| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4207 | 554-13-2 |
| Molecule | Description |
|---|---|
|
Synonyms:
|
A lithium salt, classified as a mood-stabilizing agent. Lithium ion alters the metabolism of BIOGENIC MONOAMINES in the CENTRAL NERVOUS SYSTEM, and affects multiple neurotransmission systems.
|
| Dose | Unit | Route |
|---|---|---|
| 24 | mmol | O |
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 13 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 95 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 116.00 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| Date | Agency | Company | Orphan |
|---|---|---|---|
| April 6, 1970 | FDA |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Toxicity to various agents | 1443.44 | 12.99 | 1358 | 49346 | 223206 | 56018157 |
| Tremor | 766.85 | 12.99 | 728 | 49976 | 120361 | 56121002 |
| Antipsychotic drug level increased | 747.22 | 12.99 | 223 | 50481 | 3019 | 56238344 |
| Neuroleptic malignant syndrome | 677.97 | 12.99 | 287 | 50417 | 11191 | 56230172 |
| Nephrogenic diabetes insipidus | 649.81 | 12.99 | 153 | 50551 | 747 | 56240616 |
| Drug interaction | 586.97 | 12.99 | 827 | 49877 | 208928 | 56032435 |
| Mania | 540.54 | 12.99 | 245 | 50459 | 11275 | 56230088 |
| Extrapyramidal disorder | 478.15 | 12.99 | 230 | 50474 | 12126 | 56229237 |
| Drug abuse | 366.70 | 12.99 | 374 | 50330 | 67236 | 56174127 |
| Hypomania | 348.51 | 12.99 | 140 | 50564 | 4762 | 56236601 |
| Agitation | 331.49 | 12.99 | 325 | 50379 | 55711 | 56185652 |
| Sopor | 327.62 | 12.99 | 215 | 50489 | 20707 | 56220656 |
| Psychotic disorder | 318.47 | 12.99 | 221 | 50483 | 23337 | 56218026 |
| Antipsychotic drug level above therapeutic | 293.33 | 12.99 | 83 | 50621 | 918 | 56240445 |
| Hyperparathyroidism | 289.48 | 12.99 | 103 | 50601 | 2489 | 56238874 |
| Bipolar disorder | 280.86 | 12.99 | 137 | 50567 | 7443 | 56233920 |
| Rheumatoid arthritis | 280.58 | 12.99 | 16 | 50688 | 382588 | 55858775 |
| Completed suicide | 277.71 | 12.99 | 460 | 50244 | 133373 | 56107990 |
| Confusional state | 273.16 | 12.99 | 588 | 50116 | 207567 | 56033796 |
| Ataxia | 270.36 | 12.99 | 166 | 50538 | 14237 | 56227126 |
| Intentional self-injury | 268.48 | 12.99 | 204 | 50500 | 24788 | 56216575 |
| Schizophrenia | 265.97 | 12.99 | 147 | 50557 | 10352 | 56231011 |
| Tardive dyskinesia | 264.55 | 12.99 | 134 | 50570 | 7897 | 56233466 |
| Suicidal ideation | 262.64 | 12.99 | 291 | 50413 | 57451 | 56183912 |
| Sedation | 259.82 | 12.99 | 230 | 50474 | 34624 | 56206739 |
| Pain | 236.55 | 12.99 | 154 | 50550 | 663030 | 55578333 |
| Suicide attempt | 218.61 | 12.99 | 265 | 50439 | 57571 | 56183792 |
| Parkinsonism | 212.98 | 12.99 | 123 | 50581 | 9423 | 56231940 |
| Dysarthria | 207.43 | 12.99 | 215 | 50489 | 39335 | 56202028 |
| Akathisia | 199.76 | 12.99 | 114 | 50590 | 8538 | 56232825 |
| Hypernatraemia | 199.38 | 12.99 | 104 | 50600 | 6516 | 56234847 |
| Overdose | 197.29 | 12.99 | 347 | 50357 | 105483 | 56135880 |
| Serotonin syndrome | 189.85 | 12.99 | 171 | 50533 | 26319 | 56215044 |
| Muscle rigidity | 185.13 | 12.99 | 117 | 50587 | 10554 | 56230809 |
| Catatonia | 184.92 | 12.99 | 84 | 50620 | 3880 | 56237483 |
| Salivary hypersecretion | 176.61 | 12.99 | 98 | 50606 | 6952 | 56234411 |
| Somnolence | 174.68 | 12.99 | 426 | 50278 | 162987 | 56078376 |
| Disorientation | 172.45 | 12.99 | 188 | 50516 | 36425 | 56204938 |
| Aggression | 167.52 | 12.99 | 147 | 50557 | 21859 | 56219504 |
| Arthralgia | 167.30 | 12.99 | 125 | 50579 | 501544 | 55739819 |
| Drug level increased | 162.91 | 12.99 | 141 | 50563 | 20584 | 56220779 |
| Pleurothotonus | 160.90 | 12.99 | 56 | 50648 | 1265 | 56240098 |
| Myoclonus | 160.83 | 12.99 | 123 | 50581 | 15080 | 56226283 |
| Delusion | 160.47 | 12.99 | 109 | 50595 | 11106 | 56230257 |
| Diabetes insipidus | 154.08 | 12.99 | 64 | 50640 | 2373 | 56238990 |
| Infusion related reaction | 146.27 | 12.99 | 11 | 50693 | 208920 | 56032443 |
| Dyspnoea | 145.58 | 12.99 | 193 | 50511 | 592384 | 55648979 |
| Intentional overdose | 144.94 | 12.99 | 237 | 50467 | 67880 | 56173483 |
| Systemic lupus erythematosus | 143.64 | 12.99 | 4 | 50700 | 180074 | 56061289 |
| Disturbance in attention | 137.65 | 12.99 | 158 | 50546 | 32382 | 56208981 |
| Delirium | 137.06 | 12.99 | 180 | 50524 | 42337 | 56199026 |
| Altered state of consciousness | 135.04 | 12.99 | 133 | 50571 | 22888 | 56218475 |
| Polyuria | 134.01 | 12.99 | 84 | 50620 | 7467 | 56233896 |
| Joint swelling | 132.20 | 12.99 | 48 | 50656 | 289752 | 55951611 |
| Electrocardiogram QT prolonged | 131.41 | 12.99 | 201 | 50503 | 54387 | 56186976 |
| Swelling | 127.09 | 12.99 | 30 | 50674 | 239741 | 56001622 |
| Contraindicated product administered | 127.06 | 12.99 | 11 | 50693 | 186275 | 56055088 |
| Arthropathy | 125.90 | 12.99 | 16 | 50688 | 200259 | 56041104 |
| Hallucination, auditory | 125.78 | 12.99 | 95 | 50609 | 11429 | 56229934 |
| Glossodynia | 119.36 | 12.99 | 4 | 50700 | 152454 | 56088909 |
| Jaundice cholestatic | 117.51 | 12.99 | 69 | 50635 | 5450 | 56235913 |
| Hypersensitivity | 116.02 | 12.99 | 43 | 50661 | 256365 | 55984998 |
| Nasopharyngitis | 112.54 | 12.99 | 30 | 50674 | 220929 | 56020434 |
| Alopecia | 111.38 | 12.99 | 63 | 50641 | 293395 | 55947968 |
| Restlessness | 108.93 | 12.99 | 127 | 50577 | 26459 | 56214904 |
| Irritability | 107.56 | 12.99 | 133 | 50571 | 29455 | 56211908 |
| Depression | 106.13 | 12.99 | 380 | 50324 | 179737 | 56061626 |
| Mental status changes | 106.04 | 12.99 | 149 | 50555 | 37352 | 56204011 |
| Abdominal discomfort | 104.54 | 12.99 | 60 | 50644 | 277214 | 55964149 |
| Abnormal behaviour | 102.30 | 12.99 | 108 | 50596 | 20164 | 56221199 |
| Dyskinesia | 99.69 | 12.99 | 127 | 50577 | 28981 | 56212382 |
| Polydipsia | 97.92 | 12.99 | 51 | 50653 | 3184 | 56238179 |
| Camptocormia | 97.51 | 12.99 | 27 | 50677 | 274 | 56241089 |
| Speech disorder | 97.27 | 12.99 | 143 | 50561 | 37350 | 56204013 |
| Hypothyroidism | 96.68 | 12.99 | 144 | 50560 | 38052 | 56203311 |
| Fatigue | 96.23 | 12.99 | 376 | 50328 | 788176 | 55453187 |
| Drug intolerance | 96.04 | 12.99 | 60 | 50644 | 264758 | 55976605 |
| Sinusitis | 94.77 | 12.99 | 30 | 50674 | 197551 | 56043812 |
| Obsessive-compulsive disorder | 91.41 | 12.99 | 51 | 50653 | 3655 | 56237708 |
| Granulocytopenia | 91.20 | 12.99 | 58 | 50646 | 5286 | 56236077 |
| Encephalopathy | 90.59 | 12.99 | 134 | 50570 | 35191 | 56206172 |
| Neurotoxicity | 90.30 | 12.99 | 90 | 50614 | 15705 | 56225658 |
| Coma | 90.29 | 12.99 | 179 | 50525 | 59476 | 56181887 |
| Hyperreflexia | 89.65 | 12.99 | 57 | 50647 | 5193 | 56236170 |
| Peripheral swelling | 86.74 | 12.99 | 52 | 50652 | 234674 | 56006689 |
| Postural tremor | 85.24 | 12.99 | 23 | 50681 | 210 | 56241153 |
| Mental disorder | 84.03 | 12.99 | 105 | 50599 | 23499 | 56217864 |
| Weight increased | 84.01 | 12.99 | 419 | 50285 | 229284 | 56012079 |
| Depressed level of consciousness | 83.80 | 12.99 | 168 | 50536 | 56265 | 56185098 |
| Bradyphrenia | 82.22 | 12.99 | 59 | 50645 | 6561 | 56234802 |
| Treatment failure | 81.48 | 12.99 | 26 | 50678 | 170366 | 56070997 |
| Poisoning | 80.72 | 12.99 | 77 | 50627 | 12736 | 56228627 |
| Pyramidal tract syndrome | 79.96 | 12.99 | 24 | 50680 | 331 | 56241032 |
| Hypercalcaemia | 79.43 | 12.99 | 106 | 50598 | 25305 | 56216058 |
| Depressed mood | 77.96 | 12.99 | 127 | 50577 | 36232 | 56205131 |
| Pruritus | 77.62 | 12.99 | 103 | 50601 | 316520 | 55924843 |
| Dystonia | 77.03 | 12.99 | 74 | 50630 | 12347 | 56229016 |
| Body tinea | 75.55 | 12.99 | 33 | 50671 | 1387 | 56239976 |
| Stomatitis | 75.04 | 12.99 | 10 | 50694 | 120800 | 56120563 |
| Bipolar I disorder | 73.14 | 12.99 | 34 | 50670 | 1656 | 56239707 |
| Rash | 72.93 | 12.99 | 216 | 50488 | 492831 | 55748532 |
| Libido increased | 71.47 | 12.99 | 31 | 50673 | 1281 | 56240082 |
| Psychomotor hyperactivity | 69.56 | 12.99 | 63 | 50641 | 9757 | 56231606 |
| Mutism | 68.84 | 12.99 | 31 | 50673 | 1402 | 56239961 |
| Apathy | 68.40 | 12.99 | 57 | 50647 | 7897 | 56233466 |
| Inhibitory drug interaction | 68.23 | 12.99 | 36 | 50668 | 2308 | 56239055 |
| Anaemia | 67.63 | 12.99 | 85 | 50619 | 267426 | 55973937 |
| Acute kidney injury | 67.08 | 12.99 | 408 | 50296 | 240355 | 56001008 |
| Blood prolactin increased | 66.87 | 12.99 | 40 | 50664 | 3269 | 56238094 |
| Antipsychotic drug level below therapeutic | 66.83 | 12.99 | 20 | 50684 | 273 | 56241090 |
| Cough | 66.34 | 12.99 | 82 | 50622 | 259879 | 55981484 |
| Aphasia | 66.24 | 12.99 | 107 | 50597 | 30308 | 56211055 |
| Electroencephalogram abnormal | 64.38 | 12.99 | 40 | 50664 | 3499 | 56237864 |
| Pain in extremity | 63.88 | 12.99 | 106 | 50598 | 297325 | 55944038 |
| Infection | 63.83 | 12.99 | 52 | 50652 | 200154 | 56041209 |
| Back pain | 63.52 | 12.99 | 72 | 50632 | 237098 | 56004265 |
| Schizoaffective disorder | 63.13 | 12.99 | 37 | 50667 | 2912 | 56238451 |
| Nephropathy | 62.90 | 12.99 | 47 | 50657 | 5562 | 56235801 |
| Grandiosity | 62.27 | 12.99 | 19 | 50685 | 278 | 56241085 |
| Parathyroid tumour benign | 61.99 | 12.99 | 23 | 50681 | 628 | 56240735 |
| Drug reaction with eosinophilia and systemic symptoms | 61.14 | 12.99 | 103 | 50601 | 30201 | 56211162 |
| Cogwheel rigidity | 60.87 | 12.99 | 31 | 50673 | 1846 | 56239517 |
| Therapeutic product effect decreased | 60.54 | 12.99 | 39 | 50665 | 169413 | 56071950 |
| Cerebellar syndrome | 60.09 | 12.99 | 38 | 50666 | 3429 | 56237934 |
| Psychiatric symptom | 59.76 | 12.99 | 43 | 50661 | 4801 | 56236562 |
| Logorrhoea | 59.74 | 12.99 | 33 | 50671 | 2319 | 56239044 |
| Glucose tolerance impaired | 59.22 | 12.99 | 45 | 50659 | 5460 | 56235903 |
| Paranoia | 59.18 | 12.99 | 60 | 50644 | 10684 | 56230679 |
| Brugada syndrome | 58.77 | 12.99 | 19 | 50685 | 339 | 56241024 |
| Disease progression | 58.01 | 12.99 | 12 | 50692 | 105161 | 56136202 |
| Poisoning deliberate | 57.42 | 12.99 | 57 | 50647 | 9896 | 56231467 |
| Stupor | 57.35 | 12.99 | 39 | 50665 | 3979 | 56237384 |
| Anticholinergic syndrome | 57.14 | 12.99 | 30 | 50674 | 1904 | 56239459 |
| Cognitive disorder | 56.58 | 12.99 | 132 | 50572 | 49001 | 56192362 |
| Febrile neutropenia | 56.27 | 12.99 | 13 | 50691 | 105532 | 56135831 |
| Tachyphrenia | 56.09 | 12.99 | 26 | 50678 | 1258 | 56240105 |
| Galactorrhoea | 56.05 | 12.99 | 38 | 50666 | 3857 | 56237506 |
| Gestational diabetes | 55.68 | 12.99 | 51 | 50653 | 8013 | 56233350 |
| Treatment noncompliance | 55.63 | 12.99 | 103 | 50601 | 32520 | 56208843 |
| Anxiety | 55.46 | 12.99 | 330 | 50374 | 192842 | 56048521 |
| Leukocytosis | 54.98 | 12.99 | 86 | 50618 | 23705 | 56217658 |
| Infection susceptibility increased | 54.57 | 12.99 | 33 | 50671 | 2750 | 56238613 |
| Death | 54.54 | 12.99 | 144 | 50560 | 341282 | 55900081 |
| Malignant neoplasm progression | 54.04 | 12.99 | 3 | 50701 | 73584 | 56167779 |
| Electrocardiogram T wave abnormal | 52.44 | 12.99 | 30 | 50674 | 2256 | 56239107 |
| Impaired healing | 52.03 | 12.99 | 8 | 50696 | 86833 | 56154530 |
| White blood cell count increased | 51.27 | 12.99 | 120 | 50584 | 44639 | 56196724 |
| Gastrointestinal disorder | 50.74 | 12.99 | 19 | 50685 | 112683 | 56128680 |
| Withdrawal syndrome | 50.18 | 12.99 | 72 | 50632 | 18390 | 56222973 |
| Hostility | 50.14 | 12.99 | 27 | 50677 | 1804 | 56239559 |
| Discomfort | 50.13 | 12.99 | 33 | 50671 | 141728 | 56099635 |
| Euphoric mood | 49.94 | 12.99 | 37 | 50667 | 4321 | 56237042 |
| Blister | 49.62 | 12.99 | 18 | 50686 | 108869 | 56132494 |
| Chronic kidney disease | 49.54 | 12.99 | 114 | 50590 | 41942 | 56199421 |
| Enuresis | 49.34 | 12.99 | 29 | 50675 | 2294 | 56239069 |
| Resting tremor | 49.07 | 12.99 | 20 | 50684 | 706 | 56240657 |
| Psychiatric decompensation | 49.01 | 12.99 | 24 | 50680 | 1314 | 56240049 |
| Blood creatine phosphokinase increased | 48.60 | 12.99 | 89 | 50615 | 27863 | 56213500 |
| Bradykinesia | 48.55 | 12.99 | 38 | 50666 | 4816 | 56236547 |
| Atrial fibrillation | 47.96 | 12.99 | 19 | 50685 | 108878 | 56132485 |
| Behaviour disorder | 47.68 | 12.99 | 30 | 50674 | 2683 | 56238680 |
| Headache | 47.55 | 12.99 | 302 | 50402 | 558742 | 55682621 |
| Mental impairment | 47.54 | 12.99 | 58 | 50646 | 12664 | 56228699 |
| Personality disorder | 46.42 | 12.99 | 38 | 50666 | 5135 | 56236228 |
| Drooling | 45.37 | 12.99 | 32 | 50672 | 3462 | 56237901 |
| Action tremor | 45.23 | 12.99 | 15 | 50689 | 291 | 56241072 |
| Product use issue | 45.04 | 12.99 | 61 | 50643 | 185980 | 56055383 |
| Neutrophil count increased | 44.59 | 12.99 | 61 | 50643 | 14904 | 56226459 |
| Cardio-respiratory arrest | 43.60 | 12.99 | 129 | 50575 | 55192 | 56186171 |
