Stem definition | Drug id | CAS RN |
---|---|---|
platelet aggregation inhibitors | 4184 | 274693-27-5 |
Dose | Unit | Route |
---|---|---|
0.18 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Hosey CM, Chan R, Benet LZ |
Vd (Volume of distribution) | 1.25 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 3.38 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.00 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 6.80 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
July 20, 2011 | FDA | ASTRAZENECA LP |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Vascular stent thrombosis | 620.58 | 19.05 | 116 | 10824 | 755 | 46674367 |
Thrombosis in device | 348.40 | 19.05 | 90 | 10850 | 2889 | 46672233 |
Rhabdomyolysis | 320.00 | 19.05 | 168 | 10772 | 41741 | 46633381 |
Acute myocardial infarction | 290.21 | 19.05 | 144 | 10796 | 31780 | 46643342 |
Myocardial infarction | 266.92 | 19.05 | 204 | 10736 | 97324 | 46577798 |
Dyspnoea | 220.72 | 19.05 | 414 | 10526 | 515134 | 46159988 |
Drug interaction | 167.33 | 19.05 | 221 | 10719 | 202873 | 46472249 |
Gastrointestinal haemorrhage | 158.84 | 19.05 | 137 | 10803 | 77236 | 46597886 |
Haemorrhage | 122.47 | 19.05 | 102 | 10838 | 54767 | 46620355 |
Haemorrhage intracranial | 108.42 | 19.05 | 55 | 10885 | 12669 | 46662453 |
Acute coronary syndrome | 101.47 | 19.05 | 49 | 10891 | 10155 | 46664967 |
Angina pectoris | 98.12 | 19.05 | 67 | 10873 | 26708 | 46648414 |
Vascular stent stenosis | 85.88 | 19.05 | 21 | 10919 | 535 | 46674587 |
Epistaxis | 84.39 | 19.05 | 89 | 10851 | 64216 | 46610906 |
Cerebral haemorrhage | 83.22 | 19.05 | 62 | 10878 | 28309 | 46646813 |
Acute kidney injury | 82.63 | 19.05 | 175 | 10765 | 235680 | 46439442 |
Chest pain | 72.61 | 19.05 | 140 | 10800 | 176184 | 46498938 |
Melaena | 71.15 | 19.05 | 56 | 10884 | 27716 | 46647406 |
Angina unstable | 65.38 | 19.05 | 33 | 10907 | 7515 | 46667607 |
Atrioventricular block complete | 65.05 | 19.05 | 33 | 10907 | 7594 | 46667528 |
Bradycardia | 61.96 | 19.05 | 77 | 10863 | 66221 | 46608901 |
Coronary artery thrombosis | 57.68 | 19.05 | 18 | 10922 | 1147 | 46673975 |
Sinus arrest | 54.51 | 19.05 | 19 | 10921 | 1712 | 46673410 |
Cardiogenic shock | 53 | 19.05 | 38 | 10902 | 16346 | 46658776 |
Haematoma | 52.62 | 19.05 | 50 | 10890 | 31822 | 46643300 |
Coronary artery stenosis | 51.02 | 19.05 | 24 | 10916 | 4689 | 46670433 |
Coronary artery restenosis | 50.02 | 19.05 | 13 | 10927 | 426 | 46674696 |
Cardiac failure | 49.31 | 19.05 | 76 | 10864 | 79872 | 46595250 |
Anaemia | 46.07 | 19.05 | 148 | 10792 | 255631 | 46419491 |
Myopathy | 44.31 | 19.05 | 27 | 10913 | 8854 | 46666268 |
Cardiac arrest | 39.87 | 19.05 | 74 | 10866 | 90325 | 46584797 |
Platelet function test abnormal | 39.71 | 19.05 | 8 | 10932 | 80 | 46675042 |
Intentional product misuse | 39.69 | 19.05 | 52 | 10888 | 47076 | 46628046 |
