All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

sodium bicarbonate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4205	144-55-8

Description:

Molecule	Description
Synonyms: sodium bicarbonate sodium hydrogen carbonate	A white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. Molecular weight: 84.01 Formula: CHNaO3 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Oct. 28, 1981	FDA	ALCON

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pemphigus	1019.30	9.82	10	371313	183716	62933983
Contraindicated product administered	852.69	9.82	128	371195	217520	62900179
Drug intolerance	846.84	9.82	373	370950	308288	62809411
Synovitis	843.36	9.82	66	371257	186852	62930847
Hand deformity	818.24	9.82	25	371298	159432	62958267
Drug ineffective	804.49	9.82	3274	368049	1041491	62076208
Hypomagnesaemia	704.55	9.82	855	370468	27882	63089817
Systemic lupus erythematosus	704.39	9.82	177	371146	208741	62908958
Glossodynia	685.10	9.82	112	371211	178764	62938935
Treatment failure	656.94	9.82	176	371147	198867	62918832
Anti-cyclic citrullinated peptide antibody positive	645.91	9.82	6	371317	116206	63001493
Wound	614.64	9.82	107	371216	163156	62954543
Drug interaction	608.46	9.82	2803	368520	226328	62891371
Acute kidney injury	598.88	9.82	3082	368241	260333	62857366
Therapeutic product effect decreased	509.90	9.82	246	371077	192941	62924758
Hyponatraemia	501.32	9.82	1617	369706	110283	63007416
Arthropathy	494.86	9.82	389	370934	234403	62883296
Tubulointerstitial nephritis	472.98	9.82	583	370740	19320	63098379
Rheumatoid factor positive	470.72	9.82	4	371319	84402	63033297
Chronic kidney disease	459.83	9.82	896	370427	44502	63073197
Pericarditis	452.04	9.82	107	371216	131472	62986227
Joint swelling	439.70	9.82	777	370546	326889	62790810
Duodenal ulcer perforation	428.87	9.82	19	371304	87190	63030509
Infusion related reaction	412.83	9.82	497	370826	245024	62872675
Hepatic enzyme increased	406.70	9.82	351	370972	201977	62915722
Maternal exposure during pregnancy	384.44	9.82	432	370891	219630	62898069
Helicobacter infection	373.77	9.82	50	371273	92735	63024964
Drug hypersensitivity	371.32	9.82	789	370534	309898	62807801
Discomfort	357.97	9.82	273	371050	167101	62950598
Rheumatoid arthritis	349.33	9.82	592	370731	253227	62864472
Muscle injury	335.93	9.82	10	371313	65335	63052364
Abdominal discomfort	327.06	9.82	886	370437	319999	62797700
Alopecia	321.24	9.82	963	370360	336573	62781126
Folliculitis	316.45	9.82	25	371298	70292	63047407
Swelling	316.04	9.82	715	370608	274663	62843036
Product use issue	315.84	9.82	501	370822	220019	62897680
Hypocalcaemia	315.15	9.82	621	370702	31092	63086607
Subacute cutaneous lupus erythematosus	282.29	9.82	182	371141	2461	63115238
Hypersensitivity	276.98	9.82	837	370486	291848	62825851
Off label use	255.39	9.82	2619	368704	671843	62445856
Sleep disorder due to general medical condition, insomnia type	245.31	9.82	15	371308	52202	63065497
Orthostatic hypotension	233.19	9.82	596	370727	35564	63082135
Creatinine renal clearance decreased	210.99	9.82	358	370965	15950	63101749
Irritable bowel syndrome	206.72	9.82	112	371211	82300	63035399
C-reactive protein abnormal	205.70	9.82	17	371306	46079	63071620
Impaired healing	199.74	9.82	183	371140	102359	63015340
Blood calcium decreased	195.01	9.82	459	370864	25992	63091707
Renal injury	190.46	9.82	255	371068	9184	63108515
Sedation complication	183.56	9.82	307	371016	13515	63104184
Diarrhoea	179.33	9.82	5459	365864	709907	62407792
Cognitive disorder	174.59	9.82	718	370605	55097	63062602
Hypokalaemia	173.94	9.82	1121	370202	102683	63015016
Musculoskeletal stiffness	173.01	9.82	530	370793	184088	62933611
Balance disorder	162.48	9.82	945	370378	83477	63034222
Constipation	156.90	9.82	2007	369316	222936	62894763
Exposure during pregnancy	141.16	9.82	453	370870	155094	62962605
Type 2 diabetes mellitus	140.54	9.82	101	371222	63767	63053932
Pain	134.04	9.82	3305	368018	737323	62380376
Ill-defined disorder	133.52	9.82	169	371154	81586	63036113
Stomatitis	123.79	9.82	407	370916	138318	62979381
Blood cholesterol increased	121.34	9.82	228	371095	93804	63023895
Sedation	118.03	9.82	495	370828	38314	63079385
Fall	116.81	9.82	3062	368261	389272	62728427
Nasopharyngitis	116.77	9.82	939	370384	253318	62864381
Psoriatic arthropathy	112.81	9.82	228	371095	91292	63026407
End stage renal disease	110.11	9.82	164	371159	6529	63111170
Infection	110.05	9.82	836	370487	228337	62889362
Rash	108.71	9.82	2476	368847	558395	62559304
Blister	106.97	9.82	394	370929	129420	62988279
Vomiting	105.22	9.82	4133	367190	555484	62562215
Metabolic alkalosis	104.01	9.82	108	371215	2953	63114746
Hypotension	103.87	9.82	2202	369121	270402	62847297
Intentional product use issue	100.95	9.82	395	370928	127497	62990202
Therapeutic product effect incomplete	100.15	9.82	384	370939	124672	62993027
Liver injury	99.97	9.82	124	371199	60396	63057303
Arthralgia	97.03	9.82	2564	368759	567146	62550553
Tetany	95.25	9.82	85	371238	1916	63115783
Sinusitis	92.49	9.82	863	370460	225790	62891909
Abdominal pain	90.94	9.82	2303	369020	291153	62826546
Drug tolerance decreased	85.24	9.82	4	371319	17469	63100230
Hip arthroplasty	84.75	9.82	92	371231	47554	63070145
Condition aggravated	84.02	9.82	1754	369569	400463	62717236
Therapy non-responder	83.74	9.82	201	371122	75700	63041999
Completed suicide	83.03	9.82	505	370818	145168	62972531
Weight increased	82.04	9.82	1054	370269	259738	62857961
Lip swelling	81.41	9.82	379	370944	30684	63087015
Cogwheel rigidity	80.79	9.82	77	371246	1893	63115806
Swollen tongue	80.03	9.82	409	370914	34391	63083308
Pancreatitis acute	79.89	9.82	343	370980	26823	63090876
Gastric pH decreased	79.47	9.82	52	371271	722	63116977
Plasma cell myeloma	79.12	9.82	417	370906	35488	63082211
Device expulsion	78.44	9.82	54	371269	34868	63082831
Abortion spontaneous	76.59	9.82	98	371225	47097	63070602
Renal failure	72.93	9.82	1028	370295	116624	63001075
Rhabdomyolysis	71.95	9.82	472	370851	43479	63074220
Gastrointestinal disorder	70.65	9.82	463	370860	130776	62986923
Dehydration	69.78	9.82	1412	369911	171942	62945757
Lethargy	69.56	9.82	563	370760	55444	63062255
Electrocardiogram QT prolonged	67.86	9.82	587	370736	58943	63058756
Gastrointestinal haemorrhage	67.81	9.82	750	370573	80426	63037273
Prescribed overdose	66.42	9.82	61	371262	34092	63083607
Hyperkalaemia	65.77	9.82	542	370781	53661	63064038
Haematemesis	65.50	9.82	351	370972	30061	63087638
Bone erosion	63.65	9.82	13	371310	17704	63099995
Adverse event	63.18	9.82	194	371129	67365	63050334
Red blood cell sedimentation rate increased	62.79	9.82	100	371223	43882	63073817
Malaise	62.59	9.82	3003	368320	412951	62704748
Disorientation	62.35	9.82	420	370903	39032	63078667
International normalised ratio increased	62.23	9.82	475	370848	45950	63071749
Rheumatoid nodule	60.78	9.82	13	371310	17142	63100557
Parkinsonism	60.11	9.82	165	371158	10274	63107425
Depressed level of consciousness	60.09	9.82	591	370732	61487	63056212
Hypoparathyroidism	58.74	9.82	41	371282	637	63117062
Liver function test abnormal	58.57	9.82	482	370841	47699	63070000
Blood pressure systolic increased	57.61	9.82	119	371204	47278	63070421
Knee arthroplasty	57.09	9.82	147	371176	54059	63063640
Neutropenic sepsis	56.64	9.82	218	371105	16220	63101479
Pregnancy	56.21	9.82	80	371243	36756	63080943
Syncope	55.78	9.82	981	370342	116404	63001295
Gastric polyps	55.39	9.82	83	371240	3322	63114377
Sepsis	55.38	9.82	1228	370095	151895	62965804
General physical health deterioration	54.07	9.82	840	370483	200562	62917137
Toxic epidermal necrolysis	53.61	9.82	291	371032	25043	63092656
Anaemia	53.27	9.82	2160	369163	291270	62826429
Live birth	53.22	9.82	43	371280	25587	63092112
Grip strength decreased	52.03	9.82	33	371290	22254	63095445
Tenosynovitis	51.95	9.82	9	371314	13786	63103913
Angioedema	51.58	9.82	467	370856	47498	63070201
Deep vein thrombosis postoperative	51.26	9.82	4	371319	11365	63106334
Bursitis	51.21	9.82	86	371237	36955	63080744
Tremor	51.18	9.82	1071	370252	131168	62986531
Serotonin syndrome	50.63	9.82	314	371009	28368	63089331
Dizziness	49.74	9.82	3029	368294	426896	62690803
Derealisation	49.13	9.82	47	371276	1161	63116538
Feeling of despair	48.43	9.82	64	371259	2275	63115424
Product use in unapproved indication	48.03	9.82	747	370576	178333	62939366
Depersonalisation/derealisation disorder	47.68	9.82	49	371274	1323	63116376
Urinary tract infection	47.24	9.82	1945	369378	262739	62854960
Lip dry	46.77	9.82	16	371307	15454	63102245
Peripheral swelling	46.39	9.82	1192	370131	264750	62852949
Joint range of motion decreased	46.03	9.82	74	371249	32354	63085345
Sensitisation	46.02	9.82	76	371247	3310	63114389
Hallucination	46.01	9.82	507	370816	54310	63063389
Muscle spasticity	45.96	9.82	36	371287	21758	63095941
Breast cancer stage III	45.87	9.82	4	371319	10382	63107317
Vision blurred	43.94	9.82	769	370554	91155	63026544
Blood pressure systolic abnormal	43.79	9.82	12	371311	13374	63104325
Infective pulmonary exacerbation of cystic fibrosis	43.65	9.82	132	371191	8685	63109014
Pulmonary malformation	43.25	9.82	25	371298	274	63117425
Gastritis	43.12	9.82	369	370954	36934	63080765
Inappropriate antidiuretic hormone secretion	43.00	9.82	192	371131	15270	63102429
Injury	42.72	9.82	252	371071	72995	63044704
Fatigue	42.49	9.82	4548	366775	883480	62234219
Prescribed underdose	41.91	9.82	68	371255	29621	63088078
Fibromyalgia	41.62	9.82	287	371036	80133	63037566
H1N1 influenza	41.40	9.82	51	371272	1688	63116011
Hypoglycaemia	41.38	9.82	535	370788	59530	63058169
Metabolic acidosis	40.69	9.82	423	370900	44646	63073053
Hallucinations, mixed	40.26	9.82	88	371235	4741	63112958
Dyspnoea	40.14	9.82	4435	366888	656878	62460821
Blood sodium decreased	40.02	9.82	261	371062	23991	63093708
Circulatory collapse	39.88	9.82	242	371081	21696	63096003
Product dose omission issue	39.80	9.82	1713	369610	232600	62885099
Atrial fibrillation	39.54	9.82	927	370396	115709	63001990
Hypophosphataemia	38.93	9.82	151	371172	11275	63106424
Osteoarthritis	38.85	9.82	363	370960	94980	63022719
Atrial tachycardia	38.50	9.82	80	371243	4160	63113539
Drug abuse	38.42	9.82	257	371066	72261	63045438
Upper gastrointestinal haemorrhage	38.19	9.82	214	371109	18638	63099061
Haemoglobin decreased	37.94	9.82	1117	370206	144368	62973331
Facet joint syndrome	37.66	9.82	12	371311	12126	63105573
Burning mouth syndrome	37.64	9.82	28	371295	483	63117216
Blood magnesium decreased	37.55	9.82	165	371158	13033	63104666
Swelling face	37.47	9.82	550	370773	62925	63054774
Rectal haemorrhage	37.34	9.82	445	370878	48585	63069114
Drug resistance	36.81	9.82	48	371275	22885	63094814
Ventricular tachycardia	36.70	9.82	221	371102	19758	63097941
Blood pressure fluctuation	36.55	9.82	143	371180	46174	63071525
Cardiospasm	36.17	9.82	50	371273	1857	63115842
X-ray abnormal	36.15	9.82	3	371320	8107	63109592
Therapeutic response decreased	35.70	9.82	212	371111	61313	63056386
Palmoplantar keratoderma	35.66	9.82	51	371272	1956	63115743
Cross sensitivity reaction	35.60	9.82	53	371270	2109	63115590
Mania	35.48	9.82	155	371168	12212	63105487
Malignant mediastinal neoplasm	35.39	9.82	43	371280	1403	63116296
Disturbance in attention	35.22	9.82	360	370963	37829	63079870
Muscle rigidity	35.20	9.82	147	371176	11353	63106346
Renal impairment	34.96	9.82	718	370605	87637	63030062
Renal disorder	34.92	9.82	320	371003	32654	63085045
Tinnitus	34.87	9.82	340	370983	35288	63082411
Blood pressure diastolic abnormal	34.68	9.82	21	371302	14521	63103178
Malignant neoplasm progression	34.61	9.82	310	371013	81811	63035888
Agitation	34.58	9.82	516	370807	59241	63058458
Flatulence	34.37	9.82	332	370991	34370	63083329
Palatal oedema	34.28	9.82	28	371295	557	63117142
Atrioventricular block first degree	34.25	9.82	107	371216	7166	63110533
Pruritus genital	33.98	9.82	58	371265	2596	63115103
Drug dispensed to wrong patient	33.96	9.82	22	371301	300	63117399
Pulmonary embolism	33.81	9.82	908	370415	115776	63001923
Bicytopenia	33.74	9.82	56	371267	2449	63115250
Confusional state	33.67	9.82	1698	369625	234682	62883017
Mouth swelling	33.58	9.82	81	371242	4659	63113040
Ventricular fibrillation	33.49	9.82	148	371175	11719	63105980
Muscle spasms	33.45	9.82	1171	370152	154979	62962720
Torus fracture	33.13	9.82	17	371306	144	63117555
Breast cancer stage II	32.25	9.82	6	371317	8730	63108969
Urinary retention	32.06	9.82	294	371029	30007	63087692
Nightmare	31.94	9.82	207	371116	18987	63098712
Drooling	31.69	9.82	70	371253	3798	63113901
Prescription drug used without a prescription	31.68	9.82	53	371270	2333	63115366
Ejection fraction	31.36	9.82	53	371270	2353	63115346
Acute generalised exanthematous pustulosis	31	9.82	138	371185	10961	63106738
Parosmia	30.80	9.82	93	371230	6113	63111586
Tachycardia	30.75	9.82	907	370416	117249	63000450
Nausea	30.64	9.82	5557	365766	848914	62268785
Clostridium difficile infection	30.49	9.82	288	371035	29634	63088065