| Urticaria | 43.15 | 12.99 | 40 | 50664 | 144636 | 56096727 |
| Hallucination | 42.99 | 12.99 | 119 | 50585 | 49030 | 56192333 |
| Intentional product use issue | 42.95 | 12.99 | 18 | 50686 | 99715 | 56141648 |
| Bundle branch block right | 42.87 | 12.99 | 35 | 50669 | 4712 | 56236651 |
| Renal cyst | 42.41 | 12.99 | 47 | 50657 | 9262 | 56232101 |
| Substance abuse | 42.21 | 12.99 | 34 | 50670 | 4491 | 56236872 |
| Anger | 41.66 | 12.99 | 52 | 50652 | 11620 | 56229743 |
| Arthritis | 41.45 | 12.99 | 19 | 50685 | 99833 | 56141530 |
| Gastrointestinal haemorrhage | 41.19 | 12.99 | 9 | 50695 | 75942 | 56165421 |
| Psychomotor skills impaired | 41.00 | 12.99 | 25 | 50679 | 2115 | 56239248 |
| Sleep-related eating disorder | 40.56 | 12.99 | 18 | 50686 | 786 | 56240577 |
| Oculogyric crisis | 40.41 | 12.99 | 22 | 50682 | 1502 | 56239861 |
| Parkinsonian gait | 39.48 | 12.99 | 15 | 50689 | 438 | 56240925 |
| Asterixis | 39.43 | 12.99 | 20 | 50684 | 1181 | 56240182 |
| Soft tissue injury | 39.42 | 12.99 | 22 | 50682 | 1577 | 56239786 |
| Persecutory delusion | 39.21 | 12.99 | 26 | 50678 | 2544 | 56238819 |
| Cardiac failure congestive | 39.13 | 12.99 | 15 | 50689 | 87705 | 56153658 |
| Cholelithiasis | 39.02 | 12.99 | 100 | 50604 | 39364 | 56201999 |
| Hypothermia | 38.94 | 12.99 | 52 | 50652 | 12418 | 56228945 |
| Lower respiratory tract infection | 38.88 | 12.99 | 28 | 50676 | 114766 | 56126597 |
| Hypertonia | 38.71 | 12.99 | 31 | 50673 | 4061 | 56237302 |
| Lethargy | 38.69 | 12.99 | 118 | 50586 | 51323 | 56190040 |
| Poor quality sleep | 38.02 | 12.99 | 62 | 50642 | 17693 | 56223670 |
| Psoriatic arthropathy | 37.72 | 12.99 | 10 | 50694 | 73998 | 56167365 |
| Hyperprolactinaemia | 37.35 | 12.99 | 29 | 50675 | 3632 | 56237731 |
| Bronchitis | 37.25 | 12.99 | 28 | 50676 | 112283 | 56129080 |
| Urinary incontinence | 36.85 | 12.99 | 82 | 50622 | 29503 | 56211860 |
| Diarrhoea | 36.37 | 12.99 | 384 | 50320 | 638123 | 55603240 |
| Urinary retention | 36.31 | 12.99 | 79 | 50625 | 27995 | 56213368 |
| Goitre | 36.07 | 12.99 | 34 | 50670 | 5539 | 56235824 |
| Abdominal pain upper | 36.00 | 12.99 | 66 | 50638 | 178247 | 56063116 |
| Protein C increased | 35.47 | 12.99 | 10 | 50694 | 109 | 56241254 |
| Electrocardiogram T wave inversion | 35.24 | 12.99 | 27 | 50677 | 3316 | 56238047 |
| Hepatotoxicity | 35.10 | 12.99 | 83 | 50621 | 31070 | 56210293 |
| Mobility decreased | 35.04 | 12.99 | 23 | 50681 | 98968 | 56142395 |
| Thinking abnormal | 35.02 | 12.99 | 44 | 50660 | 9897 | 56231466 |
| Injection site erythema | 34.95 | 12.99 | 13 | 50691 | 77435 | 56163928 |
| Miosis | 34.83 | 12.99 | 36 | 50668 | 6556 | 56234807 |
| Interstitial lung disease | 34.77 | 12.99 | 5 | 50699 | 57058 | 56184305 |
| Visuospatial deficit | 34.76 | 12.99 | 7 | 50697 | 13 | 56241350 |
| Hallucination, visual | 34.73 | 12.99 | 59 | 50645 | 17409 | 56223954 |
| Choreoathetosis | 34.70 | 12.99 | 14 | 50690 | 481 | 56240882 |
| Chest pain | 34.25 | 12.99 | 75 | 50629 | 189722 | 56051641 |
| Haemodialysis | 33.46 | 12.99 | 40 | 50664 | 8551 | 56232812 |
| Blood sodium increased | 32.80 | 12.99 | 23 | 50681 | 2465 | 56238898 |
| Post-traumatic neck syndrome | 32.59 | 12.99 | 21 | 50683 | 1957 | 56239406 |
| Impulsive behaviour | 32.50 | 12.99 | 19 | 50685 | 1488 | 56239875 |
| Myocarditis | 32.47 | 12.99 | 40 | 50664 | 8818 | 56232545 |
| Blood bilirubin increased | 32.44 | 12.99 | 84 | 50620 | 33270 | 56208093 |
| Major depression | 32.35 | 12.99 | 37 | 50667 | 7547 | 56233816 |
| Impaired self-care | 32.12 | 12.99 | 20 | 50684 | 1756 | 56239607 |
| Insomnia | 32.04 | 12.99 | 288 | 50416 | 191572 | 56049791 |
| Hyperlipidaemia | 31.91 | 12.99 | 58 | 50646 | 18051 | 56223312 |
| Sternal fracture | 31.54 | 12.99 | 21 | 50683 | 2069 | 56239294 |
| Asthma | 31.52 | 12.99 | 33 | 50671 | 112737 | 56128626 |
| Renal oncocytoma | 31.48 | 12.99 | 7 | 50697 | 25 | 56241338 |
| Drug withdrawal syndrome | 31.45 | 12.99 | 71 | 50633 | 25786 | 56215577 |
| Gait disturbance | 31.40 | 12.99 | 253 | 50451 | 163068 | 56078295 |
| International normalised ratio abnormal | 31.21 | 12.99 | 24 | 50680 | 2964 | 56238399 |
| Neuropathy peripheral | 31.21 | 12.99 | 28 | 50676 | 102865 | 56138498 |
| Muscle twitching | 31.17 | 12.99 | 54 | 50650 | 16188 | 56225175 |
| Osteoarthritis | 30.74 | 12.99 | 17 | 50687 | 80279 | 56161084 |
| Respiratory arrest | 30.69 | 12.99 | 78 | 50626 | 30547 | 56210816 |
| Hallucinations, mixed | 30.58 | 12.99 | 28 | 50676 | 4396 | 56236967 |
| Pneumonia | 30.54 | 12.99 | 228 | 50476 | 406870 | 55834493 |
| Fibromyalgia | 30.48 | 12.99 | 8 | 50696 | 59595 | 56181768 |
| Hyperthyroidism | 30.48 | 12.99 | 48 | 50656 | 13304 | 56228059 |
| Rhabdomyolysis | 30.33 | 12.99 | 93 | 50611 | 40565 | 56200798 |
| Electrocardiogram abnormal | 30.22 | 12.99 | 37 | 50667 | 8107 | 56233256 |
| Cerebellar atrophy | 30.07 | 12.99 | 14 | 50690 | 684 | 56240679 |
| Mood swings | 29.97 | 12.99 | 54 | 50650 | 16693 | 56224670 |
| Hereditary ataxia | 29.92 | 12.99 | 7 | 50697 | 33 | 56241330 |
| Drug hypersensitivity | 29.77 | 12.99 | 137 | 50567 | 275068 | 55966295 |
| Clonus | 29.58 | 12.99 | 27 | 50677 | 4222 | 56237141 |
| Pressure of speech | 29.50 | 12.99 | 13 | 50691 | 558 | 56240805 |
| Schizoaffective disorder bipolar type | 29.05 | 12.99 | 9 | 50695 | 139 | 56241224 |
| Impaired quality of life | 29.04 | 12.99 | 37 | 50667 | 8437 | 56232926 |
| Drug level above therapeutic | 28.98 | 12.99 | 27 | 50677 | 4335 | 56237028 |
| Papillary thyroid cancer | 28.86 | 12.99 | 20 | 50684 | 2104 | 56239259 |
| Musculoskeletal pain | 28.53 | 12.99 | 19 | 50685 | 81133 | 56160230 |
| Induced abortion failed | 28.52 | 12.99 | 10 | 50694 | 231 | 56241132 |
| Sinus bradycardia | 28.50 | 12.99 | 47 | 50657 | 13539 | 56227824 |
| Electric shock sensation | 27.91 | 12.99 | 12 | 50692 | 485 | 56240878 |
| Social avoidant behaviour | 27.82 | 12.99 | 22 | 50682 | 2830 | 56238533 |
| Depressive symptom | 27.63 | 12.99 | 24 | 50680 | 3517 | 56237846 |
| Adams-Stokes syndrome | 27.34 | 12.99 | 7 | 50697 | 51 | 56241312 |
| Acute psychosis | 27.33 | 12.99 | 20 | 50684 | 2292 | 56239071 |
| Deprescribing error | 27.07 | 12.99 | 6 | 50698 | 21 | 56241342 |
| Persistent depressive disorder | 26.76 | 12.99 | 14 | 50690 | 882 | 56240481 |
| Knee arthroplasty | 26.68 | 12.99 | 4 | 50700 | 44255 | 56197108 |
| Platelet count decreased | 26.63 | 12.99 | 34 | 50670 | 106349 | 56135014 |
| International normalised ratio increased | 26.51 | 12.99 | 4 | 50700 | 44037 | 56197326 |
| Differential white blood cell count abnormal | 26.42 | 12.99 | 13 | 50691 | 719 | 56240644 |
| Mood altered | 26.41 | 12.99 | 45 | 50659 | 13310 | 56228053 |
| Plasma cell myeloma | 26.39 | 12.99 | 5 | 50699 | 46641 | 56194722 |
| Injection site swelling | 26.13 | 12.99 | 4 | 50700 | 43574 | 56197789 |
| Hyperthermia malignant | 26.10 | 12.99 | 13 | 50691 | 738 | 56240625 |
| Nodal rhythm | 26.10 | 12.99 | 17 | 50687 | 1614 | 56239749 |
| Ileus paralytic | 26.02 | 12.99 | 25 | 50679 | 4170 | 56237193 |
| Reflexes abnormal | 25.88 | 12.99 | 12 | 50692 | 581 | 56240782 |
| Maternal exposure during pregnancy | 25.83 | 12.99 | 86 | 50618 | 189467 | 56051896 |
| Cerebrovascular accident | 25.61 | 12.99 | 31 | 50673 | 99239 | 56142124 |
| Abdominal pain | 25.58 | 12.99 | 133 | 50571 | 258672 | 55982691 |
| Sepsis | 25.43 | 12.99 | 55 | 50649 | 139785 | 56101578 |
| Affect lability | 25.36 | 12.99 | 38 | 50666 | 10087 | 56231276 |
| Hypotonia | 25.30 | 12.99 | 35 | 50669 | 8642 | 56232721 |
| Thrombocytopenia | 25.26 | 12.99 | 53 | 50651 | 136171 | 56105192 |
| Hypokinesia | 25.13 | 12.99 | 43 | 50661 | 12760 | 56228603 |
| Increased appetite | 25.12 | 12.99 | 35 | 50669 | 8700 | 56232663 |
| Eye movement disorder | 25.02 | 12.99 | 26 | 50678 | 4763 | 56236600 |
| Thyrotoxic crisis | 24.86 | 12.99 | 13 | 50691 | 818 | 56240545 |
| Muscle contractions involuntary | 24.83 | 12.99 | 18 | 50686 | 2033 | 56239330 |
| Purpura | 24.69 | 12.99 | 38 | 50666 | 10324 | 56231039 |
| COVID-19 | 24.51 | 12.99 | 19 | 50685 | 75039 | 56166324 |
| Myocarditis septic | 24.44 | 12.99 | 6 | 50698 | 36 | 56241327 |
| Nystagmus | 24.14 | 12.99 | 28 | 50676 | 5797 | 56235566 |
| Irritable bowel syndrome | 24.10 | 12.99 | 16 | 50688 | 68442 | 56172921 |
| Paraesthesia | 24.01 | 12.99 | 51 | 50653 | 130463 | 56110900 |
| Injection site pain | 23.94 | 12.99 | 43 | 50661 | 117075 | 56124288 |
| Bruxism | 23.78 | 12.99 | 21 | 50683 | 3145 | 56238218 |
| Sluggishness | 23.78 | 12.99 | 25 | 50679 | 4643 | 56236720 |
| Antidepressant drug level increased | 23.65 | 12.99 | 9 | 50695 | 264 | 56241099 |
| Conversion disorder | 23.62 | 12.99 | 16 | 50688 | 1622 | 56239741 |
| Ammonia increased | 23.52 | 12.99 | 24 | 50680 | 4305 | 56237058 |
| Lung disorder | 23.44 | 12.99 | 9 | 50695 | 52588 | 56188775 |
| Cerebral atrophy | 23.37 | 12.99 | 25 | 50679 | 4735 | 56236628 |
| Affective disorder | 23.33 | 12.99 | 27 | 50677 | 5576 | 56235787 |
| Feeling guilty | 23.28 | 12.99 | 11 | 50693 | 556 | 56240807 |
| Ideas of reference | 22.90 | 12.99 | 7 | 50697 | 103 | 56241260 |
| Pleural effusion | 22.79 | 12.99 | 26 | 50678 | 85454 | 56155909 |
| General physical health deterioration | 22.57 | 12.99 | 78 | 50626 | 169932 | 56071431 |
| Encopresis | 22.42 | 12.99 | 7 | 50697 | 111 | 56241252 |
| Histrionic personality disorder | 22.31 | 12.99 | 6 | 50698 | 54 | 56241309 |
| Poverty of speech | 22.23 | 12.99 | 9 | 50695 | 312 | 56241051 |
| Nausea | 21.94 | 12.99 | 523 | 50181 | 763655 | 55477708 |
| Compulsive sexual behaviour | 21.93 | 12.99 | 6 | 50698 | 58 | 56241305 |
| Coordination abnormal | 21.70 | 12.99 | 40 | 50664 | 12581 | 56228782 |
| Electroconvulsive therapy | 21.66 | 12.99 | 6 | 50698 | 61 | 56241302 |
| Ill-defined disorder | 21.57 | 12.99 | 18 | 50686 | 68525 | 56172838 |
| Mucosal inflammation | 21.41 | 12.99 | 6 | 50698 | 42804 | 56198559 |
| Drug level decreased | 21.36 | 12.99 | 29 | 50675 | 7035 | 56234328 |
| Nephropathy toxic | 21.35 | 12.99 | 32 | 50672 | 8495 | 56232868 |
| Oscillopsia | 21.29 | 12.99 | 7 | 50697 | 132 | 56241231 |
| Status epilepticus | 21.19 | 12.99 | 44 | 50660 | 15097 | 56226266 |
| Language disorder | 21.17 | 12.99 | 16 | 50688 | 1925 | 56239438 |
| Blunted affect | 21.04 | 12.99 | 8 | 50696 | 234 | 56241129 |
| Dialysis | 20.94 | 12.99 | 34 | 50670 | 9668 | 56231695 |
| Borderline personality disorder | 20.66 | 12.99 | 11 | 50693 | 718 | 56240645 |
| Medication error | 20.49 | 12.99 | 84 | 50620 | 42251 | 56199112 |
| Anaphylactic reaction | 20.48 | 12.99 | 14 | 50690 | 58981 | 56182382 |
| Drug ineffective | 20.45 | 12.99 | 652 | 50052 | 918337 | 55323026 |
| Megacolon | 20.37 | 12.99 | 15 | 50689 | 1736 | 56239627 |
| Long QT syndrome | 20.36 | 12.99 | 19 | 50685 | 3057 | 56238306 |
| Limbic encephalitis | 20.28 | 12.99 | 8 | 50696 | 259 | 56241104 |
| Hyporeflexia | 20.21 | 12.99 | 15 | 50689 | 1756 | 56239607 |
| Mydriasis | 20.19 | 12.99 | 36 | 50668 | 11035 | 56230328 |
| Bone pain | 20.13 | 12.99 | 10 | 50694 | 50175 | 56191188 |
| Water intoxication | 19.76 | 12.99 | 9 | 50695 | 418 | 56240945 |
| Lactate pyruvate ratio increased | 19.53 | 12.99 | 6 | 50698 | 90 | 56241273 |
| Disinhibition | 19.44 | 12.99 | 11 | 50693 | 810 | 56240553 |
| Hyperammonaemia | 19.24 | 12.99 | 23 | 50681 | 4917 | 56236446 |
| Hyperthermia | 19.21 | 12.99 | 30 | 50674 | 8255 | 56233108 |
| Rhinorrhoea | 19.19 | 12.99 | 14 | 50690 | 57023 | 56184340 |
| Delusion of reference | 19.00 | 12.99 | 6 | 50698 | 99 | 56241264 |
| Neuropsychiatric symptoms | 18.95 | 12.99 | 10 | 50694 | 641 | 56240722 |
| Flat affect | 18.92 | 12.99 | 13 | 50691 | 1349 | 56240014 |
| Memory impairment | 18.80 | 12.99 | 138 | 50566 | 86419 | 56154944 |
| Lipids decreased | 18.78 | 12.99 | 4 | 50700 | 11 | 56241352 |
| Irregular sleep wake rhythm disorder | 18.77 | 12.99 | 7 | 50697 | 194 | 56241169 |
| Tachycardia | 18.72 | 12.99 | 161 | 50543 | 105715 | 56135648 |
| Arachnoid cyst | 18.70 | 12.99 | 7 | 50697 | 196 | 56241167 |
| Productive cough | 18.66 | 12.99 | 14 | 50690 | 56218 | 56185145 |
| Refusal of treatment by patient | 18.51 | 12.99 | 23 | 50681 | 5115 | 56236248 |
| Self-injurious ideation | 18.48 | 12.99 | 16 | 50688 | 2334 | 56239029 |
| Ear infection | 18.47 | 12.99 | 3 | 50701 | 31292 | 56210071 |
| Homicidal ideation | 18.46 | 12.99 | 14 | 50690 | 1694 | 56239669 |
| Renal impairment | 18.29 | 12.99 | 130 | 50574 | 80583 | 56160780 |
| Merycism | 18.28 | 12.99 | 7 | 50697 | 209 | 56241154 |
| Skin ulcer | 18.24 | 12.99 | 6 | 50698 | 38602 | 56202761 |
| Acquired cystic kidney disease | 18.21 | 12.99 | 5 | 50699 | 49 | 56241314 |
