lithium carbonate ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4207 554-13-2

Description:

MoleculeDescription

Synonyms:

  • lithium carbonate
  • carbonic acid, dilithium salt
  • dilithium carbonate
A lithium salt, classified as a mood-stabilizing agent. Lithium ion alters the metabolism of BIOGENIC MONOAMINES in the CENTRAL NERVOUS SYSTEM, and affects multiple neurotransmission systems.
  • Molecular weight: 73.89
  • Formula: CLi2O3
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 63.19
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
24 mmol O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 13 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 95 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 116.00 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
April 6, 1970 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 1370.85 12.54 1338 48314 211161 50344311
Tremor 740.83 12.54 725 48927 114178 50441294
Antipsychotic drug level increased 699.15 12.54 214 49438 2895 50552577
Neuroleptic malignant syndrome 649.78 12.54 283 49369 10847 50544625
Nephrogenic diabetes insipidus 629.70 12.54 151 49501 730 50554742
Drug interaction 548.20 12.54 816 48836 198805 50356667
Mania 501.99 12.54 235 49417 10681 50544791
Extrapyramidal disorder 443.30 12.54 221 49431 11549 50543923
Hypomania 334.60 12.54 136 49516 4369 50551103
Agitation 312.25 12.54 320 49332 53064 50502408
Psychotic disorder 302.83 12.54 215 49437 21597 50533875
Sopor 297.09 12.54 205 49447 19674 50535798
Drug abuse 292.25 12.54 326 49326 59520 50495952
Hyperparathyroidism 288.03 12.54 103 49549 2311 50553161
Antipsychotic drug level above therapeutic 272.00 12.54 79 49573 880 50554592
Sedation 268.66 12.54 230 49422 30380 50525092
Schizophrenia 264.13 12.54 134 49518 7263 50548209
Ataxia 263.98 12.54 166 49486 13620 50541852
Confusional state 261.05 12.54 568 49084 185360 50370112
Tardive dyskinesia 254.50 12.54 130 49522 7149 50548323
Completed suicide 252.65 12.54 459 49193 131430 50424042
Suicidal ideation 233.92 12.54 280 49372 55105 50500367
Intentional self-injury 232.59 12.54 188 49464 22924 50532548
Pain 217.39 12.54 152 49500 578751 49976721
Bipolar disorder 208.53 12.54 111 49541 6646 50548826
Suicide attempt 207.80 12.54 255 49397 51477 50503995
Parkinsonism 206.61 12.54 121 49531 8726 50546746
Dysarthria 200.35 12.54 214 49438 37189 50518283
Hypernatraemia 192.71 12.54 103 49549 6218 50549254
Akathisia 190.73 12.54 112 49540 8117 50547355
Serotonin syndrome 187.49 12.54 171 49481 24542 50530930
Muscle rigidity 184.78 12.54 117 49535 9712 50545760
Catatonia 182.80 12.54 84 49568 3652 50551820
Overdose 180.67 12.54 339 49313 99388 50456084
Salivary hypersecretion 172.23 12.54 97 49555 6494 50548978
Disorientation 164.09 12.54 188 49464 35296 50520176
Drug level increased 161.37 12.54 141 49511 19127 50536345
Somnolence 159.49 12.54 420 49232 154565 50400907
Aggression 158.00 12.54 145 49507 20971 50534501
Pleurothotonus 157.06 12.54 56 49596 1245 50554227
Arthralgia 156.86 12.54 121 49531 438581 50116891
Delusion 155.53 12.54 108 49544 10461 50545011
Dyspnoea 148.93 12.54 192 49460 547416 50008056
Diabetes insipidus 147.37 12.54 63 49589 2301 50553171
Rheumatoid arthritis 142.76 12.54 16 49636 202534 50352938
Delirium 140.16 12.54 180 49472 38012 50517460
Intentional overdose 139.64 12.54 233 49419 62271 50493201
Myoclonus 137.78 12.54 114 49538 14356 50541116
Altered state of consciousness 129.18 12.54 132 49520 21778 50533694
Disturbance in attention 128.87 12.54 156 49496 31030 50524442
Infusion related reaction 125.73 12.54 11 49641 169546 50385926
Hallucination, auditory 124.60 12.54 95 49557 10633 50544839
Electrocardiogram QT prolonged 120.70 12.54 197 49455 51689 50503783
Systemic lupus erythematosus 119.99 12.54 4 49648 140618 50414854
Polyuria 119.65 12.54 79 49573 7042 50548430
Jaundice cholestatic 116.96 12.54 69 49583 5042 50550430
Joint swelling 115.66 12.54 48 49604 245238 50310234
Swelling 110.90 12.54 30 49622 200842 50354630
Contraindicated product administered 106.88 12.54 11 49641 148947 50406525
Nasopharyngitis 106.15 12.54 29 49623 192898 50362574
Arthropathy 105.11 12.54 15 49637 157891 50397581
Restlessness 104.12 12.54 126 49526 25047 50530425
Hypersensitivity 101.58 12.54 42 49610 215119 50340353
Mental status changes 100.07 12.54 149 49503 36123 50519349
Hypothyroidism 99.67 12.54 144 49508 33981 50521491
Irritability 99.64 12.54 131 49521 28295 50527177
Abnormal behaviour 97.41 12.54 108 49544 19550 50535922
Glossodynia 96.14 12.54 4 49648 115565 50439907
Camptocormia 95.22 12.54 27 49625 274 50555198
Dyskinesia 93.97 12.54 126 49526 27735 50527737
Alopecia 93.37 12.54 63 49589 244984 50310488
Sinusitis 93.14 12.54 26 49626 170532 50384940
Fatigue 93.12 12.54 369 49283 707232 49848240
Polydipsia 92.68 12.54 50 49602 3074 50552398
Speech disorder 89.56 12.54 140 49512 35408 50520064
Weight increased 89.00 12.54 413 49239 201478 50353994
Granulocytopenia 87.80 12.54 58 49594 5173 50550299
Abdominal discomfort 87.65 12.54 60 49592 231581 50323891
Obsessive-compulsive disorder 86.84 12.54 49 49603 3291 50552181
Hyperreflexia 86.52 12.54 57 49595 5061 50550411
Postural tremor 84.50 12.54 23 49629 198 50555274
Depressed level of consciousness 83.48 12.54 168 49484 51785 50503687
Neurotoxicity 81.83 12.54 86 49566 14654 50540818
Depression 81.62 12.54 350 49302 165073 50390399
Bradyphrenia 81.57 12.54 59 49593 6093 50549379
Peripheral swelling 81.08 12.54 51 49601 205885 50349587
Hypercalcaemia 79.35 12.54 106 49546 23246 50532226
Coma 78.68 12.54 173 49479 56706 50498766
Drug intolerance 78.65 12.54 60 49592 219044 50336428
Pyramidal tract syndrome 78.27 12.54 24 49628 326 50555146
Poisoning 77.13 12.54 77 49575 12352 50543120
Encephalopathy 77.03 12.54 127 49525 33584 50521888
Mental disorder 76.53 12.54 101 49551 21890 50533582
Pruritus 75.20 12.54 101 49551 283467 50272005
Depressed mood 74.83 12.54 126 49526 33897 50521575
Dystonia 74.22 12.54 74 49578 11852 50543620
Anaemia 73.13 12.54 84 49568 252372 50303100
Body tinea 71.77 12.54 32 49620 1295 50554177
Stomatitis 71.36 12.54 8 49644 101336 50454136
Cough 69.10 12.54 81 49571 241183 50314289
Back pain 68.40 12.54 69 49583 219961 50335511
Mutism 67.40 12.54 31 49621 1350 50554122
Libido increased 67.31 12.54 30 49622 1213 50554259
Apathy 66.76 12.54 57 49595 7491 50547981
Rash 66.75 12.54 214 49438 437257 50118215
Treatment failure 66.33 12.54 26 49626 137611 50417861
Blood prolactin increased 66.13 12.54 40 49612 3059 50552413
Psychomotor hyperactivity 65.95 12.54 62 49590 9239 50546233
Antipsychotic drug level below therapeutic 65.14 12.54 20 49632 273 50555199
Aphasia 64.63 12.54 107 49545 28387 50527085
Inhibitory drug interaction 64.19 12.54 35 49617 2198 50553274
Pain in extremity 63.78 12.54 106 49546 272759 50282713
Death 63.35 12.54 141 49511 325238 50230234
Nephropathy 62.02 12.54 47 49605 5211 50550261
Grandiosity 61.31 12.54 19 49633 268 50555204
Parathyroid tumour benign 61.02 12.54 23 49629 601 50554871
Cogwheel rigidity 59.97 12.54 31 49621 1746 50553726
Drug reaction with eosinophilia and systemic symptoms 59.52 12.54 103 49549 28321 50527151
Electroencephalogram abnormal 59.22 12.54 39 49613 3460 50552012
Cerebellar syndrome 58.72 12.54 38 49614 3273 50552199
Psychiatric symptom 58.71 12.54 43 49609 4527 50550945
Stupor 58.38 12.54 39 49613 3544 50551928
Logorrhoea 57.47 12.54 33 49619 2291 50553181
Disease progression 57.42 12.54 12 49640 95854 50459618
Febrile neutropenia 56.93 12.54 13 49639 97654 50457818
Anticholinergic syndrome 56.83 12.54 30 49622 1765 50553707
Paranoia 56.77 12.54 60 49592 10288 50545184
Glucose tolerance impaired 56.54 12.54 44 49608 5074 50550398
Infection 56.33 12.54 52 49600 172902 50382570
Bipolar I disorder 55.64 12.54 28 49624 1490 50553982
Tachyphrenia 54.74 12.54 26 49626 1219 50554253
Galactorrhoea 54.66 12.54 38 49614 3685 50551787
Brugada syndrome 54.65 12.54 18 49634 312 50555160
Malignant neoplasm progression 54.57 12.54 3 49649 68121 50487351
Leukocytosis 52.84 12.54 86 49566 22493 50532979
Bradykinesia 52.70 12.54 38 49614 3905 50551567
Infection susceptibility increased 51.68 12.54 32 49620 2552 50552920
Treatment noncompliance 51.43 12.54 100 49552 30050 50525422
Headache 51.21 12.54 290 49362 506245 50049227
Schizoaffective disorder 51.04 12.54 30 49622 2176 50553296
Cognitive disorder 50.90 12.54 125 49527 43998 50511474
Electrocardiogram T wave abnormal 50.46 12.54 30 49622 2223 50553249
Acute kidney injury 50.15 12.54 389 49263 227669 50327803
Personality disorder 49.57 12.54 38 49614 4286 50551186
Euphoric mood 49.50 12.54 37 49615 4018 50551454
Enuresis 49.39 12.54 29 49623 2100 50553372
Atrial fibrillation 49.37 12.54 19 49633 101726 50453746
Behaviour disorder 48.94 12.54 30 49622 2350 50553122
Hostility 48.66 12.54 27 49625 1755 50553717
Psychiatric decompensation 48.46 12.54 24 49628 1234 50554238
White blood cell count increased 48.02 12.54 119 49533 42121 50513351
Gestational diabetes 47.71 12.54 47 49605 7418 50548054
Resting tremor 47.42 12.54 20 49632 706 50554766
Chronic kidney disease 47.30 12.54 114 49538 39657 50515815
Poisoning deliberate 47.23 12.54 48 49604 7864 50547608
Blood creatine phosphokinase increased 46.87 12.54 89 49563 26278 50529194
Therapeutic product effect decreased 46.59 12.54 39 49613 136011 50419461
Anxiety 46.54 12.54 316 49336 177290 50378182
Mental impairment 46.11 12.54 58 49594 11986 50543486
Gastrointestinal haemorrhage 44.27 12.54 9 49643 73312 50482160
