All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

lithium carbonate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4207	554-13-2

Description:

Molecule	Description
Synonyms: lithium carbonate carbonic acid, dilithium salt dilithium carbonate	A lithium salt, classified as a mood-stabilizing agent. Lithium ion alters the metabolism of BIOGENIC MONOAMINES in the CENTRAL NERVOUS SYSTEM, and affects multiple neurotransmission systems. Molecular weight: 73.89 Formula: CLi2O3 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 63.19 ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
24	mmol	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	13 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	95 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	116.00 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

Date	Agency	Company	Orphan
April 6, 1970	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	1461.12	13.06	1368	50629	245882	63191143
Tremor	809.75	13.06	748	51249	131491	63305534
Antipsychotic drug level increased	799.42	13.06	233	51764	3202	63433823
Neuroleptic malignant syndrome	690.69	13.06	287	51710	11769	63425256
Nephrogenic diabetes insipidus	659.90	13.06	154	51843	805	63436220
Drug interaction	636.63	13.06	857	51140	228274	63208751
Mania	549.40	13.06	246	51751	12121	63424904
Extrapyramidal disorder	516.99	13.06	241	51756	13043	63423982
Sopor	362.48	13.06	226	51771	21938	63415087
Agitation	345.68	13.06	328	51669	59429	63377596
Drug abuse	343.56	13.06	357	51640	72161	63364864
Hypomania	320.22	13.06	138	51859	6192	63430833
Psychotic disorder	312.95	13.06	218	51779	25494	63411531
Antipsychotic drug level above therapeutic	306.94	13.06	85	51912	958	63436067
Ataxia	302.96	13.06	176	51821	15019	63422006
Hyperparathyroidism	293.14	13.06	103	51894	2646	63434379
Completed suicide	279.86	13.06	459	51538	145214	63291811
Confusional state	279.61	13.06	605	51392	235775	63201250
Suicidal ideation	273.76	13.06	295	51702	62126	63374899
Tardive dyskinesia	272.35	13.06	135	51862	8367	63428658
Sedation	263.33	13.06	233	51764	38576	63398449
Schizophrenia	260.74	13.06	138	51859	9814	63427211
Intentional self-injury	253.87	13.06	192	51805	25495	63411530
Pain	237.98	13.06	158	51839	740470	62696555
Suicide attempt	234.58	13.06	269	51728	60649	63376376
Overdose	228.24	13.06	368	51629	114710	63322315
Dysarthria	225.41	13.06	223	51774	42488	63394537
Parkinsonism	218.99	13.06	125	51872	10314	63426711
Bipolar disorder	218.84	13.06	114	51883	7846	63429179
Akathisia	212.19	13.06	117	51880	9029	63427996
Hypernatraemia	206.40	13.06	108	51889	7501	63429524
Muscle rigidity	197.47	13.06	121	51876	11379	63425646
Serotonin syndrome	196.14	13.06	173	51824	28509	63408516
Catatonia	185.92	13.06	85	51912	4392	63432633
Somnolence	183.85	13.06	433	51564	178252	63258773
Salivary hypersecretion	180.40	13.06	99	51898	7567	63429458
Aggression	179.48	13.06	151	51846	23347	63413678
Disorientation	179.16	13.06	190	51807	39262	63397763
Myoclonus	177.91	13.06	128	51869	15740	63421285
Arthralgia	172.85	13.06	129	51868	569581	62867444
Delusion	172.75	13.06	113	51884	11904	63425121
Diabetes insipidus	169.07	13.06	68	51929	2557	63434468
Pleurothotonus	164.97	13.06	56	51941	1293	63435732
Intentional overdose	163.42	13.06	249	51748	73903	63363122
Drug level increased	163.22	13.06	141	51856	22595	63414430
Infusion related reaction	158.46	13.06	11	51986	245510	63191515
Hallucination, auditory	154.29	13.06	108	51889	12716	63424309
Altered state of consciousness	152.51	13.06	142	51855	25088	63411937
Dyspnoea	149.60	13.06	194	51803	661119	62775906
Systemic lupus erythematosus	148.70	13.06	5	51992	208913	63228112
Rheumatoid arthritis	148.66	13.06	17	51980	253802	63183223
Polyuria	146.97	13.06	90	51907	8452	63428573
Disturbance in attention	140.86	13.06	165	51832	38024	63399001
Electrocardiogram QT prolonged	136.98	13.06	204	51793	59326	63377699
Arthropathy	136.81	13.06	16	51981	234776	63202249
Joint swelling	136.50	13.06	49	51948	327617	63109408
Swelling	135.38	13.06	30	51967	275348	63161677
Delirium	129.11	13.06	182	51815	50359	63386666
Contraindicated product administered	128.89	13.06	14	51983	217634	63219391
Glossodynia	128.29	13.06	4	51993	178872	63258153
Hypersensitivity	121.49	13.06	44	51953	292641	63144384
Alopecia	117.78	13.06	65	51932	337471	63099554
Restlessness	116.59	13.06	132	51865	29321	63407704
Nasopharyngitis	114.74	13.06	33	51964	254224	63182801
Abdominal discomfort	113.10	13.06	61	51936	320824	63116201
Mental status changes	112.29	13.06	150	51847	39449	63397576
Irritability	112.02	13.06	134	51863	31560	63405465
Abnormal behaviour	111.38	13.06	111	51886	21315	63415710
Polydipsia	106.50	13.06	54	51943	3510	63433515
Bradyphrenia	106.13	13.06	68	51929	6912	63430113
Jaundice cholestatic	105.58	13.06	69	51928	7255	63429770
Drug intolerance	105.42	13.06	61	51936	308600	63128425
Body tinea	104.96	13.06	44	51953	1841	63435184
Dyskinesia	102.90	13.06	129	51868	31873	63405152
Coma	101.41	13.06	186	51811	64178	63372847
Speech disorder	100.36	13.06	144	51853	40485	63396540
Sinusitis	99.38	13.06	31	51966	226622	63210403
Camptocormia	99.35	13.06	27	51970	282	63436743
Hypothyroidism	97.91	13.06	146	51851	42486	63394539
Obsessive-compulsive disorder	97.10	13.06	53	51944	4007	63433018
Inhibitory drug interaction	96.49	13.06	47	51950	2802	63434223
Neurotoxicity	93.86	13.06	91	51906	16899	63420126
Granulocytopenia	93.10	13.06	58	51939	5614	63431411
Depression	91.98	13.06	361	51636	196131	63240894
Peripheral swelling	91.59	13.06	52	51945	265890	63171135
Encephalopathy	91.19	13.06	134	51863	38486	63398539
Treatment failure	89.47	13.06	26	51971	199017	63238008
Psychomotor hyperactivity	88.66	13.06	72	51925	10591	63426434
Hyperreflexia	88.22	13.06	57	51940	5877	63431148
Fatigue	87.98	13.06	402	51595	887626	62549399
Depressed level of consciousness	86.18	13.06	170	51827	61908	63375117
Weight increased	85.63	13.06	431	51566	260361	63176664
Poisoning	84.51	13.06	78	51919	13622	63423403
Depressed mood	84.34	13.06	132	51865	40059	63396966
Mental disorder	82.56	13.06	104	51893	25815	63411210
Acute kidney injury	82.07	13.06	429	51568	262986	63174039
Pyramidal tract syndrome	81.69	13.06	24	51973	339	63436686
Glucose tolerance impaired	80.53	13.06	56	51941	6521	63430504
Dystonia	80.09	13.06	76	51921	13743	63423282
Hypercalcaemia	79.85	13.06	107	51890	28215	63408810
Pruritus	79.47	13.06	108	51889	361345	63075680
Infection susceptibility increased	78.81	13.06	44	51953	3477	63433548
Rash	78.69	13.06	219	51778	560652	62876373
Postural tremor	78.08	13.06	23	51974	328	63436697
Mutism	77.42	13.06	34	51963	1596	63435429
Stomatitis	77.03	13.06	11	51986	138714	63298311
Libido increased	73.57	13.06	31	51966	1314	63435711
Aphasia	71.50	13.06	110	51887	32890	63404135
Apathy	70.22	13.06	58	51939	8736	63428289
Cough	70.02	13.06	82	51915	292661	63144364
Infection	69.12	13.06	52	51945	229121	63207904
Blood prolactin increased	68.28	13.06	40	51957	3463	63433562
Bradykinesia	67.84	13.06	46	51951	5142	63431883
Antipsychotic drug level below therapeutic	67.72	13.06	20	51977	288	63436737
Electroencephalogram abnormal	66.53	13.06	40	51957	3632	63433393
Anaemia	66.17	13.06	86	51911	293344	63143681
Drug reaction with eosinophilia and systemic symptoms	65.33	13.06	107	51890	33729	63403296
Therapeutic product effect decreased	64.74	13.06	39	51958	193148	63243877
Back pain	64.23	13.06	73	51924	264072	63172953
Grandiosity	63.86	13.06	19	51978	281	63436744
Poor quality sleep	63.50	13.06	80	51917	19855	63417170
Logorrhoea	63.46	13.06	34	51963	2476	63434549
Disease progression	63.11	13.06	12	51985	122746	63314279
Treatment noncompliance	62.77	13.06	111	51886	37214	63399811
Cerebellar syndrome	62.70	13.06	38	51959	3501	63433524
Leukocytosis	62.69	13.06	91	51906	25844	63411181
Cogwheel rigidity	62.25	13.06	31	51966	1939	63435086
Nephropathy	61.74	13.06	47	51950	6294	63430731
Paranoia	61.61	13.06	61	51936	11618	63425407
Parathyroid tumour benign	60.86	13.06	23	51974	730	63436295
Pain in extremity	60.57	13.06	112	51885	331374	63105651
Psychiatric symptom	60.53	13.06	43	51954	5180	63431845
Brugada syndrome	59.05	13.06	19	51978	369	63436656
Stupor	58.52	13.06	39	51958	4236	63432789
Gestational diabetes	58.09	13.06	51	51946	8345	63428680
Impaired healing	57.23	13.06	8	51989	102534	63334491
Galactorrhoea	57.11	13.06	38	51959	4117	63432908
Tachyphrenia	56.77	13.06	26	51971	1348	63435677
Blister	56.42	13.06	18	51979	129796	63307229
Anxiety	55.57	13.06	336	51661	217205	63219820
Malignant neoplasm progression	54.97	13.06	3	51994	82118	63354907
Bipolar I disorder	54.50	13.06	28	51969	1871	63435154
Discomfort	54.40	13.06	35	51962	167339	63269686
Febrile neutropenia	54.07	13.06	15	51982	118434	63318591
Death	54.04	13.06	144	51853	374237	63062788
Anticholinergic syndrome	53.95	13.06	30	51967	2352	63434673
Product use issue	53.53	13.06	61	51936	220459	63216566
Intentional product use issue	53.38	13.06	19	51978	127873	63309152
Chronic kidney disease	53.23	13.06	116	51881	45282	63391743
Electrocardiogram T wave abnormal	53.19	13.06	30	51967	2417	63434608
Psychiatric decompensation	53.19	13.06	25	51972	1376	63435649
Cardio-respiratory arrest	52.74	13.06	137	51860	59822	63377203
Withdrawal syndrome	52.51	13.06	73	51924	19924	63417101
Persecutory delusion	52.13	13.06	31	51966	2759	63434266
Hostility	51.99	13.06	27	51970	1845	63435180
Resting tremor	51.90	13.06	21	51976	802	63436223
White blood cell count increased	51.25	13.06	119	51878	48442	63388583
Behaviour disorder	50.71	13.06	32	51965	3167	63433858
Euphoric mood	49.30	13.06	37	51960	4850	63432175
Blood creatine phosphokinase increased	49.25	13.06	89	51908	30341	63406684
Enuresis	49.15	13.06	29	51968	2544	63434481
Poisoning deliberate	49.09	13.06	53	51944	11165	63425860
Headache	49.00	13.06	311	51686	632930	62804095
Mental impairment	48.63	13.06	59	51938	14092	63422933
Hyperlipidaemia	47.78	13.06	69	51928	19502	63417523
Gastrointestinal disorder	47.57	13.06	24	51973	131215	63305810
Hypothermia	47.28	13.06	57	51940	13524	63423501
Urticaria	46.99	13.06	40	51957	165762	63271263