| Agranulocytosis | 18.00 | 12.99 | 53 | 50651 | 22606 | 56218757 |
| Somatic symptom disorder | 17.98 | 12.99 | 15 | 50689 | 2080 | 56239283 |
| Dysphoria | 17.97 | 12.99 | 22 | 50682 | 4820 | 56236543 |
| Urine osmolarity increased | 17.92 | 12.99 | 6 | 50698 | 120 | 56241243 |
| Unresponsive to stimuli | 17.84 | 12.99 | 66 | 50638 | 31659 | 56209704 |
| Cardiac failure | 17.82 | 12.99 | 29 | 50675 | 82064 | 56159299 |
| Staring | 17.80 | 12.99 | 13 | 50691 | 1485 | 56239878 |
| Impaired work ability | 17.71 | 12.99 | 40 | 50664 | 14532 | 56226831 |
| Influenza | 17.71 | 12.99 | 37 | 50667 | 95224 | 56146139 |
| Dyspnoea exertional | 17.66 | 12.99 | 14 | 50690 | 54675 | 56186688 |
| Psychomotor retardation | 17.54 | 12.99 | 19 | 50685 | 3650 | 56237713 |
| Haemorrhage | 17.51 | 12.99 | 15 | 50689 | 56382 | 56184981 |
| Seizure | 17.50 | 12.99 | 181 | 50523 | 124938 | 56116425 |
| Psychotic disorder due to a general medical condition | 17.48 | 12.99 | 7 | 50697 | 236 | 56241127 |
| Throat irritation | 17.46 | 12.99 | 4 | 50700 | 32679 | 56208684 |
| Toxic encephalopathy | 17.38 | 12.99 | 24 | 50680 | 5914 | 56235449 |
| Blood citric acid increased | 17.37 | 12.99 | 5 | 50699 | 59 | 56241304 |
| Hallucination, olfactory | 17.31 | 12.99 | 7 | 50697 | 242 | 56241121 |
| Clear cell renal cell carcinoma | 17.30 | 12.99 | 12 | 50692 | 1264 | 56240099 |
| Essential tremor | 17.20 | 12.99 | 11 | 50693 | 1012 | 56240351 |
| Balance disorder | 17.19 | 12.99 | 123 | 50581 | 76397 | 56164966 |
| Negativism | 17.11 | 12.99 | 8 | 50696 | 395 | 56240968 |
| Antidepressant drug level above therapeutic | 16.92 | 12.99 | 8 | 50696 | 405 | 56240958 |
| Slow speech | 16.88 | 12.99 | 12 | 50692 | 1315 | 56240048 |
| Cardiac arrest | 16.73 | 12.99 | 134 | 50570 | 86180 | 56155183 |
| Pneumonitis | 16.59 | 12.99 | 4 | 50700 | 31560 | 56209803 |
| Alcohol interaction | 16.59 | 12.99 | 15 | 50689 | 2318 | 56239045 |
| Blood urea increased | 16.44 | 12.99 | 54 | 50650 | 24419 | 56216944 |
| Psoriasis | 16.40 | 12.99 | 37 | 50667 | 92655 | 56148708 |
| Compartment syndrome | 16.36 | 12.99 | 14 | 50690 | 2010 | 56239353 |
| Neurological symptom | 16.25 | 12.99 | 21 | 50683 | 4855 | 56236508 |
| Hypotonia neonatal | 16.25 | 12.99 | 11 | 50693 | 1113 | 56240250 |
| Thyroiditis | 16.20 | 12.99 | 14 | 50690 | 2038 | 56239325 |
| Epileptic encephalopathy | 16.17 | 12.99 | 7 | 50697 | 288 | 56241075 |
| Colectomy total | 16.13 | 12.99 | 6 | 50698 | 165 | 56241198 |
| Retroperitoneal fibrosis | 16.07 | 12.99 | 7 | 50697 | 292 | 56241071 |
| Hyperhidrosis | 16.07 | 12.99 | 142 | 50562 | 93946 | 56147417 |
| Pain in jaw | 16.02 | 12.99 | 8 | 50696 | 40028 | 56201335 |
| Osteoporosis | 15.98 | 12.99 | 14 | 50690 | 52038 | 56189325 |
| Acalculia | 15.96 | 12.99 | 3 | 50701 | 3 | 56241360 |
| Potentiating drug interaction | 15.95 | 12.99 | 19 | 50685 | 4047 | 56237316 |
| Ascites | 15.80 | 12.99 | 7 | 50697 | 37537 | 56203826 |
| Antipsychotic drug level decreased | 15.75 | 12.99 | 7 | 50697 | 307 | 56241056 |
| Echolalia | 15.73 | 12.99 | 6 | 50698 | 177 | 56241186 |
| Tonsillar hypertrophy | 15.72 | 12.99 | 10 | 50694 | 912 | 56240451 |
| Urine output increased | 15.58 | 12.99 | 11 | 50693 | 1192 | 56240171 |
| Inflammation | 15.37 | 12.99 | 24 | 50680 | 69047 | 56172316 |
| Malaise | 15.35 | 12.99 | 236 | 50468 | 367624 | 55873739 |
| Slow response to stimuli | 15.31 | 12.99 | 10 | 50694 | 954 | 56240409 |
| Cystitis | 15.28 | 12.99 | 13 | 50691 | 49025 | 56192338 |
| Breast engorgement | 15.17 | 12.99 | 5 | 50699 | 95 | 56241268 |
| Foetal malnutrition | 15.12 | 12.99 | 5 | 50699 | 96 | 56241267 |
| Neonatal respiratory distress | 15.11 | 12.99 | 7 | 50697 | 338 | 56241025 |
| Muscle spasms | 15.06 | 12.99 | 68 | 50636 | 137303 | 56104060 |
| Thought blocking | 14.98 | 12.99 | 5 | 50699 | 99 | 56241264 |
| Haemoglobin decreased | 14.94 | 12.99 | 66 | 50638 | 134071 | 56107292 |
| Blood pressure fluctuation | 14.80 | 12.99 | 9 | 50695 | 40351 | 56201012 |
| Upper respiratory tract infection | 14.72 | 12.99 | 26 | 50678 | 71262 | 56170101 |
| Ileus | 14.58 | 12.99 | 36 | 50668 | 13846 | 56227517 |
| Off label use | 14.47 | 12.99 | 386 | 50318 | 555794 | 55685569 |
| Gaze palsy | 14.41 | 12.99 | 11 | 50693 | 1344 | 56240019 |
| Injection site reaction | 14.41 | 12.99 | 16 | 50688 | 53231 | 56188132 |
| Delusional perception | 14.40 | 12.99 | 6 | 50698 | 224 | 56241139 |
| Movement disorder | 14.39 | 12.99 | 44 | 50660 | 19154 | 56222209 |
| Suspected suicide | 14.39 | 12.99 | 21 | 50683 | 5445 | 56235918 |
| Osteonecrosis of jaw | 14.39 | 12.99 | 6 | 50698 | 33352 | 56208011 |
| Bone density decreased | 14.38 | 12.99 | 34 | 50670 | 12726 | 56228637 |
| Cardiomyopathy acute | 14.33 | 12.99 | 6 | 50698 | 227 | 56241136 |
| Stevens-Johnson syndrome | 14.33 | 12.99 | 49 | 50655 | 22614 | 56218749 |
| Distal intestinal obstruction syndrome | 14.26 | 12.99 | 7 | 50697 | 385 | 56240978 |
| Sexually inappropriate behaviour | 14.16 | 12.99 | 5 | 50699 | 118 | 56241245 |
| Glomerulonephritis minimal lesion | 14.09 | 12.99 | 6 | 50698 | 237 | 56241126 |
| Melaena | 14.08 | 12.99 | 4 | 50700 | 28286 | 56213077 |
| Femur fracture | 14.08 | 12.99 | 9 | 50695 | 39286 | 56202077 |
| Wheezing | 14.06 | 12.99 | 29 | 50675 | 74997 | 56166366 |
| Dysphemia | 14.03 | 12.99 | 14 | 50690 | 2446 | 56238917 |
| Decreased activity | 14.01 | 12.99 | 21 | 50683 | 5575 | 56235788 |
| Joint injury | 13.99 | 12.99 | 3 | 50701 | 25651 | 56215712 |
| Loss of personal independence in daily activities | 13.98 | 12.99 | 33 | 50671 | 81336 | 56160027 |
| Breast cancer | 13.97 | 12.99 | 14 | 50690 | 48819 | 56192544 |
| Tooth injury | 13.90 | 12.99 | 10 | 50694 | 1116 | 56240247 |
| Thought insertion | 13.89 | 12.99 | 3 | 50701 | 9 | 56241354 |
| Polyhydramnios | 13.87 | 12.99 | 13 | 50691 | 2102 | 56239261 |
| Muscle tone disorder | 13.85 | 12.99 | 5 | 50699 | 126 | 56241237 |
| Thrombosis | 13.85 | 12.99 | 20 | 50684 | 59407 | 56181956 |
| Progressive supranuclear palsy | 13.84 | 12.99 | 4 | 50700 | 48 | 56241315 |
| Stereotypy | 13.77 | 12.99 | 7 | 50697 | 415 | 56240948 |
| Blood pressure systolic increased | 13.77 | 12.99 | 10 | 50694 | 40826 | 56200537 |
| Joint range of motion decreased | 13.76 | 12.99 | 3 | 50701 | 25362 | 56216001 |
| Distractibility | 13.68 | 12.99 | 7 | 50697 | 421 | 56240942 |
| Amenorrhoea | 13.63 | 12.99 | 27 | 50677 | 8959 | 56232404 |
| Cerebellar ataxia | 13.60 | 12.99 | 9 | 50695 | 878 | 56240485 |
| Unmasking of previously unidentified disease | 13.57 | 12.99 | 9 | 50695 | 881 | 56240482 |
| Haematoma | 13.43 | 12.99 | 6 | 50698 | 32013 | 56209350 |
| Localised infection | 13.42 | 12.99 | 4 | 50700 | 27408 | 56213955 |
| Abulia | 13.38 | 12.99 | 7 | 50697 | 441 | 56240922 |
| Brain injury | 13.35 | 12.99 | 22 | 50682 | 6333 | 56235030 |
| Epistaxis | 13.34 | 12.99 | 25 | 50679 | 66998 | 56174365 |
| Amimia | 13.34 | 12.99 | 4 | 50700 | 55 | 56241308 |
| Food craving | 13.30 | 12.99 | 11 | 50693 | 1508 | 56239855 |
| Respiratory tract infection | 13.28 | 12.99 | 8 | 50696 | 36063 | 56205300 |
| Middle insomnia | 13.24 | 12.99 | 30 | 50674 | 10920 | 56230443 |
| Neutrophilia | 13.21 | 12.99 | 17 | 50687 | 3916 | 56237447 |
| Liver injury | 13.15 | 12.99 | 11 | 50693 | 41837 | 56199526 |
| Haematochezia | 13.13 | 12.99 | 12 | 50692 | 43706 | 56197657 |
| Hip fracture | 13.08 | 12.99 | 4 | 50700 | 26969 | 56214394 |
| Urinary tract infection | 13.07 | 12.99 | 146 | 50558 | 240367 | 56000996 |
| Dry eye | 13.04 | 12.99 | 8 | 50696 | 35708 | 56205655 |
| Nightmare | 13.02 | 12.99 | 39 | 50665 | 16787 | 56224576 |
| Blood pressure increased | 13.01 | 12.99 | 77 | 50627 | 145099 | 56096264 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Toxicity to various agents | 850.92 | 14.24 | 1073 | 37615 | 180414 | 31478242 |
| Neuroleptic malignant syndrome | 593.48 | 14.24 | 325 | 38363 | 16544 | 31642112 |
| Antipsychotic drug level increased | 557.13 | 14.24 | 195 | 38493 | 3263 | 31655393 |
| Mania | 547.66 | 14.24 | 253 | 38435 | 8924 | 31649732 |
| Tremor | 525.47 | 14.24 | 552 | 38136 | 75868 | 31582788 |
| Nephrogenic diabetes insipidus | 402.13 | 14.24 | 118 | 38570 | 1076 | 31657580 |
| Akathisia | 306.48 | 14.24 | 158 | 38530 | 7095 | 31651561 |
| Suicide attempt | 288.04 | 14.24 | 287 | 38401 | 36961 | 31621695 |
| Extrapyramidal disorder | 267.11 | 14.24 | 171 | 38517 | 11607 | 31647049 |
| Obsessive-compulsive disorder | 266.33 | 14.24 | 127 | 38561 | 4810 | 31653846 |
| Parkinsonism | 246.16 | 14.24 | 139 | 38549 | 7497 | 31651159 |
| Antipsychotic drug level below therapeutic | 240.16 | 14.24 | 91 | 38597 | 1924 | 31656732 |
| Drug interaction | 233.29 | 14.24 | 668 | 38020 | 207875 | 31450781 |
| Bipolar disorder | 204.54 | 14.24 | 97 | 38591 | 3627 | 31655029 |
| Serotonin syndrome | 199.94 | 14.24 | 173 | 38515 | 18600 | 31640056 |
| Psychotic disorder | 197.14 | 14.24 | 185 | 38503 | 22108 | 31636548 |
| Antipsychotic drug level above therapeutic | 184.28 | 14.24 | 65 | 38623 | 1112 | 31657544 |
| Dysarthria | 165.96 | 14.24 | 200 | 38488 | 31817 | 31626839 |
| Disinhibition | 159.80 | 14.24 | 74 | 38614 | 2619 | 31656037 |
| Euphoric mood | 159.75 | 14.24 | 90 | 38598 | 4830 | 31653826 |
| Suicidal ideation | 157.83 | 14.24 | 208 | 38480 | 36198 | 31622458 |
| Agitation | 155.79 | 14.24 | 255 | 38433 | 53914 | 31604742 |
| Psychomotor hyperactivity | 154.60 | 14.24 | 109 | 38579 | 8678 | 31649978 |
| Therapeutic product effect variable | 152.79 | 14.24 | 65 | 38623 | 1873 | 31656783 |
| Granulocytopenia | 151.91 | 14.24 | 94 | 38594 | 6005 | 31652651 |
| Sedation | 148.08 | 14.24 | 147 | 38541 | 18818 | 31639838 |
| Hypomania | 147.06 | 14.24 | 66 | 38622 | 2169 | 31656487 |
| Increased appetite | 146.02 | 14.24 | 93 | 38595 | 6251 | 31652405 |
| Diabetes insipidus | 145.14 | 14.24 | 68 | 38620 | 2472 | 31656184 |
| Weight increased | 139.85 | 14.24 | 311 | 38377 | 82636 | 31576020 |
| Confusional state | 135.18 | 14.24 | 413 | 38275 | 132921 | 31525735 |
| Aggression | 131.61 | 14.24 | 193 | 38495 | 37098 | 31621558 |
| Ataxia | 123.88 | 14.24 | 112 | 38576 | 12751 | 31645905 |
| Dyspnoea | 123.42 | 14.24 | 143 | 38545 | 343336 | 31315320 |
| Irritability | 121.90 | 14.24 | 145 | 38543 | 22744 | 31635912 |
| Febrile neutropenia | 117.60 | 14.24 | 8 | 38680 | 121841 | 31536815 |
| Dyskinesia | 113.89 | 14.24 | 134 | 38554 | 20776 | 31637880 |
| Salivary hypersecretion | 112.95 | 14.24 | 86 | 38602 | 7706 | 31650950 |
| Schizophrenia | 105.67 | 14.24 | 95 | 38593 | 10735 | 31647921 |
| Delusion | 103.03 | 14.24 | 98 | 38590 | 11899 | 31646757 |
| Schizoaffective disorder | 101.29 | 14.24 | 43 | 38645 | 1232 | 31657424 |
| Completed suicide | 100.72 | 14.24 | 292 | 38396 | 91222 | 31567434 |
| Hallucination, auditory | 99.35 | 14.24 | 90 | 38598 | 10270 | 31648386 |
| Death | 95.61 | 14.24 | 185 | 38503 | 360384 | 31298272 |
| Myoclonus | 93.92 | 14.24 | 100 | 38588 | 13890 | 31644766 |
| Tardive dyskinesia | 93.26 | 14.24 | 67 | 38621 | 5492 | 31653164 |
| Hypernatraemia | 90.54 | 14.24 | 75 | 38613 | 7588 | 31651068 |
| Arthralgia | 90.22 | 14.24 | 36 | 38652 | 151388 | 31507268 |
| Muscle rigidity | 89.11 | 14.24 | 83 | 38605 | 9814 | 31648842 |
| Leukopenia | 87.63 | 14.24 | 208 | 38480 | 57620 | 31601036 |
| Bruxism | 85.06 | 14.24 | 41 | 38647 | 1589 | 31657067 |
| Anaemia | 83.06 | 14.24 | 83 | 38605 | 213439 | 31445217 |
| Priapism | 82.86 | 14.24 | 58 | 38630 | 4562 | 31654094 |
| Overdose | 82.63 | 14.24 | 259 | 38429 | 84405 | 31574251 |
| Hyperparathyroidism | 81.33 | 14.24 | 36 | 38652 | 1144 | 31657512 |
| Somnolence | 78.29 | 14.24 | 283 | 38405 | 99162 | 31559494 |
| White blood cell count increased | 78.12 | 14.24 | 157 | 38531 | 38843 | 31619813 |
| Cough | 77.16 | 14.24 | 34 | 38654 | 134780 | 31523876 |
| Catatonia | 76.16 | 14.24 | 56 | 38632 | 4758 | 31653898 |
| Sopor | 74.77 | 14.24 | 81 | 38607 | 11471 | 31647185 |
| Oppositional defiant disorder | 74.01 | 14.24 | 27 | 38661 | 511 | 31658145 |
| Delirium | 73.89 | 14.24 | 159 | 38529 | 41262 | 31617394 |
| Pain | 72.14 | 14.24 | 73 | 38615 | 186686 | 31471970 |
| Coordination abnormal | 71.51 | 14.24 | 64 | 38624 | 7187 | 31651469 |
| Decreased eye contact | 68.98 | 14.24 | 25 | 38663 | 464 | 31658192 |
| Intentional overdose | 68.31 | 14.24 | 154 | 38534 | 41235 | 31617421 |
| Abnormal behaviour | 68.19 | 14.24 | 112 | 38576 | 23716 | 31634940 |
| Disease progression | 67.62 | 14.24 | 14 | 38674 | 90450 | 31568206 |
| Pneumonia | 65.91 | 14.24 | 201 | 38487 | 335111 | 31323545 |
| Pain in extremity | 65.39 | 14.24 | 30 | 38658 | 116173 | 31542483 |