Action tremor 44.16 12.54 15 49637 287 50555185
Drooling 43.83 12.54 32 49620 3352 50552120
Gastrointestinal disorder 43.62 12.54 19 49633 94437 50461035
Impaired healing 43.33 12.54 8 49644 69778 50485694
Neutrophil count increased 43.05 12.54 61 49591 14134 50541338
Substance abuse 42.43 12.54 34 49618 4090 50551382
Cardiac failure congestive 42.22 12.54 15 49637 84367 50471105
Renal cyst 41.78 12.54 47 49605 8640 50546832
Urticaria 40.95 12.54 40 49612 129521 50425951
Bundle branch block right 40.92 12.54 35 49617 4610 50550862
Sleep-related eating disorder 39.88 12.54 18 49634 750 50554722
Psychomotor skills impaired 39.86 12.54 25 49627 2039 50553433
Oculogyric crisis 39.86 12.54 22 49630 1415 50554057
Anger 39.35 12.54 52 49600 11281 50544191
Soft tissue injury 39.20 12.54 22 49630 1462 50554010
Arthritis 39.17 12.54 18 49634 86703 50468769
Cardio-respiratory arrest 38.98 12.54 129 49523 53763 50501709
Persecutory delusion 38.93 12.54 26 49626 2361 50553111
Parkinsonian gait 38.59 12.54 15 49637 427 50555045
Blister 38.17 12.54 18 49634 85400 50470072
Injection site erythema 38.04 12.54 13 49639 74923 50480549
Bronchitis 38.00 12.54 28 49624 104131 50451341
Asterixis 37.97 12.54 20 49632 1171 50554301
Hepatotoxicity 37.84 12.54 83 49569 27143 50528329
Hallucination 37.68 12.54 116 49536 46541 50508931
Diarrhoea 37.56 12.54 383 49269 588093 49967379
Hyperprolactinaemia 37.32 12.54 29 49623 3336 50552136
Discomfort 37.18 12.54 31 49621 108349 50447123
Hypertonia 37.18 12.54 31 49621 3942 50551530
Hypothermia 36.98 12.54 52 49600 11964 50543508
Impaired quality of life 36.62 12.54 37 49615 6019 50549453
Cholelithiasis 36.03 12.54 100 49552 37873 50517599
Poor quality sleep 35.73 12.54 61 49591 16585 50538887
Chest pain 35.73 12.54 75 49577 176807 50378665
Interstitial lung disease 35.47 12.54 5 49647 53171 50502301
Urinary retention 35.45 12.54 79 49573 26111 50529361
Choreoathetosis 35.11 12.54 14 49638 427 50555045
Goitre 34.94 12.54 34 49618 5286 50550186
Urinary incontinence 34.77 12.54 82 49570 28126 50527346
Protein C increased 34.62 12.54 10 49642 109 50555363
Lethargy 34.58 12.54 117 49535 49315 50506157
Withdrawal syndrome 34.57 12.54 62 49590 17528 50537944
Visuospatial deficit 34.16 12.54 7 49645 13 50555459
Pneumonia 33.80 12.54 225 49427 378176 50177296
Electrocardiogram T wave inversion 33.79 12.54 27 49625 3234 50552238
Miosis 33.57 12.54 36 49616 6274 50549198
Abdominal pain upper 33.49 12.54 66 49586 159243 50396229
Thinking abnormal 33.37 12.54 44 49608 9523 50545949
Intentional product use issue 33.17 12.54 17 49635 76901 50478571
Neuropathy peripheral 32.79 12.54 28 49624 96729 50458743
Product use issue 32.22 12.54 61 49591 149414 50406058
Hallucination, visual 32.01 12.54 58 49594 16524 50538948
Blood sodium increased 31.76 12.54 23 49629 2379 50553093
Lower respiratory tract infection 31.72 12.54 28 49624 95173 50460299
Post-traumatic neck syndrome 31.62 12.54 21 49631 1889 50553583
Myocarditis 31.59 12.54 39 49613 7908 50547564
Haemodialysis 31.58 12.54 40 49612 8322 50547150
Impulsive behaviour 31.58 12.54 19 49633 1439 50554033
Gait disturbance 31.35 12.54 253 49399 149752 50405720
Renal oncocytoma 30.88 12.54 7 49645 25 50555447
Impaired self-care 30.81 12.54 20 49632 1731 50553741
Sternal fracture 30.73 12.54 21 49631 1981 50553491
Schizoaffective disorder bipolar type 30.45 12.54 9 49643 107 50555365
Drug hypersensitivity 30.25 12.54 135 49517 250875 50304597
Injection site swelling 30.16 12.54 3 49649 41770 50513702
Blood bilirubin increased 30.03 12.54 84 49568 31954 50523518
Hereditary ataxia 29.68 12.54 7 49645 31 50555441
Cerebellar atrophy 29.54 12.54 14 49638 653 50554819
Drug level above therapeutic 29.47 12.54 27 49625 3893 50551579
Hyperthyroidism 29.34 12.54 47 49605 12128 50543344
Abdominal pain 29.10 12.54 126 49526 236102 50319370
International normalised ratio increased 28.92 12.54 4 49648 43148 50512324
Sepsis 28.86 12.54 54 49598 132871 50422601
Drug withdrawal syndrome 28.86 12.54 71 49581 25010 50530462
Pressure of speech 28.81 12.54 13 49639 541 50554931
Hyperlipidaemia 28.60 12.54 57 49595 17433 50538039
Platelet count decreased 28.59 12.54 34 49618 100692 50454780
Mood swings 28.54 12.54 54 49598 15900 50539572
Hallucinations, mixed 28.42 12.54 27 49625 4076 50551396
Papillary thyroid cancer 28.26 12.54 20 49632 1995 50553477
Clonus 28.02 12.54 27 49625 4148 50551324
Depressive symptom 27.96 12.54 24 49628 3176 50552296
Induced abortion failed 27.93 12.54 10 49642 225 50555247
Injection site pain 27.92 12.54 41 49611 110983 50444489
Cerebrovascular accident 27.91 12.54 31 49621 94649 50460823
Insomnia 27.86 12.54 278 49374 174587 50380885
Rhabdomyolysis 27.85 12.54 93 49559 38934 50516538
Thrombocytopenia 27.60 12.54 52 49600 127621 50427851
Respiratory arrest 27.46 12.54 78 49574 29931 50525541
Mobility decreased 27.26 12.54 23 49629 79925 50475547
Osteoarthritis 26.95 12.54 17 49635 68589 50486883
Musculoskeletal pain 26.85 12.54 19 49633 72158 50483314
Adams-Stokes syndrome 26.74 12.54 7 49645 51 50555421
Nausea 26.73 12.54 510 49142 704888 49850584
Sinus bradycardia 26.59 12.54 47 49605 13136 50542336
Electrocardiogram abnormal 26.56 12.54 35 49617 7570 50547902
Deprescribing error 26.56 12.54 6 49646 21 50555451
Social avoidant behaviour 26.54 12.54 22 49630 2775 50552697
Acute psychosis 26.53 12.54 20 49632 2200 50553272
Affect lability 26.30 12.54 38 49614 8960 50546512
Muscle twitching 26.09 12.54 51 49601 15380 50540092
Differential white blood cell count abnormal 25.93 12.54 13 49639 686 50554786
Pleural effusion 25.90 12.54 25 49627 81429 50474043
Reflexes abnormal 25.83 12.54 12 49640 535 50554937
Persistent depressive disorder 25.71 12.54 14 49638 877 50554595
Asthma 25.52 12.54 30 49622 89307 50466165
Hyperthermia malignant 25.25 12.54 13 49639 726 50554746
Nodal rhythm 25.20 12.54 17 49635 1570 50553902
Maternal exposure during pregnancy 25.09 12.54 77 49575 159701 50395771
Thyrotoxic crisis 25.04 12.54 13 49639 739 50554733
Ileus paralytic 24.96 12.54 25 49627 4025 50551447
Muscle contractions involuntary 24.50 12.54 18 49634 1904 50553568
Eye movement disorder 24.30 12.54 26 49626 4519 50550953
Paraesthesia 24.25 12.54 51 49601 120192 50435280
Hypokinesia 23.92 12.54 43 49609 12174 50543298
Antidepressant drug level increased 23.29 12.54 9 49643 252 50555220
Nystagmus 23.25 12.54 28 49624 5533 50549939
Sluggishness 23.17 12.54 25 49627 4388 50551084
Feeling guilty 23.09 12.54 11 49641 519 50554953
Major depression 23.00 12.54 31 49621 6853 50548619
Bruxism 22.97 12.54 21 49631 3019 50552453
Conversion disorder 22.75 12.54 16 49636 1580 50553892
Mood altered 22.56 12.54 43 49609 12730 50542742
Knee arthroplasty 22.49 12.54 4 49648 35842 50519630
Fibromyalgia 22.48 12.54 8 49644 44970 50510502
Ideas of reference 22.31 12.54 7 49645 103 50555369
Cerebral atrophy 22.31 12.54 25 49627 4576 50550896
Ammonia increased 22.22 12.54 24 49628 4217 50551255
International normalised ratio abnormal 22.19 12.54 20 49632 2823 50552649
Purpura 22.17 12.54 37 49615 9874 50545598
Mucosal inflammation 22.11 12.54 6 49646 40136 50515336
Encopresis 21.83 12.54 7 49645 111 50555361
Coordination abnormal 21.83 12.54 40 49612 11494 50543978
Histrionic personality disorder 21.80 12.54 6 49646 54 50555418
Anaphylactic reaction 21.78 12.54 13 49639 54042 50501430
Poverty of speech 21.49 12.54 9 49643 312 50555160
Compulsive sexual behaviour 21.42 12.54 6 49646 58 50555414
Electroconvulsive therapy 21.15 12.54 6 49646 61 50555411
Language disorder 21.12 12.54 16 49636 1772 50553700
Bone pain 21.02 12.54 10 49642 47219 50508253
Psoriatic arthropathy 20.87 12.54 10 49642 47022 50508450
Blunted affect 20.84 12.54 8 49644 220 50555252
Oscillopsia 20.70 12.54 7 49645 132 50555340
Lung disorder 20.69 12.54 9 49643 44790 50510682
Limbic encephalitis 20.67 12.54 8 49644 225 50555247
Hypotonia 20.43 12.54 32 49620 8102 50547370
Borderline personality disorder 20.38 12.54 11 49641 677 50554795
Myocarditis septic 19.94 12.54 5 49647 30 50555442
Status epilepticus 19.92 12.54 42 49610 13364 50542108
Increased appetite 19.77 12.54 32 49620 8329 50547143
Influenza 19.76 12.54 36 49616 89502 50465970
Drug level decreased 19.70 12.54 28 49624 6505 50548967
Megacolon 19.57 12.54 15 49637 1691 50553781
Long QT syndrome 19.56 12.54 19 49633 2948 50552524
Water intoxication 19.46 12.54 9 49643 397 50555075
Productive cough 19.43 12.54 14 49638 52680 50502792
Nephropathy toxic 19.35 12.54 31 49621 7998 50547474
Hyporeflexia 19.31 12.54 15 49637 1725 50553747
Neuropsychiatric symptoms 19.25 12.54 10 49642 569 50554903
Lactate pyruvate ratio increased 19.02 12.54 6 49646 90 50555382
Irregular sleep wake rhythm disorder 18.97 12.54 7 49645 172 50555300
Disinhibition 18.70 12.54 11 49641 799 50554673
Haemorrhage 18.68 12.54 15 49637 53426 50502046
Rhinorrhoea 18.63 12.54 14 49638 51569 50503903
Ascites 18.58 12.54 6 49646 35855 50519617
Merycism 18.53 12.54 7 49645 184 50555288
Delusion of reference 18.49 12.54 6 49646 99 50555373
Hyperammonaemia 18.48 12.54 23 49629 4701 50550771
Lipids decreased 18.44 12.54 4 49648 11 50555461
Flat affect 18.41 12.54 13 49639 1292 50554180
Dyspnoea exertional 18.39 12.54 14 49638 51219 50504253
Memory impairment 18.31 12.54 137 49515 79223 50476249
Cardiac failure 18.23 12.54 29 49623 76011 50479461
Skin ulcer 18.14 12.54 6 49646 35312 50520160
Arachnoid cyst 18.12 12.54 7 49645 196 50555276
Self-injurious ideation 18.03 12.54 16 49636 2213 50553259
