lithium carbonate ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4207 554-13-2

Description:

MoleculeDescription

Synonyms:

  • lithium carbonate
  • carbonic acid, dilithium salt
  • dilithium carbonate
A lithium salt, classified as a mood-stabilizing agent. Lithium ion alters the metabolism of BIOGENIC MONOAMINES in the CENTRAL NERVOUS SYSTEM, and affects multiple neurotransmission systems.
  • Molecular weight: 73.89
  • Formula: CLi2O3
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 63.19
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
24 mmol O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 13 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 95 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 116.00 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
April 6, 1970 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 1461.12 13.06 1368 50629 245882 63191143
Tremor 809.75 13.06 748 51249 131491 63305534
Antipsychotic drug level increased 799.42 13.06 233 51764 3202 63433823
Neuroleptic malignant syndrome 690.69 13.06 287 51710 11769 63425256
Nephrogenic diabetes insipidus 659.90 13.06 154 51843 805 63436220
Drug interaction 636.63 13.06 857 51140 228274 63208751
Mania 549.40 13.06 246 51751 12121 63424904
Extrapyramidal disorder 516.99 13.06 241 51756 13043 63423982
Sopor 362.48 13.06 226 51771 21938 63415087
Agitation 345.68 13.06 328 51669 59429 63377596
Drug abuse 343.56 13.06 357 51640 72161 63364864
Hypomania 320.22 13.06 138 51859 6192 63430833
Psychotic disorder 312.95 13.06 218 51779 25494 63411531
Antipsychotic drug level above therapeutic 306.94 13.06 85 51912 958 63436067
Ataxia 302.96 13.06 176 51821 15019 63422006
Hyperparathyroidism 293.14 13.06 103 51894 2646 63434379
Completed suicide 279.86 13.06 459 51538 145214 63291811
Confusional state 279.61 13.06 605 51392 235775 63201250
Suicidal ideation 273.76 13.06 295 51702 62126 63374899
Tardive dyskinesia 272.35 13.06 135 51862 8367 63428658
Sedation 263.33 13.06 233 51764 38576 63398449
Schizophrenia 260.74 13.06 138 51859 9814 63427211
Intentional self-injury 253.87 13.06 192 51805 25495 63411530
Pain 237.98 13.06 158 51839 740470 62696555
Suicide attempt 234.58 13.06 269 51728 60649 63376376
Overdose 228.24 13.06 368 51629 114710 63322315
Dysarthria 225.41 13.06 223 51774 42488 63394537
Parkinsonism 218.99 13.06 125 51872 10314 63426711
Bipolar disorder 218.84 13.06 114 51883 7846 63429179
Akathisia 212.19 13.06 117 51880 9029 63427996
Hypernatraemia 206.40 13.06 108 51889 7501 63429524
Muscle rigidity 197.47 13.06 121 51876 11379 63425646
Serotonin syndrome 196.14 13.06 173 51824 28509 63408516
Catatonia 185.92 13.06 85 51912 4392 63432633
Somnolence 183.85 13.06 433 51564 178252 63258773
Salivary hypersecretion 180.40 13.06 99 51898 7567 63429458
Aggression 179.48 13.06 151 51846 23347 63413678
Disorientation 179.16 13.06 190 51807 39262 63397763
Myoclonus 177.91 13.06 128 51869 15740 63421285
Arthralgia 172.85 13.06 129 51868 569581 62867444
Delusion 172.75 13.06 113 51884 11904 63425121
Diabetes insipidus 169.07 13.06 68 51929 2557 63434468
Pleurothotonus 164.97 13.06 56 51941 1293 63435732
Intentional overdose 163.42 13.06 249 51748 73903 63363122
Drug level increased 163.22 13.06 141 51856 22595 63414430
Infusion related reaction 158.46 13.06 11 51986 245510 63191515
Hallucination, auditory 154.29 13.06 108 51889 12716 63424309
Altered state of consciousness 152.51 13.06 142 51855 25088 63411937
Dyspnoea 149.60 13.06 194 51803 661119 62775906
Systemic lupus erythematosus 148.70 13.06 5 51992 208913 63228112
Rheumatoid arthritis 148.66 13.06 17 51980 253802 63183223
Polyuria 146.97 13.06 90 51907 8452 63428573
Disturbance in attention 140.86 13.06 165 51832 38024 63399001
Electrocardiogram QT prolonged 136.98 13.06 204 51793 59326 63377699
Arthropathy 136.81 13.06 16 51981 234776 63202249
Joint swelling 136.50 13.06 49 51948 327617 63109408
Swelling 135.38 13.06 30 51967 275348 63161677
Delirium 129.11 13.06 182 51815 50359 63386666
Contraindicated product administered 128.89 13.06 14 51983 217634 63219391
Glossodynia 128.29 13.06 4 51993 178872 63258153
Hypersensitivity 121.49 13.06 44 51953 292641 63144384
Alopecia 117.78 13.06 65 51932 337471 63099554
Restlessness 116.59 13.06 132 51865 29321 63407704
Nasopharyngitis 114.74 13.06 33 51964 254224 63182801
Abdominal discomfort 113.10 13.06 61 51936 320824 63116201
Mental status changes 112.29 13.06 150 51847 39449 63397576
Irritability 112.02 13.06 134 51863 31560 63405465
Abnormal behaviour 111.38 13.06 111 51886 21315 63415710
Polydipsia 106.50 13.06 54 51943 3510 63433515
Bradyphrenia 106.13 13.06 68 51929 6912 63430113
Jaundice cholestatic 105.58 13.06 69 51928 7255 63429770
Drug intolerance 105.42 13.06 61 51936 308600 63128425
Body tinea 104.96 13.06 44 51953 1841 63435184
Dyskinesia 102.90 13.06 129 51868 31873 63405152
Coma 101.41 13.06 186 51811 64178 63372847
Speech disorder 100.36 13.06 144 51853 40485 63396540
Sinusitis 99.38 13.06 31 51966 226622 63210403
Camptocormia 99.35 13.06 27 51970 282 63436743
Hypothyroidism 97.91 13.06 146 51851 42486 63394539
Obsessive-compulsive disorder 97.10 13.06 53 51944 4007 63433018
Inhibitory drug interaction 96.49 13.06 47 51950 2802 63434223
Neurotoxicity 93.86 13.06 91 51906 16899 63420126
Granulocytopenia 93.10 13.06 58 51939 5614 63431411
Depression 91.98 13.06 361 51636 196131 63240894
Peripheral swelling 91.59 13.06 52 51945 265890 63171135
Encephalopathy 91.19 13.06 134 51863 38486 63398539
Treatment failure 89.47 13.06 26 51971 199017 63238008
Psychomotor hyperactivity 88.66 13.06 72 51925 10591 63426434
Hyperreflexia 88.22 13.06 57 51940 5877 63431148
Fatigue 87.98 13.06 402 51595 887626 62549399
Depressed level of consciousness 86.18 13.06 170 51827 61908 63375117
Weight increased 85.63 13.06 431 51566 260361 63176664
Poisoning 84.51 13.06 78 51919 13622 63423403
Depressed mood 84.34 13.06 132 51865 40059 63396966
Mental disorder 82.56 13.06 104 51893 25815 63411210
Acute kidney injury 82.07 13.06 429 51568 262986 63174039
Pyramidal tract syndrome 81.69 13.06 24 51973 339 63436686
Glucose tolerance impaired 80.53 13.06 56 51941 6521 63430504
Dystonia 80.09 13.06 76 51921 13743 63423282
Hypercalcaemia 79.85 13.06 107 51890 28215 63408810
Pruritus 79.47 13.06 108 51889 361345 63075680
Infection susceptibility increased 78.81 13.06 44 51953 3477 63433548
Rash 78.69 13.06 219 51778 560652 62876373
Postural tremor 78.08 13.06 23 51974 328 63436697
Mutism 77.42 13.06 34 51963 1596 63435429
Stomatitis 77.03 13.06 11 51986 138714 63298311
Libido increased 73.57 13.06 31 51966 1314 63435711
Aphasia 71.50 13.06 110 51887 32890 63404135
Apathy 70.22 13.06 58 51939 8736 63428289
Cough 70.02 13.06 82 51915 292661 63144364
Infection 69.12 13.06 52 51945 229121 63207904
Blood prolactin increased 68.28 13.06 40 51957 3463 63433562
Bradykinesia 67.84 13.06 46 51951 5142 63431883
Antipsychotic drug level below therapeutic 67.72 13.06 20 51977 288 63436737
Electroencephalogram abnormal 66.53 13.06 40 51957 3632 63433393
Anaemia 66.17 13.06 86 51911 293344 63143681
Drug reaction with eosinophilia and systemic symptoms 65.33 13.06 107 51890 33729 63403296
Therapeutic product effect decreased 64.74 13.06 39 51958 193148 63243877
Back pain 64.23 13.06 73 51924 264072 63172953
Grandiosity 63.86 13.06 19 51978 281 63436744
Poor quality sleep 63.50 13.06 80 51917 19855 63417170
Logorrhoea 63.46 13.06 34 51963 2476 63434549
Disease progression 63.11 13.06 12 51985 122746 63314279
Treatment noncompliance 62.77 13.06 111 51886 37214 63399811
Cerebellar syndrome 62.70 13.06 38 51959 3501 63433524
Leukocytosis 62.69 13.06 91 51906 25844 63411181
Cogwheel rigidity 62.25 13.06 31 51966 1939 63435086
Nephropathy 61.74 13.06 47 51950 6294 63430731
Paranoia 61.61 13.06 61 51936 11618 63425407
Parathyroid tumour benign 60.86 13.06 23 51974 730 63436295
Pain in extremity 60.57 13.06 112 51885 331374 63105651
Psychiatric symptom 60.53 13.06 43 51954 5180 63431845
Brugada syndrome 59.05 13.06 19 51978 369 63436656
Stupor 58.52 13.06 39 51958 4236 63432789
Gestational diabetes 58.09 13.06 51 51946 8345 63428680
Impaired healing 57.23 13.06 8 51989 102534 63334491
Galactorrhoea 57.11 13.06 38 51959 4117 63432908
Tachyphrenia 56.77 13.06 26 51971 1348 63435677
Blister 56.42 13.06 18 51979 129796 63307229
Anxiety 55.57 13.06 336 51661 217205 63219820
Malignant neoplasm progression 54.97 13.06 3 51994 82118 63354907
Bipolar I disorder 54.50 13.06 28 51969 1871 63435154
Discomfort 54.40 13.06 35 51962 167339 63269686
Febrile neutropenia 54.07 13.06 15 51982 118434 63318591
Death 54.04 13.06 144 51853 374237 63062788
Anticholinergic syndrome 53.95 13.06 30 51967 2352 63434673
Product use issue 53.53 13.06 61 51936 220459 63216566
Intentional product use issue 53.38 13.06 19 51978 127873 63309152
Chronic kidney disease 53.23 13.06 116 51881 45282 63391743
Electrocardiogram T wave abnormal 53.19 13.06 30 51967 2417 63434608
Psychiatric decompensation 53.19 13.06 25 51972 1376 63435649
Cardio-respiratory arrest 52.74 13.06 137 51860 59822 63377203
Withdrawal syndrome 52.51 13.06 73 51924 19924 63417101
Persecutory delusion 52.13 13.06 31 51966 2759 63434266
Hostility 51.99 13.06 27 51970 1845 63435180
Resting tremor 51.90 13.06 21 51976 802 63436223
White blood cell count increased 51.25 13.06 119 51878 48442 63388583
Behaviour disorder 50.71 13.06 32 51965 3167 63433858
Euphoric mood 49.30 13.06 37 51960 4850 63432175
Blood creatine phosphokinase increased 49.25 13.06 89 51908 30341 63406684
Enuresis 49.15 13.06 29 51968 2544 63434481
Poisoning deliberate 49.09 13.06 53 51944 11165 63425860
Headache 49.00 13.06 311 51686 632930 62804095
Mental impairment 48.63 13.06 59 51938 14092 63422933
Hyperlipidaemia 47.78 13.06 69 51928 19502 63417523
Gastrointestinal disorder 47.57 13.06 24 51973 131215 63305810
Hypothermia 47.28 13.06 57 51940 13524 63423501
Urticaria 46.99 13.06 40 51957 165762 63271263