Oesophagitis	30.16	9.82	170	371153	14838	63102861
Blood urea increased	29.99	9.82	260	371063	26119	63091580
Multiple drug therapy	29.90	9.82	66	371257	3580	63114119
Tension headache	29.89	9.82	82	371241	5104	63112595
Neutrophil count increased	29.84	9.82	182	371141	16345	63101354
Device difficult to use	29.80	9.82	19	371304	12777	63104922
Enthesopathy	29.57	9.82	7	371316	8607	63109092
Jaundice	29.54	9.82	281	371042	28970	63088729
Acidosis	29.39	9.82	137	371186	11096	63106603
Hypergammaglobulinaemia	28.58	9.82	24	371299	497	63117202
Dilatation intrahepatic duct acquired	28.49	9.82	27	371296	659	63117040
Adjustment disorder with depressed mood	28.43	9.82	12	371311	10192	63107507
Inflammation	28.29	9.82	326	370997	81947	63035752
Pulmonary toxicity	28.20	9.82	10	371313	9445	63108254
Adverse drug reaction	28.14	9.82	314	371009	79400	63038299
Pallor	28.12	9.82	288	371035	30280	63087419
Hypertensive nephropathy	27.72	9.82	26	371297	626	63117073
Dissociation	27.60	9.82	56	371267	2863	63114836
Respiratory tract malformation	27.55	9.82	16	371307	177	63117522
Asthenia	27.54	9.82	2603	368720	381001	62736698
Lower respiratory tract infection	27.52	9.82	577	370746	131730	62985969
Hepatitis acute	27.47	9.82	116	371207	9004	63108695
Abnormal loss of weight	27.16	9.82	85	371238	5697	63112002
Polycystic ovaries	27.08	9.82	72	371251	4399	63113300
Autoimmune disorder	26.51	9.82	37	371286	17140	63100559
Dysgeusia	26.50	9.82	402	370921	46308	63071391
Hypoaesthesia oral	26.43	9.82	148	371175	12885	63104814
Panniculitis	26.38	9.82	17	371306	11368	63106331
Peripheral venous disease	26.31	9.82	31	371292	15446	63102253
Limb reduction defect	26.26	9.82	21	371302	405	63117294
Congenital thrombocytopenia	26.23	9.82	11	371312	55	63117644
Accidental exposure to product	26.11	9.82	78	371245	27327	63090372
Melaena	26.01	9.82	282	371041	30083	63087616
Dislocation of vertebra	25.98	9.82	9	371314	8626	63109073
Maternal exposure timing unspecified	25.88	9.82	5	371318	7082	63110617
Feeling of body temperature change	25.84	9.82	75	371248	4822	63112877
Paraesthesia	25.84	9.82	1144	370179	155822	62961877
Lung cyst	25.67	9.82	19	371304	325	63117374
Transient ischaemic attack	25.47	9.82	335	370988	37418	63080281
Burning sensation	25.23	9.82	453	370870	53954	63063745
Adjusted calcium decreased	25.15	9.82	15	371308	175	63117524
Abdominal distension	25.08	9.82	674	370649	85941	63031758
Blood parathyroid hormone decreased	24.99	9.82	13	371310	9778	63107921
Tongue oedema	24.94	9.82	71	371252	4515	63113184
Stevens-Johnson syndrome	24.85	9.82	239	371084	24711	63092988
Musculoskeletal pain	24.69	9.82	385	370938	91892	63025807
Hyperhidrosis	24.68	9.82	815	370508	107021	63010678
Ventilation perfusion mismatch	24.65	9.82	22	371301	496	63117203
Drug reaction with eosinophilia and systemic symptoms	24.42	9.82	304	371019	33532	63084167
Nephroangiosclerosis	24.33	9.82	14	371309	152	63117547
Thrombocytopenia	24.30	9.82	1099	370224	150058	62967641
Hepatic encephalopathy	24.15	9.82	130	371193	11152	63106547
Hyperreflexia	24.08	9.82	83	371240	5851	63111848
Abdominal tenderness	23.92	9.82	103	371220	8063	63109636
Product substitution issue	23.91	9.82	168	371155	15828	63101871
Type I hypersensitivity	23.83	9.82	53	371270	2889	63114810
Abdominal pain upper	23.70	9.82	1454	369869	204990	62912709
Pulseless electrical activity	23.70	9.82	97	371226	7424	63110275
Sleep terror	23.68	9.82	50	371273	2630	63115069
Blood phosphorus increased	23.64	9.82	55	371268	3090	63114609
Product packaging confusion	23.50	9.82	14	371309	163	63117536
Blood alkaline phosphatase increased	23.31	9.82	367	370956	42600	63075099
Myalgia	23.26	9.82	1064	370259	145465	62972234
Long QT syndrome	23.19	9.82	56	371267	3223	63114476
Caesarean section	23.12	9.82	40	371283	16992	63100707
Cyanosis	23.10	9.82	174	371149	16761	63100938
Seizure	23.02	9.82	972	370351	131662	62986037
Compartment syndrome	23.01	9.82	45	371278	2239	63115460
Hypergastrinaemia	22.96	9.82	12	371311	106	63117593
Ejection fraction abnormal	22.84	9.82	39	371284	1746	63115953
Nephropathy	22.59	9.82	85	371238	6256	63111443
Muscle disorder	22.39	9.82	72	371251	4897	63112802
Hallucination, visual	22.35	9.82	191	371132	19107	63098592
Body temperature decreased	22.25	9.82	54	371269	20265	63097434
Blood pressure diastolic decreased	22.09	9.82	64	371259	22642	63095057
Carotid artery occlusion	22.05	9.82	69	371254	4625	63113074
Cholecystitis chronic	21.91	9.82	119	371204	10242	63107457
Obstructive airways disorder	21.89	9.82	56	371267	20643	63097056
Myelosuppression	21.50	9.82	69	371254	23634	63094065
Polyuria	21.49	9.82	103	371220	8439	63109260
Deformity	21.40	9.82	22	371301	11662	63106037
Blood immunoglobulin E increased	21.33	9.82	60	371263	3789	63113910
Bradycardia	21.25	9.82	570	370753	72657	63045042
Intestinal dilatation	21.22	9.82	37	371286	1685	63116014
Dry skin	21.11	9.82	458	370865	56429	63061270
Temperature regulation disorder	21.01	9.82	5	371318	6127	63111572
Unintentional medical device removal	20.93	9.82	5	371318	6110	63111589
Vertigo	20.91	9.82	478	370845	59409	63058290
Memory impairment	20.88	9.82	776	370547	103482	63014217
Chronic obstructive pulmonary disease	20.86	9.82	497	370826	62189	63055510
Calcium deficiency	20.82	9.82	29	371294	1085	63116614
Faeces discoloured	20.82	9.82	182	371141	18327	63099372
Impaired quality of life	20.75	9.82	145	371178	13638	63104061
Immunisation	20.73	9.82	30	371293	1163	63116536
Blood creatinine increased	20.64	9.82	666	370657	87178	63030521
Giardiasis	20.55	9.82	9	371314	51	63117648
Gastrointestinal stoma complication	20.48	9.82	38	371285	1817	63115882
Therapeutic product ineffective	20.45	9.82	37	371286	1735	63115964
Atrioventricular block complete	20.40	9.82	99	371224	8152	63109547
Electrolyte imbalance	20.34	9.82	193	371130	19883	63097816
Cholestasis	20.20	9.82	262	371061	29172	63088527
Facial pain	20.15	9.82	118	371205	10443	63107256
Duodenal stenosis	20.01	9.82	20	371303	522	63117177
Skin test positive	19.95	9.82	23	371300	709	63116990
Cutaneous lupus erythematosus	19.92	9.82	47	371276	2665	63115034
Disability	19.90	9.82	49	371274	18298	63099401
Injection site reaction	19.69	9.82	233	371090	58291	63059408
Heart rate decreased	19.62	9.82	171	371152	45389	63072310
Head discomfort	19.53	9.82	140	371183	13275	63104424
Sciatica	19.53	9.82	119	371204	34205	63083494
Breast cancer stage I	19.36	9.82	8	371315	6881	63110818
Torsade de pointes	19.25	9.82	139	371184	13212	63104487
Moraxella test positive	19.21	9.82	7	371316	22	63117677
Dementia	19.20	9.82	181	371142	18613	63099086
Exostosis	19.14	9.82	48	371275	17814	63099885
Dialysis	18.94	9.82	115	371208	10312	63107387
Product formulation issue	18.94	9.82	20	371303	558	63117141
Intravascular haemolysis	18.91	9.82	16	371307	335	63117364
Loss of personal independence in daily activities	18.59	9.82	430	370893	96860	63020839
Pneumonia	18.42	9.82	2990	368333	453777	62663922
Congenital ovarian anomaly	18.36	9.82	6	371317	12	63117687
Mood swings	18.27	9.82	175	371148	18073	63099626
Pulmonary fibrosis	18.24	9.82	147	371176	39662	63078037
Gastrointestinal erosion	18.23	9.82	21	371302	647	63117052
Hyperbilirubinaemia	18.20	9.82	121	371202	11193	63106506
Drug tolerance	18.08	9.82	9	371314	6940	63110759
Pneumonitis	18.04	9.82	298	371025	34924	63082775
Tongue blistering	18.02	9.82	33	371290	1562	63116137
Full blood count decreased	18.00	9.82	232	371091	25792	63091907
Gastrooesophageal reflux disease	18.00	9.82	707	370616	94932	63022767
Peritonitis bacterial	17.88	9.82	66	371257	4813	63112886
Pregnancy with contraceptive device	17.81	9.82	3	371320	4691	63113008
Respiratory failure	17.79	9.82	747	370576	101111	63016588
Insulin autoimmune syndrome	17.75	9.82	10	371313	104	63117595
Ear pain	17.66	9.82	131	371192	35987	63081712
Decreased appetite	17.61	9.82	1701	369622	249351	62868348
Talipes	17.58	9.82	32	371291	1508	63116191
Skin discolouration	17.55	9.82	315	371008	37513	63080186
Emotional disorder	17.43	9.82	136	371187	13243	63104456
Hepatitis cholestatic	17.35	9.82	83	371240	6795	63110904
Gallbladder adenocarcinoma	17.35	9.82	10	371313	109	63117590
Device use error	17.34	9.82	6	371317	5755	63111944
Hiatus hernia	17.33	9.82	198	371125	21396	63096303
Urine output increased	17.25	9.82	30	371293	1363	63116336
Drug eruption	17.11	9.82	98	371225	28596	63089103
Haemodialysis	17.10	9.82	100	371223	8847	63108852
Large intestine infection	17.04	9.82	36	371287	1894	63115805
Muscle twitching	17.00	9.82	183	371140	19485	63098214
Cystic fibrosis	16.93	9.82	50	371273	3246	63114453
Blood creatine phosphokinase increased	16.92	9.82	261	371062	30169	63087530
Genital ulceration	16.88	9.82	20	371303	635	63117064
Sensory loss	16.78	9.82	110	371213	10128	63107571
Maternal exposure before pregnancy	16.75	9.82	12	371311	7591	63110108
Pancytopenia	16.73	9.82	710	370613	96223	63021476
Suicide attempt	16.69	9.82	253	371070	60665	63057034
Catatonia	16.69	9.82	3	371320	4474	63113225
Acute psychosis	16.67	9.82	42	371281	2483	63115216
Limb hypoplasia congenital	16.63	9.82	12	371311	197	63117502
Chromaturia	16.58	9.82	160	371163	16557	63101142
Metastases to lymph nodes	16.55	9.82	14	371309	8144	63109555
Colitis	16.53	9.82	386	370937	48142	63069557
Hip fracture	16.46	9.82	253	371070	29221	63088478
Hypertonia	16.39	9.82	62	371261	4575	63113124
Joint stiffness	16.37	9.82	161	371162	41708	63075991
Deep vein thrombosis	16.36	9.82	622	370701	83178	63034521
C-reactive protein increased	16.34	9.82	425	370898	94282	63023417
Thermohypoaesthesia	16.32	9.82	10	371313	123	63117576
Dermatitis bullous	16.20	9.82	95	371228	8413	63109286
Injection site pain	16.19	9.82	608	370715	129192	62988507
Night sweats	16.17	9.82	195	371128	48619	63069080
Septic shock	16.13	9.82	507	370816	66122	63051577
Drug ineffective for unapproved indication	15.97	9.82	125	371198	33938	63083761
Oral pain	15.96	9.82	244	371079	28150	63089549
International normalised ratio abnormal	15.92	9.82	49	371274	3255	63114444
Drug clearance decreased	15.89	9.82	30	371293	1454	63116245
Drug level increased	15.86	9.82	203	371120	22533	63095166
Device dislocation	15.76	9.82	87	371236	25618	63092081
Appendicitis	15.74	9.82	92	371231	8137	63109562
Illness	15.73	9.82	387	370936	48672	63069027
Rebound acid hypersecretion	15.67	9.82	14	371309	316	63117383
Glomerular filtration rate decreased	15.55	9.82	133	371190	13308	63104391
Nephrectomy	15.55	9.82	30	371293	1478	63116221
Poisoning deliberate	15.55	9.82	26	371297	11192	63106507
Genital pain	15.48	9.82	16	371307	435	63117264
Fear of eating	15.47	9.82	15	371308	377	63117322
Renal arteriosclerosis	15.47	9.82	8	371315	69	63117630
Erythrodermic psoriasis	15.41	9.82	24	371299	994	63116705
Oedematous pancreatitis	15.41	9.82	18	371305	563	63117136
Respirovirus test positive	15.37	9.82	6	371317	24	63117675
Bezoar	15.30	9.82	30	371293	1496	63116203
Injection site bruising	15.22	9.82	164	371159	41746	63075953
Palpitations	15.20	9.82	806	370517	111964	63005735
Ulcer	15.12	9.82	90	371233	26017	63091682
Lactic acidosis	15.09	9.82	311	371012	37976	63079723
Parkinsonian rest tremor	15.09	9.82	9	371314	105	63117594
Multimorbidity	15.09	9.82	18	371305	576	63117123
Anticholinergic syndrome	15.08	9.82	39	371284	2343	63115356
Extrasystoles	15.05	9.82	65	371258	5095	63112604
Incontinence	15.02	9.82	118	371205	11514	63106185
Catarrh	14.98	9.82	30	371293	1519	63116180
Endocrine ophthalmopathy	14.89	9.82	19	371304	652	63117047
Blood potassium decreased	14.84	9.82	336	370987	41690	63076009
Wrong technique in product usage process	14.74	9.82	266	371057	62074	63055625
Sopor	14.72	9.82	73	371250	22091	63095608
Blast cells present	14.65	9.82	16	371307	464	63117235
Congenital oral malformation	14.49	9.82	11	371312	196	63117503
Hand-eye coordination impaired	14.47	9.82	6	371317	29	63117670
Dermatitis atopic	14.46	9.82	102	371221	9622	63108077
Aplastic anaemia	14.38	9.82	21	371302	9548	63108151
Hypertensive cardiomyopathy	14.16	9.82	11	371312	203	63117496
Endoscopy abnormal	14.14	9.82	5	371318	14	63117685
Bromhidrosis	14.14	9.82	5	371318	14	63117685
Feeling abnormal	14.14	9.82	1029	370294	147363	62970336
Cleft palate	14.14	9.82	23	371300	989	63116710
Symmetrical drug-related intertriginous and flexural exanthema	14.01	9.82	16	371307	488	63117211
Anosmia	13.98	9.82	78	371245	6782	63110917
Sepsis syndrome	13.97	9.82	22	371301	920	63116779
Wound infection	13.94	9.82	71	371252	21339	63096360
Urine chloride decreased	13.89	9.82	8	371315	87	63117612
Paraesthesia oral	13.89	9.82	173	371150	19083	63098616
Hypernatraemia	13.87	9.82	84	371239	7525	63110174
Aquagenic pruritus	13.85	9.82	6	371317	33	63117666
Skin necrosis	13.80	9.82	39	371284	13911	63103788
Derailment	13.77	9.82	7	371316	58	63117641
Lower limb fracture	13.77	9.82	84	371239	24137	63093562
Hypercholesterolaemia	13.75	9.82	71	371252	21263	63096436