Somatic symptom disorder 17.84 12.54 15 49637 1929 50553543
Mydriasis 17.82 12.54 35 49617 10592 50544880
Acquired cystic kidney disease 17.79 12.54 5 49647 49 50555423
Antipsychotic drug level decreased 17.76 12.54 7 49645 207 50555265
Essential tremor 17.73 12.54 11 49641 880 50554592
Throat irritation 17.66 12.54 4 49648 30235 50525237
Hyperthermia 17.58 12.54 29 49623 7667 50547805
Haemoglobin decreased 17.45 12.54 65 49587 127151 50428321
Homicidal ideation 17.44 12.54 14 49638 1688 50553784
Urine osmolarity increased 17.42 12.54 6 49646 120 50555352
Hallucination, olfactory 17.33 12.54 7 49645 221 50555251
Psychomotor retardation 17.31 12.54 19 49633 3399 50552073
Pain in jaw 17.31 12.54 8 49644 38420 50517052
Refusal of treatment by patient 17.26 12.54 23 49629 5030 50550442
Psychotic disorder due to a general medical condition 17.15 12.54 7 49645 227 50555245
Negativism 17.11 12.54 8 49644 362 50555110
Pneumonitis 17.04 12.54 4 49648 29506 50525966
Clear cell renal cell carcinoma 17.01 12.54 12 49640 1191 50554281
Staring 17.00 12.54 13 49639 1461 50554011
Blood citric acid increased 16.95 12.54 5 49647 59 50555413
Dialysis 16.95 12.54 32 49620 9406 50546066
Balance disorder 16.93 12.54 123 49529 70467 50485005
Drug ineffective 16.89 12.54 646 49006 818687 49736785
Antidepressant drug level above therapeutic 16.84 12.54 8 49644 375 50555097
Affective disorder 16.81 12.54 23 49629 5158 50550314
Dysphoria 16.72 12.54 22 49630 4752 50550720
Plasma cell myeloma 16.66 12.54 5 49647 31317 50524155
Decreased appetite 16.65 12.54 122 49530 200801 50354671
Thyroiditis 16.60 12.54 14 49638 1808 50553664
Alcohol interaction 16.57 12.54 15 49637 2129 50553343
Tachycardia 16.55 12.54 160 49492 99603 50455869
Slow speech 16.33 12.54 12 49640 1270 50554202
Injection site reaction 16.32 12.54 15 49637 50017 50505455
General physical health deterioration 16.30 12.54 78 49574 142356 50413116
Agranulocytosis 16.13 12.54 52 49600 21369 50534103
Irritable bowel syndrome 16.10 12.54 16 49636 51425 50504047
Ear infection 16.07 12.54 3 49649 25967 50529505
Epileptic encephalopathy 16.04 12.54 7 49645 269 50555203
Unresponsive to stimuli 16.01 12.54 66 49586 30543 50524929
Ill-defined disorder 15.99 12.54 18 49634 54636 50500836
Upper respiratory tract infection 15.92 12.54 25 49627 65873 50489599
Osteonecrosis of jaw 15.89 12.54 6 49646 32520 50522952
Neurological symptom 15.87 12.54 21 49631 4561 50550911
Acalculia 15.71 12.54 3 49649 3 50555469
Toxic encephalopathy 15.70 12.54 23 49629 5492 50549980
Retroperitoneal fibrosis 15.64 12.54 7 49645 286 50555186
Potentiating drug interaction 15.61 12.54 19 49633 3797 50551675
Compartment syndrome 15.58 12.54 14 49638 1968 50553504
Tonsillar hypertrophy 15.51 12.54 10 49642 856 50554616
Neonatal respiratory distress 15.48 12.54 7 49645 293 50555179
Slow response to stimuli 15.47 12.54 10 49642 859 50554613
Renal impairment 15.46 12.54 127 49525 75534 50479938
Muscle spasms 15.42 12.54 67 49585 125486 50429986
Echolalia 15.23 12.54 6 49646 177 50555295
Medication error 15.22 12.54 73 49579 36031 50519441
Femur fracture 15.10 12.54 9 49643 37455 50518017
Malaise 15.08 12.54 235 49417 335297 50220175
Urine output increased 15.06 12.54 11 49641 1153 50554319
Impaired work ability 15.05 12.54 38 49614 13602 50541870
Cystitis 14.97 12.54 13 49639 44551 50510921
Blood urea increased 14.91 12.54 54 49598 23531 50531941
Melaena 14.82 12.54 4 49648 26860 50528612
Epistaxis 14.76 12.54 25 49627 63929 50491543
Breast engorgement 14.75 12.54 5 49647 95 50555377
Foetal malnutrition 14.71 12.54 5 49647 96 50555376
Cardiomyopathy acute 14.69 12.54 6 49646 195 50555277
Thrombosis 14.64 12.54 20 49632 55813 50499659
Injection site bruising 14.59 12.54 9 49643 36759 50518713
Thought blocking 14.56 12.54 5 49647 99 50555373
Urinary tract infection 14.54 12.54 145 49507 223875 50331597
Bone density decreased 14.53 12.54 33 49619 11042 50544430
Tooth injury 14.46 12.54 10 49642 961 50554511
Movement disorder 14.38 12.54 44 49608 17588 50537884
Haematoma 14.30 12.54 6 49646 30504 50524968
Hypotonia neonatal 14.23 12.54 10 49642 987 50554485
Distal intestinal obstruction syndrome 14.17 12.54 7 49645 358 50555114
Hyperhidrosis 14.13 12.54 142 49510 89284 50466188
Hip fracture 14.05 12.54 4 49648 25927 50529545
Delusional perception 14.04 12.54 6 49646 219 50555253
Osteoporosis 14 12.54 14 49638 44865 50510607
Myocardial infarction 13.90 12.54 43 49609 88984 50466488
Blood pressure fluctuation 13.89 12.54 9 49643 35814 50519658
Stereotypy 13.87 12.54 7 49645 375 50555097
Decreased activity 13.86 12.54 21 49631 5166 50550306
Breast cancer 13.82 12.54 13 49639 42877 50512595
Cardiac arrest 13.79 12.54 134 49518 83517 50471955
Dysphemia 13.78 12.54 14 49638 2292 50553180
Gaze palsy 13.73 12.54 11 49641 1322 50554150
Ileus 13.71 12.54 36 49616 13193 50542279
Localised infection 13.68 12.54 4 49648 25481 50529991
Thought insertion 13.63 12.54 3 49649 9 50555463
Glomerulonephritis minimal lesion 13.62 12.54 6 49646 236 50555236
Middle insomnia 13.51 12.54 30 49622 9891 50545581
Progressive supranuclear palsy 13.50 12.54 4 49648 48 50555424
Distractibility 13.45 12.54 7 49645 400 50555072
Muscle tone disorder 13.43 12.54 5 49647 126 50555346
Polyhydramnios 13.41 12.54 13 49639 2012 50553460
Suspected suicide 13.35 12.54 21 49631 5336 50550136
Amimia 13.28 12.54 4 49648 51 50555421
Abulia 13.13 12.54 7 49645 420 50555052
Amenorrhoea 13.10 12.54 27 49625 8457 50547015
Cerebellar ataxia 12.98 12.54 9 49643 869 50554603
COVID-19 12.97 12.54 16 49636 46646 50508826
Blood pressure increased 12.96 12.54 77 49575 133055 50422417
Haematochezia 12.95 12.54 12 49640 39870 50515602
Dry skin 12.88 12.54 14 49638 43177 50512295
Brain injury 12.86 12.54 22 49630 5992 50549480
Colectomy total 12.78 12.54 5 49647 145 50555327
Concussion 12.64 12.54 25 49627 7603 50547869
Presyncope 12.62 12.54 4 49648 24194 50531278
Divorced 12.59 12.54 3 49649 14 50555458
Hyperleukocytosis 12.59 12.54 7 49645 457 50555015

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 818.70 14.12 1057 36978 172604 29363888
Neuroleptic malignant syndrome 582.62 14.12 322 37713 15826 29520666
Antipsychotic drug level increased 532.59 14.12 188 37847 3055 29533437
Tremor 490.97 14.12 536 37499 73002 29463490
Mania 475.05 14.12 229 37806 8434 29528058
Nephrogenic diabetes insipidus 397.15 14.12 117 37918 1022 29535470
Akathisia 300.89 14.12 155 37880 6587 29529905
Suicide attempt 283.61 14.12 280 37755 33830 29502662
Extrapyramidal disorder 269.56 14.12 170 37865 10661 29525831
Obsessive-compulsive disorder 247.87 14.12 120 37915 4456 29532036
Parkinsonism 245.61 14.12 139 37896 7139 29529353
Antipsychotic drug level below therapeutic 230.21 14.12 89 37946 1885 29534607
Drug interaction 219.94 14.12 653 37382 196732 29339760
Serotonin syndrome 196.43 14.12 170 37865 17342 29519150
Psychotic disorder 189.69 14.12 178 37857 20176 29516316
Antipsychotic drug level above therapeutic 185.20 14.12 65 37970 1036 29535456
Dysarthria 156.78 14.12 196 37839 30715 29505777
Suicidal ideation 153.98 14.12 206 37829 34510 29501982
Agitation 153.48 14.12 253 37782 51051 29485441
Disinhibition 152.23 14.12 72 37963 2535 29533957
Euphoric mood 151.66 14.12 88 37947 4737 29531755
Psychomotor hyperactivity 151.45 14.12 107 37928 8106 29528386
Granulocytopenia 148.90 14.12 94 37941 5900 29530592
Sedation 148.50 14.12 145 37890 17260 29519232
Hypomania 145.48 14.12 66 37969 2109 29534383
Therapeutic product effect variable 144.96 14.12 63 37972 1814 29534678
Diabetes insipidus 144.52 14.12 68 37967 2366 29534126
Weight increased 142.00 14.12 308 37727 76359 29460133
Increased appetite 140.47 14.12 91 37944 5973 29530519
Confusional state 129.79 14.12 410 37625 127467 29409025
Schizophrenia 129.15 14.12 89 37946 6476 29530016
Dyspnoea 124.08 14.12 143 37892 326589 29209903
Aggression 123.84 14.12 188 37847 35353 29501139
Ataxia 122.74 14.12 111 37924 11992 29524500
Irritability 117.99 14.12 144 37891 22008 29514484
Febrile neutropenia 113.45 14.12 8 38027 112232 29424260
Salivary hypersecretion 112.81 14.12 86 37949 7323 29529169
Dyskinesia 106.17 14.12 130 37905 19931 29516561
Bipolar disorder 103.30 14.12 60 37975 3235 29533257
Delusion 102.38 14.12 97 37938 11119 29525373
Death 98.19 14.12 182 37853 341902 29194590
Hallucination, auditory 97.31 14.12 88 37947 9505 29526987
Tardive dyskinesia 93.46 14.12 67 37968 5191 29531301
Completed suicide 92.95 14.12 291 37744 89955 29446537
Myoclonus 91.96 14.12 99 37936 13210 29523282
Muscle rigidity 88.98 14.12 83 37952 9328 29527164
Hypernatraemia 87.47 14.12 74 37961 7312 29529180
Arthralgia 85.98 14.12 36 37999 139581 29396911
Leukopenia 84.68 14.12 206 37829 54997 29481495
Bruxism 84.07 14.12 41 37994 1546 29534946
Priapism 81.64 14.12 58 37977 4430 29532062
Anaemia 81.57 14.12 83 37952 200868 29335624
Hyperparathyroidism 80.81 14.12 36 37999 1101 29535391
Schizoaffective disorder 78.97 14.12 35 38000 1057 29535435
Overdose 78.17 14.12 253 37782 79566 29456926
Cough 75.91 14.12 34 38001 126693 29409799
White blood cell count increased 75.47 14.12 156 37879 37360 29499132
Somnolence 73.96 14.12 277 37758 93678 29442814
Oppositional defiant disorder 72.98 14.12 27 38008 504 29535988
Delirium 71.38 14.12 157 37878 39240 29497252
Catatonia 70.53 14.12 53 37982 4415 29532077
Coordination abnormal 69.68 14.12 64 37971 7050 29529442
Intentional overdose 68.07 14.12 152 37883 38376 29498116
Decreased eye contact 67.90 14.12 25 38010 460 29536032
