sodium chloride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4198 7647-14-5

Description:

MoleculeDescription

Synonyms:

  • sodium chloride
A ubiquitous sodium salt that is commonly used to season food.
  • Molecular weight: 58.44
  • Formula: ClNa
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
1 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 16, 1965 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myelosuppression 1281.28 10.00 567 84538 12950 50507069
Infective pulmonary exacerbation of cystic fibrosis 795.43 10.00 346 84759 7563 50512456
Agranulocytosis 609.38 10.00 404 84701 21017 50499002
Bone marrow failure 558.64 10.00 423 84682 27201 50492818
Hereditary angioedema 444.84 10.00 206 84899 5236 50514783
Hyperchloraemia 327.61 10.00 96 85009 605 50519414
Peritonitis bacterial 248.66 10.00 132 84973 4529 50515490
Rheumatoid arthritis 235.90 10.00 31 85074 202519 50317500
Drug ineffective 230.72 10.00 666 84439 818667 49701352
Drug intolerance 227.38 10.00 46 85059 219058 50300961
Joint swelling 215.51 10.00 72 85033 245214 50274805
Contraindicated product administered 215.30 10.00 8 85097 148950 50371069
Cystic fibrosis 214.27 10.00 102 85003 2762 50517257
White blood cell count decreased 206.50 10.00 543 84562 116179 50403840
Chills 196.31 10.00 474 84631 96213 50423806
Synovitis 184.91 10.00 5 85100 123860 50396159
Completed suicide 184.23 10.00 9 85096 131880 50388139
Arthropathy 179.48 10.00 26 85079 157880 50362139
Systemic lupus erythematosus 177.68 10.00 16 85089 140606 50379413
Peritoneal dialysis complication 170.75 10.00 67 85038 1114 50518905
Chest discomfort 169.73 10.00 437 84668 92285 50427734
Toxic anterior segment syndrome 159.04 10.00 69 85036 1496 50518523
Treatment failure 155.62 10.00 23 85082 137614 50382405
Alopecia 153.42 10.00 113 84992 244934 50275085
Therapeutic product effect decreased 153.21 10.00 23 85082 136027 50383992
Pyrexia 137.99 10.00 1101 84004 379102 50140917
Glossodynia 129.06 10.00 20 85085 115549 50404470
Leukopenia 125.32 10.00 320 84785 67208 50452811
Neutrophil count decreased 123.04 10.00 252 84853 45774 50474245
Fungal peritonitis 119.45 10.00 41 85064 456 50519563
Arthralgia 111.85 10.00 372 84733 438330 50081689
Peritonitis 109.98 10.00 133 84972 15353 50504666
Sepsis 105.42 10.00 473 84632 132452 50387567
Macular degeneration 104.52 10.00 125 84980 14263 50505756
Hepatic function abnormal 103.24 10.00 192 84913 32489 50487530
Drug hypersensitivity 100.66 10.00 167 84938 250843 50269176
Pericarditis 96.60 10.00 10 85095 78679 50441340
Hyponatraemia 95.77 10.00 367 84738 95772 50424247
Device interaction 93.39 10.00 28 85077 193 50519826
Hyperpyrexia 90.28 10.00 59 85046 2990 50517029
Vomiting 85.84 10.00 1165 83940 459593 50060426
Pain 84.95 10.00 598 84507 578305 49941714
Musculoskeletal stiffness 83.27 10.00 57 85048 128424 50391595
Wound 82.93 10.00 37 85068 105757 50414262
Swelling 79.23 10.00 135 84970 200737 50319282
Death 78.89 10.00 865 84240 324514 50195505
Hospitalisation 75.74 10.00 269 84836 67668 50452351
Toxicity to various agents 73.13 10.00 155 84950 212344 50307675
Flushing 72.70 10.00 263 84842 66752 50453267
Infusion site extravasation 72.21 10.00 73 85032 6903 50513116
Incorrect drug administration rate 71.28 10.00 48 85057 2558 50517461
Hyponatraemic encephalopathy 70.96 10.00 23 85082 211 50519808
Abdominal discomfort 70.08 10.00 181 84924 231460 50288559
Sinusitis 70.06 10.00 509 84596 170049 50349970
Infusion site coldness 68.85 10.00 22 85083 192 50519827
Temperature intolerance 67.49 10.00 73 85032 7466 50512553
Hypernatraemia 67.00 10.00 67 85038 6254 50513765
Hepatic enzyme increased 66.33 10.00 80 85025 137300 50382719
Dyspnoea 65.46 10.00 1287 83818 546321 49973698
Pantoea agglomerans infection 65.45 10.00 15 85090 27 50519992
Pneumonia 65.19 10.00 944 84161 377457 50142562
Extravasation 64.86 10.00 41 85064 1961 50518058
Infusion site pain 64.26 10.00 91 85014 12255 50507764
Granulocytopenia 62.10 10.00 59 85046 5172 50514847
Gamma-glutamyltransferase decreased 60.79 10.00 22 85083 289 50519730
Incorrect route of product administration 60.62 10.00 111 84994 18555 50501464
Gadolinium deposition disease 59.64 10.00 15 85090 47 50519972
Product use issue 57.51 10.00 102 85003 149373 50370646
Tachypnoea 56.88 10.00 94 85011 14483 50505536
Febrile neutropenia 56.48 10.00 318 84787 97349 50422670
Cystic fibrosis respiratory infection suppression 55.45 10.00 20 85085 260 50519759
Endophthalmitis 55.27 10.00 43 85062 2873 50517146
Hypokalaemia 55.25 10.00 293 84812 87699 50432320
Infusion site swelling 54.86 10.00 64 85041 7112 50512907
Cytokine release syndrome 54.65 10.00 70 85035 8564 50511455
Infusion site erythema 54.05 10.00 70 85035 8657 50511362
Psoriatic arthropathy 52.80 10.00 8 85097 47024 50472995
Psoriasis 52.71 10.00 25 85080 68975 50451044
Helicobacter infection 52.39 10.00 10 85095 49692 50470327
Pulmonary function test decreased 51.65 10.00 44 85061 3344 50516675
Burkholderia cepacia complex infection 51.41 10.00 16 85089 127 50519892
Mobility decreased 51.07 10.00 36 85069 79912 50440107
Infusion related reaction 50.72 10.00 471 84634 169086 50350933
Osmotic demyelination syndrome 49.92 10.00 23 85082 577 50519442
Blood pressure decreased 49.67 10.00 206 84899 55703 50464316
Discomfort 48.29 10.00 67 85038 108313 50411706
Acidosis hyperchloraemic 48.25 10.00 19 85086 319 50519700
Folliculitis 48.09 10.00 5 85100 39220 50480799
Infusion site induration 47.34 10.00 25 85080 848 50519171
Drug interaction 46.86 10.00 175 84930 199446 50320573
Drug abuse 46.77 10.00 21 85084 59825 50460194
Hypervolaemia 46.40 10.00 120 84985 25379 50494640
Cardiac arrest 46.15 10.00 269 84836 83382 50436637
Ultrafiltration failure 45.98 10.00 16 85089 186 50519833
Loss of personal independence in daily activities 45.46 10.00 31 85074 70019 50450000
Encapsulating peritoneal sclerosis 44.77 10.00 18 85087 320 50519699
Therapeutic product effect incomplete 44.47 10.00 53 85052 91462 50428557
Arthritis 43.45 10.00 49 85056 86672 50433347
Suspected transmission of an infectious agent via product 43.28 10.00 16 85089 224 50519795
Anaphylactic shock 42.11 10.00 100 85005 20055 50499964
Nausea 41.98 10.00 1513 83592 703885 49816134
Wound infection pseudomonas 41.06 10.00 26 85079 1247 50518772
Anterior chamber inflammation 40.18 10.00 16 85089 277 50519742
Lymphatic fistula 39.32 10.00 21 85084 729 50519290
Femoral hernia incarcerated 39.04 10.00 21 85084 740 50519279
Sleep disorder due to general medical condition, insomnia type 38.57 10.00 4 85101 31443 50488576
Product preparation error 38.55 10.00 42 85063 4330 50515689
Device related infection 38.16 10.00 98 85007 20637 50499382
Pallor 37.99 10.00 105 85000 23094 50496925
Infusion site haemorrhage 37.80 10.00 35 85070 2969 50517050
Upper respiratory tract infection 37.71 10.00 214 84891 65684 50454335
Urinary tract infection 37.33 10.00 556 84549 223464 50296555
Peritoneal cloudy effluent 36.54 10.00 11 85094 77 50519942
Intentional overdose 36.30 10.00 31 85074 62473 50457546
Cardiovascular disorder 36.29 10.00 64 85041 10390 50509629
Therapeutic response decreased 36.25 10.00 17 85088 47214 50472805
Condition aggravated 35.90 10.00 323 84782 296735 50223284
Product contamination 35.75 10.00 18 85087 552 50519467
Pancreatic steatosis 35.13 10.00 21 85084 908 50519111
Cyanosis 34.65 10.00 78 85027 15106 50504913
Suspected product quality issue 34.53 10.00 13 85092 192 50519827
Peripheral swelling 34.48 10.00 204 84901 205732 50314287
Bacteraemia 33.90 10.00 75 85030 14358 50505661
Post-traumatic neck syndrome 33.70 10.00 27 85078 1883 50518136
Maternal exposure during pregnancy 32.52 10.00 148 84957 159630 50360389
Abdominal distension 32.47 10.00 222 84883 72681 50447338
Insomnia 32.11 10.00 168 84937 174697 50345322
Sputum increased 32.11 10.00 26 85079 1841 50518178
Osteoarthritis 31.99 10.00 41 85064 68565 50451454
Irritable bowel syndrome 31.76 10.00 24 85081 51417 50468602
Poor venous access 31.71 10.00 60 85045 10280 50509739
Maternal exposure during delivery 31.09 10.00 20 85085 986 50519033
Haemodialysis complication 31.06 10.00 12 85093 191 50519828
Knee arthroplasty 30.59 10.00 11 85094 35835 50484184
Stomatitis 29.98 10.00 80 85025 101264 50418755
Unresponsive to stimuli 29.75 10.00 116 84989 30493 50489526
Suicide attempt 29.62 10.00 26 85079 51706 50468313
Arterial haemorrhage 29.60 10.00 23 85082 1534 50518485
Hepatorenal failure 29.15 10.00 16 85089 587 50519432
Vein disorder 28.89 10.00 36 85069 4283 50515736
Hypotension 28.83 10.00 556 84549 234913 50285106
Blood creatine increased 28.41 10.00 38 85067 4849 50515170
Hip arthroplasty 28.34 10.00 8 85097 30421 50489598
Haemoptysis 28.26 10.00 101 85004 25472 50494547
Dehydration 28.01 10.00 385 84720 152064 50367955
Headache 27.73 10.00 1077 84028 505458 50014561
Therapy non-responder 27.61 10.00 27 85078 50995 50469024
Hypoxia 27.28 10.00 163 84942 50960 50469059
Excessive eye blinking 27.26 10.00 18 85087 928 50519091
COVID-19 27.00 10.00 152 84953 46510 50473509
Product compounding quality issue 26.71 10.00 7 85098 27 50519992
Fatigue 26.59 10.00 949 84156 706652 49813367
Weight increased 26.38 10.00 215 84890 201676 50318343
Acute respiratory failure 26.30 10.00 107 84998 28675 50491344
Seroma 26.22 10.00 23 85082 1818 50518201
Respiratory failure 26.09 10.00 251 84854 90930 50429089
Gait disturbance 25.95 10.00 147 84958 149858 50370161
Laryngospasm 25.78 10.00 27 85078 2661 50517358
Burkholderia test positive 25.76 10.00 11 85094 229 50519790
Cystic fibrosis lung 25.76 10.00 9 85096 106 50519913
Vasodilatation 25.72 10.00 25 85080 2254 50517765
Cough 25.68 10.00 558 84547 240706 50279313
Mental status changes postoperative 25.12 10.00 10 85095 173 50519846
Urticaria 24.95 10.00 330 84775 129231 50390788
C-reactive protein abnormal 24.65 10.00 8 85097 27801 50492218
Anaphylactic reaction 24.30 10.00 165 84940 53890 50466129
Pulmonary oedema 24.20 10.00 153 84952 48785 50471234
Disorganised speech 24.15 10.00 17 85088 974 50519045
Disturbance in social behaviour 24.13 10.00 27 85078 2867 50517152
Ill-defined disorder 24.12 10.00 34 85071 54620 50465399
Confusion postoperative 24.12 10.00 10 85095 193 50519826
Ear infection 24.09 10.00 97 85008 25873 50494146
Blister 24.09 10.00 69 85036 85349 50434670
Depression 24.05 10.00 171 84934 165252 50354767
Respiratory tract infection 23.89 10.00 112 84993 31905 50488114
Bloody peritoneal effluent 23.38 10.00 7 85098 48 50519971
Cytopenia 23.38 10.00 48 85057 8727 50511292
Acute pulmonary oedema 23.32 10.00 43 85062 7224 50512795