Cognitive disorder	46.52	13.06	125	51872	55690	63381335
Anger	46.21	13.06	54	51943	12402	63424623
Neutrophil count increased	45.91	13.06	62	51935	16465	63420560
Atrial fibrillation	45.90	13.06	19	51978	116617	63320408
Urinary retention	45.74	13.06	86	51911	30215	63406810
Personality disorder	45.72	13.06	38	51959	5773	63431252
Arthritis	45.43	13.06	19	51978	115902	63321123
Action tremor	45.21	13.06	15	51982	322	63436703
Schizoaffective disorder	45.19	13.06	31	51966	3531	63433494
Drooling	45.18	13.06	32	51965	3836	63433189
Psoriatic arthropathy	44.85	13.06	10	51987	91510	63345515
Sleep-related eating disorder	44.50	13.06	19	51978	832	63436193
Bundle branch block right	44.21	13.06	35	51962	4963	63432062
Hallucination, visual	44.17	13.06	66	51931	19232	63417793
Hallucination	43.92	13.06	121	51876	54696	63382329
Renal cyst	43.90	13.06	48	51949	10254	63426771
Substance abuse	43.25	13.06	34	51963	4773	63432252
Oculogyric crisis	42.64	13.06	23	51974	1698	63435327
Lower respiratory tract infection	42.53	13.06	28	51969	132279	63304746
Purpura	41.64	13.06	49	51948	11336	63425689
Abdominal pain upper	41.09	13.06	66	51931	206378	63230647
Psychomotor skills impaired	40.86	13.06	25	51972	2343	63434682
Soft tissue injury	40.71	13.06	22	51975	1630	63435395
Lethargy	40.37	13.06	119	51878	55888	63381137
Mobility decreased	39.82	13.06	25	51972	121134	63315891
Gastrointestinal haemorrhage	39.52	13.06	9	51988	81167	63355858
Fibromyalgia	38.98	13.06	9	51988	80411	63356614
Parkinsonian gait	38.88	13.06	15	51982	504	63436521
Diarrhoea	38.78	13.06	387	51610	714979	62722046
Impaired quality of life	38.73	13.06	52	51945	13731	63423294
Asterixis	38.34	13.06	20	51977	1379	63435646
Cholelithiasis	38.25	13.06	100	51897	43825	63393200
Hyperprolactinaemia	38.17	13.06	29	51968	3871	63433154
Hypertonia	37.89	13.06	31	51966	4606	63432419
International normalised ratio abnormal	37.82	13.06	27	51970	3277	63433748
Urinary incontinence	37.75	13.06	82	51915	31932	63405093
Goitre	36.88	13.06	34	51963	5927	63431098
Chest pain	36.77	13.06	76	51921	215883	63221142
Electrocardiogram T wave inversion	36.56	13.06	27	51970	3454	63433571
Sinus bradycardia	36.54	13.06	52	51945	14499	63422526
Protein C increased	36.41	13.06	10	51987	109	63436916
COVID-19	36.26	13.06	24	51973	113079	63323946
Impulsive behaviour	36.02	13.06	20	51977	1563	63435462
Thinking abnormal	35.96	13.06	44	51953	10599	63426426
Insomnia	35.93	13.06	300	51697	214952	63222073
Asthma	35.86	13.06	31	51966	127530	63309495
Visuospatial deficit	35.42	13.06	7	51990	13	63437012
Haemodialysis	35.23	13.06	40	51957	8907	63428118
Osteoarthritis	35.20	13.06	17	51980	95326	63341699
Choreoathetosis	35.09	13.06	14	51983	515	63436510
Cardiac failure congestive	34.87	13.06	16	51981	92417	63344608
Miosis	34.40	13.06	36	51961	7317	63429708
Bronchitis	34.35	13.06	31	51966	124904	63312121
Interstitial lung disease	34.14	13.06	5	51992	61903	63375122
Drug withdrawal syndrome	33.61	13.06	71	51926	27123	63409902
Post-traumatic neck syndrome	33.51	13.06	21	51976	2053	63434972
Hepatotoxicity	32.94	13.06	85	51912	36956	63400069
Impaired self-care	32.92	13.06	20	51977	1850	63435175
Blood sodium increased	32.84	13.06	23	51974	2709	63434316
Muscle twitching	32.43	13.06	58	51939	19610	63417415
Hypokinesia	32.37	13.06	48	51949	13888	63423137
Respiratory arrest	32.28	13.06	78	51919	32567	63404458
Rhabdomyolysis	32.26	13.06	94	51903	43857	63393168
Myocarditis	32.19	13.06	41	51956	10284	63426741
Drug hypersensitivity	32.15	13.06	138	51859	310549	63126476
Injection site erythema	32.00	13.06	14	51983	83160	63353865
Pneumonia	31.93	13.06	231	51766	456536	62980489
Sternal fracture	31.91	13.06	21	51976	2233	63434792
Blood bilirubin increased	31.77	13.06	84	51913	37056	63399969
Reflexes abnormal	31.68	13.06	14	51983	667	63436358
Mood swings	31.62	13.06	55	51942	18193	63418832
Renal oncocytoma	31.52	13.06	7	51990	28	63436997
Neuropathy peripheral	31.49	13.06	28	51969	113639	63323386
Hereditary ataxia	30.94	13.06	7	51990	31	63436994
Knee arthroplasty	30.78	13.06	4	51993	54202	63382823
Impaired work ability	30.71	13.06	53	51944	17422	63419603
Maternal exposure during pregnancy	30.69	13.06	86	51911	219976	63217049
Hyperthyroidism	30.50	13.06	48	51949	14625	63422400
Paraesthesia	30.46	13.06	51	51946	156915	63280110
Cerebellar atrophy	30.42	13.06	14	51983	734	63436291
Gait disturbance	30.40	13.06	255	51742	182923	63254102
Schizoaffective disorder bipolar type	30.26	13.06	9	51988	133	63436892
Clonus	29.77	13.06	27	51970	4609	63432416
Electrocardiogram abnormal	29.49	13.06	37	51960	9142	63427883
Papillary thyroid cancer	29.49	13.06	20	51977	2236	63434789
Musculoskeletal pain	29.02	13.06	20	51977	92257	63344768
Induced abortion failed	29.01	13.06	10	51987	242	63436783
Drug level above therapeutic	28.94	13.06	27	51970	4778	63432247
Hallucinations, mixed	28.82	13.06	27	51970	4802	63432223
Self-injurious ideation	28.77	13.06	21	51976	2638	63434387
Social avoidant behaviour	28.77	13.06	22	51975	2966	63434059
General physical health deterioration	28.60	13.06	78	51919	201324	63235701
Depressive symptom	28.54	13.06	25	51972	4077	63432948
Irritable bowel syndrome	28.49	13.06	16	51981	82396	63354629
Adams-Stokes syndrome	27.88	13.06	7	51990	52	63436973
Status epilepticus	27.83	13.06	47	51950	15186	63421839
Pressure of speech	27.70	13.06	13	51984	713	63436312
Mood altered	27.61	13.06	46	51951	14697	63422328
Acute psychosis	27.45	13.06	20	51977	2505	63434520
Dialysis	27.28	13.06	38	51959	10389	63426636
Eye movement disorder	27.01	13.06	27	51970	5201	63431824
Deprescribing error	26.82	13.06	6	51991	25	63437000
Differential white blood cell count abnormal	26.72	13.06	13	51984	773	63436252
Bone density decreased	26.58	13.06	45	51952	14567	63422458
Increased appetite	26.55	13.06	36	51961	9594	63427431
Nodal rhythm	26.54	13.06	17	51980	1726	63435299
Nystagmus	26.54	13.06	29	51968	6191	63430834
Abdominal pain	26.44	13.06	137	51860	293319	63143706
Injection site pruritus	26.43	13.06	3	51994	45113	63391912
Lung disorder	26.40	13.06	9	51988	62252	63374773
Ileus paralytic	26.31	13.06	25	51972	4526	63432499
Hypotonia	26.04	13.06	35	51962	9250	63427775
Hyperthermia malignant	25.98	13.06	13	51984	821	63436204
Persistent depressive disorder	25.92	13.06	14	51983	1036	63435989
Thrombocytopenia	25.88	13.06	53	51944	151104	63285921
Injection site swelling	25.87	13.06	4	51993	47568	63389457
Language disorder	25.53	13.06	18	51979	2142	63434883
Thyrotoxic crisis	25.38	13.06	13	51984	863	63436162
Ill-defined disorder	25.33	13.06	18	51979	81737	63355288
Affect lability	25.32	13.06	38	51959	11113	63425912
Major depression	25.25	13.06	32	51965	7986	63429039
Platelet count decreased	25.15	13.06	35	51962	116087	63320938
International normalised ratio increased	25.03	13.06	4	51993	46421	63390604
Myocarditis septic	25.00	13.06	6	51991	36	63436989
Cerebrovascular accident	24.99	13.06	31	51966	107993	63329032
Neonatal respiratory distress	24.64	13.06	10	51987	385	63436640
Off label use	24.49	13.06	397	51600	674065	62762960
Cerebral atrophy	24.05	13.06	25	51972	5041	63431984
Feeling guilty	24.01	13.06	11	51986	571	63436454
Nephropathy toxic	23.99	13.06	34	51963	9445	63427580
Ammonia increased	23.97	13.06	24	51973	4632	63432393
Conversion disorder	23.92	13.06	16	51981	1748	63435277
Muscle contractions involuntary	23.88	13.06	18	51979	2374	63434651
Electric shock sensation	23.72	13.06	12	51985	776	63436249
Hypotonia neonatal	23.69	13.06	14	51983	1232	63435793
Bruxism	23.56	13.06	21	51976	3504	63433521
Ideas of reference	23.56	13.06	7	51990	103	63436922
Toxic encephalopathy	23.54	13.06	28	51969	6551	63430474
Sepsis	23.51	13.06	57	51940	153066	63283959
Sluggishness	23.24	13.06	25	51972	5244	63431781
Antidepressant drug level increased	23.20	13.06	9	51988	307	63436718
Encopresis	23.08	13.06	7	51990	111	63436914
Histrionic personality disorder	22.88	13.06	6	51991	54	63436971
Poverty of speech	22.87	13.06	9	51988	319	63436706
Injection site pain	22.66	13.06	45	51952	129755	63307270
Skin disorder	22.51	13.06	64	51933	29443	63407582
Compulsive sexual behaviour	22.50	13.06	6	51991	58	63436967
Pleural effusion	22.36	13.06	26	51971	93184	63343841
Electroconvulsive therapy	22.22	13.06	6	51991	61	63436964
Nausea	21.95	13.06	533	51464	853938	62583087
Coordination abnormal	21.92	13.06	40	51957	13733	63423292
Oscillopsia	21.75	13.06	7	51990	136	63436889
Flat affect	21.73	13.06	14	51983	1436	63435589
Hyperammonaemia	21.64	13.06	24	51973	5208	63431817
Tachycardia	21.49	13.06	168	51829	117988	63319037
Mucosal inflammation	21.30	13.06	6	51991	46922	63390103
Anaphylactic reaction	21.22	13.06	14	51983	66086	63370939
Blunted affect	21.13	13.06	8	51989	255	63436770
Renal impairment	20.96	13.06	134	51863	88221	63348804
Long QT syndrome	20.86	13.06	19	51978	3260	63433765
Mydriasis	20.67	13.06	36	51961	11920	63425105
Merycism	20.62	13.06	8	51989	273	63436752
Seizure	20.61	13.06	182	51815	132452	63304573
Water intoxication	20.58	13.06	9	51988	418	63436607
Hyporeflexia	20.58	13.06	15	51982	1880	63435145
Liver injury	20.56	13.06	12	51985	60508	63376517
Borderline personality disorder	20.54	13.06	11	51986	800	63436225
Wheezing	20.51	13.06	29	51968	95566	63341459
Electrocardiogram repolarisation abnormality	20.44	13.06	13	51984	1304	63435721
Megacolon	20.44	13.06	15	51982	1900	63435125
Lactate pyruvate ratio increased	20.09	13.06	6	51991	90	63436935
Bone pain	19.78	13.06	10	51987	54631	63382394
Drug ineffective	19.71	13.06	680	51317	1044085	62392940
Disinhibition	19.67	13.06	11	51986	872	63436153
Rhinorrhoea	19.59	13.06	15	51982	65562	63371463
Productive cough	19.47	13.06	14	51983	63194	63373831
Drug level decreased	19.44	13.06	28	51969	7891	63429134
Delusion of reference	19.39	13.06	6	51991	102	63436923
Limbic encephalitis	19.35	13.06	8	51989	323	63436702
Homicidal ideation	19.33	13.06	14	51983	1738	63435287
Dysphoria	19.21	13.06	22	51975	4944	63432081
Hyperthermia	19.10	13.06	30	51967	9126	63427899
Irregular sleep wake rhythm disorder	19.08	13.06	7	51990	204	63436821
Unresponsive to stimuli	19.02	13.06	66	51931	33750	63403275
Refusal of treatment by patient	19.02	13.06	23	51974	5474	63431551