Cognitive disorder 46.52 13.06 125 51872 55690 63381335
Anger 46.21 13.06 54 51943 12402 63424623
Neutrophil count increased 45.91 13.06 62 51935 16465 63420560
Atrial fibrillation 45.90 13.06 19 51978 116617 63320408
Urinary retention 45.74 13.06 86 51911 30215 63406810
Personality disorder 45.72 13.06 38 51959 5773 63431252
Arthritis 45.43 13.06 19 51978 115902 63321123
Action tremor 45.21 13.06 15 51982 322 63436703
Schizoaffective disorder 45.19 13.06 31 51966 3531 63433494
Drooling 45.18 13.06 32 51965 3836 63433189
Psoriatic arthropathy 44.85 13.06 10 51987 91510 63345515
Sleep-related eating disorder 44.50 13.06 19 51978 832 63436193
Bundle branch block right 44.21 13.06 35 51962 4963 63432062
Hallucination, visual 44.17 13.06 66 51931 19232 63417793
Hallucination 43.92 13.06 121 51876 54696 63382329
Renal cyst 43.90 13.06 48 51949 10254 63426771
Substance abuse 43.25 13.06 34 51963 4773 63432252
Oculogyric crisis 42.64 13.06 23 51974 1698 63435327
Lower respiratory tract infection 42.53 13.06 28 51969 132279 63304746
Purpura 41.64 13.06 49 51948 11336 63425689
Abdominal pain upper 41.09 13.06 66 51931 206378 63230647
Psychomotor skills impaired 40.86 13.06 25 51972 2343 63434682
Soft tissue injury 40.71 13.06 22 51975 1630 63435395
Lethargy 40.37 13.06 119 51878 55888 63381137
Mobility decreased 39.82 13.06 25 51972 121134 63315891
Gastrointestinal haemorrhage 39.52 13.06 9 51988 81167 63355858
Fibromyalgia 38.98 13.06 9 51988 80411 63356614
Parkinsonian gait 38.88 13.06 15 51982 504 63436521
Diarrhoea 38.78 13.06 387 51610 714979 62722046
Impaired quality of life 38.73 13.06 52 51945 13731 63423294
Asterixis 38.34 13.06 20 51977 1379 63435646
Cholelithiasis 38.25 13.06 100 51897 43825 63393200
Hyperprolactinaemia 38.17 13.06 29 51968 3871 63433154
Hypertonia 37.89 13.06 31 51966 4606 63432419
International normalised ratio abnormal 37.82 13.06 27 51970 3277 63433748
Urinary incontinence 37.75 13.06 82 51915 31932 63405093
Goitre 36.88 13.06 34 51963 5927 63431098
Chest pain 36.77 13.06 76 51921 215883 63221142
Electrocardiogram T wave inversion 36.56 13.06 27 51970 3454 63433571
Sinus bradycardia 36.54 13.06 52 51945 14499 63422526
Protein C increased 36.41 13.06 10 51987 109 63436916
COVID-19 36.26 13.06 24 51973 113079 63323946
Impulsive behaviour 36.02 13.06 20 51977 1563 63435462
Thinking abnormal 35.96 13.06 44 51953 10599 63426426
Insomnia 35.93 13.06 300 51697 214952 63222073
Asthma 35.86 13.06 31 51966 127530 63309495
Visuospatial deficit 35.42 13.06 7 51990 13 63437012
Haemodialysis 35.23 13.06 40 51957 8907 63428118
Osteoarthritis 35.20 13.06 17 51980 95326 63341699
Choreoathetosis 35.09 13.06 14 51983 515 63436510
Cardiac failure congestive 34.87 13.06 16 51981 92417 63344608
Miosis 34.40 13.06 36 51961 7317 63429708
Bronchitis 34.35 13.06 31 51966 124904 63312121
Interstitial lung disease 34.14 13.06 5 51992 61903 63375122
Drug withdrawal syndrome 33.61 13.06 71 51926 27123 63409902
Post-traumatic neck syndrome 33.51 13.06 21 51976 2053 63434972
Hepatotoxicity 32.94 13.06 85 51912 36956 63400069
Impaired self-care 32.92 13.06 20 51977 1850 63435175
Blood sodium increased 32.84 13.06 23 51974 2709 63434316
Muscle twitching 32.43 13.06 58 51939 19610 63417415
Hypokinesia 32.37 13.06 48 51949 13888 63423137
Respiratory arrest 32.28 13.06 78 51919 32567 63404458
Rhabdomyolysis 32.26 13.06 94 51903 43857 63393168
Myocarditis 32.19 13.06 41 51956 10284 63426741
Drug hypersensitivity 32.15 13.06 138 51859 310549 63126476
Injection site erythema 32.00 13.06 14 51983 83160 63353865
Pneumonia 31.93 13.06 231 51766 456536 62980489
Sternal fracture 31.91 13.06 21 51976 2233 63434792
Blood bilirubin increased 31.77 13.06 84 51913 37056 63399969
Reflexes abnormal 31.68 13.06 14 51983 667 63436358
Mood swings 31.62 13.06 55 51942 18193 63418832
Renal oncocytoma 31.52 13.06 7 51990 28 63436997
Neuropathy peripheral 31.49 13.06 28 51969 113639 63323386
Hereditary ataxia 30.94 13.06 7 51990 31 63436994
Knee arthroplasty 30.78 13.06 4 51993 54202 63382823
Impaired work ability 30.71 13.06 53 51944 17422 63419603
Maternal exposure during pregnancy 30.69 13.06 86 51911 219976 63217049
Hyperthyroidism 30.50 13.06 48 51949 14625 63422400
Paraesthesia 30.46 13.06 51 51946 156915 63280110
Cerebellar atrophy 30.42 13.06 14 51983 734 63436291
Gait disturbance 30.40 13.06 255 51742 182923 63254102
Schizoaffective disorder bipolar type 30.26 13.06 9 51988 133 63436892
Clonus 29.77 13.06 27 51970 4609 63432416
Electrocardiogram abnormal 29.49 13.06 37 51960 9142 63427883
Papillary thyroid cancer 29.49 13.06 20 51977 2236 63434789
Musculoskeletal pain 29.02 13.06 20 51977 92257 63344768
Induced abortion failed 29.01 13.06 10 51987 242 63436783
Drug level above therapeutic 28.94 13.06 27 51970 4778 63432247
Hallucinations, mixed 28.82 13.06 27 51970 4802 63432223
Self-injurious ideation 28.77 13.06 21 51976 2638 63434387
Social avoidant behaviour 28.77 13.06 22 51975 2966 63434059
General physical health deterioration 28.60 13.06 78 51919 201324 63235701
Depressive symptom 28.54 13.06 25 51972 4077 63432948
Irritable bowel syndrome 28.49 13.06 16 51981 82396 63354629
Adams-Stokes syndrome 27.88 13.06 7 51990 52 63436973
Status epilepticus 27.83 13.06 47 51950 15186 63421839
Pressure of speech 27.70 13.06 13 51984 713 63436312
Mood altered 27.61 13.06 46 51951 14697 63422328
Acute psychosis 27.45 13.06 20 51977 2505 63434520
Dialysis 27.28 13.06 38 51959 10389 63426636
Eye movement disorder 27.01 13.06 27 51970 5201 63431824
Deprescribing error 26.82 13.06 6 51991 25 63437000
Differential white blood cell count abnormal 26.72 13.06 13 51984 773 63436252
Bone density decreased 26.58 13.06 45 51952 14567 63422458
Increased appetite 26.55 13.06 36 51961 9594 63427431
Nodal rhythm 26.54 13.06 17 51980 1726 63435299
Nystagmus 26.54 13.06 29 51968 6191 63430834
Abdominal pain 26.44 13.06 137 51860 293319 63143706
Injection site pruritus 26.43 13.06 3 51994 45113 63391912
Lung disorder 26.40 13.06 9 51988 62252 63374773
Ileus paralytic 26.31 13.06 25 51972 4526 63432499
Hypotonia 26.04 13.06 35 51962 9250 63427775
Hyperthermia malignant 25.98 13.06 13 51984 821 63436204
Persistent depressive disorder 25.92 13.06 14 51983 1036 63435989
Thrombocytopenia 25.88 13.06 53 51944 151104 63285921
Injection site swelling 25.87 13.06 4 51993 47568 63389457
Language disorder 25.53 13.06 18 51979 2142 63434883
Thyrotoxic crisis 25.38 13.06 13 51984 863 63436162
Ill-defined disorder 25.33 13.06 18 51979 81737 63355288
Affect lability 25.32 13.06 38 51959 11113 63425912
Major depression 25.25 13.06 32 51965 7986 63429039
Platelet count decreased 25.15 13.06 35 51962 116087 63320938
International normalised ratio increased 25.03 13.06 4 51993 46421 63390604
Myocarditis septic 25.00 13.06 6 51991 36 63436989
Cerebrovascular accident 24.99 13.06 31 51966 107993 63329032
Neonatal respiratory distress 24.64 13.06 10 51987 385 63436640
Off label use 24.49 13.06 397 51600 674065 62762960
Cerebral atrophy 24.05 13.06 25 51972 5041 63431984
Feeling guilty 24.01 13.06 11 51986 571 63436454
Nephropathy toxic 23.99 13.06 34 51963 9445 63427580
Ammonia increased 23.97 13.06 24 51973 4632 63432393
Conversion disorder 23.92 13.06 16 51981 1748 63435277
Muscle contractions involuntary 23.88 13.06 18 51979 2374 63434651
Electric shock sensation 23.72 13.06 12 51985 776 63436249
Hypotonia neonatal 23.69 13.06 14 51983 1232 63435793
Ideas of reference 23.56 13.06 7 51990 103 63436922
Bruxism 23.56 13.06 21 51976 3504 63433521
Toxic encephalopathy 23.54 13.06 28 51969 6551 63430474
Sepsis 23.51 13.06 57 51940 153066 63283959
Sluggishness 23.24 13.06 25 51972 5244 63431781
Antidepressant drug level increased 23.20 13.06 9 51988 307 63436718
Encopresis 23.08 13.06 7 51990 111 63436914
Histrionic personality disorder 22.88 13.06 6 51991 54 63436971
Poverty of speech 22.87 13.06 9 51988 319 63436706
Injection site pain 22.66 13.06 45 51952 129755 63307270
Skin disorder 22.51 13.06 64 51933 29443 63407582
Compulsive sexual behaviour 22.50 13.06 6 51991 58 63436967
Pleural effusion 22.36 13.06 26 51971 93184 63343841
Electroconvulsive therapy 22.22 13.06 6 51991 61 63436964
Nausea 21.95 13.06 533 51464 853938 62583087
Coordination abnormal 21.92 13.06 40 51957 13733 63423292
Oscillopsia 21.75 13.06 7 51990 136 63436889
Flat affect 21.73 13.06 14 51983 1436 63435589
Hyperammonaemia 21.64 13.06 24 51973 5208 63431817
Tachycardia 21.49 13.06 168 51829 117988 63319037
Mucosal inflammation 21.30 13.06 6 51991 46922 63390103
Anaphylactic reaction 21.22 13.06 14 51983 66086 63370939
Blunted affect 21.13 13.06 8 51989 255 63436770
Renal impairment 20.96 13.06 134 51863 88221 63348804
Long QT syndrome 20.86 13.06 19 51978 3260 63433765
Mydriasis 20.67 13.06 36 51961 11920 63425105
Merycism 20.62 13.06 8 51989 273 63436752
Seizure 20.61 13.06 182 51815 132452 63304573
Water intoxication 20.58 13.06 9 51988 418 63436607
Hyporeflexia 20.58 13.06 15 51982 1880 63435145
Liver injury 20.56 13.06 12 51985 60508 63376517
Borderline personality disorder 20.54 13.06 11 51986 800 63436225
Wheezing 20.51 13.06 29 51968 95566 63341459
Electrocardiogram repolarisation abnormality 20.44 13.06 13 51984 1304 63435721
Megacolon 20.44 13.06 15 51982 1900 63435125
Lactate pyruvate ratio increased 20.09 13.06 6 51991 90 63436935
Bone pain 19.78 13.06 10 51987 54631 63382394
Drug ineffective 19.71 13.06 680 51317 1044085 62392940
Disinhibition 19.67 13.06 11 51986 872 63436153
Rhinorrhoea 19.59 13.06 15 51982 65562 63371463
Productive cough 19.47 13.06 14 51983 63194 63373831
Drug level decreased 19.44 13.06 28 51969 7891 63429134
Delusion of reference 19.39 13.06 6 51991 102 63436923
Limbic encephalitis 19.35 13.06 8 51989 323 63436702
Homicidal ideation 19.33 13.06 14 51983 1738 63435287
Dysphoria 19.21 13.06 22 51975 4944 63432081
Hyperthermia 19.10 13.06 30 51967 9126 63427899
Irregular sleep wake rhythm disorder 19.08 13.06 7 51990 204 63436821