Pneumonia 67.21 14.12 201 37834 319971 29216521
Pain 67.07 14.12 73 37962 171359 29365133
Pain in extremity 65.55 14.12 30 38005 110403 29426089
Disease progression 65.26 14.12 13 38022 81903 29454589
Abnormal behaviour 65.01 14.12 111 37924 23016 29513476
Malignant neoplasm progression 64.88 14.12 9 38026 73850 29462642
Sopor 64.66 14.12 75 37960 10859 29525633
Homicidal ideation 63.72 14.12 40 37995 2484 29534008
Mental status changes 61.92 14.12 138 37897 34789 29501703
Coma 59.17 14.12 146 37889 39304 29497188
Obesity 58.91 14.12 68 37967 9795 29526697
Cognitive disorder 58.58 14.12 107 37928 23392 29513100
Dyslipidaemia 58.34 14.12 54 37981 6007 29530485
Hyperreflexia 57.89 14.12 39 37996 2733 29533759
Neutrophil count increased 57.09 14.12 82 37953 14660 29521832
Polydipsia 56.70 14.12 42 37993 3423 29533069
Blood creatine phosphokinase increased 56.35 14.12 146 37889 40498 29495994
Restlessness 54.14 14.12 100 37935 22045 29514447
Dystonia 52.90 14.12 64 37971 9685 29526807
Depressed level of consciousness 52.55 14.12 134 37901 36808 29499684
Delusion of grandeur 52.46 14.12 20 38015 407 29536085
Brugada syndrome 52.41 14.12 23 38012 678 29535814
Prescribed overdose 52.08 14.12 60 37975 8623 29527869
Pancytopenia 51.87 14.12 21 38014 83147 29453345
Disturbance in attention 51.45 14.12 96 37939 21328 29515164
Hypothyroidism 50.97 14.12 81 37954 15825 29520667
Atrial fibrillation 50.87 14.12 37 37998 105609 29430883
Interstitial lung disease 50.76 14.12 7 38028 57711 29478781
Affect lability 50.71 14.12 39 37996 3363 29533129
Neurotoxicity 50.43 14.12 77 37958 14536 29521956
Treatment noncompliance 50.19 14.12 102 37933 24125 29512367
Disorientation 49.40 14.12 114 37921 29401 29507091
Thinking abnormal 49.14 14.12 46 37989 5190 29531302
Back pain 49.02 14.12 36 37999 102248 29434244
Speech disorder 47.52 14.12 98 37937 23418 29513074
Anxiety 47.14 14.12 226 37809 85139 29451353
Myocarditis 46.98 14.12 64 37971 10892 29525600
Fatigue 46.93 14.12 229 37806 316592 29219900
Pruritus 46.50 14.12 49 37986 116800 29419692
Dystonic tremor 46.47 14.12 15 38020 182 29536310
Thrombocytopenia 45.76 14.12 64 37971 134759 29401733
Oedema peripheral 45.18 14.12 40 37995 103517 29432975
Peripheral swelling 45.10 14.12 13 38022 63726 29472766
Electrocardiogram QRS complex prolonged 44.24 14.12 39 37996 4071 29532421
Cardiac failure congestive 43.59 14.12 22 38013 76559 29459933
Gastrointestinal haemorrhage 42.14 14.12 25 38010 79508 29456984
Myocardial infarction 41.95 14.12 48 37987 110248 29426244
Clonus 41.57 14.12 30 38005 2348 29534144
Paranoia 41.30 14.12 57 37978 9820 29526672
Cerebellar syndrome 41.25 14.12 28 38007 1986 29534506
Failure to suspend medication 39.83 14.12 16 38019 376 29536116
Sepsis 39.78 14.12 77 37958 142605 29393887
Intentional self-injury 39.30 14.12 63 37972 12398 29524094
Rash 39.10 14.12 120 37915 189699 29346793
General physical health deterioration 38.86 14.12 45 37990 102812 29433680
Choreoathetosis 38.55 14.12 21 38014 999 29535493
Logorrhoea 38.03 14.12 28 38007 2260 29534232
Hyperparathyroidism primary 37.76 14.12 12 38023 138 29536354
Infusion related reaction 37.03 14.12 6 38029 43880 29492612
Blood thyroid stimulating hormone decreased 36.83 14.12 25 38010 1773 29534719
Insomnia 36.68 14.12 217 37818 88544 29447948
Electrocardiogram QT prolonged 36.64 14.12 116 37919 36021 29500471
Depression 36.38 14.12 210 37825 84937 29451555
Drug level above therapeutic 34.82 14.12 31 38004 3279 29533213
Nephropathy 34.34 14.12 38 37997 5225 29531267
Affective disorder 34.33 14.12 30 38005 3096 29533396
Apathy 34.28 14.12 41 37994 6130 29530362
Hyperprolactinaemia 34.27 14.12 21 38014 1249 29535243
Tachycardia 33.86 14.12 183 37852 72227 29464265
Leukocytosis 33.56 14.12 80 37955 21062 29515430
Antipsychotic drug level decreased 33.15 14.12 18 38017 851 29535641
Distractibility 33.03 14.12 13 38022 289 29536203
Drug level increased 33.02 14.12 74 37961 18713 29517779
Balance disorder 32.99 14.12 112 37923 36058 29500434
Septic shock 32.67 14.12 20 38015 62540 29473952
Grandiosity 32.22 14.12 13 38022 309 29536183
Hyperkinesia 32.20 14.12 22 38013 1577 29534915
Diarrhoea 32.07 14.12 274 37761 332424 29204068
Joint swelling 31.81 14.12 12 38023 49618 29486874
Polyuria 31.55 14.12 43 37992 7319 29529173
Mental impairment 31.30 14.12 48 37987 9093 29527399
Enuresis 31.30 14.12 24 38011 2060 29534432
Pressure of speech 30.95 14.12 14 38021 444 29536048
Trismus 30.64 14.12 25 38010 2348 29534144
Rheumatoid arthritis 30.50 14.12 3 38032 32149 29504343
Poisoning deliberate 30.08 14.12 37 37998 5694 29530798
Bipolar I disorder 30.01 14.12 16 38019 729 29535763
Patient restraint 29.82 14.12 9 38026 86 29536406
Coronary artery disease 29.49 14.12 10 38025 44180 29492312
Abulia 29.48 14.12 14 38021 497 29535995
Sexually inappropriate behaviour 29.44 14.12 13 38022 389 29536103
Melaena 29.34 14.12 3 38032 31173 29505319
Epistaxis 29.19 14.12 15 38020 51689 29484803
Metabolic syndrome 29.04 14.12 20 38015 1453 29535039
Anger 28.94 14.12 51 37984 10839 29525653
Ascites 28.76 14.12 6 38029 36613 29499879
Mental disorder 28.72 14.12 56 37979 12849 29523643
Psychiatric decompensation 28.66 14.12 20 38015 1484 29535008
Decreased appetite 28.42 14.12 94 37941 145248 29391244
Thrombosis 28.27 14.12 10 38025 43035 29493457
Leukaemia 27.47 14.12 29 38006 3781 29532711
Acute myocardial infarction 27.43 14.12 14 38021 48424 29488068
Abdominal pain 26.84 14.12 87 37948 135270 29401222
Bradyphrenia 26.76 14.12 30 38005 4184 29532308
Sexual dysfunction 26.51 14.12 35 38000 5779 29530713
Infection 26.45 14.12 36 37999 76715 29459777
Haemoptysis 26.17 14.12 4 38031 30546 29505946
Hyperthermia 26.15 14.12 45 37990 9385 29527107
Therapeutic product effect incomplete 26.13 14.12 110 37925 39195 29497297
Headache 26.12 14.12 125 37910 173882 29362610
Blood prolactin increased 26.01 14.12 19 38016 1515 29534977
Blunted affect 25.82 14.12 11 38024 301 29536191
Restless legs syndrome 25.80 14.12 38 37997 6946 29529546
Cerebrovascular accident 25.58 14.12 37 37998 76874 29459618
Pleural effusion 25.52 14.12 33 38002 71875 29464617
Plasma cell myeloma 25.46 14.12 8 38027 37107 29499385
Mucosal inflammation 25.17 14.12 5 38030 31590 29504902
Lethargy 24.84 14.12 105 37930 37475 29499017
Hypersensitivity 24.83 14.12 19 38016 52884 29483608
Cogwheel rigidity 24.79 14.12 17 38018 1226 29535266
Metabolic encephalopathy 24.71 14.12 27 38008 3660 29532832
Flight of ideas 24.61 14.12 11 38024 339 29536153
Blood sodium increased 24.60 14.12 23 38012 2591 29533901
Cardiac failure 24.59 14.12 40 37995 79247 29457245
Musculoskeletal pain 24.33 14.12 4 38031 28949 29507543
Otospondylomegaepiphyseal dysplasia 24.14 14.12 8 38027 106 29536386
Haemorrhage 24.10 14.12 14 38021 45058 29491434
Crying 24.07 14.12 32 38003 5319 29531173
Muscle spasms 24.00 14.12 29 38006 65053 29471439
Eosinophil count decreased 23.80 14.12 16 38019 1117 29535375
Neuropathy peripheral 23.79 14.12 34 38001 70993 29465499
Sleep disorder 23.55 14.12 77 37958 24309 29512183
Blood triglycerides increased 23.06 14.12 51 37984 12783 29523709
High-grade B-cell lymphoma 23.00 14.12 7 38028 69 29536423
Cerebral haemorrhage 22.99 14.12 6 38029 31420 29505072
Productive cough 22.80 14.12 6 38029 31253 29505239
Depressed mood 22.69 14.12 59 37976 16389 29520103
Hypotonia neonatal 22.50 14.12 16 38019 1223 29535269
Agranulocytosis 22.20 14.12 67 37968 20273 29516219
Drooling 21.79 14.12 23 38012 2998 29533494
Angioedema 21.68 14.12 7 38028 31908 29504584
Intentional product use issue 21.61 14.12 14 38021 42484 29494008
Self-injurious ideation 21.42 14.12 17 38018 1534 29534958
Hepatic failure 21.25 14.12 7 38028 31505 29504987
Altered state of consciousness 21.22 14.12 65 37970 19824 29516668
Pneumonitis 21.20 14.12 5 38030 28039 29508453
Diabetes mellitus 20.91 14.12 104 37931 39727 29496765
Apraxia 20.68 14.12 15 38020 1183 29535309
Anaphylactic reaction 20.68 14.12 5 38030 27568 29508924
Gait disturbance 20.54 14.12 163 37872 73186 29463306
Bone marrow failure 20.54 14.12 5 38030 27444 29509048
Urticaria 20.53 14.12 24 38011 54636 29481856
Floppy infant 20.27 14.12 7 38028 106 29536386
Erythema 20.02 14.12 42 37993 75564 29460928
Dyspnoea exertional 19.99 14.12 11 38024 36479 29500013
Encephalopathy 19.95 14.12 86 37949 30957 29505535
Depressive symptom 19.91 14.12 17 38018 1700 29534792
Movement disorder 19.90 14.12 42 37993 10195 29526297
Persistent depressive disorder 19.85 14.12 9 38026 287 29536205
Arthritis 19.85 14.12 4 38031 25015 29511477
Renal cyst 19.69 14.12 36 37999 7871 29528621
International normalised ratio increased 19.50 14.12 17 38018 44355 29492137
Wrong patient received product 19.43 14.12 19 38016 2263 29534229
Mood altered 19.03 14.12 36 37999 8075 29528417
Memory impairment 18.98 14.12 95 37940 36375 29500117
Drug hypersensitivity 18.96 14.12 37 37998 68369 29468123
Eosinophil count increased 18.92 14.12 34 38001 7335 29529157
Staphylococcal infection 18.85 14.12 7 38028 29233 29507259
Urinary incontinence 18.66 14.12 55 37980 16426 29520066
Antipsychotic drug level 18.59 14.12 4 38031 7 29536485
Oncocytoma 18.59 14.12 4 38031 7 29536485
Chest discomfort 18.59 14.12 19 38016 45964 29490528
Upper gastrointestinal haemorrhage 18.47 14.12 3 38032 21911 29514581
Psychotic symptom 18.47 14.12 15 38020 1399 29535093
Weight decreased 18.46 14.12 116 37919 150789 29385703
Prostate cancer 18.43 14.12 5 38030 25522 29510970
Social anxiety disorder 18.38 14.12 8 38027 231 29536261