False positive investigation result	13.73	9.82	18	371305	635	63117064
Cerebral haematoma	13.65	9.82	50	371273	3633	63114066
Dyskinesia	13.64	9.82	263	371060	31739	63085960
Superior mesenteric artery syndrome	13.59	9.82	8	371315	91	63117608
Potentiating drug interaction	13.58	9.82	56	371267	4300	63113399
Swelling of eyelid	13.56	9.82	45	371278	3111	63114588
Peripheral circulatory failure	13.52	9.82	22	371301	946	63116753
Lichen planus	13.51	9.82	37	371286	2301	63115398
Cerebrovascular arteriovenous malformation	13.44	9.82	8	371315	93	63117606
Genital blister	13.44	9.82	8	371315	93	63117606
Respiratory arrest	13.41	9.82	124	371199	32521	63085178
Stupor	13.36	9.82	55	371268	4220	63113479
Breast cancer female	13.35	9.82	38	371285	13521	63104178
Norovirus test positive	13.29	9.82	11	371312	223	63117476
Sputum retention	13.29	9.82	17	371306	585	63117114
Gamma-glutamyltransferase increased	13.27	9.82	276	371047	33755	63083944
Skin exfoliation	13.22	9.82	338	370985	42764	63074935
Sight disability	13.22	9.82	9	371314	134	63117565
Rash macular	13.22	9.82	201	371122	23163	63094536
Polyserositis	13.19	9.82	14	371309	393	63117306
Chronic spontaneous urticaria	13.15	9.82	24	371299	1133	63116566
Nikolsky's sign	13.15	9.82	8	371315	97	63117602
Poor peripheral circulation	13.14	9.82	50	371273	3699	63114000
Haemorrhage intracranial	13.10	9.82	128	371195	13291	63104408
Avian influenza	13.10	9.82	7	371316	65	63117634
Mouth ulceration	13.03	9.82	268	371055	32716	63084983
Cardiac steatosis	13.02	9.82	6	371317	39	63117660
Anal incontinence	13.01	9.82	129	371194	13447	63104252
Drug dose titration not performed	13.00	9.82	16	371307	529	63117170
Metastases to bone	12.96	9.82	71	371252	20948	63096751
Infective exacerbation of chronic obstructive airways disease	12.95	9.82	25	371298	1232	63116467
Gastrointestinal mucosal exfoliation	12.94	9.82	9	371314	139	63117560
Dysmorphism	12.93	9.82	36	371287	2260	63115439
Depression	12.85	9.82	1325	369998	195167	62922532
Dental discomfort	12.82	9.82	15	371308	470	63117229
Muscular weakness	12.80	9.82	855	370468	121498	62996201
Blindness	12.79	9.82	188	371135	21511	63096188
Urinary tract infection pseudomonal	12.76	9.82	20	371303	833	63116866
Abnormal weight gain	12.67	9.82	31	371292	1799	63115900
DNA antibody	12.65	9.82	6	371317	42	63117657
Lipidosis	12.65	9.82	6	371317	42	63117657
Soft tissue disorder	12.65	9.82	5	371318	4417	63113282
Hypervolaemia	12.62	9.82	235	371088	28178	63089521
Hair injury	12.62	9.82	5	371318	21	63117678
Salmonellosis	12.61	9.82	24	371299	1170	63116529
Pulmonary pain	12.61	9.82	47	371276	3443	63114256
Developmental hip dysplasia	12.59	9.82	26	371297	1346	63116353
Cholangitis	12.53	9.82	65	371258	5496	63112203
White blood cell count increased	12.42	9.82	372	370951	48189	63069510
Subarachnoid haemorrhage	12.39	9.82	133	371190	14150	63103549
Joint destruction	12.35	9.82	11	371312	6241	63111458
Dolichocolon	12.24	9.82	4	371319	8	63117691
Foot deformity	12.24	9.82	104	371219	27749	63089950
Injection site swelling	12.21	9.82	200	371123	47372	63070327
Amyloid arthropathy	12.21	9.82	16	371307	564	63117135
Obesity	12.21	9.82	114	371209	29838	63087861
Rash papular	12.17	9.82	143	371180	15559	63102140
Seronegative arthritis	12.13	9.82	4	371319	3955	63113744
Occult blood positive	12.10	9.82	48	371275	3622	63114077
Acinetobacter test positive	12.09	9.82	7	371316	77	63117622
Small intestinal obstruction	12.07	9.82	162	371161	18175	63099524
Eyelid retraction	11.98	9.82	6	371317	48	63117651
Herpes zoster	11.96	9.82	379	370944	82083	63035616
Tracheo-oesophageal fistula	11.95	9.82	16	371307	576	63117123
Hypertrichosis	11.95	9.82	23	371300	1131	63116568
Arthritis	11.92	9.82	555	370768	115366	63002333
Lung consolidation	11.91	9.82	52	371271	4096	63113603
Splenic injury	11.79	9.82	10	371313	210	63117489
Urine sodium decreased	11.77	9.82	9	371314	162	63117537
Labelled drug-drug interaction medication error	11.74	9.82	125	371198	13274	63104425
Full blood count abnormal	11.65	9.82	255	371068	31462	63086237
Disorganised speech	11.64	9.82	24	371299	1241	63116458
Goitre	11.63	9.82	67	371256	5894	63111805
Listless	11.60	9.82	40	371283	2820	63114879
Multiple-drug resistance	11.60	9.82	8	371315	5162	63112537
Rheumatoid lung	11.60	9.82	4	371319	3844	63113855
Toxic shock syndrome	11.58	9.82	19	371304	823	63116876
Poliomyelitis	11.58	9.82	6	371317	52	63117647
Road traffic accident	11.51	9.82	148	371175	36484	63081215
Cholecystectomy	11.50	9.82	104	371219	10573	63107126
Intestinal ischaemia	11.50	9.82	79	371244	7389	63110310
Lipase increased	11.47	9.82	98	371225	9802	63107897
Cholecystitis	11.46	9.82	139	371184	15238	63102461
Second primary malignancy	11.43	9.82	18	371305	7935	63109764
Oesophageal adenocarcinoma	11.41	9.82	9	371314	170	63117529
Cytokine release syndrome	11.38	9.82	131	371192	14183	63103516
Pain of skin	11.37	9.82	111	371212	11523	63106176
Clostridium difficile colitis	11.27	9.82	176	371147	20393	63097306
Reduced facial expression	11.24	9.82	31	371292	1935	63115764
Pharyngeal swelling	11.23	9.82	70	371253	6334	63111365
Intestinal obstruction	11.21	9.82	248	371075	30651	63087048
Enzyme induction	11.20	9.82	6	371317	56	63117643
Premature delivery	11.19	9.82	118	371205	30163	63087536
Vulvar basal cell carcinoma	11.18	9.82	5	371318	30	63117669
Myxofibrosarcoma	11.16	9.82	7	371316	90	63117609
Postresuscitation encephalopathy	11.12	9.82	4	371319	12	63117687
Urticaria vesiculosa	11.12	9.82	4	371319	12	63117687
Genital neoplasm malignant female	11.11	9.82	8	371315	131	63117568
Restless legs syndrome	11.10	9.82	161	371162	18370	63099329
Coma	11.06	9.82	289	371034	64075	63053624
Extensor plantar response	11.05	9.82	24	371299	1287	63116412
Cholestasis of pregnancy	10.99	9.82	23	371300	1202	63116497
Carpal tunnel syndrome	10.98	9.82	177	371146	20640	63097059
Pituitary tumour benign	10.96	9.82	31	371292	1964	63115735
Urine output decreased	10.88	9.82	108	371215	11262	63106437
Acidosis hyperchloraemic	10.87	9.82	13	371310	417	63117282
Abnormal behaviour	10.87	9.82	181	371142	21245	63096454
Lymphangioleiomyomatosis	10.86	9.82	9	371314	183	63117516
Acquired cystic kidney disease	10.85	9.82	6	371317	60	63117639
Peptic ulcer perforation	10.81	9.82	9	371314	184	63117515
Diplopia	10.80	9.82	197	371126	23531	63094168
Bladder irritation	10.79	9.82	10	371313	237	63117462
Tangentiality	10.79	9.82	5	371318	33	63117666
Aphasia	10.78	9.82	261	371062	32739	63084960
Secondary adrenocortical insufficiency	10.76	9.82	25	371298	1403	63116296
Stoma site infection	10.73	9.82	18	371305	794	63116905
Beta haemolytic streptococcal infection	10.67	9.82	31	371292	1994	63115705
Ear, nose and throat examination abnormal	10.66	9.82	4	371319	14	63117685
Truncus coeliacus thrombosis	10.66	9.82	4	371319	14	63117685
Viral diarrhoea	10.65	9.82	9	371314	188	63117511
Foetal death	10.64	9.82	31	371292	10949	63106750
Supraventricular tachycardia	10.63	9.82	129	371194	14142	63103557
Thinking abnormal	10.62	9.82	102	371221	10541	63107158
Chest pain	10.61	9.82	1430	369893	214529	62903170
Anal haemorrhage	10.59	9.82	32	371291	2104	63115595
Poor sucking reflex	10.59	9.82	11	371312	301	63117398
Oroantral fistula	10.57	9.82	9	371314	190	63117509
Incorrect route of product administration	10.55	9.82	106	371217	27346	63090353
Mental status changes postoperative	10.53	9.82	9	371314	191	63117508
Pyogenic granuloma	10.53	9.82	11	371312	303	63117396
Central nervous system injury	10.51	9.82	8	371315	143	63117556
Hypophagia	10.45	9.82	248	371075	31011	63086688
Coeliac disease	10.42	9.82	39	371284	12758	63104941
Hyperaemia	10.42	9.82	33	371290	2226	63115473
Occupational problem environmental	10.38	9.82	3	371320	3	63117696
Biliary tract operation	10.38	9.82	3	371320	3	63117696
Pulmonary interstitial emphysema syndrome	10.38	9.82	3	371320	3	63117696
Speech disorder	10.32	9.82	311	371012	40318	63077381
Blood urea nitrogen/creatinine ratio decreased	10.31	9.82	5	371318	37	63117662
Choluria	10.30	9.82	9	371314	197	63117502
Product taste abnormal	10.28	9.82	31	371292	2036	63115663
Back pain	10.27	9.82	1726	369597	262419	62855280
Body height decreased	10.27	9.82	97	371226	9981	63107718
Formication	10.26	9.82	51	371272	4240	63113459
Intraductal papillary breast neoplasm	10.25	9.82	4	371319	16	63117683
Pyonephrosis	10.25	9.82	4	371319	16	63117683
Tuberculosis liver	10.25	9.82	4	371319	16	63117683
Faecal calprotectin increased	10.24	9.82	3	371320	3200	63114499
Pancreatic enzymes increased	10.22	9.82	17	371306	745	63116954
Product administration error	10.21	9.82	186	371137	22211	63095488
Lactation disorder	10.21	9.82	12	371311	378	63117321
Hyperchloraemia	10.20	9.82	17	371306	746	63116953
Rapid eye movement sleep behaviour disorder	10.19	9.82	11	371312	315	63117384
Burns second degree	10.16	9.82	30	371293	1948	63115751
Product odour abnormal	10.11	9.82	23	371300	1273	63116426
Eczema eyelids	10.10	9.82	8	371315	152	63117547
Gallbladder empyema	10.09	9.82	5	371318	39	63117660
Multiple organ dysfunction syndrome	10.09	9.82	417	370906	56335	63061364
Normal newborn	10.08	9.82	21	371302	8320	63109379
Presyncope	10.08	9.82	223	371100	27562	63090137
Biliary dyskinesia	10.07	9.82	37	371286	2692	63115007
Lung disorder	10.06	9.82	282	371041	61979	63055720
Gastric mucosal hypertrophy	10.06	9.82	6	371317	70	63117629
Blood phosphorus decreased	10.00	9.82	52	371271	4401	63113298
Shunt thrombosis	9.99	9.82	6	371317	71	63117628
Immunosuppressant drug level increased	9.98	9.82	45	371278	3593	63114106
Vitamin B12 deficiency	9.96	9.82	59	371264	5244	63112455
Bradykinesia	9.92	9.82	58	371265	5130	63112569
Rash erythematous	9.90	9.82	322	371001	42188	63075511
Hepatic failure	9.90	9.82	276	371047	35380	63082319
Sudden death	9.87	9.82	99	371224	10350	63107349
Myositis	9.85	9.82	90	371233	9176	63108523
Ovarian germ cell cancer stage II	9.85	9.82	6	371317	73	63117626
Injection site erythema	9.84	9.82	392	370931	82782	63034917
Therapeutic response shortened	9.83	9.82	36	371287	11852	63105847
Differential white blood cell count abnormal	9.83	9.82	17	371306	769	63116930

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypomagnesaemia	596.42	10.61	778	262242	21073	34672838
Off label use	310.18	10.61	1871	261149	417653	34276258
Drug abuse	281.68	10.61	201	262819	98895	34595016
Hypocalcaemia	279.86	10.61	586	262434	23703	34670208
Drug ineffective	260.56	10.61	2195	260825	454556	34239355
Tubulointerstitial nephritis	223.54	10.61	491	262529	20533	34673378
Chronic kidney disease	204.61	10.61	729	262291	40481	34653430
Acute kidney injury	159.40	10.61	3197	259823	301791	34392120
Drug interaction	132.03	10.61	2410	260610	223536	34470375
Toxicity to various agents	114.41	10.61	961	262059	199401	34494510
Treatment failure	99.35	10.61	123	262897	46574	34647337
Completed suicide	95.99	10.61	396	262624	97772	34596139
Therapeutic product effect incomplete	95.58	10.61	145	262875	50396	34643515
Product use in unapproved indication	93.78	10.61	510	262510	116989	34576922
Lower respiratory tract infection	92.70	10.61	477	262543	31160	34662751
Tetany	82.26	10.61	60	262960	766	34693145
Hyponatraemia	76.16	10.61	954	262066	81737	34612174
Lip swelling	75.15	10.61	279	262741	15801	34678110
Drug intolerance	66.87	10.61	227	262793	59343	34634568
Death	66.16	10.61	2391	260629	395658	34298253
Subacute cutaneous lupus erythematosus	65.85	10.61	57	262963	945	34692966
Inappropriate antidiuretic hormone secretion	65.31	10.61	228	262792	12525	34681386
Renal tubular acidosis	63.90	10.61	83	262937	2236	34691675
Drug resistance	63.20	10.61	61	262959	25866	34668045
Hypoparathyroidism	62.65	10.61	45	262975	560	34693351
Cardiospasm	62.20	10.61	68	262952	1520	34692391
Renal injury	61.59	10.61	205	262815	10990	34682921
Palmoplantar keratoderma	60.33	10.61	74	262946	1879	34692032
Hypertrichosis	60.25	10.61	38	262982	375	34693536
Drug dependence	56.71	10.61	59	262961	24158	34669753
Foetal exposure during pregnancy	55.52	10.61	128	262892	37973	34655938
Weight increased	54.91	10.61	442	262578	92591	34601320
Synovitis	54.22	10.61	19	263001	14047	34679864
C-reactive protein abnormal	53.29	10.61	3	263017	8707	34685204
Drug hypersensitivity	52.54	10.61	372	262648	80157	34613754
End stage renal disease	52.12	10.61	166	262854	8695	34685216
Diarrhoea	51.52	10.61	3497	259523	386415	34307496
Pruritus genital	44.54	10.61	68	262952	2136	34691775
Abdominal pain upper	43.14	10.61	767	262253	70723	34623188
Suicide attempt	42.58	10.61	151	262869	38965	34654946
Intentional product use issue	42.16	10.61	270	262750	59546	34634365
Hypokalaemia	41.94	10.61	643	262377	57571	34636340
Tension headache	41.76	10.61	79	262941	2963	34690948
Anosmia	41.65	10.61	93	262927	3931	34689980
Product use issue	40.75	10.61	293	262727	62923	34630988
Sleep terror	40.62	10.61	67	262953	2251	34691660
Loss of personal independence in daily activities	40.32	10.61	122	262898	33057	34660854