| Mental status changes | 65.22 | 14.24 | 139 | 38549 | 35829 | 31622827 |
| Homicidal ideation | 64.68 | 14.24 | 40 | 38648 | 2551 | 31656105 |
| Malignant neoplasm progression | 63.86 | 14.24 | 10 | 38678 | 78988 | 31579668 |
| Dyslipidaemia | 62.10 | 14.24 | 56 | 38632 | 6350 | 31652306 |
| Coma | 61.21 | 14.24 | 147 | 38541 | 41003 | 31617653 |
| Cognitive disorder | 59.34 | 14.24 | 108 | 38580 | 24815 | 31633841 |
| Blood creatine phosphokinase increased | 59.30 | 14.24 | 147 | 38541 | 41827 | 31616829 |
| Neutrophil count increased | 59.23 | 14.24 | 84 | 38604 | 15647 | 31643009 |
| Polydipsia | 57.86 | 14.24 | 42 | 38646 | 3498 | 31655158 |
| Hyperreflexia | 57.55 | 14.24 | 39 | 38649 | 2910 | 31655746 |
| Depressed level of consciousness | 55.39 | 14.24 | 136 | 38552 | 38465 | 31620191 |
| Restlessness | 55.32 | 14.24 | 101 | 38587 | 23260 | 31635396 |
| Obesity | 55.29 | 14.24 | 68 | 38620 | 11032 | 31647624 |
| Bipolar I disorder | 53.43 | 14.24 | 24 | 38664 | 790 | 31657866 |
| Dystonia | 53.14 | 14.24 | 64 | 38624 | 10161 | 31648495 |
| Brugada syndrome | 53.04 | 14.24 | 23 | 38665 | 695 | 31657961 |
| Depression | 51.89 | 14.24 | 234 | 38454 | 90581 | 31568075 |
| Affect lability | 51.89 | 14.24 | 39 | 38649 | 3426 | 31655230 |
| Prescribed overdose | 51.85 | 14.24 | 60 | 38628 | 9132 | 31649524 |
| Disturbance in attention | 51.82 | 14.24 | 96 | 38592 | 22354 | 31636302 |
| Atrial fibrillation | 51.76 | 14.24 | 38 | 38650 | 113745 | 31544911 |
| Pancytopenia | 51.56 | 14.24 | 21 | 38667 | 87295 | 31571361 |
| Interstitial lung disease | 51.41 | 14.24 | 7 | 38681 | 61396 | 31597260 |
| Disorientation | 51.40 | 14.24 | 115 | 38573 | 30629 | 31628027 |
| Back pain | 50.47 | 14.24 | 36 | 38652 | 109377 | 31549279 |
| Neurotoxicity | 50.15 | 14.24 | 79 | 38609 | 16147 | 31642509 |
| Treatment noncompliance | 49.75 | 14.24 | 102 | 38586 | 25582 | 31633074 |
| Speech disorder | 49.13 | 14.24 | 98 | 38590 | 24103 | 31634553 |
| Thinking abnormal | 48.75 | 14.24 | 46 | 38642 | 5527 | 31653129 |
| Fatigue | 47.08 | 14.24 | 230 | 38458 | 334976 | 31323680 |
| Pruritus | 47.06 | 14.24 | 50 | 38638 | 125117 | 31533539 |
| Myocarditis | 46.96 | 14.24 | 65 | 38623 | 11835 | 31646821 |
| Hypothyroidism | 46.88 | 14.24 | 81 | 38607 | 17866 | 31640790 |
| Dystonic tremor | 46.66 | 14.24 | 15 | 38673 | 190 | 31658466 |
| Rheumatoid arthritis | 46.49 | 14.24 | 3 | 38685 | 47806 | 31610850 |
| Anxiety | 46.46 | 14.24 | 227 | 38461 | 90806 | 31567850 |
| Peripheral swelling | 45.82 | 14.24 | 13 | 38675 | 67852 | 31590804 |
| Oedema peripheral | 45.80 | 14.24 | 40 | 38648 | 109799 | 31548857 |
| Thrombocytopenia | 45.30 | 14.24 | 65 | 38623 | 142682 | 31515974 |
| Electrocardiogram QRS complex prolonged | 45.05 | 14.24 | 39 | 38649 | 4190 | 31654466 |
| Plasma cell myeloma | 43.81 | 14.24 | 8 | 38680 | 56523 | 31602133 |
| Clonus | 43.72 | 14.24 | 31 | 38657 | 2488 | 31656168 |
| Paranoia | 43.69 | 14.24 | 59 | 38629 | 10496 | 31648160 |
| Delusion of grandeur | 43.46 | 14.24 | 20 | 38668 | 697 | 31657959 |
| General physical health deterioration | 42.99 | 14.24 | 45 | 38643 | 113390 | 31545266 |
| Cardiac failure congestive | 42.35 | 14.24 | 22 | 38666 | 79365 | 31579291 |
| Gastrointestinal haemorrhage | 40.98 | 14.24 | 25 | 38663 | 82524 | 31576132 |
| Sepsis | 40.91 | 14.24 | 77 | 38611 | 151852 | 31506804 |
| Affective disorder | 40.90 | 14.24 | 35 | 38653 | 3701 | 31654955 |
| Cerebellar syndrome | 40.56 | 14.24 | 28 | 38660 | 2153 | 31656503 |
| Failure to suspend medication | 39.57 | 14.24 | 16 | 38672 | 404 | 31658252 |
| Choreoathetosis | 39.33 | 14.24 | 21 | 38667 | 1012 | 31657644 |
| Rash | 39.31 | 14.24 | 121 | 38567 | 201365 | 31457291 |
| Infusion related reaction | 39.01 | 14.24 | 6 | 38682 | 48049 | 31610607 |
| Logorrhoea | 39.01 | 14.24 | 28 | 38660 | 2291 | 31656365 |
| Myocardial infarction | 38.68 | 14.24 | 49 | 38639 | 113405 | 31545251 |
| Intentional self-injury | 38.64 | 14.24 | 63 | 38625 | 13252 | 31645404 |
| Insomnia | 37.82 | 14.24 | 221 | 38467 | 94615 | 31564041 |
| Tachycardia foetal | 37.77 | 14.24 | 15 | 38673 | 361 | 31658295 |
| Electrocardiogram QT prolonged | 37.73 | 14.24 | 117 | 38571 | 37870 | 31620786 |
| Drug level above therapeutic | 37.08 | 14.24 | 33 | 38655 | 3677 | 31654979 |
| Hyperparathyroidism primary | 37.04 | 14.24 | 12 | 38676 | 156 | 31658500 |
| Blood thyroid stimulating hormone decreased | 36.97 | 14.24 | 25 | 38663 | 1858 | 31656798 |
| Nephropathy | 34.72 | 14.24 | 38 | 38650 | 5441 | 31653215 |
| Apathy | 34.38 | 14.24 | 41 | 38647 | 6441 | 31652215 |
| Balance disorder | 34.19 | 14.24 | 112 | 38576 | 37310 | 31621346 |
| Anger | 34.05 | 14.24 | 54 | 38634 | 11099 | 31647557 |
| Tachycardia | 33.96 | 14.24 | 183 | 38505 | 76024 | 31582632 |
| Leukocytosis | 33.95 | 14.24 | 80 | 38608 | 22034 | 31636622 |
| Enuresis | 33.63 | 14.24 | 25 | 38663 | 2159 | 31656497 |
| Psychiatric decompensation | 33.56 | 14.24 | 24 | 38664 | 1952 | 31656704 |
| Antipsychotic drug level decreased | 33.40 | 14.24 | 18 | 38670 | 884 | 31657772 |
| Drug level increased | 33.16 | 14.24 | 75 | 38613 | 20111 | 31638545 |
| Mental impairment | 33.11 | 14.24 | 49 | 38639 | 9483 | 31649173 |
| Joint swelling | 32.94 | 14.24 | 12 | 38676 | 53419 | 31605237 |
| Septic shock | 32.88 | 14.24 | 20 | 38668 | 66138 | 31592518 |
| Grandiosity | 32.80 | 14.24 | 13 | 38675 | 311 | 31658345 |
| Abulia | 32.59 | 14.24 | 15 | 38673 | 523 | 31658133 |
| Hyperkinesia | 32.34 | 14.24 | 22 | 38666 | 1651 | 31657005 |
| Hyperprolactinaemia | 32.19 | 14.24 | 21 | 38667 | 1470 | 31657186 |
| Distractibility | 31.62 | 14.24 | 13 | 38675 | 343 | 31658313 |
| Trismus | 31.49 | 14.24 | 25 | 38663 | 2380 | 31656276 |
| Polyuria | 31.44 | 14.24 | 43 | 38645 | 7740 | 31650916 |
| Pressure of speech | 31.30 | 14.24 | 14 | 38674 | 456 | 31658200 |
| Diarrhoea | 31.10 | 14.24 | 278 | 38410 | 352131 | 31306525 |
| Leukaemia | 31.03 | 14.24 | 31 | 38657 | 3994 | 31654662 |
| Blood prolactin increased | 30.55 | 14.24 | 21 | 38667 | 1603 | 31657053 |
| Patient restraint | 30.28 | 14.24 | 9 | 38679 | 86 | 31658570 |
| Prostate cancer | 29.83 | 14.24 | 5 | 38683 | 37596 | 31621060 |
| Mental disorder | 29.25 | 14.24 | 57 | 38631 | 13777 | 31644879 |
| Melaena | 29.11 | 14.24 | 3 | 38685 | 32651 | 31626005 |
| Coronary artery disease | 29.01 | 14.24 | 10 | 38678 | 46077 | 31612579 |
| Metabolic syndrome | 28.91 | 14.24 | 20 | 38668 | 1543 | 31657113 |
| Abdominal pain | 28.90 | 14.24 | 87 | 38601 | 145865 | 31512791 |
| Epistaxis | 28.46 | 14.24 | 15 | 38673 | 53692 | 31604964 |
| Decreased appetite | 28.46 | 14.24 | 94 | 38594 | 153123 | 31505533 |
| Sexually inappropriate behaviour | 28.44 | 14.24 | 13 | 38675 | 446 | 31658210 |
| Thrombosis | 28.07 | 14.24 | 10 | 38678 | 45141 | 31613515 |
| Sexual dysfunction | 27.23 | 14.24 | 35 | 38653 | 5933 | 31652723 |
| Acute myocardial infarction | 27.22 | 14.24 | 14 | 38674 | 50809 | 31607847 |
| Bradyphrenia | 26.97 | 14.24 | 30 | 38658 | 4374 | 31654282 |
| Eosinophil count decreased | 26.47 | 14.24 | 17 | 38671 | 1158 | 31657498 |
| Mucosal inflammation | 26.39 | 14.24 | 5 | 38683 | 34422 | 31624234 |
| Headache | 26.28 | 14.24 | 125 | 38563 | 183527 | 31475129 |
| Lethargy | 26.24 | 14.24 | 105 | 38583 | 38536 | 31620120 |
| Haemoptysis | 26.17 | 14.24 | 4 | 38684 | 32185 | 31626471 |
| Hyperthermia | 25.92 | 14.24 | 45 | 38643 | 9959 | 31648697 |
| Poisoning deliberate | 25.86 | 14.24 | 38 | 38650 | 7306 | 31651350 |
| Intentional product use issue | 25.83 | 14.24 | 14 | 38674 | 49333 | 31609323 |
| Restless legs syndrome | 25.69 | 14.24 | 39 | 38649 | 7717 | 31650939 |
| Blunted affect | 25.59 | 14.24 | 11 | 38677 | 325 | 31658331 |
| Cardiac failure | 25.44 | 14.24 | 41 | 38647 | 85912 | 31572744 |
| Infection | 25.28 | 14.24 | 38 | 38650 | 81893 | 31576763 |
| Therapeutic product effect incomplete | 25.22 | 14.24 | 113 | 38575 | 43583 | 31615073 |
| Flight of ideas | 25.16 | 14.24 | 11 | 38677 | 339 | 31658317 |
| Blood sodium increased | 25.00 | 14.24 | 23 | 38665 | 2676 | 31655980 |
| Cogwheel rigidity | 24.91 | 14.24 | 17 | 38671 | 1283 | 31657373 |
| Pleural effusion | 24.85 | 14.24 | 33 | 38655 | 74887 | 31583769 |
| Hypersensitivity | 24.83 | 14.24 | 19 | 38669 | 55724 | 31602932 |
| Metabolic encephalopathy | 24.69 | 14.24 | 27 | 38661 | 3862 | 31654794 |
| Neuropathy peripheral | 24.41 | 14.24 | 34 | 38654 | 75615 | 31583041 |
| Cerebrovascular accident | 24.40 | 14.24 | 37 | 38651 | 79447 | 31579209 |
| Major depression | 24.39 | 14.24 | 28 | 38660 | 4225 | 31654431 |
| Otospondylomegaepiphyseal dysplasia | 24.35 | 14.24 | 8 | 38680 | 109 | 31658547 |
| Crying | 24.25 | 14.24 | 32 | 38656 | 5565 | 31653091 |
| Electroconvulsive therapy | 24.25 | 14.24 | 6 | 38682 | 26 | 31658630 |
| Drooling | 24.16 | 14.24 | 24 | 38664 | 3071 | 31655585 |
| Muscle spasms | 23.79 | 14.24 | 29 | 38659 | 68289 | 31590367 |
| Schizoaffective disorder bipolar type | 23.73 | 14.24 | 7 | 38681 | 65 | 31658591 |
| Musculoskeletal pain | 23.59 | 14.24 | 4 | 38684 | 29824 | 31628832 |
| Productive cough | 23.43 | 14.24 | 6 | 38682 | 33534 | 31625122 |
| Blood triglycerides increased | 23.38 | 14.24 | 51 | 38637 | 13346 | 31645310 |
| Sleep disorder | 23.30 | 14.24 | 78 | 38610 | 26270 | 31632386 |
| Depressed mood | 23.19 | 14.24 | 60 | 38628 | 17515 | 31641141 |
| Persistent depressive disorder | 23.09 | 14.24 | 10 | 38678 | 301 | 31658355 |
| Cerebral haemorrhage | 22.67 | 14.24 | 6 | 38682 | 32806 | 31625850 |
| Encephalopathy | 22.66 | 14.24 | 89 | 38599 | 32385 | 31626271 |
| Haemorrhage | 22.57 | 14.24 | 15 | 38673 | 47319 | 31611337 |
| Agranulocytosis | 22.55 | 14.24 | 67 | 38621 | 21180 | 31637476 |
| Hypotonia neonatal | 22.47 | 14.24 | 16 | 38672 | 1293 | 31657363 |
| Pneumonitis | 22.36 | 14.24 | 5 | 38683 | 30647 | 31628009 |
| Hydrops foetalis | 22.24 | 14.24 | 11 | 38677 | 451 | 31658205 |
| Altered state of consciousness | 21.98 | 14.24 | 66 | 38622 | 20985 | 31637671 |
| Self-injurious ideation | 21.87 | 14.24 | 17 | 38671 | 1570 | 31657086 |
| Angioedema | 21.67 | 14.24 | 7 | 38681 | 33611 | 31625045 |
| Anaphylactic reaction | 21.20 | 14.24 | 5 | 38683 | 29548 | 31629108 |
| Arthritis | 20.94 | 14.24 | 4 | 38684 | 27381 | 31631275 |
| Diabetes mellitus | 20.88 | 14.24 | 105 | 38583 | 42451 | 31616205 |
| Feelings of worthlessness | 20.84 | 14.24 | 9 | 38679 | 269 | 31658387 |
| Hepatic failure | 20.74 | 14.24 | 7 | 38681 | 32695 | 31625961 |
| Urinary incontinence | 20.69 | 14.24 | 57 | 38631 | 17263 | 31641393 |
| Apraxia | 20.64 | 14.24 | 15 | 38673 | 1251 | 31657405 |
| Urticaria | 20.47 | 14.24 | 24 | 38664 | 57493 | 31601163 |
| Floppy infant | 20.39 | 14.24 | 7 | 38681 | 110 | 31658546 |
| Gait disturbance | 20.36 | 14.24 | 163 | 38525 | 77332 | 31581324 |
| Dyspnoea exertional | 20.35 | 14.24 | 11 | 38677 | 38826 | 31619830 |
| Memory impairment | 20.08 | 14.24 | 96 | 38592 | 38034 | 31620622 |
| Psychotic symptom | 19.86 | 14.24 | 16 | 38672 | 1556 | 31657100 |
| Erythema | 19.70 | 14.24 | 43 | 38645 | 80362 | 31578294 |
| Mood altered | 19.64 | 14.24 | 36 | 38652 | 8310 | 31650346 |
| Bone marrow failure | 19.58 | 14.24 | 5 | 38683 | 28003 | 31630653 |
| Renal cyst | 19.43 | 14.24 | 36 | 38652 | 8380 | 31650276 |
| Chest discomfort | 19.35 | 14.24 | 19 | 38669 | 49350 | 31609306 |
| Drug hypersensitivity | 19.33 | 14.24 | 37 | 38651 | 72562 | 31586094 |
| Bipolar II disorder | 19.30 | 14.24 | 5 | 38683 | 27 | 31658629 |
| Movement disorder | 19.29 | 14.24 | 42 | 38646 | 10977 | 31647679 |
| Stupor | 18.85 | 14.24 | 20 | 38668 | 2764 | 31655892 |
| Eosinophil count increased | 18.84 | 14.24 | 34 | 38654 | 7757 | 31650899 |
| Antipsychotic drug level | 18.80 | 14.24 | 4 | 38684 | 7 | 31658649 |
| Oncocytoma | 18.80 | 14.24 | 4 | 38684 | 7 | 31658649 |
| Staphylococcal infection | 18.67 | 14.24 | 7 | 38681 | 30625 | 31628031 |
| Upper gastrointestinal haemorrhage | 18.57 | 14.24 | 3 | 38685 | 23180 | 31635476 |
| Dysphemia | 18.44 | 14.24 | 15 | 38673 | 1479 | 31657177 |
| Wrong patient received product | 18.43 | 14.24 | 19 | 38669 | 2540 | 31656116 |
| Weight decreased | 18.40 | 14.24 | 117 | 38571 | 159835 | 31498821 |
| Herpes zoster | 18.38 | 14.24 | 8 | 38680 | 31985 | 31626671 |
| Impulsive behaviour | 18.34 | 14.24 | 17 | 38671 | 1996 | 31656660 |
| Convulsive threshold lowered | 18.30 | 14.24 | 10 | 38678 | 505 | 31658151 |
| Speech sound disorder | 18.21 | 14.24 | 7 | 38681 | 154 | 31658502 |
| Abdominal distension | 18.20 | 14.24 | 21 | 38667 | 50663 | 31607993 |