Staphylococcal infection 23.30 10.00 120 84985 35496 50484523
Osteonecrosis of jaw 23.03 10.00 13 85092 32513 50487506
Suspected product contamination 22.72 10.00 6 85099 24 50519995
Obstetric procedure complication 22.58 10.00 5 85100 7 50520012
Product preparation issue 22.58 10.00 14 85091 647 50519372
Peripheral coldness 22.55 10.00 52 85053 10231 50509788
Nephrocalcinosis 22.11 10.00 16 85089 958 50519061
Product deposit 22.08 10.00 9 85096 166 50519853
Blood creatinine decreased 22.04 10.00 34 85071 4942 50515077
Red blood cell sedimentation rate increased 21.94 10.00 11 85094 29405 50490614
Osteoporosis 21.78 10.00 26 85079 44853 50475166
Intentional self-injury 21.66 10.00 6 85099 23106 50496913
Poor quality product administered 21.31 10.00 25 85080 2794 50517225
Type 2 diabetes mellitus 21.27 10.00 16 85089 34359 50485660
Oxygen saturation decreased 21.13 10.00 202 84903 73046 50446973
Extradural haematoma 20.96 10.00 19 85086 1568 50518451
Rapid correction of hyponatraemia 20.96 10.00 8 85097 123 50519896
Post procedural complication 20.55 10.00 64 85041 15040 50504979
Pulse abnormal 20.37 10.00 20 85085 1825 50518194
Aortic valve stenosis 20.23 10.00 25 85080 2950 50517069
Pseudomonas infection 19.93 10.00 47 85058 9383 50510636
Haemolysis 19.82 10.00 36 85069 5980 50514039
Mean cell haemoglobin decreased 19.56 10.00 26 85079 3297 50516722
Marasmus 19.43 10.00 11 85094 429 50519590
Neutropenic sepsis 19.30 10.00 60 85045 14087 50505932
Septic shock 19.21 10.00 163 84942 57012 50463007
Anaphylactoid reaction 19.06 10.00 26 85079 3380 50516639
Pain in extremity 18.88 10.00 334 84771 272531 50247488
Fibromyalgia 18.85 10.00 29 85076 44949 50475070
Procedural complication 18.68 10.00 31 85074 4792 50515227
Balance disorder 18.48 10.00 59 85046 70531 50449488
Inflammation 18.32 10.00 43 85062 56869 50463150
Lower respiratory tract infection 18.29 10.00 90 85015 95111 50424908
Moaning 18.22 10.00 13 85092 761 50519258
Tachyarrhythmia 18.11 10.00 28 85077 4077 50515942
Sinus operation 18.01 10.00 18 85087 1678 50518341
Cataract operation complication 17.86 10.00 7 85098 116 50519903
Back pain 17.72 10.00 490 84615 219540 50300479
Suicidal ideation 17.71 10.00 42 85063 55343 50464676
Illness 17.70 10.00 85 85020 24455 50495564
Memory impairment 17.68 10.00 71 85034 79289 50440730
Cardiogenic shock 17.57 10.00 62 85043 15537 50504482
Haemarthrosis 17.50 10.00 23 85082 2885 50517134
Decreased appetite 17.48 10.00 452 84653 200471 50319548
Product contamination microbial 17.32 10.00 8 85097 202 50519817
Platelet count decreased 17.13 10.00 251 84854 100475 50419544
Wound dehiscence 17.00 10.00 28 85077 4302 50515717
Sinus tachycardia 16.90 10.00 76 85029 21278 50498741
Infusion site bruising 16.76 10.00 20 85085 2275 50517744
Injection site reaction 16.76 10.00 37 85068 49995 50470024
Air embolism 16.66 10.00 8 85097 221 50519798
Anterior chamber disorder 16.36 10.00 6 85099 82 50519937
Infective exacerbation of bronchiectasis 16.35 10.00 9 85096 332 50519687
Diabetes insipidus 16.29 10.00 20 85085 2344 50517675
Perineal cellulitis 16.17 10.00 3 85102 0 50520019
Product barcode issue 16.17 10.00 3 85102 0 50520019
Rash 16.06 10.00 588 84517 436883 50083136
Mental status changes 15.87 10.00 110 84995 36162 50483857
Haematuria 15.86 10.00 85 85020 25528 50494491
Femur fracture 15.85 10.00 24 85081 37440 50482579
Infusion site thrombosis 15.79 10.00 6 85099 91 50519928
Distal intestinal obstruction syndrome 15.78 10.00 9 85096 356 50519663
Abortion spontaneous 15.60 10.00 29 85076 41743 50478276
Acidosis 15.49 10.00 45 85060 10182 50509837
Leukostasis syndrome 15.41 10.00 5 85100 46 50519973
Lip erosion 15.29 10.00 12 85093 812 50519207
Ileus 15.26 10.00 53 85052 13176 50506843
Corneal oedema 15.25 10.00 15 85090 1372 50518647
Laryngeal oedema 15.10 10.00 29 85076 5024 50514995
Epilepsy 15.05 10.00 74 85031 21493 50498526
Stenotrophomonas test positive 14.95 10.00 4 85101 17 50520002
Administration site extravasation 14.47 10.00 11 85094 710 50519309
Blood sodium decreased 14.36 10.00 72 85033 21075 50498944
Feeling cold 14.34 10.00 68 85037 19463 50500556
Disseminated intravascular coagulation 14.33 10.00 62 85043 17073 50502946
Haemodilution 14.32 10.00 6 85099 119 50519900
Pneumothorax 14.30 10.00 54 85051 13980 50506039
Metabolic acidosis 14.29 10.00 113 84992 38712 50481307
Oliguria 14.26 10.00 38 85067 8178 50511841
Anaesthetic complication 14.19 10.00 16 85089 1714 50518305
Adverse event 14.14 10.00 33 85072 43730 50476289
Bursitis 14.09 10.00 10 85095 22125 50497894
Meningitis aseptic 13.87 10.00 25 85080 4127 50515892
Infusion site rash 13.81 10.00 14 85091 1328 50518691
Tachycardia 13.73 10.00 240 84865 99523 50420496
Hepatocellular injury 13.73 10.00 14 85091 25933 50494086
Eyelid oedema 13.71 10.00 41 85064 9425 50510594
Neonatal infection 13.71 10.00 6 85099 133 50519886
Immune effector cell-associated neurotoxicity syndrome 13.70 10.00 13 85092 1137 50518882
Pelvic fluid collection 13.67 10.00 11 85094 772 50519247
Fungal sepsis 13.67 10.00 13 85092 1141 50518878
Tracheitis 13.66 10.00 11 85094 773 50519246
Exposure via contaminated device 13.63 10.00 3 85102 4 50520015
Pharyngitis streptococcal 13.57 10.00 39 85066 8769 50511250
Electrolyte imbalance 13.50 10.00 61 85044 17108 50502911
Faecaloma 13.50 10.00 34 85071 7074 50512945
Cold sweat 13.48 10.00 44 85061 10600 50509419
Lymphocyte count decreased 13.47 10.00 83 85022 26224 50493795
Impaired healing 13.39 10.00 66 85039 69720 50450299
Product administration error 13.32 10.00 67 85038 19632 50500387
Infusion site mass 13.31 10.00 13 85092 1179 50518840
Catheter site infection 13.30 10.00 25 85080 4261 50515758
Myocardial reperfusion injury 13.29 10.00 4 85101 28 50519991
Hyperkalaemia 13.07 10.00 131 84974 47958 50472061
Product container issue 13.05 10.00 14 85091 1418 50518601
Catheter site pain 13.02 10.00 23 85082 3739 50516280
Gangrene 12.90 10.00 26 85079 4666 50515353
Chest pain 12.88 10.00 389 84716 176493 50343526
Rhinovirus infection 12.74 10.00 22 85083 3512 50516507
Hypoalbuminaemia 12.70 10.00 41 85064 9819 50510200
Disability 12.58 10.00 3 85102 12772 50507247
Convulsions local 12.57 10.00 3 85102 7 50520012
Migraine 12.57 10.00 187 84918 75093 50444926
Quadriplegia 12.56 10.00 15 85090 1708 50518311
Blood cholesterol increased 12.55 10.00 49 85056 55166 50464853
Pancreatitis chronic 12.50 10.00 17 85088 2203 50517816
Hepatitis 12.50 10.00 21 85084 31432 50488587
Catheter site extravasation 12.46 10.00 7 85098 269 50519750
Retinal detachment 12.44 10.00 27 85078 5102 50514917
Eructation 12.43 10.00 33 85072 7088 50512931
Incontinence 12.40 10.00 41 85064 9944 50510075
Bacterial sepsis 12.39 10.00 22 85083 3590 50516429
Incorrect product formulation administered 12.33 10.00 5 85100 91 50519928
Sleep disorder 12.28 10.00 52 85053 57231 50462788
Joint stiffness 12.27 10.00 20 85085 30288 50489731
Infusion site pruritus 12.26 10.00 23 85082 3914 50516105
Feeling hot 12.25 10.00 110 84995 39092 50480927
Drug reaction with eosinophilia and systemic symptoms 12.23 10.00 18 85087 28406 50491613
Gastrointestinal disorder 12.13 10.00 101 85004 94355 50425664
Lung transplant 12.09 10.00 19 85086 2806 50517213
Pseudohyperphosphataemia 12.03 10.00 3 85102 9 50520010
Plasma cell myeloma 11.99 10.00 92 85013 31230 50488789
Injection site pain 11.98 10.00 124 84981 110900 50409119
Sciatica 11.93 10.00 11 85094 21371 50498648
Skin sensitisation 11.82 10.00 10 85095 753 50519266
Foot deformity 11.81 10.00 9 85096 19201 50500818
Lethargy 11.72 10.00 131 84974 49301 50470718
Normal newborn 11.67 10.00 31 85074 6660 50513359
Forced expiratory volume decreased 11.66 10.00 24 85081 4370 50515649
Failure to thrive 11.64 10.00 30 85075 6328 50513691
Vascular parkinsonism 11.63 10.00 5 85100 106 50519913
Cognitive disorder 11.46 10.00 37 85068 44086 50475933
Infusion site irritation 11.38 10.00 9 85096 616 50519403
Blood glucose false positive 11.36 10.00 3 85102 12 50520007
Amylase abnormal 11.36 10.00 3 85102 12 50520007
Respiratory distress 11.36 10.00 89 85016 30400 50489619
Granulocyte count decreased 11.34 10.00 10 85095 796 50519223
Hepatic cyst 11.29 10.00 24 85081 4469 50515550
Multiple sclerosis relapse 11.18 10.00 36 85069 42928 50477091
Metabolic alkalosis 11.18 10.00 18 85087 2713 50517306
Aneurysm ruptured 11.16 10.00 8 85097 472 50519547
Gait inability 11.12 10.00 29 85076 36998 50483021
Infusion site phlebitis 11.09 10.00 4 85101 52 50519967
Thrombocytopenia 11.03 10.00 287 84818 127386 50392633
Blood chloride increased 11.02 10.00 17 85088 2471 50517548
Hepatotoxicity 10.99 10.00 18 85087 27208 50492811
Pulmonary fibrosis 10.98 10.00 15 85090 24422 50495597
Disease complication 10.93 10.00 18 85087 2764 50517255
Intentional product misuse 10.92 10.00 41 85064 46693 50473326
Product substitution issue 10.88 10.00 5 85100 14052 50505967
Hyperglycaemia 10.79 10.00 101 85004 36304 50483715
Inflammatory marker increased 10.75 10.00 27 85078 5607 50514412
Hypoaesthesia oral 10.70 10.00 41 85064 10687 50509332
Bacillus bacteraemia 10.69 10.00 4 85101 58 50519961
Urine analysis abnormal 10.66 10.00 23 85082 4327 50515692
Muscle spasticity 10.63 10.00 8 85097 17176 50502843
Infusion site discomfort 10.61 10.00 10 85095 868 50519151
Aspiration 10.59 10.00 37 85068 9227 50510792
Wrong product administered 10.56 10.00 26 85079 5334 50514685
Breath sounds absent 10.55 10.00 6 85099 236 50519783
Blood potassium increased 10.55 10.00 55 85050 16343 50503676
Pleural effusion 10.51 10.00 194 84911 81260 50438759
Overdose 10.51 10.00 112 84993 99615 50420404
Aortic arteriosclerosis 10.49 10.00 26 85079 5356 50514663
Neuropathy peripheral 10.47 10.00 108 84997 96649 50423370
Multimorbidity 10.46 10.00 8 85097 521 50519498
Noninfectious peritonitis 10.45 10.00 5 85100 137 50519882
Procedural hypotension 10.44 10.00 11 85094 1091 50518928
Hypertrophic cardiomyopathy 10.29 10.00 12 85093 1333 50518686
Sensitisation 10.29 10.00 13 85092 1569 50518450
Renal tubular necrosis 10.26 10.00 39 85066 10129 50509890
Ventricular fibrillation 10.24 10.00 40 85065 10519 50509500
Neutrophil percentage abnormal 10.22 10.00 3 85102 19 50520000
Pulse absent 10.21 10.00 24 85081 4782 50515237
Fracture 10.20 10.00 8 85097 16825 50503194
Injury 10.13 10.00 45 85060 48880 50471139
Urinary tract infection staphylococcal 10.13 10.00 6 85099 255 50519764
Intracranial hypotension 10.07 10.00 6 85099 258 50519761
Blood pressure fluctuation 10.05 10.00 29 85076 35794 50484225
Alanine aminotransferase decreased 10.05 10.00 8 85097 553 50519466
Steatorrhoea 10.01 10.00 7 85098 397 50519622