Cardiac arrest	18.76	13.06	135	51862	92410	63344615
Influenza	18.71	13.06	38	51959	108684	63328341
Agranulocytosis	18.68	13.06	54	51943	25080	63411945
Throat irritation	18.67	13.06	4	51993	37643	63399382
Skin ulcer	18.64	13.06	6	51991	43039	63393986
Inflammation	18.62	13.06	24	51973	82249	63354776
Affective disorder	18.52	13.06	24	51973	6122	63430903
Lipids decreased	18.43	13.06	4	51993	14	63437011
Arachnoid cyst	18.32	13.06	7	51990	229	63436796
Neuropsychiatric symptoms	18.23	13.06	10	51987	763	63436262
Psychomotor retardation	18.20	13.06	19	51978	3851	63433174
Balance disorder	18.19	13.06	125	51872	84297	63352728
Somatic symptom disorder	18.08	13.06	16	51981	2644	63434381
Urine osmolarity increased	18.03	13.06	6	51991	130	63436895
Bradycardia	17.96	13.06	112	51885	73115	63363910
Staring	17.93	13.06	13	51984	1617	63435408
Blood citric acid increased	17.84	13.06	5	51992	59	63436966
Dyspnoea exertional	17.75	13.06	14	51983	60288	63376737
Acquired cystic kidney disease	17.69	13.06	5	51992	61	63436964
Negativism	17.57	13.06	8	51989	409	63436616
Essential tremor	17.54	13.06	11	51986	1077	63435948
Hallucination, olfactory	17.53	13.06	7	51990	258	63436767
Medication error	17.51	13.06	87	51910	52197	63384828
Alcohol interaction	17.40	13.06	15	51982	2394	63434631
Psychotic disorder due to a general medical condition	17.26	13.06	7	51990	269	63436756
Cardiac failure	17.25	13.06	29	51968	89113	63347912
Antidepressant drug level above therapeutic	17.21	13.06	8	51989	429	63436596
Ear infection	17.13	13.06	5	51992	38208	63398817
Stereotypy	17.13	13.06	8	51989	434	63436591
Distractibility	17.09	13.06	8	51989	436	63436589
Blood urea increased	17.08	13.06	54	51943	26325	63410700
Joint range of motion decreased	17.02	13.06	3	51994	32425	63404600
Muscle spasms	16.97	13.06	68	51929	156082	63280943
Pneumonitis	16.95	13.06	4	51993	35218	63401807
Epileptic encephalopathy	16.76	13.06	7	51990	290	63436735
Loss of personal independence in daily activities	16.74	13.06	34	51963	97256	63339769
Clear cell renal cell carcinoma	16.69	13.06	12	51985	1473	63435552
Upper respiratory tract infection	16.53	13.06	26	51971	82021	63355004
Retroperitoneal fibrosis	16.49	13.06	7	51990	302	63436723
Colectomy total	16.42	13.06	6	51991	173	63436852
Slow speech	16.37	13.06	12	51985	1517	63435508
Potentiating drug interaction	16.35	13.06	19	51978	4337	63432688
Haematochezia	16.31	13.06	12	51985	53532	63383493
Acalculia	16.25	13.06	3	51994	3	63437022
Neutrophilia	16.17	13.06	19	51978	4387	63432638
Compartment syndrome	16.05	13.06	14	51983	2270	63434755
Osteoporosis	16.03	13.06	14	51983	57324	63379701
Blood pressure fluctuation	15.99	13.06	9	51988	46308	63390717
Cystitis	15.89	13.06	13	51984	54978	63382047
Food craving	15.85	13.06	12	51985	1594	63435431
Tonsillar hypertrophy	15.83	13.06	10	51987	991	63436034
Haemorrhage	15.76	13.06	16	51981	61006	63376019
Pain in jaw	15.68	13.06	8	51989	43488	63393537
Antipsychotic drug level decreased	15.60	13.06	7	51990	346	63436679
Foetal malnutrition	15.59	13.06	5	51992	96	63436929
Slow response to stimuli	15.55	13.06	10	51987	1022	63436003
Plasma cell myeloma	15.55	13.06	5	51992	35900	63401125
Hypoaesthesia	15.49	13.06	78	51919	168315	63268710
Ileus	15.44	13.06	36	51961	14689	63422336
Ascites	15.43	13.06	7	51990	40721	63396304
Breast engorgement	15.35	13.06	5	51992	101	63436924
Malaise	15.32	13.06	244	51753	415710	63021315
Blood pressure systolic increased	15.26	13.06	10	51987	47387	63389638
Hyperhidrosis	15.24	13.06	145	51852	107691	63329334
Blood cholesterol increased	15.23	13.06	34	51963	93998	63343027
Decreased appetite	15.16	13.06	132	51865	250920	63186105
Thyroiditis	15.13	13.06	14	51983	2452	63434573
Urine output increased	15.07	13.06	11	51986	1382	63435643
Neurological symptom	15.01	13.06	21	51976	5762	63431263
Joint injury	14.96	13.06	3	51994	29569	63407456
Echolalia	14.96	13.06	6	51991	224	63436801
Gaze palsy	14.88	13.06	11	51986	1409	63435616
Atrial septal defect	14.84	13.06	23	51974	6915	63430110
Movement disorder	14.64	13.06	45	51952	21616	63415409
Sexually inappropriate behaviour	14.51	13.06	5	51992	121	63436904
Sciatica	14.48	13.06	5	51992	34319	63402706
Distal intestinal obstruction syndrome	14.47	13.06	7	51990	411	63436614
Delusional perception	14.45	13.06	6	51991	245	63436780
Drug eruption	14.44	13.06	54	51943	28640	63408385
Injection site reaction	14.39	13.06	16	51981	58508	63378517
Glomerulonephritis minimal lesion	14.36	13.06	6	51991	249	63436776
Stevens-Johnson syndrome	14.30	13.06	49	51948	24901	63412124
Cerebellar ataxia	14.24	13.06	9	51988	893	63436132
Cardiomyopathy acute	14.18	13.06	6	51991	257	63436768
Thought insertion	14.17	13.06	3	51994	9	63437016
Dysphemia	14.16	13.06	14	51983	2661	63434364
Memory impairment	14.15	13.06	139	51858	104119	63332906
Incoherent	14.14	13.06	18	51979	4512	63432513
Polyhydramnios	14.14	13.06	13	51984	2258	63434767
Oral herpes	13.90	13.06	50	51947	26024	63411001
Muscle tone disorder	13.85	13.06	5	51992	139	63436886
Gambling disorder	13.80	13.06	10	51987	1242	63435783
Amimia	13.71	13.06	4	51993	55	63436970
Unmasking of previously unidentified disease	13.59	13.06	9	51988	967	63436058
Decreased activity	13.59	13.06	21	51976	6299	63430726
Amenorrhoea	13.57	13.06	27	51970	9887	63427138
Melaena	13.56	13.06	4	51993	30361	63406664
Night sweats	13.55	13.06	12	51985	48802	63388223
Tooth injury	13.52	13.06	10	51987	1282	63435743
Congenital aqueductal stenosis	13.51	13.06	3	51994	12	63437013
Dry skin	13.50	13.06	16	51981	56871	63380154
Localised infection	13.46	13.06	4	51993	30206	63406819
Nocturia	13.41	13.06	24	51973	8117	63428908
Abulia	13.37	13.06	7	51990	486	63436539
Osteonecrosis of jaw	13.37	13.06	6	51991	35117	63401908
Sinus tachycardia	13.33	13.06	47	51950	24221	63412804
Hypoxic-ischaemic encephalopathy	13.33	13.06	17	51980	4270	63432755
Progressive supranuclear palsy	13.27	13.06	4	51993	62	63436963
Radial nerve palsy	13.23	13.06	7	51990	497	63436528
Brain injury	13.22	13.06	22	51975	7021	63430004
Thought blocking	13.22	13.06	5	51992	159	63436866
Femur fracture	13.19	13.06	9	51988	41747	63395278
Haematoma	13.17	13.06	6	51991	34814	63402211
Divorced	13.13	13.06	3	51994	14	63437011
Nightmare	13.08	13.06	40	51957	19154	63417871

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	886.18	13.80	1111	38677	199251	34717892
Neuroleptic malignant syndrome	598.85	13.80	326	39462	17608	34899535
Antipsychotic drug level increased	572.09	13.80	201	39587	3664	34913479
Tremor	536.14	13.80	560	39228	82027	34835116
Mania	496.63	13.80	234	39554	9277	34907866
Nephrogenic diabetes insipidus	398.49	13.80	118	39670	1203	34915940
Akathisia	370.25	13.80	182	39606	7927	34909216
Suicide attempt	354.65	13.80	319	39469	38797	34878346
Obsessive-compulsive disorder	331.32	13.80	150	39638	5414	34911729
Antipsychotic drug level below therapeutic	311.32	13.80	115	39673	2432	34914711
Extrapyramidal disorder	276.41	13.80	176	39612	12704	34904439
Parkinsonism	252.39	13.80	141	39647	7997	34909146
Drug interaction	235.74	13.80	675	39113	225271	34691872
Disinhibition	230.94	13.80	99	39689	3127	34914016
Euphoric mood	220.51	13.80	114	39674	5527	34911616
Serotonin syndrome	211.66	13.80	178	39610	19755	34897388
Therapeutic product effect variable	211.55	13.80	86	39702	2370	34914773
Increased appetite	199.00	13.80	117	39671	7312	34909831
Antipsychotic drug level above therapeutic	189.61	13.80	66	39722	1167	34915976
Psychotic disorder	184.15	13.80	180	39608	24272	34892871
Dysarthria	170.40	13.80	204	39584	34578	34882565
Psychomotor hyperactivity	166.50	13.80	115	39673	9507	34907636
Suicidal ideation	166.10	13.80	217	39571	40171	34876972
Agitation	162.16	13.80	258	39530	57141	34860002
Weight increased	158.54	13.80	336	39452	92697	34824446
Granulocytopenia	151.56	13.80	94	39694	6473	34910670
Hypomania	148.07	13.80	66	39722	2293	34914850
Sedation	144.08	13.80	147	39641	20859	34896284
Confusional state	142.51	13.80	423	39365	143737	34773406
Irritability	141.41	13.80	157	39631	24533	34892610
Diabetes insipidus	140.46	13.80	68	39720	2860	34914283
Aggression	136.93	13.80	194	39594	38770	34878373
Febrile neutropenia	124.29	13.80	8	39780	136841	34780302
Ataxia	123.47	13.80	112	39676	13741	34903402
Dyspnoea	122.27	13.80	150	39638	376632	34540511
Dyskinesia	120.64	13.80	138	39650	22275	34894868
Schizophrenia	118.93	13.80	90	39698	8576	34908567
Salivary hypersecretion	112.54	13.80	87	39701	8557	34908586
Bipolar disorder	109.48	13.80	62	39726	3607	34913536
Leukopenia	108.12	13.80	228	39560	62628	34854515
Delusion	104.54	13.80	98	39690	12537	34904606
Hallucination, auditory	103.56	13.80	95	39693	11822	34905321
Completed suicide	100.65	13.80	292	39496	97876	34819267
Death	99.71	13.80	189	39599	397860	34519283
Myoclonus	99.06	13.80	102	39686	14623	34902520
Tardive dyskinesia	97.35	13.80	68	39720	5722	34911421
Arthralgia	95.63	13.80	37	39751	170004	34747139
Hypernatraemia	92.53	13.80	77	39711	8413	34908730
Muscle rigidity	89.75	13.80	83	39705	10435	34906708
Schizoaffective disorder	89.33	13.80	39	39749	1288	34915855
Overdose	88.69	13.80	266	39522	90793	34826350
Bruxism	85.35	13.80	41	39747	1694	34915449
Anaemia	84.16	13.80	85	39703	233250	34683893
White blood cell count increased	83.56	13.80	160	39628	40991	34876152
Hyperparathyroidism	82.48	13.80	36	39752	1188	34915955
Priapism	82.44	13.80	58	39730	4936	34912207
Cough	82.23	13.80	34	39754	150106	34767037
Catatonia	82.12	13.80	58	39730	4967	34912176
Dyslipidaemia	81.79	13.80	68	39720	7420	34909723
Disease progression	78.74	13.80	14	39774	108063	34809080
Somnolence	76.64	13.80	289	39499	110827	34806316
Sopor	76.15	13.80	81	39707	12055	34905088
Delirium	76.10	13.80	160	39628	43831	34873312
Intentional overdose	75.73	13.80	159	39629	43515	34873628
Oppositional defiant disorder	75.32	13.80	27	39761	522	34916621
Coordination abnormal	72.45	13.80	64	39724	7580	34909563
Pain	71.02	13.80	77	39711	204598	34712545
Obesity	70.48	13.80	80	39708	12798	34904345
Decreased eye contact	70.39	13.80	25	39763	470	34916673
Abnormal behaviour	70.11	13.80	112	39676	24857	34892286
Malignant neoplasm progression	67.27	13.80	10	39778	88036	34829107