Immunisation	40.25	10.61	45	262975	1032	34692879
Myalgia	39.21	10.61	868	262152	83242	34610669
Therapy partial responder	38.80	10.61	12	263008	9604	34684307
Infusion related reaction	38.16	10.61	238	262782	52819	34641092
Renal failure	37.91	10.61	1267	261753	129290	34564621
Hypoparathyroidism secondary	37.89	10.61	20	263000	136	34693775
Facial pain	37.66	10.61	85	262935	3619	34690292
Blood pressure increased	37.51	10.61	453	262567	87649	34606262
Chromaturia	37.15	10.61	211	262809	14309	34679602
Immune reconstitution inflammatory syndrome	37.05	10.61	10	263010	8749	34685162
Gastric mucosal hypertrophy	36.88	10.61	19	263001	122	34693789
General physical health deterioration	36.36	10.61	713	262307	127556	34566355
Plasma cell myeloma	35.32	10.61	477	262543	41560	34652351
Atrial tachycardia	35.24	10.61	82	262938	3563	34690348
Blood pressure systolic increased	35.16	10.61	75	262945	22877	34671034
Labelled drug-drug interaction medication error	34.94	10.61	212	262808	14727	34679184
Condition aggravated	34.66	10.61	1142	261878	191054	34502857
Blood pressure fluctuation	34.28	10.61	88	262932	25161	34668750
Confusional state	33.83	10.61	1366	261654	142794	34551117
Malignant neoplasm progression	32.96	10.61	465	262555	87581	34606330
Heart rate decreased	32.94	10.61	125	262895	31620	34662291
Metabolic acidosis	32.44	10.61	485	262535	43195	34650716
Rheumatoid arthritis	31.00	10.61	165	262855	38073	34655838
Drug level increased	30.69	10.61	277	262743	21819	34672092
Hyperparathyroidism secondary	29.77	10.61	47	262973	1521	34692390
Neutrophil count increased	29.74	10.61	226	262794	16920	34676991
Poisoning	29.52	10.61	29	262991	12197	34681714
Oesophageal perforation	28.59	10.61	40	262980	1159	34692752
Immunosuppressant drug level increased	28.24	10.61	105	262915	5950	34687961
Inappropriate schedule of product administration	28.18	10.61	316	262704	61980	34631931
Multimorbidity	27.98	10.61	35	262985	907	34693004
Lethargy	26.90	10.61	447	262573	40675	34653236
Respiratory arrest	26.83	10.61	114	262906	27929	34665982
Gastric polyps	26.45	10.61	39	262981	1187	34692724
Blood magnesium decreased	26.38	10.61	107	262913	6316	34687595
Swollen tongue	26.17	10.61	194	262826	14411	34679500
Right hemisphere deficit syndrome	26	10.61	9	263011	16	34693895
Soft tissue mass	25.81	10.61	35	262985	984	34692927
Jejunal ulcer perforation	25.55	10.61	13	263007	81	34693830
Drug ineffective for unapproved indication	25.51	10.61	92	262928	23623	34670288
Myelosuppression	25.49	10.61	68	262952	19197	34674714
Interstitial lung disease	25.42	10.61	342	262678	64940	34628971
Infective pulmonary exacerbation of cystic fibrosis	25.36	10.61	110	262910	6691	34687220
Coronary artery disease	25.14	10.61	237	262783	48068	34645843
Product formulation issue	25.14	10.61	26	262994	544	34693367
Carotid artery occlusion	24.77	10.61	73	262947	3664	34690247
Gastrooesophageal reflux disease	24.71	10.61	412	262608	37512	34656399
Pathogen resistance	24.67	10.61	21	262999	9461	34684450
Muscle twitching	24.63	10.61	147	262873	10151	34683760
Pain of skin	24.48	10.61	101	262919	6008	34687903
Meconium abnormal	24.23	10.61	12	263008	70	34693841
Neutropenic sepsis	24.18	10.61	182	262838	13585	34680326
Venoocclusive liver disease	24.16	10.61	15	263005	7951	34685960
Multiple-drug resistance	24.10	10.61	5	263015	5234	34688677
Premature baby	23.99	10.61	72	262948	19561	34674350
Angioedema	23.98	10.61	405	262615	36969	34656942
Therapeutic product effect decreased	23.88	10.61	158	262862	34585	34659326
Substance abuse	23.72	10.61	14	263006	7627	34686284
Upper gastrointestinal haemorrhage	23.72	10.61	295	262725	25223	34668688
Abdominal pain	23.56	10.61	1479	261541	162139	34531772
Abnormal loss of weight	23.49	10.61	76	262944	4014	34689897
Blood pressure diastolic abnormal	23.44	10.61	4	263016	4814	34689097
Therapy non-responder	23.06	10.61	186	262834	38960	34654951
Mucormycosis	22.95	10.61	8	263012	5934	34687977
Hyperchlorhydria	22.81	10.61	27	262993	660	34693251
Renal impairment	22.71	10.61	898	262122	93615	34600296
Lymphoma	22.57	10.61	37	262983	12470	34681441
Respiratory tract infection	22.42	10.61	237	262783	19475	34674436
Overdose	22.34	10.61	518	262502	90541	34603370
Hallucination	21.98	10.61	525	262495	50973	34642938
Occupational dermatitis	21.87	10.61	12	263008	89	34693822
Gastritis	21.70	10.61	256	262764	21617	34672294
Tinnitus	21.55	10.61	239	262781	19879	34674032
Appendicolith	21.23	10.61	20	263000	8581	34685330
Vomiting	21.19	10.61	2150	260870	245471	34448440
Renal cyst haemorrhage	21.02	10.61	25	262995	614	34693297
Rectal prolapse	20.91	10.61	22	262998	470	34693441
Eye pruritus	20.61	10.61	111	262909	7378	34686533
Nephrogenic anaemia	20.57	10.61	49	262971	2162	34691749
Degenerative mitral valve disease	20.50	10.61	17	263003	265	34693646
Granuloma annulare	20.41	10.61	14	263006	161	34693750
Tetanus	20.38	10.61	10	263010	57	34693854
Nephritis	20.35	10.61	52	262968	2399	34691512
Hepatic encephalopathy	20.34	10.61	184	262836	14501	34679410
Haemophagocytic lymphohistiocytosis	20.20	10.61	42	262978	12931	34680980
Blood pressure systolic abnormal	19.83	10.61	3	263017	3945	34689966
Tenosynovitis	19.75	10.61	5	263015	4565	34689346
Palpitations	19.69	10.61	416	262604	39570	34654341
Exposure during pregnancy	19.56	10.61	23	262997	8911	34685000
Intraductal papillary mucinous neoplasm	19.39	10.61	22	262998	513	34693398
Lupus endocarditis	19.27	10.61	6	263014	6	34693905
Rectal haemorrhage	19.26	10.61	417	262603	39832	34654079
Cerebral atrophy congenital	18.94	10.61	10	263010	68	34693843
Swelling face	18.92	10.61	261	262759	22844	34671067
Therapeutic response decreased	18.81	10.61	136	262884	29177	34664734
Electrolyte imbalance	18.67	10.61	178	262842	14234	34679677
Type I hypersensitivity	18.66	10.61	35	262985	1304	34692607
Hypochromasia	18.59	10.61	17	263003	304	34693607
Sleep disorder due to a general medical condition	18.55	10.61	8	263012	5213	34688698
Intercepted product preparation error	18.54	10.61	4	263016	4074	34689837
Choluria	18.49	10.61	13	263007	156	34693755
Nicotine dependence	18.42	10.61	23	262997	595	34693316
Gastrointestinal haemorrhage	18.40	10.61	828	262192	87649	34606262
Aplastic anaemia	18.24	10.61	28	262992	9688	34684223
Rales	18.12	10.61	132	262888	9751	34684160
Eye injury	18.07	10.61	27	262993	832	34693079
Intentional overdose	18.03	10.61	226	262794	43448	34650463
Musculoskeletal stiffness	18.01	10.61	245	262775	46435	34647476
Alveolitis	17.92	10.61	40	262980	1690	34692221
Chemotherapeutic drug level increased	17.66	10.61	14	263006	204	34693707
Blood calcium decreased	17.53	10.61	133	262887	9951	34683960
Coma	17.53	10.61	240	262780	45438	34648473
Progressive multifocal leukoencephalopathy	17.51	10.61	29	262991	9735	34684176
Obstructive airways disorder	17.40	10.61	59	262961	15435	34678476
Cardiogenic shock	17.32	10.61	123	262897	26495	34667416
Malaise	17.28	10.61	1623	261397	184202	34509709
Liver function test abnormal	17.20	10.61	329	262691	30745	34663166
Myoclonic dystonia	17.19	10.61	9	263011	60	34693851
Full blood count abnormal	17.18	10.61	77	262943	18591	34675320
Indifference	17.07	10.61	12	263008	144	34693767
Malignant spinal cord compression	17.00	10.61	12	263008	145	34693766
Haematotoxicity	16.99	10.61	22	262998	8172	34685739
Macrocephaly	16.92	10.61	20	263000	488	34693423
Posthaemorrhagic hydrocephalus	16.91	10.61	11	263009	115	34693796
Cytomegalovirus infection	16.90	10.61	121	262899	26014	34667897
Urine calcium decreased	16.88	10.61	6	263014	12	34693899
Blood creatinine increased	16.84	10.61	875	262145	94101	34599810
Steatorrhoea	16.56	10.61	24	262996	719	34693192
Dry skin	16.55	10.61	329	262691	30958	34662953
Cerebral infarction	16.38	10.61	130	262890	27325	34666586
Febrile neutropenia	16.36	10.61	852	262168	135997	34557914
Post transplant lymphoproliferative disorder	16.33	10.61	15	263005	6513	34687398
Pyloric stenosis	16.32	10.61	26	262994	848	34693063
Bladder cancer	16.30	10.61	65	262955	16213	34677698
Helicobacter test positive	16.30	10.61	26	262994	849	34693062
Iron deficiency anaemia	16.18	10.61	133	262887	10196	34683715
Pseudoporphyria	16.09	10.61	17	263003	365	34693546
Gastric xanthoma	16.06	10.61	5	263015	5	34693906
Aggression	15.94	10.61	202	262818	38762	34655149
Sopor	15.93	10.61	43	262977	12093	34681818
Vena cava injury	15.89	10.61	16	263004	324	34693587
Body temperature decreased	15.78	10.61	48	262972	12986	34680925
Posterior reversible encephalopathy syndrome	15.69	10.61	32	262988	9922	34683989
Ventricular hyperkinesia	15.66	10.61	13	263007	203	34693708
Abdominal sepsis	15.62	10.61	28	262992	1007	34692904
Intestinal infarction	15.50	10.61	20	263000	535	34693376
Mesenteric vein thrombosis	15.50	10.61	25	262995	824	34693087
Incorrect dose administered	15.50	10.61	213	262807	40302	34653609
Hyperkalaemia	15.22	10.61	653	262367	68736	34625175
Dizziness	15.20	10.61	1872	261148	216649	34477262
Psoriatic arthropathy	15.18	10.61	87	262933	19711	34674200
Device malfunction	15.18	10.61	35	262985	10386	34683525
Jaundice	15.15	10.61	330	262690	31552	34662359
Gastric pH decreased	15.07	10.61	12	263008	176	34693735
Blood copper increased	14.96	10.61	6	263014	19	34693892
Migraine	14.95	10.61	199	262821	17279	34676632
Herpes simplex	14.85	10.61	12	263008	5547	34688364
Ventricular flutter	14.78	10.61	9	263011	83	34693828
Urinary tract infection	14.77	10.61	774	262246	83307	34610604
International normalised ratio increased	14.67	10.61	463	262557	46864	34647047
SARS-CoV-2 antibody test positive	14.63	10.61	17	263003	407	34693504
Stoma site haemorrhage	14.63	10.61	25	262995	865	34693046
Blood chromogranin A increased	14.58	10.61	14	263006	267	34693644
Vascular compression	14.55	10.61	16	263004	360	34693551
Bone erosion	14.51	10.61	6	263014	4009	34689902
Blood pressure diastolic increased	14.51	10.61	10	263010	5015	34688896
Visceral pain	14.51	10.61	8	263012	60	34693851
Gastroenteritis	14.48	10.61	169	262851	14231	34679680
Oropharyngeal blistering	14.47	10.61	12	263008	187	34693724
Polymyositis	14.39	10.61	33	262987	1420	34692491
Vasculitis	14.37	10.61	139	262881	11157	34682754
Rash papular	14.35	10.61	129	262891	10149	34683762
Vascular anastomotic haemorrhage	14.33	10.61	14	263006	273	34693638
Myocardial infarction	14.25	10.61	755	262265	120330	34573581
Disease progression	14.25	10.61	666	262354	107411	34586500
Pancreatic pseudocyst	14.20	10.61	24	262996	823	34693088
Ischaemic stroke	14.08	10.61	204	262816	18046	34675865
Blood pH abnormal	14.07	10.61	5	263015	10	34693901
Necrotising enterocolitis neonatal	14.06	10.61	13	263007	236	34693675
Somatosensory evoked potentials abnormal	13.89	10.61	11	263009	160	34693751
Lipodystrophy acquired	13.81	10.61	4	263016	3340	34690571
Oxygen saturation decreased	13.80	10.61	304	262716	53514	34640397
Agitated depression	13.79	10.61	13	263007	242	34693669
Ageusia	13.69	10.61	128	262892	10180	34683731
Accidental exposure to product	13.54	10.61	50	262970	12752	34681159
Acute interstitial pneumonitis	13.52	10.61	17	263003	443	34693468
Wrong technique in product usage process	13.47	10.61	190	262830	35796	34658115
Antipsychotic drug level decreased	13.45	10.61	26	262994	991	34692920
Right atrial enlargement	13.45	10.61	13	263007	250	34693661
Arteriosclerotic gangrene	13.39	10.61	8	263012	71	34693840
Breast inflammation	13.36	10.61	6	263014	27	34693884
Rheumatoid nodule	13.17	10.61	3	263017	2944	34690967
Rebound acid hypersecretion	13.09	10.61	9	263011	104	34693807
Dermatitis infected	13.09	10.61	9	263011	104	34693807
Perineal cyst	13.08	10.61	13	263007	259	34693652
Induration	12.99	10.61	25	262995	950	34692961
Superinfection	12.87	10.61	45	262975	2474	34691437
Pancreatic abscess	12.85	10.61	8	263012	77	34693834
Latent tetany	12.85	10.61	4	263016	4	34693907
Aspartate aminotransferase increased	12.85	10.61	400	262620	67383	34626528
COVID-19 treatment	12.84	10.61	13	263007	265	34693646
Abdominal wall haemorrhage	12.67	10.61	17	263003	473	34693438
Ectopic gastric mucosa	12.67	10.61	5	263015	15	34693896
Dysmorphism	12.62	10.61	4	263016	3152	34690759
Coronary artery bypass	12.58	10.61	11	263009	4891	34689020
Retinopathy hypertensive	12.50	10.61	13	263007	274	34693637
Epstein-Barr virus infection	12.47	10.61	24	262996	7604	34686307
Asthma	12.40	10.61	236	262784	42420	34651491
Blood gastrin increased	12.40	10.61	6	263014	33	34693878
Aminoaciduria	12.38	10.61	13	263007	277	34693634
Pneumocystis jirovecii pneumonia	12.38	10.61	92	262928	19618	34674293
Oropharyngeal swelling	12.32	10.61	17	263003	486	34693425
Blister	12.30	10.61	241	262779	22617	34671294
Mitral valve thickening	12.29	10.61	15	263005	379	34693532
Incision site pain	12.27	10.61	36	262984	1802	34692109
Prostate cancer	12.27	10.61	217	262803	39432	34654479
Brain scan abnormal	12.26	10.61	23	262997	857	34693054
Hepatitis B reactivation	12.26	10.61	7	263013	3884	34690027