| International normalised ratio increased | 18.20 | 14.24 | 17 | 38671 | 45206 | 31613450 |
| Blood thyroid stimulating hormone increased | 18.15 | 14.24 | 22 | 38666 | 3515 | 31655141 |
| Differential white blood cell count abnormal | 17.95 | 14.24 | 14 | 38674 | 1299 | 31657357 |
| Poor quality sleep | 17.92 | 14.24 | 33 | 38655 | 7645 | 31651011 |
| Angina pectoris | 17.69 | 14.24 | 7 | 38681 | 29634 | 31629022 |
| Depressive symptom | 17.63 | 14.24 | 17 | 38671 | 2097 | 31656559 |
| Social anxiety disorder | 17.60 | 14.24 | 8 | 38680 | 271 | 31658385 |
| Kidney enlargement | 17.53 | 14.24 | 11 | 38677 | 720 | 31657936 |
| Gambling disorder | 17.52 | 14.24 | 15 | 38673 | 1587 | 31657069 |
| Muscle twitching | 17.51 | 14.24 | 34 | 38654 | 8196 | 31650460 |
| Haematoma | 17.48 | 14.24 | 4 | 38684 | 24135 | 31634521 |
| Cerebral infarction | 17.48 | 14.24 | 5 | 38683 | 25972 | 31632684 |
| Libido increased | 17.46 | 14.24 | 11 | 38677 | 725 | 31657931 |
| High-grade B-cell lymphoma | 17.41 | 14.24 | 7 | 38681 | 174 | 31658482 |
| Syncope | 17.40 | 14.24 | 50 | 38638 | 85132 | 31573524 |
| Secondary tic | 17.31 | 14.24 | 4 | 38684 | 12 | 31658644 |
| Autonomic nervous system imbalance | 17.20 | 14.24 | 18 | 38670 | 2449 | 31656207 |
| Hallucination | 17.10 | 14.24 | 106 | 38582 | 46304 | 31612352 |
| Nephrolithiasis | 17.08 | 14.24 | 6 | 38682 | 27333 | 31631323 |
| Hallucination, olfactory | 17.05 | 14.24 | 7 | 38681 | 184 | 31658472 |
| Accidental death | 16.95 | 14.24 | 17 | 38671 | 2200 | 31656456 |
| Stomatitis | 16.86 | 14.24 | 14 | 38674 | 39424 | 31619232 |
| Inappropriate affect | 16.84 | 14.24 | 10 | 38678 | 592 | 31658064 |
| Neutrophilia | 16.70 | 14.24 | 22 | 38666 | 3821 | 31654835 |
| Withdrawal syndrome | 16.49 | 14.24 | 41 | 38647 | 11676 | 31646980 |
| Chest pain | 16.48 | 14.24 | 80 | 38608 | 116877 | 31541779 |
| Off label use | 16.43 | 14.24 | 312 | 38376 | 346962 | 31311694 |
| Hypoaesthesia | 16.31 | 14.24 | 27 | 38661 | 55995 | 31602661 |
| Polydipsia psychogenic | 16.28 | 14.24 | 6 | 38682 | 117 | 31658539 |
| Diabetic coma | 16.15 | 14.24 | 11 | 38677 | 827 | 31657829 |
| Hypertonia | 16.14 | 14.24 | 22 | 38666 | 3946 | 31654710 |
| Long QT syndrome | 16.09 | 14.24 | 17 | 38671 | 2339 | 31656317 |
| Oromandibular dystonia | 16.07 | 14.24 | 9 | 38679 | 477 | 31658179 |
| Thought blocking | 15.91 | 14.24 | 6 | 38682 | 125 | 31658531 |
| Cerebral amyloid angiopathy | 15.87 | 14.24 | 6 | 38682 | 126 | 31658530 |
| Gastrooesophageal reflux disease | 15.79 | 14.24 | 11 | 38677 | 33860 | 31624796 |
| Haematuria | 15.77 | 14.24 | 20 | 38668 | 46294 | 31612362 |
| Lung disorder | 15.73 | 14.24 | 10 | 38678 | 32302 | 31626354 |
| Electrocardiogram T wave amplitude decreased | 15.65 | 14.24 | 7 | 38681 | 228 | 31658428 |
| Toxic encephalopathy | 15.52 | 14.24 | 24 | 38664 | 4826 | 31653830 |
| Neoplasm progression | 15.42 | 14.24 | 3 | 38685 | 20269 | 31638387 |
| Dysphoria | 15.42 | 14.24 | 16 | 38672 | 2156 | 31656500 |
| Platelet count decreased | 15.29 | 14.24 | 76 | 38612 | 110359 | 31548297 |
| Hyperkalaemia | 15.28 | 14.24 | 35 | 38653 | 64316 | 31594340 |
| Gastrectomy | 15.20 | 14.24 | 6 | 38682 | 142 | 31658514 |
| Atrioventricular block first degree | 15.12 | 14.24 | 26 | 38662 | 5711 | 31652945 |
| Wheezing | 15.11 | 14.24 | 13 | 38675 | 35973 | 31622683 |
| Toxic cardiomyopathy | 15.08 | 14.24 | 7 | 38681 | 249 | 31658407 |
| Intention tremor | 14.99 | 14.24 | 8 | 38680 | 385 | 31658271 |
| Oxygen saturation decreased | 14.93 | 14.24 | 23 | 38665 | 49092 | 31609564 |
| Asthma | 14.93 | 14.24 | 18 | 38670 | 42593 | 31616063 |
| Chronic obstructive pulmonary disease | 14.87 | 14.24 | 20 | 38668 | 45146 | 31613510 |
| Acarodermatitis | 14.75 | 14.24 | 8 | 38680 | 398 | 31658258 |
| Bradykinesia | 14.74 | 14.24 | 20 | 38668 | 3572 | 31655084 |
| Psychomotor retardation | 14.72 | 14.24 | 19 | 38669 | 3233 | 31655423 |
| Ascites | 14.71 | 14.24 | 17 | 38671 | 40996 | 31617660 |
| Metastases to eye | 14.66 | 14.24 | 5 | 38683 | 77 | 31658579 |
| Hyperleukocytosis | 14.60 | 14.24 | 14 | 38674 | 1715 | 31656941 |
| Myalgia | 14.60 | 14.24 | 47 | 38641 | 77211 | 31581445 |
| Muscle contractions involuntary | 14.50 | 14.24 | 14 | 38674 | 1730 | 31656926 |
| Rhinorrhoea | 14.47 | 14.24 | 5 | 38683 | 23007 | 31635649 |
| Product dose omission issue | 14.42 | 14.24 | 73 | 38615 | 105513 | 31553143 |
| Sinus arrest | 14.31 | 14.24 | 13 | 38675 | 1488 | 31657168 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Toxicity to various agents | 1998.22 | 13.06 | 2231 | 73139 | 379941 | 70473133 |
| Tremor | 1217.08 | 13.06 | 1132 | 74238 | 154492 | 70698582 |
| Antipsychotic drug level increased | 1196.34 | 13.06 | 375 | 74995 | 5065 | 70848009 |
| Neuroleptic malignant syndrome | 1151.45 | 13.06 | 559 | 74811 | 25448 | 70827626 |
| Nephrogenic diabetes insipidus | 949.06 | 13.06 | 250 | 75120 | 1713 | 70851361 |
| Mania | 851.06 | 13.06 | 399 | 74971 | 16775 | 70836299 |
| Drug interaction | 744.80 | 13.06 | 1398 | 73972 | 380043 | 70473031 |
| Extrapyramidal disorder | 713.33 | 13.06 | 376 | 74994 | 20374 | 70832700 |
| Hypomania | 472.95 | 13.06 | 194 | 75176 | 5878 | 70847196 |
| Antipsychotic drug level above therapeutic | 445.80 | 13.06 | 139 | 75231 | 1840 | 70851234 |
| Agitation | 433.48 | 13.06 | 515 | 74855 | 92860 | 70760214 |
| Psychotic disorder | 427.76 | 13.06 | 340 | 75030 | 37361 | 70815713 |
| Parkinsonism | 392.95 | 13.06 | 229 | 75141 | 15096 | 70837978 |
| Ataxia | 386.82 | 13.06 | 264 | 75106 | 22953 | 70830121 |
| Confusional state | 381.27 | 13.06 | 895 | 74475 | 283503 | 70569571 |
| Serotonin syndrome | 376.63 | 13.06 | 331 | 75039 | 41783 | 70811291 |
| Hyperparathyroidism | 375.69 | 13.06 | 136 | 75234 | 2911 | 70850163 |
| Sopor | 374.14 | 13.06 | 291 | 75079 | 30976 | 70822098 |
| Suicide attempt | 361.51 | 13.06 | 434 | 74936 | 79076 | 70773998 |
| Completed suicide | 349.15 | 13.06 | 755 | 74615 | 226380 | 70626694 |
| Bipolar disorder | 346.94 | 13.06 | 167 | 75203 | 7441 | 70845633 |
| Suicidal ideation | 344.80 | 13.06 | 397 | 74973 | 69199 | 70783875 |
| Dysarthria | 342.11 | 13.06 | 375 | 74995 | 61938 | 70791136 |
| Akathisia | 337.32 | 13.06 | 192 | 75178 | 12101 | 70840973 |
| Schizophrenia | 328.58 | 13.06 | 211 | 75159 | 16557 | 70836517 |
| Sedation | 317.07 | 13.06 | 315 | 75055 | 46416 | 70806658 |
| Tardive dyskinesia | 277.60 | 13.06 | 157 | 75213 | 9772 | 70843302 |
| Salivary hypersecretion | 274.12 | 13.06 | 171 | 75199 | 12754 | 70840320 |
| Pain | 272.71 | 13.06 | 166 | 75204 | 628650 | 70224424 |
| Dyspnoea | 268.09 | 13.06 | 255 | 75115 | 769805 | 70083269 |
| Intentional self-injury | 265.55 | 13.06 | 240 | 75130 | 31410 | 70821664 |
| Rheumatoid arthritis | 256.43 | 13.06 | 13 | 75357 | 291792 | 70561282 |
| Muscle rigidity | 254.98 | 13.06 | 188 | 75182 | 18462 | 70834612 |
| Diabetes insipidus | 251.47 | 13.06 | 115 | 75255 | 4556 | 70848518 |
| Aggression | 251.14 | 13.06 | 283 | 75087 | 48163 | 70804911 |
| Hypernatraemia | 246.12 | 13.06 | 159 | 75211 | 12602 | 70840472 |
| Drug abuse | 238.11 | 13.06 | 500 | 74870 | 146756 | 70706318 |
| Arthralgia | 236.71 | 13.06 | 120 | 75250 | 503270 | 70349804 |
| Granulocytopenia | 236.29 | 13.06 | 145 | 75225 | 10502 | 70842572 |
| Somnolence | 232.38 | 13.06 | 625 | 74745 | 214981 | 70638093 |
| Catatonia | 228.44 | 13.06 | 129 | 75241 | 8004 | 70845070 |
| Psychomotor hyperactivity | 227.87 | 13.06 | 163 | 75207 | 15270 | 70837804 |
| Myoclonus | 227.31 | 13.06 | 203 | 75167 | 26152 | 70826922 |
| Overdose | 222.45 | 13.06 | 530 | 74840 | 169215 | 70683859 |
| Obsessive-compulsive disorder | 215.36 | 13.06 | 108 | 75262 | 5262 | 70847812 |
| Irritability | 199.30 | 13.06 | 224 | 75146 | 38001 | 70815073 |
| Intentional overdose | 196.21 | 13.06 | 365 | 75005 | 98070 | 70755004 |
| Delusion | 192.38 | 13.06 | 161 | 75209 | 19004 | 70834070 |
| Delirium | 192.33 | 13.06 | 310 | 75060 | 74304 | 70778770 |
| Hallucination, auditory | 186.11 | 13.06 | 155 | 75215 | 18173 | 70834901 |
| Disorientation | 180.78 | 13.06 | 263 | 75107 | 57660 | 70795414 |
| Dyskinesia | 179.71 | 13.06 | 220 | 75150 | 40854 | 70812220 |
| Disturbance in attention | 175.26 | 13.06 | 222 | 75148 | 42672 | 70810402 |
| Drug level increased | 157.38 | 13.06 | 194 | 75176 | 36275 | 70816799 |
| Mental status changes | 155.60 | 13.06 | 257 | 75113 | 62844 | 70790230 |
| Infusion related reaction | 150.42 | 13.06 | 17 | 75353 | 197517 | 70655557 |
| Hyperreflexia | 149.13 | 13.06 | 95 | 75275 | 7347 | 70845727 |
| Schizoaffective disorder | 148.61 | 13.06 | 62 | 75308 | 1961 | 70851113 |
| Polyuria | 145.80 | 13.06 | 118 | 75252 | 13288 | 70839786 |
| Coma | 143.87 | 13.06 | 308 | 75062 | 91536 | 70761538 |
| Febrile neutropenia | 142.73 | 13.06 | 23 | 75347 | 204295 | 70648779 |
| Cough | 140.54 | 13.06 | 86 | 75284 | 325291 | 70527783 |
| Hypothyroidism | 138.77 | 13.06 | 205 | 75165 | 45550 | 70807524 |
| Restlessness | 138.34 | 13.06 | 196 | 75174 | 41932 | 70811142 |
| Neurotoxicity | 137.39 | 13.06 | 164 | 75206 | 29662 | 70823412 |
| Speech disorder | 136.98 | 13.06 | 215 | 75155 | 50365 | 70802709 |
| Dystonia | 135.75 | 13.06 | 134 | 75236 | 19572 | 70833502 |
| Altered state of consciousness | 135.58 | 13.06 | 189 | 75181 | 39833 | 70813241 |
| Anaemia | 133.70 | 13.06 | 139 | 75231 | 403284 | 70449790 |
| Joint swelling | 133.56 | 13.06 | 51 | 75319 | 253160 | 70599914 |
| Depressed level of consciousness | 133.27 | 13.06 | 290 | 75080 | 87141 | 70765933 |
| Electrocardiogram QT prolonged | 129.56 | 13.06 | 279 | 75091 | 83238 | 70769836 |
| Antipsychotic drug level below therapeutic | 129.08 | 13.06 | 46 | 75324 | 939 | 70852135 |
| Abnormal behaviour | 125.24 | 13.06 | 169 | 75201 | 34540 | 70818534 |
| Hypersensitivity | 125.06 | 13.06 | 44 | 75326 | 229768 | 70623306 |
| Pruritus | 125.04 | 13.06 | 110 | 75260 | 345450 | 70507624 |
| Polydipsia | 123.88 | 13.06 | 78 | 75292 | 5910 | 70847164 |
| Synovitis | 122.97 | 13.06 | 3 | 75367 | 129225 | 70723849 |
| Pain in extremity | 115.63 | 13.06 | 107 | 75263 | 327975 | 70525099 |
| Weight increased | 114.22 | 13.06 | 535 | 74835 | 241796 | 70611278 |
| Peripheral swelling | 111.54 | 13.06 | 56 | 75314 | 236507 | 70616567 |
| Pleurothotonus | 111.09 | 13.06 | 53 | 75317 | 2313 | 70850761 |
| Cognitive disorder | 110.28 | 13.06 | 217 | 75153 | 60739 | 70792335 |
| Depression | 110.19 | 13.06 | 461 | 74909 | 198513 | 70654561 |
| Swelling | 109.84 | 13.06 | 32 | 75338 | 188507 | 70664567 |
| Brugada syndrome | 108.76 | 13.06 | 42 | 75328 | 1081 | 70851993 |
| Back pain | 104.63 | 13.06 | 81 | 75289 | 271071 | 70582003 |
| Fatigue | 104.07 | 13.06 | 487 | 74883 | 823832 | 70029242 |
| Cerebellar syndrome | 102.89 | 13.06 | 66 | 75304 | 5165 | 70847909 |
| Bradyphrenia | 102.81 | 13.06 | 85 | 75285 | 9861 | 70843213 |
| Arthropathy | 102.32 | 13.06 | 18 | 75352 | 150039 | 70703035 |
| Disease progression | 102.15 | 13.06 | 21 | 75349 | 156651 | 70696423 |
| Blood creatine phosphokinase increased | 101.19 | 13.06 | 210 | 75160 | 61053 | 70792021 |
| Rash | 100.97 | 13.06 | 248 | 75122 | 510314 | 70342760 |
| Euphoric mood | 99.94 | 13.06 | 72 | 75298 | 6817 | 70846257 |
| Bruxism | 98.95 | 13.06 | 57 | 75313 | 3672 | 70849402 |
| Sinusitis | 98.03 | 13.06 | 29 | 75341 | 169166 | 70683908 |
| Nasopharyngitis | 96.91 | 13.06 | 58 | 75312 | 222148 | 70630926 |
| Malignant neoplasm progression | 96.47 | 13.06 | 9 | 75361 | 121730 | 70731344 |
| White blood cell count increased | 95.08 | 13.06 | 221 | 75149 | 69352 | 70783722 |
| Nephropathy | 94.53 | 13.06 | 77 | 75293 | 8748 | 70844326 |
| Logorrhoea | 91.20 | 13.06 | 56 | 75314 | 4058 | 70849016 |
| Systemic lupus erythematosus | 91.16 | 13.06 | 4 | 75366 | 101898 | 70751176 |
| Bipolar I disorder | 90.19 | 13.06 | 43 | 75327 | 1874 | 70851200 |
| Apathy | 89.59 | 13.06 | 85 | 75285 | 11823 | 70841251 |
| Encephalopathy | 88.83 | 13.06 | 200 | 75170 | 61461 | 70791613 |
| Treatment noncompliance | 88.14 | 13.06 | 169 | 75201 | 46405 | 70806669 |
| Leukocytosis | 87.77 | 13.06 | 154 | 75216 | 39514 | 70813560 |
| Alopecia | 87.69 | 13.06 | 51 | 75319 | 198439 | 70654635 |
| Atrial fibrillation | 84.85 | 13.06 | 45 | 75325 | 184303 | 70668771 |
| Neutrophil count increased | 84.05 | 13.06 | 122 | 75248 | 26673 | 70826401 |
| Priapism | 83.68 | 13.06 | 53 | 75317 | 4057 | 70849017 |
| Drug intolerance | 82.59 | 13.06 | 71 | 75299 | 225616 | 70627458 |
| Death | 82.26 | 13.06 | 273 | 75097 | 509788 | 70343286 |
| Camptocormia | 80.62 | 13.06 | 27 | 75343 | 454 | 70852620 |
| Stomatitis | 80.18 | 13.06 | 19 | 75351 | 128492 | 70724582 |