Unresponsive to stimuli 19.02 13.06 66 51931 33750 63403275
Refusal of treatment by patient 19.02 13.06 23 51974 5474 63431551
Cardiac arrest 18.76 13.06 135 51862 92410 63344615
Influenza 18.71 13.06 38 51959 108684 63328341
Agranulocytosis 18.68 13.06 54 51943 25080 63411945
Throat irritation 18.67 13.06 4 51993 37643 63399382
Skin ulcer 18.64 13.06 6 51991 43039 63393986
Inflammation 18.62 13.06 24 51973 82249 63354776
Affective disorder 18.52 13.06 24 51973 6122 63430903
Lipids decreased 18.43 13.06 4 51993 14 63437011
Arachnoid cyst 18.32 13.06 7 51990 229 63436796
Neuropsychiatric symptoms 18.23 13.06 10 51987 763 63436262
Psychomotor retardation 18.20 13.06 19 51978 3851 63433174
Balance disorder 18.19 13.06 125 51872 84297 63352728
Somatic symptom disorder 18.08 13.06 16 51981 2644 63434381
Urine osmolarity increased 18.03 13.06 6 51991 130 63436895
Bradycardia 17.96 13.06 112 51885 73115 63363910
Staring 17.93 13.06 13 51984 1617 63435408
Blood citric acid increased 17.84 13.06 5 51992 59 63436966
Dyspnoea exertional 17.75 13.06 14 51983 60288 63376737
Acquired cystic kidney disease 17.69 13.06 5 51992 61 63436964
Negativism 17.57 13.06 8 51989 409 63436616
Essential tremor 17.54 13.06 11 51986 1077 63435948
Hallucination, olfactory 17.53 13.06 7 51990 258 63436767
Medication error 17.51 13.06 87 51910 52197 63384828
Alcohol interaction 17.40 13.06 15 51982 2394 63434631
Psychotic disorder due to a general medical condition 17.26 13.06 7 51990 269 63436756
Cardiac failure 17.25 13.06 29 51968 89113 63347912
Antidepressant drug level above therapeutic 17.21 13.06 8 51989 429 63436596
Ear infection 17.13 13.06 5 51992 38208 63398817
Stereotypy 17.13 13.06 8 51989 434 63436591
Distractibility 17.09 13.06 8 51989 436 63436589
Blood urea increased 17.08 13.06 54 51943 26325 63410700
Joint range of motion decreased 17.02 13.06 3 51994 32425 63404600
Muscle spasms 16.97 13.06 68 51929 156082 63280943
Pneumonitis 16.95 13.06 4 51993 35218 63401807
Epileptic encephalopathy 16.76 13.06 7 51990 290 63436735
Loss of personal independence in daily activities 16.74 13.06 34 51963 97256 63339769
Clear cell renal cell carcinoma 16.69 13.06 12 51985 1473 63435552
Upper respiratory tract infection 16.53 13.06 26 51971 82021 63355004
Retroperitoneal fibrosis 16.49 13.06 7 51990 302 63436723
Colectomy total 16.42 13.06 6 51991 173 63436852
Slow speech 16.37 13.06 12 51985 1517 63435508
Potentiating drug interaction 16.35 13.06 19 51978 4337 63432688
Haematochezia 16.31 13.06 12 51985 53532 63383493
Acalculia 16.25 13.06 3 51994 3 63437022
Neutrophilia 16.17 13.06 19 51978 4387 63432638
Compartment syndrome 16.05 13.06 14 51983 2270 63434755
Osteoporosis 16.03 13.06 14 51983 57324 63379701
Blood pressure fluctuation 15.99 13.06 9 51988 46308 63390717
Cystitis 15.89 13.06 13 51984 54978 63382047
Food craving 15.85 13.06 12 51985 1594 63435431
Tonsillar hypertrophy 15.83 13.06 10 51987 991 63436034
Haemorrhage 15.76 13.06 16 51981 61006 63376019
Pain in jaw 15.68 13.06 8 51989 43488 63393537
Antipsychotic drug level decreased 15.60 13.06 7 51990 346 63436679
Foetal malnutrition 15.59 13.06 5 51992 96 63436929
Slow response to stimuli 15.55 13.06 10 51987 1022 63436003
Plasma cell myeloma 15.55 13.06 5 51992 35900 63401125
Hypoaesthesia 15.49 13.06 78 51919 168315 63268710
Ileus 15.44 13.06 36 51961 14689 63422336
Ascites 15.43 13.06 7 51990 40721 63396304
Breast engorgement 15.35 13.06 5 51992 101 63436924
Malaise 15.32 13.06 244 51753 415710 63021315
Blood pressure systolic increased 15.26 13.06 10 51987 47387 63389638
Hyperhidrosis 15.24 13.06 145 51852 107691 63329334
Blood cholesterol increased 15.23 13.06 34 51963 93998 63343027
Decreased appetite 15.16 13.06 132 51865 250920 63186105
Thyroiditis 15.13 13.06 14 51983 2452 63434573
Urine output increased 15.07 13.06 11 51986 1382 63435643
Neurological symptom 15.01 13.06 21 51976 5762 63431263
Joint injury 14.96 13.06 3 51994 29569 63407456
Echolalia 14.96 13.06 6 51991 224 63436801
Gaze palsy 14.88 13.06 11 51986 1409 63435616
Atrial septal defect 14.84 13.06 23 51974 6915 63430110
Movement disorder 14.64 13.06 45 51952 21616 63415409
Sexually inappropriate behaviour 14.51 13.06 5 51992 121 63436904
Sciatica 14.48 13.06 5 51992 34319 63402706
Distal intestinal obstruction syndrome 14.47 13.06 7 51990 411 63436614
Delusional perception 14.45 13.06 6 51991 245 63436780
Drug eruption 14.44 13.06 54 51943 28640 63408385
Injection site reaction 14.39 13.06 16 51981 58508 63378517
Glomerulonephritis minimal lesion 14.36 13.06 6 51991 249 63436776
Stevens-Johnson syndrome 14.30 13.06 49 51948 24901 63412124
Cerebellar ataxia 14.24 13.06 9 51988 893 63436132
Cardiomyopathy acute 14.18 13.06 6 51991 257 63436768
Thought insertion 14.17 13.06 3 51994 9 63437016
Dysphemia 14.16 13.06 14 51983 2661 63434364
Memory impairment 14.15 13.06 139 51858 104119 63332906
Incoherent 14.14 13.06 18 51979 4512 63432513
Polyhydramnios 14.14 13.06 13 51984 2258 63434767
Oral herpes 13.90 13.06 50 51947 26024 63411001
Muscle tone disorder 13.85 13.06 5 51992 139 63436886
Gambling disorder 13.80 13.06 10 51987 1242 63435783
Amimia 13.71 13.06 4 51993 55 63436970
Unmasking of previously unidentified disease 13.59 13.06 9 51988 967 63436058
Decreased activity 13.59 13.06 21 51976 6299 63430726
Amenorrhoea 13.57 13.06 27 51970 9887 63427138
Melaena 13.56 13.06 4 51993 30361 63406664
Night sweats 13.55 13.06 12 51985 48802 63388223
Tooth injury 13.52 13.06 10 51987 1282 63435743
Congenital aqueductal stenosis 13.51 13.06 3 51994 12 63437013
Dry skin 13.50 13.06 16 51981 56871 63380154
Localised infection 13.46 13.06 4 51993 30206 63406819
Nocturia 13.41 13.06 24 51973 8117 63428908
Abulia 13.37 13.06 7 51990 486 63436539
Osteonecrosis of jaw 13.37 13.06 6 51991 35117 63401908
Sinus tachycardia 13.33 13.06 47 51950 24221 63412804
Hypoxic-ischaemic encephalopathy 13.33 13.06 17 51980 4270 63432755
Progressive supranuclear palsy 13.27 13.06 4 51993 62 63436963
Radial nerve palsy 13.23 13.06 7 51990 497 63436528
Brain injury 13.22 13.06 22 51975 7021 63430004
Thought blocking 13.22 13.06 5 51992 159 63436866
Femur fracture 13.19 13.06 9 51988 41747 63395278
Haematoma 13.17 13.06 6 51991 34814 63402211
Divorced 13.13 13.06 3 51994 14 63437011
Nightmare 13.08 13.06 40 51957 19154 63417871

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 886.18 13.80 1111 38677 199251 34717892
Neuroleptic malignant syndrome 598.85 13.80 326 39462 17608 34899535
Antipsychotic drug level increased 572.09 13.80 201 39587 3664 34913479
Tremor 536.14 13.80 560 39228 82027 34835116
Mania 496.63 13.80 234 39554 9277 34907866
Nephrogenic diabetes insipidus 398.49 13.80 118 39670 1203 34915940
Akathisia 370.25 13.80 182 39606 7927 34909216
Suicide attempt 354.65 13.80 319 39469 38797 34878346
Obsessive-compulsive disorder 331.32 13.80 150 39638 5414 34911729
Antipsychotic drug level below therapeutic 311.32 13.80 115 39673 2432 34914711
Extrapyramidal disorder 276.41 13.80 176 39612 12704 34904439
Parkinsonism 252.39 13.80 141 39647 7997 34909146
Drug interaction 235.74 13.80 675 39113 225271 34691872
Disinhibition 230.94 13.80 99 39689 3127 34914016
Euphoric mood 220.51 13.80 114 39674 5527 34911616
Serotonin syndrome 211.66 13.80 178 39610 19755 34897388
Therapeutic product effect variable 211.55 13.80 86 39702 2370 34914773
Increased appetite 199.00 13.80 117 39671 7312 34909831
Antipsychotic drug level above therapeutic 189.61 13.80 66 39722 1167 34915976
Psychotic disorder 184.15 13.80 180 39608 24272 34892871
Dysarthria 170.40 13.80 204 39584 34578 34882565
Psychomotor hyperactivity 166.50 13.80 115 39673 9507 34907636
Suicidal ideation 166.10 13.80 217 39571 40171 34876972
Agitation 162.16 13.80 258 39530 57141 34860002
Weight increased 158.54 13.80 336 39452 92697 34824446
Granulocytopenia 151.56 13.80 94 39694 6473 34910670
Hypomania 148.07 13.80 66 39722 2293 34914850
Sedation 144.08 13.80 147 39641 20859 34896284
Confusional state 142.51 13.80 423 39365 143737 34773406
Irritability 141.41 13.80 157 39631 24533 34892610
Diabetes insipidus 140.46 13.80 68 39720 2860 34914283
Aggression 136.93 13.80 194 39594 38770 34878373
Febrile neutropenia 124.29 13.80 8 39780 136841 34780302
Ataxia 123.47 13.80 112 39676 13741 34903402
Dyspnoea 122.27 13.80 150 39638 376632 34540511
Dyskinesia 120.64 13.80 138 39650 22275 34894868
Schizophrenia 118.93 13.80 90 39698 8576 34908567
Salivary hypersecretion 112.54 13.80 87 39701 8557 34908586
Bipolar disorder 109.48 13.80 62 39726 3607 34913536
Leukopenia 108.12 13.80 228 39560 62628 34854515
Delusion 104.54 13.80 98 39690 12537 34904606
Hallucination, auditory 103.56 13.80 95 39693 11822 34905321
Completed suicide 100.65 13.80 292 39496 97876 34819267
Death 99.71 13.80 189 39599 397860 34519283
Myoclonus 99.06 13.80 102 39686 14623 34902520
Tardive dyskinesia 97.35 13.80 68 39720 5722 34911421
Arthralgia 95.63 13.80 37 39751 170004 34747139
Hypernatraemia 92.53 13.80 77 39711 8413 34908730
Muscle rigidity 89.75 13.80 83 39705 10435 34906708
Schizoaffective disorder 89.33 13.80 39 39749 1288 34915855
Overdose 88.69 13.80 266 39522 90793 34826350
Bruxism 85.35 13.80 41 39747 1694 34915449
Anaemia 84.16 13.80 85 39703 233250 34683893
White blood cell count increased 83.56 13.80 160 39628 40991 34876152
Hyperparathyroidism 82.48 13.80 36 39752 1188 34915955
Priapism 82.44 13.80 58 39730 4936 34912207
Cough 82.23 13.80 34 39754 150106 34767037
Catatonia 82.12 13.80 58 39730 4967 34912176
Dyslipidaemia 81.79 13.80 68 39720 7420 34909723
Disease progression 78.74 13.80 14 39774 108063 34809080
Somnolence 76.64 13.80 289 39499 110827 34806316
Sopor 76.15 13.80 81 39707 12055 34905088
Delirium 76.10 13.80 160 39628 43831 34873312
Intentional overdose 75.73 13.80 159 39629 43515 34873628
Oppositional defiant disorder 75.32 13.80 27 39761 522 34916621
Coordination abnormal 72.45 13.80 64 39724 7580 34909563
Pain 71.02 13.80 77 39711 204598 34712545