Coronary artery occlusion | 38.81 | 19.05 | 24 | 10916 | 8078 | 46667044 |
Rheumatoid arthritis | 36.97 | 19.05 | 6 | 10934 | 240209 | 46434913 |
Coronary artery disease | 34.43 | 19.05 | 41 | 10899 | 33711 | 46641411 |
Labelled drug-drug interaction medication error | 33.94 | 19.05 | 23 | 10917 | 9038 | 46666084 |
Haemorrhagic stroke | 33.22 | 19.05 | 19 | 10921 | 5547 | 46669575 |
Upper gastrointestinal haemorrhage | 32.97 | 19.05 | 29 | 10911 | 16709 | 46658413 |
Atrioventricular block | 32.18 | 19.05 | 20 | 10920 | 6791 | 46668331 |
Coronary artery dissection | 31.41 | 19.05 | 10 | 10930 | 680 | 46674442 |
Diabetic macroangiopathy | 30.48 | 19.05 | 7 | 10933 | 135 | 46674987 |
Subarachnoid haemorrhage | 29.65 | 19.05 | 23 | 10917 | 11130 | 46663992 |
Product name confusion | 29.60 | 19.05 | 6 | 10934 | 62 | 46675060 |
Device occlusion | 29.47 | 19.05 | 18 | 10922 | 5927 | 46669195 |
Hepatitis | 29.40 | 19.05 | 37 | 10903 | 32178 | 46642944 |
Alveolar proteinosis | 29.39 | 19.05 | 8 | 10932 | 314 | 46674808 |
Forced vital capacity decreased | 28.73 | 19.05 | 10 | 10930 | 897 | 46674225 |
Subdural haematoma | 28.61 | 19.05 | 24 | 10916 | 12973 | 46662149 |
Arterial restenosis | 28.37 | 19.05 | 5 | 10935 | 22 | 46675100 |
Ventricular asystole | 27.93 | 19.05 | 6 | 10934 | 84 | 46675038 |
Eosinophilia | 27.70 | 19.05 | 28 | 10912 | 19189 | 46655933 |
Faeces discoloured | 27.06 | 19.05 | 26 | 10914 | 16761 | 46658361 |
Acid base balance abnormal | 26.01 | 19.05 | 7 | 10933 | 263 | 46674859 |
Coma acidotic | 25.55 | 19.05 | 6 | 10934 | 128 | 46674994 |
Brain natriuretic peptide increased | 25.43 | 19.05 | 15 | 10925 | 4635 | 46670487 |
Toxicity to various agents | 25.33 | 19.05 | 9 | 10931 | 211757 | 46463365 |
Arthralgia | 25.25 | 19.05 | 29 | 10911 | 364574 | 46310548 |
Pyrexia | 24.97 | 19.05 | 27 | 10913 | 348775 | 46326347 |
Myositis | 24.80 | 19.05 | 18 | 10922 | 7886 | 46667236 |
Rectal haemorrhage | 24.45 | 19.05 | 37 | 10903 | 38218 | 46636904 |
Spinal cord haemorrhage | 23.89 | 19.05 | 6 | 10934 | 171 | 46674951 |
Drug-induced liver injury | 22.93 | 19.05 | 29 | 10911 | 25339 | 46649783 |
Hepatitis cholestatic | 22.77 | 19.05 | 16 | 10924 | 6661 | 46668461 |
Chest discomfort | 22.74 | 19.05 | 59 | 10881 | 90210 | 46584912 |
Infarction | 22.72 | 19.05 | 11 | 10929 | 2290 | 46672832 |
Capillary fragility test | 21.66 | 19.05 | 4 | 10936 | 24 | 46675098 |
Drug ineffective | 21.58 | 19.05 | 84 | 10856 | 677754 | 45997368 |
Iron deficiency anaemia | 21.10 | 19.05 | 23 | 10917 | 17183 | 46657939 |
Fibroma | 21.05 | 19.05 | 8 | 10932 | 921 | 46674201 |
Myocardial ischaemia | 21.03 | 19.05 | 20 | 10920 | 12729 | 46662393 |
Vascular stent occlusion | 20.88 | 19.05 | 4 | 10936 | 30 | 46675092 |
Haemoglobin decreased | 20.81 | 19.05 | 72 | 10868 | 128877 | 46546245 |
Electrocardiogram ST segment elevation | 20.42 | 19.05 | 12 | 10928 | 3683 | 46671439 |
