carpal tunnel syndrome	23.52	12.05	9	193875	19519	79530985
Rib fracture	23.49	12.05	20	193864	27927	79522577
Diabetes mellitus inadequate control	23.46	12.05	15	193869	24249	79526255
Pancreatic toxicity	23.43	12.05	8	193876	58	79550446
Ameloblastoma	23.40	12.05	9	193875	95	79550409
Eye disorder	23.29	12.05	14	193870	23398	79527106
Cardiac murmur	23.27	12.05	5	193879	15819	79534685
Splenic artery thrombosis	23.20	12.05	8	193876	60	79550444
Myeloid leukaemia	23.12	12.05	17	193867	716	79549788
Hypertensive crisis	23.11	12.05	106	193778	20664	79529840
Blood glucose decreased	23.02	12.05	18	193866	26216	79524288
Myoclonus	23.00	12.05	20	193864	27640	79522864
Cellulitis gangrenous	22.99	12.05	12	193872	271	79550233
Glycosylated haemoglobin increased	22.99	12.05	9	193875	19251	79531253
Metastases to muscle	22.95	12.05	13	193871	347	79550157
Immune-mediated arthritis	22.89	12.05	11	193873	207	79550297
Pulmonary cavitation	22.87	12.05	24	193860	1632	79548872
Radiation dysphagia	22.77	12.05	5	193879	3	79550501
Lung abscess	22.74	12.05	38	193846	4074	79546430
Brachydactyly	22.70	12.05	7	193877	35	79550469
Cystoid macular oedema	22.67	12.05	26	193858	1954	79548550
Blood pressure diastolic increased	22.64	12.05	4	193880	14538	79535966
Blood pressure diastolic decreased	22.62	12.05	24	193860	30192	79520312
Autoimmune dermatitis	22.56	12.05	10	193874	155	79550349
Head discomfort	22.56	12.05	4	193880	14498	79536006
Skin reaction	22.54	12.05	88	193796	15980	79534524
Oesophageal stenosis	22.45	12.05	39	193845	4315	79546189
Lymphopenia	22.38	12.05	139	193745	30418	79520086
Ureteric fistula	22.37	12.05	6	193878	16	79550488
Drug level decreased	22.34	12.05	4	193880	14398	79536106
Cholestasis	22.33	12.05	209	193675	51900	79498604
Pseudocellulitis	22.33	12.05	8	193876	68	79550436
Bone density decreased	22.31	12.05	3	193881	13344	79537160
Oesophageal fistula	22.25	12.05	14	193870	455	79550049
Dysaesthesia	22.23	12.05	46	193838	5802	79544702
Product dispensing error	22.12	12.05	3	193881	13260	79537244
Osteosarcoma	22.05	12.05	13	193871	375	79550129
Hernia	22.03	12.05	7	193877	17052	79533452
Faecaloma	21.97	12.05	70	193814	11494	79539010
Transaminases increased	21.91	12.05	207	193677	51536	79498968
Carbamoyl phosphate synthetase deficiency	21.86	12.05	6	193878	18	79550486
Erythema multiforme	21.85	12.05	93	193791	17558	79532946
Ankle fracture	21.84	12.05	7	193877	16962	79533542
Myelitis	21.83	12.05	28	193856	2363	79548141
Mechanical ileus	21.79	12.05	18	193866	901	79549603
TP53 gene mutation	21.78	12.05	7	193877	41	79550463
Bronchostenosis	21.74	12.05	16	193868	675	79549829
Metabolic acidosis	21.66	12.05	115	193769	82414	79468090
Noninfectious myelitis	21.61	12.05	6	193878	19	79550485
Kounis syndrome	21.61	12.05	38	193846	4244	79546260
Rash pruritic	21.59	12.05	95	193789	71534	79478970
Shock	21.41	12.05	180	193704	43368	79507136
Rhabdomyosarcoma recurrent	21.39	12.05	9	193875	122	79550382
Hair texture abnormal	21.36	12.05	34	193850	3500	79547004
Cardiac dysfunction	21.34	12.05	37	193847	4087	79546417
Small cell carcinoma	21.33	12.05	12	193872	316	79550188
Sinus bradycardia	21.31	12.05	18	193866	25229	79525275
Miosis	21.26	12.05	6	193878	15783	79534721
Intervertebral disc degeneration	21.25	12.05	6	193878	15779	79534725
Subacute cutaneous lupus erythematosus	21.17	12.05	34	193850	3527	79546977
Delayed puberty	21.11	12.05	10	193874	182	79550322
Eye irritation	21.09	12.05	12	193872	20669	79529835
Muscle rigidity	21.06	12.05	11	193873	19871	79530633