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Infective pulmonary exacerbation of cystic fibrosis 675.97 10.18 308 62312 5928 29505979
Hyperchloraemia 420.17 10.18 110 62510 313 29511594
Myelosuppression 377.71 10.18 265 62355 11962 29499945
Peritonitis bacterial 369.25 10.18 199 62421 5557 29506350
Peritoneal dialysis complication 248.94 10.18 102 62518 1495 29510412
Cystic fibrosis 194.78 10.18 84 62536 1408 29510499
Peritonitis 185.51 10.18 191 62429 14633 29497274
Fungal peritonitis 179.22 10.18 64 62556 628 29511279
Drug ineffective 167.40 10.18 323 62297 362847 29149060
Toxic anterior segment syndrome 147.40 10.18 62 62558 974 29510933
Completed suicide 146.13 10.18 12 62608 90234 29421673
Hereditary angioedema 130.29 10.18 52 62568 709 29511198
Toxicity to various agents 121.90 10.18 113 62507 173548 29338359
Chills 114.84 10.18 372 62248 70928 29440979
Pyrexia 114.34 10.18 1016 61604 286606 29225301
Drug abuse 111.00 10.18 18 62602 79865 29432042
Bone marrow failure 109.18 10.18 203 62417 27246 29484661
Drug interaction 106.79 10.18 158 62462 197227 29314680
Sputum increased 87 10.18 53 62567 1874 29510033
Cytokine release syndrome 80.52 10.18 118 62502 13001 29498906
Incorrect drug administration rate 79.17 10.18 42 62578 1134 29510773
Temperature intolerance 78.03 10.18 58 62562 2863 29509044
Infusion related reaction 77.05 10.18 236 62384 43650 29468257
Pneumonia 75.15 10.18 1019 61601 319153 29192754
Air embolism 73.84 10.18 22 62598 113 29511794
Sinusitis 73.15 10.18 198 62422 34152 29477755
Death 72.78 10.18 1070 61550 341014 29170893
Device interaction 71.63 10.18 31 62589 524 29511383
Chest discomfort 70.47 10.18 236 62384 45747 29466160
Ultrafiltration failure 66.01 10.18 21 62599 139 29511768
Osmotic demyelination syndrome 65.78 10.18 31 62589 645 29511262
Sepsis 62.70 10.18 516 62104 142166 29369741
Infusion site extravasation 61.81 10.18 52 62568 3075 29508832
Administration site extravasation 61.41 10.18 27 62593 475 29511432
Arthralgia 58.22 10.18 131 62489 139486 29372421
Flushing 57.65 10.18 163 62457 28829 29483078
Hyperpyrexia 55.38 10.18 43 62577 2267 29509640
Hypernatraemia 55.14 10.18 73 62547 7313 29504594
Encapsulating peritoneal sclerosis 54.56 10.18 26 62594 555 29511352
Tachypnoea 52.99 10.18 106 62514 15009 29496898
Pulmonary function test decreased 52.71 10.18 54 62566 4109 29507798
Product preparation error 48.93 10.18 35 62585 1627 29510280
Extravasation 48.74 10.18 35 62585 1637 29510270
Peritoneal cloudy effluent 48.57 10.18 16 62604 120 29511787
Drug intolerance 46.65 10.18 22 62598 48357 29463550
Hypervolaemia 46.60 10.18 110 62510 17435 29494472
Cardiac arrest 45.63 10.18 324 62296 85267 29426640
Noninfectious peritonitis 45.48 10.18 15 62605 113 29511794
White blood cell count decreased 44.70 10.18 316 62304 83046 29428861
Cystic fibrosis respiratory infection suppression 44.62 10.18 17 62603 203 29511704
Increased bronchial secretion 43.59 10.18 32 62588 1549 29510358
Product contamination 41.37 10.18 22 62598 597 29511310
Infusion site pain 40.82 10.18 40 62580 2885 29509022
Joint swelling 40.10 10.18 28 62592 49602 29462305
Rheumatoid arthritis 38.92 10.18 10 62610 32142 29479765
Depression 38.72 10.18 76 62544 85071 29426836
Suicide attempt 38.71 10.18 12 62608 34098 29477809
Intentional overdose 37.95 10.18 17 62603 38511 29473396
Disease complication 37.80 10.18 35 62585 2351 29509556
Overdose 37.38 10.18 70 62550 79749 29432158
Psoriasis 37.19 10.18 11 62609 32216 29479691
Eosinophil count 37.10 10.18 13 62607 120 29511787
Spinal muscular atrophy 36.94 10.18 16 62604 271 29511636
Hospitalisation 36.49 10.18 193 62427 45795 29466112
Suspected transmission of an infectious agent via product 35.70 10.18 20 62600 603 29511304
Upper respiratory tract infection 35.54 10.18 133 62487 27216 29484691
Vocal cord dysfunction 34.60 10.18 13 62607 149 29511758
Burkholderia test positive 34.00 10.18 23 62597 976 29510931
Neutrophil count decreased 33.99 10.18 182 62438 43385 29468522
Febrile neutropenia 33.85 10.18 375 62245 111865 29400042
Drug reaction with eosinophilia and systemic symptoms 33.33 10.18 9 62611 27983 29483924
Device infusion issue 33.32 10.18 19 62601 593 29511314
Pantoea agglomerans infection 33.08 10.18 9 62611 31 29511876
Intentional product misuse 33.05 10.18 16 62604 34645 29477262
Hypoxia 33.02 10.18 192 62428 47187 29464720
Cough 32.31 10.18 410 62210 126317 29385590
Hypokalaemia 32.15 10.18 199 62421 50004 29461903
Pneumococcal sepsis 32.04 10.18 21 62599 845 29511062
Infusion site oedema 31.90 10.18 12 62608 138 29511769
Product contamination microbial 30.69 10.18 18 62602 593 29511314
Therapeutic product effect incomplete 30.67 10.18 23 62597 39282 29472625
Therapeutic product effect decreased 30.60 10.18 12 62608 29439 29482468
Oxygen saturation decreased 30.60 10.18 181 62439 44756 29467151
Gangrene 30.43 10.18 41 62579 4177 29507730
Cyanosis 30.31 10.18 71 62549 11196 29500711
Unresponsive to stimuli 30.04 10.18 119 62501 25007 29486900
Hepatic function abnormal 29.27 10.18 162 62458 39097 29472810
Device related infection 29.23 10.18 86 62534 15550 29496357
Anaphylactic shock 28.50 10.18 77 62543 13259 29498648
Bloody peritoneal effluent 28.38 10.18 10 62610 94 29511813
Weight decreased 28.35 10.18 195 62425 150710 29361197
Suspected product contamination 28.23 10.18 9 62611 60 29511847
Musculoskeletal stiffness 27.87 10.18 23 62597 37435 29474472
Drug resistance 27.45 10.18 6 62614 21534 29490373
Gait disturbance 27.25 10.18 73 62547 73276 29438631
Catheter site infection 26.90 10.18 27 62593 2005 29509902
Peritoneal effluent abnormal 26.87 10.18 8 62612 41 29511866
Toxic epidermal necrolysis 26.76 10.18 92 62528 18061 29493846
Respiratory failure 26.35 10.18 318 62302 96813 29415094
Arthritis 26.32 10.18 10 62610 25009 29486898
Myalgia 25.77 10.18 76 62544 73943 29437964
Respiratory tract infection bacterial 25.49 10.18 16 62604 597 29511310
Immune effector cell-associated neurotoxicity syndrome 25.40 10.18 23 62597 1501 29510406
Complication associated with device 25.30 10.18 42 62578 5149 29506758
Rapid correction of hyponatraemia 25.14 10.18 9 62611 89 29511818
Erectile dysfunction 25.12 10.18 4 62616 18005 29493902
Treatment failure 24.72 10.18 25 62595 36914 29474993
Drug dependence 24.50 10.18 7 62613 20974 29490933
Cataract operation complication 24.43 10.18 10 62610 146 29511761
Gadolinium deposition disease 24.39 10.18 6 62614 12 29511895
Poor quality product administered 24.21 10.18 23 62597 1596 29510311
Pain in extremity 23.66 10.18 137 62483 110296 29401611
Hypotension 23.61 10.18 558 62062 193796 29318111
Dyspnoea 23.11 10.18 877 61743 325855 29186052
Product preparation issue 22.95 10.18 11 62609 238 29511669
Suicidal ideation 22.66 10.18 24 62596 34692 29477215
Endotracheal intubation 22.46 10.18 28 62592 2641 29509266
Eye infection 22.30 10.18 29 62591 2854 29509053
Suffocation feeling 22.17 10.18 14 62606 528 29511379
Tumour lysis syndrome 21.91 10.18 72 62548 13812 29498095
Fungal sepsis 21.47 10.18 16 62604 793 29511114
Coronary artery disease 21.35 10.18 38 62582 44152 29467755
Product deposit 21.18 10.18 11 62609 284 29511623
Vomiting 20.98 10.18 593 62027 211667 29300240
