All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

sodium acetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4203	127-09-3

Description:

Molecule	Description
Synonyms: sodium acetate anhydrous sodium acetate acetic acid, sodium salt sodium acetate anhydrous	The trihydrate sodium salt of acetic acid, which is used as a source of sodium ions in solutions for dialysis and as a systemic and urinary alkalizer, diuretic, and expectorant. Molecular weight: 82.03 Formula: C2H3NaO2 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
May 4, 1983	FDA	HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxic anterior segment syndrome	518.37	66.46	69	463	1702	63486788
Endophthalmitis	227.57	66.46	37	495	3555	63484935
Post procedural complication	84.33	66.46	21	511	17053	63471437
Anterior chamber inflammation	72.12	66.46	10	522	317	63488173
Foetal growth restriction	67.30	66.46	15	517	7538	63480952

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxic anterior segment syndrome	449.81	43.79	61	391	1108	34955371
Endophthalmitis	139.94	43.79	26	426	3482	34952997
Post procedural complication	78.82	43.79	20	432	11368	34945111
Cataract operation complication	74.58	43.79	10	442	156	34956323
Keratitis	52.92	43.79	10	442	1441	34955038

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxic anterior segment syndrome	832.93	38.05	114	756	2650	79740868
Endophthalmitis	333.68	38.05	58	812	6370	79737148
Post procedural complication	137.55	38.05	35	835	23794	79719724
Cataract operation complication	128.55	38.05	17	853	284	79743234
Anterior chamber disorder	51.02	38.05	7	863	155	79743363
Keratitis	49.09	38.05	11	859	4311	79739207
Corneal oedema	42.84	38.05	9	861	2611	79740907
Intraocular pressure increased	40.83	38.05	11	859	9194	79734324
Corneal disorder	38.21	38.05	8	862	2283	79741235

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B05XA08	BLOOD AND BLOOD FORMING ORGANS BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS I.V. SOLUTION ADDITIVES Electrolyte solutions

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Anuria	contraindication	2472002	DOID:2983
Classical phenylketonuria	contraindication	7573000
Poisoning by digitalis glycoside	contraindication	12876009
Hyperkalemia	contraindication	14140009
Complete atrioventricular block	contraindication	27885002
Sarcoidosis	contraindication	31541009	DOID:11335
End stage renal disease	contraindication	46177005	DOID:784
Humoral hypercalcemia of malignancy	contraindication	47709007
Heart disease	contraindication	56265001	DOID:114
Congenital myotonia, autosomal dominant form	contraindication	57938005
Acute nephropathy	contraindication	58574008
Hypercalcemia	contraindication	66931009	DOID:12678
Ventricular fibrillation	contraindication	71908006
Hypercalciuria	contraindication	71938000
Hyperchloremia	contraindication	74450001
Third degree burn injury	contraindication	80247002
Oliguria	contraindication	83128009
Kidney disease	contraindication	90708001	DOID:557
Kidney stone	contraindication	95570007
Hyporeninemic hypoaldosteronism	contraindication	236464008
Familial hyperkalemic periodic paralysis	contraindication	304737009	DOID:14451
Azotemia	contraindication	445009001
Severe dehydration	contraindication	450316000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Carbonic anhydrase 1	Enzyme	P00915	CAH1_HUMAN		Ki	4.97		CHEMBL
Carbonic anhydrase	Enzyme		CAN_CANAL		Ki	4.44		CHEMBL

External reference:

ID	Source
4017442	VUID
N0000145830	NUI
4017442	VANDF
4018697	VANDF
C0142785	UMLSCUI
CHEBI:32954	CHEBI
CHEMBL1354	ChEMBL_ID
D019346	MESH_DESCRIPTOR_UI
DB09395	DRUGBANK_ID
4550K0SC9B	UNII
517045	PUBCHEM_CID
267453	RXNORM
1707	MMSL
5468	MMSL
72037	MMSL
NOCODE	MMSL
d00471	MMSL
000744	NDDF
000756	NDDF
6131-90-4	SECONDARY_CAS_RN