Catheter site haematoma | 19.92 | 19.05 | 5 | 10935 | 142 | 46674980 |
Hepatitis acute | 19.82 | 19.05 | 16 | 10924 | 8198 | 46666924 |
Cell death | 19.80 | 19.05 | 10 | 10930 | 2278 | 46672844 |
Eosinophil cationic protein increased | 19.51 | 19.05 | 4 | 10936 | 44 | 46675078 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Vascular stent thrombosis | 1238.90 | 15.77 | 294 | 20411 | 2049 | 29929724 |
Thrombosis in device | 879.16 | 15.77 | 243 | 20462 | 3283 | 29928490 |
Acute myocardial infarction | 432.21 | 15.77 | 329 | 20376 | 52610 | 29879163 |
Dyspnoea | 400.36 | 15.77 | 773 | 19932 | 332522 | 29599251 |
Myocardial infarction | 300.19 | 15.77 | 400 | 20305 | 125225 | 29806548 |
Gastrointestinal haemorrhage | 182.64 | 15.77 | 255 | 20450 | 83191 | 29848582 |
Chest pain | 178.09 | 15.77 | 303 | 20402 | 117324 | 29814449 |
Angina pectoris | 170.04 | 15.77 | 150 | 20555 | 29368 | 29902405 |
Sinus arrest | 159.85 | 15.77 | 54 | 20651 | 1466 | 29930307 |
Rhabdomyolysis | 156.82 | 15.77 | 206 | 20499 | 63374 | 29868399 |
Acute coronary syndrome | 155.78 | 15.77 | 104 | 20601 | 13469 | 29918304 |
Haemorrhage intracranial | 155.47 | 15.77 | 108 | 20597 | 14924 | 29916849 |
Vascular stent stenosis | 152.91 | 15.77 | 48 | 20657 | 1026 | 29930747 |
Angina unstable | 152.65 | 15.77 | 99 | 20606 | 12211 | 29919562 |
Cerebral haemorrhage | 150.50 | 15.77 | 147 | 20558 | 32740 | 29899033 |
Drug interaction | 139.33 | 15.77 | 375 | 20330 | 199193 | 29732580 |
Sinoatrial block | 130.27 | 15.77 | 35 | 20670 | 420 | 29931353 |
Melaena | 124.72 | 15.77 | 132 | 20573 | 32305 | 29899468 |
Coronary artery occlusion | 105.71 | 15.77 | 76 | 20629 | 11081 | 29920692 |
Haemorrhage | 99.41 | 15.77 | 140 | 20565 | 45939 | 29885834 |
Toxicity to various agents | 92.97 | 15.77 | 8 | 20697 | 177175 | 29754598 |
Intentional product misuse | 87.96 | 15.77 | 114 | 20591 | 34553 | 29897220 |
Pulmonary haemorrhage | 86.74 | 15.77 | 63 | 20642 | 9329 | 29922444 |
Bradycardia | 86.26 | 15.77 | 159 | 20546 | 65367 | 29866406 |
Chest discomfort | 84.79 | 15.77 | 129 | 20576 | 45351 | 29886422 |
Vascular stent occlusion | 81.56 | 15.77 | 19 | 20686 | 120 | 29931653 |
Rectal haemorrhage | 78.08 | 15.77 | 108 | 20597 | 34831 | 29896942 |
Coronary artery restenosis | 75.32 | 15.77 | 29 | 20676 | 1154 | 29930619 |
Coronary artery stenosis | 75.15 | 15.77 | 57 | 20648 | 9013 | 29922760 |
Coronary artery thrombosis | 73.73 | 15.77 | 34 | 20671 | 2130 | 29929643 |
Subdural haematoma | 70.74 | 15.77 | 76 | 20629 | 18896 | 29912877 |
Anaemia | 66.52 | 15.77 | 302 | 20403 | 207690 | 29724083 |
Cardiac ventricular thrombosis | 63.39 | 15.77 | 23 | 20682 | 774 | 29930999 |
Atrioventricular block complete | 63.10 | 15.77 | 50 | 20655 | 8427 | 29923346 |
Epistaxis | 61.61 | 15.77 | 122 | 20583 | 52859 | 29878914 |
Haematuria | 60.49 | 15.77 | 110 | 20595 | 44724 | 29887049 |