Stupor 18.23 14.12 20 38015 2724 29533768
Dysphemia 18.14 14.12 15 38020 1435 29535057
Impulsive behaviour 18.10 14.12 17 38018 1926 29534566
Poor quality sleep 18.10 14.12 33 38002 7200 29529292
Herpes zoster 18.06 14.12 8 38027 30044 29506448
Convulsive threshold lowered 18.03 14.12 10 38025 493 29535999
Blood thyroid stimulating hormone increased 17.86 14.12 21 38014 3084 29533408
Speech sound disorder 17.85 14.12 7 38028 154 29536338
Haematoma 17.82 14.12 4 38031 23208 29513284
Syncope 17.76 14.12 50 37985 81321 29455171
Differential white blood cell count abnormal 17.72 14.12 14 38021 1255 29535237
Feelings of worthlessness 17.53 14.12 8 38027 259 29536233
Cerebral infarction 17.50 14.12 5 38030 24670 29511822
Hypoaesthesia 17.50 14.12 26 38009 53441 29483051
Angina pectoris 17.40 14.12 7 38028 27843 29508649
Kidney enlargement 17.33 14.12 11 38024 696 29535796
Inappropriate affect 17.28 14.12 10 38025 535 29535957
Libido increased 17.14 14.12 11 38024 710 29535782
Secondary tic 17.10 14.12 4 38031 12 29536480
Gambling disorder 17.06 14.12 15 38020 1560 29534932
Chest pain 17.03 14.12 80 37955 111893 29424599
Autonomic nervous system imbalance 16.98 14.12 18 38017 2358 29534134
Muscle twitching 16.86 14.12 34 38001 7992 29528500
Accidental death 16.86 14.12 17 38018 2101 29534391
Hallucination, olfactory 16.70 14.12 7 38028 184 29536308
Neutrophilia 16.61 14.12 22 38013 3644 29532848
Stomatitis 16.57 14.12 14 38021 37099 29499393
Nephrolithiasis 16.44 14.12 6 38029 25328 29511164
Abdominal distension 16.36 14.12 21 38014 45890 29490602
Hyperkalaemia 16.34 14.12 34 38001 61358 29475134
Electroconvulsive therapy 16.21 14.12 4 38031 16 29536476
Intention tremor 15.99 14.12 8 38027 319 29536173
Cerebral amyloid angiopathy 15.97 14.12 6 38029 117 29536375
Long QT syndrome 15.95 14.12 17 38018 2241 29534251
Haematuria 15.92 14.12 20 38015 44119 29492373
Oromandibular dystonia 15.88 14.12 9 38026 463 29536029
Hypertonia 15.86 14.12 22 38013 3807 29532685
Withdrawal syndrome 15.75 14.12 40 37995 10952 29525540
Thought blocking 15.61 14.12 6 38029 125 29536367
Atrioventricular block first degree 15.56 14.12 26 38009 5293 29531199
Lung disorder 15.44 14.12 10 38025 30352 29506140
Dysphoria 15.22 14.12 16 38019 2076 29534416
Platelet count decreased 15.21 14.12 76 37959 104596 29431896
Gastrooesophageal reflux disease 15.18 14.12 11 38024 31485 29505007
Bronchitis 15.17 14.12 15 38020 36853 29499639
Hallucination 15.16 14.12 104 37931 44608 29491884
Myalgia 15.05 14.12 47 37988 73972 29462520
Toxic cardiomyopathy 14.97 14.12 7 38028 240 29536252
Gastrectomy 14.93 14.12 6 38029 141 29536351
Acarodermatitis 14.91 14.12 8 38027 369 29536123
Bipolar II disorder 14.90 14.12 3 38032 3 29536489
Neoplasm progression 14.71 14.12 3 38032 18609 29517883
Hyperleukocytosis 14.65 14.12 14 38021 1621 29534871
Bradykinesia 14.57 14.12 20 38015 3427 29533065
Metastases to eye 14.40 14.12 5 38030 77 29536415
Major depression 14.36 14.12 21 38014 3814 29532678
Wheezing 14.29 14.12 13 38022 33227 29503265
Sinus arrest 14.13 14.12 13 38022 1434 29535058
Rhinorrhoea 14.13 14.12 5 38030 21514 29514978

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 1896.49 12.65 2198 71701 361315 64063518
Tremor 1155.33 12.65 1113 72786 147117 64277716
Antipsychotic drug level increased 1125.02 12.65 359 73540 4756 64420077
Neuroleptic malignant syndrome 1111.74 12.65 552 73347 24444 64400389
Nephrogenic diabetes insipidus 925.94 12.65 247 73652 1640 64423193
Mania 748.76 12.65 368 73531 15918 64408915
Drug interaction 695.00 12.65 1376 72523 360707 64064126
Extrapyramidal disorder 679.62 12.65 366 73533 19186 64405647
Hypomania 462.03 12.65 191 73708 5463 64419370
Antipsychotic drug level above therapeutic 427.25 12.65 135 73764 1726 64423107
Agitation 413.74 12.65 508 73391 87859 64336974
Psychotic disorder 409.73 12.65 330 73569 34248 64390585
Parkinsonism 387.94 12.65 228 73671 14145 64410688
Ataxia 378.43 12.65 263 73636 21821 64403012
Hyperparathyroidism 374.47 12.65 136 73763 2716 64422117
Serotonin syndrome 371.01 12.65 329 73570 38953 64385880
Confusional state 362.19 12.65 872 73027 260272 64164561
Schizophrenia 354.64 12.65 197 73702 10971 64413862
Suicide attempt 351.53 12.65 420 73479 70587 64354246
Sopor 334.37 12.65 275 73624 29386 64395447
Akathisia 327.61 12.65 189 73710 11321 64413512
Sedation 325.10 12.65 313 73586 41149 64383684
Dysarthria 323.42 12.65 369 73530 59037 64365796
Completed suicide 314.91 12.65 753 73146 223661 64201172
Suicidal ideation 313.72 12.65 384 73515 66158 64358675
Dyspnoea 272.89 12.65 254 73645 718420 63706413
Salivary hypersecretion 269.97 12.65 170 73729 11943 64412890
Tardive dyskinesia 267.32 12.65 153 73746 9025 64415808
Muscle rigidity 253.28 12.65 188 73711 17285 64407548
Pain 249.88 12.65 164 73735 553347 63871486
Diabetes insipidus 243.68 12.65 114 73785 4407 64420426
Intentional self-injury 240.47 12.65 226 73673 28818 64396015
Hypernatraemia 236.99 12.65 157 73742 12032 64412801
Aggression 232.89 12.65 276 73623 45956 64378877
Granulocytopenia 228.86 12.65 145 73754 10295 64414538
Bipolar disorder 227.70 12.65 124 73775 6637 64418196
Arthralgia 220.73 12.65 116 73783 442144 63982689
Psychomotor hyperactivity 219.63 12.65 160 73739 14291 64410542
Catatonia 219.18 12.65 126 73773 7494 64417339
Somnolence 213.42 12.65 613 73286 203032 64221801
Overdose 204.02 12.65 517 73382 159049 64265784
Myoclonus 203.25 12.65 193 73706 24925 64399908
Obsessive-compulsive disorder 198.16 12.65 101 73798 4717 64420116
Intentional overdose 191.31 12.65 358 73541 89586 64335247
Delirium 189.63 12.65 308 73591 68886 64355947
Irritability 187.75 12.65 221 73678 36525 64388308
Delusion 186.40 12.65 159 73740 17855 64406978
Hallucination, auditory 182.44 12.65 153 73746 16786 64408047
Disorientation 171.65 12.65 262 73637 55566 64369267
Dyskinesia 167.53 12.65 216 73683 39172 64385661
Disturbance in attention 166.55 12.65 220 73679 40854 64383979
Drug abuse 163.03 12.65 423 73476 131951 64292882
Drug level increased 154.08 12.65 193 73706 34003 64390830
Hypothyroidism 146.30 12.65 205 73694 40252 64384581
Hyperreflexia 146.09 12.65 95 73804 7053 64417780
Mental status changes 145.98 12.65 256 73643 60906 64363927
Cough 142.28 12.65 85 73814 302063 64122770
Febrile neutropenia 140.85 12.65 23 73876 187634 64237199
Rheumatoid arthritis 140.70 12.65 13 73886 164281 64260552
Anaemia 138.39 12.65 138 73761 378542 64046291
Polyuria 133.68 12.65 113 73786 12530 64412303
Restlessness 132.71 12.65 194 73705 39591 64385242
Dystonia 132.18 12.65 134 73765 18731 64406102
Infusion related reaction 130.74 12.65 17 73882 164450 64260383
Coma 130.19 12.65 301 73598 87314 64337519
Depressed level of consciousness 129.04 12.65 287 73612 81149 64343684
Altered state of consciousness 128.14 12.65 186 73713 37716 64387117
Speech disorder 127.79 12.65 212 73687 48229 64376604
Neurotoxicity 127.20 12.65 157 73742 27247 64397586
Antipsychotic drug level below therapeutic 125.70 12.65 46 73853 939 64423894
Weight increased 122.84 12.65 527 73372 212821 64212012
Pruritus 122.15 12.65 107 73792 312293 64112540
Abnormal behaviour 119.53 12.65 169 73730 33453 64391380
Electrocardiogram QT prolonged 119.19 12.65 274 73625 79174 64345659
Polydipsia 118.07 12.65 77 73822 5744 64419089
Joint swelling 115.62 12.65 51 73848 215331 64209502
Pain in extremity 114.69 12.65 107 73792 302978 64121855
Hypersensitivity 111.13 12.65 43 73856 196409 64228424
Schizoaffective disorder 110.95 12.65 48 73851 1539 64423294
Pleurothotonus 108.68 12.65 53 73846 2249 64422584
Back pain 106.11 12.65 79 73820 250092 64174741
Cognitive disorder 104.51 12.65 209 73690 54878 64369955
Peripheral swelling 103.92 12.65 55 73844 209098 64215735
Brugada syndrome 103.85 12.65 41 73858 1037 64423796
Bradyphrenia 101.36 12.65 85 73814 9321 64415512
Cerebellar syndrome 100.88 12.65 66 73833 4950 64419883
Fatigue 100.12 12.65 480 73419 748250 63676583
Synovitis 99.71 12.65 3 73896 99087 64325746
Malignant neoplasm progression 99.16 12.65 8 73891 112863 64311970
Disease progression 98.52 12.65 21 73878 141659 64283174
Euphoric mood 97.93 12.65 72 73827 6519 64418314
Bruxism 96.48 12.65 57 73842 3567 64421266
Swelling 95.83 12.65 32 73867 160186 64264647
Blood creatine phosphokinase increased 94.57 12.65 208 73691 58350 64366483
Rash 94.01 12.65 245 73654 458304 63966529
Nephropathy 92.89 12.65 77 73822 8309 64416524
Death 90.72 12.65 269 73630 482436 63942397
Nasopharyngitis 89.67 12.65 57 73842 196016 64228817
White blood cell count increased 89.61 12.65 219 73680 65795 64359038
Sinusitis 89.29 12.65 28 73871 145900 64278933
Apathy 88.37 12.65 85 73814 11147 64413686
Logorrhoea 88.02 12.65 56 73843 4003 64420830
Arthropathy 86.03 12.65 17 73882 120950 64303883
Atrial fibrillation 84.96 12.65 45 73854 171044 64253789
Leukocytosis 84.93 12.65 154 73745 37586 64387247
Pneumonia 84.19 12.65 343 73556 559233 63865600
Treatment noncompliance 83.71 12.65 166 73733 43316 64381517
Priapism 81.71 12.65 53 73846 3917 64420916
Depression 81.42 12.65 420 73479 182871 64241962
Hypercalcaemia 80.85 12.65 136 73763 31280 64393553
Interstitial lung disease 80.36 12.65 9 73890 97723 64327110
Neutrophil count increased 79.97 12.65 120 73779 25054 64399779
Camptocormia 78.63 12.65 27 73872 454 64424379
Jaundice cholestatic 78.60 12.65 71 73828 8599 64416234
Cardiac failure congestive 78.22 12.65 26 73873 130554 64294279
Grandiosity 78.13 12.65 28 73871 537 64424296
Depressed mood 77.06 12.65 155 73744 40857 64383976