Myasthenic syndrome	21.03	12.05	17	193867	825	79549679
Hypokinesia	21.01	12.05	10	193874	19050	79531454
Dystonia	21.00	12.05	13	193871	21386	79529118
Renal tubular necrosis	20.98	12.05	118	193766	24921	79525583
Arterioenteric fistula	20.94	12.05	6	193878	22	79550482
Eye pruritus	20.89	12.05	12	193872	20558	79529946
Acquired tracheo-oesophageal fistula	20.88	12.05	9	193875	130	79550374
Photophobia	20.81	12.05	12	193872	20516	79529988
Eye excision	20.76	12.05	8	193876	85	79550419
Scleroderma-like reaction	20.75	12.05	9	193875	132	79550372
Hair colour changes	20.64	12.05	37	193847	4195	79546309
Periarticular thenar erythema with onycholysis	20.48	12.05	7	193877	51	79550453
Orthostatic hypotension	20.47	12.05	69	193815	56095	79494409
Pleurocutaneous fistula	20.36	12.05	7	193877	52	79550452
Blood creatine phosphokinase increased	20.32	12.05	87	193797	66003	79484501
Mood altered	20.24	12.05	9	193875	17838	79532666
Oedema peripheral	20.22	12.05	463	193421	251825	79298679
Depressed mood	20.20	12.05	56	193828	48424	79502080
Double hit lymphoma	20.15	12.05	6	193878	26	79550478
Heat cramps	20.09	12.05	4	193880	0	79550504
Bladder perforation	20.08	12.05	12	193872	355	79550149
Toxic skin eruption	19.98	12.05	107	193777	22186	79528318
Ovarian cancer	19.97	12.05	35	193849	3899	79546605
Scintillating scotoma	19.95	12.05	10	193874	207	79550297
Metaplasia	19.94	12.05	14	193870	548	79549956
Breast cancer recurrent	19.90	12.05	30	193854	2947	79547557
Optic atrophy	19.83	12.05	24	193860	1909	79548595
Thinking abnormal	19.68	12.05	4	193880	13157	79537347
Lipoprotein increased	19.64	12.05	5	193879	10	79550494
Monocyte count decreased	19.63	12.05	31	193853	3170	79547334
Encephalitis autoimmune	19.60	12.05	26	193858	2268	79548236
Pelvic infection	19.58	12.05	12	193872	372	79550132
Left ventricular dysfunction	19.49	12.05	96	193788	19265	79531239
Blast cells present	19.45	12.05	17	193867	920	79549584
Hyperkalaemia	19.40	12.05	181	193703	114217	79436287
Chronic sinusitis	19.40	12.05	4	193880	13022	79537482
Arteriosclerotic retinopathy	19.29	12.05	6	193878	31	79550473
BRCA1 gene mutation	19.29	12.05	6	193878	31	79550473
Gastropleural fistula	19.29	12.05	7	193877	62	79550442
Gout	19.27	12.05	19	193865	24730	79525774
Haemoglobin	19.25	12.05	8	193876	105	79550399
Cellulitis	19.17	12.05	171	193713	108889	79441615
Lupus-like syndrome	19.15	12.05	5	193879	13852	79536652
Type 1 diabetes mellitus	19.15	12.05	48	193836	6871	79543633
Chromosomal mutation	19.13	12.05	6	193878	32	79550472
Laryngeal discomfort	19.12	12.05	14	193870	586	79549918
Fracture	19.07	12.05	15	193869	21786	79528718
Gliosis	19.07	12.05	13	193871	485	79550019
Dysarthria	19.01	12.05	92	193792	67530	79482974
Basal cell naevus syndrome	18.98	12.05	6	193878	33	79550471
Amoebic colitis	18.98	12.05	8	193876	109	79550395
Bladder cancer	18.97	12.05	12	193872	19514	79530990
Peritonitis	18.97	12.05	125	193759	27911	79522593
Metastases to the mediastinum	18.91	12.05	14	193870	596	79549908
Aplastic anaemia	18.91	12.05	90	193794	17815	79532689
Pancreatitis	18.87	12.05	94	193790	68481	79482023
Laryngeal necrosis	18.83	12.05	6	193878	34	79550470
Tumour cavitation	18.83	12.05	6	193878	34	79550470
Pollakiuria	18.81	12.05	39	193845	37278	79513226
Lip swelling	18.78	12.05	45	193839	40866	79509638
Mixed deafness	18.74	12.05	5	193879	13	79550491
Infantile vomiting	18.74	12.05	5	193879	13	79550491
Haemoglobin decreased	18.69	12.05	688	193196	221431	79329073
Glioma	18.67	12.05	14	193870	608	79549896
