vitamin A palmitate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4197 79-81-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • vitamin A palmitate
  • retinol palmitate
  • retinyl palmitate
  • Molecular weight: 524.87
  • Formula: C36H60O2
  • CLOGP: 12
  • LIPINSKI: 2
  • HAC: 2
  • HDO: 0
  • TPSA: 26.30
  • ALOGS: -6.81
  • ROTB: 21

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 18, 1949 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pleural thickening 106.72 87.52 20 681 2579 50601844
Presbyacusis 105.41 87.52 20 681 2756 50601667
Blood magnesium increased 104.67 87.52 20 681 2860 50601563
Pleural fibrosis 101.45 87.52 20 681 3364 50601059
Deafness neurosensory 95.76 87.52 20 681 4481 50599942
Epigastric discomfort 90.47 87.52 20 681 5850 50598573

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypervitaminosis A 97.25 91.37 9 128 6 29574384

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypervitaminosis A 123.37 75.89 13 746 18 64497955
Presbyacusis 84.51 75.89 16 743 2559 64495414
Pleural thickening 83.69 75.89 16 743 2694 64495279
Blood magnesium increased 80.88 75.89 16 743 3215 64494758
Pleural fibrosis 77.28 75.89 16 743 4034 64493939

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D016588 Anticarcinogenic Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000975 Antioxidants
MeSH PA D020011 Protective Agents
MeSH PA D018977 Micronutrients
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:76967 human xenobiotic metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Vitamin deficiency indication 85670002
Prevention of dental caries indication 426482000
Dental fluorosis contraindication 30265004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Retinol-binding protein 4 Secreted Kd 6.74 CHEMBL
Amyloid beta A4 protein Unclassified IC50 6.75 CHEMBL
Alpha-synuclein Transporter IC50 6.72 CHEMBL
Beta-lactoglobulin Unclassified Kd 7.44 CHEMBL

External reference:

IDSource
4020767 VUID
N0000179230 NUI
D00164 KEGG_DRUG
4017648 VANDF
4017669 VANDF
4020767 VANDF
4021164 VANDF
C0073115 UMLSCUI
CHEBI:17616 CHEBI
CHEBI:50211 CHEBI
RTL PDB_CHEM_ID
CHEMBL1675 ChEMBL_ID
CHEMBL986 ChEMBL_ID
C014794 MESH_SUPPLEMENTAL_RECORD_UI
1D1K0N0VVC UNII
5280531 PUBCHEM_CID
445354 PUBCHEM_CID
DB00162 DRUGBANK_ID
11246 RXNORM
232172 MMSL
5678 MMSL
5680 MMSL
975 MMSL
d00402 MMSL
001000 NDDF
001002 NDDF
422160004 SNOMEDCT_US
82156005 SNOMEDCT_US
82622003 SNOMEDCT_US
C0042839 UMLSCUI
2243 INN_ID
D014801 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Quflora FE Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 14 15370-102 LIQUID 1500 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora FE Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 14 15370-102 LIQUID 1500 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
PEDIATRIC INFUVITE MULTIPLE VITAMINS FOR INFUSION HUMAN PRESCRIPTION DRUG LABEL 13 54643-5646 INJECTION, SOLUTION 2300 [iU] INTRAVENOUS NDA 19 sections
Adult Infuvite Multiple Vitamins for Infusion HUMAN PRESCRIPTION DRUG LABEL 13 54643-5649 INJECTION, SOLUTION 3300 [iU] INTRAVENOUS NDA 17 sections
Adult Infuvite Multiple Vitamins for Infusion HUMAN PRESCRIPTION DRUG LABEL 13 54643-5649 INJECTION, SOLUTION 3300 [iU] INTRAVENOUS NDA 17 sections
Infuvite Adult Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-5650 INJECTION, SOLUTION 3300 [iU] INTRAVENOUS NDA 20 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-7862 INJECTION, SOLUTION 3300 [iU] INTRAVENOUS NDA 20 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-7874 INJECTION, SOLUTION 3300 [iU] INTRAVENOUS NDA 20 sections
Pediatric Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-7886 INJECTION, SOLUTION 2300 [iU] INTRAVENOUS NDA 19 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-9007 INJECTION, SOLUTION 3300 [iU] INTRAVENOUS NDA 20 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-9015 INJECTION, SOLUTION 3300 [iU] INTRAVENOUS NDA 20 sections
Pediatric Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-9023 INJECTION, SOLUTION 2300 [iU] INTRAVENOUS NDA 19 sections
Multi-Vitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 10 58657-325 LIQUID 1500 [iU] ORAL unapproved drug other 10 sections
Multi-Vitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 10 58657-326 LIQUID 1500 [iU] ORAL unapproved drug other 10 sections
Multi-Vitamin Drops with Fluoride and Iron HUMAN PRESCRIPTION DRUG LABEL 10 58657-327 LIQUID 1500 [iU] ORAL unapproved drug other 10 sections
AQUASOL A Human Prescription Drug Label 1 70199-026 INJECTION, SOLUTION 15 mg INTRAMUSCULAR NDA 12 sections
Derma Anti-Wrinkles HUMAN OTC DRUG LABEL 3 82160-436 CREAM 0.90 mg TOPICAL unapproved drug other 13 sections