sodium lactate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4202	72-17-3

Description:

Molecule	Description
Synonyms: sodium lactate lacolin lactic acid sodium salt monosodium lactate	The sodium salt of racemic or inactive lactic acid. It is a hygroscopic agent used intravenously as a systemic and urinary alkalizer. Molecular weight: 112.06 Formula: C3H5NaO3 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

sodium lactate
lacolin
lactic acid sodium salt
monosodium lactate

The sodium salt of racemic or inactive lactic acid. It is a hygroscopic agent used intravenously as a systemic and urinary alkalizer.

Molecular weight: 112.06
Formula: C3H5NaO3
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
March 22, 1971	FDA	BAXTER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Death	834.56	32.33	423	3652	373958	63110989
Peritonitis bacterial	613.89	32.33	123	3952	4756	63480191
Peritonitis	455.26	32.33	122	3953	17032	63467915
Peritoneal dialysis complication	386.00	32.33	67	4008	1153	63483794
Fungal peritonitis	250.19	32.33	41	4034	488	63484459
Sepsis	189.08	32.33	119	3956	153004	63331943
Device interaction	184.19	32.33	28	4047	196	63484751
Ultrafiltration failure	104.19	32.33	17	4058	196	63484751
Encapsulating peritoneal sclerosis	102.41	32.33	18	4057	332	63484615
Peritoneal cloudy effluent	74.05	32.33	12	4063	132	63484815
Cardiac arrest	73.65	32.33	55	4020	92490	63392457
Cardiovascular disorder	66.75	32.33	26	4049	11786	63473161
Myocardial infarction	65.63	32.33	53	4022	99840	63385107
Hypervolaemia	64.50	32.33	33	4042	28380	63456567
Cardiac disorder	61.19	32.33	39	4036	50777	63434170
Cardiac failure	53.72	32.33	45	4030	89097	63395850
Cerebrovascular accident	50.08	32.33	47	4028	107977	63376970
Drug ineffective	49.56	32.33	5	4070	1044760	62440187
Gangrene	47.47	32.33	17	4058	6106	63478841
Bloody peritoneal effluent	44.99	32.33	7	4068	58	63484889
Marasmus	41.33	32.33	9	4066	516	63484431
Hypoglycaemia	39.67	32.33	32	4043	60033	63424914

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Peritonitis bacterial	825.52	30.79	190	5118	5920	34945703
Death	818.64	30.79	580	4728	397469	34554154
Peritonitis	515.43	30.79	161	5147	16204	34935419
Peritoneal dialysis complication	490.65	30.79	99	5209	1610	34950013
Fungal peritonitis	338.96	30.79	64	5244	719	34950904
Device interaction	144.99	30.79	30	5278	552	34951071
Myocardial infarction	122.59	30.79	119	5189	120966	34830657
Cardiac disorder	122.28	30.79	78	5230	43048	34908575
Encapsulating peritoneal sclerosis	115.98	30.79	25	5283	564	34951059
Cardiac failure	114.21	30.79	101	5207	91147	34860476
Ultrafiltration failure	113.96	30.79	20	5288	143	34951480
Gangrene	106.85	30.79	36	5272	4550	34947073
Cardiac arrest	90.66	30.79	91	5217	96068	34855555
Peritoneal cloudy effluent	86.64	30.79	16	5292	157	34951466
Noninfectious peritonitis	84.20	30.79	15	5293	118	34951505
Sepsis	83.69	30.79	114	5194	166447	34785176
Hypervolaemia	80.13	30.79	45	5263	19664	34931959
Cardiovascular disorder	63.94	30.79	31	5277	10025	34941598
Catheter site infection	58.96	30.79	20	5288	2577	34949046
Bloody peritoneal effluent	47.39	30.79	9	5299	104	34951519
Off label use	46.31	30.79	5	5303	419519	34532104
Peritoneal effluent abnormal	39.76	30.79	7	5301	51	34951572
Drug ineffective	36.62	30.79	12	5296	456739	34494884
Hernia	36.55	30.79	21	5287	9562	34942061
Cerebrovascular accident	35.01	30.79	53	5255	84758	34866865
Procedural pain	34.15	30.79	16	5292	4790	34946833
Blood glucose false positive	33.58	30.79	6	5302	48	34951575
Localised infection	31.41	30.79	24	5284	17563	34934060
Hypoglycaemia	31.31	30.79	40	5268	54600	34897023