Subarachnoid haemorrhage | 60.41 | 15.77 | 52 | 20653 | 9834 | 29921939 |
Cardiogenic shock | 60.16 | 15.77 | 66 | 20639 | 16795 | 29914978 |
Labelled drug-drug interaction medication error | 59.52 | 15.77 | 53 | 20652 | 10485 | 29921288 |
Atrioventricular block | 58.65 | 15.77 | 45 | 20660 | 7237 | 29924536 |
Coronary artery disease | 57.23 | 15.77 | 114 | 20591 | 49598 | 29882175 |
Shock haemorrhagic | 56.48 | 15.77 | 50 | 20655 | 9815 | 29921958 |
Febrile neutropenia | 55.41 | 15.77 | 5 | 20700 | 106688 | 29825085 |
Device occlusion | 54.12 | 15.77 | 40 | 20665 | 6080 | 29925693 |
Platelet aggregation inhibition | 54.03 | 15.77 | 10 | 20695 | 14 | 29931759 |
Haemorrhagic stroke | 53.97 | 15.77 | 40 | 20665 | 6107 | 29925666 |
Brain herniation | 53.65 | 15.77 | 33 | 20672 | 3707 | 29928066 |
Cardiac arrest | 53.34 | 15.77 | 163 | 20542 | 92687 | 29839086 |
Pyrexia | 49.22 | 15.77 | 80 | 20625 | 294409 | 29637364 |
Completed suicide | 45.87 | 15.77 | 7 | 20698 | 99485 | 29832288 |
Haematoma | 44.68 | 15.77 | 68 | 20637 | 23885 | 29907888 |
Gastric haemorrhage | 44.53 | 15.77 | 43 | 20662 | 9424 | 29922349 |
White blood cell count decreased | 43.40 | 15.77 | 4 | 20701 | 83943 | 29847830 |
Pneumonia | 42.86 | 15.77 | 106 | 20599 | 334200 | 29597573 |
Blood loss anaemia | 42.35 | 15.77 | 38 | 20667 | 7589 | 29924184 |
Product dose omission issue | 41.98 | 15.77 | 149 | 20556 | 91482 | 29840291 |
Arterial restenosis | 41.43 | 15.77 | 10 | 20695 | 75 | 29931698 |
Gastric ulcer haemorrhage | 40.96 | 15.77 | 32 | 20673 | 5282 | 29926491 |
Neutropenia | 40.66 | 15.77 | 19 | 20686 | 128521 | 29803252 |
Thrombosis | 40.61 | 15.77 | 90 | 20615 | 42141 | 29889632 |
Ventricular asystole | 39.58 | 15.77 | 11 | 20694 | 151 | 29931622 |
Rash maculo-papular | 38.97 | 15.77 | 66 | 20639 | 25352 | 29906421 |
Sinus bradycardia | 38.66 | 15.77 | 44 | 20661 | 11651 | 29920122 |
Haematemesis | 36.22 | 15.77 | 65 | 20640 | 26138 | 29905635 |
Malignant neoplasm progression | 35.92 | 15.77 | 4 | 20701 | 72283 | 29859490 |
Diarrhoea | 34.71 | 15.77 | 117 | 20588 | 333986 | 29597787 |
Haemoptysis | 34.23 | 15.77 | 70 | 20635 | 31008 | 29900765 |
Therapy cessation | 34.10 | 15.77 | 47 | 20658 | 15090 | 29916683 |
Muscle enzyme increased | 31.75 | 15.77 | 10 | 20695 | 216 | 29931557 |
Base excess decreased | 31.62 | 15.77 | 10 | 20695 | 219 | 29931554 |
Sepsis | 31.33 | 15.77 | 33 | 20672 | 146362 | 29785411 |
Cheyne-Stokes respiration | 31.28 | 15.77 | 10 | 20695 | 227 | 29931546 |
Ventricular fibrillation | 31.13 | 15.77 | 45 | 20660 | 15093 | 29916680 |
Upper gastrointestinal haemorrhage | 30.90 | 15.77 | 55 | 20650 | 21973 | 29909800 |
Constipation | 30.90 | 15.77 | 20 | 20685 | 112886 | 29818887 |
Pericardial haemorrhage | 30.23 | 15.77 | 21 | 20684 | 2897 | 29928876 |
Arterial thrombosis | 29.80 | 15.77 | 16 | 20689 | 1390 | 29930383 |
Oxygen consumption decreased | 29.71 | 15.77 | 9 | 20696 | 170 | 29931603 |
