magnesium chloride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4200	7786-30-3

Description:

Molecule	Description
Synonyms: magnesium chloride	Magnesium chloride. An inorganic compound consisting of one magnesium and two chloride ions. The compound is used in medicine as a source of magnesium ions, which are essential for many cellular activities. It has also been used as a cathartic and in alloys. Molecular weight: 95.21 Formula: Cl2Mg CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

magnesium chloride

Magnesium chloride. An inorganic compound consisting of one magnesium and two chloride ions. The compound is used in medicine as a source of magnesium ions, which are essential for many cellular activities. It has also been used as a cathartic and in alloys.

Molecular weight: 95.21
Formula: Cl2Mg
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
2.50	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Aug. 13, 1975	FDA	HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Death	700.20	18.73	441	5864	373940	63108777
Peritonitis bacterial	559.71	18.73	123	6182	4756	63477961
Peritonitis	376.37	18.73	116	6189	17038	63465679
Peritoneal dialysis complication	356.61	18.73	67	6238	1153	63481564
Toxic anterior segment syndrome	343.63	18.73	69	6236	1702	63481015
Fungal peritonitis	232.24	18.73	41	6264	488	63482229
Device interaction	171.94	18.73	28	6277	196	63482521
Sepsis	154.50	18.73	125	6180	152998	63329719
Endophthalmitis	135.21	18.73	37	6268	3555	63479162
Ultrafiltration failure	96.76	18.73	17	6288	196	63482521
Encapsulating peritoneal sclerosis	94.56	18.73	18	6287	332	63482385
Peritoneal cloudy effluent	68.81	18.73	12	6293	132	63482585
Hypervolaemia	66.35	18.73	39	6266	28374	63454343
Cardiac disorder	54.29	18.73	43	6262	50773	63431944
Cardiovascular disorder	52.70	18.73	25	6280	11787	63470930
Post procedural complication	52.27	18.73	28	6277	17046	63465671
Tonsillar haemorrhage	49.59	18.73	10	6295	251	63482466
Myocardial infarction	49.28	18.73	55	6250	99838	63382879
Cardiac arrest	49.21	18.73	53	6252	92492	63390225
Anterior chamber inflammation	47.34	18.73	10	6295	317	63482400
Drug ineffective	43.67	18.73	25	6280	1044740	62437977
Bloody peritoneal effluent	41.93	18.73	7	6298	58	63482659
Cardiac failure	40.43	18.73	47	6258	89095	63393622
Gangrene	40.25	18.73	17	6288	6106	63476611
Marasmus	37.42	18.73	9	6296	516	63482201
Cataract operation complication	36.57	18.73	7	6298	133	63482584
Cerebrovascular accident	34.76	18.73	48	6257	107976	63374741
Hypoglycaemia	34.75	18.73	36	6269	60029	63422688
Anterior chamber disorder	30.91	18.73	6	6299	123	63482594
Diabetic complication	27.94	18.73	8	6297	905	63481812
Hypoglycaemic coma	26.93	18.73	10	6295	2565	63480152
Pulmonary oedema	26.67	18.73	30	6275	54843	63427874
Noninfectious peritonitis	24.37	18.73	5	6300	137	63482580
Pneumonia	23.07	18.73	98	6207	456669	63026048
Abdominal distension	22.78	18.73	35	6270	86580	63396137
Hypotension	22.77	18.73	69	6236	272535	63210182
Dermatitis exfoliative	22.66	18.73	11	6294	5448	63477269
Joint swelling	22.46	18.73	3	6302	327663	63155054
Drug intolerance	20.74	18.73	3	6302	308658	63174059
Catheter site infection	20.70	18.73	10	6295	4904	63477813
Diabetic foot	20.35	18.73	7	6298	1440	63481277
Corneal oedema	20.14	18.73	7	6298	1486	63481231
Amylase abnormal	19.83	18.73	3	6302	12	63482705
Blood glucose false positive	19.83	18.73	3	6302	12	63482705
Faeces soft	19.30	18.73	10	6295	5682	63477035