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Peritonitis bacterial	1153.54	26.65	240	5916	9327	79728905
Peritonitis	638.36	26.65	184	5972	27852	79710380
Peritoneal dialysis complication	532.04	26.65	100	6056	2254	79735978
Death	526.08	26.65	394	5762	566120	79172112
Fungal peritonitis	360.42	26.65	64	6092	1036	79737196
Device interaction	261.41	26.65	46	6110	704	79737528
Encapsulating peritoneal sclerosis	178.63	26.65	34	6122	817	79737415
Sepsis	130.02	26.65	130	6026	269298	79468934
Cardiac arrest	126.04	26.65	105	6051	171991	79566241
Ultrafiltration failure	111.11	26.65	19	6137	243	79737989
Gangrene	107.06	26.65	36	6120	8928	79729304
Peritoneal cloudy effluent	106.22	26.65	19	6137	320	79737912
Myocardial infarction	83.45	26.65	86	6070	184043	79554189
Noninfectious peritonitis	77.86	26.65	14	6142	243	79737989
Cardiac disorder	71.92	26.65	51	6105	65706	79672526
Hypervolaemia	65.77	26.65	41	6115	42649	79695583
Blood glucose false positive	60.45	26.65	9	6147	43	79738189
Cardiac failure	58.96	26.65	66	6090	154776	79583456
Hypoglycaemia	56.28	26.65	53	6103	101541	79636691
Bloody peritoneal effluent	55.81	26.65	10	6146	170	79738062
Complication associated with device	55.28	26.65	27	6129	17469	79720763
Catheter site infection	53.37	26.65	20	6136	6775	79731457
Off label use	49.63	26.65	6	6150	907209	78831023
Drug ineffective	48.59	26.65	12	6144	1080901	78657331
Peritoneal effluent abnormal	39.01	26.65	6	6150	37	79738195
Pneumonia	36.76	26.65	123	6033	660123	79078109
Peritoneal disorder	36.66	26.65	9	6147	726	79737506
Diabetic complication	36.29	26.65	10	6146	1269	79736963
Abdominal distension	35.60	26.65	45	6111	119605	79618627
Hypotension	33.87	26.65	92	6064	440225	79298007
Haemodialysis	31.95	26.65	19	6137	18149	79720083
Procedural complication	30.36	26.65	14	6142	7969	79730263
Headache	29.80	26.65	7	6149	653765	79084467
Blood loss anaemia	29.33	26.65	17	6139	15481	79722751
Cerebrovascular accident	29.30	26.65	47	6109	155245	79582987
Arthralgia	28.38	26.65	5	6151	571798	79166434

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
CHEBI has role	CHEBI:64049	pH control agents
CHEBI has role	CHEBI:65255	food preservatives