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
BSS	HUMAN PRESCRIPTION DRUG LABEL	6	0065-0795	SOLUTION	3.90 mg	OPHTHALMIC	NDA	9 sections
BSS	HUMAN PRESCRIPTION DRUG LABEL	6	0065-0795	SOLUTION	3.90 mg	OPHTHALMIC	NDA	9 sections
BSS	HUMAN PRESCRIPTION DRUG LABEL	6	0065-0795	SOLUTION	3.90 mg	OPHTHALMIC	NDA	9 sections
BSS	HUMAN PRESCRIPTION DRUG LABEL	6	0065-0795	SOLUTION	3.90 mg	OPHTHALMIC	NDA	9 sections
BSS	HUMAN PRESCRIPTION DRUG LABEL	6	0065-1795	SOLUTION	3.90 mg	OPHTHALMIC	NDA	9 sections
BSS	HUMAN PRESCRIPTION DRUG LABEL	6	0065-1795	SOLUTION	3.90 mg	OPHTHALMIC	NDA	9 sections
ProcalAmine	HUMAN PRESCRIPTION DRUG LABEL	22	0264-1915	INJECTION	0.20 g	INTRAVENOUS	NDA	24 sections
ProcalAmine	HUMAN PRESCRIPTION DRUG LABEL	22	0264-1915	INJECTION	0.20 g	INTRAVENOUS	NDA	24 sections
HyperlyteCR	HUMAN PRESCRIPTION DRUG LABEL	5	0264-1943	INJECTION, SOLUTION, CONCENTRATE	0.68 g	INTRAVENOUS	UNAPPROVED DRUG OTHER	18 sections
HyperlyteCR	HUMAN PRESCRIPTION DRUG LABEL	5	0264-1943	INJECTION, SOLUTION, CONCENTRATE	0.68 g	INTRAVENOUS	UNAPPROVED DRUG OTHER	18 sections
Balanced Salt	HUMAN PRESCRIPTION DRUG LABEL	6	0264-1945	SOLUTION	3.90 mg	IRRIGATION	ANDA	11 sections
Physiolyte	HUMAN PRESCRIPTION DRUG LABEL	5	0264-2205	IRRIGANT	0.37 g	IRRIGATION	NDA	20 sections
Physiolyte	HUMAN PRESCRIPTION DRUG LABEL	5	0264-2205	IRRIGANT	0.37 g	IRRIGATION	NDA	20 sections
Physiolyte	HUMAN PRESCRIPTION DRUG LABEL	5	0264-2205	IRRIGANT	0.37 g	IRRIGATION	NDA	20 sections
Physiolyte	HUMAN PRESCRIPTION DRUG LABEL	5	0264-2205	IRRIGANT	0.37 g	IRRIGATION	NDA	20 sections
Balanced Salt	HUMAN PRESCRIPTION DRUG LABEL	6	0264-2514	SOLUTION	3.90 mg	IRRIGATION	ANDA	11 sections
Isolyte S	HUMAN PRESCRIPTION DRUG LABEL	5	0264-7703	INJECTION, SOLUTION	0.37 g	INTRAVENOUS	NDA	19 sections
Isolyte S	HUMAN PRESCRIPTION DRUG LABEL	5	0264-7703	INJECTION, SOLUTION	0.37 g	INTRAVENOUS	NDA	19 sections
Isolyte S pH 7.4	HUMAN PRESCRIPTION DRUG LABEL	7	0264-7707	INJECTION, SOLUTION	0.37 g	INTRAVENOUS	NDA	24 sections
Isolyte S pH 7.4	HUMAN PRESCRIPTION DRUG LABEL	7	0264-7707	INJECTION, SOLUTION	0.37 g	INTRAVENOUS	NDA	24 sections
Isolyte S pH 7.4	HUMAN PRESCRIPTION DRUG LABEL	7	0264-7707	INJECTION, SOLUTION	0.37 g	INTRAVENOUS	NDA	24 sections
Isolyte S pH 7.4	HUMAN PRESCRIPTION DRUG LABEL	7	0264-7707	INJECTION, SOLUTION	0.37 g	INTRAVENOUS	NDA	24 sections
Isolyte P in Dextrose	HUMAN PRESCRIPTION DRUG LABEL	5	0264-7730	INJECTION, SOLUTION	0.32 g	INTRAVENOUS	NDA	23 sections
Isolyte P in Dextrose	HUMAN PRESCRIPTION DRUG LABEL	5	0264-7730	INJECTION, SOLUTION	0.32 g	INTRAVENOUS	NDA	23 sections
Isolyte P in Dextrose	HUMAN PRESCRIPTION DRUG LABEL	5	0264-7730	INJECTION, SOLUTION	0.32 g	INTRAVENOUS	NDA	23 sections
Isolyte P in Dextrose	HUMAN PRESCRIPTION DRUG LABEL	5	0264-7730	INJECTION, SOLUTION	0.32 g	INTRAVENOUS	NDA	23 sections
Plasma-Lyte 148	HUMAN PRESCRIPTION DRUG LABEL	5	0338-0179	INJECTION, SOLUTION	368 mg	INTRAVENOUS	NDA	20 sections
Plasma-Lyte 148	HUMAN PRESCRIPTION DRUG LABEL	5	0338-0179	INJECTION, SOLUTION	368 mg	INTRAVENOUS	NDA	20 sections
Plasma-Lyte 148	HUMAN PRESCRIPTION DRUG LABEL	5	0338-0179	INJECTION, SOLUTION	368 mg	INTRAVENOUS	NDA	20 sections
Plasma-Lyte 148	HUMAN PRESCRIPTION DRUG LABEL	5	0338-0179	INJECTION, SOLUTION	368 mg	INTRAVENOUS	NDA	20 sections