Product substitution issue	12.25	10.61	123	262897	9972	34683939
Gastroenteritis eosinophilic	12.25	10.61	11	263009	192	34693719
Lymphangitis	12.23	10.61	18	263002	547	34693364
Coronary arterial stent insertion	12.21	10.61	8	263012	4121	34689790
Oesophagitis	12.19	10.61	153	262867	13108	34680803
Calciphylaxis	12.17	10.61	26	262994	1066	34692845
Faeces discoloured	12.15	10.61	168	262852	14710	34679201
Blood sodium increased	12.14	10.61	48	262972	2800	34691111
Hypocalcaemic seizure	12.12	10.61	6	263014	35	34693876
Hepatic enzyme abnormal	12.10	10.61	47	262973	2719	34691192
Neuroleptic malignant syndrome	12.10	10.61	82	262938	17852	34676059
Urinary tract discomfort	12.08	10.61	9	263011	119	34693792
Carotid arteriosclerosis	12.03	10.61	36	262984	1822	34692089
Diverticulum intestinal	12.03	10.61	61	262959	3960	34689951
Muscular weakness	12.00	10.61	667	262353	72230	34621681
Red blood cell analysis abnormal	11.99	10.61	5	263015	18	34693893
Sexual dysfunction	11.99	10.61	18	263002	6285	34687626
Low birth weight baby	11.97	10.61	26	262994	7879	34686032
Aortic dilatation	11.92	10.61	30	262990	1371	34692540
Rhabdomyolysis	11.88	10.61	627	262393	67536	34626375
Systemic infection	11.86	10.61	13	263007	5199	34688712
Lip ulceration	11.86	10.61	21	262999	748	34693163
Hepatic haematoma	11.81	10.61	15	263005	395	34693516
Gastric ischaemia	11.79	10.61	5	263015	19	34693892
Product package associated injury	11.69	10.61	3	263017	0	34693911
Discoloured vomit	11.69	10.61	17	263003	511	34693400
High-grade B-cell lymphoma	11.65	10.61	9	263011	126	34693785
Congenital oesophageal anomaly	11.59	10.61	8	263012	93	34693818
Postictal paralysis	11.57	10.61	12	263008	252	34693659
Dysgeusia	11.57	10.61	271	262749	26226	34667685
Endophthalmitis	11.51	10.61	6	263014	3502	34690409
Product monitoring error	11.43	10.61	64	262956	4317	34689594
Transaminases increased	11.37	10.61	138	262882	26685	34667226
Viral mutation identified	11.37	10.61	4	263016	2950	34690961
Subarachnoid haemorrhage	11.28	10.61	145	262875	12490	34681421
Postictal state	11.27	10.61	22	262998	845	34693066
Joint swelling	11.21	10.61	354	262666	59536	34634375
Muscle contractions involuntary	11.12	10.61	35	262985	1821	34692090
Graft versus host disease in gastrointestinal tract	11.08	10.61	7	263013	3676	34690235
Pharyngeal dystonia	11.02	10.61	7	263013	70	34693841
Zinc deficiency	10.99	10.61	6	263014	44	34693867
Pericarditis	10.98	10.61	135	262885	11510	34682401
Cholelithiasis obstructive	10.94	10.61	4	263016	9	34693902
Bronchopulmonary aspergillosis	10.93	10.61	65	262955	14594	34679317
Drug tolerance	10.92	10.61	4	263016	2878	34691033
Amino acid level increased	10.92	10.61	15	263005	427	34693484
Hypophosphataemia	10.91	10.61	129	262891	10897	34683014
Amyloidosis	10.91	10.61	38	262982	2085	34691826
Euphoric mood	10.84	10.61	16	263004	5625	34688286
Lacrimal disorder	10.82	10.61	13	263007	323	34693588
Cytomegalovirus viraemia	10.79	10.61	25	262995	7405	34686506
Hernial eventration	10.78	10.61	7	263013	73	34693838
Delayed graft function	10.76	10.61	39	262981	2182	34691729
Stress	10.74	10.61	162	262858	30185	34663726
Ischaemic nephropathy	10.72	10.61	5	263015	25	34693886
Nasopharyngitis	10.71	10.61	424	262596	69544	34624367
Colorectal cancer	10.70	10.61	12	263008	4749	34689162
Incision site cellulitis	10.65	10.61	4	263016	10	34693901
Radiation inflammation	10.61	10.61	22	262998	883	34693028

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypomagnesaemia	1293.74	9.64	1567	521175	45344	79176302
Synovitis	744.31	9.64	66	522676	150668	79070978
Drug ineffective	735.29	9.64	4129	518613	1076784	78144862
Drug interaction	733.09	9.64	4943	517799	410240	78811406
Drug intolerance	702.65	9.64	431	522311	263688	78957958
Tubulointerstitial nephritis	651.61	9.64	1012	521730	37223	79184423
Acute kidney injury	649.57	9.64	5705	517037	513699	78707947
Hypocalcaemia	591.99	9.64	1125	521617	48799	79172847
Pemphigus	574.15	9.64	17	522725	99565	79122081
Hand deformity	567.47	9.64	27	522715	103892	79117754
Hyponatraemia	547.39	9.64	2464	520278	175384	79046262
Anti-cyclic citrullinated peptide antibody positive	521.64	9.64	4	522738	83139	79138507
Treatment failure	513.76	9.64	237	522505	170249	79051397
Contraindicated product administered	453.40	9.64	233	522509	157305	79064341
Off label use	422.84	9.64	3860	518882	903355	78318291
Wound	405.69	9.64	128	522614	116051	79105595
Therapeutic product effect decreased	403.71	9.64	291	522451	163572	79058074
Rheumatoid factor positive	365.59	9.64	5	522737	59834	79161812
Systemic lupus erythematosus	365.58	9.64	168	522574	120981	79100665
Drug hypersensitivity	361.87	9.64	898	521844	298018	78923628
Arthropathy	352.72	9.64	384	522358	176727	79044919
Joint swelling	348.74	9.64	868	521874	287778	78933868
Infusion related reaction	347.42	9.64	610	522132	229627	78992019
Glossodynia	344.84	9.64	123	522619	103214	79118432
Rheumatoid arthritis	319.37	9.64	547	522195	207923	79013723
Chronic kidney disease	318.75	9.64	1057	521685	65097	79156549
Duodenal ulcer perforation	313.59	9.64	34	522708	66177	79155469
Subacute cutaneous lupus erythematosus	308.19	9.64	225	522517	3336	79218310
Hepatic enzyme increased	276.17	9.64	483	522259	182127	79039519
Helicobacter infection	267.27	9.64	64	522678	69640	79152006
Maternal exposure during pregnancy	253.50	9.64	313	522429	136225	79085421
C-reactive protein abnormal	250.40	9.64	17	522725	48350	79173296
Drug abuse	249.02	9.64	427	522315	162264	79059382
Discomfort	222.82	9.64	298	522444	125319	79096327
Product use issue	219.01	9.64	677	522065	209145	79012501
Muscle injury	215.21	9.64	31	522711	48530	79173116
Pericarditis	209.67	9.64	224	522518	104012	79117634
Folliculitis	208.14	9.64	53	522689	55327	79166319
Sleep disorder due to general medical condition, insomnia type	207.19	9.64	22	522720	43534	79178112
Hypokalaemia	201.34	9.64	1624	521118	142416	79079230
Creatinine renal clearance decreased	194.81	9.64	403	522339	18599	79203047
Hypersensitivity	193.37	9.64	972	521770	261267	78960379
Completed suicide	191.04	9.64	894	521848	244873	78976773
Blood calcium decreased	189.07	9.64	547	522195	31272	79190374
Orthostatic hypotension	183.80	9.64	793	521949	55371	79166275
Nasopharyngitis	178.75	9.64	956	521786	252925	78968721
Irritable bowel syndrome	176.11	9.64	94	522648	62147	79159499
Rheumatic fever	171.62	9.64	3	522739	28522	79193124
Diarrhoea	170.41	9.64	7221	515521	873268	78348378
Tetany	168.05	9.64	141	522601	2587	79219059
Cognitive disorder	167.83	9.64	903	521839	69023	79152623
Therapeutic product effect incomplete	162.40	9.64	437	522305	141208	79080438
Weight increased	161.95	9.64	1108	521634	276278	78945368
Musculoskeletal stiffness	160.56	9.64	597	522145	174411	79047235
Impaired healing	153.35	9.64	210	522532	87445	79134201
Lip swelling	149.84	9.64	598	522144	40313	79181333
Alopecia	148.36	9.64	898	521844	230457	78991189
Swelling	145.42	9.64	829	521913	215882	79005764
Sedation complication	144.13	9.64	318	522424	15351	79206295
Psoriatic arthropathy	141.41	9.64	182	522560	77817	79143829
Hypoparathyroidism	129.60	9.64	84	522658	1014	79220632
Product use in unapproved indication	126.16	9.64	1042	521700	249317	78972329
Sinusitis	125.23	9.64	759	521983	194742	79026904
Stomatitis	122.92	9.64	519	522223	146238	79075408
Balance disorder	121.91	9.64	1084	521658	97773	79123873
Red blood cell sedimentation rate abnormal	119.29	9.64	4	522738	20959	79200687
Abdominal discomfort	118.10	9.64	1062	521680	249665	78971981
Constipation	110.11	9.64	2529	520213	280521	78941125
Infection	109.44	9.64	1034	521708	240678	78980968
Vomiting	107.73	9.64	5365	517377	660463	78561183
Intentional product use issue	106.86	9.64	573	522169	151539	79070107
Blood pressure systolic increased	103.18	9.64	175	522567	66811	79154835
Renal failure	103.07	9.64	1871	520871	199097	79022549
Inappropriate antidiuretic hormone secretion	102.34	9.64	392	522350	25921	79195725
Exposure during pregnancy	102.15	9.64	331	522411	100801	79120845
Swollen tongue	101.63	9.64	549	522193	42021	79179625
Condition aggravated	100.99	9.64	2507	520235	498617	78723029
Renal injury	100.56	9.64	291	522451	16636	79205010
Ill-defined disorder	99.73	9.64	174	522568	65701	79155945
Lethargy	98.99	9.64	889	521853	80403	79141243
Cardiospasm	98.75	9.64	115	522627	3186	79218460
Palmoplantar keratoderma	97.32	9.64	121	522621	3595	79218051
Arthralgia	94.34	9.64	2942	519800	568861	78652785
Blood cholesterol increased	93.90	9.64	261	522481	83459	79138187
Therapy non-responder	92.60	9.64	303	522439	92002	79129644
Abdominal pain	90.71	9.64	3262	519480	386307	78835339
Gastrointestinal haemorrhage	90.63	9.64	1416	521326	146303	79075343
Plasma cell myeloma	88.15	9.64	625	522117	52634	79169012
Liver function test abnormal	86.82	9.64	721	522021	63754	79157892
Rhabdomyolysis	86.72	9.64	1046	521696	102085	79119561
End stage renal disease	84.42	9.64	222	522520	11998	79209648
Hallucination	83.99	9.64	896	521846	84849	79136797
Metabolic alkalosis	83.80	9.64	124	522618	4365	79217281
Gastric pH decreased	83.59	9.64	59	522683	827	79220819
Blood pressure fluctuation	81.66	9.64	201	522541	66944	79154702
Metabolic acidosis	79.72	9.64	860	521882	81669	79139977
Drug resistance	79.12	9.64	96	522646	42117	79179529
Confusional state	78.79	9.64	2682	520060	315315	78906331
Pruritus genital	78.17	9.64	120	522622	4366	79217280
Rheumatoid nodule	77.57	9.64	11	522731	17427	79204219
Angioedema	77.04	9.64	800	521942	75235	79146411
General physical health deterioration	75.13	9.64	1310	521432	273928	78947718
Hyperkalaemia	74.95	9.64	1109	521633	113289	79108357
Bone erosion	73.28	9.64	14	522728	17833	79203813
Atrial tachycardia	72.78	9.64	151	522591	6982	79214664
Type 2 diabetes mellitus	72.64	9.64	167	522575	56955	79164691
Gastric polyps	72.11	9.64	105	522637	3642	79218004
Fibromyalgia	71.84	9.64	201	522541	64139	79157507
Pain	70.88	9.64	3832	518910	699970	78521676
Sleep terror	70.41	9.64	114	522628	4344	79217302
Therapeutic response decreased	70.18	9.64	215	522527	66638	79155008
Tension headache	68.20	9.64	148	522594	7063	79214583
Osteoarthritis	68.10	9.64	317	522425	86992	79134654
Blood pressure systolic abnormal	67.77	9.64	15	522727	17232	79204414
Tenosynovitis	66.47	9.64	11	522731	15543	79206103
Device expulsion	66.19	9.64	44	522698	25817	79195829
Myalgia	64.64	9.64	1634	521108	184007	79037639
Hip arthroplasty	64.21	9.64	84	522658	35672	79185974
International normalised ratio increased	63.43	9.64	841	521901	83880	79137766
Neutropenic sepsis	62.56	9.64	346	522396	26718	79194928
Hypertrichosis	62.45	9.64	58	522684	1224	79220422
Sedation	62.39	9.64	566	522176	51329	79170317
Blood pressure diastolic abnormal	62.11	9.64	24	522718	19178	79202468
Rectal haemorrhage	61.59	9.64	768	521974	75532	79146114
Facet joint syndrome	61.47	9.64	3	522739	11299	79210347
Heart rate decreased	61.14	9.64	245	522497	70071	79151575
Neutrophil count increased	60.88	9.64	365	522377	29031	79192615
Drug tolerance decreased	60.60	9.64	7	522735	12971	79208675
Blood pressure increased	59.91	9.64	999	521743	210361	79011285
Upper gastrointestinal haemorrhage	59.64	9.64	470	522272	40910	79180736
Immunisation	59.07	9.64	72	522670	2095	79219551
Renal tubular acidosis	57.88	9.64	93	522649	3521	79218125
Swelling face	57.14	9.64	716	522026	70496	79151150
Pancreatitis acute	57.10	9.64	536	522206	49068	79172578
Drug level increased	56.95	9.64	450	522292	39201	79182445
Haematemesis	56.83	9.64	558	522184	51706	79169940
Bursitis	56.72	9.64	92	522650	35752	79185894
Tinnitus	56.63	9.64	490	522252	43843	79177803
Enthesopathy	54.86	9.64	6	522736	11602	79210044
Pregnancy	54.76	9.64	57	522685	26794	79194852
Malignant neoplasm progression	54.38	9.64	599	522143	135391	79086255
Labelled drug-drug interaction medication error	53.90	9.64	338	522404	27312	79194334
Dehydration	53.53	9.64	2061	520681	246126	78975520
Gastritis	53.46	9.64	515	522227	47478	79174168
Red blood cell sedimentation rate increased	53.18	9.64	141	522601	45801	79175845
Blood magnesium decreased	53.13	9.64	232	522510	16280	79205366
Infective pulmonary exacerbation of cystic fibrosis	52.92	9.64	195	522547	12656	79208990
Abnormal loss of weight	52.68	9.64	147	522595	8229	79213417
Electrocardiogram QT prolonged	52.62	9.64	859	521883	89527	79132119
Anosmia	52.49	9.64	152	522590	8692	79212954
Deep vein thrombosis postoperative	52.26	9.64	5	522737	10747	79210899
Malaise	51.80	9.64	3803	518939	486066	78735580
Jaundice	50.62	9.64	554	522188	52795	79168851
Facial pain	50.52	9.64	187	522555	12163	79209483
Hypotension	50.29	9.64	3440	519302	436877	78784769
Grip strength decreased	49.80	9.64	42	522700	21827	79199819
Renal impairment	49.78	9.64	1371	521371	156412	79065234
Therapy partial responder	49.61	9.64	26	522716	17371	79204275
Toxic epidermal necrolysis	49.47	9.64	478	522264	44103	79177543
Abortion spontaneous	49.31	9.64	73	522669	29434	79192212