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypokalemia	indication	43339004
Hypokalemia Prevention	indication
Brain damage	contraindication	2470005
Anuria	contraindication	2472002	DOID:2983
Tachyarrhythmia	contraindication	6285003
Urinary tract obstruction	contraindication	7163005	DOID:5200
Peptic ulcer	contraindication	13200003	DOID:750
Chronic obstructive lung disease	contraindication	13645005	DOID:3083
Hyperkalemia	contraindication	14140009
Severe chronic ulcerative colitis	contraindication	14311001
Myocardial infarction	contraindication	22298006	DOID:5844
Ventricular tachycardia	contraindication	25569003
Complete atrioventricular block	contraindication	27885002
Toxic megacolon	contraindication	28536002	DOID:1770
Atony of colon	contraindication	29479008
Hyperthyroidism	contraindication	34486009	DOID:7998
Acute hepatitis	contraindication	37871000
Hypertensive disorder	contraindication	38341003	DOID:10763
Complete trisomy 21 syndrome	contraindication	41040004	DOID:14250
Achalasia of esophagus	contraindication	45564002	DOID:9164
Chronic heart failure	contraindication	48447003
Bradycardia	contraindication	48867003
Acidosis	contraindication	51387008
Paralytic ileus	contraindication	55525008	DOID:8442
Peptic reflux disease	contraindication	57643001
Congenital myotonia, autosomal dominant form	contraindication	57938005
Acute nephropathy	contraindication	58574008
Ulcerative colitis	contraindication	64766004	DOID:8577
Arterial thrombosis	contraindication	65198009
Drug AND/OR toxin-induced diarrhea	contraindication	65979008
Arteriosclerotic vascular disease	contraindication	72092001
Hyperchloremia	contraindication	74450001
Spastic paralysis	contraindication	78403003
Disturbance of salivary secretion	contraindication	78948009
Third degree burn injury	contraindication	80247002
Chronic idiopathic constipation	contraindication	82934008
Oliguria	contraindication	83128009
Hiatal hernia	contraindication	84089009	DOID:12642
Kidney disease	contraindication	90708001	DOID:557
Myasthenia gravis	contraindication	91637004	DOID:437
Gastrointestinal obstruction	contraindication	126765001
Autonomic dysreflexia	contraindication	129618003
Bleeding	contraindication	131148009
Partial atrioventricular block	contraindication	195039008
Acute pancreatitis	contraindication	197456007	DOID:2913
Myocardial dysfunction	contraindication	233928007
Disease of liver	contraindication	235856003	DOID:409
Hyporeninemic hypoaldosteronism	contraindication	236464008
Bladder outflow obstruction	contraindication	236645006
Pyloric obstruction	contraindication	244815007
Benign prostatic hyperplasia	contraindication	266569009
Retention of urine	contraindication	267064002
Drowsy	contraindication	271782001
Familial hyperkalemic periodic paralysis	contraindication	304737009	DOID:14451
Hypoxia	contraindication	389086002
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Gastric ulcer	contraindication	397825006	DOID:10808
Chronic lung disease	contraindication	413839001
Disorder of coronary artery	contraindication	414024009
Hypertensive urgency	contraindication	443482000
Azotemia	contraindication	445009001
Severe dehydration	contraindication	450316000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4018691	VUID
N0000147000	NUI
D02183	KEGG_DRUG
4018691	VANDF
C0142874	UMLSCUI
CHEBI:75228	CHEBI
CHEMBL1357	ChEMBL_ID
D019354	MESH_DESCRIPTOR_UI
4157	INN_ID
TU7HW0W0QT	UNII
23666456	PUBCHEM_CID
56489	RXNORM
1084	MMSL
5487	MMSL
d00469	MMSL