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Peritonitis bacterial	786.68	23.66	190	6307	5920	34944514
Death	749.83	23.66	599	5898	397450	34552984
Peritonitis	490.99	23.66	163	6334	16202	34934232
Peritoneal dialysis complication	470.53	23.66	99	6398	1610	34948824
Fungal peritonitis	325.98	23.66	64	6433	719	34949715
Toxic anterior segment syndrome	283.39	23.66	61	6436	1108	34949326
Device interaction	138.94	23.66	30	6467	552	34949882
Cardiac disorder	114.79	23.66	81	6416	43045	34907389
Myocardial infarction	114.38	23.66	126	6371	120959	34829475
Encapsulating peritoneal sclerosis	110.93	23.66	25	6472	564	34949870
Ultrafiltration failure	109.91	23.66	20	6477	143	34950291
Cardiac failure	94.93	23.66	100	6397	91148	34859286
Gangrene	92.27	23.66	34	6463	4552	34945882
Peritoneal cloudy effluent	83.41	23.66	16	6481	157	34950277
Hypervolaemia	81.90	23.66	49	6448	19660	34930774
Noninfectious peritonitis	81.17	23.66	15	6482	118	34950316
Cardiac arrest	80.37	23.66	94	6403	96065	34854369
Post procedural complication	76.86	23.66	39	6458	11349	34939085
Sepsis	74.16	23.66	120	6377	166441	34783993
Endophthalmitis	70.53	23.66	26	6471	3482	34946952
Cardiovascular disorder	58.00	23.66	31	6466	10025	34940409
Catheter site infection	55.00	23.66	20	6477	2577	34947857
Drug ineffective	51.84	23.66	11	6486	456740	34493694
Cataract operation complication	47.85	23.66	10	6487	156	34950278
Bloody peritoneal effluent	45.57	23.66	9	6488	104	34950330
Peritoneal effluent abnormal	38.35	23.66	7	6490	51	34950383
Hernia	32.62	23.66	21	6476	9562	34940872
Blood glucose false positive	32.37	23.66	6	6491	48	34950386
Cerebrovascular accident	32.16	23.66	57	6440	84754	34865680
Procedural pain	28.22	23.66	15	6482	4791	34945643
Localised infection	27.15	23.66	24	6473	17563	34932871
Peritoneal disorder	27.15	23.66	7	6490	282	34950152
Drug interaction	26.46	23.66	5	6492	225941	34724493
Keratitis	26.41	23.66	10	6487	1441	34948993
Complication associated with device	25.10	23.66	15	6482	5991	34944443
Toxicity to various agents	24.40	23.66	4	6493	200358	34750076
Procedural complication	24.12	23.66	13	6484	4270	34946164
Peritoneal effluent leukocyte count increased	23.93	23.66	4	6493	16	34950418
Hypoglycaemia	23.70	23.66	39	6458	54601	34895833