Decreased appetite | 29.68 | 15.77 | 36 | 20669 | 149874 | 29781899 |
Mixed liver injury | 29.64 | 15.77 | 18 | 20687 | 1975 | 29929798 |
Drug abuse | 29.43 | 15.77 | 10 | 20695 | 82062 | 29849711 |
Troponin increased | 28.73 | 15.77 | 33 | 20672 | 8824 | 29922949 |
Intrapericardial thrombosis | 28.39 | 15.77 | 7 | 20698 | 58 | 29931715 |
Iron deficiency anaemia | 28.23 | 15.77 | 33 | 20672 | 8991 | 29922782 |
Cardiac tamponade | 27.50 | 15.77 | 24 | 20681 | 4620 | 29927153 |
Mallory-Weiss syndrome | 27.33 | 15.77 | 15 | 20690 | 1361 | 29930412 |
Disease progression | 26.52 | 15.77 | 11 | 20694 | 79863 | 29851910 |
Plasma cell myeloma | 26.45 | 15.77 | 3 | 20702 | 53459 | 29878314 |
Dehydration | 26.25 | 15.77 | 28 | 20677 | 123511 | 29808262 |
Brain natriuretic peptide increased | 26.23 | 15.77 | 22 | 20683 | 4013 | 29927760 |
Retroperitoneal haematoma | 25.71 | 15.77 | 18 | 20687 | 2514 | 29929259 |
Coronary artery dissection | 25.52 | 15.77 | 8 | 20697 | 170 | 29931603 |
Haemoglobin decreased | 25.42 | 15.77 | 150 | 20555 | 113948 | 29817825 |
Oedema peripheral | 24.79 | 15.77 | 22 | 20683 | 105810 | 29825963 |
Anterior interosseous syndrome | 24.47 | 15.77 | 5 | 20700 | 15 | 29931758 |
Atrioventricular block second degree | 24.40 | 15.77 | 19 | 20686 | 3121 | 29928652 |
Orthopnoea | 23.99 | 15.77 | 22 | 20683 | 4518 | 29927255 |
Nasopharyngitis | 23.23 | 15.77 | 6 | 20699 | 58843 | 29872930 |
Sinus node dysfunction | 23.04 | 15.77 | 20 | 20685 | 3823 | 29927950 |
Overdose | 22.98 | 15.77 | 15 | 20690 | 84322 | 29847451 |
Circumstance or information capable of leading to medication error | 22.49 | 15.77 | 14 | 20691 | 1605 | 29930168 |
Faeces discoloured | 22.42 | 15.77 | 37 | 20668 | 13909 | 29917864 |
Left ventricular enlargement | 22.41 | 15.77 | 10 | 20695 | 580 | 29931193 |
Ischaemic stroke | 22.01 | 15.77 | 40 | 20665 | 16235 | 29915538 |
Stent placement | 21.85 | 15.77 | 21 | 20684 | 4575 | 29927198 |
Hepatitis cholestatic | 21.70 | 15.77 | 27 | 20678 | 7845 | 29923928 |
Gout | 21.47 | 15.77 | 41 | 20664 | 17274 | 29914499 |
Seizure | 21.27 | 15.77 | 22 | 20683 | 98453 | 29833320 |
Reperfusion injury | 21.16 | 15.77 | 6 | 20699 | 89 | 29931684 |
Sleep apnoea syndrome | 21.01 | 15.77 | 40 | 20665 | 16817 | 29914956 |
Pancytopenia | 20.74 | 15.77 | 17 | 20688 | 85035 | 29846738 |
Hypertrophy | 20.57 | 15.77 | 8 | 20697 | 327 | 29931446 |
Cerebral haematoma | 20.28 | 15.77 | 20 | 20685 | 4494 | 29927279 |
Gastritis erosive | 20.06 | 15.77 | 22 | 20683 | 5591 | 29926182 |
Post procedural haemorrhage | 20.02 | 15.77 | 26 | 20679 | 7884 | 29923889 |
Walking disability | 20.00 | 15.77 | 10 | 20695 | 749 | 29931024 |
Hepatocellular injury | 19.82 | 15.77 | 50 | 20655 | 25421 | 29906352 |
Suffocation feeling | 19.66 | 15.77 | 9 | 20696 | 554 | 29931219 |
Asphyxia | 18.94 | 15.77 | 21 | 20684 | 5404 | 29926369 |