Obesity 70.48 13.80 80 39708 12798 34904345
Decreased eye contact 70.39 13.80 25 39763 470 34916673
Abnormal behaviour 70.11 13.80 112 39676 24857 34892286
Malignant neoplasm progression 67.27 13.80 10 39778 88036 34829107
Neutrophil count increased 67.15 13.80 90 39698 17056 34900087
Pain in extremity 67.10 13.80 30 39758 126483 34790660
Prescribed overdose 66.69 13.80 71 39717 10576 34906567
Mental status changes 66.43 13.80 139 39649 37944 34879199
Homicidal ideation 65.99 13.80 40 39748 2642 34914501
Pneumonia 65.54 13.80 204 39584 362423 34554720
Coma 63.19 13.80 152 39636 45526 34871617
Blood creatine phosphokinase increased 61.76 13.80 149 39639 44708 34872435
Leukaemia 59.19 13.80 46 39742 4557 34912586
Hyperreflexia 57.06 13.80 39 39749 3167 34913976
Polydipsia 56.70 13.80 42 39746 3873 34913270
Cognitive disorder 56.32 13.80 110 39678 28583 34888560
Treatment noncompliance 55.48 13.80 108 39680 27992 34889151
Dystonia 55.36 13.80 65 39723 10780 34906363
Depressed level of consciousness 54.43 13.80 138 39650 42703 34874440
Back pain 54.22 13.80 36 39752 121753 34795390
Restlessness 54.09 13.80 101 39687 25381 34891762
Pancytopenia 52.95 13.80 21 39767 95136 34822007
Speech disorder 52.28 13.80 100 39688 25586 34891557
Affect lability 52.19 13.80 39 39749 3644 34913499
Brugada syndrome 52.16 13.80 23 39765 778 34916365
Atrial fibrillation 52.07 13.80 38 39750 122355 34794788
Disorientation 52.00 13.80 116 39672 33072 34884071
Pruritus 51.94 13.80 51 39737 141930 34775213
Fatigue 51.00 13.80 233 39555 370420 34546723
Interstitial lung disease 50.83 13.80 7 39781 65275 34851868
Peripheral swelling 49.46 13.80 13 39775 76528 34840615
Hypothyroidism 48.35 13.80 86 39702 20816 34896327
Neurotoxicity 48.12 13.80 79 39709 17931 34899212
Anxiety 47.89 13.80 232 39556 99196 34817947
Thinking abnormal 47.71 13.80 46 39742 6091 34911052
Oedema peripheral 47.43 13.80 40 39748 119772 34797371
Disturbance in attention 46.76 13.80 96 39692 25849 34891294
Dystonic tremor 46.71 13.80 15 39773 204 34916939
Myocarditis 44.92 13.80 66 39722 13616 34903527
General physical health deterioration 44.72 13.80 48 39740 128221 34788922
Sepsis 43.36 13.80 77 39711 166484 34750659
Clonus 43.22 13.80 31 39757 2719 34914424
Intentional self-injury 43.16 13.80 65 39723 13706 34903437
Thrombocytopenia 42.72 13.80 70 39718 156177 34760966
Rash 42.51 13.80 122 39666 222630 34694513
Electrocardiogram QRS complex prolonged 42.48 13.80 39 39749 4855 34912288
Paranoia 42.22 13.80 60 39728 12008 34905135
Abulia 41.58 13.80 18 39770 582 34916561
Gastrointestinal haemorrhage 40.94 13.80 25 39763 88452 34828691
Depression 40.76 13.80 218 39570 96880 34820263
Cardiac failure congestive 40.71 13.80 22 39766 83248 34833895
Hyperthermia 40.62 13.80 55 39733 10522 34906621
Infusion related reaction 40.57 13.80 6 39782 53051 34864092
Choreoathetosis 40.13 13.80 21 39767 1043 34916100
Tachycardia foetal 40.12 13.80 15 39773 328 34916815
Cerebellar syndrome 40.03 13.80 28 39760 2360 34914783
Failure to suspend medication 40 13.80 16 39772 422 34916721
Logorrhoea 39.63 13.80 28 39760 2398 34914745
Therapeutic product effect incomplete 39.49 13.80 137 39651 50404 34866739
Insomnia 38.77 13.80 226 39562 103681 34813462
Electrocardiogram QT prolonged 38.28 13.80 118 39670 40834 34876309
Blood thyroid stimulating hormone decreased 37.87 13.80 25 39763 1916 34915227
Apathy 37.82 13.80 43 39745 6889 34910254
Hyperparathyroidism primary 37.59 13.80 12 39776 160 34916983
Myocardial infarction 37.22 13.80 50 39738 121035 34796108
Leukocytosis 36.45 13.80 83 39705 23982 34893161
Delusion of grandeur 35.68 13.80 20 39768 1140 34916003
Joint swelling 35.36 13.80 12 39776 59878 34857265
Drug level above therapeutic 35.14 13.80 33 39755 4228 34912915
Nephropathy 34.50 13.80 38 39750 5879 34911264
Diarrhoea 33.80 13.80 283 39505 389629 34527514
Septic shock 33.65 13.80 20 39768 71814 34845329
Grandiosity 33.53 13.80 13 39775 315 34916828
Enuresis 33.53 13.80 25 39763 2328 34914815
Balance disorder 33.33 13.80 112 39676 40542 34876601
Tachycardia 33.33 13.80 187 39601 84585 34832558
Drug level increased 33.23 13.80 76 39712 22020 34895123
Anger 32.93 13.80 53 39735 11831 34905312
Mental impairment 32.74 13.80 49 39739 10273 34906870
Hyperkinesia 32.64 13.80 22 39766 1746 34915397
Affective disorder 32.61 13.80 32 39756 4328 34912815
Antipsychotic drug level decreased 32.55 13.80 18 39770 999 34916144
Rheumatoid arthritis 32.52 13.80 3 39785 38235 34878908
Abdominal pain 32.38 13.80 88 39700 163530 34753613
Trismus 32.22 13.80 25 39763 2470 34914673
Hyperprolactinaemia 32.22 13.80 21 39767 1575 34915568
Intentional product use issue 31.98 13.80 14 39774 59802 34857341
Distractibility 31.88 13.80 13 39775 361 34916782
Pressure of speech 31.55 13.80 14 39774 481 34916662
Bipolar I disorder 31.02 13.80 16 39772 771 34916372
Patient restraint 30.90 13.80 9 39779 86 34917057
Polyuria 30.54 13.80 43 39745 8531 34908612
Blood prolactin increased 30.35 13.80 21 39767 1739 34915404
Apraxia 30.22 13.80 19 39769 1339 34915804
Thrombosis 29.98 13.80 10 39778 50448 34866695
Melaena 29.50 13.80 3 39785 35377 34881766
Mental disorder 29.46 13.80 58 39730 15151 34901992
Sexual dysfunction 29.25 13.80 36 39752 6267 34910876
Prostate cancer 29.15 13.80 5 39783 39644 34877499
Epistaxis 29.04 13.80 15 39773 58236 34858907
Metabolic syndrome 28.66 13.80 20 39768 1679 34915464
Psychiatric decompensation 28.65 13.80 25 39763 2912 34914231
Restless legs syndrome 28.44 13.80 41 39747 8313 34908830
Bradyphrenia 28.30 13.80 31 39757 4767 34912376
Mucosal inflammation 28.11 13.80 5 39783 38617 34878526
Coronary artery disease 27.96 13.80 10 39778 48295 34868848
Sexually inappropriate behaviour 27.95 13.80 13 39775 499 34916644
Decreased appetite 27.59 13.80 97 39691 166295 34750848
Headache 27.57 13.80 126 39662 200509 34716634
Lethargy 27.50 13.80 106 39682 41016 34876127
Infection 27.47 13.80 38 39750 90877 34826266
Feelings of worthlessness 26.89 13.80 11 39777 308 34916835
Haemoptysis 26.67 13.80 4 39784 35002 34882141
Acute myocardial infarction 26.53 13.80 14 39774 53705 34863438
Depressed mood 26.39 13.80 64 39724 19253 34897890
Blood thyroid stimulating hormone increased 25.98 13.80 28 39760 4227 34912916
Neuropathy peripheral 25.96 13.80 34 39754 83229 34833914
Pleural effusion 25.74 13.80 33 39755 81513 34835630
Drooling 25.63 13.80 25 39763 3357 34913786
Blunted affect 25.60 13.80 11 39777 349 34916794
Plasma cell myeloma 25.56 13.80 8 39780 42029 34875114
Cogwheel rigidity 25.38 13.80 17 39771 1335 34915808
Blood sodium increased 25.31 13.80 23 39765 2825 34914318
Productive cough 25.23 13.80 6 39782 37807 34879336
Flight of ideas 25.11 13.80 11 39777 366 34916777
Muscle spasms 25.10 13.80 29 39759 74972 34842171
Crying 24.85 13.80 32 39756 5830 34911313
Cardiac failure 24.80 13.80 41 39747 91207 34825936
Poisoning deliberate 24.54 13.80 37 39751 7807 34909336
Eosinophil count decreased 24.54 13.80 17 39771 1411 34915732
Otospondylomegaepiphyseal dysplasia 24.44 13.80 8 39780 116 34917027
Off label use 24.38 13.80 334 39454 419190 34497953
Electroconvulsive therapy 24.13 13.80 6 39782 29 34917114
Cerebrovascular accident 24.10 13.80 37 39751 84774 34832369
Metabolic encephalopathy 24.05 13.80 27 39761 4265 34912878
Blood triglycerides increased 23.88 13.80 51 39737 14108 34903035
Musculoskeletal pain 23.56 13.80 4 39784 31959 34885184
Non-high-density lipoprotein cholesterol increased 23.38 13.80 8 39780 134 34917009
Pneumonitis 23.36 13.80 5 39783 33873 34883270
Haemorrhage 23.09 13.80 15 39773 51355 34865788
Hypotonia neonatal 23.08 13.80 16 39772 1329 34915814
Arthritis 22.94 13.80 4 39784 31342 34885801
Angioedema 22.92 13.80 7 39781 37367 34879776
Encephalopathy 22.77 13.80 90 39698 35229 34881914
Altered state of consciousness 22.35 13.80 67 39721 22826 34894317
Self-injurious ideation 22.02 13.80 17 39771 1667 34915476
Anaphylactic reaction 21.80 13.80 5 39783 32296 34884847
Dyspnoea exertional 21.79 13.80 11 39777 43268 34873875
Abdominal distension 21.37 13.80 21 39767 58471 34858672
Erythema 21.35 13.80 43 39745 88737 34828406
Urticaria 21.00 13.80 24 39764 62353 34854790
COVID-19 20.93 13.80 35 39753 77515 34839628
Agranulocytosis 20.75 13.80 67 39721 23754 34893389
Floppy infant 20.64 13.80 7 39781 114 34917029
Sleep disorder 20.63 13.80 81 39707 31607 34885536
Cerebral haemorrhage 20.62 13.80 7 39781 34930 34882213
Chest discomfort 20.60 13.80 19 39769 54511 34862632
Hepatic failure 20.24 13.80 7 39781 34524 34882619
Drug hypersensitivity 20.24 13.80 38 39750 80491 34836652
Diabetes mellitus 20.16 13.80 106 39682 46767 34870376
Urinary incontinence 20.12 13.80 57 39731 18817 34898326
Weight decreased 20.10 13.80 118 39670 176183 34740960
Gambling disorder 20.07 13.80 16 39772 1644 34915499
Hypersensitivity 19.99 13.80 24 39764 61011 34856132
High-grade B-cell lymphoma 19.89 13.80 7 39781 128 34917015
Persistent depressive disorder 19.68 13.80 9 39779 332 34916811
Mood altered 19.64 13.80 36 39752 8916 34908227
Left atrial dilatation 19.49 13.80 17 39771 1979 34915164
Major depression 19.45 13.80 25 39763 4547 34912596
Stupor 19.39 13.80 20 39768 2871 34914272
Psychotic symptom 19.39 13.80 16 39772 1727 34915416
Gait disturbance 19.25 13.80 164 39624 84976 34832167
Upper gastrointestinal haemorrhage 19.24 13.80 3 39785 25515 34891628
Renal cyst 19.23 13.80 36 39752 9057 34908086
Antipsychotic drug level 19.08 13.80 4 39784 7 34917136
Oncocytoma 19.08 13.80 4 39784 7 34917136
Wrong patient received product 18.96 13.80 19 39769 2635 34914508
Bone marrow failure 18.83 13.80 5 39783 29248 34887895
Speech sound disorder 18.68 13.80 7 39781 154 34916989
Staphylococcal infection 18.59 13.80 7 39781 32753 34884390
Convulsive threshold lowered 18.54 13.80 10 39778 528 34916615
Dysphemia 18.49 13.80 15 39773 1580 34915563
Herpes zoster 18.46 13.80 8 39780 34391 34882752
Impulsive behaviour 18.32 13.80 17 39771 2145 34914998