Spinal cord infarction	18.65	12.05	14	193870	609	79549895
Hepatitis B reactivation	18.64	12.05	44	193840	6064	79544440
Ear pain	18.63	12.05	32	193852	32837	79517667
Laryngeal pain	18.62	12.05	44	193840	6070	79544434
Limb discomfort	18.61	12.05	32	193852	32818	79517686
Intervertebral disc protrusion	18.55	12.05	18	193866	23603	79526901
Coronary artery occlusion	18.54	12.05	7	193877	15308	79535196
Medulloblastoma recurrent	18.53	12.05	8	193876	116	79550388
Carcinoid crisis	18.49	12.05	13	193871	510	79549994
Lung squamous cell carcinoma metastatic	18.45	12.05	7	193877	71	79550433
Emotional disorder	18.40	12.05	6	193878	14381	79536123
Angiodermatitis	18.36	12.05	7	193877	72	79550432
Nail disorder	18.35	12.05	67	193817	11785	79538719
Ligament sprain	18.34	12.05	5	193879	13459	79537045
Pulmonary alveolar haemorrhage	17.94	12.05	65	193819	11392	79539112
Akathisia	17.92	12.05	5	193879	13254	79537250
Squamous cell carcinoma of lung	17.91	12.05	25	193859	2289	79548215
Metastases to abdominal wall	17.88	12.05	9	193875	188	79550316
Cytokine storm	17.84	12.05	17	193867	1029	79549475
Facet joint syndrome	17.84	12.05	3	193881	11299	79539205
Malignant ascites	17.77	12.05	18	193866	1174	79549330
Barotrauma	17.75	12.05	9	193875	191	79550313
Tooth infection	17.72	12.05	12	193872	18820	79531684
Renal cancer	17.70	12.05	4	193880	12222	79538282
Eye swelling	17.69	12.05	23	193861	26445	79524059
Bronchiectasis	17.65	12.05	17	193867	22369	79528135
Heavy menstrual bleeding	17.65	12.05	6	193878	14005	79536499
Duodenal perforation	17.62	12.05	24	193860	2148	79548356
Stem cell transplant	17.58	12.05	32	193852	3672	79546832
Hyperaemia	17.55	12.05	29	193855	3081	79547423
Odynophagia	17.51	12.05	64	193820	11263	79539241
Skin ulcer	17.45	12.05	70	193814	54080	79496424
Venoocclusive disease	17.42	12.05	36	193848	4537	79545967
Thirst	17.34	12.05	12	193872	18607	79531897
Tooth disorder	17.33	12.05	23	193861	26210	79524294
Oral papule	17.32	12.05	4	193880	4	79550500
Febrile infection	17.29	12.05	30	193854	3316	79547188
Blood loss anaemia	17.29	12.05	8	193876	15490	79535014
Paraneoplastic rash	17.18	12.05	7	193877	87	79550417
Vaginal fistula	17.16	12.05	10	193874	282	79550222
Nervous system disorder	17.13	12.05	118	193766	26738	79523766
Jaw operation	17.12	12.05	15	193869	814	79549690
Autoimmune cholangitis	17.11	12.05	5	193879	20	79550484
Therapeutic response unexpected	17.10	12.05	14	193870	19932	79530572
Bone pain	17.07	12.05	209	193675	55533	79494971
BRAF V600E mutation positive	17.06	12.05	6	193878	48	79550456
COVID-19	17.03	12.05	275	193609	157399	79393105
Engraftment syndrome	16.98	12.05	19	193865	1390	79549114
Dementia	16.93	12.05	21	193863	24638	79525866
Encephalitis	16.92	12.05	76	193808	14684	79535820
Thrombocytopenia neonatal	16.92	12.05	5	193879	21	79550483
Musculoskeletal discomfort	16.91	12.05	14	193870	19821	79530683
Radiation injury	16.91	12.05	15	193869	828	79549676
Choroidal dystrophy	16.85	12.05	6	193878	50	79550454
Pancreatic carcinoma	16.78	12.05	6	193878	13571	79536933
Radiotherapy	16.78	12.05	13	193871	593	79549911
Herpes zoster	16.78	12.05	145	193739	92938	79457566
Gamma-glutamyltransferase increased	16.74	12.05	205	193679	54475	79496029
Mania	16.70	12.05	12	193872	18248	79532256
Angina pectoris	16.59	12.05	67	193817	51665	79498839
Pharyngitis streptococcal	16.57	12.05	3	193881	10711	79539793
Immune-mediated neurological disorder	16.55	12.05	5	193879	23	79550481
Retinopathy	16.46	12.05	32	193852	3859	79546645
Gene mutation	16.45	12.05	26	193858	2660	79547844