Hyponatraemia 20.38 10.18 226 62394 67407 29444500
Respiratory tract infection 20.24 10.18 76 62544 15575 29496332
Fluid imbalance 20.23 10.18 10 62610 232 29511675
Infective exacerbation of bronchiectasis 20.01 10.18 12 62608 412 29511495
Angioedema 19.80 10.18 23 62597 31892 29480015
Leukoplakia oral 19.75 10.18 7 62613 67 29511840
Disease progression 19.54 10.18 98 62522 81818 29430089
Endophthalmitis 19.51 10.18 27 62593 2821 29509086
Acute respiratory failure 19.04 10.18 108 62512 26294 29485613
Acidosis hyperchloraemic 18.82 10.18 11 62609 360 29511547
Staphylococcal infection 18.77 10.18 116 62504 29124 29482783
Suspected product quality issue 18.50 10.18 8 62612 135 29511772
Bacteraemia 18.46 10.18 76 62544 16247 29495660
Cystic fibrosis related diabetes 18.44 10.18 8 62612 136 29511771
COVID-19 pneumonia 18.40 10.18 53 62567 9469 29502438
COVID-19 18.39 10.18 135 62485 35879 29476028
Blood glucose false positive 18.21 10.18 6 62614 45 29511862
Contraindicated product administered 18.08 10.18 8 62612 18258 29493649
Granulocyte count decreased 18.05 10.18 13 62607 611 29511296
Transurethral resection syndrome 17.88 10.18 4 62616 4 29511903
Resuscitation 17.71 10.18 17 62603 1195 29510712
Dysphoria 17.69 10.18 22 62598 2070 29509837
Body temperature increased 17.68 10.18 69 62551 14396 29497511
Aggression 17.68 10.18 30 62590 35511 29476396
Hepatorenal failure 17.54 10.18 12 62608 519 29511388
Staphylococcus test positive 17.37 10.18 25 62595 2708 29509199
Procedural complication 17.36 10.18 31 62589 4029 29507878
Lower respiratory tract infection bacterial 17.34 10.18 10 62610 319 29511588
Eosinophilia 17.25 10.18 13 62607 22148 29489759
Heart rate increased 17.14 10.18 141 62479 38797 29473110
Cardiovascular disorder 16.56 10.18 49 62571 8886 29503021
Pancreatic failure 16.53 10.18 13 62607 698 29511209
Post procedural complication 16.50 10.18 54 62566 10335 29501572
Foetal exposure during pregnancy 16.47 10.18 29 62591 33838 29478069
Productive cough 16.44 10.18 118 62502 31141 29480766
Infusion site swelling 16.35 10.18 20 62600 1850 29510057
Chemical peritonitis 16.30 10.18 7 62613 116 29511791
Therapeutic response decreased 16.22 10.18 17 62603 24694 29487213
Pneumonia aspiration 16.15 10.18 133 62487 36604 29475303
Vocal cord paralysis 16.13 10.18 14 62606 864 29511043
Failure to thrive 16.05 10.18 44 62576 7640 29504267
Rhinovirus infection 15.65 10.18 26 62594 3190 29508717
Rhegmatogenous retinal detachment 15.24 10.18 5 62615 37 29511870
Urine analysis abnormal 15.17 10.18 19 62601 1801 29510106
Procedural pain 15.16 10.18 30 62590 4214 29507693
Blood pressure fluctuation 15.06 10.18 12 62608 19882 29492025
Sputum retention 15.00 10.18 10 62610 414 29511493
Respiration abnormal 14.87 10.18 23 62597 2657 29509250
Off label use 14.85 10.18 505 62115 300295 29211612
Regurgitation 14.84 10.18 16 62604 1291 29510616
Intentional self-injury 14.84 10.18 4 62616 12457 29499450
Disorganised speech 14.84 10.18 12 62608 671 29511236
Panic reaction 14.76 10.18 16 62604 1299 29510608
Brain herniation 14.60 10.18 27 62593 3606 29508301
Ischaemic cerebral infarction 14.50 10.18 14 62606 991 29510916
Myelodysplastic syndrome 14.42 10.18 10 62610 17784 29494123
Weight increased 14.41 10.18 99 62521 76568 29435339
Metabolic disorder 14.27 10.18 27 62593 3668 29508239
Paraesthesia 14.26 10.18 62 62558 53783 29458124
Peritoneal effluent leukocyte count increased 14.24 10.18 4 62616 16 29511891
Lung transplant 14.11 10.18 18 62602 1738 29510169
Inappropriate antidiuretic hormone secretion 14.06 10.18 53 62567 10879 29501028
Influenza 14.03 10.18 143 62477 41738 29470169
Bronchial obstruction 14.03 10.18 16 62604 1375 29510532
Hyponatraemic encephalopathy 14.01 10.18 5 62615 49 29511858
Complication of device removal 13.92 10.18 5 62615 50 29511857
Motor neurone disease 13.91 10.18 9 62611 354 29511553
Incision site pain 13.89 10.18 18 62602 1765 29510142
Disseminated Bacillus Calmette-Guerin infection 13.83 10.18 7 62613 171 29511736
Injection site extravasation 13.66 10.18 21 62599 2412 29509495
Cystic fibrosis lung 13.66 10.18 5 62615 53 29511854
Hepatocellular injury 13.51 10.18 15 62605 21228 29490679
Tracheostomy malfunction 13.49 10.18 5 62615 55 29511852
Psychotic disorder 13.36 10.18 14 62606 20340 29491567
Anti-thyroid antibody positive 13.25 10.18 5 62615 58 29511849
Neuroleptic malignant syndrome 13.18 10.18 9 62611 16139 29495768
Limb mass 13.18 10.18 11 62609 643 29511264
Cauda equina syndrome 13.18 10.18 9 62611 388 29511519
Atelectasis 13.17 10.18 66 62554 15326 29496581
Infection 13.14 10.18 232 62388 76519 29435388
Stoma closure 13.13 10.18 6 62614 116 29511791
Carbon dioxide increased 13.00 10.18 13 62607 961 29510946
Oropharyngeal discomfort 12.89 10.18 21 62599 2535 29509372
Cardiotoxicity 12.87 10.18 30 62590 4714 29507193
Muscle spasms 12.75 10.18 83 62537 64999 29446908
Intestinal ischaemia 12.69 10.18 37 62583 6655 29505252
Cardiac failure congestive 12.44 10.18 103 62517 76478 29435429
Sinus operation 12.37 10.18 10 62610 559 29511348
Lactobacillus test positive 12.26 10.18 4 62616 29 29511878
Bronchial hyperreactivity 12.24 10.18 15 62605 1391 29510516
Product prescribing error 12.22 10.18 12 62608 17964 29493943
Hepatic cyst ruptured 12.20 10.18 3 62617 6 29511901
Peritoneal fluid analysis abnormal 12.14 10.18 4 62616 30 29511877
Hernia 12.00 10.18 42 62578 8316 29503591
Systemic immune activation 11.92 10.18 4 62616 32 29511875
Arthropathy 11.86 10.18 17 62603 21537 29490370
Lymphadenectomy 11.82 10.18 7 62613 235 29511672
Diabetes mellitus 11.72 10.18 44 62576 39787 29472120
Lung consolidation 11.67 10.18 30 62590 5013 29506894
Disease recurrence 11.55 10.18 10 62610 15904 29496003
Cholestasis 11.49 10.18 20 62600 23442 29488465
Dizziness 11.42 10.18 310 62310 189374 29322533
Blood albumin decreased 11.35 10.18 52 62568 11643 29500264
Respiratory acidosis 11.34 10.18 27 62593 4301 29507606
Peritoneal disorder 11.16 10.18 7 62613 261 29511646
Lower respiratory tract infection 11.14 10.18 95 62525 26407 29485500
Epilepsy 11.13 10.18 72 62548 18360 29493547
Hypoaldosteronism 10.95 10.18 6 62614 173 29511734
Respiratory syncytial virus infection 10.89 10.18 24 62596 3635 29508272
Fasciotomy 10.88 10.18 3 62617 11 29511896
Insomnia 10.81 10.18 128 62492 88633 29423274
Dyspnoea paroxysmal nocturnal 10.75 10.18 14 62606 1380 29510527
Sweat test abnormal 10.68 10.18 3 62617 12 29511895
Product administration error 10.62 10.18 59 62561 14251 29497656
Balance disorder 10.62 10.18 40 62580 36130 29475777
Pruritus 10.57 10.18 323 62297 116526 29395381
Vascular device infection 10.55 10.18 19 62601 2486 29509421
Tumour flare 10.54 10.18 9 62611 543 29511364
Serotonin syndrome 10.46 10.18 13 62607 17499 29494408
Respiratory distress 10.46 10.18 109 62511 31997 29479910
Fatigue 10.36 10.18 557 62063 316264 29195643
Oxygen therapy 10.36 10.18 10 62610 708 29511199
Pneumonia staphylococcal 10.33 10.18 20 62600 2765 29509142
Benign prostatic hyperplasia 10.28 10.18 6 62614 11704 29500203
Obesity 10.28 10.18 4 62616 9859 29502048
Serratia bacteraemia 10.26 10.18 4 62616 51 29511856
Infusion site erythema 10.25 10.18 15 62605 1649 29510258
Serratia infection 10.24 10.18 10 62610 718 29511189