Neutrophil count increased	67.15	13.80	90	39698	17056	34900087
Pain in extremity	67.10	13.80	30	39758	126483	34790660
Prescribed overdose	66.69	13.80	71	39717	10576	34906567
Mental status changes	66.43	13.80	139	39649	37944	34879199
Homicidal ideation	65.99	13.80	40	39748	2642	34914501
Pneumonia	65.54	13.80	204	39584	362423	34554720
Coma	63.19	13.80	152	39636	45526	34871617
Blood creatine phosphokinase increased	61.76	13.80	149	39639	44708	34872435
Leukaemia	59.19	13.80	46	39742	4557	34912586
Hyperreflexia	57.06	13.80	39	39749	3167	34913976
Polydipsia	56.70	13.80	42	39746	3873	34913270
Cognitive disorder	56.32	13.80	110	39678	28583	34888560
Treatment noncompliance	55.48	13.80	108	39680	27992	34889151
Dystonia	55.36	13.80	65	39723	10780	34906363
Depressed level of consciousness	54.43	13.80	138	39650	42703	34874440
Back pain	54.22	13.80	36	39752	121753	34795390
Restlessness	54.09	13.80	101	39687	25381	34891762
Pancytopenia	52.95	13.80	21	39767	95136	34822007
Speech disorder	52.28	13.80	100	39688	25586	34891557
Affect lability	52.19	13.80	39	39749	3644	34913499
Brugada syndrome	52.16	13.80	23	39765	778	34916365
Atrial fibrillation	52.07	13.80	38	39750	122355	34794788
Disorientation	52.00	13.80	116	39672	33072	34884071
Pruritus	51.94	13.80	51	39737	141930	34775213
Fatigue	51.00	13.80	233	39555	370420	34546723
Interstitial lung disease	50.83	13.80	7	39781	65275	34851868
Peripheral swelling	49.46	13.80	13	39775	76528	34840615
Hypothyroidism	48.35	13.80	86	39702	20816	34896327
Neurotoxicity	48.12	13.80	79	39709	17931	34899212
Anxiety	47.89	13.80	232	39556	99196	34817947
Thinking abnormal	47.71	13.80	46	39742	6091	34911052
Oedema peripheral	47.43	13.80	40	39748	119772	34797371
Disturbance in attention	46.76	13.80	96	39692	25849	34891294
Dystonic tremor	46.71	13.80	15	39773	204	34916939
Myocarditis	44.92	13.80	66	39722	13616	34903527
General physical health deterioration	44.72	13.80	48	39740	128221	34788922
Sepsis	43.36	13.80	77	39711	166484	34750659
Clonus	43.22	13.80	31	39757	2719	34914424
Intentional self-injury	43.16	13.80	65	39723	13706	34903437
Thrombocytopenia	42.72	13.80	70	39718	156177	34760966
Rash	42.51	13.80	122	39666	222630	34694513
Electrocardiogram QRS complex prolonged	42.48	13.80	39	39749	4855	34912288
Paranoia	42.22	13.80	60	39728	12008	34905135
Abulia	41.58	13.80	18	39770	582	34916561
Gastrointestinal haemorrhage	40.94	13.80	25	39763	88452	34828691
Depression	40.76	13.80	218	39570	96880	34820263
Cardiac failure congestive	40.71	13.80	22	39766	83248	34833895
Hyperthermia	40.62	13.80	55	39733	10522	34906621
Infusion related reaction	40.57	13.80	6	39782	53051	34864092
Choreoathetosis	40.13	13.80	21	39767	1043	34916100
Tachycardia foetal	40.12	13.80	15	39773	328	34916815
Cerebellar syndrome	40.03	13.80	28	39760	2360	34914783
Failure to suspend medication	40	13.80	16	39772	422	34916721
Logorrhoea	39.63	13.80	28	39760	2398	34914745
Therapeutic product effect incomplete	39.49	13.80	137	39651	50404	34866739
Insomnia	38.77	13.80	226	39562	103681	34813462
Electrocardiogram QT prolonged	38.28	13.80	118	39670	40834	34876309
Blood thyroid stimulating hormone decreased	37.87	13.80	25	39763	1916	34915227
Apathy	37.82	13.80	43	39745	6889	34910254
Hyperparathyroidism primary	37.59	13.80	12	39776	160	34916983
Myocardial infarction	37.22	13.80	50	39738	121035	34796108
Leukocytosis	36.45	13.80	83	39705	23982	34893161
Delusion of grandeur	35.68	13.80	20	39768	1140	34916003
Joint swelling	35.36	13.80	12	39776	59878	34857265
Drug level above therapeutic	35.14	13.80	33	39755	4228	34912915
Nephropathy	34.50	13.80	38	39750	5879	34911264
Diarrhoea	33.80	13.80	283	39505	389629	34527514
Septic shock	33.65	13.80	20	39768	71814	34845329
Grandiosity	33.53	13.80	13	39775	315	34916828
Enuresis	33.53	13.80	25	39763	2328	34914815
Balance disorder	33.33	13.80	112	39676	40542	34876601
Tachycardia	33.33	13.80	187	39601	84585	34832558
Drug level increased	33.23	13.80	76	39712	22020	34895123
Anger	32.93	13.80	53	39735	11831	34905312
Mental impairment	32.74	13.80	49	39739	10273	34906870
Hyperkinesia	32.64	13.80	22	39766	1746	34915397
Affective disorder	32.61	13.80	32	39756	4328	34912815
Antipsychotic drug level decreased	32.55	13.80	18	39770	999	34916144
Rheumatoid arthritis	32.52	13.80	3	39785	38235	34878908
Abdominal pain	32.38	13.80	88	39700	163530	34753613
Trismus	32.22	13.80	25	39763	2470	34914673
Hyperprolactinaemia	32.22	13.80	21	39767	1575	34915568
Intentional product use issue	31.98	13.80	14	39774	59802	34857341
Distractibility	31.88	13.80	13	39775	361	34916782
Pressure of speech	31.55	13.80	14	39774	481	34916662
Bipolar I disorder	31.02	13.80	16	39772	771	34916372
Patient restraint	30.90	13.80	9	39779	86	34917057
Polyuria	30.54	13.80	43	39745	8531	34908612
Blood prolactin increased	30.35	13.80	21	39767	1739	34915404
Apraxia	30.22	13.80	19	39769	1339	34915804
Thrombosis	29.98	13.80	10	39778	50448	34866695
Melaena	29.50	13.80	3	39785	35377	34881766
Mental disorder	29.46	13.80	58	39730	15151	34901992
Sexual dysfunction	29.25	13.80	36	39752	6267	34910876
Prostate cancer	29.15	13.80	5	39783	39644	34877499
Epistaxis	29.04	13.80	15	39773	58236	34858907
Metabolic syndrome	28.66	13.80	20	39768	1679	34915464
Psychiatric decompensation	28.65	13.80	25	39763	2912	34914231
Restless legs syndrome	28.44	13.80	41	39747	8313	34908830
Bradyphrenia	28.30	13.80	31	39757	4767	34912376
Mucosal inflammation	28.11	13.80	5	39783	38617	34878526
Coronary artery disease	27.96	13.80	10	39778	48295	34868848
Sexually inappropriate behaviour	27.95	13.80	13	39775	499	34916644
Decreased appetite	27.59	13.80	97	39691	166295	34750848
Headache	27.57	13.80	126	39662	200509	34716634
Lethargy	27.50	13.80	106	39682	41016	34876127
Infection	27.47	13.80	38	39750	90877	34826266
Feelings of worthlessness	26.89	13.80	11	39777	308	34916835
Haemoptysis	26.67	13.80	4	39784	35002	34882141
Acute myocardial infarction	26.53	13.80	14	39774	53705	34863438
Depressed mood	26.39	13.80	64	39724	19253	34897890
Blood thyroid stimulating hormone increased	25.98	13.80	28	39760	4227	34912916
Neuropathy peripheral	25.96	13.80	34	39754	83229	34833914
Pleural effusion	25.74	13.80	33	39755	81513	34835630
Drooling	25.63	13.80	25	39763	3357	34913786
Blunted affect	25.60	13.80	11	39777	349	34916794
Plasma cell myeloma	25.56	13.80	8	39780	42029	34875114
Cogwheel rigidity	25.38	13.80	17	39771	1335	34915808
Blood sodium increased	25.31	13.80	23	39765	2825	34914318
Productive cough	25.23	13.80	6	39782	37807	34879336
Flight of ideas	25.11	13.80	11	39777	366	34916777
Muscle spasms	25.10	13.80	29	39759	74972	34842171
Crying	24.85	13.80	32	39756	5830	34911313
Cardiac failure	24.80	13.80	41	39747	91207	34825936
Poisoning deliberate	24.54	13.80	37	39751	7807	34909336
Eosinophil count decreased	24.54	13.80	17	39771	1411	34915732
Otospondylomegaepiphyseal dysplasia	24.44	13.80	8	39780	116	34917027
Off label use	24.38	13.80	334	39454	419190	34497953
Electroconvulsive therapy	24.13	13.80	6	39782	29	34917114
Cerebrovascular accident	24.10	13.80	37	39751	84774	34832369
Metabolic encephalopathy	24.05	13.80	27	39761	4265	34912878
Blood triglycerides increased	23.88	13.80	51	39737	14108	34903035
Musculoskeletal pain	23.56	13.80	4	39784	31959	34885184
Non-high-density lipoprotein cholesterol increased	23.38	13.80	8	39780	134	34917009
Pneumonitis	23.36	13.80	5	39783	33873	34883270
Haemorrhage	23.09	13.80	15	39773	51355	34865788
Hypotonia neonatal	23.08	13.80	16	39772	1329	34915814
Arthritis	22.94	13.80	4	39784	31342	34885801
Angioedema	22.92	13.80	7	39781	37367	34879776
Encephalopathy	22.77	13.80	90	39698	35229	34881914
Altered state of consciousness	22.35	13.80	67	39721	22826	34894317
Self-injurious ideation	22.02	13.80	17	39771	1667	34915476
Anaphylactic reaction	21.80	13.80	5	39783	32296	34884847
Dyspnoea exertional	21.79	13.80	11	39777	43268	34873875
Abdominal distension	21.37	13.80	21	39767	58471	34858672
Erythema	21.35	13.80	43	39745	88737	34828406
Urticaria	21.00	13.80	24	39764	62353	34854790
COVID-19	20.93	13.80	35	39753	77515	34839628
Agranulocytosis	20.75	13.80	67	39721	23754	34893389
Floppy infant	20.64	13.80	7	39781	114	34917029
Sleep disorder	20.63	13.80	81	39707	31607	34885536
Cerebral haemorrhage	20.62	13.80	7	39781	34930	34882213
Chest discomfort	20.60	13.80	19	39769	54511	34862632
Hepatic failure	20.24	13.80	7	39781	34524	34882619
Drug hypersensitivity	20.24	13.80	38	39750	80491	34836652
Diabetes mellitus	20.16	13.80	106	39682	46767	34870376
Urinary incontinence	20.12	13.80	57	39731	18817	34898326
Weight decreased	20.10	13.80	118	39670	176183	34740960
Gambling disorder	20.07	13.80	16	39772	1644	34915499
Hypersensitivity	19.99	13.80	24	39764	61011	34856132
High-grade B-cell lymphoma	19.89	13.80	7	39781	128	34917015
Persistent depressive disorder	19.68	13.80	9	39779	332	34916811
Mood altered	19.64	13.80	36	39752	8916	34908227
Left atrial dilatation	19.49	13.80	17	39771	1979	34915164
Major depression	19.45	13.80	25	39763	4547	34912596
Stupor	19.39	13.80	20	39768	2871	34914272
Psychotic symptom	19.39	13.80	16	39772	1727	34915416
Gait disturbance	19.25	13.80	164	39624	84976	34832167
Upper gastrointestinal haemorrhage	19.24	13.80	3	39785	25515	34891628
Renal cyst	19.23	13.80	36	39752	9057	34908086
Antipsychotic drug level	19.08	13.80	4	39784	7	34917136
Oncocytoma	19.08	13.80	4	39784	7	34917136
Wrong patient received product	18.96	13.80	19	39769	2635	34914508
Bone marrow failure	18.83	13.80	5	39783	29248	34887895
Speech sound disorder	18.68	13.80	7	39781	154	34916989
Staphylococcal infection	18.59	13.80	7	39781	32753	34884390
Convulsive threshold lowered	18.54	13.80	10	39778	528	34916615
Dysphemia	18.49	13.80	15	39773	1580	34915563
Herpes zoster	18.46	13.80	8	39780	34391	34882752
Impulsive behaviour	18.32	13.80	17	39771	2145	34914998
Movement disorder	18.27	13.80	42	39746	12206	34904937
Eosinophil count increased	18.21	13.80	34	39754	8538	34908605
Neutrophilia	18.19	13.80	23	39765	4114	34913029
Nephrolithiasis	18.04	13.80	6	39782	30327	34886816
Poor quality sleep	17.86	13.80	33	39755	8223	34908920