Vascular access site swelling	16.44	12.05	4	193880	6	79550498
Aortic wall hypertrophy	16.44	12.05	4	193880	6	79550498
Bone marrow infiltration	16.43	12.05	14	193870	732	79549772
Urinary tract obstruction	16.40	12.05	36	193848	4729	79545775
Tenderness	16.37	12.05	20	193864	23622	79526882
Respiratory arrest	16.35	12.05	78	193806	57472	79493032
Blood creatinine increased	16.29	12.05	493	193391	154564	79395940
Lymph node abscess	16.26	12.05	6	193878	56	79550448
Cold sweat	16.25	12.05	89	193795	18610	79531894
Granulocyte count decreased	16.24	12.05	21	193863	1787	79548717
Pulmonary hypertension	16.23	12.05	61	193823	48019	79502485
Ocular vascular disorder	16.19	12.05	12	193872	512	79549992
Administration related reaction	16.17	12.05	9	193875	232	79550272
Rotator cuff syndrome	16.15	12.05	7	193877	14088	79536416
Blood potassium increased	16.14	12.05	29	193855	29246	79521258
Right ventricular failure	16.14	12.05	20	193864	23477	79527027
Infectious pleural effusion	16.09	12.05	31	193853	3713	79546791
Muscle twitching	16.06	12.05	22	193862	24742	79525762
White blood cell count abnormal	16.05	12.05	40	193844	5705	79544799
Increased tendency to bruise	16.03	12.05	3	193881	10461	79540043
Osteomyelitis	16.02	12.05	35	193849	32830	79517674
Refractory anaemia with an excess of blasts	15.98	12.05	15	193869	891	79549613
Eosinophil count increased	15.96	12.05	11	193873	17094	79533410
Device related infection	15.94	12.05	140	193744	34154	79516350
Growth hormone deficiency	15.91	12.05	11	193873	420	79550084
Tenosynovitis	15.90	12.05	9	193875	15545	79534959
Hypercreatininaemia	15.88	12.05	16	193868	1037	79549467
Cancer fatigue	15.85	12.05	8	193876	168	79550336
Hiatus hernia	15.85	12.05	20	193864	23292	79527212
Embolism arterial	15.83	12.05	19	193865	1499	79549005
Chronic coronary syndrome	15.82	12.05	7	193877	108	79550396
Pelvic fracture	15.77	12.05	5	193879	12199	79538305
Neuroendocrine tumour of the lung metastatic	15.76	12.05	7	193877	109	79550395
Intestinal obstruction	15.74	12.05	167	193717	42853	79507651
Metastases to abdominal cavity	15.73	12.05	13	193871	651	79549853
Venous thrombosis limb	15.72	12.05	34	193850	4423	79546081
Cardiac tamponade	15.70	12.05	54	193830	9222	79541282
Bacterial tracheitis	15.63	12.05	6	193878	63	79550441
Glaucoma	15.59	12.05	15	193869	19746	79530758
Accidental exposure to product	15.56	12.05	33	193851	31289	79519215
Cardiomegaly	15.55	12.05	25	193859	26327	79524177
Hypotensive crisis	15.54	12.05	7	193877	113	79550391
Nephrotic syndrome	15.51	12.05	61	193823	11113	79539391
Right ventricular ejection fraction decreased	15.46	12.05	6	193878	65	79550439
Aortic dissection rupture	15.38	12.05	6	193878	66	79550438
Emphysematous cystitis	15.36	12.05	10	193874	345	79550159
Increased appetite	15.31	12.05	5	193879	11973	79538531
Paraesthesia	15.28	12.05	548	193336	175775	79374729
Abdominal abscess	15.28	12.05	45	193839	7082	79543422
Retinal toxicity	15.27	12.05	18	193866	1393	79549111
Metastases to bone marrow	15.25	12.05	14	193870	808	79549696
Hyperbilirubinaemia	15.21	12.05	107	193777	24411	79526093
Retinal degeneration	15.13	12.05	17	193867	1249	79549255
Failure to thrive	15.12	12.05	63	193821	11781	79538723
Metastases to pancreas	15.11	12.05	12	193872	568	79549936
Radiation neuropathy	15.10	12.05	4	193880	10	79550494
Pathogen resistance	15.09	12.05	8	193876	14334	79536170
Spinal fracture	15.08	12.05	13	193871	18041	79532463
Metastatic choriocarcinoma	15.07	12.05	3	193881	0	79550504
Haemorrhoids	15.06	12.05	30	193854	29098	79521406