000750	NDDF
000760	NDDF
015438	NDDF
387306001	SNOMEDCT_US
55015008	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Lactated Ringers	HUMAN PRESCRIPTION DRUG LABEL	4	0264-2203	IRRIGANT	0.31 g	IRRIGATION	NDA	18 sections
Lactated Ringers	HUMAN PRESCRIPTION DRUG LABEL	4	0264-2203	IRRIGANT	0.31 g	IRRIGATION	NDA	18 sections
Lactated Ringers	HUMAN PRESCRIPTION DRUG LABEL	4	0264-2203	IRRIGANT	0.31 g	IRRIGATION	NDA	18 sections
Lactated Ringers	HUMAN PRESCRIPTION DRUG LABEL	4	0264-2203	IRRIGANT	0.31 g	IRRIGATION	NDA	18 sections
Lactated Ringers Irrigation	HUMAN PRESCRIPTION DRUG LABEL	4	0264-7389	SOLUTION	310 mg	IRRIGATION	NDA	14 sections
Lactated Ringers Irrigation	HUMAN PRESCRIPTION DRUG LABEL	4	0264-7389	SOLUTION	310 mg	IRRIGATION	NDA	14 sections
Lactated Ringers	HUMAN PRESCRIPTION DRUG LABEL	4	0264-7500	INJECTION, SOLUTION	0.31 g	INTRAVENOUS	NDA	23 sections
Lactated Ringers	HUMAN PRESCRIPTION DRUG LABEL	4	0264-7500	INJECTION, SOLUTION	0.31 g	INTRAVENOUS	NDA	23 sections
Lactated Ringers	HUMAN PRESCRIPTION DRUG LABEL	4	0264-7750	INJECTION, SOLUTION	0.31 g	INTRAVENOUS	NDA	23 sections
Lactated Ringers	HUMAN PRESCRIPTION DRUG LABEL	4	0264-7750	INJECTION, SOLUTION	0.31 g	INTRAVENOUS	NDA	23 sections
Lactated Ringers	HUMAN PRESCRIPTION DRUG LABEL	4	0264-7750	INJECTION, SOLUTION	0.31 g	INTRAVENOUS	NDA	23 sections
Lactated Ringers	HUMAN PRESCRIPTION DRUG LABEL	4	0264-7750	INJECTION, SOLUTION	0.31 g	INTRAVENOUS	NDA	23 sections
Dextrose in Lactated Ringers	HUMAN PRESCRIPTION DRUG LABEL	5	0264-7751	INJECTION, SOLUTION	0.31 g	INTRAVENOUS	NDA	22 sections
Lactated Ringers	HUMAN PRESCRIPTION DRUG LABEL	4	0338-0114	IRRIGANT	310 mg	IRRIGATION	NDA	5 sections
Lactated Ringers	HUMAN PRESCRIPTION DRUG LABEL	4	0338-0114	IRRIGANT	310 mg	IRRIGATION	NDA	5 sections
Lactated Ringers	HUMAN PRESCRIPTION DRUG LABEL	4	0338-0114	IRRIGANT	310 mg	IRRIGATION	NDA	5 sections
Lactated Ringers	HUMAN PRESCRIPTION DRUG LABEL	4	0338-0114	IRRIGANT	310 mg	IRRIGATION	NDA	5 sections
Lactated Ringers	HUMAN PRESCRIPTION DRUG LABEL	4	0338-0117	INJECTION, SOLUTION	310 mg	INTRAVENOUS	NDA	19 sections
Lactated Ringers	HUMAN PRESCRIPTION DRUG LABEL	4	0338-0117	INJECTION, SOLUTION	310 mg	INTRAVENOUS	NDA	19 sections
Lactated Ringers	HUMAN PRESCRIPTION DRUG LABEL	4	0338-0117	INJECTION, SOLUTION	310 mg	INTRAVENOUS	NDA	19 sections
Lactated Ringers	HUMAN PRESCRIPTION DRUG LABEL	4	0338-0117	INJECTION, SOLUTION	310 mg	INTRAVENOUS	NDA	19 sections
Lactated Ringers and Dextrose	HUMAN PRESCRIPTION DRUG LABEL	5	0338-0125	INJECTION, SOLUTION	310 mg	INTRAVENOUS	NDA	18 sections
Lactated Ringers and Dextrose	HUMAN PRESCRIPTION DRUG LABEL	5	0338-0125	INJECTION, SOLUTION	310 mg	INTRAVENOUS	NDA	18 sections
Lactated Ringers and Dextrose	HUMAN PRESCRIPTION DRUG LABEL	5	0338-0125	INJECTION, SOLUTION	310 mg	INTRAVENOUS	NDA	18 sections
Lactated Ringers and Dextrose	HUMAN PRESCRIPTION DRUG LABEL	5	0338-0125	INJECTION, SOLUTION	310 mg	INTRAVENOUS	NDA	18 sections
Lactated Ringers	HUMAN PRESCRIPTION DRUG LABEL	4	0338-0137	IRRIGANT	3.10 g	IRRIGATION	NDA	17 sections
Lactated Ringers	HUMAN PRESCRIPTION DRUG LABEL	4	0338-0137	IRRIGANT	3.10 g	IRRIGATION	NDA	17 sections
Lactated Ringers	HUMAN PRESCRIPTION DRUG LABEL	4	0338-0137	IRRIGANT	3.10 g	IRRIGATION	NDA	17 sections
Lactated Ringers	HUMAN PRESCRIPTION DRUG LABEL	4	0338-0137	IRRIGANT	3.10 g	IRRIGATION	NDA	17 sections
Dextrose and Electrolyte No. 48	HUMAN PRESCRIPTION DRUG LABEL	6	0338-0143	INJECTION	260 mg	INTRAVENOUS	NDA	19 sections