Autonomic nervous system imbalance	17.75	13.80	18	39770	2533	34914610
Secondary tic	17.59	13.80	4	39784	12	34917131
Differential white blood cell count abnormal	17.51	13.80	14	39774	1445	34915698
Syncope	17.47	13.80	50	39738	91401	34825742
Kidney enlargement	17.42	13.80	11	39777	781	34916362
Wheezing	17.40	13.80	13	39775	41389	34875754
Hypokinesia	17.36	13.80	34	39754	8846	34908297
Angina pectoris	17.30	13.80	7	39781	31356	34885787
Memory impairment	17.30	13.80	96	39692	43222	34873921
Hypoaesthesia	17.26	13.80	27	39761	61417	34855726
Haematoma	17.21	13.80	4	39784	25601	34891542
Chest pain	17.15	13.80	80	39708	126682	34790461
Product dose omission issue	17.13	13.80	74	39714	119637	34797506
Cerebral infarction	17.10	13.80	5	39783	27450	34889693
Stomatitis	17.04	13.80	14	39774	42500	34874643
Hallucination, olfactory	17.01	13.80	7	39781	199	34916944
Neoplasm progression	16.99	13.80	3	39785	23297	34893846
Foetal exposure during pregnancy	16.96	13.80	87	39701	38014	34879129
Polydipsia psychogenic	16.78	13.80	6	39782	115	34917028
Echocardiogram abnormal	16.74	13.80	12	39776	1051	34916092
Withdrawal syndrome	16.73	13.80	41	39747	12414	34904729
Libido increased	16.70	13.80	11	39777	840	34916303
Ascites	16.69	13.80	17	39771	46554	34870589
Thyroxine decreased	16.60	13.80	7	39781	212	34916931
Tri-iodothyronine decreased	16.55	13.80	6	39782	120	34917023
Hydrops foetalis	16.51	13.80	11	39777	856	34916287
Accidental death	16.49	13.80	17	39771	2439	34914704
Oromandibular dystonia	16.40	13.80	9	39779	492	34916651
Social anxiety disorder	16.40	13.80	8	39780	342	34916801
Hypertonia	16.18	13.80	22	39766	4224	34912919
International normalised ratio increased	16.15	13.80	18	39770	47309	34869834
Haematuria	16.06	13.80	20	39768	50046	34867097
Inappropriate affect	16.06	13.80	10	39778	693	34916450
Depressive symptom	16.05	13.80	18	39770	2841	34914302
Hallucination	16.04	13.80	107	39681	51391	34865752
Multiple organ dysfunction syndrome	16.03	13.80	40	39748	76526	34840617
Thought blocking	15.97	13.80	6	39782	133	34917010
Diabetic coma	15.95	13.80	11	39777	906	34916237
Platelet count decreased	15.94	13.80	76	39712	119641	34797502
Cerebral amyloid angiopathy	15.85	13.80	6	39782	136	34917007
Gastrooesophageal reflux disease	15.82	13.80	12	39776	37912	34879231
Oxygen saturation decreased	15.74	13.80	23	39765	53795	34863348
Dry skin	15.68	13.80	8	39780	31279	34885864
Dysphoria	15.57	13.80	16	39772	2286	34914857
Gastrectomy	15.45	13.80	6	39782	146	34916997
Globulins increased	15.39	13.80	8	39780	392	34916751
Toxic encephalopathy	15.35	13.80	24	39764	5225	34911918
Myalgia	15.33	13.80	47	39741	84063	34833080
Atrioventricular block first degree	15.30	13.80	26	39762	6066	34911077
Toxic cardiomyopathy	15.26	13.80	7	39781	260	34916883
Lymphocyte count increased	15.26	13.80	19	39769	3346	34913797
Chronic obstructive pulmonary disease	15.22	13.80	20	39768	48898	34868245
Hypersexuality	15.15	13.80	13	39775	1480	34915663
Muscle twitching	15.02	13.80	35	39753	10263	34906880
Acarodermatitis	15.00	13.80	8	39780	413	34916730
Metastases to eye	15.00	13.80	5	39783	77	34917066
Sinusitis	14.97	13.80	15	39773	41387	34875756
Weight	14.96	13.80	4	39784	27	34917116
Arthropathy	14.85	13.80	6	39782	26901	34890242
Intention tremor	14.79	13.80	8	39780	425	34916718
Long QT syndrome	14.64	13.80	17	39771	2786	34914357
Muscle contractions involuntary	14.59	13.80	14	39774	1842	34915301
Bradykinesia	14.58	13.80	20	39768	3873	34913270
Abdominal pain upper	14.46	13.80	38	39750	71452	34845691
Lung disorder	14.44	13.80	11	39777	34685	34882458
Cardiomyopathy	14.39	13.80	47	39741	16761	34900382
Nausea	14.30	13.80	287	39501	339621	34577522
Bronchitis	14.28	13.80	16	39772	41947	34875196
Psychomotor retardation	14.04	13.80	19	39769	3631	34913512
Hypothermia	14.03	13.80	35	39753	10713	34906430
Dysphagia	14.01	13.80	120	39668	62261	34854882
Feeling guilty	13.99	13.80	7	39781	316	34916827
Drug withdrawal syndrome	13.98	13.80	52	39736	19782	34897361
Hypoxia	13.84	13.80	26	39762	55069	34862074

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	2048.04	13.20	2267	75056	419273	79247792
Tremor	1270.28	13.20	1158	76165	168925	79498140
Antipsychotic drug level increased	1268.01	13.20	392	76931	5565	79661500
Neuroleptic malignant syndrome	1169.29	13.20	559	76764	27000	79640065
Nephrogenic diabetes insipidus	955.84	13.20	251	77072	1883	79665182
Mania	806.82	13.20	381	76942	17879	79649186
Drug interaction	798.47	13.20	1435	75888	413748	79253317
Extrapyramidal disorder	760.10	13.20	392	76931	22287	79644778
Agitation	466.24	13.20	528	76795	99187	79567878
Antipsychotic drug level above therapeutic	460.00	13.20	141	77182	1939	79665126
Hypomania	446.18	13.20	193	77130	7351	79659714
Ataxia	444.11	13.20	286	77037	24753	79642312
Psychotic disorder	412.21	13.20	333	76990	41069	79625996
Suicide attempt	411.42	13.20	453	76870	82479	79584586
Sopor	408.30	13.20	302	77021	32708	79634357
Parkinsonism	403.62	13.20	232	77091	16352	79650713
Confusional state	398.69	13.20	922	76401	317075	79349990
Serotonin syndrome	397.98	13.20	338	76985	44689	79622376
Hyperparathyroidism	384.13	13.20	137	77186	3087	79663978
Akathisia	373.01	13.20	204	77119	13055	79654010
Suicidal ideation	364.88	13.20	409	76914	75931	79591134
Dysarthria	364.51	13.20	386	76937	67236	79599829
Completed suicide	353.37	13.20	753	76570	245014	79422051
Schizophrenia	338.83	13.20	202	77121	15238	79651827
Sedation	319.07	13.20	318	77005	51577	79615488
Tardive dyskinesia	287.31	13.20	159	77164	10412	79656653
Salivary hypersecretion	278.51	13.20	173	77150	14051	79653014
Pain	277.86	13.20	170	77153	703632	78963433
Aggression	269.46	13.20	288	77035	50670	79616395
Dyspnoea	268.69	13.20	262	77061	856763	78810302
Muscle rigidity	266.49	13.20	191	77132	19691	79647374
Diabetes insipidus	261.51	13.20	119	77204	5118	79661947
Intentional self-injury	259.43	13.20	230	77093	32189	79634876
Psychomotor hyperactivity	258.86	13.20	176	77147	16673	79650392
Hypernatraemia	256.05	13.20	165	77158	14286	79652779
Overdose	256.04	13.20	557	76766	183649	79483416
Myoclonus	249.21	13.20	210	77113	27450	79639615
Arthralgia	245.93	13.20	124	77199	571679	79095386
Obsessive-compulsive disorder	244.43	13.20	118	77205	5809	79661256
Bipolar disorder	240.34	13.20	127	77196	7580	79659485
Somnolence	239.94	13.20	637	76686	238344	79428721
Granulocytopenia	239.03	13.20	145	77178	11286	79655779
Catatonia	236.04	13.20	131	77192	8625	79658440
Intentional overdose	220.26	13.20	380	76943	105580	79561485
Irritability	220.10	13.20	234	77089	40910	79626155
Hallucination, auditory	219.92	13.20	173	77150	20520	79646545
Drug abuse	204.79	13.20	473	76850	162218	79504847
Delusion	204.76	13.20	165	77158	20258	79646807
Delirium	199.28	13.20	321	77002	84306	79582759
Dyskinesia	188.83	13.20	225	77098	44548	79622517
Disorientation	185.95	13.20	265	77058	62511	79604554
Disturbance in attention	172.36	13.20	229	77094	50572	79616493
Antipsychotic drug level below therapeutic	164.26	13.20	57	77266	1181	79665884
Mental status changes	163.13	13.20	258	77065	66701	79600364
Infusion related reaction	162.75	13.20	17	77306	230220	79436845
Drug level increased	160.23	13.20	195	77128	39456	79627609
Coma	157.92	13.20	320	77003	100329	79566736
Polyuria	156.26	13.20	124	77199	14890	79652175
Rheumatoid arthritis	153.70	13.20	13	77310	208457	79458608
Altered state of consciousness	149.36	13.20	198	77125	43624	79623441
Cough	148.04	13.20	86	77237	366703	79300362
Hyperreflexia	146.72	13.20	95	77228	8290	79658775
Febrile neutropenia	144.42	13.20	25	77298	230974	79436091
Speech disorder	144.12	13.20	218	77105	54227	79612838
Restlessness	143.21	13.20	200	77123	46292	79620773
Dystonia	142.42	13.20	137	77186	21262	79645803
Joint swelling	140.70	13.20	52	77271	288594	79378471
Hypothyroidism	139.00	13.20	210	77113	52182	79614883
Depressed level of consciousness	138.41	13.20	296	77027	96356	79570709
Neurotoxicity	138.07	13.20	164	77159	32354	79634711
Electrocardiogram QT prolonged	136.62	13.20	283	77040	90103	79576962
Abnormal behaviour	135.74	13.20	172	77151	36249	79630816
Anaemia	133.34	13.20	141	77182	444874	79222191
Synovitis	131.63	13.20	3	77320	150731	79516334
Pruritus	131.08	13.20	114	77209	394534	79272531
Polydipsia	128.44	13.20	80	77243	6525	79660540
Bradyphrenia	126.27	13.20	95	77228	10545	79656520
Hypersensitivity	124.87	13.20	49	77274	262190	79404875
Euphoric mood	121.75	13.20	82	77241	7644	79659421
Peripheral swelling	119.42	13.20	56	77267	269561	79397504
Weight increased	118.73	13.20	558	76765	276828	79390237
Swelling	118.11	13.20	32	77291	216679	79450386
Schizoaffective disorder	117.32	13.20	52	77271	2100	79664965
Arthropathy	113.29	13.20	18	77305	177093	79489972
Pain in extremity	113.13	13.20	112	77211	364426	79302639
Disease progression	112.95	13.20	21	77302	184341	79482724
Pleurothotonus	112.61	13.20	53	77270	2463	79664602
Brugada syndrome	108.52	13.20	42	77281	1196	79665869
Back pain	108.27	13.20	82	77241	304098	79362967
Rash	107.84	13.20	252	77071	578106	79088959
Sinusitis	106.29	13.20	29	77294	195472	79471593
Blood creatine phosphokinase increased	105.86	13.20	212	77111	65878	79601187
Cerebellar syndrome	105.62	13.20	66	77257	5414	79661651
White blood cell count increased	100.48	13.20	223	77100	74410	79592655
Nasopharyngitis	100.29	13.20	61	77262	253820	79413245
Bruxism	99.75	13.20	57	77266	3969	79663096
Fatigue	99.70	13.20	514	76809	929213	78737852
Malignant neoplasm progression	98.80	13.20	9	77314	135981	79531084
Treatment noncompliance	97.66	13.20	179	77144	52089	79614976
Cognitive disorder	97.61	13.20	212	77111	69714	79597351
Leukocytosis	97.05	13.20	161	77162	43294	79623771
Systemic lupus erythematosus	96.77	13.20	5	77318	121144	79545921
Alopecia	96.51	13.20	52	77271	231303	79435762
Apathy	95.78	13.20	88	77235	12889	79654176
Logorrhoea	95.47	13.20	57	77266	4308	79662757
Body tinea	95.32	13.20	43	77280	1811	79665254
Nephropathy	94.06	13.20	77	77246	9661	79657404
Neutrophil count increased	92.82	13.20	128	77195	29268	79637797
Drug intolerance	90.44	13.20	74	77249	264045	79403020
Encephalopathy	90.30	13.20	201	77122	67196	79599869
Depression	88.99	13.20	431	76892	216359	79450706