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Peritonitis bacterial	1064.75	18.51	240	8630	9327	79726191
Toxic anterior segment syndrome	561.43	18.51	114	8756	2650	79732868
Peritonitis	554.91	18.51	180	8690	27856	79707662
Peritoneal dialysis complication	495.35	18.51	100	8770	2254	79733264
Death	447.05	18.51	420	8450	566094	79169424
Fungal peritonitis	336.98	18.51	64	8806	1036	79734482
Device interaction	244.58	18.51	46	8824	704	79734814
Endophthalmitis	197.86	18.51	58	8812	6370	79729148
Encapsulating peritoneal sclerosis	166.21	18.51	34	8836	817	79734701
Sepsis	108.02	18.51	141	8729	269287	79466231
Ultrafiltration failure	104.17	18.51	19	8851	243	79735275
Peritoneal cloudy effluent	99.28	18.51	19	8851	320	79735198
Cardiac arrest	94.99	18.51	106	8764	171990	79563528
Post procedural complication	93.80	18.51	48	8822	23781	79711737
Cataract operation complication	88.96	18.51	17	8853	284	79735234
Gangrene	87.06	18.51	34	8836	8930	79726588
Hypervolaemia	74.94	18.51	51	8819	42639	79692879
Noninfectious peritonitis	72.75	18.51	14	8856	243	79735275
Myocardial infarction	70.03	18.51	94	8776	184035	79551483
Cardiac disorder	63.41	18.51	55	8815	65702	79669816
Drug ineffective	58.09	18.51	24	8846	1080889	78654629
Blood glucose false positive	57.16	18.51	9	8861	43	79735475
Bloody peritoneal effluent	52.16	18.51	10	8860	170	79735348
Catheter site infection	46.29	18.51	20	8850	6775	79728743
Cardiac failure	45.54	18.51	70	8800	154772	79580746
Complication associated with device	40.80	18.51	25	8845	17471	79718047
Hypoglycaemia	40.31	18.51	53	8817	101541	79633977
Peritoneal effluent abnormal	36.81	18.51	6	8864	37	79735481
Abdominal distension	36.45	18.51	55	8815	119595	79615923
Anterior chamber disorder	34.76	18.51	7	8863	155	79735363
Peritoneal disorder	33.40	18.51	9	8861	726	79734792
Diabetic complication	32.67	18.51	10	8860	1269	79734249
Procedural complication	31.16	18.51	16	8854	7967	79727551
Tonsillar haemorrhage	30.51	18.51	7	8863	291	79735227
Drug interaction	30.16	18.51	5	8865	415178	79320340
Toxicity to various agents	28.65	18.51	6	8864	421534	79313984
Regurgitation	28.58	18.51	11	8859	2776	79732742
Pneumonia	28.06	18.51	146	8724	660100	79075418
Rash pruritic	26.31	18.51	36	8834	71593	79663925
Hypoglycaemic coma	25.99	18.51	12	8858	4748	79730770
Rash erythematous	25.84	18.51	32	8838	57737	79677781
Keratitis	23.92	18.51	11	8859	4311	79731207
Blood loss anaemia	23.64	18.51	17	8853	15481	79720037
Lactobacillus test positive	23.52	18.51	4	8866	33	79735485
Multimorbidity	23.46	18.51	8	8862	1431	79734087
Haemodialysis	23.40	18.51	18	8852	18150	79717368
Corneal disorder	23.34	18.51	9	8861	2282	79733236
Cerebrovascular accident	22.65	18.51	52	8818	155240	79580278
Staphylococcal infection	22.47	18.51	30	8840	58265	79677253
Corneal oedema	22.17	18.51	9	8861	2611	79732907
Device related infection	22.16	18.51	23	8847	34271	79701247
Amylase abnormal	21.87	18.51	4	8866	52	79735466
Peritoneal fluid analysis abnormal	21.59	18.51	4	8866	56	79735462
Ileus	21.45	18.51	20	8850	26191	79709327
Failure to thrive	20.41	18.51	14	8856	11830	79723688
Hypotension	19.79	18.51	99	8771	440218	79295300
Dermatitis exfoliative	19.14	18.51	13	8857	10816	79724702
Product complaint	18.91	18.51	14	8856	13335	79722183
Intraocular pressure increased	18.57	18.51	12	8858	9193	79726325

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A12CC01	ALIMENTARY TRACT AND METABOLISM MINERAL SUPPLEMENTS OTHER MINERAL SUPPLEMENTS Magnesium
ATC	B05XA11	BLOOD AND BLOOD FORMING ORGANS BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS I.V. SOLUTION ADDITIVES Electrolyte solutions

