vitamin A palmitate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4197 | 79-81-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| May 18, 1949 | FDA | HOSPIRA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Pleural thickening | 106.72 | 87.52 | 20 | 681 | 2579 | 50601844 |
| Presbyacusis | 105.41 | 87.52 | 20 | 681 | 2756 | 50601667 |
| Blood magnesium increased | 104.67 | 87.52 | 20 | 681 | 2860 | 50601563 |
| Pleural fibrosis | 101.45 | 87.52 | 20 | 681 | 3364 | 50601059 |
| Deafness neurosensory | 95.76 | 87.52 | 20 | 681 | 4481 | 50599942 |
| Epigastric discomfort | 90.47 | 87.52 | 20 | 681 | 5850 | 50598573 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hypervitaminosis A | 97.25 | 91.37 | 9 | 128 | 6 | 29574384 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hypervitaminosis A | 123.37 | 75.89 | 13 | 746 | 18 | 64497955 |
| Presbyacusis | 84.51 | 75.89 | 16 | 743 | 2559 | 64495414 |
| Pleural thickening | 83.69 | 75.89 | 16 | 743 | 2694 | 64495279 |
| Blood magnesium increased | 80.88 | 75.89 | 16 | 743 | 3215 | 64494758 |
| Pleural fibrosis | 77.28 | 75.89 | 16 | 743 | 4034 | 64493939 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D016588 | Anticarcinogenic Agents |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D000975 | Antioxidants |
| MeSH PA | D020011 | Protective Agents |
| MeSH PA | D018977 | Micronutrients |
| MeSH PA | D014815 | Vitamins |
| CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
| CHEBI has role | CHEBI:76924 | plant metabolites |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
| CHEBI has role | CHEBI:22586 | antioxidants |
| CHEBI has role | CHEBI:76967 | human xenobiotic metabolites |
| CHEBI has role | CHEBI:76971 | Escherichia coli metabolites |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Vitamin deficiency | indication | 85670002 | |
| Prevention of dental caries | indication | 426482000 | |
| Dental fluorosis | contraindication | 30265004 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Retinol-binding protein 4 | Secreted | Kd | 6.74 | CHEMBL | |||||
| Amyloid beta A4 protein | Unclassified | IC50 | 6.75 | CHEMBL | |||||
| Alpha-synuclein | Transporter | IC50 | 6.72 | CHEMBL | |||||
| Beta-lactoglobulin | Unclassified | Kd | 7.44 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4020767 | VUID |
| N0000179230 | NUI |
| D00164 | KEGG_DRUG |
| 4017648 | VANDF |
| 4017669 | VANDF |
| 4020767 | VANDF |
| 4021164 | VANDF |
| C0073115 | UMLSCUI |
| CHEBI:17616 | CHEBI |
| CHEBI:50211 | CHEBI |
| RTL | PDB_CHEM_ID |
| CHEMBL1675 | ChEMBL_ID |
| CHEMBL986 | ChEMBL_ID |
| C014794 | MESH_SUPPLEMENTAL_RECORD_UI |
| 1D1K0N0VVC | UNII |
| 5280531 | PUBCHEM_CID |
| 445354 | PUBCHEM_CID |
| DB00162 | DRUGBANK_ID |
| 11246 | RXNORM |
| 232172 | MMSL |
| 5678 | MMSL |
| 5680 | MMSL |
| 975 | MMSL |
| d00402 | MMSL |