Depressed mood	88.02	13.20	164	77159	48316	79618749
Hand deformity	87.28	13.20	3	77320	103916	79563149
Death	85.23	13.20	274	77049	566240	79100825
Priapism	83.67	13.20	53	77270	4452	79662613
Infection	83.66	13.20	67	77256	241645	79425420
Stomatitis	83.15	13.20	20	77303	146737	79520328
Bradykinesia	82.78	13.20	66	77257	7977	79659088
Camptocormia	82.67	13.20	27	77296	461	79666604
Atrial fibrillation	81.76	13.20	45	77278	197841	79469224
Grandiosity	81.66	13.20	28	77295	559	79666506
Disinhibition	81.53	13.20	43	77280	2555	79664510
Contraindicated product administered	80.82	13.20	26	77297	157512	79509553
Increased appetite	80.29	13.20	77	77246	11901	79655164
Glossodynia	80.27	13.20	5	77318	103332	79563733
Cogwheel rigidity	79.95	13.20	45	77278	3043	79664022
Arthritis	79.82	13.20	9	77314	114871	79552194
Mutism	79.42	13.20	41	77282	2331	79664734
Pneumonia	79.40	13.20	350	76973	659896	79007169
Enuresis	78.78	13.20	45	77278	3131	79663934
Intentional product use issue	78.22	13.20	25	77298	152087	79514978
Pericarditis	78.19	13.20	6	77317	104230	79562835
Oppositional defiant disorder	78.18	13.20	26	77297	471	79666594
Anxiety	78.05	13.20	459	76864	248053	79419012
Coordination abnormal	77.95	13.20	90	77233	17222	79649843
Interstitial lung disease	77.78	13.20	9	77314	112591	79554474
Hypercalcaemia	77.40	13.20	136	77187	38294	79628771
Libido increased	76.99	13.20	38	77285	1963	79665102
Renal cyst	75.61	13.20	82	77241	14650	79652415
Mental disorder	75.36	13.20	120	77203	31182	79635883
Homicidal ideation	75.23	13.20	45	77278	3412	79663653
Clonus	74.42	13.20	58	77265	6782	79660283
Abdominal discomfort	74.37	13.20	80	77243	250647	79416418
Wound	73.84	13.20	12	77311	116167	79550898
Poor quality sleep	73.34	13.20	100	77223	22622	79644443
Choreoathetosis	73.14	13.20	34	77289	1536	79665529
Affect lability	72.88	13.20	71	77252	11188	79655877
Paranoia	72.76	13.20	92	77231	19340	79647725
Jaundice cholestatic	72.74	13.20	71	77252	11213	79655852
Headache	72.44	13.20	357	76966	653415	79013650
Withdrawal syndrome	71.72	13.20	108	77215	26746	79640319
Aphasia	71.38	13.20	147	77176	46585	79620480
Urticaria	69.69	13.20	47	77276	185154	79481911
Poisoning	69.44	13.20	103	77220	25169	79641896
Parathyroid tumour benign	69.01	13.20	27	77296	792	79666273
Cardiac failure congestive	68.75	13.20	26	77297	142376	79524689
Glucose tolerance impaired	67.95	13.20	59	77264	8025	79659040
Electroencephalogram abnormal	67.79	13.20	50	77273	5384	79661681
Infection susceptibility increased	67.17	13.20	43	77280	3678	79663387
Inhibitory drug interaction	67.16	13.20	46	77277	4407	79662658
Poisoning deliberate	67.13	13.20	87	77236	18741	79648324
Insomnia	66.43	13.20	436	76887	244734	79422331
Hyperprolactinaemia	65.13	13.20	46	77277	4630	79662435
Gastrointestinal haemorrhage	64.87	13.20	31	77292	147688	79519377
Decreased eye contact	64.13	13.20	26	77297	839	79666226
Hyperparathyroidism primary	64.07	13.20	22	77301	441	79666624
Drooling	63.87	13.20	50	77273	5884	79661181
Stupor	63.58	13.20	53	77270	6819	79660246
Pyramidal tract syndrome	62.27	13.20	23	77300	574	79666491
General physical health deterioration	62.25	13.20	107	77216	275131	79391934
Hyperthermia	62.22	13.20	82	77241	17955	79649110
Thinking abnormal	61.93	13.20	70	77253	13091	79653974
Leukopenia	61.67	13.20	250	77073	116263	79550802
Acute kidney injury	60.99	13.20	770	76553	518634	79148431
Abdominal pain	60.92	13.20	185	77138	389384	79277681
Bipolar I disorder	60.54	13.20	33	77290	2096	79664969
Chronic kidney disease	59.91	13.20	170	77153	65984	79601081
Diarrhoea	59.45	13.20	557	76766	879932	78787133
Blister	59.04	13.20	21	77302	119455	79547610
Sepsis	58.89	13.20	107	77216	269321	79397744
Therapeutic product effect decreased	58.48	13.20	44	77279	163819	79503246
Drug level above therapeutic	58.33	13.20	56	77267	8667	79658398
Hostility	58.02	13.20	33	77290	2277	79664788
Psychiatric decompensation	57.56	13.20	40	77283	3923	79663142
Gait disturbance	57.40	13.20	371	76952	207135	79459930
Hypothermia	57.25	13.20	89	77234	22657	79644408
Asthma	56.84	13.20	30	77293	135065	79532000
Postural tremor	56.82	13.20	23	77300	739	79666326
Treatment failure	56.81	13.20	49	77274	170437	79496628
Thrombocytopenia	56.51	13.20	107	77216	265152	79401913
Drug reaction with eosinophilia and systemic symptoms	56.15	13.20	163	77160	64081	79602984
Impaired healing	55.82	13.20	9	77314	87646	79579419
Neuropathy peripheral	55.70	13.20	34	77289	141271	79525794
Abdominal pain upper	55.33	13.20	82	77241	223737	79443328
Chest pain	54.93	13.20	120	77203	282184	79384881
Myocarditis	54.65	13.20	85	77238	21648	79645417
Lethargy	54.32	13.20	188	77135	81104	79585961
Anger	53.09	13.20	74	77249	17088	79649977
Cardio-respiratory arrest	52.09	13.20	226	77097	108284	79558781
Hypertonia	51.35	13.20	48	77275	7184	79659881
Bronchitis	50.71	13.20	32	77291	130612	79536453
Abulia	50.36	13.20	23	77300	997	79666068
Blood prolactin increased	50.25	13.20	37	77286	3974	79663091
Psoriatic arthropathy	49.69	13.20	8	77315	77991	79589074
Pressure of speech	49.28	13.20	24	77299	1204	79665861
Urinary incontinence	49.26	13.20	117	77206	40792	79626273
Dystonic tremor	49.08	13.20	15	77308	204	79666861
Gestational diabetes	49.04	13.20	44	77279	6249	79660816
Galactorrhoea	48.78	13.20	35	77288	3611	79663454
Blood sodium increased	48.58	13.20	39	77284	4759	79662306
Hypokinesia	48.56	13.20	75	77248	18985	79648080
Myocardial infarction	47.95	13.20	65	77258	184064	79483001
Persecutory delusion	47.80	13.20	39	77284	4870	79662195
Musculoskeletal pain	47.25	13.20	20	77303	102334	79564731
Mental impairment	47.23	13.20	74	77249	18962	79648103
Distractibility	47.14	13.20	20	77303	725	79666340
Anticholinergic syndrome	46.80	13.20	34	77289	3577	79663488
Psychiatric symptom	46.73	13.20	45	77278	6990	79660075
Persistent depressive disorder	46.71	13.20	23	77300	1182	79665883
Drug hypersensitivity	46.66	13.20	142	77181	298774	79368291
Bundle branch block right	46.52	13.20	56	77267	11195	79655870
Depressive symptom	46.32	13.20	43	77280	6380	79660685
Tachycardia	45.63	13.20	312	77011	177456	79489609
Injection site erythema	45.59	13.20	10	77313	78187	79588878
Mucosal inflammation	45.44	13.20	9	77314	75571	79591494
Ascites	45.42	13.20	9	77314	75553	79591512
Electroconvulsive therapy	45.11	13.20	12	77311	95	79666970
Behaviour disorder	45.02	13.20	42	77281	6271	79660794
COVID-19	44.87	13.20	52	77271	157622	79509443
Pancytopenia	44.70	13.20	57	77266	165688	79501377
Mobility decreased	44.63	13.20	32	77291	122143	79544922
Productive cough	44.55	13.20	15	77308	88316	79578749
Self-injurious ideation	44.32	13.20	33	77290	3605	79663460
Balance disorder	43.76	13.20	201	77122	98656	79568409
Osteoarthritis	43.73	13.20	15	77308	87294	79579771
Muscle contractions involuntary	43.31	13.20	33	77290	3732	79663333
Renal oncocytoma	43.05	13.20	11	77312	73	79666992
Metabolic syndrome	42.98	13.20	29	77294	2711	79664354
Off label use	42.87	13.20	621	76702	906594	78760471
Muscle twitching	42.74	13.20	82	77241	24682	79642383
Fibromyalgia	42.36	13.20	6	77317	64334	79602731
Trismus	42.16	13.20	38	77285	5429	79661636
Action tremor	42.14	13.20	16	77307	432	79666633
Resting tremor	41.66	13.20	23	77300	1498	79665567
Hallucination	41.47	13.20	179	77144	85566	79581499
Electrocardiogram T wave abnormal	41.33	13.20	32	77291	3706	79663359
Mood altered	41.02	13.20	67	77256	17780	79649285
Therapeutic product effect variable	40.75	13.20	25	77298	1984	79665081
Blunted affect	40.53	13.20	16	77307	481	79666584
Haemodialysis	40.14	13.20	67	77256	18101	79648964
Gastrointestinal disorder	39.65	13.20	36	77287	122169	79544896
Discomfort	39.59	13.20	38	77285	125579	79541486
Apraxia	39.46	13.20	28	77295	2839	79664226
Paraesthesia	39.43	13.20	69	77254	176254	79490811
Major depression	39.28	13.20	46	77277	8934	79658131
Malaise	39.21	13.20	296	77027	489573	79177492
Sexually inappropriate behaviour	39.10	13.20	16	77307	529	79666536
Visuospatial deficit	39.01	13.20	9	77314	36	79667029
Feelings of worthlessness	38.90	13.20	16	77307	536	79666529
Electrocardiogram T wave inversion	38.81	13.20	36	77287	5336	79661729
Oculogyric crisis	38.72	13.20	28	77295	2924	79664141
Cerebellar atrophy	38.67	13.20	20	77303	1141	79665924
Asterixis	38.56	13.20	27	77296	2680	79664385
Oedema peripheral	38.55	13.20	121	77202	252167	79414898
Lower respiratory tract infection	38.54	13.20	41	77282	129179	79537886
International normalised ratio increased	38.40	13.20	17	77306	84704	79582361
Lung disorder	38.39	13.20	15	77308	80542	79586523
Wheezing	38.29	13.20	34	77289	116630	79550435
Pleural effusion	38.09	13.20	51	77272	145211	79521854
Urinary retention	37.85	13.20	131	77192	56499	79610566
Failure to suspend medication	37.74	13.20	15	77308	459	79666606
Miosis	37.27	13.20	60	77263	15729	79651336
Haemorrhage	37.21	13.20	21	77302	91097	79575968
Agranulocytosis	37.20	13.20	112	77211	44918	79622147
Melaena	37.13	13.20	7	77316	60883	79606182
Pneumonitis	37.11	13.20	7	77316	60853	79606212
Product use issue	36.95	13.20	94	77229	209728	79457337
Language disorder	36.60	13.20	28	77295	3186	79663879
Personality disorder	36.53	13.20	37	77286	6109	79660956
Restless legs syndrome	36.50	13.20	68	77255	20024	79647041
Blood pressure fluctuation	36.39	13.20	10	77313	67135	79599930
Cerebrovascular accident	36.35	13.20	59	77264	155233	79511832
Anaphylactic reaction	36.11	13.20	18	77305	83725	79583340
Psychomotor skills impaired	35.73	13.20	34	77289	5203	79661862
Soft tissue injury	35.71	13.20	22	77301	1759	79665306
Long QT syndrome	35.67	13.20	36	77287	5919	79661146
Septic shock	35.48	13.20	40	77283	122761	79544304
Schizoaffective disorder bipolar type	35.45	13.20	12	77311	230	79666835
Neutrophilia	35.23	13.20	41	77282	7910	79659155
Cardiac failure	35.16	13.20	60	77263	154782	79512283
Feeling guilty	34.94	13.20	17	77306	851	79666214
Sleep-related eating disorder	34.94	13.20	16	77307	698	79666367
Rhinorrhoea	34.89	13.20	15	77308	76059	79591006
Antipsychotic drug level decreased	34.88	13.20	19	77304	1205	79665860
Epistaxis	34.83	13.20	34	77289	111481	79555584
Delusion of grandeur	34.74	13.20	20	77303	1412	79665653