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypomagnesemia	indication	190855004
Anuria	contraindication	2472002	DOID:2983
Hypocalcemia	contraindication	5291005
Classical phenylketonuria	contraindication	7573000
Poisoning by digitalis glycoside	contraindication	12876009
Hyperkalemia	contraindication	14140009
Complete atrioventricular block	contraindication	27885002
Sarcoidosis	contraindication	31541009	DOID:11335
End stage renal disease	contraindication	46177005	DOID:784
Humoral hypercalcemia of malignancy	contraindication	47709007
Heart disease	contraindication	56265001	DOID:114
Congenital myotonia, autosomal dominant form	contraindication	57938005
Acute nephropathy	contraindication	58574008
Diarrhea	contraindication	62315008
Hypercalcemia	contraindication	66931009	DOID:12678
Hypermagnesemia	contraindication	66978005
Ventricular fibrillation	contraindication	71908006
Hypercalciuria	contraindication	71938000
Hyperchloremia	contraindication	74450001
Third degree burn injury	contraindication	80247002
Oliguria	contraindication	83128009
Kidney disease	contraindication	90708001	DOID:557
Kidney stone	contraindication	95570007
Hyporeninemic hypoaldosteronism	contraindication	236464008
Familial hyperkalemic periodic paralysis	contraindication	304737009	DOID:14451
Azotemia	contraindication	445009001
Severe dehydration	contraindication	450316000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
0.21GM/100ML;2.8GM/100ML;9.07GM/100ML	NORMOCARB HF 25	DIALYSIS SUPS	N021910	July 26, 2006	RX	SOLUTION	INJECTION	7300674	March 4, 2023	USE AS REPLACEMENT SOLUTION, HEMOFILTRATION SOLUTION OR HEMODIAFILTRATION SOLUTION IN CONTINUOUS RENAL REPLACEMENT THERAPY

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4018213	VUID
N0000146546	NUI
D04834	KEGG_DRUG
4018213	VANDF
C0024472	UMLSCUI
CHEBI:86345	CHEBI
CHEMBL2219642	ChEMBL_ID
CHEMBL3185229	ChEMBL_ID
D015636	MESH_DESCRIPTOR_UI
DB09407	DRUGBANK_ID
02F3473H9O	UNII
6579	RXNORM
5007	MMSL
5009	MMSL
71973	MMSL
d03796	MMSL
000786	NDDF
45733002	SNOMEDCT_US
768454005	SNOMEDCT_US
7791-18-6	SECONDARY_CAS_RN