Microcytic anaemia | 18.73 | 15.77 | 14 | 20691 | 2164 | 29929609 |
Bladder tamponade | 18.62 | 15.77 | 8 | 20697 | 423 | 29931350 |
Hyperlipidaemia | 18.58 | 15.77 | 34 | 20671 | 13873 | 29917900 |
Duodenal ulcer | 18.30 | 15.77 | 28 | 20677 | 9873 | 29921900 |
Mean cell haemoglobin decreased | 18.29 | 15.77 | 11 | 20694 | 1186 | 29930587 |
Weight increased | 18.23 | 15.77 | 15 | 20690 | 74898 | 29856875 |
Platelet aggregation decreased | 18.13 | 15.77 | 4 | 20701 | 19 | 29931754 |
Myelofibrosis | 17.92 | 15.77 | 12 | 20693 | 1559 | 29930214 |
Myocardial ischaemia | 17.88 | 15.77 | 38 | 20667 | 17279 | 29914494 |
Platelet aggregation abnormal | 17.80 | 15.77 | 4 | 20701 | 21 | 29931752 |
Confusional state | 17.79 | 15.77 | 42 | 20663 | 134792 | 29796981 |
Calculus urinary | 17.68 | 15.77 | 11 | 20694 | 1260 | 29930513 |
Electrocardiogram abnormal | 17.52 | 15.77 | 21 | 20684 | 5871 | 29925902 |
Urinary bladder haemorrhage | 17.38 | 15.77 | 12 | 20693 | 1639 | 29930134 |
Neuropathy peripheral | 17.29 | 15.77 | 14 | 20691 | 70461 | 29861312 |
Intracardiac thrombus | 17.28 | 15.77 | 14 | 20691 | 2434 | 29929339 |
Pulmonary alveolar haemorrhage | 17.23 | 15.77 | 22 | 20683 | 6559 | 29925214 |
Autoimmune myositis | 17.07 | 15.77 | 4 | 20701 | 26 | 29931747 |
Electrocardiogram ST segment elevation | 16.91 | 15.77 | 18 | 20687 | 4424 | 29927349 |
Muscle necrosis | 16.83 | 15.77 | 9 | 20696 | 775 | 29930998 |
Cerebellar haemorrhage | 16.68 | 15.77 | 11 | 20694 | 1393 | 29930380 |
Ventricular tachycardia | 16.68 | 15.77 | 45 | 20660 | 23817 | 29907956 |
Gastric ulcer | 16.57 | 15.77 | 34 | 20671 | 15087 | 29916686 |
Product administration error | 16.56 | 15.77 | 33 | 20672 | 14344 | 29917429 |
Computerised tomogram head abnormal | 16.46 | 15.77 | 4 | 20701 | 31 | 29931742 |
Diverticulitis intestinal haemorrhagic | 16.44 | 15.77 | 7 | 20698 | 362 | 29931411 |
Back pain | 16.03 | 15.77 | 29 | 20676 | 102567 | 29829206 |
Source | Code | Description |
---|---|---|
ATC | B01AC24 | BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Platelet aggregation inhibitors excl. heparin |
FDA PE | N0000008832 | Decreased Platelet Aggregation |
MeSH PA | D006401 | Hematologic Agents |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D010975 | Platelet Aggregation Inhibitors |
MeSH PA | D058914 | Purinergic Antagonists |
MeSH PA | D058919 | Purinergic P2 Receptor Antagonists |
MeSH PA | D058921 | Purinergic P2Y Receptor Antagonists |
FDA MoA | N0000182141 | Cytochrome P450 3A4 Inhibitors |
FDA EPC | N0000182142 | P2Y12 Platelet Inhibitor |
FDA MoA | N0000182143 | P2Y12 Receptor Antagonists |
FDA MoA | N0000185503 | P-Glycoprotein Inhibitors |
FDA MoA | N0000190115 | Cytochrome P450 3A5 Inhibitors |
FDA MoA | N0000190482 | Phenylalanine Hydroxylase Activators |
CHEBI has role | CHEBI:50427 | platelet aggregation inhibitors |