Coordination abnormal 76.41 12.65 90 73809 14874 64409959
Affect lability 76.39 12.65 71 73828 8919 64415914
Cogwheel rigidity 76.28 12.65 45 73854 2808 64422025
Libido increased 74.99 12.65 38 73861 1752 64423081
Stomatitis 74.66 12.65 17 73882 109588 64315245
Enuresis 74.58 12.65 44 73855 2746 64422087
Oppositional defiant disorder 74.50 12.65 26 73873 460 64424373
Encephalopathy 74.43 12.65 190 73709 58629 64366204
Anxiety 73.75 12.65 440 73459 202209 64222624
Renal cyst 73.33 12.65 81 73818 12489 64412344
Mutism 73.22 12.65 39 73860 1995 64422838
Headache 72.62 12.65 336 73563 529131 63895702
Systemic lupus erythematosus 72.57 12.65 4 73895 77608 64347225
Alopecia 71.94 12.65 51 73848 165639 64259194
Gastrointestinal haemorrhage 71.49 12.65 31 73868 132281 64292552
Homicidal ideation 70.78 12.65 45 73854 3212 64421621
Poisoning deliberate 70.48 12.65 82 73817 13376 64411457
Choreoathetosis 70.37 12.65 34 73865 1413 64423420
Infection 70.18 12.65 65 73834 184815 64240018
Mental disorder 70.08 12.65 116 73783 26329 64398504
Clonus 69.90 12.65 57 73842 6010 64418823
Parathyroid tumour benign 69.05 12.65 27 73872 665 64424168
Paranoia 68.45 12.65 89 73810 16263 64408570
Bradykinesia 68.05 12.65 58 73841 6502 64418331
Drug intolerance 66.86 12.65 70 73829 187922 64236911
Poisoning 66.25 12.65 102 73797 21777 64403056
Arthritis 65.77 12.65 9 73890 83805 64341028
Body tinea 64.76 12.65 31 73868 1262 64423571
Hyperprolactinaemia 64.02 12.65 46 73853 4019 64420814
Hyperparathyroidism primary 63.85 12.65 22 73877 374 64424459
Aphasia 63.45 12.65 143 73756 40763 64384070
Sepsis 63.24 12.65 104 73795 230237 64194596
Decreased eye contact 63.02 12.65 26 73873 739 64424094
Thrombocytopenia 62.42 12.65 100 73799 223701 64201132
Stupor 61.87 12.65 53 73846 5982 64418851
Urticaria 61.80 12.65 47 73852 147270 64277563
Bipolar I disorder 61.07 12.65 33 73866 1738 64423095
Pyramidal tract syndrome 60.45 12.65 23 73876 525 64424308
Contraindicated product administered 60.29 12.65 24 73875 107805 64317028
Electroencephalogram abnormal 60.19 12.65 49 73850 5154 64419679
Thinking abnormal 59.83 12.65 70 73829 11486 64413347
Hand deformity 59.42 12.65 3 73896 62768 64362065
Abdominal pain 59.37 12.65 173 73726 312202 64112631
Postural tremor 59.15 12.65 23 73876 558 64424275
Myocardial infarction 58.67 12.65 62 73837 165759 64259074
Insomnia 58.12 12.65 407 73492 197429 64227404
Drug level above therapeutic 57.67 12.65 54 73845 6847 64417986
Drooling 57.17 12.65 48 73851 5271 64419562
Gait disturbance 57.08 12.65 365 73534 171790 64253043
Glossodynia 55.68 12.65 5 73894 64691 64360142
Diarrhoea 55.63 12.65 545 73354 722159 63702674
Increased appetite 55.11 12.65 63 73836 10083 64414750
Chronic kidney disease 54.48 12.65 168 73731 57751 64367082
Hostility 54.31 12.65 33 73866 2174 64422659
Withdrawal syndrome 54.30 12.65 97 73802 23395 64401438
Neuropathy peripheral 53.93 12.65 34 73865 117491 64307342
Disinhibition 53.81 12.65 33 73866 2210 64422623
Myocarditis 53.79 12.65 81 73818 16962 64407871
Psychiatric decompensation 53.45 12.65 34 73865 2429 64422404
Bronchitis 53.38 12.65 29 73870 108714 64316119
Chest pain 53.05 12.65 120 73779 235860 64188973
Drug reaction with eosinophilia and systemic symptoms 52.62 12.65 159 73740 54058 64370775
Injection site erythema 52.37 12.65 9 73890 70791 64354042
Abdominal discomfort 52.22 12.65 80 73819 182242 64242591
Wound 51.80 12.65 12 73887 76465 64348368
Anticholinergic syndrome 50.96 12.65 34 73865 2635 64422198
Pericarditis 50.78 12.65 6 73893 62510 64362323
Pressure of speech 50.13 12.65 24 73875 977 64423856
Hypertonia 50.01 12.65 48 73851 6277 64418556
Leukopenia 49.87 12.65 239 73660 101003 64323830
Behaviour disorder 49.48 12.65 41 73858 4421 64420412
Depressive symptom 49.21 12.65 41 73858 4455 64420378
Intentional product use issue 48.94 12.65 24 73875 95340 64329493
Poor quality sleep 48.70 12.65 82 73817 18869 64405964
Dystonic tremor 48.18 12.65 15 73884 182 64424651
Delusion of grandeur 48.10 12.65 20 73879 580 64424253
Galactorrhoea 47.45 12.65 35 73864 3184 64421649
Glucose tolerance impaired 47.39 12.65 47 73852 6396 64418437
International normalised ratio increased 46.98 12.65 16 73883 79151 64345682
Pancytopenia 46.97 12.65 57 73842 143252 64281581
Lethargy 46.94 12.65 186 73713 72408 64352425
General physical health deterioration 46.72 12.65 103 73796 204322 64220511
Distractibility 46.68 12.65 20 73879 626 64424207
Persistent depressive disorder 46.58 12.65 23 73876 1003 64423830
Blood sodium increased 46.42 12.65 39 73860 4287 64420546
Ascites 45.59 12.65 8 73891 61993 64362840
Abdominal pain upper 45.30 12.65 82 73817 174948 64249885
Mental impairment 45.07 12.65 73 73826 16270 64408563
Hyperthermia 45.00 12.65 71 73828 15479 64409354
Psychiatric symptom 44.74 12.65 45 73854 6228 64418605
Blood prolactin increased 44.60 12.65 35 73864 3493 64421340
Anger 44.35 12.65 71 73828 15670 64409163
Mucosal inflammation 44.05 12.65 9 73890 62575 64362258
Musculoskeletal pain 43.98 12.65 19 73880 81275 64343558
Urinary incontinence 43.89 12.65 115 73784 36036 64388797
Infection susceptibility increased 43.28 12.65 31 73868 2695 64422138
Bundle branch block right 43.15 12.65 56 73843 10213 64414620
Productive cough 43.09 12.65 15 73884 73188 64351645
Muscle contractions involuntary 43.03 12.65 33 73866 3184 64421649
Balance disorder 42.70 12.65 200 73699 83726 64341107
Metabolic syndrome 42.65 12.65 29 73870 2319 64422514
Impaired healing 41.94 12.65 9 73890 60464 64364369
Pleural effusion 41.83 12.65 50 73849 126509 64298324
Inhibitory drug interaction 41.63 12.65 34 73865 3593 64421240
Renal oncocytoma 41.62 12.65 11 73888 70 64424763
Action tremor 41.07 12.65 16 73883 390 64424443
Cerebrovascular accident 40.72 12.65 59 73840 137524 64287309
Drug hypersensitivity 40.72 12.65 138 73761 237677 64187156
Haemorrhage 40.67 12.65 20 73879 79331 64345502
Blister 40.61 12.65 21 73878 80946 64343887
Asthma 40.41 12.65 30 73869 95195 64329638
Trismus 40.28 12.65 38 73861 4863 64419970
Oedema peripheral 40.27 12.65 116 73783 210201 64214632
Blunted affect 40.26 12.65 16 73883 412 64424421
Therapeutic product effect decreased 39.82 12.65 44 73855 115307 64309526
Acute myocardial infarction 39.82 12.65 15 73884 69703 64355130
Gestational diabetes 39.69 12.65 40 73859 5550 64419283
Electrocardiogram T wave abnormal 39.66 12.65 32 73867 3324 64421509
Personality disorder 39.63 12.65 37 73862 4674 64420159
Tachycardia 39.46 12.65 300 73599 149279 64275554
Melaena 39.18 12.65 7 73892 53541 64371292
Sexually inappropriate behaviour 38.87 12.65 16 73883 452 64424381
Hypothermia 38.44 12.65 76 73823 19780 64405053
Muscle twitching 38.34 12.65 74 73825 18924 64405909
Psychomotor skills impaired 37.86 12.65 33 73866 3812 64421021
Epistaxis 37.81 12.65 34 73865 98097 64326736
Septic shock 37.76 12.65 39 73860 105398 64319435
Failure to suspend medication 37.60 12.65 15 73884 390 64424443
Miosis 37.60 12.65 60 73839 13206 64411627
Abulia 37.58 12.65 19 73880 872 64423961
Visuospatial deficit 37.51 12.65 9 73890 36 64424797
Cardio-respiratory arrest 37.26 12.65 216 73683 98177 64326656
Cerebellar atrophy 37.10 12.65 20 73879 1048 64423785
Memory impairment 37.06 12.65 195 73704 85487 64339346
Resting tremor 37.01 12.65 22 73877 1392 64423441
Malaise 36.97 12.65 284 73615 395963 64028870
Injection site pain 36.83 12.65 44 73855 111364 64313469
Acute kidney injury 36.66 12.65 720 73179 448520 63976313
Electrocardiogram T wave inversion 36.55 12.65 36 73863 4858 64419975
Antipsychotic drug level decreased 36.54 12.65 19 73880 925 64423908
Decreased appetite 36.42 12.65 182 73717 281107 64143726
Cardiac failure 36.08 12.65 60 73839 132313 64292520
Oculogyric crisis 36.08 12.65 27 73872 2511 64422322
Schizoaffective disorder bipolar type 36.06 12.65 11 73888 124 64424709
Pneumonitis 35.96 12.65 7 73892 50358 64374475
Nausea 35.78 12.65 660 73239 785140 63639693
Mood altered 35.68 12.65 65 73834 15914 64408919
Treatment failure 35.65 12.65 49 73850 116767 64308066
Anaphylactic reaction 35.65 12.65 17 73882 68647 64356186
Persecutory delusion 35.64 12.65 33 73866 4125 64420708
Asterixis 35.53 12.65 26 73873 2337 64422496
Hallucination 35.24 12.65 171 73728 72617 64352216
Hypokinesia 35.16 12.65 66 73833 16530 64408303
Agranulocytosis 35.12 12.65 110 73789 38119 64386714
Long QT syndrome 35.08 12.65 36 73863 5103 64419730
Haemodialysis 35.05 12.65 67 73832 17010 64407823
Electroconvulsive therapy 35.01 12.65 10 73889 88 64424745
Soft tissue injury 34.77 12.65 22 73877 1557 64423276
Platelet count decreased 34.73 12.65 89 73810 167622 64257211
Gastrointestinal disorder 34.66 12.65 31 73868 89678 64335155
Hyperthyroidism 34.49 12.65 69 73830 18110 64406723
Language disorder 34.44 12.65 27 73872 2690 64422143
Dyspnoea exertional 34.27 12.65 21 73878 73709 64351124
Electrocardiogram abnormal 34.20 12.65 58 73841 13423 64411410
Rhinorrhoea 34.09 12.65 13 73886 59956 64364877
Osteoarthritis 33.94 12.65 15 73884 63321 64361512
Electrocardiogram QRS complex prolonged 33.64 12.65 47 73852 9197 64415636
Psychomotor retardation 33.26 12.65 35 73864 5108 64419725
Lung disorder 33.13 12.65 14 73885 60686 64364147
Feeling guilty 33.11 12.65 17 73882 806 64424027
Sleep-related eating disorder 33.09 12.65 16 73883 666 64424167
Erythema 33.08 12.65 107 73792 186963 64237870
Coronary artery disease 32.88 12.65 14 73885 60419 64364414
Mobility decreased 32.76 12.65 30 73869 85810 64339023
Impulsive behaviour 32.76 12.65 26 73873 2637 64422196