Movement disorder 18.27 13.80 42 39746 12206 34904937
Eosinophil count increased 18.21 13.80 34 39754 8538 34908605
Neutrophilia 18.19 13.80 23 39765 4114 34913029
Nephrolithiasis 18.04 13.80 6 39782 30327 34886816
Poor quality sleep 17.86 13.80 33 39755 8223 34908920
Autonomic nervous system imbalance 17.75 13.80 18 39770 2533 34914610
Secondary tic 17.59 13.80 4 39784 12 34917131
Differential white blood cell count abnormal 17.51 13.80 14 39774 1445 34915698
Syncope 17.47 13.80 50 39738 91401 34825742
Kidney enlargement 17.42 13.80 11 39777 781 34916362
Wheezing 17.40 13.80 13 39775 41389 34875754
Hypokinesia 17.36 13.80 34 39754 8846 34908297
Angina pectoris 17.30 13.80 7 39781 31356 34885787
Memory impairment 17.30 13.80 96 39692 43222 34873921
Hypoaesthesia 17.26 13.80 27 39761 61417 34855726
Haematoma 17.21 13.80 4 39784 25601 34891542
Chest pain 17.15 13.80 80 39708 126682 34790461
Product dose omission issue 17.13 13.80 74 39714 119637 34797506
Cerebral infarction 17.10 13.80 5 39783 27450 34889693
Stomatitis 17.04 13.80 14 39774 42500 34874643
Hallucination, olfactory 17.01 13.80 7 39781 199 34916944
Neoplasm progression 16.99 13.80 3 39785 23297 34893846
Foetal exposure during pregnancy 16.96 13.80 87 39701 38014 34879129
Polydipsia psychogenic 16.78 13.80 6 39782 115 34917028
Echocardiogram abnormal 16.74 13.80 12 39776 1051 34916092
Withdrawal syndrome 16.73 13.80 41 39747 12414 34904729
Libido increased 16.70 13.80 11 39777 840 34916303
Ascites 16.69 13.80 17 39771 46554 34870589
Thyroxine decreased 16.60 13.80 7 39781 212 34916931
Tri-iodothyronine decreased 16.55 13.80 6 39782 120 34917023
Hydrops foetalis 16.51 13.80 11 39777 856 34916287
Accidental death 16.49 13.80 17 39771 2439 34914704
Oromandibular dystonia 16.40 13.80 9 39779 492 34916651
Social anxiety disorder 16.40 13.80 8 39780 342 34916801
Hypertonia 16.18 13.80 22 39766 4224 34912919
International normalised ratio increased 16.15 13.80 18 39770 47309 34869834
Haematuria 16.06 13.80 20 39768 50046 34867097
Inappropriate affect 16.06 13.80 10 39778 693 34916450
Depressive symptom 16.05 13.80 18 39770 2841 34914302
Hallucination 16.04 13.80 107 39681 51391 34865752
Multiple organ dysfunction syndrome 16.03 13.80 40 39748 76526 34840617
Thought blocking 15.97 13.80 6 39782 133 34917010
Diabetic coma 15.95 13.80 11 39777 906 34916237
Platelet count decreased 15.94 13.80 76 39712 119641 34797502
Cerebral amyloid angiopathy 15.85 13.80 6 39782 136 34917007
Gastrooesophageal reflux disease 15.82 13.80 12 39776 37912 34879231
Oxygen saturation decreased 15.74 13.80 23 39765 53795 34863348
Dry skin 15.68 13.80 8 39780 31279 34885864
Dysphoria 15.57 13.80 16 39772 2286 34914857
Gastrectomy 15.45 13.80 6 39782 146 34916997
Globulins increased 15.39 13.80 8 39780 392 34916751
Toxic encephalopathy 15.35 13.80 24 39764 5225 34911918
Myalgia 15.33 13.80 47 39741 84063 34833080
Atrioventricular block first degree 15.30 13.80 26 39762 6066 34911077
Toxic cardiomyopathy 15.26 13.80 7 39781 260 34916883
Lymphocyte count increased 15.26 13.80 19 39769 3346 34913797
Chronic obstructive pulmonary disease 15.22 13.80 20 39768 48898 34868245
Hypersexuality 15.15 13.80 13 39775 1480 34915663
Muscle twitching 15.02 13.80 35 39753 10263 34906880
Acarodermatitis 15.00 13.80 8 39780 413 34916730
Metastases to eye 15.00 13.80 5 39783 77 34917066
Sinusitis 14.97 13.80 15 39773 41387 34875756
Weight 14.96 13.80 4 39784 27 34917116
Arthropathy 14.85 13.80 6 39782 26901 34890242
Intention tremor 14.79 13.80 8 39780 425 34916718
Long QT syndrome 14.64 13.80 17 39771 2786 34914357
Muscle contractions involuntary 14.59 13.80 14 39774 1842 34915301
Bradykinesia 14.58 13.80 20 39768 3873 34913270
Abdominal pain upper 14.46 13.80 38 39750 71452 34845691
Lung disorder 14.44 13.80 11 39777 34685 34882458
Cardiomyopathy 14.39 13.80 47 39741 16761 34900382
Nausea 14.30 13.80 287 39501 339621 34577522
Bronchitis 14.28 13.80 16 39772 41947 34875196
Psychomotor retardation 14.04 13.80 19 39769 3631 34913512
Hypothermia 14.03 13.80 35 39753 10713 34906430
Dysphagia 14.01 13.80 120 39668 62261 34854882
Feeling guilty 13.99 13.80 7 39781 316 34916827
Drug withdrawal syndrome 13.98 13.80 52 39736 19782 34897361
Hypoxia 13.84 13.80 26 39762 55069 34862074

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 2048.04 13.20 2267 75056 419273 79247792
Tremor 1270.28 13.20 1158 76165 168925 79498140
Antipsychotic drug level increased 1268.01 13.20 392 76931 5565 79661500
Neuroleptic malignant syndrome 1169.29 13.20 559 76764 27000 79640065
Nephrogenic diabetes insipidus 955.84 13.20 251 77072 1883 79665182
Mania 806.82 13.20 381 76942 17879 79649186
Drug interaction 798.47 13.20 1435 75888 413748 79253317
Extrapyramidal disorder 760.10 13.20 392 76931 22287 79644778
Agitation 466.24 13.20 528 76795 99187 79567878
Antipsychotic drug level above therapeutic 460.00 13.20 141 77182 1939 79665126
Hypomania 446.18 13.20 193 77130 7351 79659714
Ataxia 444.11 13.20 286 77037 24753 79642312
Psychotic disorder 412.21 13.20 333 76990 41069 79625996
Suicide attempt 411.42 13.20 453 76870 82479 79584586
Sopor 408.30 13.20 302 77021 32708 79634357
Parkinsonism 403.62 13.20 232 77091 16352 79650713
Confusional state 398.69 13.20 922 76401 317075 79349990
Serotonin syndrome 397.98 13.20 338 76985 44689 79622376
Hyperparathyroidism 384.13 13.20 137 77186 3087 79663978
Akathisia 373.01 13.20 204 77119 13055 79654010
Suicidal ideation 364.88 13.20 409 76914 75931 79591134
Dysarthria 364.51 13.20 386 76937 67236 79599829
Completed suicide 353.37 13.20 753 76570 245014 79422051
Schizophrenia 338.83 13.20 202 77121 15238 79651827
Sedation 319.07 13.20 318 77005 51577 79615488
Tardive dyskinesia 287.31 13.20 159 77164 10412 79656653
Salivary hypersecretion 278.51 13.20 173 77150 14051 79653014
Pain 277.86 13.20 170 77153 703632 78963433
Aggression 269.46 13.20 288 77035 50670 79616395
Dyspnoea 268.69 13.20 262 77061 856763 78810302
Muscle rigidity 266.49 13.20 191 77132 19691 79647374
Diabetes insipidus 261.51 13.20 119 77204 5118 79661947
Intentional self-injury 259.43 13.20 230 77093 32189 79634876
Psychomotor hyperactivity 258.86 13.20 176 77147 16673 79650392
Hypernatraemia 256.05 13.20 165 77158 14286 79652779
Overdose 256.04 13.20 557 76766 183649 79483416
Myoclonus 249.21 13.20 210 77113 27450 79639615
Arthralgia 245.93 13.20 124 77199 571679 79095386
Obsessive-compulsive disorder 244.43 13.20 118 77205 5809 79661256
Bipolar disorder 240.34 13.20 127 77196 7580 79659485
Somnolence 239.94 13.20 637 76686 238344 79428721
Granulocytopenia 239.03 13.20 145 77178 11286 79655779
Catatonia 236.04 13.20 131 77192 8625 79658440
Intentional overdose 220.26 13.20 380 76943 105580 79561485
Irritability 220.10 13.20 234 77089 40910 79626155
Hallucination, auditory 219.92 13.20 173 77150 20520 79646545
Drug abuse 204.79 13.20 473 76850 162218 79504847
Delusion 204.76 13.20 165 77158 20258 79646807
Delirium 199.28 13.20 321 77002 84306 79582759
Dyskinesia 188.83 13.20 225 77098 44548 79622517
Disorientation 185.95 13.20 265 77058 62511 79604554
Disturbance in attention 172.36 13.20 229 77094 50572 79616493
Antipsychotic drug level below therapeutic 164.26 13.20 57 77266 1181 79665884
Mental status changes 163.13 13.20 258 77065 66701 79600364
Infusion related reaction 162.75 13.20 17 77306 230220 79436845
Drug level increased 160.23 13.20 195 77128 39456 79627609
Coma 157.92 13.20 320 77003 100329 79566736
Polyuria 156.26 13.20 124 77199 14890 79652175
Rheumatoid arthritis 153.70 13.20 13 77310 208457 79458608
Altered state of consciousness 149.36 13.20 198 77125 43624 79623441
Cough 148.04 13.20 86 77237 366703 79300362
Hyperreflexia 146.72 13.20 95 77228 8290 79658775
Febrile neutropenia 144.42 13.20 25 77298 230974 79436091
Speech disorder 144.12 13.20 218 77105 54227 79612838
Restlessness 143.21 13.20 200 77123 46292 79620773
Dystonia 142.42 13.20 137 77186 21262 79645803
Joint swelling 140.70 13.20 52 77271 288594 79378471
Hypothyroidism 139.00 13.20 210 77113 52182 79614883
Depressed level of consciousness 138.41 13.20 296 77027 96356 79570709
Neurotoxicity 138.07 13.20 164 77159 32354 79634711
Electrocardiogram QT prolonged 136.62 13.20 283 77040 90103 79576962
Abnormal behaviour 135.74 13.20 172 77151 36249 79630816
Anaemia 133.34 13.20 141 77182 444874 79222191
Synovitis 131.63 13.20 3 77320 150731 79516334
Pruritus 131.08 13.20 114 77209 394534 79272531
Polydipsia 128.44 13.20 80 77243 6525 79660540
Bradyphrenia 126.27 13.20 95 77228 10545 79656520
Hypersensitivity 124.87 13.20 49 77274 262190 79404875
Euphoric mood 121.75 13.20 82 77241 7644 79659421
Peripheral swelling 119.42 13.20 56 77267 269561 79397504
Weight increased 118.73 13.20 558 76765 276828 79390237
Swelling 118.11 13.20 32 77291 216679 79450386
Schizoaffective disorder 117.32 13.20 52 77271 2100 79664965
Arthropathy 113.29 13.20 18 77305 177093 79489972
Pain in extremity 113.13 13.20 112 77211 364426 79302639
Disease progression 112.95 13.20 21 77302 184341 79482724
Pleurothotonus 112.61 13.20 53 77270 2463 79664602
Brugada syndrome 108.52 13.20 42 77281 1196 79665869
Back pain 108.27 13.20 82 77241 304098 79362967
Rash 107.84 13.20 252 77071 578106 79088959
Sinusitis 106.29 13.20 29 77294 195472 79471593
Blood creatine phosphokinase increased 105.86 13.20 212 77111 65878 79601187
Cerebellar syndrome 105.62 13.20 66 77257 5414 79661651
White blood cell count increased 100.48 13.20 223 77100 74410 79592655
Nasopharyngitis 100.29 13.20 61 77262 253820 79413245
Bruxism 99.75 13.20 57 77266 3969 79663096
Fatigue 99.70 13.20 514 76809 929213 78737852
Malignant neoplasm progression 98.80 13.20 9 77314 135981 79531084
Treatment noncompliance 97.66 13.20 179 77144 52089 79614976
Cognitive disorder 97.61 13.20 212 77111 69714 79597351
Leukocytosis 97.05 13.20 161 77162 43294 79623771
Systemic lupus erythematosus 96.77 13.20 5 77318 121144 79545921
Alopecia 96.51 13.20 52 77271 231303 79435762
Apathy 95.78 13.20 88 77235 12889 79654176