Electrocardiogram abnormal	34.70	13.20	60	77263	16677	79650388
Impulsive behaviour	34.65	13.20	26	77297	2874	79664191
Sinus bradycardia	34.60	13.20	76	77247	25171	79641894
Nausea	34.53	13.20	688	76635	956508	78710557
Psychomotor retardation	34.53	13.20	36	77287	6148	79660917
Hypomagnesaemia	34.34	13.20	3	77320	46908	79620157
Social avoidant behaviour	34.27	13.20	32	77291	4782	79662283
Dyspnoea exertional	34.24	13.20	21	77302	87052	79580013
Muscle spasms	34.19	13.20	74	77249	174656	79492409
Goitre	34.12	13.20	34	77289	5505	79661560
Acute psychosis	34.11	13.20	30	77293	4150	79662915
Hyperthyroidism	34.07	13.20	70	77253	22139	79644926
Acute myocardial infarction	34.07	13.20	16	77307	77020	79590045
Electrocardiogram QRS complex prolonged	33.94	13.20	47	77276	10786	79656279
Decreased appetite	33.90	13.20	194	77129	342224	79324841
Hyperkinesia	33.79	13.20	25	77298	2704	79664361
Injection site pain	33.62	13.20	46	77277	129792	79537273
Neoplasm progression	33.60	13.20	5	77318	51677	79615388
Erythema	33.47	13.20	108	77215	223182	79443883
Blood thyroid stimulating hormone decreased	33.22	13.20	34	77289	5682	79661383
Otospondylomegaepiphyseal dysplasia	33.06	13.20	8	77315	41	79667024
Nodal rhythm	32.85	13.20	26	77297	3109	79663956
Sluggishness	32.71	13.20	36	77287	6536	79660529
Platelet count decreased	32.16	13.20	90	77233	194574	79472491
Adams-Stokes syndrome	32.00	13.20	10	77313	147	79666918
Toxic encephalopathy	31.96	13.20	47	77276	11393	79655672
Patient restraint	31.44	13.20	9	77314	96	79666969
Speech sound disorder	31.32	13.20	8	77315	53	79667012
Hypoaesthesia	31.07	13.20	81	77242	179271	79487794
Protein C increased	30.95	13.20	9	77314	102	79666963
Plasma cell myeloma	30.67	13.20	7	77316	53252	79613813
Influenza	30.56	13.20	49	77274	129557	79537508
Status epilepticus	30.56	13.20	72	77251	24969	79642096
Hallucination, olfactory	30.55	13.20	13	77310	475	79666590
Oncocytoma	30.54	13.20	7	77316	27	79667038
Dysphemia	30.44	13.20	26	77297	3458	79663607
Seizure	30.33	13.20	298	77025	188536	79478529
Differential white blood cell count abnormal	30.25	13.20	21	77302	2056	79665009
Drug withdrawal syndrome	30.24	13.20	88	77235	34630	79632435
Tachyphrenia	30.22	13.20	21	77302	2059	79665006
Injection site pruritus	30.16	13.20	3	77320	42280	79624785
Echolalia	30.11	13.20	12	77311	370	79666695
Post-traumatic neck syndrome	30.10	13.20	21	77302	2073	79664992
Respiratory arrest	30.05	13.20	123	77200	57427	79609638
Inflammation	29.96	13.20	28	77295	93725	79573340
Hyporeflexia	29.90	13.20	26	77297	3542	79663523
Upper respiratory tract infection	29.40	13.20	27	77296	91141	79575924
Upper gastrointestinal haemorrhage	29.35	13.20	3	77320	41377	79625688
Memory impairment	29.18	13.20	197	77126	111537	79555528
Metabolic encephalopathy	29.13	13.20	40	77283	9107	79657958
Chest discomfort	29.09	13.20	56	77267	137988	79529077
Dysphoria	29.05	13.20	29	77294	4705	79662360
Nephropathy toxic	28.58	13.20	62	77261	20357	79646708
Antipsychotic drug level	28.43	13.20	6	77317	14	79667051
Gambling disorder	28.38	13.20	20	77303	2006	79665059
Coronary artery disease	28.34	13.20	14	77309	65460	79601605
Hyperhidrosis	28.32	13.20	247	77076	151245	79515820
Papillary thyroid cancer	28.29	13.20	22	77301	2564	79664501
Nystagmus	28.12	13.20	41	77282	9863	79657202
Poverty of speech	28.09	13.20	13	77310	581	79666484
Blood creatinine increased	28.05	13.20	251	77072	154806	79512259
Haematoma	27.86	13.20	8	77315	52187	79614878
Convulsive threshold lowered	27.82	13.20	15	77308	932	79666133
Parkinsonian gait	27.81	13.20	15	77308	933	79666132
Skin ulcer	27.65	13.20	9	77314	54141	79612924
Affective disorder	27.43	13.20	37	77286	8282	79658783
Hypoxia	27.32	13.20	36	77287	103207	79563858
Bone pain	27.19	13.20	10	77313	55732	79611333
Blood pressure increased	27.18	13.20	109	77214	211251	79455814
Thrombosis	27.01	13.20	25	77298	84075	79582990
Impaired work ability	26.69	13.20	59	77264	19622	79647443
Oxygen saturation decreased	26.63	13.20	53	77270	128994	79538071
Movement disorder	26.60	13.20	72	77251	27187	79639878
Sternal fracture	26.55	13.20	21	77302	2509	79664556
Knee arthroplasty	26.31	13.20	5	77318	43243	79623822
Osteonecrosis of jaw	26.29	13.20	5	77318	43221	79623844
Deprescribing error	26.21	13.20	6	77317	23	79667042
Hyperammonaemia	25.97	13.20	42	77281	11051	79656014
Hyperleukocytosis	25.97	13.20	21	77302	2589	79664476
Myelosuppression	25.96	13.20	4	77319	40292	79626773
Haematochezia	25.92	13.20	28	77295	87617	79579448
Haemoptysis	25.75	13.20	11	77312	55988	79611077
Hallucination, visual	25.72	13.20	80	77243	32649	79634416
Angina pectoris	25.71	13.20	9	77314	51723	79615342
Sinus arrest	25.64	13.20	24	77299	3598	79663467
Injection site swelling	25.58	13.20	7	77316	47125	79619940
Induced abortion failed	25.47	13.20	9	77314	197	79666868
Hereditary ataxia	25.44	13.20	6	77317	27	79667038
Gaze palsy	25.39	13.20	22	77301	2983	79664082
Acquired cystic kidney disease	25.14	13.20	7	77316	67	79666998
Reflexes abnormal	25.12	13.20	14	77309	929	79666136
Antidepressant drug level increased	24.89	13.20	11	77312	441	79666624
Substance abuse	24.85	13.20	40	77283	10486	79656579
Diverticulitis	24.60	13.20	7	77316	45929	79621136
Fluid retention	24.57	13.20	19	77304	69790	79597275
Dyslipidaemia	24.50	13.20	42	77281	11591	79655474
Hypersexuality	24.50	13.20	17	77306	1663	79665402
Staphylococcal infection	24.43	13.20	13	77310	58282	79608783
Maternal exposure during pregnancy	24.16	13.20	61	77262	136477	79530588
Impaired quality of life	24.05	13.20	47	77276	14339	79652726
Bone density decreased	24.03	13.20	45	77278	13302	79653763
Myocarditis septic	24.00	13.20	6	77317	36	79667029
Flat affect	23.72	13.20	18	77305	2023	79665042
Crying	23.63	13.20	62	77261	22981	79644084
Chronic obstructive pulmonary disease	23.41	13.20	29	77294	85390	79581675
Dry skin	23.31	13.20	19	77304	67976	79599089
Ideas of reference	23.22	13.20	8	77315	162	79666903
Ear infection	23.16	13.20	3	77320	34429	79632636
Irritable bowel syndrome	23.12	13.20	16	77307	62225	79604840
Blood thyroid stimulating hormone increased	23.06	13.20	37	77286	9671	79657394
Mood swings	23.01	13.20	56	77267	19824	79647241
Neurological symptom	22.99	13.20	35	77288	8748	79658317
Haemoglobin decreased	22.97	13.20	124	77199	221995	79445070
Conversion disorder	22.94	13.20	17	77306	1844	79665221
Weight decreased	22.87	13.20	227	77096	354971	79312094
Cerebral haemorrhage	22.55	13.20	14	77309	57659	79609406
Cerebellar ataxia	22.46	13.20	17	77306	1904	79665161
Injection site bruising	22.42	13.20	6	77317	40996	79626069
Throat irritation	22.37	13.20	6	77317	40940	79626125
Water intoxication	22.01	13.20	12	77311	762	79666303
Ill-defined disorder	21.85	13.20	19	77304	65856	79601209
Sexual dysfunction	21.84	13.20	32	77291	7731	79659334
Mydriasis	21.82	13.20	51	77272	17592	79649473
Bradycardia	21.79	13.20	214	77109	135343	79531722
Osteomyelitis	21.78	13.20	3	77320	32862	79634203
Cystitis	21.75	13.20	12	77311	52720	79614345
Hallucinations, mixed	21.71	13.20	30	77293	6869	79660196
Oropharyngeal pain	21.64	13.20	46	77277	109307	79557758
Localised infection	21.51	13.20	5	77318	37570	79629495
Gastric disorder	21.39	13.20	5	77318	37428	79629637
Dialysis	21.36	13.20	52	77271	18410	79648655
Progressive supranuclear palsy	21.35	13.20	7	77316	121	79666944
Clostridium difficile colitis	21.27	13.20	3	77320	32280	79634785
Cholelithiasis	21.06	13.20	104	77219	52560	79614505
Electric shock sensation	20.85	13.20	12	77311	847	79666218
Rectal haemorrhage	20.81	13.20	26	77297	76274	79590791
Flight of ideas	20.81	13.20	12	77311	850	79666215
Negativism	20.80	13.20	12	77311	851	79666214
Rhabdomyolysis	20.77	13.20	171	77152	102960	79564105
Encopresis	20.74	13.20	7	77316	133	79666932
Hyperlipidaemia	20.71	13.20	64	77259	26029	79641036
High-grade B-cell lymphoma	20.64	13.20	7	77316	135	79666930
Ileus paralytic	20.61	13.20	35	77288	9585	79657480
Sleep disorder	20.57	13.20	148	77175	85529	79581536
Thought blocking	20.53	13.20	8	77315	232	79666833
Product dose omission issue	20.52	13.20	148	77175	247389	79419676
Purpura	20.50	13.20	53	77270	19474	79647591
Medication error	20.36	13.20	125	77198	68517	79598548
Haematuria	20.34	13.20	22	77301	68814	79598251
Delusion of reference	20.08	13.20	7	77316	147	79666918
Clear cell renal cell carcinoma	20.05	13.20	18	77305	2558	79664507
Hypokalaemia	19.99	13.20	72	77251	143968	79523097
Abdominal distension	19.99	13.20	55	77268	119595	79547470
Prostate cancer	19.91	13.20	4	77319	33264	79633801
Atrioventricular block first degree	19.91	13.20	40	77283	12451	79654614
Sciatica	19.87	13.20	4	77319	33218	79633847
Lactate pyruvate ratio increased	19.81	13.20	6	77317	79	79666986
Merycism	19.79	13.20	8	77315	256	79666809
Dysphagia	19.72	13.20	193	77130	121943	79545122
Decreased interest	19.71	13.20	21	77302	3676	79663389
Intention tremor	19.66	13.20	11	77312	735	79666330
Muscle contracture	19.65	13.20	17	77306	2300	79664765
International normalised ratio abnormal	19.55	13.20	26	77297	5742	79661323
Bacteraemia	19.54	13.20	4	77319	32820	79634245
Cerebral atrophy	19.49	13.20	31	77292	8044	79659021
Eosinophil count decreased	19.37	13.20	20	77303	3376	79663689
Drug level decreased	19.33	13.20	43	77280	14359	79652706
Torticollis	19.21	13.20	17	77306	2370	79664695
Lactic acidosis	19.16	13.20	24	77299	70335	79596730
Autonomic nervous system imbalance	19.07	13.20	23	77300	4607	79662458
Diabetic coma	19.05	13.20	13	77310	1238	79665827
Myalgia	18.99	13.20	104	77219	185537	79481528
Thyrotoxic crisis	18.74	13.20	13	77310	1271	79665794
Osteoporosis	18.70	13.20	15	77308	54097	79612968
Angioedema	18.63	13.20	28	77295	76007	79591058
Choking	18.39	13.20	38	77285	12063	79655002
Suspected suicide	18.23	13.20	35	77288	10541	79656524
Blood pressure systolic increased	18.09	13.20	23	77300	66963	79600102
Oscillopsia	18.03	13.20	7	77316	201	79666864
Histrionic personality disorder	17.94	13.20	5	77318	48	79667017
Incoherent	17.84	13.20	29	77294	7663	79659402
Generalised tonic-clonic seizure	17.76	13.20	87	77236	43823	79623242
Irregular sleep wake rhythm disorder	17.62	13.20	8	77315	342	79666723
Thyroiditis	17.55	13.20	22	77301	4583	79662482