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myelosuppression 1612.70 9.86 817 118834 23013 64356068
Infective pulmonary exacerbation of cystic fibrosis 1272.26 9.86 558 119093 11238 64367843
Bone marrow failure 644.91 9.86 605 119046 47347 64331734
Peritonitis bacterial 458.68 9.86 256 119395 8787 64370294
Agranulocytosis 434.60 9.86 440 119211 37789 64341292
Cystic fibrosis 362.23 9.86 160 119491 3274 64375807
Completed suicide 339.32 9.86 19 119632 224395 64154686
Drug ineffective 308.79 9.86 691 118960 839556 63539525
White blood cell count decreased 308.13 9.86 810 118841 157027 64222054
Chills 282.88 9.86 719 118932 136545 64242536
Hereditary angioedema 274.03 9.86 137 119514 3739 64375342
Toxic anterior segment syndrome 261.65 9.86 115 119536 2324 64376757
Pyrexia 229.23 9.86 1794 117857 556850 63822231
Peritoneal dialysis complication 229.18 9.86 102 119549 2126 64376955
Drug intolerance 211.98 9.86 45 119606 187947 64191134
Joint swelling 206.34 9.86 71 119580 215311 64163770
Chest discomfort 205.54 9.86 575 119076 115531 64263550
Rheumatoid arthritis 198.73 9.86 33 119618 164261 64214820
Toxicity to various agents 189.28 9.86 238 119413 363275 64015806
Neutrophil count decreased 177.60 9.86 422 119229 76774 64302307
Synovitis 168.61 9.86 3 119648 99087 64279994
Fungal peritonitis 166.32 9.86 64 119587 907 64378174
Peritonitis 164.19 9.86 217 119434 24806 64354275
Temperature intolerance 161.28 9.86 129 119522 8126 64370955
Arthralgia 155.05 9.86 372 119279 441888 63937193
Contraindicated product administered 146.32 9.86 15 119636 107814 64271267
Hepatic function abnormal 139.80 9.86 344 119307 63969 64315112
Drug abuse 138.72 9.86 37 119614 132337 64246744
Hyperpyrexia 136.33 9.86 96 119555 4981 64374100
Drug interaction 135.39 9.86 294 119357 361789 64017292
Therapeutic product effect decreased 133.33 9.86 26 119625 115325 64263756
Arthropathy 130.23 9.86 32 119619 120935 64258146
Cytokine release syndrome 129.57 9.86 176 119475 20653 64358428
Leukopenia 129.56 9.86 448 119203 100794 64278287
Device interaction 123.12 9.86 47 119604 651 64378430
Sepsis 121.49 9.86 787 118864 229554 64149527
Flushing 118.57 9.86 368 119283 78280 64300801
Osmotic demyelination syndrome 112.82 9.86 52 119599 1179 64377902
Tachypnoea 110.38 9.86 186 119465 26385 64352696
Sputum increased 110.03 9.86 74 119577 3561 64375520
Hypernatraemia 109.68 9.86 124 119527 12065 64367016
Treatment failure 105.92 9.86 42 119609 116774 64262307
Febrile neutropenia 103.75 9.86 649 119002 187008 64192073
Systemic lupus erythematosus 102.23 9.86 12 119639 77600 64301481
Hyponatraemia 99.51 9.86 540 119111 147799 64231282
Pneumonia 98.70 9.86 1520 118131 558056 63821025
Pantoea agglomerans infection 93.15 9.86 23 119628 57 64379024
Alopecia 91.93 9.86 103 119548 165587 64213494
Vomiting 89.61 9.86 1477 118174 549640 63829441
Hospitalisation 88.65 9.86 324 119327 74883 64304198
Pain 86.32 9.86 637 119014 552874 63826207
Musculoskeletal stiffness 85.79 9.86 62 119589 123144 64255937
Infusion site extravasation 83.75 9.86 82 119569 6755 64372326
Gadolinium deposition disease 83.41 9.86 21 119630 58 64379023
Administration site extravasation 82.52 9.86 40 119611 1019 64378062
Unresponsive to stimuli 78.92 9.86 239 119412 50154 64328927
Extravasation 78.20 9.86 57 119594 3123 64375958
Hyponatraemic encephalopathy 78.02 9.86 27 119624 277 64378804
Dyspnoea 76.32 9.86 1806 117845 716868 63662213
Encapsulating peritoneal sclerosis 76.08 9.86 35 119616 790 64378291
Hypokalaemia 75.90 9.86 435 119216 121468 64257613
Suspected transmission of an infectious agent via product 75.51 9.86 36 119615 883 64378198
Anaphylactic shock 74.30 9.86 170 119481 30158 64348923
Incorrect drug administration rate 72.05 9.86 51 119600 2668 64376413
Cardiac arrest 71.94 9.86 511 119140 153553 64225528
Pulmonary function test decreased 70.89 9.86 73 119578 6388 64372693
Product contamination 70.35 9.86 36 119615 1033 64378048
Cystic fibrosis respiratory infection suppression 70.08 9.86 27 119624 384 64378697
Psoriasis 69.70 9.86 23 119628 71680 64307401
Psoriatic arthropathy 67.45 9.86 3 119648 43278 64335803
Endophthalmitis 66.94 9.86 65 119586 5300 64373781
Acidosis hyperchloraemic 65.83 9.86 30 119621 662 64378419
Incorrect route of product administration 65.47 9.86 138 119513 23160 64355921
Infusion site coldness 65.45 9.86 22 119629 205 64378876
Drug hypersensitivity 64.19 9.86 226 119425 237589 64141492
Arthritis 62.60 9.86 39 119612 83775 64295306
Glossodynia 62.45 9.86 21 119630 64675 64314406
Cyanosis 61.99 9.86 131 119520 22024 64357057
Hypoxia 59.14 9.86 321 119330 87828 64291253
Intentional overdose 59.11 9.86 48 119603 89896 64289185
Suspected product quality issue 57.66 9.86 21 119630 253 64378828
Therapeutic product effect incomplete 56.65 9.86 65 119586 103417 64275664
Product preparation error 56.62 9.86 52 119599 3953 64375128
Hypervolaemia 56.62 9.86 178 119473 38107 64340974
Ultrafiltration failure 55.83 9.86 20 119631 229 64378852
Gamma-glutamyltransferase decreased 55.55 9.86 22 119629 338 64378743
Infusion site pain 54.54 9.86 81 119570 10316 64368765
Respiratory failure 54.20 9.86 496 119155 160687 64218394
Peritoneal cloudy effluent 54.13 9.86 19 119632 204 64378877
Weight increased 52.20 9.86 211 119440 213137 64165944
Suicide attempt 50.38 9.86 35 119616 70972 64308109
Mobility decreased 50.22 9.86 51 119600 85789 64293292
Air embolism 49.35 9.86 21 119630 391 64378690
Infusion site induration 48.94 9.86 26 119625 807 64378274
Depression 48.90 9.86 175 119476 183116 64195965
Blood pressure decreased 48.75 9.86 300 119351 85899 64293182
Disease complication 48.36 9.86 49 119602 4206 64374875
Pericarditis 48.21 9.86 28 119623 62488 64316593
Suspected product contamination 47.57 9.86 14 119637 80 64379001
Infusion site swelling 46.47 9.86 54 119597 5411 64373670
Hepatorenal failure 45.73 9.86 28 119623 1144 64377937
Swelling 44.74 9.86 150 119501 160068 64219013
Wound 44.10 9.86 46 119605 76431 64302650
Oxygen saturation decreased 44.05 9.86 345 119306 106831 64272250
Device related infection 43.10 9.86 140 119511 30486 64348595
Cataract operation complication 43.00 9.86 17 119634 260 64378821
Bacteraemia 42.47 9.86 128 119523 26783 64352298
Pain in extremity 42.37 9.86 359 119292 302726 64076355
Overdose 42.12 9.86 153 119498 159413 64219668
Product contamination microbial 42.07 9.86 24 119627 859 64378222
Spinal muscular atrophy 42.02 9.86 17 119634 277 64378804
Helicobacter infection 41.56 9.86 10 119641 38352 64340729
Infusion site haemorrhage 40.65 9.86 34 119617 2281 64376800
Acute respiratory failure 40.61 9.86 192 119459 49742 64329339
Sopor 40.55 9.86 4 119647 29657 64349424
Peripheral swelling 40.51 9.86 225 119426 208928 64170153
Eosinophil count 40.31 9.86 13 119638 105 64378976
Product preparation issue 40.30 9.86 22 119629 722 64378359
Poor quality product administered 40.20 9.86 39 119612 3176 64375905
Loss of personal independence in daily activities 40.20 9.86 45 119606 72409 64306672
Drug reaction with eosinophilia and systemic symptoms 39.43 9.86 26 119625 54191 64324890
Therapeutic response decreased 39.36 9.86 24 119627 52164 64326917
Granulocytopenia 39.32 9.86 70 119581 10370 64368711
Urticaria 39.21 9.86 432 119219 146885 64232196
Wound infection pseudomonas 38.88 9.86 28 119623 1505 64377576
Fatigue 38.67 9.86 1076 118575 747654 63631427
Condition aggravated 38.12 9.86 475 119176 371951 64007130
Gait disturbance 37.99 9.86 177 119474 171978 64207103
Lymphatic fistula 37.19 9.86 21 119630 737 64378344
Femoral hernia incarcerated 37.11 9.86 21 119630 740 64378341
Disorganised speech 37.04 9.86 28 119623 1622 64377459
Dysphoria 36.71 9.86 43 119608 4345 64374736
Infusion site erythema 36.70 9.86 54 119597 6819 64372262
Pallor 35.18 9.86 154 119497 38627 64340454
Cytopenia 34.92 9.86 84 119567 15387 64363694
Sleep disorder due to general medical condition, insomnia type 34.74 9.86 4 119647 26266 64352815
Haemodialysis complication 34.73 9.86 15 119636 290 64378791
Intentional self-injury 34.72 9.86 6 119645 29038 64350043
Nausea 34.71 9.86 1785 117866 784015 63595066
Platelet count decreased 34.71 9.86 469 119182 167242 64211839
Noninfectious peritonitis 34.22 9.86 14 119637 235 64378846
Intentional product misuse 33.83 9.86 51 119600 72244 64306837
Hypotension 33.65 9.86 935 118716 380039 63999042
Epilepsy 32.61 9.86 136 119515 33395 64345686