Breast cancer stage III	49.30	9.64	4	522738	9822	79211824
Adverse event	47.92	9.64	217	522525	59997	79161649
Carotid artery occlusion	47.89	9.64	134	522608	7513	79214133
Cogwheel rigidity	47.46	9.64	78	522664	3010	79218636
Chromaturia	47.28	9.64	310	522432	25436	79196210
Lip dry	47.08	9.64	21	522721	15397	79206249
Dizziness	46.71	9.64	4032	518710	522409	78699237
Respiratory arrest	46.64	9.64	206	522536	57344	79164302
Hypoglycaemia	45.93	9.64	928	521814	100666	79120980
Joint range of motion decreased	45.89	9.64	93	522649	33189	79188457
Hypophosphataemia	45.64	9.64	254	522488	19659	79201987
Product formulation issue	45.47	9.64	43	522699	929	79220717
Fall	45.34	9.64	3748	518994	483881	78737765
Live birth	45.20	9.64	34	522708	18710	79202936
Toxicity to various agents	45.00	9.64	2281	520461	419259	78802387
Muscle twitching	44.76	9.64	297	522445	24467	79197179
Musculoskeletal pain	44.52	9.64	442	522300	101912	79119734
Blister	44.36	9.64	535	522207	118941	79102705
Type I hypersensitivity	43.59	9.64	92	522650	4306	79217340
Prescribed overdose	43.30	9.64	117	522625	37766	79183880
Syncope	43	9.64	1508	521234	177941	79043705
Myelosuppression	42.71	9.64	129	522613	40167	79181479
Abdominal pain upper	42.36	9.64	1833	520909	221986	78999660
Muscle spasticity	42.22	9.64	47	522695	21428	79200218
Gastrointestinal disorder	41.73	9.64	557	522185	121648	79099998
Breast cancer stage II	41.60	9.64	3	522739	8117	79213529
Hypoparathyroidism secondary	41.37	9.64	23	522719	205	79221441
Body temperature decreased	40.85	9.64	94	522648	32051	79189595
Panniculitis	40.79	9.64	15	522727	12356	79209290
Immune reconstitution inflammatory syndrome	40.49	9.64	20	522722	13821	79207825
Aplastic anaemia	40.03	9.64	35	522707	17870	79203776
Multimorbidity	39.53	9.64	48	522694	1391	79220255
Circulatory collapse	39.42	9.64	399	522343	37269	79184377
Blood creatinine increased	39.41	9.64	1312	521430	153745	79067901
Loss of personal independence in daily activities	39.36	9.64	456	522286	102124	79119522
Hepatic encephalopathy	39.06	9.64	282	522460	23884	79197762
Inappropriate schedule of product administration	38.70	9.64	629	522113	132999	79088647
Blood pressure diastolic decreased	38.69	9.64	88	522654	30128	79191518
Dyspnoea	38.55	9.64	6285	516457	850740	78370906
Blood urea increased	38.47	9.64	489	522253	48301	79173345
Cross sensitivity reaction	38.37	9.64	79	522663	3633	79218013
Suicide attempt	38.24	9.64	353	522389	82579	79139067
Tremor	38.23	9.64	1419	521323	168664	79052982
Drug ineffective for unapproved indication	38.22	9.64	189	522553	51049	79170597
Blood sodium decreased	38.10	9.64	359	522383	32896	79188750
Knee arthroplasty	38.03	9.64	150	522592	43098	79178548
Derealisation	37.39	9.64	50	522692	1599	79220047
Haemoglobin decreased	37.24	9.64	1797	520945	220322	79001324
Atrial fibrillation	36.85	9.64	1618	521124	196268	79025378
Rash	36.68	9.64	3278	519464	575080	78646566
Disorientation	36.68	9.64	597	522145	62179	79159467
Autoimmune disorder	36.50	9.64	33	522709	16579	79205067
Arthritis	36.24	9.64	532	522210	114348	79107298
Sopor	36.20	9.64	104	522638	32906	79188740
Transient ischaemic attack	36.14	9.64	515	522227	52180	79169466
Depersonalisation/derealisation disorder	35.57	9.64	52	522690	1810	79219836
Electrolyte imbalance	35.20	9.64	333	522409	30548	79191098
Gastric mucosal hypertrophy	34.77	9.64	22	522720	254	79221392
Mania	34.22	9.64	221	522521	18039	79203607
Mouth swelling	34.01	9.64	102	522640	5949	79215697
Adjustment disorder with depressed mood	33.56	9.64	9	522733	9077	79212569
Oesophagitis	33.43	9.64	273	522469	24016	79197630
Immunosuppressant drug level increased	33.09	9.64	132	522610	8895	79212751
Disturbance in attention	33.06	9.64	492	522250	50309	79171337
Hallucinations, mixed	33.00	9.64	110	522632	6789	79214857
Feeling of despair	32.72	9.64	63	522679	2758	79218888
Device difficult to use	32.63	9.64	24	522718	13361	79208285
Obstructive airways disorder	32.43	9.64	102	522640	31357	79190289
Anaemia	32.36	9.64	3361	519381	441654	78779992
Pulmonary embolism	32.06	9.64	1404	521338	170250	79051396
Parkinsonism	31.87	9.64	202	522540	16382	79205264
Dry skin	31.70	9.64	624	522118	67371	79154275
Injection site pain	31.64	9.64	630	522112	129208	79092438
Urinary tract infection	31.52	9.64	2146	520596	272366	78949280
Disability	30.97	9.64	40	522702	17080	79204566
Burning mouth syndrome	30.84	9.64	27	522715	526	79221120
Blindness	30.84	9.64	303	522439	28080	79193566
Malignant mediastinal neoplasm	30.71	9.64	42	522700	1373	79220273
Faeces discoloured	30.70	9.64	309	522433	28818	79192828
Dislocation of vertebra	30.67	9.64	7	522735	7873	79213773
Pain of skin	30.61	9.64	182	522560	14431	79207215
Drooling	30.54	9.64	97	522645	5837	79215809
Hyperhidrosis	30.53	9.64	1249	521493	150243	79071403
Acidosis	30.45	9.64	228	522514	19534	79202112
Pulmonary malformation	30.43	9.64	19	522723	214	79221432
Device use error	30.40	9.64	5	522737	7096	79214550
Palatal oedema	30.34	9.64	42	522700	1389	79220257
Mucormycosis	30.14	9.64	9	522733	8460	79213186
Unintentional medical device removal	29.72	9.64	7	522735	7705	79213941
Palpitations	29.58	9.64	1061	521681	125549	79096097
Drug tolerance	29.49	9.64	10	522732	8665	79212981
Hepatitis cholestatic	29.33	9.64	173	522569	13679	79207967
Wrong technique in product usage process	29.28	9.64	326	522416	73549	79148097
Inflammation	29.28	9.64	435	522307	93318	79128328
Accidental exposure to product	29.25	9.64	106	522636	31216	79190430
Ventricular tachycardia	29.22	9.64	411	522331	41524	79180122
Occupational dermatitis	29.12	9.64	16	522726	139	79221507
Drug dependence	28.93	9.64	153	522589	40616	79181030
H1N1 influenza	28.90	9.64	56	522686	2463	79219183
Depressed level of consciousness	28.57	9.64	833	521909	95819	79125827
Coma	28.40	9.64	476	522266	100173	79121473
Vision blurred	28.18	9.64	901	521841	104997	79116649
Melaena	28.12	9.64	558	522184	60332	79161314
Breast cancer stage I	28.06	9.64	5	522737	6695	79214951
Liver injury	27.85	9.64	237	522505	56377	79165269
Muscle spasms	27.69	9.64	1406	521336	173324	79048322
Right hemisphere deficit syndrome	27.58	9.64	9	522733	15	79221631
Pathogen resistance	27.53	9.64	32	522710	14310	79207336
Sciatica	27.48	9.64	118	522624	33104	79188542
Caesarean section	27.43	9.64	25	522717	12510	79209136
Hypergastrinaemia	27.41	9.64	17	522725	189	79221457
Asthenia	27.34	9.64	3790	518952	507899	78713747
Peripheral swelling	27.20	9.64	1467	521275	268150	78953496
Sensitisation	26.91	9.64	64	522678	3247	79218399
Multiple-drug resistance	26.89	9.64	12	522730	8796	79212850
Parosmia	26.87	9.64	104	522638	6910	79214736
Poisoning	26.71	9.64	81	522661	25191	79196455
Catatonia	26.62	9.64	12	522730	8744	79212902
Obesity	26.52	9.64	129	522613	34996	79186650
Serotonin syndrome	26.22	9.64	428	522314	44599	79177047
Muscular weakness	26.22	9.64	1297	521445	159432	79062214
Soft tissue mass	26.11	9.64	37	522705	1251	79220395
Subarachnoid haemorrhage	26.01	9.64	260	522482	24205	79197441
Product substitution issue	25.93	9.64	224	522518	20032	79201614
Long QT syndrome	25.91	9.64	92	522650	5863	79215783
Injury	25.80	9.64	355	522387	77141	79144505
Renal cyst haemorrhage	25.70	9.64	27	522715	665	79220981
Bicytopenia	25.57	9.64	78	522664	4592	79217054
Device dislocation	25.52	9.64	86	522656	25884	79195762
Agitation	25.39	9.64	844	521898	98871	79122775
Atrioventricular block first degree	25.17	9.64	154	522588	12337	79209309
Herpes zoster	25.05	9.64	444	522298	92639	79129007
Choluria	25.04	9.64	21	522721	385	79221261
Post transplant lymphoproliferative disorder	24.92	9.64	23	522719	11441	79210205
Human herpesvirus 6 infection	24.82	9.64	3	522739	5367	79216279
Rash papular	24.81	9.64	236	522506	21680	79199966
Dysgeusia	24.76	9.64	519	522223	56658	79164988
Tongue oedema	24.44	9.64	102	522640	7015	79214631
Injection site bruising	24.27	9.64	163	522579	40839	79180807
Product packaging confusion	23.98	9.64	17	522725	240	79221406
White blood cell count increased	23.94	9.64	650	522092	73983	79147663
Infective exacerbation of chronic obstructive airways disease	23.93	9.64	55	522687	2729	79218917
Therapeutic response shortened	23.91	9.64	42	522700	15821	79205825
Hypochromasia	23.81	9.64	26	522716	670	79220976
Dissociation	23.76	9.64	69	522673	3952	79217694
Adjusted calcium decreased	23.62	9.64	16	522726	209	79221437
Interstitial lung disease	23.50	9.64	560	522182	112040	79109606
Hyperparathyroidism secondary	23.36	9.64	53	522689	2607	79219039
Blood pressure diastolic increased	23.31	9.64	37	522705	14505	79207141
Jejunal ulcer perforation	23.18	9.64	13	522729	118	79221528
Tachycardia	23.17	9.64	1405	521337	176363	79045283
Blood gastrin increased	23.08	9.64	10	522732	48	79221598
Gastrointestinal mucosal exfoliation	22.93	9.64	16	522726	220	79221426
Flatulence	22.66	9.64	400	522342	42324	79179322
Dilatation intrahepatic duct acquired	22.56	9.64	26	522716	712	79220934
Intraductal papillary mucinous neoplasm	22.55	9.64	27	522715	771	79220875
Bladder cancer	22.54	9.64	60	522682	19466	79202180
Progressive multifocal leukoencephalopathy	22.52	9.64	65	522677	20535	79201111
Prescribed underdose	22.51	9.64	108	522634	29406	79192240
Exostosis	22.49	9.64	48	522694	16810	79204836
C-reactive protein	22.48	9.64	3	522739	4976	79216670
Lung cyst	22.25	9.64	18	522724	313	79221333
Cutaneous lupus erythematosus	22.23	9.64	56	522686	2947	79218699
Nephrogenic anaemia	22.14	9.64	66	522676	3836	79217810
Feeling of body temperature change	22.08	9.64	81	522661	5245	79216401
Blood potassium decreased	22.07	9.64	428	522314	46084	79175562
Agitated depression	21.97	9.64	20	522722	411	79221235
Paraesthesia	21.95	9.64	1388	521354	174935	79046711
Oesophageal perforation	21.91	9.64	38	522704	1533	79220113
Clostridium difficile infection	21.70	9.64	397	522345	42288	79179358
Tetanus	21.69	9.64	10	522732	57	79221589
Injection site reaction	21.61	9.64	242	522500	54543	79167103
Eye pruritus	21.58	9.64	218	522524	20352	79201294
Superinfection	21.56	9.64	76	522666	4826	79216820
Calcium deficiency	21.53	9.64	28	522714	871	79220775
Pulmonary toxicity	21.53	9.64	32	522710	12882	79208764
Indifference	21.49	9.64	17	522725	286	79221360
Lower limb fracture	21.39	9.64	79	522663	23136	79198510
Drug reaction with eosinophilia and systemic symptoms	21.32	9.64	562	522180	63682	79157964
Blood chromogranin A increased	21.21	9.64	21	522721	481	79221165
Blood creatine phosphokinase increased	21.03	9.64	575	522167	65515	79156131
X-ray abnormal	21.02	9.64	6	522736	5807	79215839
Degenerative mitral valve disease	20.90	9.64	17	522725	298	79221348
Malignant spinal cord compression	20.85	9.64	13	522729	146	79221500
Pancreatitis	20.81	9.64	593	522149	67982	79153664
Hypoaesthesia oral	20.67	9.64	161	522581	13963	79207683
Hypergammaglobulinaemia	20.66	9.64	25	522717	722	79220924
Burning sensation	20.65	9.64	517	522225	58115	79163531
Torus fracture	20.58	9.64	11	522731	90	79221556
Road traffic accident	20.50	9.64	185	522557	43479	79178167
Drug use disorder	20.47	9.64	16	522726	8635	79213011
Stress	20.40	9.64	383	522359	79229	79142417
Multiple drug therapy	20.38	9.64	66	522676	4012	79217634
Abdominal tenderness	20.33	9.64	129	522613	10465	79211181
Incision site pain	20.15	9.64	52	522690	2778	79218868
Genital ulceration	19.98	9.64	30	522712	1070	79220576
Oesophageal atresia	19.98	9.64	11	522731	96	79221550
Wound infection	19.97	9.64	85	522657	23906	79197740
Presyncope	19.89	9.64	379	522363	40675	79180971
Polyuria	19.73	9.64	167	522575	14847	79206799
Restless legs syndrome	19.68	9.64	210	522532	19882	79201764
Haemophagocytic lymphohistiocytosis	19.67	9.64	75	522667	21762	79199884
Substance abuse	19.66	9.64	24	522718	10502	79211144
Ejection fraction abnormal	19.66	9.64	47	522695	2393	79219253
Breast cancer female	19.50	9.64	28	522714	11433	79210213
Pulmonary pain	19.37	9.64	69	522673	4404	79217242
Personality disorder	19.36	9.64	8	522734	6138	79215508
Leukocytosis	19.32	9.64	396	522346	43059	79178587
Epstein-Barr virus infection	19.27	9.64	41	522701	14375	79207271
Rash macular	19.24	9.64	281	522461	28618	79193028
Duodenitis	19.18	9.64	103	522639	7864	79213782
Metastases to lymph nodes	19.11	9.64	24	522718	10373	79211273
Adverse drug reaction	19.05	9.64	313	522429	66079	79155567
Premature delivery	19.01	9.64	84	522658	23383	79198263
Lung disorder	18.99	9.64	393	522349	80164	79141482
Sepsis	18.86	9.64	2030	520712	267398	78954248
Calciphylaxis	18.83	9.64	61	522681	3709	79217937
Poisoning deliberate	18.74	9.64	62	522680	18766	79202880
Occult blood positive	18.67	9.64	92	522650	6791	79214855
Ventilation perfusion mismatch	18.65	9.64	22	522720	618	79221028
Acute generalised exanthematous pustulosis	18.65	9.64	184	522558	17070	79204576
Oxygen saturation decreased	18.60	9.64	675	522067	128372	79093274
Injection site erythema	18.58	9.64	381	522361	77816	79143830
Skin exfoliation	18.57	9.64	483	522259	54617	79167029
Fear of eating	18.55	9.64	19	522723	454	79221192