| Anxiety | 79.78 | 13.06 | 452 | 74918 | 219878 | 70633196 |
| Jaundice cholestatic | 79.68 | 13.06 | 71 | 75299 | 9113 | 70843961 |
| Interstitial lung disease | 79.68 | 13.06 | 9 | 75361 | 104676 | 70748398 |
| Grandiosity | 79.48 | 13.06 | 28 | 75342 | 552 | 70852522 |
| Pneumonia | 79.43 | 13.06 | 345 | 75025 | 595887 | 70257187 |
| Hypercalcaemia | 79.35 | 13.06 | 136 | 75234 | 34249 | 70818825 |
| Depressed mood | 79.25 | 13.06 | 156 | 75214 | 43664 | 70809410 |
| Hand deformity | 78.68 | 13.06 | 3 | 75367 | 86479 | 70766595 |
| Enuresis | 78.50 | 13.06 | 45 | 75325 | 2872 | 70850202 |
| Cogwheel rigidity | 77.78 | 13.06 | 45 | 75325 | 2923 | 70850151 |
| Coordination abnormal | 76.72 | 13.06 | 90 | 75280 | 15976 | 70837098 |
| Contraindicated product administered | 76.29 | 13.06 | 24 | 75346 | 134588 | 70718486 |
| Infection | 76.29 | 13.06 | 67 | 75303 | 210718 | 70642356 |
| Libido increased | 76.15 | 13.06 | 38 | 75332 | 1831 | 70851243 |
| Oppositional defiant disorder | 75.89 | 13.06 | 26 | 75344 | 470 | 70852604 |
| Poisoning deliberate | 75.60 | 13.06 | 92 | 75278 | 16968 | 70836106 |
| Mutism | 74.54 | 13.06 | 39 | 75331 | 2077 | 70850997 |
| Renal cyst | 74.36 | 13.06 | 81 | 75289 | 13264 | 70839810 |
| Clonus | 74.20 | 13.06 | 58 | 75312 | 6210 | 70846864 |
| Affect lability | 73.63 | 13.06 | 71 | 75299 | 10075 | 70842999 |
| Mental disorder | 73.63 | 13.06 | 118 | 75252 | 28122 | 70824952 |
| Cardiac failure congestive | 73.54 | 13.06 | 26 | 75344 | 135431 | 70717643 |
| Arthritis | 73.14 | 13.06 | 9 | 75361 | 97971 | 70755103 |
| Homicidal ideation | 73.07 | 13.06 | 45 | 75325 | 3278 | 70849796 |
| Paranoia | 73.02 | 13.06 | 91 | 75279 | 17197 | 70835877 |
| Glossodynia | 72.40 | 13.06 | 5 | 75365 | 86482 | 70766592 |
| Choreoathetosis | 71.30 | 13.06 | 34 | 75336 | 1482 | 70851592 |
| Parathyroid tumour benign | 70.10 | 13.06 | 27 | 75343 | 690 | 70852384 |
| Headache | 70.09 | 13.06 | 348 | 75022 | 580057 | 70273017 |
| Poisoning | 69.50 | 13.06 | 102 | 75268 | 22520 | 70830554 |
| Withdrawal syndrome | 68.99 | 13.06 | 107 | 75263 | 24797 | 70828277 |
| Body tinea | 68.06 | 13.06 | 32 | 75338 | 1351 | 70851723 |
| Pericarditis | 67.81 | 13.06 | 6 | 75364 | 84699 | 70768375 |
| Gastrointestinal haemorrhage | 67.06 | 13.06 | 31 | 75339 | 137377 | 70715697 |
| Wound | 66.95 | 13.06 | 12 | 75358 | 98720 | 70754354 |
| Aphasia | 65.34 | 13.06 | 143 | 75227 | 43106 | 70809968 |
| Electroencephalogram abnormal | 65.18 | 13.06 | 50 | 75320 | 5208 | 70847866 |
| Bradykinesia | 65.09 | 13.06 | 58 | 75312 | 7444 | 70845630 |
| Urticaria | 65.05 | 13.06 | 47 | 75323 | 163002 | 70690072 |
| Hyperparathyroidism primary | 64.56 | 13.06 | 22 | 75348 | 391 | 70852683 |
| Abdominal discomfort | 64.43 | 13.06 | 80 | 75290 | 214578 | 70638496 |
| Hyperprolactinaemia | 63.74 | 13.06 | 46 | 75324 | 4367 | 70848707 |
| Intentional product use issue | 63.62 | 13.06 | 24 | 75346 | 120118 | 70732956 |
| Insomnia | 62.57 | 13.06 | 421 | 74949 | 217385 | 70635689 |
| Decreased eye contact | 62.50 | 13.06 | 26 | 75344 | 816 | 70852258 |
| Pyramidal tract syndrome | 62.06 | 13.06 | 23 | 75347 | 527 | 70852547 |
| Increased appetite | 61.91 | 13.06 | 66 | 75304 | 10547 | 70842527 |
| Stupor | 61.86 | 13.06 | 53 | 75317 | 6456 | 70846618 |
| Thinking abnormal | 61.73 | 13.06 | 70 | 75300 | 11981 | 70841093 |
| Drooling | 61.55 | 13.06 | 49 | 75321 | 5387 | 70847687 |
| Sepsis | 59.87 | 13.06 | 105 | 75265 | 244440 | 70608634 |
| Drug level above therapeutic | 59.65 | 13.06 | 56 | 75314 | 7686 | 70845388 |
| Psychiatric decompensation | 59.52 | 13.06 | 38 | 75332 | 2949 | 70850125 |
| Thrombocytopenia | 59.14 | 13.06 | 102 | 75268 | 239008 | 70614066 |
| Postural tremor | 58.98 | 13.06 | 23 | 75347 | 608 | 70852466 |
| Gait disturbance | 57.54 | 13.06 | 365 | 75005 | 184741 | 70668333 |
| Abdominal pain | 57.24 | 13.06 | 180 | 75190 | 341947 | 70511127 |
| Chronic kidney disease | 56.79 | 13.06 | 168 | 75202 | 60889 | 70792185 |
| General physical health deterioration | 56.29 | 13.06 | 103 | 75267 | 235928 | 70617146 |
| Hostility | 55.95 | 13.06 | 33 | 75337 | 2222 | 70850852 |
| Disinhibition | 55.33 | 13.06 | 33 | 75337 | 2268 | 70850806 |
| Myocarditis | 55.24 | 13.06 | 83 | 75287 | 18710 | 70834364 |
| Diarrhoea | 55.02 | 13.06 | 550 | 74820 | 782791 | 70070283 |
| Asthma | 54.81 | 13.06 | 30 | 75340 | 120763 | 70732311 |
| Neuropathy peripheral | 54.07 | 13.06 | 34 | 75336 | 126862 | 70726212 |
| Plasma cell myeloma | 53.96 | 13.06 | 7 | 75363 | 73194 | 70779880 |
| Leukopenia | 53.63 | 13.06 | 240 | 75130 | 106320 | 70746754 |
| Therapeutic product effect decreased | 53.51 | 13.06 | 44 | 75326 | 142974 | 70710100 |
| Drug reaction with eosinophilia and systemic symptoms | 53.36 | 13.06 | 159 | 75211 | 57854 | 70795220 |
| Myocardial infarction | 52.52 | 13.06 | 63 | 75307 | 171582 | 70681492 |
| Hypertonia | 51.99 | 13.06 | 48 | 75322 | 6450 | 70846624 |
| Bronchitis | 51.93 | 13.06 | 30 | 75340 | 117213 | 70735861 |
| Lethargy | 51.91 | 13.06 | 187 | 75183 | 75063 | 70778011 |
| Blister | 51.71 | 13.06 | 21 | 75349 | 100505 | 70752569 |
| Anger | 51.39 | 13.06 | 74 | 75296 | 16058 | 70837016 |
| Chest pain | 51.17 | 13.06 | 120 | 75250 | 251140 | 70601934 |
| Pressure of speech | 51.09 | 13.06 | 24 | 75346 | 1011 | 70852063 |
| Persistent depressive disorder | 50.96 | 13.06 | 24 | 75346 | 1017 | 70852057 |
| Impaired healing | 50.51 | 13.06 | 9 | 75361 | 74365 | 70778709 |
| Poor quality sleep | 50.29 | 13.06 | 83 | 75287 | 20266 | 70832808 |
| Glucose tolerance impaired | 50.09 | 13.06 | 48 | 75322 | 6758 | 70846316 |
| Anticholinergic syndrome | 49.88 | 13.06 | 34 | 75336 | 2946 | 70850128 |
| Blood prolactin increased | 49.41 | 13.06 | 37 | 75333 | 3717 | 70849357 |
| Acute kidney injury | 49.20 | 13.06 | 742 | 74628 | 473882 | 70379192 |
| Injection site erythema | 49.15 | 13.06 | 9 | 75361 | 72915 | 70780159 |
| Dystonic tremor | 48.70 | 13.06 | 15 | 75355 | 190 | 70852884 |
| Abdominal pain upper | 48.40 | 13.06 | 82 | 75288 | 193520 | 70659554 |
| Treatment failure | 48.39 | 13.06 | 49 | 75321 | 144093 | 70708981 |
| Galactorrhoea | 48.30 | 13.06 | 35 | 75335 | 3343 | 70849731 |
| Urinary incontinence | 48.21 | 13.06 | 117 | 75253 | 37725 | 70815349 |
| Blood sodium increased | 48.01 | 13.06 | 39 | 75331 | 4413 | 70848661 |
| Major depression | 47.70 | 13.06 | 52 | 75318 | 8522 | 70844552 |
| Mental impairment | 47.60 | 13.06 | 74 | 75296 | 17181 | 70835893 |
| Gestational diabetes | 47.37 | 13.06 | 44 | 75326 | 5957 | 70847117 |
| Depressive symptom | 46.84 | 13.06 | 41 | 75329 | 5140 | 70847934 |
| Hyperthermia | 46.70 | 13.06 | 72 | 75298 | 16599 | 70836475 |
| Musculoskeletal pain | 46.25 | 13.06 | 19 | 75351 | 90308 | 70762766 |
| Distractibility | 45.90 | 13.06 | 20 | 75350 | 705 | 70852369 |
| Schizoaffective disorder bipolar type | 45.62 | 13.06 | 14 | 75356 | 175 | 70852899 |
| Psychiatric symptom | 45.42 | 13.06 | 45 | 75325 | 6599 | 70846475 |
| Infection susceptibility increased | 45.41 | 13.06 | 32 | 75338 | 2925 | 70850149 |
| Bundle branch block right | 45.05 | 13.06 | 56 | 75314 | 10554 | 70842520 |
| Behaviour disorder | 44.96 | 13.06 | 41 | 75329 | 5423 | 70847651 |
| Pancytopenia | 44.61 | 13.06 | 57 | 75313 | 151050 | 70702024 |
| Inhibitory drug interaction | 44.57 | 13.06 | 35 | 75335 | 3772 | 70849302 |
| Mucosal inflammation | 44.40 | 13.06 | 9 | 75361 | 67841 | 70785233 |
| Ascites | 44.12 | 13.06 | 9 | 75361 | 67538 | 70785536 |
| Muscle contractions involuntary | 44.04 | 13.06 | 33 | 75337 | 3318 | 70849756 |
| Electroconvulsive therapy | 44.02 | 13.06 | 12 | 75358 | 95 | 70852979 |
| Muscle twitching | 43.88 | 13.06 | 77 | 75293 | 19750 | 70833324 |
| Psoriatic arthropathy | 43.63 | 13.06 | 8 | 75362 | 64763 | 70788311 |
| Metabolic syndrome | 43.24 | 13.06 | 29 | 75341 | 2446 | 70850628 |
| Balance disorder | 43.11 | 13.06 | 200 | 75170 | 89928 | 70763146 |
| International normalised ratio increased | 42.95 | 13.06 | 16 | 75354 | 80710 | 70772364 |
| Cardio-respiratory arrest | 42.83 | 13.06 | 216 | 75154 | 100461 | 70752613 |
| Productive cough | 42.57 | 13.06 | 15 | 75355 | 78322 | 70774752 |
| Drug hypersensitivity | 42.54 | 13.06 | 140 | 75230 | 262319 | 70590755 |
| Renal oncocytoma | 42.44 | 13.06 | 11 | 75359 | 70 | 70853004 |
| Tachycardia | 42.27 | 13.06 | 301 | 75069 | 158245 | 70694829 |
| Hyperthyroidism | 41.87 | 13.06 | 76 | 75294 | 20015 | 70833059 |
| Action tremor | 41.68 | 13.06 | 16 | 75354 | 405 | 70852669 |
| Delusion of grandeur | 41.62 | 13.06 | 20 | 75350 | 887 | 70852187 |
| Hallucination | 41.60 | 13.06 | 176 | 75194 | 76084 | 70776990 |
| Trismus | 41.49 | 13.06 | 38 | 75332 | 5053 | 70848021 |
| Gastrointestinal disorder | 41.25 | 13.06 | 31 | 75339 | 105396 | 70747678 |
| Electrocardiogram T wave abnormal | 41.07 | 13.06 | 32 | 75338 | 3410 | 70849664 |
| Abulia | 41.04 | 13.06 | 20 | 75350 | 915 | 70852159 |
| Mobility decreased | 40.66 | 13.06 | 30 | 75340 | 102969 | 70750105 |
| Hypothermia | 40.52 | 13.06 | 76 | 75294 | 20518 | 70832556 |
| Mood altered | 40.44 | 13.06 | 67 | 75303 | 16408 | 70836666 |
| Blunted affect | 40.44 | 13.06 | 16 | 75354 | 440 | 70852634 |
| Oedema peripheral | 40.27 | 13.06 | 117 | 75253 | 227974 | 70625100 |
| Osteoarthritis | 38.94 | 13.06 | 15 | 75355 | 74132 | 70778942 |
| Asterixis | 38.77 | 13.06 | 27 | 75343 | 2422 | 70850652 |
| Sexually inappropriate behaviour | 38.56 | 13.06 | 16 | 75354 | 499 | 70852575 |
| Resting tremor | 38.38 | 13.06 | 22 | 75348 | 1404 | 70851670 |
| Pleural effusion | 38.31 | 13.06 | 51 | 75319 | 132813 | 70720261 |
| Miosis | 38.24 | 13.06 | 60 | 75310 | 14041 | 70839033 |
| Visuospatial deficit | 38.19 | 13.06 | 9 | 75361 | 36 | 70853038 |
| Electrocardiogram T wave inversion | 38.01 | 13.06 | 36 | 75334 | 4995 | 70848079 |
| Melaena | 37.88 | 13.06 | 7 | 75363 | 56348 | 70796726 |
| Cerebellar atrophy | 37.86 | 13.06 | 20 | 75350 | 1086 | 70851988 |
| Haemodialysis | 37.86 | 13.06 | 67 | 75303 | 17299 | 70835775 |
| Acute myocardial infarction | 37.85 | 13.06 | 15 | 75355 | 72872 | 70780202 |
| Malaise | 37.83 | 13.06 | 287 | 75083 | 432645 | 70420429 |
| Haemorrhage | 37.75 | 13.06 | 21 | 75349 | 83794 | 70769280 |
| Agranulocytosis | 37.58 | 13.06 | 111 | 75259 | 40187 | 70812887 |
| Affective disorder | 37.56 | 13.06 | 43 | 75327 | 7436 | 70845638 |
| Cerebrovascular accident | 37.50 | 13.06 | 59 | 75311 | 143411 | 70709663 |
| Memory impairment | 37.48 | 13.06 | 196 | 75174 | 92445 | 70760629 |
| Failure to suspend medication | 37.10 | 13.06 | 15 | 75355 | 437 | 70852637 |
| Psychomotor skills impaired | 36.93 | 13.06 | 33 | 75337 | 4251 | 70848823 |
| Personality disorder | 36.86 | 13.06 | 37 | 75333 | 5511 | 70847563 |
| Cardiac failure | 36.61 | 13.06 | 60 | 75310 | 143481 | 70709593 |
| Lung disorder | 36.58 | 13.06 | 14 | 75356 | 69470 | 70783604 |
| Electrocardiogram abnormal | 36.49 | 13.06 | 60 | 75310 | 14604 | 70838470 |
| Oculogyric crisis | 36.42 | 13.06 | 27 | 75343 | 2671 | 70850403 |
| Hypokinesia | 36.40 | 13.06 | 66 | 75304 | 17366 | 70835708 |
| Long QT syndrome | 36.27 | 13.06 | 36 | 75334 | 5291 | 70847783 |
| Pneumonitis | 36.23 | 13.06 | 7 | 75363 | 54590 | 70798484 |
| Septic shock | 35.62 | 13.06 | 40 | 75330 | 112218 | 70740856 |
| Rhinorrhoea | 35.57 | 13.06 | 13 | 75357 | 66358 | 70786716 |
| Epistaxis | 35.47 | 13.06 | 34 | 75336 | 102593 | 70750481 |
| Persecutory delusion | 35.43 | 13.06 | 33 | 75337 | 4484 | 70848590 |
| Antipsychotic drug level decreased | 35.38 | 13.06 | 19 | 75351 | 1067 | 70852007 |
| Discomfort | 35.21 | 13.06 | 36 | 75334 | 105400 | 70747674 |
| Anaphylactic reaction | 34.92 | 13.06 | 18 | 75352 | 74956 | 70778118 |
| Psychomotor retardation | 34.77 | 13.06 | 36 | 75334 | 5562 | 70847512 |
| Soft tissue injury | 34.54 | 13.06 | 22 | 75348 | 1700 | 70851374 |
| Blood pressure fluctuation | 34.37 | 13.06 | 10 | 75360 | 59002 | 70794072 |
| Lower respiratory tract infection | 34.30 | 13.06 | 41 | 75329 | 111872 | 70741202 |
| Electrocardiogram QRS complex prolonged | 34.23 | 13.06 | 47 | 75323 | 9759 | 70843315 |
| Language disorder | 34.19 | 13.06 | 27 | 75343 | 2934 | 70850140 |
| Injection site pain | 34.06 | 13.06 | 45 | 75325 | 117574 | 70735500 |
| Impulsive behaviour | 33.72 | 13.06 | 26 | 75344 | 2728 | 70850346 |
| Sleep-related eating disorder | 33.65 | 13.06 | 16 | 75354 | 693 | 70852381 |
| Feeling guilty | 33.59 | 13.06 | 17 | 75353 | 844 | 70852230 |
| Goitre | 33.50 | 13.06 | 34 | 75336 | 5132 | 70847942 |
| Acute psychosis | 33.43 | 13.06 | 30 | 75340 | 3886 | 70849188 |