C-reactive protein abnormal 32.61 9.86 7 119644 29040 64350041
Infusion related reaction 32.44 9.86 456 119195 164011 64215070
Anaphylactic reaction 32.16 9.86 228 119423 68436 64310645
Infective exacerbation of bronchiectasis 32.11 9.86 19 119632 729 64378352
Blood glucose false positive 31.92 9.86 9 119642 43 64379038
Abdominal discomfort 31.67 9.86 203 119448 182119 64196962
Pancreatic steatosis 31.66 9.86 21 119630 987 64378094
Tumour lysis syndrome 31.18 9.86 93 119558 19347 64359734
Weight decreased 30.91 9.86 360 119291 285379 64093702
Fall 30.83 9.86 566 119085 416260 63962821
Pulmonary oedema 30.55 9.86 250 119401 78424 64300657
Osteoarthritis 30.30 9.86 44 119607 63292 64315789
Balance disorder 29.77 9.86 70 119581 83856 64295225
Osteoporosis 29.50 9.86 21 119630 42059 64337022
Post-traumatic neck syndrome 29.46 9.86 26 119625 1876 64377205
Increased bronchial secretion 29.19 9.86 31 119620 2811 64376270
Suicidal ideation 29.19 9.86 49 119602 66493 64312588
Maternal exposure during delivery 29.07 9.86 19 119632 871 64378210
Pneumococcal sepsis 28.99 9.86 22 119629 1282 64377799
Folliculitis 28.61 9.86 10 119641 30067 64349014
Lymphocyte count decreased 28.50 9.86 150 119501 40549 64338532
Bloody peritoneal effluent 28.45 9.86 11 119640 158 64378923
Burkholderia test positive 28.29 9.86 16 119635 563 64378518
Toxic epidermal necrolysis 28.13 9.86 140 119511 37026 64342055
Anaesthetic complication 28.04 9.86 29 119622 2550 64376531
Immune effector cell-associated neurotoxicity syndrome 27.89 9.86 29 119622 2566 64376515
Granulocyte count decreased 27.21 9.86 21 119630 1255 64377826
Inappropriate antidiuretic hormone secretion 27.07 9.86 97 119554 22192 64356889
Vocal cord dysfunction 27.06 9.86 14 119637 411 64378670
Respiratory distress 27.02 9.86 178 119473 52153 64326928
Myalgia 26.84 9.86 178 119473 158439 64220642
Rhinovirus infection 26.77 9.86 44 119607 6112 64372969
Osteonecrosis of jaw 26.48 9.86 21 119630 39804 64339277
Insomnia 26.43 9.86 237 119414 197599 64181482
Diabetes insipidus 26.31 9.86 37 119614 4484 64374597
Quadriplegia 26.00 9.86 30 119621 2983 64376098
Irritable bowel syndrome 25.74 9.86 19 119632 37350 64341731
Pulse abnormal 25.57 9.86 28 119623 2629 64376452
Injection site pain 25.49 9.86 113 119538 111295 64267786
Drug resistance 25.30 9.86 17 119634 35085 64343996
Abdominal distension 25.30 9.86 281 119370 95713 64283368
Product use issue 25.29 9.86 171 119480 151544 64227537
Failure to thrive 25.13 9.86 58 119593 10346 64368735
Cough 25.11 9.86 736 118915 301412 64077669
Product deposit 25.00 9.86 13 119638 386 64378695
Peritoneal effluent abnormal 24.90 9.86 7 119644 33 64379048
Blood pressure fluctuation 24.85 9.86 36 119615 51835 64327246
Urine analysis abnormal 24.84 9.86 41 119610 5715 64373366
Infusion site oedema 24.39 9.86 15 119636 618 64378463
Vasodilatation 24.30 9.86 29 119622 2989 64376092
Aggression 24.27 9.86 30 119621 46202 64332879
Dehydration 24.14 9.86 549 119102 216214 64162867
Hepatocellular injury 24.12 9.86 29 119622 45206 64333875
Femur fracture 23.98 9.86 17 119634 34118 64344963
Hepatic enzyme increased 23.95 9.86 142 119509 129801 64249280
Sinus operation 23.95 9.86 22 119629 1673 64377408
Injection site reaction 23.74 9.86 31 119620 46633 64332448
Infusion site thrombosis 23.66 9.86 10 119641 183 64378898
Haemoptysis 23.63 9.86 164 119487 48884 64330197
Herpes zoster 23.58 9.86 72 119579 79115 64299966
Staphylococcal infection 23.57 9.86 168 119483 50510 64328571
Device infusion issue 23.26 9.86 22 119629 1736 64377345
Cystic fibrosis lung 23.17 9.86 9 119642 131 64378950
Respiratory tract infection bacterial 23.12 9.86 16 119635 807 64378274
Tachycardia 23.10 9.86 398 119253 149181 64229900
Stomatitis 22.82 9.86 115 119536 109490 64269591
Peripheral coldness 22.75 9.86 66 119585 13518 64365563
Septic shock 22.69 9.86 297 119354 105140 64273941
Catheter site infection 22.51 9.86 39 119612 5654 64373427
Gangrene 22.42 9.86 45 119606 7293 64371788
Fungal sepsis 22.42 9.86 21 119630 1637 64377444
Knee arthroplasty 22.42 9.86 11 119640 26988 64352093
Arterial haemorrhage 22.32 9.86 24 119627 2207 64376874
Seroma 22.16 9.86 23 119628 2031 64377050
Eosinophilia 21.84 9.86 23 119628 38053 64341028
Mental status changes postoperative 21.68 9.86 9 119642 157 64378924
Vein disorder 21.66 9.86 32 119619 4055 64375026
Regurgitation 21.66 9.86 23 119628 2086 64376995
Death 21.32 9.86 1097 118554 481608 63897473
Poisoning 21.29 9.86 7 119644 21872 64357209
Blood creatinine decreased 21.26 9.86 43 119608 7007 64372074
Fluid imbalance 21.23 9.86 12 119639 422 64378659
Discomfort 21.03 9.86 78 119573 80800 64298281
Pruritus 21.01 9.86 742 118909 311658 64067423
Cystic fibrosis related diabetes 20.93 9.86 9 119642 172 64378909
Anaphylactoid reaction 20.79 9.86 34 119617 4704 64374377
Memory impairment 20.77 9.86 85 119566 85597 64293484
Disturbance in attention 20.18 9.86 28 119623 41046 64338035
Chemical peritonitis 19.96 9.86 10 119641 274 64378807
Endotracheal intubation 19.94 9.86 30 119621 3865 64375216
Hypoalbuminaemia 19.85 9.86 75 119576 17599 64361482
Ill-defined disorder 19.73 9.86 32 119619 44020 64335061
Corneal oedema 19.67 9.86 23 119628 2320 64376761
Anterior chamber inflammation 19.63 9.86 12 119639 489 64378592
Rapid correction of hyponatraemia 19.57 9.86 8 119643 134 64378947
Suffocation feeling 19.51 9.86 19 119632 1555 64377526
Product administration error 19.43 9.86 102 119549 27541 64351540
Haemodilution 19.36 9.86 8 119643 138 64378943
COVID-19 pneumonia 19.34 9.86 71 119580 16433 64362648
Distal intestinal obstruction syndrome 19.34 9.86 13 119638 625 64378456
Nasopharyngitis 19.30 9.86 252 119399 195821 64183260
Panic reaction 19.18 9.86 30 119621 3997 64375084
Excessive eye blinking 19.07 9.86 17 119634 1243 64377838
Type 2 diabetes mellitus 19.01 9.86 21 119630 33999 64345082
Eyelid oedema 18.99 9.86 58 119593 12221 64366860
Seizure 18.98 9.86 424 119227 166468 64212613
Cauda equina syndrome 18.95 9.86 16 119635 1087 64377994
Red blood cell sedimentation rate increased 18.91 9.86 18 119633 31217 64347864
Therapy non-responder 18.86 9.86 61 119590 65838 64313243
Hip arthroplasty 18.82 9.86 8 119643 21343 64357738
Sinus tachycardia 18.80 9.86 113 119538 32075 64347006
Lung transplant 18.73 9.86 30 119621 4078 64375003
Cognitive disorder 18.70 9.86 47 119604 55040 64324041
Pulse absent 18.53 9.86 47 119604 8899 64370182
Tachyarrhythmia 18.47 9.86 37 119614 5989 64373092
Procedural complication 18.10 9.86 41 119610 7224 64371857
Blood creatine increased 17.98 9.86 44 119607 8148 64370933
Oropharyngeal discomfort 17.86 9.86 34 119617 5301 64373780
Product dose omission issue 17.84 9.86 254 119397 194493 64184588
Upper respiratory tract infection 17.80 9.86 210 119441 72575 64306506
Pseudomonas infection 17.76 9.86 73 119578 17810 64361271
Staphylococcus test positive 17.71 9.86 35 119616 5610 64373471
Osteonecrosis 17.40 9.86 16 119635 28213 64350868
Stress 17.35 9.86 56 119595 60478 64318603
Mean cell haemoglobin decreased 17.31 9.86 29 119622 4093 64374988
Product container issue 17.02 9.86 14 119637 917 64378164
Electrolyte imbalance 16.97 9.86 92 119559 25151 64353930
Complication associated with device 16.95 9.86 64 119587 15016 64364065
Blood pressure systolic increased 16.94 9.86 42 119609 49411 64329670
Ventricular fibrillation 16.74 9.86 88 119563 23772 64355309
Body temperature increased 16.73 9.86 121 119530 36545 64342536
Confusion postoperative 16.71 9.86 8 119643 198 64378883
Eructation 16.71 9.86 46 119605 9145 64369936
Cardiovascular disorder 16.70 9.86 66 119585 15815 64363266
Infusion site phlebitis 16.67 9.86 7 119644 126 64378955
Pregnancy 16.58 9.86 9 119642 20856 64358225
Systemic inflammatory response syndrome 16.45 9.86 49 119602 10186 64368895
Serratia infection 16.43 9.86 17 119634 1496 64377585
Nephrocalcinosis 16.34 9.86 16 119635 1318 64377763
Anterior chamber disorder 16.08 9.86 7 119644 138 64378943
Diabetes mellitus 16.07 9.86 66 119585 66408 64312673
Neuropathy peripheral 16.03 9.86 140 119511 117385 64261696
Bursitis 16.03 9.86 10 119641 21475 64357606
Coordination abnormal 16.01 9.86 4 119647 14960 64364121
COVID-19 15.95 9.86 188 119463 64952 64314129
Exposure via contaminated device 15.88 9.86 3 119648 0 64379081
Product barcode issue 15.88 9.86 3 119648 0 64379081
Disturbance in social behaviour 15.86 9.86 27 119624 3860 64375221
Hypoaldosteronism 15.78 9.86 9 119642 322 64378759