Logorrhoea 95.47 13.20 57 77266 4308 79662757
Body tinea 95.32 13.20 43 77280 1811 79665254
Nephropathy 94.06 13.20 77 77246 9661 79657404
Neutrophil count increased 92.82 13.20 128 77195 29268 79637797
Drug intolerance 90.44 13.20 74 77249 264045 79403020
Encephalopathy 90.30 13.20 201 77122 67196 79599869
Depression 88.99 13.20 431 76892 216359 79450706
Depressed mood 88.02 13.20 164 77159 48316 79618749
Hand deformity 87.28 13.20 3 77320 103916 79563149
Death 85.23 13.20 274 77049 566240 79100825
Priapism 83.67 13.20 53 77270 4452 79662613
Infection 83.66 13.20 67 77256 241645 79425420
Stomatitis 83.15 13.20 20 77303 146737 79520328
Bradykinesia 82.78 13.20 66 77257 7977 79659088
Camptocormia 82.67 13.20 27 77296 461 79666604
Atrial fibrillation 81.76 13.20 45 77278 197841 79469224
Grandiosity 81.66 13.20 28 77295 559 79666506
Disinhibition 81.53 13.20 43 77280 2555 79664510
Contraindicated product administered 80.82 13.20 26 77297 157512 79509553
Increased appetite 80.29 13.20 77 77246 11901 79655164
Glossodynia 80.27 13.20 5 77318 103332 79563733
Cogwheel rigidity 79.95 13.20 45 77278 3043 79664022
Arthritis 79.82 13.20 9 77314 114871 79552194
Mutism 79.42 13.20 41 77282 2331 79664734
Pneumonia 79.40 13.20 350 76973 659896 79007169
Enuresis 78.78 13.20 45 77278 3131 79663934
Intentional product use issue 78.22 13.20 25 77298 152087 79514978
Pericarditis 78.19 13.20 6 77317 104230 79562835
Oppositional defiant disorder 78.18 13.20 26 77297 471 79666594
Anxiety 78.05 13.20 459 76864 248053 79419012
Coordination abnormal 77.95 13.20 90 77233 17222 79649843
Interstitial lung disease 77.78 13.20 9 77314 112591 79554474
Hypercalcaemia 77.40 13.20 136 77187 38294 79628771
Libido increased 76.99 13.20 38 77285 1963 79665102
Renal cyst 75.61 13.20 82 77241 14650 79652415
Mental disorder 75.36 13.20 120 77203 31182 79635883
Homicidal ideation 75.23 13.20 45 77278 3412 79663653
Clonus 74.42 13.20 58 77265 6782 79660283
Abdominal discomfort 74.37 13.20 80 77243 250647 79416418
Wound 73.84 13.20 12 77311 116167 79550898
Poor quality sleep 73.34 13.20 100 77223 22622 79644443
Choreoathetosis 73.14 13.20 34 77289 1536 79665529
Affect lability 72.88 13.20 71 77252 11188 79655877
Paranoia 72.76 13.20 92 77231 19340 79647725
Jaundice cholestatic 72.74 13.20 71 77252 11213 79655852
Headache 72.44 13.20 357 76966 653415 79013650
Withdrawal syndrome 71.72 13.20 108 77215 26746 79640319
Aphasia 71.38 13.20 147 77176 46585 79620480
Urticaria 69.69 13.20 47 77276 185154 79481911
Poisoning 69.44 13.20 103 77220 25169 79641896
Parathyroid tumour benign 69.01 13.20 27 77296 792 79666273
Cardiac failure congestive 68.75 13.20 26 77297 142376 79524689
Glucose tolerance impaired 67.95 13.20 59 77264 8025 79659040
Electroencephalogram abnormal 67.79 13.20 50 77273 5384 79661681
Infection susceptibility increased 67.17 13.20 43 77280 3678 79663387
Inhibitory drug interaction 67.16 13.20 46 77277 4407 79662658
Poisoning deliberate 67.13 13.20 87 77236 18741 79648324
Insomnia 66.43 13.20 436 76887 244734 79422331
Hyperprolactinaemia 65.13 13.20 46 77277 4630 79662435
Gastrointestinal haemorrhage 64.87 13.20 31 77292 147688 79519377
Decreased eye contact 64.13 13.20 26 77297 839 79666226
Hyperparathyroidism primary 64.07 13.20 22 77301 441 79666624
Drooling 63.87 13.20 50 77273 5884 79661181
Stupor 63.58 13.20 53 77270 6819 79660246
Pyramidal tract syndrome 62.27 13.20 23 77300 574 79666491
General physical health deterioration 62.25 13.20 107 77216 275131 79391934
Hyperthermia 62.22 13.20 82 77241 17955 79649110
Thinking abnormal 61.93 13.20 70 77253 13091 79653974
Leukopenia 61.67 13.20 250 77073 116263 79550802
Acute kidney injury 60.99 13.20 770 76553 518634 79148431
Abdominal pain 60.92 13.20 185 77138 389384 79277681
Bipolar I disorder 60.54 13.20 33 77290 2096 79664969
Chronic kidney disease 59.91 13.20 170 77153 65984 79601081
Diarrhoea 59.45 13.20 557 76766 879932 78787133
Blister 59.04 13.20 21 77302 119455 79547610
Sepsis 58.89 13.20 107 77216 269321 79397744
Therapeutic product effect decreased 58.48 13.20 44 77279 163819 79503246
Drug level above therapeutic 58.33 13.20 56 77267 8667 79658398
Hostility 58.02 13.20 33 77290 2277 79664788
Psychiatric decompensation 57.56 13.20 40 77283 3923 79663142
Gait disturbance 57.40 13.20 371 76952 207135 79459930
Hypothermia 57.25 13.20 89 77234 22657 79644408
Asthma 56.84 13.20 30 77293 135065 79532000
Postural tremor 56.82 13.20 23 77300 739 79666326
Treatment failure 56.81 13.20 49 77274 170437 79496628
Thrombocytopenia 56.51 13.20 107 77216 265152 79401913
Drug reaction with eosinophilia and systemic symptoms 56.15 13.20 163 77160 64081 79602984
Impaired healing 55.82 13.20 9 77314 87646 79579419
Neuropathy peripheral 55.70 13.20 34 77289 141271 79525794
Abdominal pain upper 55.33 13.20 82 77241 223737 79443328
Chest pain 54.93 13.20 120 77203 282184 79384881
Myocarditis 54.65 13.20 85 77238 21648 79645417
Lethargy 54.32 13.20 188 77135 81104 79585961
Anger 53.09 13.20 74 77249 17088 79649977
Cardio-respiratory arrest 52.09 13.20 226 77097 108284 79558781
Hypertonia 51.35 13.20 48 77275 7184 79659881
Bronchitis 50.71 13.20 32 77291 130612 79536453
Abulia 50.36 13.20 23 77300 997 79666068
Blood prolactin increased 50.25 13.20 37 77286 3974 79663091
Psoriatic arthropathy 49.69 13.20 8 77315 77991 79589074
Pressure of speech 49.28 13.20 24 77299 1204 79665861
Urinary incontinence 49.26 13.20 117 77206 40792 79626273
Dystonic tremor 49.08 13.20 15 77308 204 79666861
Gestational diabetes 49.04 13.20 44 77279 6249 79660816
Galactorrhoea 48.78 13.20 35 77288 3611 79663454
Blood sodium increased 48.58 13.20 39 77284 4759 79662306
Hypokinesia 48.56 13.20 75 77248 18985 79648080
Myocardial infarction 47.95 13.20 65 77258 184064 79483001
Persecutory delusion 47.80 13.20 39 77284 4870 79662195
Musculoskeletal pain 47.25 13.20 20 77303 102334 79564731
Mental impairment 47.23 13.20 74 77249 18962 79648103
Distractibility 47.14 13.20 20 77303 725 79666340
Anticholinergic syndrome 46.80 13.20 34 77289 3577 79663488
Psychiatric symptom 46.73 13.20 45 77278 6990 79660075
Persistent depressive disorder 46.71 13.20 23 77300 1182 79665883
Drug hypersensitivity 46.66 13.20 142 77181 298774 79368291
Bundle branch block right 46.52 13.20 56 77267 11195 79655870
Depressive symptom 46.32 13.20 43 77280 6380 79660685
Tachycardia 45.63 13.20 312 77011 177456 79489609
Injection site erythema 45.59 13.20 10 77313 78187 79588878
Mucosal inflammation 45.44 13.20 9 77314 75571 79591494
Ascites 45.42 13.20 9 77314 75553 79591512
Electroconvulsive therapy 45.11 13.20 12 77311 95 79666970
Behaviour disorder 45.02 13.20 42 77281 6271 79660794
COVID-19 44.87 13.20 52 77271 157622 79509443
Pancytopenia 44.70 13.20 57 77266 165688 79501377
Mobility decreased 44.63 13.20 32 77291 122143 79544922
Productive cough 44.55 13.20 15 77308 88316 79578749
Self-injurious ideation 44.32 13.20 33 77290 3605 79663460
Balance disorder 43.76 13.20 201 77122 98656 79568409
Osteoarthritis 43.73 13.20 15 77308 87294 79579771
Muscle contractions involuntary 43.31 13.20 33 77290 3732 79663333
Renal oncocytoma 43.05 13.20 11 77312 73 79666992
Metabolic syndrome 42.98 13.20 29 77294 2711 79664354
Off label use 42.87 13.20 621 76702 906594 78760471
Muscle twitching 42.74 13.20 82 77241 24682 79642383
Fibromyalgia 42.36 13.20 6 77317 64334 79602731
Trismus 42.16 13.20 38 77285 5429 79661636
Action tremor 42.14 13.20 16 77307 432 79666633
Resting tremor 41.66 13.20 23 77300 1498 79665567
Hallucination 41.47 13.20 179 77144 85566 79581499
Electrocardiogram T wave abnormal 41.33 13.20 32 77291 3706 79663359
Mood altered 41.02 13.20 67 77256 17780 79649285
Therapeutic product effect variable 40.75 13.20 25 77298 1984 79665081
Blunted affect 40.53 13.20 16 77307 481 79666584
Haemodialysis 40.14 13.20 67 77256 18101 79648964
Gastrointestinal disorder 39.65 13.20 36 77287 122169 79544896
Discomfort 39.59 13.20 38 77285 125579 79541486
Apraxia 39.46 13.20 28 77295 2839 79664226
Paraesthesia 39.43 13.20 69 77254 176254 79490811
Major depression 39.28 13.20 46 77277 8934 79658131
Malaise 39.21 13.20 296 77027 489573 79177492
Sexually inappropriate behaviour 39.10 13.20 16 77307 529 79666536
Visuospatial deficit 39.01 13.20 9 77314 36 79667029
Feelings of worthlessness 38.90 13.20 16 77307 536 79666529
Electrocardiogram T wave inversion 38.81 13.20 36 77287 5336 79661729
Oculogyric crisis 38.72 13.20 28 77295 2924 79664141
Cerebellar atrophy 38.67 13.20 20 77303 1141 79665924
Asterixis 38.56 13.20 27 77296 2680 79664385
Oedema peripheral 38.55 13.20 121 77202 252167 79414898
Lower respiratory tract infection 38.54 13.20 41 77282 129179 79537886
International normalised ratio increased 38.40 13.20 17 77306 84704 79582361
Lung disorder 38.39 13.20 15 77308 80542 79586523
Wheezing 38.29 13.20 34 77289 116630 79550435
Pleural effusion 38.09 13.20 51 77272 145211 79521854
Urinary retention 37.85 13.20 131 77192 56499 79610566
Failure to suspend medication 37.74 13.20 15 77308 459 79666606
Miosis 37.27 13.20 60 77263 15729 79651336
Haemorrhage 37.21 13.20 21 77302 91097 79575968
Agranulocytosis 37.20 13.20 112 77211 44918 79622147
Melaena 37.13 13.20 7 77316 60883 79606182
Pneumonitis 37.11 13.20 7 77316 60853 79606212
Product use issue 36.95 13.20 94 77229 209728 79457337
Language disorder 36.60 13.20 28 77295 3186 79663879
Personality disorder 36.53 13.20 37 77286 6109 79660956
Restless legs syndrome 36.50 13.20 68 77255 20024 79647041
Blood pressure fluctuation 36.39 13.20 10 77313 67135 79599930
Cerebrovascular accident 36.35 13.20 59 77264 155233 79511832
Anaphylactic reaction 36.11 13.20 18 77305 83725 79583340
Psychomotor skills impaired 35.73 13.20 34 77289 5203 79661862
Soft tissue injury 35.71 13.20 22 77301 1759 79665306
Long QT syndrome 35.67 13.20 36 77287 5919 79661146
Septic shock 35.48 13.20 40 77283 122761 79544304
Schizoaffective disorder bipolar type 35.45 13.20 12 77311 230 79666835