CHEBI has role | CHEBI:68563 | purinergic receptor subtype p2y12 antagonist |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Acute coronary syndrome | indication | 394659003 | |
Peripheral vascular disease | indication | 400047006 | |
Percutaneous coronary intervention | indication | 415070008 | |
Myocardial Reinfarction Prevention | indication | ||
Intracranial hemorrhage | contraindication | 1386000 | |
Hepatic failure | contraindication | 59927004 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Surgical procedure | contraindication | 387713003 | |
Significant Bleeding | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 3.07 | Basic |
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
60MG | BRILINTA | ASTRAZENECA | N022433 | Sept. 3, 2015 | RX | TABLET | ORAL | May 28, 2023 | TO REDUCE THE RISK OF A FIRST MYOCARDIAL INFARCTION (MI) OR STROKE IN PATIENTS WITH CORONULLRY ARTERY DISEASE (CAD) AT HIGH RISK FOR SUCH EVENTS |
90MG | BRILINTA | ASTRAZENECA | N022433 | July 20, 2011 | RX | TABLET | ORAL | May 28, 2023 | TO REDUCE THE RISK OF A FIRST MYOCARDIAL INFARCTION (MI) OR STROKE IN PATIENTS WITH CORONULLRY ARTERY DISEASE (CAD) AT HIGH RISK FOR SUCH EVENTS |
60MG | BRILINTA | ASTRAZENECA | N022433 | Sept. 3, 2015 | RX | TABLET | ORAL | Nov. 5, 2023 | REDUCE THE RISK OF STROKE IN PATIENTS WITH ACUTE ISCHEMIC STROKE (NIH STROKE SCALE SCORE <=5) OR HIGH-RISK TRANSIENT ISCHEMIC ATTACK (TIA) |
90MG | BRILINTA | ASTRAZENECA | N022433 | July 20, 2011 | RX | TABLET | ORAL | Nov. 5, 2023 | REDUCE THE RISK OF STROKE IN PATIENTS WITH ACUTE ISCHEMIC STROKE (NIH STROKE SCALE SCORE <=5) OR HIGH-RISK TRANSIENT ISCHEMIC ATTACK (TIA) |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
P2Y purinoceptor 12 | GPCR | NEGATIVE ALLOSTERIC MODULATOR | Ki | 7.85 | CHEMBL | CHEMBL | |||
Equilibrative nucleoside transporter 1 | Transporter | INHIBITOR | Ki | 7.30 | IUPHAR | ||||
P2Y purinoceptor 12 | Unclassified | IC50 | 5.38 | CHEMBL |
ID | Source |
---|---|
4030908 | VUID |
N0000182973 | NUI |
D09017 | KEGG_DRUG |
4030908 | VANDF |
C1608718 | UMLSCUI |
CHEBI:68558 | CHEBI |
TIQ | PDB_CHEM_ID |
CHEMBL398435 | ChEMBL_ID |
D000077486 | MESH_DESCRIPTOR_UI |
9871419 | PUBCHEM_CID |
8772 | INN_ID |
DB08816 | DRUGBANK_ID |
GLH0314RVC | UNII |
1765 | IUPHAR_LIGAND_ID |
1116632 | RXNORM |
182026 | MMSL |
235692 | MMSL |
27677 | MMSL |
d07721 | MMSL |
013611 | NDDF |
698805004 | SNOMEDCT_US |
704464003 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
BRILINTA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-0776 | TABLET | 60 mg | ORAL | NDA | 31 sections |
BRILINTA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-0777 | TABLET | 90 mg | ORAL | NDA | 31 sections |
BRILINTA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55154-9618 | TABLET | 90 mg | ORAL | NDA | 28 sections |
ticagrelor | HUMAN PRESCRIPTION DRUG LABEL | 1 | 69238-1134 | TABLET | 90 mg | ORAL | ANDA | 28 sections |