Acute pulmonary oedema 15.77 9.86 56 119595 12753 64366328
Delirium 15.77 9.86 197 119454 68997 64310084
Dyspnoea paroxysmal nocturnal 15.71 9.86 19 119632 1985 64377096
Mental status changes 15.64 9.86 178 119473 60984 64318097
Disseminated intravascular coagulation 15.48 9.86 108 119543 32240 64346841
Wrong product administered 15.41 9.86 40 119611 7680 64371401
Resuscitation 15.36 9.86 19 119632 2032 64377049
Gait inability 15.29 9.86 35 119616 42333 64336748
Post procedural complication 15.15 9.86 79 119572 21274 64357807
Aortic valve stenosis 15.10 9.86 29 119622 4551 64374530
Pulmonary fibrosis 15.05 9.86 20 119631 29858 64349223
Fracture 15.04 9.86 8 119643 18747 64360334
Lip erosion 15.03 9.86 15 119636 1264 64377817
Rash erythematous 15.00 9.86 147 119504 48486 64330595
Heparin-induced thrombocytopenia 14.98 9.86 42 119609 8437 64370644
Blood albumin decreased 14.98 9.86 78 119573 20995 64358086
Tracheitis 14.93 9.86 15 119636 1275 64377806
Convulsions local 14.84 9.86 5 119646 47 64379034
Aspartate aminotransferase increased 14.79 9.86 308 119343 119480 64259601
Catheter site extravasation 14.76 9.86 9 119642 365 64378716
Chest pain 14.76 9.86 556 119095 235424 64143657
Heart rate increased 14.67 9.86 261 119390 98414 64280667
Thrombocytopenia 14.65 9.86 530 119121 223271 64155810
Sleep disorder 14.61 9.86 59 119592 59650 64319431
Status asthmaticus 14.53 9.86 13 119638 955 64378126
Alanine aminotransferase decreased 14.52 9.86 15 119636 1317 64377764
Blood bilirubin increased 14.49 9.86 167 119484 57386 64321695
Coma 14.47 9.86 99 119552 87516 64291565
Incision site pain 14.39 9.86 21 119630 2633 64376448
Sciatica 14.35 9.86 10 119641 20254 64358827
Transmission of an infectious agent via product 14.34 9.86 7 119644 181 64378900
Erectile dysfunction 14.26 9.86 3 119648 12624 64366457
Haemolysis 14.23 9.86 49 119602 10990 64368091
Basal cell carcinoma 14.19 9.86 22 119629 30816 64348265
Fibromyalgia 14.16 9.86 28 119623 35703 64343378
Multimorbidity 14.03 9.86 13 119638 999 64378082
Corneal disorder 13.95 9.86 18 119633 2009 64377072
Respiration abnormal 13.94 9.86 34 119617 6281 64372800
Disseminated Bacillus Calmette-Guerin infection 13.87 9.86 7 119644 195 64378886
Infusion site ischaemia 13.80 9.86 3 119648 3 64379078
Ileus 13.65 9.86 81 119570 22885 64356196
Hypophysitis 13.58 9.86 24 119627 3535 64375546
Abortion spontaneous 13.53 9.86 16 119635 25127 64353954
Motor neurone disease 13.44 9.86 9 119642 430 64378651
Pleural effusion 13.29 9.86 318 119333 126241 64252840
COVID-19 treatment 13.29 9.86 9 119642 438 64378643
Stoma closure 13.22 9.86 6 119645 131 64378950
Neutrophil count increased 13.22 9.86 86 119565 25088 64353993
Hypercholesterolaemia 13.17 9.86 6 119645 15367 64363714
Blood pressure diastolic abnormal 13.12 9.86 3 119648 11914 64367167
Lactic acidosis 13.03 9.86 64 119587 61346 64317735
Poor feeding infant 12.98 9.86 6 119645 137 64378944
Sputum retention 12.92 9.86 12 119639 925 64378156
Myocardial reperfusion injury 12.90 9.86 4 119647 28 64379053
Hepatic cirrhosis 12.84 9.86 18 119633 26280 64352801
Extradural haematoma 12.84 9.86 20 119631 2656 64376425
Joint stiffness 12.78 9.86 23 119628 30381 64348700
Pneumonia aspiration 12.76 9.86 167 119484 59104 64319977
Angina pectoris 12.71 9.86 42 119609 45039 64334042
Steatorrhoea 12.69 9.86 11 119640 775 64378306
Lactobacillus test positive 12.66 9.86 4 119647 30 64379051
Carbon dioxide increased 12.66 9.86 17 119634 1972 64377109
Wrong product stored 12.59 9.86 3 119648 6 64379075
Hepatic cyst ruptured 12.59 9.86 3 119648 6 64379075
Therapeutic response unexpected 12.57 9.86 8 119643 16993 64362088
Incontinence 12.54 9.86 50 119601 12031 64367050
Multiple sclerosis relapse 12.53 9.86 37 119614 41098 64337983
Cholestasis 12.52 9.86 42 119609 44830 64334251
Feeling cold 12.50 9.86 81 119570 23597 64355484
Infusion site mass 12.45 9.86 12 119639 969 64378112
Drug dependence 12.45 9.86 27 119624 33285 64345796
Product substitution issue 12.41 9.86 9 119642 17852 64361229
Leukostasis syndrome 12.38 9.86 5 119646 81 64379000
Peritoneal disorder 12.37 9.86 10 119641 639 64378442
Wound dehiscence 12.31 9.86 31 119620 5843 64373238
Leukoplakia oral 12.28 9.86 7 119644 250 64378831
Vertigo 12.23 9.86 62 119589 58949 64320132
Normal newborn 12.15 9.86 30 119621 5587 64373494
Forced expiratory volume decreased 12.12 9.86 34 119617 6833 64372248
Moaning 12.10 9.86 12 119639 1004 64378077
Acidosis 12.06 9.86 65 119586 17730 64361351
Lower respiratory tract infection bacterial 12.04 9.86 10 119641 664 64378417
Catheter site pain 12.04 9.86 26 119625 4436 64374645
Incorrect product formulation administered 12.01 9.86 5 119646 88 64378993
Ulcer 11.98 9.86 15 119636 22975 64356106
Blood urea increased 11.97 9.86 130 119521 44023 64335058
Poisoning deliberate 11.93 9.86 5 119646 13453 64365628
Musculoskeletal pain 11.92 9.86 95 119556 81199 64297882
Foot deformity 11.88 9.86 8 119643 16496 64362585
Atelectasis 11.88 9.86 89 119562 27177 64351904
Cardiovascular insufficiency 11.74 9.86 19 119632 2605 64376476
Cystic fibrosis hepatic disease 11.74 9.86 4 119647 39 64379042
Postoperative wound infection 11.72 9.86 44 119607 10292 64368789
Malnutrition 11.72 9.86 68 119583 19057 64360024
Adverse drug reaction 11.72 9.86 44 119607 45420 64333661
Depressed mood 11.71 9.86 38 119613 40974 64338107
Pancreatic failure 11.71 9.86 14 119637 1446 64377635
Injection site vesicles 11.66 9.86 19 119632 2621 64376460
Alanine aminotransferase increased 11.62 9.86 339 119312 138692 64240389
Metabolic disorder 11.57 9.86 36 119615 7661 64371420
Serotonin syndrome 11.49 9.86 36 119615 39246 64339835
Impaired work ability 11.47 9.86 7 119644 15212 64363869
Haemarthrosis 11.38 9.86 28 119623 5201 64373880
Metabolic acidosis 11.38 9.86 190 119461 70768 64308313
Neuroleptic malignant syndrome 11.34 9.86 18 119633 24978 64354103
Vascular parkinsonism 11.29 9.86 5 119646 103 64378978
Pseudohyperphosphataemia 11.27 9.86 3 119648 11 64379070
Ventricular tachycardia 11.27 9.86 105 119546 34160 64344921
Blister 11.24 9.86 96 119555 80871 64298210
Pemphigoid 11.23 9.86 5 119646 12981 64366100
Musculoskeletal disorder 11.22 9.86 10 119641 17896 64361185
Amylase abnormal 11.15 9.86 4 119647 46 64379035
Encephalopathy 11.15 9.86 162 119489 58657 64320424
Dry mouth 11.14 9.86 66 119585 60352 64318729
Poor venous access 11.02 9.86 49 119602 12368 64366713
Bone disorder 10.94 9.86 9 119642 16750 64362331
Respiratory syncytial virus infection 10.93 9.86 34 119617 7234 64371847
Blood chloride increased 10.76 9.86 26 119625 4777 64374304
Brain oedema 10.74 9.86 74 119577 22001 64357080
Hypochloraemia 10.73 9.86 16 119635 2045 64377036
Angioedema 10.64 9.86 69 119582 61752 64317329
Intestinal ischaemia 10.58 9.86 46 119605 11503 64367578
Skin sensitisation 10.56 9.86 10 119641 790 64378291
Autonomic failure syndrome 10.53 9.86 3 119648 15 64379066
Dry eye 10.45 9.86 24 119627 28995 64350086
Peritoneal fluid analysis abnormal 10.44 9.86 4 119647 56 64379025
Joint effusion 10.43 9.86 6 119645 13467 64365614
Amnesia 10.42 9.86 50 119601 48219 64330862
Pneumonia pseudomonal 10.41 9.86 26 119625 4877 64374204
Bronchial obstruction 10.37 9.86 17 119634 2357 64376724
Cardiac failure congestive 10.36 9.86 175 119476 130405 64248676
Atypical mycobacterial lower respiratory tract infection 10.31 9.86 4 119647 58 64379023
Feeling abnormal 10.29 9.86 180 119471 133422 64245659
Second primary malignancy 10.28 9.86 5 119646 12332 64366749
Injection site erythema 10.26 9.86 83 119568 70717 64308364
Dystonia 10.15 9.86 12 119639 18853 64360228
Injection site pruritus 10.15 9.86 36 119615 37790 64341291
Stenotrophomonas test positive 10.13 9.86 7 119644 352 64378729
Vitamin E decreased 10.07 9.86 3 119648 18 64379063
Vitamin B6 increased 10.07 9.86 3 119648 18 64379063
Hyperglycaemia 10.05 9.86 164 119487 60804 64318277
Pneumonia staphylococcal 10.03 9.86 24 119627 4382 64374699
Hepatitis cholestatic 10.02 9.86 5 119646 12150 64366931
Tracheostomy malfunction 10.01 9.86 5 119646 136 64378945
Upper airway obstruction 9.98 9.86 12 119639 1246 64377835
Hepatitis 9.96 9.86 47 119604 45535 64333546
General physical health deterioration 9.91 9.86 296 119355 204129 64174952
Labelled drug-drug interaction medication error 9.90 9.86 16 119635 22046 64357035
Anion gap decreased 9.88 9.86 8 119643 513 64378568
Pollakiuria 9.87 9.86 28 119623 31502 64347579