Neutrophilia 35.23 13.20 41 77282 7910 79659155
Cardiac failure 35.16 13.20 60 77263 154782 79512283
Feeling guilty 34.94 13.20 17 77306 851 79666214
Sleep-related eating disorder 34.94 13.20 16 77307 698 79666367
Rhinorrhoea 34.89 13.20 15 77308 76059 79591006
Antipsychotic drug level decreased 34.88 13.20 19 77304 1205 79665860
Epistaxis 34.83 13.20 34 77289 111481 79555584
Delusion of grandeur 34.74 13.20 20 77303 1412 79665653
Electrocardiogram abnormal 34.70 13.20 60 77263 16677 79650388
Impulsive behaviour 34.65 13.20 26 77297 2874 79664191
Sinus bradycardia 34.60 13.20 76 77247 25171 79641894
Nausea 34.53 13.20 688 76635 956508 78710557
Psychomotor retardation 34.53 13.20 36 77287 6148 79660917
Hypomagnesaemia 34.34 13.20 3 77320 46908 79620157
Social avoidant behaviour 34.27 13.20 32 77291 4782 79662283
Dyspnoea exertional 34.24 13.20 21 77302 87052 79580013
Muscle spasms 34.19 13.20 74 77249 174656 79492409
Goitre 34.12 13.20 34 77289 5505 79661560
Acute psychosis 34.11 13.20 30 77293 4150 79662915
Hyperthyroidism 34.07 13.20 70 77253 22139 79644926
Acute myocardial infarction 34.07 13.20 16 77307 77020 79590045
Electrocardiogram QRS complex prolonged 33.94 13.20 47 77276 10786 79656279
Decreased appetite 33.90 13.20 194 77129 342224 79324841
Hyperkinesia 33.79 13.20 25 77298 2704 79664361
Injection site pain 33.62 13.20 46 77277 129792 79537273
Neoplasm progression 33.60 13.20 5 77318 51677 79615388
Erythema 33.47 13.20 108 77215 223182 79443883
Blood thyroid stimulating hormone decreased 33.22 13.20 34 77289 5682 79661383
Otospondylomegaepiphyseal dysplasia 33.06 13.20 8 77315 41 79667024
Nodal rhythm 32.85 13.20 26 77297 3109 79663956
Sluggishness 32.71 13.20 36 77287 6536 79660529
Platelet count decreased 32.16 13.20 90 77233 194574 79472491
Adams-Stokes syndrome 32.00 13.20 10 77313 147 79666918
Toxic encephalopathy 31.96 13.20 47 77276 11393 79655672
Patient restraint 31.44 13.20 9 77314 96 79666969
Speech sound disorder 31.32 13.20 8 77315 53 79667012
Hypoaesthesia 31.07 13.20 81 77242 179271 79487794
Protein C increased 30.95 13.20 9 77314 102 79666963
Plasma cell myeloma 30.67 13.20 7 77316 53252 79613813
Influenza 30.56 13.20 49 77274 129557 79537508
Status epilepticus 30.56 13.20 72 77251 24969 79642096
Hallucination, olfactory 30.55 13.20 13 77310 475 79666590
Oncocytoma 30.54 13.20 7 77316 27 79667038
Dysphemia 30.44 13.20 26 77297 3458 79663607
Seizure 30.33 13.20 298 77025 188536 79478529
Differential white blood cell count abnormal 30.25 13.20 21 77302 2056 79665009
Drug withdrawal syndrome 30.24 13.20 88 77235 34630 79632435
Tachyphrenia 30.22 13.20 21 77302 2059 79665006
Injection site pruritus 30.16 13.20 3 77320 42280 79624785
Echolalia 30.11 13.20 12 77311 370 79666695
Post-traumatic neck syndrome 30.10 13.20 21 77302 2073 79664992
Respiratory arrest 30.05 13.20 123 77200 57427 79609638
Inflammation 29.96 13.20 28 77295 93725 79573340
Hyporeflexia 29.90 13.20 26 77297 3542 79663523
Upper respiratory tract infection 29.40 13.20 27 77296 91141 79575924
Upper gastrointestinal haemorrhage 29.35 13.20 3 77320 41377 79625688
Memory impairment 29.18 13.20 197 77126 111537 79555528
Metabolic encephalopathy 29.13 13.20 40 77283 9107 79657958
Chest discomfort 29.09 13.20 56 77267 137988 79529077
Dysphoria 29.05 13.20 29 77294 4705 79662360
Nephropathy toxic 28.58 13.20 62 77261 20357 79646708
Antipsychotic drug level 28.43 13.20 6 77317 14 79667051
Gambling disorder 28.38 13.20 20 77303 2006 79665059
Coronary artery disease 28.34 13.20 14 77309 65460 79601605
Hyperhidrosis 28.32 13.20 247 77076 151245 79515820
Papillary thyroid cancer 28.29 13.20 22 77301 2564 79664501
Nystagmus 28.12 13.20 41 77282 9863 79657202
Poverty of speech 28.09 13.20 13 77310 581 79666484
Blood creatinine increased 28.05 13.20 251 77072 154806 79512259
Haematoma 27.86 13.20 8 77315 52187 79614878
Convulsive threshold lowered 27.82 13.20 15 77308 932 79666133
Parkinsonian gait 27.81 13.20 15 77308 933 79666132
Skin ulcer 27.65 13.20 9 77314 54141 79612924
Affective disorder 27.43 13.20 37 77286 8282 79658783
Hypoxia 27.32 13.20 36 77287 103207 79563858
Bone pain 27.19 13.20 10 77313 55732 79611333
Blood pressure increased 27.18 13.20 109 77214 211251 79455814
Thrombosis 27.01 13.20 25 77298 84075 79582990
Impaired work ability 26.69 13.20 59 77264 19622 79647443
Oxygen saturation decreased 26.63 13.20 53 77270 128994 79538071
Movement disorder 26.60 13.20 72 77251 27187 79639878
Sternal fracture 26.55 13.20 21 77302 2509 79664556
Knee arthroplasty 26.31 13.20 5 77318 43243 79623822
Osteonecrosis of jaw 26.29 13.20 5 77318 43221 79623844
Deprescribing error 26.21 13.20 6 77317 23 79667042
Hyperammonaemia 25.97 13.20 42 77281 11051 79656014
Hyperleukocytosis 25.97 13.20 21 77302 2589 79664476
Myelosuppression 25.96 13.20 4 77319 40292 79626773
Haematochezia 25.92 13.20 28 77295 87617 79579448
Haemoptysis 25.75 13.20 11 77312 55988 79611077
Hallucination, visual 25.72 13.20 80 77243 32649 79634416
Angina pectoris 25.71 13.20 9 77314 51723 79615342
Sinus arrest 25.64 13.20 24 77299 3598 79663467
Injection site swelling 25.58 13.20 7 77316 47125 79619940
Induced abortion failed 25.47 13.20 9 77314 197 79666868
Hereditary ataxia 25.44 13.20 6 77317 27 79667038
Gaze palsy 25.39 13.20 22 77301 2983 79664082
Acquired cystic kidney disease 25.14 13.20 7 77316 67 79666998
Reflexes abnormal 25.12 13.20 14 77309 929 79666136
Antidepressant drug level increased 24.89 13.20 11 77312 441 79666624
Substance abuse 24.85 13.20 40 77283 10486 79656579
Diverticulitis 24.60 13.20 7 77316 45929 79621136
Fluid retention 24.57 13.20 19 77304 69790 79597275
Dyslipidaemia 24.50 13.20 42 77281 11591 79655474
Hypersexuality 24.50 13.20 17 77306 1663 79665402
Staphylococcal infection 24.43 13.20 13 77310 58282 79608783
Maternal exposure during pregnancy 24.16 13.20 61 77262 136477 79530588
Impaired quality of life 24.05 13.20 47 77276 14339 79652726
Bone density decreased 24.03 13.20 45 77278 13302 79653763
Myocarditis septic 24.00 13.20 6 77317 36 79667029
Flat affect 23.72 13.20 18 77305 2023 79665042
Crying 23.63 13.20 62 77261 22981 79644084
Chronic obstructive pulmonary disease 23.41 13.20 29 77294 85390 79581675
Dry skin 23.31 13.20 19 77304 67976 79599089
Ideas of reference 23.22 13.20 8 77315 162 79666903
Ear infection 23.16 13.20 3 77320 34429 79632636
Irritable bowel syndrome 23.12 13.20 16 77307 62225 79604840
Blood thyroid stimulating hormone increased 23.06 13.20 37 77286 9671 79657394
Mood swings 23.01 13.20 56 77267 19824 79647241
Neurological symptom 22.99 13.20 35 77288 8748 79658317
Haemoglobin decreased 22.97 13.20 124 77199 221995 79445070
Conversion disorder 22.94 13.20 17 77306 1844 79665221
Weight decreased 22.87 13.20 227 77096 354971 79312094
Cerebral haemorrhage 22.55 13.20 14 77309 57659 79609406
Cerebellar ataxia 22.46 13.20 17 77306 1904 79665161
Injection site bruising 22.42 13.20 6 77317 40996 79626069
Throat irritation 22.37 13.20 6 77317 40940 79626125
Water intoxication 22.01 13.20 12 77311 762 79666303
Ill-defined disorder 21.85 13.20 19 77304 65856 79601209
Sexual dysfunction 21.84 13.20 32 77291 7731 79659334
Mydriasis 21.82 13.20 51 77272 17592 79649473
Bradycardia 21.79 13.20 214 77109 135343 79531722
Osteomyelitis 21.78 13.20 3 77320 32862 79634203
Cystitis 21.75 13.20 12 77311 52720 79614345
Hallucinations, mixed 21.71 13.20 30 77293 6869 79660196
Oropharyngeal pain 21.64 13.20 46 77277 109307 79557758
Localised infection 21.51 13.20 5 77318 37570 79629495
Gastric disorder 21.39 13.20 5 77318 37428 79629637
Dialysis 21.36 13.20 52 77271 18410 79648655
Progressive supranuclear palsy 21.35 13.20 7 77316 121 79666944
Clostridium difficile colitis 21.27 13.20 3 77320 32280 79634785
Cholelithiasis 21.06 13.20 104 77219 52560 79614505
Electric shock sensation 20.85 13.20 12 77311 847 79666218
Rectal haemorrhage 20.81 13.20 26 77297 76274 79590791
Flight of ideas 20.81 13.20 12 77311 850 79666215
Negativism 20.80 13.20 12 77311 851 79666214
Rhabdomyolysis 20.77 13.20 171 77152 102960 79564105
Encopresis 20.74 13.20 7 77316 133 79666932
Hyperlipidaemia 20.71 13.20 64 77259 26029 79641036
High-grade B-cell lymphoma 20.64 13.20 7 77316 135 79666930
Ileus paralytic 20.61 13.20 35 77288 9585 79657480
Sleep disorder 20.57 13.20 148 77175 85529 79581536
Thought blocking 20.53 13.20 8 77315 232 79666833
Product dose omission issue 20.52 13.20 148 77175 247389 79419676
Purpura 20.50 13.20 53 77270 19474 79647591
Medication error 20.36 13.20 125 77198 68517 79598548
Haematuria 20.34 13.20 22 77301 68814 79598251
Delusion of reference 20.08 13.20 7 77316 147 79666918
Clear cell renal cell carcinoma 20.05 13.20 18 77305 2558 79664507
Hypokalaemia 19.99 13.20 72 77251 143968 79523097
Abdominal distension 19.99 13.20 55 77268 119595 79547470
Prostate cancer 19.91 13.20 4 77319 33264 79633801
Atrioventricular block first degree 19.91 13.20 40 77283 12451 79654614
Sciatica 19.87 13.20 4 77319 33218 79633847
Lactate pyruvate ratio increased 19.81 13.20 6 77317 79 79666986
Merycism 19.79 13.20 8 77315 256 79666809
Dysphagia 19.72 13.20 193 77130 121943 79545122
Decreased interest 19.71 13.20 21 77302 3676 79663389
Intention tremor 19.66 13.20 11 77312 735 79666330
Muscle contracture 19.65 13.20 17 77306 2300 79664765
International normalised ratio abnormal 19.55 13.20 26 77297 5742 79661323
Bacteraemia 19.54 13.20 4 77319 32820 79634245
Cerebral atrophy 19.49 13.20 31 77292 8044 79659021
Eosinophil count decreased 19.37 13.20 20 77303 3376 79663689
Drug level decreased 19.33 13.20 43 77280 14359 79652706
Torticollis 19.21 13.20 17 77306 2370 79664695
Lactic acidosis 19.16 13.20 24 77299 70335 79596730
Autonomic nervous system imbalance 19.07 13.20 23 77300 4607 79662458
Diabetic coma 19.05 13.20 13 77310 1238 79665827
Myalgia 18.99 13.20 104 77219 185537 79481528
Thyrotoxic crisis 18.74 13.20 13 77310 1271 79665794
Osteoporosis 18.70 13.20 15 77308 54097 79612968