Self-injurious ideation 32.62 12.65 28 73871 3169 64421664
Acute psychosis 32.59 12.65 30 73869 3722 64421111
Goitre 32.44 12.65 34 73865 4939 64419894
Otospondylomegaepiphyseal dysplasia 32.41 12.65 8 73891 37 64424796
Haemoglobin decreased 32.16 12.65 115 73784 194948 64229885
Sluggishness 32.14 12.65 36 73863 5634 64419199
Hypomagnesaemia 31.86 12.65 3 73896 37373 64387460
Plasma cell myeloma 31.66 12.65 7 73892 46068 64378765
Adams-Stokes syndrome 31.63 12.65 10 73889 128 64424705
Hyperkinesia 31.63 12.65 25 73874 2521 64422312
Blood pressure fluctuation 31.63 12.65 10 73889 51861 64372972
Social avoidant behaviour 31.24 12.65 32 73867 4525 64420308
Nodal rhythm 31.02 12.65 26 73873 2848 64421985
Blood thyroid stimulating hormone decreased 31.02 12.65 34 73865 5196 64419637
Sleep disorder 30.88 12.65 143 73756 59566 64365267
Neoplasm progression 30.75 12.65 5 73894 40959 64383874
Muscle spasms 30.63 12.65 73 73826 140950 64283883
Major depression 30.34 12.65 41 73858 7775 64417058
Restless legs syndrome 30.15 12.65 63 73836 17053 64407780
Hypoxia 30.01 12.65 34 73865 88115 64336718
Speech sound disorder 29.99 12.65 8 73891 53 64424780
Patient restraint 29.96 12.65 9 73890 96 64424737
Haematoma 29.88 12.65 8 73891 46242 64378591
Paraesthesia 29.72 12.65 69 73830 134453 64290380
Differential white blood cell count abnormal 29.69 12.65 21 73878 1789 64423044
Osteonecrosis of jaw 29.59 12.65 5 73894 39820 64385013
Upper gastrointestinal haemorrhage 29.57 12.65 3 73896 35217 64389616
Chest discomfort 29.49 12.65 55 73844 116051 64308782
Protein C increased 29.46 12.65 9 73890 102 64424731
Oncocytoma 29.38 12.65 7 73892 27 64424806
Hallucination, olfactory 29.34 12.65 13 73886 442 64424391
Influenza 29.30 12.65 48 73851 106483 64318350
Dysphemia 29.18 12.65 26 73873 3093 64421740
Tachyphrenia 29.02 12.65 21 73878 1855 64422978
Injection site swelling 28.99 12.65 6 73893 41347 64383486
Neutrophilia 28.90 12.65 37 73862 6657 64418176
Post-traumatic neck syndrome 28.76 12.65 21 73878 1881 64422952
Echolalia 28.64 12.65 12 73887 355 64424478
Urinary retention 28.59 12.65 122 73777 49079 64375754
Feelings of worthlessness 28.51 12.65 13 73886 473 64424360
Metabolic encephalopathy 28.01 12.65 40 73859 7985 64416848
Sinus bradycardia 27.97 12.65 73 73826 22820 64402013
Hyporeflexia 27.89 12.65 26 73873 3278 64421555
Affective disorder 27.83 12.65 36 73863 6544 64418289
Thrombosis 27.79 12.65 24 73875 70618 64354215
Movement disorder 27.75 12.65 71 73828 21929 64402904
Skin ulcer 27.67 12.65 8 73891 43966 64380867
Lower respiratory tract infection 27.57 12.65 41 73858 94573 64330260
Bone pain 27.56 12.65 10 73889 47562 64377271
Hyperleukocytosis 27.45 12.65 21 73878 2019 64422814
Antipsychotic drug level 27.43 12.65 6 73893 14 64424819
Papillary thyroid cancer 27.34 12.65 22 73877 2276 64422557
Haemoptysis 27.27 12.65 11 73888 49037 64375796
Upper respiratory tract infection 27.11 12.65 26 73873 72759 64352074
Parkinsonian gait 27.01 12.65 15 73884 834 64423999
Psoriatic arthropathy 27.01 12.65 8 73891 43273 64381560
Angina pectoris 26.94 12.65 9 73890 45072 64379761
Drug withdrawal syndrome 26.89 12.65 88 73811 31203 64393630
Dysphoria 26.85 12.65 29 73870 4359 64420474
Poverty of speech 26.34 12.65 13 73886 566 64424267
Blood pressure increased 26.32 12.65 105 73794 172447 64252386
Hyperhidrosis 26.22 12.65 238 73661 124682 64300151
Convulsive threshold lowered 26.21 12.65 15 73884 884 64423949
Prescribed overdose 26.04 12.65 66 73833 20265 64404568
Cerebral haemorrhage 25.99 12.65 13 73886 51077 64373756
Sternal fracture 25.65 12.65 21 73878 2226 64422607
Staphylococcal infection 25.62 12.65 13 73886 50665 64374168
Weight decreased 25.59 12.65 207 73692 285532 64139301
Sinus arrest 25.48 12.65 24 73875 3066 64421767
Deprescribing error 25.42 12.65 6 73893 22 64424811
Gaze palsy 25.34 12.65 22 73877 2528 64422305
Oxygen saturation decreased 25.30 12.65 53 73846 107123 64317710
Antidepressant drug level increased 25.24 12.65 11 73888 359 64424474
Acquired cystic kidney disease 25.21 12.65 7 73892 55 64424778
Impaired quality of life 25.20 12.65 34 73865 6437 64418396
Neurological symptom 25.13 12.65 35 73864 6829 64418004
Fluid retention 25.00 12.65 19 73880 59587 64365246
Hypoaesthesia 24.98 12.65 79 73820 139029 64285804
Induced abortion failed 24.67 12.65 9 73890 182 64424651
Hereditary ataxia 24.62 12.65 6 73893 26 64424807
Respiratory arrest 24.59 12.65 123 73776 52862 64371971
Wheezing 24.38 12.65 34 73865 80545 64344288
Status epilepticus 24.37 12.65 67 73832 21596 64403237
Diverticulitis 24.35 12.65 7 73892 38611 64386222
Injection site bruising 24.05 12.65 6 73893 36367 64388466
Discomfort 23.61 12.65 35 73864 80843 64343990
Fibromyalgia 23.43 12.65 6 73893 35725 64389108
Toxic encephalopathy 23.29 12.65 41 73858 9774 64415059
High-grade B-cell lymphoma 23.02 12.65 7 73892 78 64424755
Hyperammonaemia 23.02 12.65 41 73858 9863 64414970
Nystagmus 22.98 12.65 39 73860 9029 64415804
Lactic acidosis 22.80 12.65 22 73877 61388 64363445
Product use issue 22.70 12.65 93 73806 151622 64273211
Nephropathy toxic 22.58 12.65 57 73842 17457 64407376
Flat affect 22.57 12.65 18 73881 1839 64422994
Obesity 22.54 12.65 63 73836 20499 64404334
Chronic obstructive pulmonary disease 22.49 12.65 29 73870 71019 64353814
Substance abuse 22.29 12.65 39 73860 9253 64415580
Gambling disorder 22.25 12.65 18 73881 1876 64422957
Haematuria 22.06 12.65 22 73877 60449 64364384
Seizure 22.06 12.65 290 73609 166602 64258231
Hypokalaemia 22.05 12.65 69 73830 121834 64302999
Apraxia 21.77 12.65 20 73879 2475 64422358
Conversion disorder 21.61 12.65 17 73882 1702 64423131
Osteomyelitis 21.55 12.65 3 73896 27584 64397249
Progressive supranuclear palsy 21.18 12.65 7 73892 104 64424729
Clostridium difficile colitis 21.17 12.65 3 73896 27220 64397613
Haematochezia 21.10 12.65 27 73872 66346 64358487
Flight of ideas 21.10 12.65 12 73887 699 64424134
Cerebellar ataxia 21.07 12.65 17 73882 1766 64423067
Drug level decreased 21.04 12.65 43 73856 11460 64413373
Gastric disorder 20.96 12.65 4 73895 29193 64395640
Hallucinations, mixed 20.88 12.65 30 73869 6022 64418811
Sexual dysfunction 20.77 12.65 31 73868 6440 64418393
Thought blocking 20.73 12.65 8 73891 190 64424643
Hyperkalaemia 20.67 12.65 54 73845 101075 64323758
Mood swings 20.62 12.65 55 73844 17413 64407420
Blood creatinine increased 20.55 12.65 242 73657 135540 64289293
Water intoxication 20.50 12.65 12 73887 738 64424095
Throat irritation 20.49 12.65 6 73893 32705 64392128
Negativism 20.35 12.65 12 73887 748 64424085
Inflammation 20.31 12.65 27 73872 65273 64359560
Myalgia 20.29 12.65 103 73796 158514 64266319
Oropharyngeal pain 20.10 12.65 45 73854 88822 64336011
Clear cell renal cell carcinoma 20.06 12.65 18 73881 2161 64422672
Cystitis 20.05 12.65 12 73887 42663 64382170
Cholelithiasis 19.97 12.65 104 73795 45402 64379431
Encopresis 19.94 12.65 7 73892 126 64424707
Mydriasis 19.92 12.65 50 73849 15262 64409571
Localised infection 19.90 12.65 5 73894 30156 64394677
Ileus paralytic 19.77 12.65 35 73864 8380 64416453
Reflexes abnormal 19.64 12.65 12 73887 798 64424035
Atrioventricular block first degree 19.48 12.65 40 73859 10694 64414139
Dry skin 19.38 12.65 18 73881 51143 64373690
Pulmonary oedema 19.34 12.65 38 73861 78636 64346197
Hepatic failure 19.25 12.65 21 73878 55373 64369460
Myocarditis septic 19.17 12.65 5 73894 30 64424803
Delusion of reference 19.12 12.65 7 73892 143 64424690
Suspected suicide 19.06 12.65 35 73864 8619 64416214
Eosinophil count decreased 18.87 12.65 19 73880 2633 64422200
Urinary tract infection 18.84 12.65 172 73727 231424 64193409
Thyroiditis 18.84 12.65 22 73877 3602 64421231
Lactate pyruvate ratio increased 18.82 12.65 6 73893 79 64424754
Rectal haemorrhage 18.79 12.65 26 73873 61791 64363042
Bacteraemia 18.67 12.65 4 73895 26907 64397926
Intention tremor 18.67 12.65 11 73888 685 64424148
Ideas of reference 18.64 12.65 7 73892 154 64424679
Thyrotoxic crisis 18.43 12.65 13 73886 1103 64423730
Femur fracture 18.42 12.65 8 73891 34127 64390706
Muscle contracture 18.34 12.65 17 73882 2128 64422705
Abdominal distension 18.31 12.65 53 73846 95941 64328892
Torticollis 18.12 12.65 17 73882 2160 64422673
Autonomic nervous system imbalance 18.09 12.65 23 73876 4109 64420724
Cerebral atrophy 18.03 12.65 31 73868 7254 64417579
Osteonecrosis 18.01 12.65 5 73894 28224 64396609
Therapeutic product effect variable 18.01 12.65 15 73884 1629 64423204
Angioedema 17.80 12.65 27 73872 61794 64363039
Oscillopsia 17.73 12.65 7 73892 177 64424656
Myelosuppression 17.68 12.65 3 73896 23827 64401006
Histrionic personality disorder 17.50 12.65 5 73894 44 64424789
Social anxiety disorder 17.25 12.65 9 73890 441 64424392
Ear infection 17.25 12.65 3 73896 23401 64401432
Pain in jaw 17.08 12.65 13 73886 40742 64384091
Respiratory distress 16.94 12.65 21 73878 52310 64372523
Irregular sleep wake rhythm disorder 16.94 12.65 8 73891 316 64424517
Hallucination, visual 16.93 12.65 70 73829 27764 64397069
Hip fracture 16.92 12.65 5 73894 27094 64397739
Blood thyroid stimulating hormone increased 16.92 12.65 31 73868 7623 64417210
Mouth ulceration 16.89 12.65 8 73891 32436 64392397
Secondary tic 16.88 12.65 4 73895 15 64424818
Knee arthroplasty 16.83 12.65 5 73894 26994 64397839
Device related infection 16.81 12.65 7 73892 30619 64394214
Hepatotoxicity 16.62 12.65 90 73809 39872 64384961
Product dose omission issue 16.55 12.65 143 73756 194604 64230229
Merycism 16.52 12.65 7 73892 213 64424620
Megacolon 16.51 12.65 19 73880 3063 64421770