Abdominal compartment syndrome	15.05	12.05	19	193865	1578	79548926
Body temperature decreased	15.04	12.05	35	193849	32110	79518394
Fanconi syndrome acquired	15.04	12.05	25	193859	2669	79547835
Endocrine disorder	14.98	12.05	14	193870	827	79549677
Hypotension	14.98	12.05	1254	192630	439063	79111441
Ovarian cyst	14.96	12.05	6	193878	12649	79537855
Skin cancer	14.95	12.05	9	193875	15031	79535473
Autoimmune hypothyroidism	14.95	12.05	9	193875	270	79550234
Neutrophil percentage decreased	14.87	12.05	14	193870	835	79549669
Adenocarcinoma of appendix	14.84	12.05	6	193878	73	79550431
Gastritis bacterial	14.84	12.05	10	193874	366	79550138
Vaginal cuff dehiscence	14.83	12.05	4	193880	11	79550493
Aortic injury	14.83	12.05	4	193880	11	79550493
Lung infiltration	14.81	12.05	101	193783	22811	79527693
Pulmonary congestion	14.81	12.05	27	193857	27073	79523431
VIth nerve paralysis	14.80	12.05	19	193865	1605	79548899
No adverse event	14.74	12.05	44	193840	37148	79513356
Fungal infection	14.73	12.05	52	193832	41696	79508808
PIK3CA-activated mutation	14.69	12.05	12	193872	591	79549913
Metastases to breast	14.65	12.05	9	193875	280	79550224
Atrioventricular block first degree	14.64	12.05	6	193878	12485	79538019
Aorto-oesophageal fistula	14.63	12.05	6	193878	76	79550428
Eyelid oedema	14.60	12.05	69	193815	13618	79536886
Peritoneal disorder	14.59	12.05	13	193871	722	79549782
Benign prostatic hyperplasia	14.58	12.05	5	193879	11607	79538897
Adenosquamous cell lung cancer stage IV	14.57	12.05	4	193880	12	79550492
Food protein-induced enterocolitis syndrome	14.56	12.05	5	193879	37	79550467
Uterine adhesions	14.44	12.05	5	193879	38	79550466
Pyopneumothorax	14.42	12.05	6	193878	79	79550425
Tongue disorder	14.41	12.05	8	193876	13967	79536537
Laboratory test abnormal	14.40	12.05	29	193855	28019	79522485
Pharyngitis	14.39	12.05	20	193864	22355	79528149
Chills	14.38	12.05	500	193384	159734	79390770
Facial pain	14.37	12.05	6	193878	12344	79538160
Neuroblastoma recurrent	14.35	12.05	8	193876	207	79550297
Cytotoxic oedema	14.35	12.05	10	193874	387	79550117
Endometrial cancer metastatic	14.33	12.05	5	193879	39	79550465
Sneezing	14.33	12.05	16	193868	19667	79530837
Neutrophil count	14.31	12.05	8	193876	208	79550296
Upper gastrointestinal haemorrhage	14.30	12.05	52	193832	41328	79509176
Lymphocele	14.28	12.05	19	193865	1662	79548842
Pneumonia adenoviral	14.21	12.05	11	193873	501	79550003
Abnormal dreams	14.18	12.05	5	193879	11407	79539097
Cyst	14.16	12.05	8	193876	13832	79536672
Post-acute COVID-19 syndrome	14.16	12.05	11	193873	504	79550000
Arrhythmia	14.14	12.05	89	193795	61183	79489321
Meningitis tuberculous	14.09	12.05	16	193868	1189	79549315
Laryngitis	14.08	12.05	11	193873	16028	79534476
Renal impairment	14.07	12.05	492	193392	157291	79393213
Systemic candida	14.05	12.05	42	193842	6664	79543840
Myalgia	13.95	12.05	344	193540	185297	79365207
Thrombocytosis	13.89	12.05	49	193835	8477	79542027
Scar	13.88	12.05	10	193874	15186	79535318
Peripheral venous disease	13.85	12.05	11	193873	15898	79534606
Autoimmune disorder	13.83	12.05	12	193872	16600	79533904
Restlessness	13.81	12.05	62	193822	46430	79504074
Opsoclonus myoclonus	13.78	12.05	8	193876	224	79550280
Meningitis herpes	13.75	12.05	8	193876	225	79550279
Bacteraemia	13.74	12.05	131	193753	32693	79517811
Vena cava thrombosis	13.73	12.05	25	193859	2870	79547634
Acute monocytic leukaemia	13.71	12.05	11	193873	528	79549976
Skin hyperpigmentation	13.69	12.05	44	193840	7259	79543245