Secondary tic	17.54	13.20	4	77319	15	79667050
Obesity	17.49	13.20	74	77249	35051	79632014
Hepatic cirrhosis	17.47	13.20	6	77317	34900	79632165
Psoriasis	17.46	13.20	38	77285	89549	79577516
Urinary tract infection	17.42	13.20	176	77147	274336	79392729
Unmasking of previously unidentified disease	17.26	13.20	15	77308	2042	79665023
Megacolon	17.15	13.20	19	77304	3476	79663589
Femur fracture	17.13	13.20	8	77315	38644	79628421
Sinus tachycardia	17.04	13.20	76	77247	36832	79630233
Blood citric acid increased	17.01	13.20	5	77318	59	79667006
Mouth ulceration	16.93	13.20	8	77315	38386	79628679
Nephrolithiasis	16.92	13.20	16	77307	53275	79613790
Pulmonary oedema	16.74	13.20	38	77285	88216	79578849
Social anxiety disorder	16.65	13.20	9	77314	562	79666503
Bursitis	16.54	13.20	7	77316	35837	79631228
Blood urea increased	16.51	13.20	92	77231	48698	79618367
Fungal infection	16.50	13.20	10	77313	41738	79625327
Obstructive airways disorder	16.47	13.20	5	77318	31454	79635611
Compulsions	16.45	13.20	8	77315	400	79666665
Diabetic hyperosmolar coma	16.38	13.20	10	77313	787	79666278
Therapy interrupted	16.37	13.20	5	77318	31336	79635729
Pulmonary mass	16.35	13.20	4	77319	29030	79638035
Osteonecrosis	16.17	13.20	5	77318	31090	79635975
Blood triglycerides increased	16.14	13.20	51	77272	20989	79646076
Urine output increased	16.07	13.20	15	77308	2241	79664824
Body mass index increased	16.03	13.20	14	77309	1919	79665146
Prescribed overdose	16	13.20	76	77247	37807	79629258
Activation syndrome	15.90	13.20	7	77316	278	79666787
Hip fracture	15.90	13.20	5	77318	30756	79636309
Staring	15.86	13.20	16	77307	2629	79664436
Flatulence	15.85	13.20	11	77312	42713	79624352
Dry eye	15.82	13.20	8	77315	36923	79630142
Clostridium difficile infection	15.82	13.20	11	77312	42674	79624391
Psychotic disorder due to a general medical condition	15.76	13.20	7	77316	284	79666781
Colitis ulcerative	15.69	13.20	7	77316	34735	79632330
Pain in jaw	15.69	13.20	13	77310	46138	79620927
Psychotic symptom	15.60	13.20	16	77307	2681	79664384
Full blood count abnormal	15.58	13.20	10	77313	40464	79626601
Limbic encephalitis	15.52	13.20	10	77313	865	79666200
Tri-iodothyronine decreased	15.51	13.20	7	77316	295	79666770
Injection site haemorrhage	15.39	13.20	4	77319	27866	79639199
Metabolic disorder	15.38	13.20	30	77293	9140	79657925
Hyperammonaemic encephalopathy	15.36	13.20	21	77302	4761	79662304
Thyroid function test abnormal	15.31	13.20	17	77306	3117	79663948
Antidepressant drug level above therapeutic	15.23	13.20	9	77314	667	79666398
Eosinophilia	15.01	13.20	85	77238	45260	79621805
Potentiating drug interaction	14.97	13.20	29	77294	8790	79658275
Small intestinal obstruction	14.89	13.20	4	77319	27268	79639797
Illness	14.73	13.20	14	77309	46497	79620568
Basal cell carcinoma	14.71	13.20	9	77314	37366	79629699
Non-high-density lipoprotein cholesterol increased	14.70	13.20	7	77316	334	79666731
Refusal of treatment by patient	14.58	13.20	29	77294	8962	79658103
Excessive masturbation	14.57	13.20	5	77318	100	79666965
Hepatic failure	14.56	13.20	23	77300	61189	79605876
Polydipsia psychogenic	14.39	13.20	6	77317	208	79666857
Electrocardiogram T wave amplitude decreased	14.37	13.20	9	77314	741	79666324
Cyclothymic disorder	14.29	13.20	6	77317	212	79666853
Hepatotoxicity	14.29	13.20	92	77231	51260	79615805
Tic	14.25	13.20	16	77307	2970	79664095
Autoimmune thyroiditis	14.22	13.20	19	77304	4214	79662851
Weight	14.12	13.20	4	77319	41	79667024
Parasomnia	14.05	13.20	8	77315	553	79666512
Night sweats	13.95	13.20	18	77305	52077	79614988
Cardiac hypertrophy	13.91	13.20	12	77311	1618	79665447
Device related infection	13.86	13.20	8	77315	34286	79632779
Sleep apnoea syndrome	13.85	13.20	71	77252	36407	79630658
Consciousness fluctuating	13.85	13.20	13	77310	1956	79665109
Impaired self-care	13.77	13.20	15	77308	2692	79664373
Loss of personal independence in daily activities	13.75	13.20	52	77271	102528	79564537
Food craving	13.74	13.20	12	77311	1645	79665420
Coagulopathy	13.72	13.20	9	77314	35997	79631068
Anaphylactic shock	13.71	13.20	9	77314	35987	79631078
Nasal congestion	13.69	13.20	34	77289	76518	79590547
Fluid intake reduced	13.64	13.20	23	77300	6265	79660800
Tension	13.63	13.20	19	77304	4385	79662680
Left atrial dilatation	13.54	13.20	16	77307	3137	79663928
Lung neoplasm malignant	13.53	13.20	5	77318	27787	79639278
Neoplasm malignant	13.47	13.20	7	77316	31803	79635262
Oral pain	13.46	13.20	7	77316	31791	79635274
Toxic cardiomyopathy	13.38	13.20	7	77316	409	79666656
Oedema	13.35	13.20	65	77258	119515	79547550
Frequent bowel movements	13.27	13.20	6	77317	29533	79637532

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05AN01	NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Lithium
CHEBI has role	CHEBI:35477	antimanic drugs
MeSH PA	D000928	Antidepressive Agents
MeSH PA	D018692	Antimanic Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D014149	Tranquilizing Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Bipolar disorder	indication	13746004	DOID:3312
Pain	indication	22253000
Rheumatoid arthritis	indication	69896004	DOID:7148
Bipolar disorder in remission	indication	85248005
Bipolar affective disorder, current episode manic	indication	191618007
Headache disorder	indication	230461009
Dysmenorrhea	indication	266599000
Fever	indication	386661006
Osteoarthritis	indication	396275006
Juvenile rheumatoid arthritis	indication	410795001
Vascular headache	off-label use	128187005
Bipolar affective disorder, current episode depression	off-label use	191627008	DOID:3312
Cluster Headache Prevention	off-label use
Rapid Cycling Bipolar Affective Disorder	off-label use
Psoriasis	contraindication	9014002	DOID:8893
Diabetes insipidus	contraindication	15771004	DOID:9409
Polyuria	contraindication	28442001
Hypothyroidism	contraindication	40930008	DOID:1459
Conduction disorder of the heart	contraindication	44808001
Chronic heart failure	contraindication	48447003
Acute infectious disease	contraindication	63171007
Hyponatremia	contraindication	89627008
Kidney disease	contraindication	90708001	DOID:557
Organic mental disorder	contraindication	111479008
Plaque psoriasis	contraindication	200965009
Pregnancy, function	contraindication	289908002
Breastfeeding (mother)	contraindication	413712001
Severe dehydration	contraindication	450316000
Lithium Toxicity	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glycogen synthase kinase-3	Kinase	P49840 P49841	GSK3A_HUMAN GSK3B_HUMAN	INHIBITOR				CHEMBL	CHEMBL
Inositol-1(or 4)-monophosphatase 1	Enzyme	P29218	IMPA1_HUMAN	INHIBITOR				CHEMBL	CHEMBL

External reference:

ID	Source
4018007	VUID
N0000146351	NUI
D00801	KEGG_DRUG
4018007	VANDF
4019803	VANDF
C0085217	UMLSCUI
CHEBI:6504	CHEBI
CHEBI:30145	CHEBI
CHEMBL1200826	ChEMBL_ID
D016651	MESH_DESCRIPTOR_UI
DB14509	DRUGBANK_ID
2BMD2GNA4V	UNII
11125	PUBCHEM_CID
42351	RXNORM
1990	MMSL
4986	MMSL
d00061	MMSL
001532	NDDF
001533	NDDF
16977003	SNOMEDCT_US
321719003	SNOMEDCT_US
387095003	SNOMEDCT_US
85899009	SNOMEDCT_US
C0023870	UMLSCUI
CHEMBL2146126	ChEMBL_ID
7439-93-2	SECONDARY_CAS_RN
3028194	PUBCHEM_CID
D008094	MESH_DESCRIPTOR_UI
9FN79X2M3F	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0020	TABLET, EXTENDED RELEASE	450 mg	ORAL	ANDA	16 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0020	TABLET, EXTENDED RELEASE	450 mg	ORAL	ANDA	16 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0020	TABLET, EXTENDED RELEASE	450 mg	ORAL	ANDA	16 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0021	TABLET, EXTENDED RELEASE	300 mg	ORAL	ANDA	13 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0021	TABLET, EXTENDED RELEASE	300 mg	ORAL	ANDA	13 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0021	TABLET, EXTENDED RELEASE	300 mg	ORAL	ANDA	13 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-2526	CAPSULE, GELATIN COATED	150 mg	ORAL	NDA	26 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-2526	CAPSULE, GELATIN COATED	150 mg	ORAL	NDA	26 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-2526	CAPSULE, GELATIN COATED	150 mg	ORAL	NDA	26 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-2527	CAPSULE, GELATIN COATED	300 mg	ORAL	NDA	26 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-2527	CAPSULE, GELATIN COATED	300 mg	ORAL	NDA	26 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-2527	CAPSULE, GELATIN COATED	300 mg	ORAL	NDA	26 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-2531	CAPSULE, GELATIN COATED	600 mg	ORAL	NDA	26 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-2531	CAPSULE, GELATIN COATED	600 mg	ORAL	NDA	26 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-2531	CAPSULE, GELATIN COATED	600 mg	ORAL	NDA	26 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-4527	TABLET	300 mg	ORAL	NDA	26 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-4527	TABLET	300 mg	ORAL	NDA	26 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-4527	TABLET	300 mg	ORAL	NDA	26 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-8526	CAPSULE, GELATIN COATED	150 mg	ORAL	NDA	26 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-8526	CAPSULE, GELATIN COATED	150 mg	ORAL	NDA	26 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-8526	CAPSULE, GELATIN COATED	150 mg	ORAL	NDA	26 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-8527	CAPSULE, GELATIN COATED	300 mg	ORAL	NDA	26 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-8527	CAPSULE, GELATIN COATED	300 mg	ORAL	NDA	26 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-8527	CAPSULE, GELATIN COATED	300 mg	ORAL	NDA	26 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-8528	TABLET	300 mg	ORAL	NDA	26 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-8528	TABLET	300 mg	ORAL	NDA	26 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-8528	TABLET	300 mg	ORAL	NDA	26 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-8531	CAPSULE, GELATIN COATED	600 mg	ORAL	NDA	26 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-8531	CAPSULE, GELATIN COATED	600 mg	ORAL	NDA	26 sections
Lithium Carbonate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-8531	CAPSULE, GELATIN COATED	600 mg	ORAL	NDA	26 sections