Compulsions 16.43 12.65 8 73891 338 64424495
Limbic encephalitis 16.43 12.65 10 73889 661 64424172
Urine output increased 16.40 12.65 15 73884 1846 64422987
Blood citric acid increased 16.19 12.65 5 73894 59 64424774
Injection site haemorrhage 16.06 12.65 4 73895 24274 64400559
Unmasking of previously unidentified disease 15.95 12.65 14 73885 1633 64423200
Clostridium difficile infection 15.85 12.65 11 73888 36152 64388681
Diabetic hyperosmolar coma 15.83 12.65 10 73889 706 64424127
Nephrolithiasis 15.81 12.65 16 73883 43667 64381166
Pulmonary mass 15.81 12.65 4 73895 24012 64400821
Osteoporosis 15.71 12.65 15 73884 42065 64382768
Fungal infection 15.58 12.65 10 73889 34241 64390592
Dysphagia 15.55 12.65 189 73710 106623 64318210
Antidepressant drug level above therapeutic 15.53 12.65 9 73890 543 64424290
Off label use 15.50 12.65 581 73318 632225 63792608
Rhabdomyolysis 15.46 12.65 167 73732 91559 64333274
Flatulence 15.43 12.65 11 73888 35655 64389178
Small intestinal obstruction 15.37 12.65 4 73895 23569 64401264
Dry eye 15.35 12.65 7 73892 29012 64395821
Activation syndrome 15.12 12.65 7 73892 264 64424569
Impaired work ability 15.11 12.65 45 73854 15174 64409659
Sleep apnoea syndrome 15.09 12.65 71 73828 29761 64395072
Bradycardia 15.02 12.65 204 73695 118015 64306818
Coagulopathy 14.96 12.65 9 73890 31911 64392922
Cerebral infarction 14.89 12.65 15 73884 41029 64383804
Psychotic disorder due to a general medical condition 14.88 12.65 7 73892 274 64424559
Staring 14.87 12.65 16 73883 2394 64422439
Psoriasis 14.87 12.65 38 73861 71665 64353168
Blood pressure systolic increased 14.83 12.65 21 73878 49432 64375401
Generalised tonic-clonic seizure 14.75 12.65 87 73812 39770 64385063
Bone marrow failure 14.74 12.65 20 73879 47932 64376901
Eosinophilia 14.67 12.65 84 73815 37992 64386841
Psychotic symptom 14.63 12.65 15 73884 2123 64422710
Hepatic cirrhosis 14.45 12.65 6 73893 26292 64398541
Autoimmune thyroiditis 14.45 12.65 19 73880 3509 64421324
Blood triglycerides increased 14.40 12.65 51 73848 18815 64406018
Metabolic disorder 14.34 12.65 29 73870 7668 64417165
Consciousness fluctuating 14.27 12.65 13 73886 1592 64423241
Maternal exposure during pregnancy 14.20 12.65 59 73840 95825 64329008
Thyroid function test abnormal 14.18 12.65 17 73882 2862 64421971
Pneumocystis jirovecii pneumonia 14.10 12.65 7 73892 27627 64397206
Basal cell carcinoma 14.03 12.65 9 73890 30829 64394004
Fluid intake reduced 14.03 12.65 23 73876 5177 64419656
Oral pain 13.98 12.65 7 73892 27486 64397347
Breast cancer 13.97 12.65 8 73891 29140 64395693
Acute myeloid leukaemia 13.95 12.65 7 73892 27456 64397377
Potentiating drug interaction 13.94 12.65 29 73870 7823 64417010
Ischaemic stroke 13.87 12.65 8 73891 29027 64395806
Diabetic coma 13.82 12.65 11 73888 1120 64423713
Injection site reaction 13.81 12.65 20 73879 46644 64378189
Tic 13.78 12.65 16 73883 2603 64422230
Parasomnia 13.74 12.65 8 73891 487 64424346
Impaired self-care 13.65 12.65 15 73884 2298 64422535
Decreased interest 13.61 12.65 18 73881 3342 64421491
Pulmonary arterial hypertension 13.60 12.65 6 73893 25361 64399472
Anaphylactic shock 13.59 12.65 9 73890 30319 64394514
Bronchospasm 13.54 12.65 4 73895 21678 64403155
Incoherent 13.48 12.65 27 73872 7091 64417742
Bone density decreased 13.47 12.65 33 73866 9919 64414914
Cyclothymic disorder 13.46 12.65 6 73893 207 64424626
Slow speech 13.42 12.65 14 73885 2023 64422810
Syncope 13.28 12.65 116 73783 157519 64267314
Cardiac hypertrophy 13.24 12.65 12 73887 1459 64423374
Obstructive airways disorder 13.22 12.65 5 73894 23180 64401653
Tension 13.20 12.65 19 73880 3821 64421012
Hypersexuality 13.19 12.65 12 73887 1467 64423366
Toxic cardiomyopathy 13.16 12.65 7 73892 357 64424476
Dialysis 13.14 12.65 46 73853 16874 64407959
Neuropsychiatric symptoms 13.12 12.65 10 73889 956 64423877
Full blood count abnormal 13.11 12.65 9 73890 29748 64395085
Medication error 13.04 12.65 100 73799 49866 64374967
Pyrexia 12.99 12.65 516 73383 558128 63866705
Ill-defined disorder 12.92 12.65 19 73880 44033 64380800
Refusal of treatment by patient 12.76 12.65 29 73870 8310 64416523
Unevaluable event 12.74 12.65 24 73875 50465 64374368
Cardiomyopathy acute 12.73 12.65 6 73893 236 64424597
Obsessive thoughts 12.66 12.65 10 73889 1007 64423826

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05AN01 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Lithium
CHEBI has role CHEBI:35477 antimanic drugs
MeSH PA D000928 Antidepressive Agents
MeSH PA D018692 Antimanic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Bipolar disorder indication 13746004 DOID:3312
Pain indication 22253000
Rheumatoid arthritis indication 69896004 DOID:7148
Bipolar disorder in remission indication 85248005
Bipolar affective disorder, current episode manic indication 191618007
Headache disorder indication 230461009
Dysmenorrhea indication 266599000
Fever indication 386661006
Osteoarthritis indication 396275006
Juvenile rheumatoid arthritis indication 410795001
Vascular headache off-label use 128187005
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Cluster Headache Prevention off-label use
Rapid Cycling Bipolar Affective Disorder off-label use
Psoriasis contraindication 9014002 DOID:8893
Diabetes insipidus contraindication 15771004 DOID:9409
Polyuria contraindication 28442001
Hypothyroidism contraindication 40930008 DOID:1459
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Acute infectious disease contraindication 63171007
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Organic mental disorder contraindication 111479008
Plaque psoriasis contraindication 200965009
Pregnancy, function contraindication 289908002
Breastfeeding (mother) contraindication 413712001
Severe dehydration contraindication 450316000
Lithium Toxicity contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glycogen synthase kinase-3 Kinase INHIBITOR CHEMBL CHEMBL
Inositol-1(or 4)-monophosphatase 1 Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
4018007 VUID
N0000146351 NUI
D00801 KEGG_DRUG
4018007 VANDF
4019803 VANDF
C0085217 UMLSCUI
CHEBI:6504 CHEBI
CHEBI:30145 CHEBI
CHEMBL1200826 ChEMBL_ID
D016651 MESH_DESCRIPTOR_UI
DB14509 DRUGBANK_ID
7439-93-2 SECONDARY_CAS_RN
2BMD2GNA4V UNII
11125 PUBCHEM_CID
3028194 PUBCHEM_CID
42351 RXNORM
1990 MMSL
4986 MMSL
d00061 MMSL
001532 NDDF
001533 NDDF
16977003 SNOMEDCT_US
321719003 SNOMEDCT_US
387095003 SNOMEDCT_US
85899009 SNOMEDCT_US
C0023870 UMLSCUI
CHEMBL2146126 ChEMBL_ID
D008094 MESH_DESCRIPTOR_UI
9FN79X2M3F UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0020 TABLET, EXTENDED RELEASE 450 mg ORAL ANDA 16 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0021 TABLET, EXTENDED RELEASE 300 mg ORAL ANDA 13 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-2526 CAPSULE, GELATIN COATED 150 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-2527 CAPSULE, GELATIN COATED 300 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-2531 CAPSULE, GELATIN COATED 600 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-4527 TABLET 300 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-8526 CAPSULE, GELATIN COATED 150 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-8527 CAPSULE, GELATIN COATED 300 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-8528 TABLET 300 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0054-8531 CAPSULE, GELATIN COATED 600 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0378-1300 TABLET, FILM COATED, EXTENDED RELEASE 300 mg ORAL ANDA 17 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0378-1450 TABLET, EXTENDED RELEASE 450 mg ORAL ANDA 15 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8302 CAPSULE 300 mg ORAL ANDA 26 sections
LITHIUM CARBONATE HUMAN PRESCRIPTION DRUG LABEL 1 16590-781 TABLET 300 mg ORAL NDA 2 sections
Lithium carbonate HUMAN PRESCRIPTION DRUG LABEL 1 23155-763 TABLET, FILM COATED, EXTENDED RELEASE 300 mg ORAL ANDA 15 sections
Lithium carbonate HUMAN PRESCRIPTION DRUG LABEL 1 23155-763 TABLET, FILM COATED, EXTENDED RELEASE 300 mg ORAL ANDA 15 sections
lithium carbonate HUMAN PRESCRIPTION DRUG LABEL 1 31722-544 CAPSULE 150 mg ORAL ANDA 25 sections
lithium carbonate HUMAN PRESCRIPTION DRUG LABEL 1 31722-545 CAPSULE 300 mg ORAL ANDA 25 sections
lithium carbonate HUMAN PRESCRIPTION DRUG LABEL 1 31722-546 CAPSULE 600 mg ORAL ANDA 25 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 33261-852 CAPSULE 300 mg ORAL ANDA 18 sections
Lithium CarbonateER HUMAN PRESCRIPTION DRUG LABEL 1 42291-496 TABLET 450 mg ORAL ANDA 20 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 43063-901 TABLET, EXTENDED RELEASE 450 mg ORAL ANDA 16 sections
Lithium Carbonate Human Prescription Drug Label 1 46708-148 TABLET, EXTENDED RELEASE 300 mg ORAL ANDA 16 sections
Lithium Carbonate Human Prescription Drug Label 1 46708-303 CAPSULE 150 mg ORAL ANDA 18 sections
Lithium Carbonate Human Prescription Drug Label 1 46708-304 CAPSULE 300 mg ORAL ANDA 18 sections
Lithium Carbonate Human Prescription Drug Label 1 46708-305 CAPSULE 600 mg ORAL ANDA 18 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 50090-1470 TABLET, FILM COATED, EXTENDED RELEASE 300 mg ORAL ANDA 17 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 50090-2754 TABLET, EXTENDED RELEASE 450 mg ORAL ANDA 16 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 50090-2799 CAPSULE, GELATIN COATED 300 mg ORAL NDA 26 sections
Lithium Carbonate HUMAN PRESCRIPTION DRUG LABEL 1 50090-2959 CAPSULE, GELATIN COATED 300 mg ORAL NDA 26 sections