| 001000 | NDDF |
| 001002 | NDDF |
| 422160004 | SNOMEDCT_US |
| 82156005 | SNOMEDCT_US |
| 82622003 | SNOMEDCT_US |
| C0042839 | UMLSCUI |
| 2243 | INN_ID |
| D014801 | MESH_DESCRIPTOR_UI |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Quflora FE Pediatric Drops | HUMAN PRESCRIPTION DRUG LABEL | 14 | 15370-102 | LIQUID | 1500 [iU] | ORAL | UNAPPROVED DRUG OTHER | 11 sections |
| Quflora FE Pediatric Drops | HUMAN PRESCRIPTION DRUG LABEL | 14 | 15370-102 | LIQUID | 1500 [iU] | ORAL | UNAPPROVED DRUG OTHER | 11 sections |
| PEDIATRIC INFUVITE MULTIPLE VITAMINS FOR INFUSION | HUMAN PRESCRIPTION DRUG LABEL | 13 | 54643-5646 | INJECTION, SOLUTION | 2300 [iU] | INTRAVENOUS | NDA | 19 sections |
| Adult Infuvite Multiple Vitamins for Infusion | HUMAN PRESCRIPTION DRUG LABEL | 13 | 54643-5649 | INJECTION, SOLUTION | 3300 [iU] | INTRAVENOUS | NDA | 17 sections |
| Adult Infuvite Multiple Vitamins for Infusion | HUMAN PRESCRIPTION DRUG LABEL | 13 | 54643-5649 | INJECTION, SOLUTION | 3300 [iU] | INTRAVENOUS | NDA | 17 sections |
| Infuvite Adult Multiple Vitamins | HUMAN PRESCRIPTION DRUG LABEL | 13 | 54643-5650 | INJECTION, SOLUTION | 3300 [iU] | INTRAVENOUS | NDA | 20 sections |
| Adult Infuvite Multiple Vitamins | HUMAN PRESCRIPTION DRUG LABEL | 13 | 54643-7862 | INJECTION, SOLUTION | 3300 [iU] | INTRAVENOUS | NDA | 20 sections |
| Adult Infuvite Multiple Vitamins | HUMAN PRESCRIPTION DRUG LABEL | 13 | 54643-7874 | INJECTION, SOLUTION | 3300 [iU] | INTRAVENOUS | NDA | 20 sections |
| Pediatric Infuvite Multiple Vitamins | HUMAN PRESCRIPTION DRUG LABEL | 13 | 54643-7886 | INJECTION, SOLUTION | 2300 [iU] | INTRAVENOUS | NDA | 19 sections |
| Adult Infuvite Multiple Vitamins | HUMAN PRESCRIPTION DRUG LABEL | 13 | 54643-9007 | INJECTION, SOLUTION | 3300 [iU] | INTRAVENOUS | NDA | 20 sections |
| Adult Infuvite Multiple Vitamins | HUMAN PRESCRIPTION DRUG LABEL | 13 | 54643-9015 | INJECTION, SOLUTION | 3300 [iU] | INTRAVENOUS | NDA | 20 sections |
| Pediatric Infuvite Multiple Vitamins | HUMAN PRESCRIPTION DRUG LABEL | 13 | 54643-9023 | INJECTION, SOLUTION | 2300 [iU] | INTRAVENOUS | NDA | 19 sections |
| Multi-Vitamin with Fluoride | HUMAN PRESCRIPTION DRUG LABEL | 10 | 58657-325 | LIQUID | 1500 [iU] | ORAL | unapproved drug other | 10 sections |
| Multi-Vitamin with Fluoride | HUMAN PRESCRIPTION DRUG LABEL | 10 | 58657-326 | LIQUID | 1500 [iU] | ORAL | unapproved drug other | 10 sections |
| Multi-Vitamin Drops with Fluoride and Iron | HUMAN PRESCRIPTION DRUG LABEL | 10 | 58657-327 | LIQUID | 1500 [iU] | ORAL | unapproved drug other | 10 sections |
| AQUASOL A | Human Prescription Drug Label | 1 | 70199-026 | INJECTION, SOLUTION | 15 mg | INTRAMUSCULAR | NDA | 12 sections |
| Derma Anti-Wrinkles | HUMAN OTC DRUG LABEL | 3 | 82160-436 | CREAM | 0.90 mg | TOPICAL | unapproved drug other | 13 sections |