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 33.00 32.87 15 265 183 84215

Pharmacologic Action:

SourceCodeDescription
ATC A12CA01 ALIMENTARY TRACT AND METABOLISM
MINERAL SUPPLEMENTS
OTHER MINERAL SUPPLEMENTS
Sodium
ATC B05CB01 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
IRRIGATING SOLUTIONS
Salt solutions
ATC B05XA03 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
I.V. SOLUTION ADDITIVES
Electrolyte solutions
ATC S01XA03 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
CHEBI has role CHEBI:79314 flame retardants
CHEBI has role CHEBI:149552 emetics

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

ProductApplicantIngredients
Intragel Zoetis Inc. 2
Re-Sorb, Vytrate Zoetis Inc. 6

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
5MG,N/A;N/A,210GM;N/A,0.74GM;N/A,2.86GM;N/A,5.6GM **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** HALFLYTELY BRAINTREE N021551 July 16, 2010 DISCN FOR SOLUTION, TABLET, DELAYED RELEASE ORAL 7291324 Oct. 22, 2022 GASTROINTESTINAL LAVAGE INDICATED FOR CLEANSING OF THE COLON AS A PREPARATION FOR COLONOSCOPY IN ADULTS
0.21GM/100ML;2.8GM/100ML;9.07GM/100ML NORMOCARB HF 25 DIALYSIS SUPS N021910 July 26, 2006 RX SOLUTION INJECTION 7300674 March 4, 2023 USE AS REPLACEMENT SOLUTION, HEMOFILTRATION SOLUTION OR HEMODIAFILTRATION SOLUTION IN CONTINUOUS RENAL REPLACEMENT THERAPY
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 10792306 March 9, 2032 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 9592252 Aug. 11, 2032 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 10918723 Sept. 10, 2033 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 9326969 Sept. 10, 2033 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
3.68GM/1000ML;3.05GM/1000ML;0.314GM/1000ML ;3.09GM/1000ML;6.34GM/1000ML;0.187GM/1000ML (5000ML) PHOXILLUM BK 4/2.5 IN PLASTIC CONTAINER BAXTER HLTHCARE CORP N207026 Jan. 13, 2015 RX INJECTABLE INJECTION Jan. 13, 2022 AS A REPLACEMENT SOLUTION IN CONTINUOUS RENAL REPLACEMENT THERAPY (CRRT) AND IN CASE OF DRUG POISONING WHEN CRRT IS USED TO REMOVE DIALYZABLE SUBSTANCES
N/A/1000ML;3.05GM/1000ML;0.314GM/1000ML;2.21GM/1000ML;6.95GM/1000ML;0.187GM/1000ML (5000ML) PHOXILLUM B22K 4/0 IN PLASTIC CONTAINER BAXTER HLTHCARE CORP N207026 Jan. 13, 2015 RX INJECTABLE INJECTION Jan. 13, 2022 AS A REPLACEMENT SOLUTION IN CONTINUOUS RENAL REPLACEMENT THERAPY (CRRT) AND IN CASE OF DRUG POISONING WHEN CRRT IS USED TO REMOVE DIALYZABLE SUBSTANCES

Bioactivity Summary:

None

External reference:

IDSource
4017444 VUID
N0000145832 NUI
D02056 KEGG_DRUG
4017444 VANDF
C0037494 UMLSCUI
CHEBI:26710 CHEBI
CHEMBL1200574 ChEMBL_ID
D012965 MESH_DESCRIPTOR_UI
DB09153 DRUGBANK_ID
4155 INN_ID
451W47IQ8X UNII
5234 PUBCHEM_CID
9863 RXNORM
5476 MMSL
6383 MMSL
d00438 MMSL
000759 NDDF
002238 NDDF
387390002 SNOMEDCT_US
70379000 SNOMEDCT_US
786818003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
SODIUM CHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0019-1188 INJECTION 0.90 mg INTRAVASCULAR NDA 17 sections
BSS HUMAN PRESCRIPTION DRUG LABEL 6 0065-0795 SOLUTION 6.40 mg OPHTHALMIC NDA 9 sections
BSS HUMAN PRESCRIPTION DRUG LABEL 6 0065-0795 SOLUTION 6.40 mg OPHTHALMIC NDA 9 sections
BSS HUMAN PRESCRIPTION DRUG LABEL 6 0065-1795 SOLUTION 6.40 mg OPHTHALMIC NDA 9 sections
Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0264-1800 INJECTION, SOLUTION 9 mg INTRAVENOUS NDA 23 sections
Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0264-1800 INJECTION, SOLUTION 9 mg INTRAVENOUS NDA 23 sections
ProcalAmine HUMAN PRESCRIPTION DRUG LABEL 22 0264-1915 INJECTION 0.12 g INTRAVENOUS NDA 24 sections
ProcalAmine HUMAN PRESCRIPTION DRUG LABEL 22 0264-1915 INJECTION 0.12 g INTRAVENOUS NDA 24 sections
HyperlyteCR HUMAN PRESCRIPTION DRUG LABEL 5 0264-1943 INJECTION, SOLUTION, CONCENTRATE 1.17 g INTRAVENOUS UNAPPROVED DRUG OTHER 18 sections
HyperlyteCR HUMAN PRESCRIPTION DRUG LABEL 5 0264-1943 INJECTION, SOLUTION, CONCENTRATE 1.17 g INTRAVENOUS UNAPPROVED DRUG OTHER 18 sections
Balanced Salt HUMAN PRESCRIPTION DRUG LABEL 6 0264-1945 SOLUTION 6.40 mg IRRIGATION ANDA 11 sections
HESPAN HUMAN PRESCRIPTION DRUG LABEL 2 0264-1965 INJECTION, SOLUTION 0.90 g INTRAVENOUS NDA 22 sections
HESPAN HUMAN PRESCRIPTION DRUG LABEL 2 0264-1965 INJECTION, SOLUTION 0.90 g INTRAVENOUS NDA 22 sections
Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0264-2201 IRRIGANT 0.90 g IRRIGATION NDA 23 sections
Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0264-2201 IRRIGANT 0.90 g IRRIGATION NDA 23 sections
Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0264-2201 IRRIGANT 0.90 g IRRIGATION NDA 23 sections
Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0264-2201 IRRIGANT 0.90 g IRRIGATION NDA 23 sections
Ringers HUMAN PRESCRIPTION DRUG LABEL 3 0264-2202 IRRIGANT 0.86 g IRRIGATION NDA 22 sections
Ringers HUMAN PRESCRIPTION DRUG LABEL 3 0264-2202 IRRIGANT 0.86 g IRRIGATION NDA 22 sections
Ringers HUMAN PRESCRIPTION DRUG LABEL 3 0264-2202 IRRIGANT 0.86 g IRRIGATION NDA 22 sections
Ringers HUMAN PRESCRIPTION DRUG LABEL 3 0264-2202 IRRIGANT 0.86 g IRRIGATION NDA 22 sections
Lactated Ringers HUMAN PRESCRIPTION DRUG LABEL 4 0264-2203 IRRIGANT 0.60 g IRRIGATION NDA 18 sections
Lactated Ringers HUMAN PRESCRIPTION DRUG LABEL 4 0264-2203 IRRIGANT 0.60 g IRRIGATION NDA 18 sections
Physiolyte HUMAN PRESCRIPTION DRUG LABEL 5 0264-2205 IRRIGANT 0.53 g IRRIGATION NDA 20 sections
Physiolyte HUMAN PRESCRIPTION DRUG LABEL 5 0264-2205 IRRIGANT 0.53 g IRRIGATION NDA 20 sections
Balanced Salt HUMAN PRESCRIPTION DRUG LABEL 6 0264-2514 SOLUTION 6.40 mg IRRIGATION ANDA 11 sections
Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0264-5802 INJECTION, SOLUTION 0.90 g INTRAVENOUS NDA 20 sections
Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0264-5802 INJECTION, SOLUTION 0.90 g INTRAVENOUS NDA 20 sections
Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0264-5804 INJECTION, SOLUTION 0.45 g INTRAVENOUS NDA 20 sections
Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0264-5804 INJECTION, SOLUTION 0.45 g INTRAVENOUS NDA 20 sections