| Dyspnoea exertional | 33.42 | 13.06 | 21 | 75349 | 78409 | 70774665 |
| Self-injurious ideation | 33.40 | 13.06 | 28 | 75342 | 3310 | 70849764 |
| Platelet count decreased | 33.24 | 13.06 | 89 | 75281 | 178133 | 70674941 |
| Otospondylomegaepiphyseal dysplasia | 33.01 | 13.06 | 8 | 75362 | 37 | 70853037 |
| Sluggishness | 32.98 | 13.06 | 36 | 75334 | 5907 | 70847167 |
| Social avoidant behaviour | 32.69 | 13.06 | 32 | 75338 | 4624 | 70848450 |
| Hyperkinesia | 32.64 | 13.06 | 25 | 75345 | 2598 | 70850476 |
| Restless legs syndrome | 32.58 | 13.06 | 65 | 75305 | 18363 | 70834711 |
| Nausea | 32.55 | 13.06 | 675 | 74695 | 851413 | 70001661 |
| Hypomagnesaemia | 32.32 | 13.06 | 3 | 75367 | 40761 | 70812313 |
| Feelings of worthlessness | 32.31 | 13.06 | 14 | 75356 | 487 | 70852587 |
| Nodal rhythm | 32.21 | 13.06 | 26 | 75344 | 2915 | 70850159 |
| Decreased appetite | 32.13 | 13.06 | 191 | 75179 | 304589 | 70548485 |
| Fibromyalgia | 32.06 | 13.06 | 6 | 75364 | 47868 | 70805206 |
| Blood thyroid stimulating hormone decreased | 31.96 | 13.06 | 34 | 75336 | 5420 | 70847654 |
| Neoplasm progression | 31.76 | 13.06 | 5 | 75365 | 45223 | 70807851 |
| Erythema | 31.26 | 13.06 | 108 | 75262 | 199455 | 70653619 |
| Product use issue | 31.24 | 13.06 | 93 | 75277 | 179844 | 70673230 |
| Adams-Stokes syndrome | 31.16 | 13.06 | 10 | 75360 | 146 | 70852928 |
| Muscle spasms | 31.00 | 13.06 | 74 | 75296 | 153972 | 70699102 |
| Coronary artery disease | 30.83 | 13.06 | 14 | 75356 | 62722 | 70790352 |
| Patient restraint | 30.63 | 13.06 | 9 | 75361 | 96 | 70852978 |
| Speech sound disorder | 30.59 | 13.06 | 8 | 75362 | 53 | 70853021 |
| Neutrophilia | 30.47 | 13.06 | 38 | 75332 | 7183 | 70845891 |
| Differential white blood cell count abnormal | 30.32 | 13.06 | 21 | 75349 | 1867 | 70851207 |
| Protein C increased | 30.13 | 13.06 | 9 | 75361 | 102 | 70852972 |
| Sinus bradycardia | 30.05 | 13.06 | 73 | 75297 | 23550 | 70829524 |
| Paraesthesia | 30.01 | 13.06 | 69 | 75301 | 145468 | 70707606 |
| Apraxia | 29.98 | 13.06 | 24 | 75346 | 2659 | 70850415 |
| Oncocytoma | 29.90 | 13.06 | 7 | 75363 | 27 | 70853047 |
| Dysphemia | 29.85 | 13.06 | 26 | 75344 | 3237 | 70849837 |
| Hallucination, olfactory | 29.84 | 13.06 | 13 | 75357 | 458 | 70852616 |
| Tachyphrenia | 29.70 | 13.06 | 21 | 75349 | 1930 | 70851144 |
| Post-traumatic neck syndrome | 29.49 | 13.06 | 21 | 75349 | 1952 | 70851122 |
| Wheezing | 29.39 | 13.06 | 34 | 75336 | 94136 | 70758938 |
| Hyporeflexia | 29.28 | 13.06 | 26 | 75344 | 3321 | 70849753 |
| Urinary retention | 29.25 | 13.06 | 122 | 75248 | 52398 | 70800676 |
| Echolalia | 29.11 | 13.06 | 12 | 75358 | 368 | 70852706 |
| Upper gastrointestinal haemorrhage | 29.08 | 13.06 | 3 | 75367 | 37474 | 70815600 |
| Metabolic encephalopathy | 29.07 | 13.06 | 40 | 75330 | 8323 | 70844751 |
| Chest discomfort | 28.99 | 13.06 | 55 | 75315 | 124326 | 70728748 |
| Haematoma | 28.57 | 13.06 | 8 | 75362 | 48410 | 70804664 |
| Drug withdrawal syndrome | 28.51 | 13.06 | 88 | 75282 | 32627 | 70820447 |
| Hyperhidrosis | 28.48 | 13.06 | 238 | 75132 | 131348 | 70721726 |
| Skin ulcer | 28.33 | 13.06 | 8 | 75362 | 48137 | 70804937 |
| Respiratory arrest | 28.28 | 13.06 | 123 | 75247 | 53810 | 70799264 |
| Haemoglobin decreased | 28.26 | 13.06 | 117 | 75253 | 205042 | 70648032 |
| Psoriasis | 28.15 | 13.06 | 38 | 75332 | 98395 | 70754679 |
| Dysphoria | 28.07 | 13.06 | 29 | 75341 | 4469 | 70848605 |
| Antipsychotic drug level | 27.88 | 13.06 | 6 | 75364 | 14 | 70853060 |
| Parkinsonian gait | 27.82 | 13.06 | 15 | 75355 | 849 | 70852225 |
| Osteonecrosis of jaw | 27.76 | 13.06 | 5 | 75365 | 40997 | 70812077 |
| Papillary thyroid cancer | 27.64 | 13.06 | 22 | 75348 | 2418 | 70850656 |
| Influenza | 27.63 | 13.06 | 49 | 75321 | 113651 | 70739423 |
| Hyperleukocytosis | 27.43 | 13.06 | 21 | 75349 | 2180 | 70850894 |
| Poverty of speech | 27.28 | 13.06 | 13 | 75357 | 566 | 70852508 |
| Thrombosis | 27.21 | 13.06 | 24 | 75346 | 75381 | 70777693 |
| Bone pain | 27.15 | 13.06 | 10 | 75360 | 50812 | 70802262 |
| COVID-19 | 27.15 | 13.06 | 44 | 75326 | 105713 | 70747361 |
| Off label use | 27.06 | 13.06 | 593 | 74777 | 742467 | 70110607 |
| Sleep disorder | 27.01 | 13.06 | 146 | 75224 | 69726 | 70783348 |
| Movement disorder | 26.97 | 13.06 | 71 | 75299 | 24058 | 70829016 |
| Convulsive threshold lowered | 26.88 | 13.06 | 15 | 75355 | 909 | 70852165 |
| Angina pectoris | 26.74 | 13.06 | 9 | 75361 | 48374 | 70804700 |
| Hypoxia | 26.73 | 13.06 | 36 | 75334 | 93308 | 70759766 |
| Seizure | 26.71 | 13.06 | 298 | 75072 | 177664 | 70675410 |
| Upper respiratory tract infection | 26.54 | 13.06 | 27 | 75343 | 79247 | 70773827 |
| Toxic encephalopathy | 26.46 | 13.06 | 43 | 75327 | 10363 | 70842711 |
| Blood pressure increased | 26.28 | 13.06 | 107 | 75263 | 188410 | 70664664 |
| Sternal fracture | 26.21 | 13.06 | 21 | 75349 | 2330 | 70850744 |
| Sinus arrest | 26.21 | 13.06 | 24 | 75346 | 3191 | 70849883 |
| Haemoptysis | 26.05 | 13.06 | 11 | 75359 | 51441 | 70801633 |
| Deprescribing error | 25.87 | 13.06 | 6 | 75364 | 22 | 70853052 |
| Oxygen saturation decreased | 25.82 | 13.06 | 53 | 75317 | 116376 | 70736698 |
| Acquired cystic kidney disease | 25.73 | 13.06 | 7 | 75363 | 55 | 70853019 |
| Injection site swelling | 25.71 | 13.06 | 7 | 75363 | 43150 | 70809924 |
| Nystagmus | 25.64 | 13.06 | 40 | 75330 | 9315 | 70843759 |
| Hypoaesthesia | 25.59 | 13.06 | 81 | 75289 | 153658 | 70699416 |
| Hyperammonaemia | 25.45 | 13.06 | 42 | 75328 | 10251 | 70842823 |
| Gaze palsy | 25.42 | 13.06 | 22 | 75348 | 2716 | 70850358 |
| Antidepressant drug level increased | 25.14 | 13.06 | 11 | 75359 | 392 | 70852682 |
| Induced abortion failed | 25.06 | 13.06 | 9 | 75361 | 188 | 70852886 |
| Inflammation | 24.99 | 13.06 | 28 | 75342 | 78637 | 70774437 |
| Cerebral haemorrhage | 24.98 | 13.06 | 13 | 75357 | 53851 | 70799223 |
| Neurological symptom | 24.86 | 13.06 | 35 | 75335 | 7438 | 70845636 |
| Staphylococcal infection | 24.60 | 13.06 | 13 | 75357 | 53391 | 70799683 |
| Hereditary ataxia | 24.54 | 13.06 | 6 | 75364 | 29 | 70853045 |
| Diverticulitis | 24.43 | 13.06 | 7 | 75363 | 41727 | 70811347 |
| Nephropathy toxic | 24.39 | 13.06 | 58 | 75312 | 18456 | 70834618 |
| Fluid retention | 24.33 | 13.06 | 19 | 75351 | 63366 | 70789708 |
| Status epilepticus | 24.26 | 13.06 | 69 | 75301 | 24457 | 70828617 |
| Electric shock sensation | 23.88 | 13.06 | 12 | 75358 | 587 | 70852487 |
| Myocarditis septic | 23.45 | 13.06 | 6 | 75364 | 36 | 70853038 |
| Crying | 23.31 | 13.06 | 62 | 75308 | 21137 | 70831937 |
| Flat affect | 23.21 | 13.06 | 18 | 75352 | 1905 | 70851169 |
| Chronic obstructive pulmonary disease | 23.20 | 13.06 | 29 | 75341 | 77612 | 70775462 |
| Blood creatinine increased | 23.09 | 13.06 | 243 | 75127 | 142758 | 70710316 |
| Gambling disorder | 23.09 | 13.06 | 18 | 75352 | 1920 | 70851154 |
| Injection site bruising | 22.98 | 13.06 | 6 | 75364 | 38026 | 70815048 |
| Hallucinations, mixed | 22.97 | 13.06 | 31 | 75339 | 6331 | 70846743 |
| Substance abuse | 22.81 | 13.06 | 39 | 75331 | 9798 | 70843276 |
| Gastric disorder | 22.69 | 13.06 | 4 | 75366 | 33318 | 70819756 |
| Conversion disorder | 22.50 | 13.06 | 17 | 75353 | 1731 | 70851343 |
| Osteomyelitis | 22.10 | 13.06 | 3 | 75367 | 30315 | 70822759 |
| Lactic acidosis | 21.93 | 13.06 | 22 | 75348 | 65002 | 70788072 |
| Cholelithiasis | 21.86 | 13.06 | 104 | 75266 | 47236 | 70805838 |
| Sexual dysfunction | 21.80 | 13.06 | 31 | 75339 | 6650 | 70846424 |
| Mydriasis | 21.71 | 13.06 | 51 | 75319 | 16102 | 70836972 |
| Progressive supranuclear palsy | 21.70 | 13.06 | 7 | 75363 | 104 | 70852970 |
| Cerebellar ataxia | 21.69 | 13.06 | 17 | 75353 | 1827 | 70851247 |
| Drug level decreased | 21.69 | 13.06 | 44 | 75326 | 12580 | 70840494 |
| Mood swings | 21.67 | 13.06 | 55 | 75315 | 18231 | 70834843 |
| Knee arthroplasty | 21.52 | 13.06 | 5 | 75365 | 34296 | 70818778 |
| Thought blocking | 21.32 | 13.06 | 8 | 75362 | 190 | 70852884 |
| Flight of ideas | 21.25 | 13.06 | 12 | 75358 | 744 | 70852330 |
| Haematochezia | 21.11 | 13.06 | 28 | 75342 | 73053 | 70780021 |
| Water intoxication | 21.06 | 13.06 | 12 | 75358 | 757 | 70852317 |
| Haematuria | 20.89 | 13.06 | 22 | 75348 | 63551 | 70789523 |
| Clostridium difficile colitis | 20.83 | 13.06 | 3 | 75367 | 28993 | 70824081 |
| Cystitis | 20.79 | 13.06 | 12 | 75358 | 46929 | 70806145 |
| Medication error | 20.71 | 13.06 | 117 | 75253 | 56795 | 70796279 |
| Eosinophil count decreased | 20.69 | 13.06 | 20 | 75350 | 2846 | 70850228 |
| Prostate cancer | 20.67 | 13.06 | 4 | 75366 | 31159 | 70821915 |
| Ileus paralytic | 20.67 | 13.06 | 35 | 75335 | 8726 | 70844348 |
| Negativism | 20.54 | 13.06 | 12 | 75358 | 794 | 70852280 |
| Hypokalaemia | 20.53 | 13.06 | 71 | 75299 | 131117 | 70721957 |
| Throat irritation | 20.52 | 13.06 | 6 | 75364 | 35298 | 70817776 |
| Localised infection | 20.48 | 13.06 | 5 | 75365 | 33153 | 70819921 |
| Encopresis | 20.46 | 13.06 | 7 | 75363 | 126 | 70852948 |
| Suspected suicide | 20.45 | 13.06 | 35 | 75335 | 8799 | 70844275 |
| Clear cell renal cell carcinoma | 20.32 | 13.06 | 18 | 75352 | 2292 | 70850782 |
| Ear infection | 20.20 | 13.06 | 3 | 75367 | 28333 | 70824741 |
| Reflexes abnormal | 20.18 | 13.06 | 12 | 75358 | 820 | 70852254 |
| Weight decreased | 20.05 | 13.06 | 222 | 75148 | 310266 | 70542808 |
| Myelosuppression | 19.72 | 13.06 | 4 | 75366 | 30141 | 70822933 |
| Delusion of reference | 19.64 | 13.06 | 7 | 75363 | 143 | 70852931 |
| Oropharyngeal pain | 19.58 | 13.06 | 46 | 75324 | 96264 | 70756810 |
| Bipolar II disorder | 19.39 | 13.06 | 9 | 75361 | 369 | 70852705 |
| Lactate pyruvate ratio increased | 19.27 | 13.06 | 6 | 75364 | 79 | 70852995 |
| Atrioventricular block first degree | 19.24 | 13.06 | 40 | 75330 | 11633 | 70841441 |
| Ideas of reference | 19.15 | 13.06 | 7 | 75363 | 154 | 70852920 |
| Muscle contracture | 19.11 | 13.06 | 17 | 75353 | 2177 | 70850897 |
| Intention tremor | 19.03 | 13.06 | 11 | 75359 | 713 | 70852361 |
| Maternal exposure during pregnancy | 19.03 | 13.06 | 61 | 75309 | 115284 | 70737790 |
| Torticollis | 19.01 | 13.06 | 17 | 75353 | 2192 | 70850882 |
| Abdominal distension | 18.96 | 13.06 | 53 | 75317 | 104616 | 70748458 |
| Bacteraemia | 18.94 | 13.06 | 4 | 75366 | 29305 | 70823769 |
| Cerebral atrophy | 18.94 | 13.06 | 31 | 75339 | 7516 | 70845558 |
| Impaired quality of life | 18.92 | 13.06 | 34 | 75336 | 8882 | 70844192 |
| Myalgia | 18.86 | 13.06 | 103 | 75267 | 167789 | 70685285 |
| Dry skin | 18.78 | 13.06 | 19 | 75351 | 55912 | 70797162 |
| Hallucination, visual | 18.62 | 13.06 | 71 | 75299 | 29266 | 70823808 |
| Autonomic nervous system imbalance | 18.58 | 13.06 | 23 | 75347 | 4316 | 70848758 |
| Irritable bowel syndrome | 18.57 | 13.06 | 16 | 75354 | 50834 | 70802240 |
| Diabetic coma | 18.53 | 13.06 | 13 | 75357 | 1180 | 70851894 |
| Therapeutic product effect variable | 18.48 | 13.06 | 15 | 75355 | 1695 | 70851379 |
| Pulmonary arterial hypertension | 18.35 | 13.06 | 6 | 75364 | 32849 | 70820225 |
| Osteoporosis | 18.34 | 13.06 | 15 | 75355 | 48892 | 70804182 |
| Thyrotoxic crisis | 18.27 | 13.06 | 13 | 75357 | 1207 | 70851867 |
| Thyroiditis | 18.26 | 13.06 | 22 | 75348 | 4014 | 70849060 |
| Rectal haemorrhage | 18.23 | 13.06 | 26 | 75344 | 65805 | 70787269 |
| Product dose omission issue | 18.09 | 13.06 | 146 | 75224 | 217322 | 70635752 |
| Rhabdomyolysis | 18.02 | 13.06 | 168 | 75202 | 95592 | 70757482 |
| Oscillopsia | 17.99 | 13.06 | 7 | 75363 | 184 | 70852890 |
| Ill-defined disorder | 17.92 | 13.06 | 19 | 75351 | 54722 | 70798352 |
| Histrionic personality disorder | 17.88 | 13.06 | 5 | 75365 | 44 | 70853030 |
| Dysphagia | 17.87 | 13.06 | 191 | 75179 | 112643 | 70740431 |
| Femur fracture | 17.85 | 13.06 | 8 | 75362 | 36124 | 70816950 |
| Hyperkalaemia | 17.84 | 13.06 | 56 | 75314 | 106535 | 70746539 |
| Pulmonary oedema | 17.78 | 13.06 | 38 | 75332 | 82240 | 70770834 |
| Angioedema | 17.77 | 13.06 | 27 | 75343 | 66583 | 70786491 |
| Colitis ulcerative | 17.58 | 13.06 | 7 | 75363 | 33916 | 70819158 |
| Blood thyroid stimulating hormone increased | 17.57 | 13.06 | 32 | 75338 | 8447 | 70844627 |
| Unmasking of previously unidentified disease | 17.47 | 13.06 | 15 | 75355 | 1832 | 70851242 |
| Prescribed overdose | 17.44 | 13.06 | 66 | 75304 | 27115 | 70825959 |
| Megacolon | 17.31 | 13.06 | 19 | 75351 | 3137 | 70849937 |
| Urinary tract infection | 17.22 | 13.06 | 175 | 75195 | 248594 | 70604480 |
| Secondary tic | 17.18 | 13.06 | 4 | 75366 | 15 | 70853059 |
| Impaired work ability | 17.17 | 13.06 | 47 | 75323 | 16293 | 70836781 |