Iron deficiency anaemia	18.45	9.64	253	522489	25419	79196227
Moraxella test positive	18.43	9.64	7	522735	22	79221624
Discoloured vomit	18.37	9.64	34	522708	1444	79220202
Coronary artery disease	18.35	9.64	310	522432	65164	79156482
Nephropathy	18.34	9.64	118	522624	9620	79212026
Oropharyngeal blistering	18.13	9.64	24	522718	760	79220886
Colorectal cancer	18.04	9.64	18	522724	8629	79213017
Intentional overdose	17.92	9.64	543	522199	105417	79116229
SARS-CoV-2 antibody test positive	17.88	9.64	18	522724	421	79221225
Polymyositis	17.85	9.64	52	522690	2984	79218662
Deformity	17.83	9.64	22	522720	9583	79212063
Faecal calprotectin increased	17.80	9.64	7	522735	5534	79216112
Myoclonic dystonia	17.77	9.64	9	522733	65	79221581
Endophthalmitis	17.76	9.64	10	522732	6418	79215228
Vitamin B12 deficiency	17.70	9.64	94	522648	7147	79214499
Blood immunoglobulin E increased	17.69	9.64	81	522661	5801	79215845
Drug clearance decreased	17.69	9.64	55	522687	3272	79218374
Seizure	17.58	9.64	1452	521290	187382	79034264
Right atrial enlargement	17.58	9.64	17	522725	378	79221268
Swelling of eyelid	17.56	9.64	60	522682	3751	79217895
Deep vein thrombosis	17.54	9.64	965	521777	119954	79101692
Cytomegalovirus viraemia	17.53	9.64	36	522706	12785	79208861
Nightmare	17.43	9.64	252	522490	25609	79196037
Genital pain	17.42	9.64	24	522718	790	79220856
Hepatitis acute	17.41	9.64	167	522575	15375	79206271
Haemodialysis	17.39	9.64	189	522553	17979	79203667
Gastrooesophageal reflux disease	17.37	9.64	843	521899	103403	79118243
Urine calcium decreased	17.35	9.64	7	522735	27	79221619
Cerebral haematoma	17.34	9.64	100	522642	7842	79213804
Blood potassium increased	17.32	9.64	279	522463	28996	79192650
Vena cava injury	17.29	9.64	16	522726	336	79221310
Hyperreflexia	17.29	9.64	104	522638	8281	79213365
Urinary retention	17.26	9.64	490	522252	56140	79165506
Abnormal weight gain	17.22	9.64	47	522695	2597	79219049
Hypophagia	17.17	9.64	404	522338	44963	79176683
Acne	17.16	9.64	106	522636	27084	79194562
Hand-eye coordination impaired	17.16	9.64	7	522735	28	79221618
Pneumonia	17.12	9.64	4717	518025	655529	78566117
Tongue blistering	17.09	9.64	34	522708	1525	79220121
Carotid arteriosclerosis	17.09	9.64	47	522695	2609	79219037
Blood alkaline phosphatase increased	17.02	9.64	542	522200	63122	79158524
Oral pain	16.96	9.64	298	522444	31500	79190146
Abdominal sepsis	16.92	9.64	40	522702	2022	79219624
Osteoporosis	16.91	9.64	251	522491	53861	79167785
Injection site haemorrhage	16.89	9.64	110	522632	27760	79193886
Drug dose omission by device	16.87	9.64	10	522732	6240	79215406
Acute psychosis	16.85	9.64	63	522679	4117	79217529
Nasal polyps	16.77	9.64	14	522728	7313	79214333
Pneumonitis	16.76	9.64	520	522222	60340	79161306
Gastric xanthoma	16.74	9.64	5	522737	5	79221641
Foot deformity	16.72	9.64	91	522651	23983	79197663
Vasculitis	16.68	9.64	244	522498	24858	79196788
Memory impairment	16.66	9.64	894	521848	110840	79110806
Therapeutic product ineffective	16.55	9.64	38	522704	1884	79219762
Hallucination, visual	16.50	9.64	304	522438	32425	79189221
Atrioventricular block complete	16.46	9.64	174	522568	16436	79205210
Liver disorder	16.28	9.64	356	522386	72061	79149585
Crystal nephropathy	16.27	9.64	32	522710	1423	79220223
Haematotoxicity	16.22	9.64	50	522692	15469	79206177
Colitis ischaemic	16.22	9.64	163	522579	15196	79206450
Intestinal ulcer	16.14	9.64	39	522703	1999	79219647
Polycystic ovaries	16.12	9.64	58	522684	3721	79217925
Thermohypoaesthesia	16.06	9.64	10	522732	112	79221534
Cerebral infarction	16.02	9.64	207	522535	45469	79176177
Graft versus host disease in gastrointestinal tract	16.02	9.64	11	522731	6345	79215301
Respiratory tract malformation	15.99	9.64	10	522732	113	79221533
Vascular anastomotic haemorrhage	15.98	9.64	14	522728	273	79221373
Amylase increased	15.98	9.64	127	522615	11082	79210564
Viral mutation identified	15.90	9.64	3	522739	3855	79217791
Sensory loss	15.77	9.64	142	522600	12849	79208797
Skin necrosis	15.73	9.64	63	522679	18024	79203622
Delusional disorder, persecutory type	15.70	9.64	18	522724	490	79221156
Normal newborn	15.60	9.64	14	522728	7058	79214588
Ventricular hyperkinesia	15.49	9.64	14	522728	285	79221361
Ejection fraction	15.45	9.64	41	522701	2228	79219418
Appendicolith	15.44	9.64	20	522722	8531	79213115
Cytomegalovirus infection	15.42	9.64	192	522550	42452	79179194
Dialysis	15.40	9.64	187	522555	18275	79203371
Endoscopy abnormal	15.33	9.64	8	522734	62	79221584
Muscle disorder	15.28	9.64	76	522666	5631	79216015
Joint destruction	15.27	9.64	10	522732	5915	79215731
Gallbladder adenocarcinoma	15.27	9.64	10	522732	123	79221523
Use of accessory respiratory muscles	15.17	9.64	18	522724	509	79221137
Pancreatic abscess	15.15	9.64	9	522733	92	79221554
Joint stiffness	15.08	9.64	183	522559	40647	79180999
Drug eruption	15.08	9.64	200	522542	43735	79177911
Visceral pain	15.07	9.64	9	522733	93	79221553
Duodenal stenosis	15.07	9.64	22	522720	765	79220881
Miosis	15.03	9.64	53	522689	15736	79205910
Antipsychotic drug level decreased	15.02	9.64	28	522714	1196	79220450
Fatigue	14.96	9.64	5675	517067	924052	78297594
Injection site swelling	14.95	9.64	218	522524	46914	79174732
Gastrointestinal erosion	14.94	9.64	26	522716	1052	79220594
Potentiating drug interaction	14.88	9.64	104	522638	8715	79212931
Urinary tract infection pseudomonal	14.88	9.64	35	522707	1763	79219883
Impaired quality of life	14.87	9.64	152	522590	14234	79207412
Oral herpes	14.85	9.64	112	522630	27342	79194304
Hypertensive nephropathy	14.77	9.64	25	522717	989	79220657
Perineal cyst	14.73	9.64	13	522729	256	79221390
Pregnancy with contraceptive device	14.72	9.64	3	522739	3651	79217995
Intestinal dilatation	14.69	9.64	45	522697	2655	79218991
Adverse reaction	14.65	9.64	24	522718	9290	79212356
Metastases to liver	14.62	9.64	117	522625	28197	79193449
Hypocalcaemic seizure	14.61	9.64	8	522734	69	79221577
Hyperchlorhydria	14.60	9.64	38	522704	2041	79219605
Overdose	14.58	9.64	1025	521717	183181	79038465
Diplopia	14.56	9.64	304	522438	33162	79188484
Systemic infection	14.54	9.64	26	522716	9726	79211920
Cytomegalovirus chorioretinitis	14.52	9.64	9	522733	5481	79216165
Ulcer	14.50	9.64	126	522616	29846	79191800
Catarrh	14.47	9.64	39	522703	2139	79219507
Second primary malignancy	14.46	9.64	47	522695	14303	79207343
Blood copper increased	14.33	9.64	6	522736	26	79221620
Incorrect route of product administration	14.29	9.64	153	522589	34776	79186870
Food allergy	14.29	9.64	31	522711	10793	79210853
Product complaint	14.25	9.64	142	522600	13207	79208439
Arteriosclerotic gangrene	14.23	9.64	8	522734	73	79221573
Ventricular flutter	14.22	9.64	9	522733	104	79221542
Sexual dysfunction	14.18	9.64	18	522724	7745	79213901
Hypernatraemia	14.14	9.64	151	522591	14300	79207346
Bleeding time prolonged	14.12	9.64	28	522714	1253	79220393
Diffuse large B-cell lymphoma recurrent	14.04	9.64	5	522737	4202	79217444
Paraesthesia oral	14.01	9.64	200	522542	20271	79201375
Finger deformity	14.00	9.64	17	522725	7457	79214189
Alcohol use disorder	13.98	9.64	6	522736	28	79221618
Derailment	13.96	9.64	8	522734	76	79221570
Graft versus host disease	13.93	9.64	51	522691	14975	79206671
Drug dispensed to wrong patient	13.90	9.64	20	522722	686	79220960
Gastrointestinal polyp haemorrhage	13.86	9.64	17	522725	498	79221148
Mesenteric artery thrombosis	13.85	9.64	19	522723	623	79221023
Posterior reversible encephalopathy syndrome	13.85	9.64	108	522634	26173	79195473
Chest pain	13.84	9.64	2081	520661	280223	78941423
Sickle cell anaemia with crisis	13.83	9.64	19	522723	7903	79213743
Alanine aminotransferase abnormal	13.80	9.64	23	522719	8844	79212802
Acute interstitial pneumonitis	13.80	9.64	27	522715	1196	79220450
Sepsis neonatal	13.77	9.64	7	522735	51	79221595
Joint injury	13.75	9.64	135	522607	31200	79190446
Somatosensory evoked potentials abnormal	13.71	9.64	11	522731	189	79221457
Stevens-Johnson syndrome	13.69	9.64	345	522397	38821	79182825
Nephroangiosclerosis	13.65	9.64	14	522728	335	79221311
Temperature regulation disorder	13.63	9.64	11	522731	5842	79215804
Urine output increased	13.61	9.64	39	522703	2217	79219429
Bromhidrosis	13.59	9.64	5	522737	14	79221632
Hepatic haematoma	13.57	9.64	22	522720	839	79220807
Ventricular fibrillation	13.56	9.64	289	522453	31637	79190009
Metastases to lung	13.54	9.64	67	522675	18096	79203550
Extensor plantar response	13.53	9.64	34	522708	1787	79219859
Muscle rigidity	13.50	9.64	194	522548	19688	79201958
COVID-19 treatment	13.44	9.64	16	522726	454	79221192
Seronegative arthritis	13.40	9.64	7	522735	4685	79216961
Latent tetany	13.39	9.64	4	522738	4	79221642
Intraductal papillary breast neoplasm	13.39	9.64	4	522738	4	79221642
Achlorhydria	13.34	9.64	5	522737	15	79221631
Truncus coeliacus thrombosis	13.34	9.64	5	522737	15	79221631
Laryngeal discomfort	13.31	9.64	18	522724	582	79221064
Coronary arterial stent insertion	13.29	9.64	12	522730	6032	79215614
Drug dose titration not performed	13.19	9.64	21	522721	789	79220857
Tracheo-oesophageal fistula	13.17	9.64	18	522724	588	79221058
Exposure to toxic agent	13.13	9.64	25	522717	9133	79212513
Ectopic gastric mucosa	13.10	9.64	5	522737	16	79221630
Skin discolouration	13.05	9.64	357	522385	40677	79180969
Avian influenza	13.05	9.64	8	522734	87	79221559
Aspergillus infection	12.99	9.64	73	522669	19088	79202558
Mitral valve thickening	12.98	9.64	15	522727	412	79221234
Venoocclusive liver disease	12.97	9.64	37	522705	11734	79209912
Muscle contractions involuntary	12.96	9.64	54	522688	3711	79217935
Hyperosmolar state	12.94	9.64	19	522723	664	79220982
Cholecystitis chronic	12.92	9.64	110	522632	9796	79211850
Odynophagia	12.84	9.64	122	522620	11205	79210441
Nocardiosis	12.82	9.64	11	522731	5668	79215978
Ageusia	12.82	9.64	166	522576	16466	79205180
Radiation inflammation	12.77	9.64	22	522720	883	79220763
Dermatitis atopic	12.76	9.64	111	522631	9945	79211701
Poor sucking reflex	12.76	9.64	9	522733	126	79221520
Postictal state	12.73	9.64	34	522708	1855	79219791
Product dispensing error	12.70	9.64	138	522604	13125	79208521
Blood phosphorus decreased	12.68	9.64	81	522661	6587	79215059
Hypertension	12.67	9.64	1940	520802	329052	78892594
Postictal paralysis	12.66	9.64	14	522728	366	79221280
Thinking abnormal	12.63	9.64	137	522605	13024	79208622
DNA antibody	12.63	9.64	6	522736	37	79221609
Hepatitis B	12.61	9.64	22	522720	8310	79213336
Gastrointestinal stoma complication	12.57	9.64	42	522700	2595	79219051
Renal cell carcinoma	12.56	9.64	80	522662	6498	79215148
Gastric ischaemia	12.45	9.64	5	522737	19	79221627
Hair injury	12.45	9.64	5	522737	19	79221627
Blood parathyroid hormone decreased	12.45	9.64	32	522710	10504	79211142
Vascular compression	12.40	9.64	17	522725	557	79221089
Rebound acid hypersecretion	12.38	9.64	8	522734	96	79221550
High-grade B-cell lymphoma	12.35	9.64	9	522733	133	79221513
Cystitis haemorrhagic	12.33	9.64	26	522716	9146	79212500
Granuloma annulare	12.33	9.64	18	522724	626	79221020
Night sweats	12.32	9.64	254	522488	51841	79169805
Salmonellosis	12.30	9.64	33	522709	1805	79219841
Myoglobin blood increased	12.30	9.64	47	522695	3104	79218542
Sight disability	12.29	9.64	9	522733	134	79221512
Intercepted product preparation error	12.28	9.64	4	522738	3556	79218090
Hiatus hernia	12.27	9.64	218	522524	23094	79198552
Aminoaciduria	12.25	9.64	14	522728	380	79221266
Lipidosis	12.25	9.64	6	522736	40	79221606
Injection site pruritus	12.24	9.64	199	522543	42084	79179562
Blood electrolytes abnormal	12.22	9.64	34	522708	1900	79219746
Herpes simplex	12.22	9.64	40	522702	12147	79209499
Erythrodermic psoriasis	12.21	9.64	32	522710	1726	79219920
Skin test positive	12.15	9.64	25	522717	1149	79220497
Epstein-Barr virus associated lymphoproliferative disorder	12.13	9.64	4	522738	3528	79218118
Enterococcal infection	12.12	9.64	57	522685	15603	79206043
Oesophageal adenocarcinoma	12.11	9.64	21	522721	847	79220799
Tracheal aspiration procedure	12.10	9.64	3	522739	0	79221646
Multiple epiphyseal dysplasia	12.10	9.64	3	522739	0	79221646
Malabsorption	12.08	9.64	65	522677	4967	79216679
Urine chloride decreased	12.04	9.64	8	522734	101	79221545
Jaundice cholestatic	12.03	9.64	120	522622	11164	79210482
Endocrine ophthalmopathy	12.02	9.64	19	522723	709	79220937
Amino acid level increased	12.02	9.64	19	522723	709	79220937
Injection site warmth	12.00	9.64	53	522689	14754	79206892
Genital rash	11.97	9.64	23	522719	1005	79220641
Hepatic rupture	11.97	9.64	8	522734	102	79221544
Respiratory tract congestion	11.97	9.64	79	522663	19875	79201771
Mood swings	11.96	9.64	190	522552	19690	79201956
Intestinal pseudo-obstruction	11.95	9.64	41	522701	2568	79219078
Ventricular enlargement	11.95	9.64	19	522723	713	79220933
Hypoosmolar state	11.94	9.64	13	522729	334	79221312
Mouth ulceration	11.92	9.64	333	522409	38061	79183585
Bronchial secretion retention	11.90	9.64	6	522736	4098	79217548