Lymphangitis	13.67	12.05	17	193867	1391	79549113
Neoplasm	13.67	12.05	51	193833	9065	79541439
Mediastinum neoplasm	13.65	12.05	6	193878	91	79550413
Skin haemorrhage	13.65	12.05	6	193878	11975	79538529
Kidney transplant rejection	13.60	12.05	4	193880	10242	79540262
Clostridium difficile colitis	13.59	12.05	129	193755	32154	79518350
Ovarian failure	13.50	12.05	12	193872	664	79549840
Metastases to vagina	13.50	12.05	4	193880	17	79550487
Nerve compression	13.42	12.05	3	193881	9236	79541268
Chondritis	13.42	12.05	7	193877	158	79550346
Anal sphincter atony	13.36	12.05	9	193875	329	79550175
Gastric perforation	13.33	12.05	30	193854	4007	79546497
Leukaemia	13.27	12.05	38	193846	5887	79544617
Pneumothorax spontaneous	13.23	12.05	17	193867	1437	79549067
Adenomatous polyposis coli	13.23	12.05	8	193876	242	79550262
Abdominal pain upper	13.19	12.05	429	193455	223390	79327114
Spinal osteoarthritis	13.18	12.05	13	193871	16914	79533590
Purpura	13.17	12.05	87	193797	19440	79531064
Epstein Barr virus positive mucocutaneous ulcer	13.17	12.05	13	193871	822	79549682
Eyelid rash	13.14	12.05	7	193877	165	79550339
Chromosome analysis abnormal	13.14	12.05	8	193876	245	79550259
Renal failure	13.13	12.05	606	193278	200362	79350142
Jugular vein thrombosis	13.11	12.05	32	193852	4506	79545998
Upper-airway cough syndrome	13.10	12.05	6	193878	11687	79538817
Escherichia sepsis	13.09	12.05	48	193836	8460	79542044
Autoimmune hepatitis	13.01	12.05	60	193824	11723	79538781
Hypophosphataemia	13.00	12.05	88	193796	19825	79530679
Vaginal perforation	12.99	12.05	3	193881	3	79550501
Peritoneal lesion	12.99	12.05	3	193881	3	79550501
Cytomegalovirus enterocolitis	12.99	12.05	18	193866	1637	79548867
Dyslipidaemia	12.98	12.05	6	193878	11627	79538877
Acquired amegakaryocytic thrombocytopenia	12.97	12.05	4	193880	20	79550484
Malignant peritoneal neoplasm	12.94	12.05	12	193872	702	79549802
Colitis microscopic	12.90	12.05	5	193879	10763	79539741
Type 1 lepra reaction	12.90	12.05	5	193879	54	79550450
Vasogenic cerebral oedema	12.88	12.05	17	193867	1476	79549028
Gastric neoplasm	12.83	12.05	9	193875	352	79550152
Laryngeal leukoplakia	12.74	12.05	5	193879	56	79550448
Pericardial effusion malignant	12.70	12.05	7	193877	177	79550327
Cystitis haemorrhagic	12.67	12.05	50	193834	9122	79541382
Autoimmune neutropenia	12.67	12.05	11	193873	590	79549914
Respiratory fatigue	12.66	12.05	8	193876	262	79550242
Ileal perforation	12.66	12.05	14	193870	1011	79549493
Breast cancer female	12.65	12.05	6	193878	11455	79539049
Eye haemorrhage	12.60	12.05	4	193880	9753	79540751
Speech disorder	12.60	12.05	79	193805	54366	79496138
Flagellate dermatitis	12.58	12.05	8	193876	265	79550239
Q fever	12.58	12.05	8	193876	265	79550239
Miller Fisher syndrome	12.55	12.05	8	193876	266	79550238
Vascular purpura	12.53	12.05	25	193859	3073	79547431
Systemic scleroderma	12.51	12.05	15	193869	1182	79549322
Blood glucose abnormal	12.51	12.05	5	193879	10561	79539943
CSF white blood cell count decreased	12.51	12.05	4	193880	23	79550481
Immune-mediated cytopenia	12.51	12.05	5	193879	59	79550445
Temperature intolerance	12.50	12.05	4	193880	9701	79540803
Necrotising colitis	12.49	12.05	14	193870	1026	79549478
Infected neoplasm	12.48	12.05	9	193875	368	79550136
Dysentery	12.46	12.05	15	193869	1187	79549317
Injection site extravasation	12.43	12.05	4	193880	9665	79540839
Choriocarcinoma	12.36	12.05	5	193879	61	79550443
Bedridden	12.33	12.05	7	193877	12072	79538432
Secretion discharge	12.32	12.05	11	193873	15011	79535493