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
BSS	HUMAN PRESCRIPTION DRUG LABEL	6	0065-0795	SOLUTION	0.30 mg	OPHTHALMIC	NDA	9 sections
BSS	HUMAN PRESCRIPTION DRUG LABEL	6	0065-0795	SOLUTION	0.30 mg	OPHTHALMIC	NDA	9 sections
BSS	HUMAN PRESCRIPTION DRUG LABEL	6	0065-0795	SOLUTION	0.30 mg	OPHTHALMIC	NDA	9 sections
BSS	HUMAN PRESCRIPTION DRUG LABEL	6	0065-0795	SOLUTION	0.30 mg	OPHTHALMIC	NDA	9 sections
BSS	HUMAN PRESCRIPTION DRUG LABEL	6	0065-1795	SOLUTION	0.30 mg	OPHTHALMIC	NDA	9 sections
BSS	HUMAN PRESCRIPTION DRUG LABEL	6	0065-1795	SOLUTION	0.30 mg	OPHTHALMIC	NDA	9 sections
HyperlyteCR	HUMAN PRESCRIPTION DRUG LABEL	5	0264-1943	INJECTION, SOLUTION, CONCENTRATE	0.51 g	INTRAVENOUS	UNAPPROVED DRUG OTHER	18 sections
HyperlyteCR	HUMAN PRESCRIPTION DRUG LABEL	5	0264-1943	INJECTION, SOLUTION, CONCENTRATE	0.51 g	INTRAVENOUS	UNAPPROVED DRUG OTHER	18 sections
Balanced Salt	HUMAN PRESCRIPTION DRUG LABEL	6	0264-1945	SOLUTION	0.30 mg	IRRIGATION	ANDA	11 sections
Physiolyte	HUMAN PRESCRIPTION DRUG LABEL	5	0264-2205	IRRIGANT	0.03 g	IRRIGATION	NDA	20 sections
Physiolyte	HUMAN PRESCRIPTION DRUG LABEL	5	0264-2205	IRRIGANT	0.03 g	IRRIGATION	NDA	20 sections
Physiolyte	HUMAN PRESCRIPTION DRUG LABEL	5	0264-2205	IRRIGANT	0.03 g	IRRIGATION	NDA	20 sections
Physiolyte	HUMAN PRESCRIPTION DRUG LABEL	5	0264-2205	IRRIGANT	0.03 g	IRRIGATION	NDA	20 sections
Balanced Salt	HUMAN PRESCRIPTION DRUG LABEL	6	0264-2514	SOLUTION	0.30 mg	IRRIGATION	ANDA	11 sections
Isolyte S	HUMAN PRESCRIPTION DRUG LABEL	5	0264-7703	INJECTION, SOLUTION	0.03 g	INTRAVENOUS	NDA	19 sections
Isolyte S	HUMAN PRESCRIPTION DRUG LABEL	5	0264-7703	INJECTION, SOLUTION	0.03 g	INTRAVENOUS	NDA	19 sections
Isolyte S pH 7.4	HUMAN PRESCRIPTION DRUG LABEL	7	0264-7707	INJECTION, SOLUTION	0.03 g	INTRAVENOUS	NDA	24 sections
Isolyte S pH 7.4	HUMAN PRESCRIPTION DRUG LABEL	7	0264-7707	INJECTION, SOLUTION	0.03 g	INTRAVENOUS	NDA	24 sections
Isolyte S pH 7.4	HUMAN PRESCRIPTION DRUG LABEL	7	0264-7707	INJECTION, SOLUTION	0.03 g	INTRAVENOUS	NDA	24 sections
Isolyte S pH 7.4	HUMAN PRESCRIPTION DRUG LABEL	7	0264-7707	INJECTION, SOLUTION	0.03 g	INTRAVENOUS	NDA	24 sections
Isolyte P in Dextrose	HUMAN PRESCRIPTION DRUG LABEL	5	0264-7730	INJECTION, SOLUTION	0.03 g	INTRAVENOUS	NDA	23 sections
Isolyte P in Dextrose	HUMAN PRESCRIPTION DRUG LABEL	5	0264-7730	INJECTION, SOLUTION	0.03 g	INTRAVENOUS	NDA	23 sections
Isolyte P in Dextrose	HUMAN PRESCRIPTION DRUG LABEL	5	0264-7730	INJECTION, SOLUTION	0.03 g	INTRAVENOUS	NDA	23 sections
Isolyte P in Dextrose	HUMAN PRESCRIPTION DRUG LABEL	5	0264-7730	INJECTION, SOLUTION	0.03 g	INTRAVENOUS	NDA	23 sections
Dextrose and Electrolyte No. 48	HUMAN PRESCRIPTION DRUG LABEL	6	0338-0143	INJECTION	31 mg	INTRAVENOUS	NDA	19 sections
Dextrose and Electrolyte No. 48	HUMAN PRESCRIPTION DRUG LABEL	6	0338-0143	INJECTION	31 mg	INTRAVENOUS	NDA	19 sections
Dextrose and Electrolyte No. 48	HUMAN PRESCRIPTION DRUG LABEL	6	0338-0143	INJECTION	31 mg	INTRAVENOUS	NDA	19 sections
Dextrose and Electrolyte No. 48	HUMAN PRESCRIPTION DRUG LABEL	6	0338-0143	INJECTION	31 mg	INTRAVENOUS	NDA	19 sections
Plasma-Lyte 148	HUMAN PRESCRIPTION DRUG LABEL	5	0338-0179	INJECTION, SOLUTION	30 mg	INTRAVENOUS	NDA	20 sections
Plasma-Lyte 148	HUMAN PRESCRIPTION DRUG LABEL	5	0338-0179	INJECTION, SOLUTION	30 mg	INTRAVENOUS	NDA	20 sections