Yellow skin	11.86	9.64	50	522692	3455	79218191
Burns second degree	11.78	9.64	41	522701	2587	79219059
Cystic fibrosis lung	11.75	9.64	9	522733	144	79221502
Sarcoidosis	11.74	9.64	23	522719	8312	79213334
Lactation disorder	11.73	9.64	11	522731	235	79221411
Cyanosis	11.70	9.64	231	522511	24951	79196695
Product monitoring error	11.67	9.64	99	522643	8807	79212839
Eyelid retraction	11.66	9.64	6	522736	45	79221601
Peritonitis	11.66	9.64	253	522489	27783	79193863
Feeling abnormal	11.62	9.64	1203	521539	157996	79063650
Aortic dilatation	11.59	9.64	32	522710	1780	79219866
Product taste abnormal	11.57	9.64	37	522705	2234	79219412
Gastroenteritis	11.55	9.64	299	522443	33783	79187863
Product physical consistency issue	11.48	9.64	21	522721	884	79220762
Chronic obstructive pulmonary disease	11.48	9.64	677	522065	84742	79136904
Hypertonia	11.46	9.64	84	522658	7148	79214498
Brain scan abnormal	11.45	9.64	25	522717	1198	79220448
Alveolitis	11.43	9.64	56	522686	4124	79217522
Renal disorder	11.39	9.64	359	522383	41746	79179900
Faecaloma	11.39	9.64	121	522621	11443	79210203
Large intestine infection	11.34	9.64	46	522696	3123	79218523
Haemoptysis	11.34	9.64	462	522280	55537	79166109
Hepatitis B reactivation	11.33	9.64	14	522728	6094	79215552
Peritonitis bacterial	11.32	9.64	104	522638	9463	79212183
Abdominal wall haemorrhage	11.31	9.64	18	522724	676	79220970
Enzyme induction	11.28	9.64	8	522734	113	79221533
Nephrectomy	11.28	9.64	35	522707	2080	79219566
Metastases to bone	11.25	9.64	104	522638	24323	79197323
Pseudoporphyria	11.23	9.64	17	522725	611	79221035
Red blood cell analysis abnormal	11.22	9.64	5	522737	26	79221620
Lymphangitis	11.21	9.64	27	522715	1381	79220265
Graft versus host disease in skin	11.18	9.64	14	522728	6059	79215587
Rheumatoid lung	11.17	9.64	7	522735	4238	79217408
Pneumocystis jirovecii pneumonia	11.15	9.64	148	522594	32360	79189286
Glomerular filtration rate decreased	11.14	9.64	210	522532	22492	79199154
Cardiac steatosis	11.13	9.64	6	522736	50	79221596
Peripheral venous disease	11.12	9.64	60	522682	15849	79205797
Acinetobacter test positive	11.11	9.64	11	522731	252	79221394
Walking aid user	11.11	9.64	32	522710	10116	79211530
Amyloidosis	11.09	9.64	41	522701	2665	79218981
Anal incontinence	11.07	9.64	174	522568	17994	79203652
Lip ulceration	11.06	9.64	37	522705	2288	79219358
Dementia	11.06	9.64	225	522517	24434	79197212
Blood lactic acid increased	11.03	9.64	130	522612	12614	79209032
Helicobacter test positive	11.02	9.64	26	522716	1312	79220334
Akathisia	11.02	9.64	47	522695	13212	79208434
Genital blister	10.99	9.64	8	522734	118	79221528
Lung consolidation	10.96	9.64	98	522644	8849	79212797
Injection site extravasation	10.94	9.64	30	522712	9639	79212007
Laryngitis	10.93	9.64	61	522681	15978	79205668
Retinopathy hypertensive	10.93	9.64	15	522727	492	79221154
Intestinal ischaemia	10.89	9.64	134	522608	13136	79208510
Product residue present	10.86	9.64	49	522693	3487	79218159
Sinus congestion	10.84	9.64	81	522661	19815	79201831
Emotional disorder	10.84	9.64	143	522599	14244	79207402
Bladder irritation	10.80	9.64	11	522731	261	79221385
Amyloid arthropathy	10.80	9.64	16	522726	564	79221082
Laryngeal squamous cell carcinoma	10.77	9.64	8	522734	122	79221524
Incontinence	10.76	9.64	141	522601	14023	79207623
Pharyngeal swelling	10.75	9.64	87	522655	7632	79214014
Jealous delusion	10.72	9.64	12	522730	318	79221328
Asphyxia	10.72	9.64	40	522702	11680	79209966
Mean cell volume increased	10.71	9.64	74	522668	6179	79215467
Urticaria vesiculosa	10.67	9.64	4	522738	12	79221634
Bronchopulmonary aspergillosis	10.66	9.64	94	522648	22200	79199446
Foetal exposure timing unspecified	10.65	9.64	6	522736	55	79221591
Vulvar basal cell carcinoma	10.64	9.64	5	522737	30	79221616
Plethoric face	10.64	9.64	5	522737	30	79221616
Carcinoid tumour of the gastrointestinal tract	10.63	9.64	7	522735	87	79221559
Paraneoplastic rash	10.63	9.64	7	522735	87	79221559
Fibrinolysis	10.63	9.64	7	522735	87	79221559
Cystic fibrosis	10.62	9.64	52	522690	3828	79217818
Device issue	10.59	9.64	120	522622	26988	79194658
Cataract	10.58	9.64	318	522424	61802	79159844
Poliomyelitis	10.56	9.64	6	522736	56	79221590
Lung opacity	10.53	9.64	11	522731	5163	79216483
Secondary immunodeficiency	10.53	9.64	4	522738	3230	79218416
Hypovolaemic shock	10.53	9.64	125	522617	12151	79209495
Supraventricular tachycardia	10.53	9.64	197	522545	21073	79200573
Parotid gland haemorrhage	10.50	9.64	5	522737	31	79221615
Nephritis	10.50	9.64	55	522687	4159	79217487
Ischaemic stroke	10.47	9.64	288	522454	32843	79188803
Hypomania	10.47	9.64	21	522721	7523	79214123
Asthma-chronic obstructive pulmonary disease overlap syndrome	10.46	9.64	4	522738	3217	79218429
Maternal exposure before pregnancy	10.46	9.64	8	522734	4365	79217281
Eye infection fungal	10.44	9.64	15	522727	514	79221132
Suspected suicide	10.41	9.64	35	522707	10541	79211105
Urticaria	10.37	9.64	1059	521683	184142	79037504
Eosinophilic fasciitis	10.37	9.64	11	522731	274	79221372
Blood magnesium increased	10.36	9.64	5	522737	3501	79218145
Ear infection	10.32	9.64	161	522581	34271	79187375
Chronic spontaneous urticaria	10.32	9.64	24	522718	1200	79220446
Torsade de pointes	10.31	9.64	181	522561	19131	79202515
Pancreatic pseudocyst	10.29	9.64	26	522716	1371	79220275
Bradycardia	10.28	9.64	1027	521715	134530	79087116
Hypoaesthesia	10.26	9.64	1024	521718	178328	79043318
Hepatobiliary infection	10.25	9.64	5	522737	33	79221613
Henoch-Schonlein purpura	10.23	9.64	40	522702	2670	79218976
Coeliac disease	10.22	9.64	39	522703	11312	79210334
Blood sodium increased	10.21	9.64	60	522682	4738	79216908
Adenocarcinoma gastric	10.20	9.64	30	522712	1731	79219915
Chronic graft versus host disease	10.18	9.64	18	522724	6763	79214883
Chronic kidney disease-mineral and bone disorder	10.18	9.64	15	522727	526	79221120
Rales	10.16	9.64	186	522556	19815	79201831
Nail bed bleeding	10.10	9.64	17	522725	669	79220977
Reaction to excipient	10.10	9.64	28	522714	1561	79220085
Electrocardiogram T wave inversion	10.06	9.64	65	522677	5307	79216339
Multiple endocrine neoplasia Type 1	10.04	9.64	3	522739	3	79221643
Stertor	10.04	9.64	3	522739	3	79221643
Multiple allergies	10.03	9.64	35	522707	10425	79211221
Ceruloplasmin increased	10.00	9.64	4	522738	15	79221631
Ischaemic nephropathy	10.00	9.64	5	522737	35	79221611
Bone cyst	9.98	9.64	5	522737	3428	79218218
Retroperitoneal fibrosis	9.98	9.64	17	522725	676	79220970
Superior mesenteric artery syndrome	9.96	9.64	9	522733	183	79221463
Chemotherapeutic drug level increased	9.96	9.64	12	522730	345	79221301
Oedematous pancreatitis	9.96	9.64	23	522719	1145	79220501
Bone marrow failure	9.89	9.64	257	522485	50850	79170796
Impaired work ability	9.85	9.64	82	522660	19599	79202047
Colitis	9.85	9.64	581	522161	72726	79148920
Incoherent	9.81	9.64	85	522657	7607	79214039
Product dose omission issue	9.81	9.64	1804	520938	245733	78975913
Hypervolaemia	9.78	9.64	357	522385	42333	79179313
Acute graft versus host disease	9.76	9.64	34	522708	10133	79211513
Gastroenteritis eosinophilic	9.76	9.64	11	522731	294	79221352
Electrocardiogram ST segment depression	9.74	9.64	60	522682	4818	79216828
Vasculitic rash	9.73	9.64	34	522708	2150	79219496
Neoplasm progression	9.71	9.64	261	522481	51421	79170225
Neutrophilia	9.70	9.64	87	522655	7864	79213782
Spondylitis	9.70	9.64	10	522732	4721	79216925
Teratogenicity	9.69	9.64	10	522732	241	79221405
Dactylitis	9.69	9.64	3	522739	2754	79218892
Hypopnoea	9.68	9.64	64	522678	5265	79216381
Primary hypoparathyroidism	9.66	9.64	5	522737	38	79221608
Fear	9.66	9.64	200	522542	21786	79199860
N-terminal prohormone brain natriuretic peptide	9.65	9.64	6	522736	67	79221579
Photopsia	9.65	9.64	64	522678	5272	79216374
Lenticular opacities	9.65	9.64	15	522727	552	79221094

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B05CB04	BLOOD AND BLOOD FORMING ORGANS BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS IRRIGATING SOLUTIONS Salt solutions
ATC	B05XA02	BLOOD AND BLOOD FORMING ORGANS BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS I.V. SOLUTION ADDITIVES Electrolyte solutions
CHEBI has role	CHEBI:65265	antacids
CHEBI has role	CHEBI:77965	food anti-caking agent

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Reduction of risk of upper gastrointestinal bleeding	indication	37372002

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
0.21GM/100ML;2.8GM/100ML;9.07GM/100ML	NORMOCARB HF 25	DIALYSIS SUPS	N021910	July 26, 2006	RX	SOLUTION	INJECTION	7300674	March 4, 2023	USE AS REPLACEMENT SOLUTION, HEMOFILTRATION SOLUTION OR HEMODIAFILTRATION SOLUTION IN CONTINUOUS RENAL REPLACEMENT THERAPY

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4018192	VUID
N0000146526	NUI
D01203	KEGG_DRUG
4018192	VANDF
C0074722	UMLSCUI
CHEBI:32139	CHEBI
CHEMBL1353	ChEMBL_ID
D017693	MESH_DESCRIPTOR_UI
DB01390	DRUGBANK_ID
8MDF5V39QO	UNII
516892	PUBCHEM_CID
36676	RXNORM
1720	MMSL
5473	MMSL
d00440	MMSL
000743	NDDF
001116	NDDF
011039	NDDF
387319002	SNOMEDCT_US
57376006	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Good Sense Omeprazole and Sodium Bicarbonate	HUMAN OTC DRUG LABEL	2	0113-0058	CAPSULE, GELATIN COATED	1100 mg	ORAL	ANDA	15 sections
Good Sense Omeprazole and Sodium Bicarbonate	HUMAN OTC DRUG LABEL	2	0113-0058	CAPSULE, GELATIN COATED	1100 mg	ORAL	ANDA	15 sections
Alka-Seltzer Heartburn	HUMAN OTC DRUG LABEL	2	0280-0047	TABLET, EFFERVESCENT	1940 mg	ORAL	OTC monograph final	17 sections
Alka-Seltzer Heartburn	HUMAN OTC DRUG LABEL	2	0280-0047	TABLET, EFFERVESCENT	1940 mg	ORAL	OTC monograph final	17 sections
Alka-Seltzer Heartburn Relief Extra Strength	HUMAN OTC DRUG LABEL	2	0280-0079	TABLET, EFFERVESCENT	1976 mg	ORAL	OTC monograph final	16 sections
Alka-Seltzer Heartburn Relief Extra Strength	HUMAN OTC DRUG LABEL	2	0280-0079	TABLET, EFFERVESCENT	1976 mg	ORAL	OTC monograph final	16 sections
Alka-Seltzer Heartburn Relief Lemon Lime	HUMAN OTC DRUG LABEL	2	0280-0083	TABLET, EFFERVESCENT	1976 mg	ORAL	OTC monograph final	16 sections
Alka-Seltzer Heartburn Relief Lemon Lime	HUMAN OTC DRUG LABEL	2	0280-0083	TABLET, EFFERVESCENT	1650 mg	ORAL	OTC monograph final	16 sections
Alka-Seltzer Extra Strength	HUMAN OTC DRUG LABEL	3	0280-0211	GRANULE, EFFERVESCENT	1985 mg	ORAL	OTC monograph not final	17 sections
Alka-Seltzer Extra Strength	HUMAN OTC DRUG LABEL	3	0280-0211	GRANULE, EFFERVESCENT	1985 mg	ORAL	OTC monograph not final	17 sections
Alka-Seltzer Original	HUMAN OTC DRUG LABEL	3	0280-4000	TABLET, EFFERVESCENT	1916 mg	ORAL	OTC monograph not final	17 sections
Alka-Seltzer Lemon Lime	HUMAN OTC DRUG LABEL	3	0280-4020	TABLET, EFFERVESCENT	1700 mg	ORAL	OTC monograph not final	16 sections
Alka-Seltzer Gold	HUMAN OTC DRUG LABEL	3	0280-4100	TABLET, EFFERVESCENT	1050 mg	ORAL	OTC monograph final	16 sections
Alka-Seltzer Gold	HUMAN OTC DRUG LABEL	3	0280-4100	TABLET, EFFERVESCENT	1050 mg	ORAL	OTC monograph final	16 sections
CEO-TWO	HUMAN OTC DRUG LABEL	2	0283-0808	SUPPOSITORY	618 mg	RECTAL	OTC monograph not final	15 sections
CEO-TWO	HUMAN OTC DRUG LABEL	2	0283-0808	SUPPOSITORY	618 mg	RECTAL	OTC monograph not final	15 sections
Walgreens Effervescent Pain Relief	HUMAN OTC DRUG LABEL	3	0363-0421	TABLET, EFFERVESCENT	1916 mg	ORAL	OTC monograph final	17 sections
Walgreens Effervescent Pain Relief	HUMAN OTC DRUG LABEL	3	0363-0421	TABLET, EFFERVESCENT	1916 mg	ORAL	OTC monograph final	17 sections
Walgreens Antacid Pain Relief Extra Strength	HUMAN OTC DRUG LABEL	3	0363-0541	TABLET, EFFERVESCENT	1985 mg	ORAL	OTC monograph final	17 sections
Walgreens Antacid Pain Relief Extra Strength	HUMAN OTC DRUG LABEL	3	0363-0541	TABLET, EFFERVESCENT	1985 mg	ORAL	OTC monograph final	17 sections
Omeprazole and sodium bicarbonate	HUMAN OTC DRUG LABEL	2	0363-0732	CAPSULE, GELATIN COATED	1100 mg	ORAL	ANDA	15 sections
Omeprazole and sodium bicarbonate	HUMAN OTC DRUG LABEL	2	0363-0732	CAPSULE, GELATIN COATED	1100 mg	ORAL	ANDA	15 sections
Omeprazole and sodium bicarbonate	HUMAN OTC DRUG LABEL	2	0363-0732	CAPSULE, GELATIN COATED	1100 mg	ORAL	ANDA	15 sections
Omeprazole and sodium bicarbonate	HUMAN OTC DRUG LABEL	2	0363-0732	CAPSULE, GELATIN COATED	1100 mg	ORAL	ANDA	15 sections
Well at Walgreens	HUMAN OTC DRUG LABEL	2	0363-0801	POWDER, FOR SOLUTION	700 mg	NASAL	unapproved drug other	11 sections
Well at Walgreens	HUMAN OTC DRUG LABEL	2	0363-0801	POWDER, FOR SOLUTION	700 mg	NASAL	unapproved drug other	11 sections
Well at Walgreens	HUMAN OTC DRUG LABEL	2	0363-0801	POWDER, FOR SOLUTION	700 mg	NASAL	unapproved drug other	11 sections
Well at Walgreens	HUMAN OTC DRUG LABEL	2	0363-0801	POWDER, FOR SOLUTION	700 mg	NASAL	unapproved drug other	11 sections
Well at Walgreens	HUMAN OTC DRUG LABEL	2	0363-0802	POWDER, FOR SOLUTION	700 mg	NASAL	unapproved drug other	11 sections
Well at Walgreens	HUMAN OTC DRUG LABEL	2	0363-0802	POWDER, FOR SOLUTION	700 mg	NASAL	unapproved drug other	11 sections