| Social anxiety disorder | 17.08 | 13.06 | 9 | 75361 | 486 | 70852588 |
| Irregular sleep wake rhythm disorder | 16.96 | 13.06 | 8 | 75362 | 340 | 70852734 |
| High-grade B-cell lymphoma | 16.91 | 13.06 | 7 | 75363 | 217 | 70852857 |
| Urine output increased | 16.89 | 13.06 | 15 | 75355 | 1916 | 70851158 |
| Osteonecrosis | 16.87 | 13.06 | 5 | 75365 | 29155 | 70823919 |
| Hepatic failure | 16.72 | 13.06 | 22 | 75348 | 57603 | 70795471 |
| Compulsions | 16.71 | 13.06 | 8 | 75362 | 352 | 70852722 |
| Bradycardia | 16.61 | 13.06 | 204 | 75166 | 124411 | 70728663 |
| Blood citric acid increased | 16.56 | 13.06 | 5 | 75365 | 59 | 70853015 |
| Hepatic cirrhosis | 16.50 | 13.06 | 6 | 75364 | 30725 | 70822349 |
| Blood pressure systolic increased | 16.47 | 13.06 | 22 | 75348 | 57237 | 70795837 |
| Merycism | 16.39 | 13.06 | 7 | 75363 | 235 | 70852839 |
| Mouth ulceration | 16.36 | 13.06 | 8 | 75362 | 34341 | 70818733 |
| Obesity | 16.35 | 13.06 | 64 | 75306 | 26707 | 70826367 |
| Dialysis | 16.28 | 13.06 | 48 | 75322 | 17354 | 70835720 |
| Dry eye | 16.18 | 13.06 | 7 | 75363 | 32275 | 70820799 |
| Pain in jaw | 16.11 | 13.06 | 13 | 75357 | 42656 | 70810418 |
| Device related infection | 16.10 | 13.06 | 7 | 75363 | 32178 | 70820896 |
| Hip fracture | 16.07 | 13.06 | 5 | 75365 | 28258 | 70824816 |
| Generalised tonic-clonic seizure | 16.06 | 13.06 | 87 | 75283 | 41574 | 70811500 |
| Fungal infection | 16.00 | 13.06 | 10 | 75360 | 37457 | 70815617 |
| Diabetic hyperosmolar coma | 15.98 | 13.06 | 10 | 75360 | 749 | 70852325 |
| Nephrolithiasis | 15.97 | 13.06 | 16 | 75354 | 47307 | 70805767 |
| Decreased interest | 15.97 | 13.06 | 19 | 75351 | 3422 | 70849652 |
| Pulmonary mass | 15.93 | 13.06 | 4 | 75366 | 26029 | 70827045 |
| Psychotic symptom | 15.72 | 13.06 | 16 | 75354 | 2422 | 70850652 |
| Hepatotoxicity | 15.72 | 13.06 | 90 | 75280 | 43896 | 70809178 |
| Clostridium difficile infection | 15.71 | 13.06 | 11 | 75359 | 38805 | 70814269 |
| Limbic encephalitis | 15.66 | 13.06 | 10 | 75360 | 776 | 70852298 |
| Staring | 15.62 | 13.06 | 16 | 75354 | 2440 | 70850634 |
| Injection site haemorrhage | 15.47 | 13.06 | 4 | 75366 | 25523 | 70827551 |
| Activation syndrome | 15.45 | 13.06 | 7 | 75363 | 271 | 70852803 |
| Eosinophilia | 15.41 | 13.06 | 84 | 75286 | 40235 | 70812839 |
| Blood triglycerides increased | 15.41 | 13.06 | 51 | 75319 | 19613 | 70833461 |
| Electrocardiogram T wave amplitude decreased | 15.38 | 13.06 | 9 | 75361 | 597 | 70852477 |
| Flatulence | 15.22 | 13.06 | 11 | 75359 | 38170 | 70814904 |
| International normalised ratio abnormal | 15.17 | 13.06 | 23 | 75347 | 5224 | 70847850 |
| Psychotic disorder due to a general medical condition | 15.17 | 13.06 | 7 | 75363 | 283 | 70852791 |
| Antidepressant drug level above therapeutic | 15.10 | 13.06 | 9 | 75361 | 618 | 70852456 |
| Hyperammonaemic encephalopathy | 15.07 | 13.06 | 21 | 75349 | 4422 | 70848652 |
| Acute myeloid leukaemia | 15.05 | 13.06 | 7 | 75363 | 30933 | 70822141 |
| Metabolic disorder | 14.99 | 13.06 | 29 | 75341 | 8011 | 70845063 |
| Therapy interrupted | 14.82 | 13.06 | 4 | 75366 | 24798 | 70828276 |
| Respiratory distress | 14.73 | 13.06 | 22 | 75348 | 54628 | 70798446 |
| Small intestinal obstruction | 14.68 | 13.06 | 4 | 75366 | 24651 | 70828423 |
| Potentiating drug interaction | 14.68 | 13.06 | 29 | 75341 | 8135 | 70844939 |
| Sciatica | 14.66 | 13.06 | 4 | 75366 | 24623 | 70828451 |
| Thyroid function test abnormal | 14.66 | 13.06 | 17 | 75353 | 2980 | 70850094 |
| Full blood count abnormal | 14.53 | 13.06 | 9 | 75361 | 33869 | 70819205 |
| Sleep apnoea syndrome | 14.48 | 13.06 | 71 | 75299 | 32642 | 70820432 |
| Incoherent | 14.42 | 13.06 | 27 | 75343 | 7279 | 70845795 |
| Basal cell carcinoma | 14.38 | 13.06 | 9 | 75361 | 33689 | 70819385 |
| Impaired self-care | 14.37 | 13.06 | 15 | 75355 | 2339 | 70850735 |
| Pneumocystis jirovecii pneumonia | 14.34 | 13.06 | 7 | 75363 | 30075 | 70822999 |
| Autoimmune thyroiditis | 14.30 | 13.06 | 19 | 75351 | 3823 | 70849251 |
| Breast cancer | 14.27 | 13.06 | 9 | 75361 | 33540 | 70819534 |
| Tic | 14.21 | 13.06 | 16 | 75354 | 2717 | 70850357 |
| Obstructive airways disorder | 14.18 | 13.06 | 5 | 75365 | 26108 | 70826966 |
| Coagulopathy | 14.03 | 13.06 | 9 | 75361 | 33240 | 70819834 |
| Fluid intake reduced | 14.03 | 13.06 | 23 | 75347 | 5584 | 70847490 |
| Body mass index increased | 14.00 | 13.06 | 13 | 75357 | 1759 | 70851315 |
| Cerebral infarction | 14.00 | 13.06 | 15 | 75355 | 42994 | 70810080 |
| Consciousness fluctuating | 13.98 | 13.06 | 13 | 75357 | 1763 | 70851311 |
| Refusal of treatment by patient | 13.93 | 13.06 | 29 | 75341 | 8441 | 70844633 |
| Cyclothymic disorder | 13.89 | 13.06 | 6 | 75364 | 207 | 70852867 |
| Polydipsia psychogenic | 13.84 | 13.06 | 6 | 75364 | 209 | 70852865 |
| Parasomnia | 13.81 | 13.06 | 8 | 75362 | 521 | 70852553 |
| Tension | 13.61 | 13.06 | 19 | 75351 | 4005 | 70849069 |
| Cardiac hypertrophy | 13.53 | 13.06 | 12 | 75358 | 1530 | 70851544 |
| Toxic cardiomyopathy | 13.53 | 13.06 | 7 | 75363 | 364 | 70852710 |
| Oral pain | 13.50 | 13.06 | 7 | 75363 | 29059 | 70824015 |
| Slow speech | 13.44 | 13.06 | 14 | 75356 | 2178 | 70850896 |
| Anaphylactic shock | 13.43 | 13.06 | 9 | 75361 | 32481 | 70820593 |
| Hypersexuality | 13.39 | 13.06 | 12 | 75358 | 1551 | 70851523 |
| Neoplasm malignant | 13.26 | 13.06 | 7 | 75363 | 28767 | 70824307 |
| Dyslipidaemia | 13.11 | 13.06 | 31 | 75339 | 9829 | 70843245 |
| Obsessive thoughts | 13.11 | 13.06 | 10 | 75360 | 1033 | 70852041 |
| Bone density decreased | 13.06 | 13.06 | 34 | 75336 | 11440 | 70841634 |
None
| Source | Code | Description |
|---|---|---|
| ATC | N05AN01 | NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Lithium |
| CHEBI has role | CHEBI:35477 | antimanic drugs |
| MeSH PA | D000928 | Antidepressive Agents |
| MeSH PA | D018692 | Antimanic Agents |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D011619 | Psychotropic Drugs |
| MeSH PA | D014149 | Tranquilizing Agents |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Bipolar disorder | indication | 13746004 | DOID:3312 |
| Pain | indication | 22253000 | |
| Rheumatoid arthritis | indication | 69896004 | DOID:7148 |
| Bipolar disorder in remission | indication | 85248005 | |
| Bipolar affective disorder, current episode manic | indication | 191618007 | |
| Headache disorder | indication | 230461009 | |
| Dysmenorrhea | indication | 266599000 | |
| Fever | indication | 386661006 | |
| Osteoarthritis | indication | 396275006 | |
| Juvenile rheumatoid arthritis | indication | 410795001 | |
| Vascular headache | off-label use | 128187005 | |
| Bipolar affective disorder, current episode depression | off-label use | 191627008 | DOID:3312 |
| Cluster Headache Prevention | off-label use | ||
| Rapid Cycling Bipolar Affective Disorder | off-label use | ||
| Psoriasis | contraindication | 9014002 | DOID:8893 |
| Diabetes insipidus | contraindication | 15771004 | DOID:9409 |
| Polyuria | contraindication | 28442001 | |
| Hypothyroidism | contraindication | 40930008 | DOID:1459 |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Chronic heart failure | contraindication | 48447003 | |
| Acute infectious disease | contraindication | 63171007 | |
| Hyponatremia | contraindication | 89627008 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Organic mental disorder | contraindication | 111479008 | |
| Plaque psoriasis | contraindication | 200965009 | |
| Pregnancy, function | contraindication | 289908002 | |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Severe dehydration | contraindication | 450316000 | |
| Lithium Toxicity | contraindication |
None
None
None
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glycogen synthase kinase-3 | Kinase | INHIBITOR | CHEMBL | CHEMBL | |||||
| Inositol-1(or 4)-monophosphatase 1 | Enzyme | INHIBITOR | CHEMBL | CHEMBL |
| ID | Source |
|---|---|
| 4018007 | VUID |
| N0000146351 | NUI |
| D00801 | KEGG_DRUG |
| 4018007 | VANDF |
| 4019803 | VANDF |
| C0085217 | UMLSCUI |
| CHEBI:6504 | CHEBI |
| CHEBI:30145 | CHEBI |
| CHEMBL1200826 | ChEMBL_ID |
| D016651 | MESH_DESCRIPTOR_UI |
| DB14509 | DRUGBANK_ID |
| 2BMD2GNA4V | UNII |
| 11125 | PUBCHEM_CID |
| 42351 | RXNORM |
| 1990 | MMSL |
| 4986 | MMSL |
| d00061 | MMSL |
| 001532 | NDDF |
| 001533 | NDDF |
| 16977003 | SNOMEDCT_US |
| 321719003 | SNOMEDCT_US |
| 387095003 | SNOMEDCT_US |
| 85899009 | SNOMEDCT_US |
| C0023870 | UMLSCUI |
| CHEMBL2146126 | ChEMBL_ID |
| 7439-93-2 | SECONDARY_CAS_RN |
| D008094 | MESH_DESCRIPTOR_UI |
| 3028194 | PUBCHEM_CID |
| 9FN79X2M3F | UNII |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Lithium Carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0020 | TABLET, EXTENDED RELEASE | 450 mg | ORAL | ANDA | 16 sections |
| Lithium Carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0020 | TABLET, EXTENDED RELEASE | 450 mg | ORAL | ANDA | 16 sections |
| Lithium Carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0021 | TABLET, EXTENDED RELEASE | 300 mg | ORAL | ANDA | 13 sections |
| Lithium Carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0021 | TABLET, EXTENDED RELEASE | 300 mg | ORAL | ANDA | 13 sections |
| Lithium Carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-2526 | CAPSULE, GELATIN COATED | 150 mg | ORAL | NDA | 26 sections |
| Lithium Carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-2526 | CAPSULE, GELATIN COATED | 150 mg | ORAL | NDA | 26 sections |
| Lithium Carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-2527 | CAPSULE, GELATIN COATED | 300 mg | ORAL | NDA | 26 sections |
| Lithium Carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-2527 | CAPSULE, GELATIN COATED | 300 mg | ORAL | NDA | 26 sections |
| Lithium Carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-2531 | CAPSULE, GELATIN COATED | 600 mg | ORAL | NDA | 26 sections |
| Lithium Carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-2531 | CAPSULE, GELATIN COATED | 600 mg | ORAL | NDA | 26 sections |
| Lithium Carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-4527 | TABLET | 300 mg | ORAL | NDA | 26 sections |
| Lithium Carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-4527 | TABLET | 300 mg | ORAL | NDA | 26 sections |
| Lithium Carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-8526 | CAPSULE, GELATIN COATED | 150 mg | ORAL | NDA | 26 sections |
| Lithium Carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-8526 | CAPSULE, GELATIN COATED | 150 mg | ORAL | NDA | 26 sections |
| Lithium Carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-8527 | CAPSULE, GELATIN COATED | 300 mg | ORAL | NDA | 26 sections |
| Lithium Carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-8527 | CAPSULE, GELATIN COATED | 300 mg | ORAL | NDA | 26 sections |
| Lithium Carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-8528 | TABLET | 300 mg | ORAL | NDA | 26 sections |
| Lithium Carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-8528 | TABLET | 300 mg | ORAL | NDA | 26 sections |
| Lithium Carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-8531 | CAPSULE, GELATIN COATED | 600 mg | ORAL | NDA | 26 sections |
| Lithium Carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-8531 | CAPSULE, GELATIN COATED | 600 mg | ORAL | NDA | 26 sections |
| Lithium Carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1300 | TABLET, FILM COATED, EXTENDED RELEASE | 300 mg | ORAL | ANDA | 17 sections |
| Lithium Carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1450 | TABLET, EXTENDED RELEASE | 450 mg | ORAL | ANDA | 15 sections |
| Lithium Carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1450 | TABLET, EXTENDED RELEASE | 450 mg | ORAL | ANDA | 15 sections |
| Lithium Carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8302 | CAPSULE | 300 mg | ORAL | ANDA | 26 sections |
| LITHIUM CARBONATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-781 | TABLET | 300 mg | ORAL | NDA | 2 sections |
| Lithium carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-763 | TABLET, FILM COATED, EXTENDED RELEASE | 300 mg | ORAL | ANDA | 15 sections |
| Lithium carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-763 | TABLET, FILM COATED, EXTENDED RELEASE | 300 mg | ORAL | ANDA | 15 sections |
| lithium carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 31722-544 | CAPSULE | 150 mg | ORAL | ANDA | 25 sections |
| lithium carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 31722-545 | CAPSULE | 300 mg | ORAL | ANDA | 25 sections |
| lithium carbonate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 31722-546 | CAPSULE | 600 mg | ORAL | ANDA | 25 sections |