Angioedema 18.63 13.20 28 77295 76007 79591058
Choking 18.39 13.20 38 77285 12063 79655002
Suspected suicide 18.23 13.20 35 77288 10541 79656524
Blood pressure systolic increased 18.09 13.20 23 77300 66963 79600102
Oscillopsia 18.03 13.20 7 77316 201 79666864
Histrionic personality disorder 17.94 13.20 5 77318 48 79667017
Incoherent 17.84 13.20 29 77294 7663 79659402
Generalised tonic-clonic seizure 17.76 13.20 87 77236 43823 79623242
Irregular sleep wake rhythm disorder 17.62 13.20 8 77315 342 79666723
Thyroiditis 17.55 13.20 22 77301 4583 79662482
Secondary tic 17.54 13.20 4 77319 15 79667050
Obesity 17.49 13.20 74 77249 35051 79632014
Hepatic cirrhosis 17.47 13.20 6 77317 34900 79632165
Psoriasis 17.46 13.20 38 77285 89549 79577516
Urinary tract infection 17.42 13.20 176 77147 274336 79392729
Unmasking of previously unidentified disease 17.26 13.20 15 77308 2042 79665023
Megacolon 17.15 13.20 19 77304 3476 79663589
Femur fracture 17.13 13.20 8 77315 38644 79628421
Sinus tachycardia 17.04 13.20 76 77247 36832 79630233
Blood citric acid increased 17.01 13.20 5 77318 59 79667006
Mouth ulceration 16.93 13.20 8 77315 38386 79628679
Nephrolithiasis 16.92 13.20 16 77307 53275 79613790
Pulmonary oedema 16.74 13.20 38 77285 88216 79578849
Social anxiety disorder 16.65 13.20 9 77314 562 79666503
Bursitis 16.54 13.20 7 77316 35837 79631228
Blood urea increased 16.51 13.20 92 77231 48698 79618367
Fungal infection 16.50 13.20 10 77313 41738 79625327
Obstructive airways disorder 16.47 13.20 5 77318 31454 79635611
Compulsions 16.45 13.20 8 77315 400 79666665
Diabetic hyperosmolar coma 16.38 13.20 10 77313 787 79666278
Therapy interrupted 16.37 13.20 5 77318 31336 79635729
Pulmonary mass 16.35 13.20 4 77319 29030 79638035
Osteonecrosis 16.17 13.20 5 77318 31090 79635975
Blood triglycerides increased 16.14 13.20 51 77272 20989 79646076
Urine output increased 16.07 13.20 15 77308 2241 79664824
Body mass index increased 16.03 13.20 14 77309 1919 79665146
Prescribed overdose 16 13.20 76 77247 37807 79629258
Activation syndrome 15.90 13.20 7 77316 278 79666787
Hip fracture 15.90 13.20 5 77318 30756 79636309
Staring 15.86 13.20 16 77307 2629 79664436
Flatulence 15.85 13.20 11 77312 42713 79624352
Dry eye 15.82 13.20 8 77315 36923 79630142
Clostridium difficile infection 15.82 13.20 11 77312 42674 79624391
Psychotic disorder due to a general medical condition 15.76 13.20 7 77316 284 79666781
Colitis ulcerative 15.69 13.20 7 77316 34735 79632330
Pain in jaw 15.69 13.20 13 77310 46138 79620927
Psychotic symptom 15.60 13.20 16 77307 2681 79664384
Full blood count abnormal 15.58 13.20 10 77313 40464 79626601
Limbic encephalitis 15.52 13.20 10 77313 865 79666200
Tri-iodothyronine decreased 15.51 13.20 7 77316 295 79666770
Injection site haemorrhage 15.39 13.20 4 77319 27866 79639199
Metabolic disorder 15.38 13.20 30 77293 9140 79657925
Hyperammonaemic encephalopathy 15.36 13.20 21 77302 4761 79662304
Thyroid function test abnormal 15.31 13.20 17 77306 3117 79663948
Antidepressant drug level above therapeutic 15.23 13.20 9 77314 667 79666398
Eosinophilia 15.01 13.20 85 77238 45260 79621805
Potentiating drug interaction 14.97 13.20 29 77294 8790 79658275
Small intestinal obstruction 14.89 13.20 4 77319 27268 79639797
Illness 14.73 13.20 14 77309 46497 79620568
Basal cell carcinoma 14.71 13.20 9 77314 37366 79629699
Non-high-density lipoprotein cholesterol increased 14.70 13.20 7 77316 334 79666731
Refusal of treatment by patient 14.58 13.20 29 77294 8962 79658103
Excessive masturbation 14.57 13.20 5 77318 100 79666965
Hepatic failure 14.56 13.20 23 77300 61189 79605876
Polydipsia psychogenic 14.39 13.20 6 77317 208 79666857
Electrocardiogram T wave amplitude decreased 14.37 13.20 9 77314 741 79666324
Cyclothymic disorder 14.29 13.20 6 77317 212 79666853
Hepatotoxicity 14.29 13.20 92 77231 51260 79615805
Tic 14.25 13.20 16 77307 2970 79664095
Autoimmune thyroiditis 14.22 13.20 19 77304 4214 79662851
Weight 14.12 13.20 4 77319 41 79667024
Parasomnia 14.05 13.20 8 77315 553 79666512
Night sweats 13.95 13.20 18 77305 52077 79614988
Cardiac hypertrophy 13.91 13.20 12 77311 1618 79665447
Device related infection 13.86 13.20 8 77315 34286 79632779
Sleep apnoea syndrome 13.85 13.20 71 77252 36407 79630658
Consciousness fluctuating 13.85 13.20 13 77310 1956 79665109
Impaired self-care 13.77 13.20 15 77308 2692 79664373
Loss of personal independence in daily activities 13.75 13.20 52 77271 102528 79564537
Food craving 13.74 13.20 12 77311 1645 79665420
Coagulopathy 13.72 13.20 9 77314 35997 79631068
Anaphylactic shock 13.71 13.20 9 77314 35987 79631078
Nasal congestion 13.69 13.20 34 77289 76518 79590547
Fluid intake reduced 13.64 13.20 23 77300 6265 79660800
Tension 13.63 13.20 19 77304 4385 79662680
Left atrial dilatation 13.54 13.20 16 77307 3137 79663928
Lung neoplasm malignant 13.53 13.20 5 77318 27787 79639278
Neoplasm malignant 13.47 13.20 7 77316 31803 79635262
Oral pain 13.46 13.20 7 77316 31791 79635274
Toxic cardiomyopathy 13.38 13.20 7 77316 409 79666656
Oedema 13.35 13.20 65 77258 119515 79547550
Frequent bowel movements 13.27 13.20 6 77317 29533 79637532

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05AN01 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Lithium
CHEBI has role CHEBI:35477 antimanic drugs
MeSH PA D000928 Antidepressive Agents
MeSH PA D018692 Antimanic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Bipolar disorder indication 13746004 DOID:3312
Pain indication 22253000
Rheumatoid arthritis indication 69896004 DOID:7148
Bipolar disorder in remission indication 85248005
Bipolar affective disorder, current episode manic indication 191618007
Headache disorder indication 230461009
Dysmenorrhea indication 266599000
Fever indication 386661006
Osteoarthritis indication 396275006
Juvenile rheumatoid arthritis indication 410795001
Vascular headache off-label use 128187005
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Cluster Headache Prevention off-label use
Rapid Cycling Bipolar Affective Disorder off-label use
Psoriasis contraindication 9014002 DOID:8893
Diabetes insipidus contraindication 15771004 DOID:9409
Polyuria contraindication 28442001
Hypothyroidism contraindication 40930008 DOID:1459
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Acute infectious disease contraindication 63171007
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Organic mental disorder contraindication 111479008
Plaque psoriasis contraindication 200965009
Pregnancy, function contraindication 289908002
Breastfeeding (mother) contraindication 413712001
Severe dehydration contraindication 450316000
Lithium Toxicity contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glycogen synthase kinase-3 Kinase INHIBITOR CHEMBL CHEMBL
Inositol-1(or 4)-monophosphatase 1 Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
4018007 VUID
N0000146351 NUI
D00801 KEGG_DRUG
4018007 VANDF
4019803 VANDF
C0085217 UMLSCUI
CHEBI:6504 CHEBI
CHEBI:30145 CHEBI
CHEMBL1200826 ChEMBL_ID
D016651 MESH_DESCRIPTOR_UI
DB14509 DRUGBANK_ID
2BMD2GNA4V UNII
11125 PUBCHEM_CID
42351 RXNORM
1990 MMSL
4986 MMSL
d00061 MMSL
001532 NDDF
001533 NDDF
16977003 SNOMEDCT_US
321719003 SNOMEDCT_US
387095003 SNOMEDCT_US
85899009 SNOMEDCT_US
C0023870 UMLSCUI
CHEMBL2146126 ChEMBL_ID
7439-93-2 SECONDARY_CAS_RN
3028194 PUBCHEM_CID
D008094 MESH_DESCRIPTOR_UI
9FN79X2M3F UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0020 TABLET, EXTENDED RELEASE 450 mg ORAL ANDA 16 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0020 TABLET, EXTENDED RELEASE 450 mg ORAL ANDA 16 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0020 TABLET, EXTENDED RELEASE 450 mg ORAL ANDA 16 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0021 TABLET, EXTENDED RELEASE 300 mg ORAL ANDA 13 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0021 TABLET, EXTENDED RELEASE 300 mg ORAL ANDA 13 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0021 TABLET, EXTENDED RELEASE 300 mg ORAL ANDA 13 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-2526 CAPSULE, GELATIN COATED 150 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-2526 CAPSULE, GELATIN COATED 150 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-2526 CAPSULE, GELATIN COATED 150 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-2527 CAPSULE, GELATIN COATED 300 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-2527 CAPSULE, GELATIN COATED 300 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-2527 CAPSULE, GELATIN COATED 300 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-2531 CAPSULE, GELATIN COATED 600 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-2531 CAPSULE, GELATIN COATED 600 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-2531 CAPSULE, GELATIN COATED 600 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-4527 TABLET 300 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-4527 TABLET 300 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-4527 TABLET 300 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-8526 CAPSULE, GELATIN COATED 150 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-8526 CAPSULE, GELATIN COATED 150 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-8526 CAPSULE, GELATIN COATED 150 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-8527 CAPSULE, GELATIN COATED 300 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-8527 CAPSULE, GELATIN COATED 300 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-8527 CAPSULE, GELATIN COATED 300 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-8528 TABLET 300 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-8528 TABLET 300 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-8528 TABLET 300 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-8531 CAPSULE, GELATIN COATED 600 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-8531 CAPSULE, GELATIN COATED 600 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-8531 CAPSULE, GELATIN COATED 600 mg ORAL NDA 26 sections