Rhegmatogenous retinal detachment	12.29	12.05	7	193877	189	79550315
Intestinal metastasis	12.29	12.05	9	193875	377	79550127
Vitamin D deficiency	12.27	12.05	10	193874	14269	79536235
Affect lability	12.27	12.05	6	193878	11253	79539251
Lung adenocarcinoma recurrent	12.22	12.05	4	193880	25	79550479
Adenovirus reactivation	12.22	12.05	9	193875	380	79550124
Malaise	12.22	12.05	1025	192859	488844	79061660
Tumour marker increased	12.21	12.05	30	193854	4242	79546262
Ectopic ACTH syndrome	12.16	12.05	7	193877	193	79550311
Left ventricular hypertrophy	12.14	12.05	6	193878	11185	79539319
Large intestine polyp	12.09	12.05	8	193876	12700	79537804
Renal tubular dysfunction	12.08	12.05	12	193872	765	79549739

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L01XA02	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Platinum compounds
FDA EXT	N0000175073	Platinum-containing Compounds
FDA EPC	N0000175413	Platinum-based Drug
CHEBI has role	CHEBI:25435	mutagens
CHEBI has role	CHEBI:35610	antineoplastic agents
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D003432	Cross-Linking Reagents
MeSH PA	D007202	Indicators and Reagents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Breast cancer	indication	254837009	DOID:1612
Malignant tumor of ovary	indication	363443007	DOID:2394
Ewing's sarcoma	off-label use	76909002	DOID:3369
Acute myeloid leukemia, disease	off-label use	91861009
Small cell carcinoma of lung	off-label use	254632001	DOID:5409
Non-small cell lung cancer	off-label use	254637007	DOID:3908
Endometrial carcinoma	off-label use	254878006	DOID:2871
Malignant tumor of head and/or neck	off-label use	255056009
Seminoma of testis	off-label use	255107005
Malignant tumor of cervix	off-label use	363354003	DOID:4362
Malignant tumor of testis	off-label use	363449006	DOID:2998
Malignant tumor of urinary bladder	off-label use	399326009	DOID:11054
Metastatic Breast Carcinoma	off-label use
Refractory Osteosarcoma	off-label use
Neuroendocrine Prostate Carcinoma	off-label use
Progressive Diffuse Large B-Cell Lymphoma	off-label use
Acute vomiting	contraindication	23971007
Acute infectious disease	contraindication	63171007
Blood coagulation disorder	contraindication	64779008	DOID:1247
Leukopenia	contraindication	84828003	DOID:615
Kidney disease	contraindication	90708001	DOID:557
Hearing disorder	contraindication	128540005
Liver function tests abnormal	contraindication	166603001
Disease of liver	contraindication	235856003	DOID:409
Anemia	contraindication	271737000	DOID:2355
Pregnancy, function	contraindication	289908002
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Peripheral nerve disease	contraindication	302226006
Neutropenic disorder	contraindication	303011007	DOID:1227
Bone marrow depression	contraindication	307762000
Functional visual loss	contraindication	313165001
Breastfeeding (mother)	contraindication	413712001
Significant Bleeding	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4019478	VUID
N0000147598	NUI
D01363	KEGG_DRUG
4019478	VANDF
C0079083	UMLSCUI
CHEBI:31355	CHEBI
QPT	PDB_CHEM_ID
CHEMBL1351	ChEMBL_ID
CHEMBL288376	ChEMBL_ID
D016190	MESH_DESCRIPTOR_UI
DB00958	DRUGBANK_ID
7624	IUPHAR_LIGAND_ID
5231	INN_ID
BG3F62OND5	UNII
426756	PUBCHEM_CID
152200	RXNORM
3186	MMSL
37674	MMSL
4357	MMSL
d00185	MMSL
002643	NDDF
108759002	SNOMEDCT_US
386905002	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
CARBOplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-4239	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	25 sections
CARBOplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-4239	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	25 sections
CARBOplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-4239	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	25 sections
CARBOplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-4239	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	25 sections
CARBOplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-4244	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	25 sections
CARBOplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-4244	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	25 sections
CARBOplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-4244	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	25 sections
CARBOplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-4244	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	25 sections
CARBOplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-4246	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	25 sections
CARBOplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-4246	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	25 sections
CARBOplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-4246	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	25 sections
CARBOplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-4246	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	25 sections
CARBOplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-4248	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	25 sections
CARBOplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-4248	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	25 sections
CARBOplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-4248	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	25 sections
CARBOplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-4248	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	25 sections
CARBOplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-4248	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	25 sections
CARBOplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-4248	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	25 sections
Carboplatin	HUMAN PRESCRIPTION DRUG LABEL	1	16729-295	INJECTION	10 mg	INTRAVENOUS	ANDA	24 sections
carboplatin	Human Prescription Drug Label	1	47335-150	INJECTION	10 mg	INTRAVENOUS	ANDA	22 sections
carboplatin	Human Prescription Drug Label	1	47335-151	INJECTION	10 mg	INTRAVENOUS	ANDA	22 sections
carboplatin	Human Prescription Drug Label	1	47335-284	INJECTION	10 mg	INTRAVENOUS	ANDA	22 sections
carboplatin	Human Prescription Drug Label	1	47335-300	INJECTION	10 mg	INTRAVENOUS	ANDA	22 sections
Carboplatin	HUMAN PRESCRIPTION DRUG LABEL	1	50742-445	INJECTION, SOLUTION	50 mg	INTRAVENOUS	ANDA	21 sections
Carboplatin	HUMAN PRESCRIPTION DRUG LABEL	1	50742-446	INJECTION, SOLUTION	150 mg	INTRAVENOUS	ANDA	21 sections
Carboplatin	HUMAN PRESCRIPTION DRUG LABEL	1	50742-447	INJECTION, SOLUTION	450 mg	INTRAVENOUS	ANDA	21 sections
Carboplatin	HUMAN PRESCRIPTION DRUG LABEL	1	50742-447	INJECTION, SOLUTION	450 mg	INTRAVENOUS	ANDA	21 sections
Carboplatin	HUMAN PRESCRIPTION DRUG LABEL	1	50742-448	INJECTION, SOLUTION	600 mg	INTRAVENOUS	ANDA	21 sections
Carboplatin	HUMAN PRESCRIPTION DRUG LABEL	1	50742-448	INJECTION, SOLUTION	600 mg	INTRAVENOUS	ANDA	21 sections
CARBOPLATIN	HUMAN PRESCRIPTION DRUG LABEL	1	54288-164	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	20 sections