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permethrin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4152 | 52645-53-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A pyrethroid insecticide commonly used in the treatment of LICE INFESTATIONS and SCABIES.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 60 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,GRK2,GSK3B,ITK,MAP2K6,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CG,PRKDC,STK33,TEK,TTK | 32 | |||
| kinase-selectivity-class | GRK2,RIPK1 | 2 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 31, 1986 | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Pregnancy with injectable contraceptive | 52.22 | 30.92 | 7 | 949 | 134 | 90627357 |
| Acarodermatitis | 42.49 | 30.92 | 8 | 948 | 1378 | 90626113 |
| Pruritus | 38.36 | 30.92 | 37 | 919 | 541488 | 90086003 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Ejaculation failure | 48.45 | 47.15 | 8 | 346 | 833 | 42620148 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Acarodermatitis | 63.93 | 26.54 | 12 | 1193 | 1969 | 110586125 |
| Pregnancy with injectable contraceptive | 53.42 | 26.54 | 7 | 1198 | 108 | 110587986 |
| Ejaculation failure | 52.40 | 26.54 | 8 | 1197 | 380 | 110587714 |
| Dry skin | 46.82 | 26.54 | 23 | 1182 | 107630 | 110480464 |
| Pruritus | 42.40 | 26.54 | 41 | 1164 | 581519 | 110006575 |
| Delusion of parasitosis | 32.26 | 26.54 | 5 | 1200 | 262 | 110587832 |
| Hidradenitis | 26.82 | 26.54 | 7 | 1198 | 5173 | 110582921 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | P03AC04 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS ECTOPARASITICIDES, INCL. SCABICIDES Pyrethrines, incl. synthetic compounds |
| ATC | P03AC54 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS ECTOPARASITICIDES, INCL. SCABICIDES Pyrethrines, incl. synthetic compounds |
| FDA CS | M0018228 | Pyrethrins |
| FDA EPC | N0000175847 | Pyrethroid |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D007306 | Insecticides |
| MeSH PA | D010575 | Pesticides |
| CHEBI has role | CHEBI:33286 | agrochemical |
| CHEBI has role | CHEBI:35442 | antiparasitic agent |
| CHEBI has role | CHEBI:36047 | antibacterial drug |
| CHEBI has role | CHEBI:38956 | ectoparasiticide |
| CHEBI has role | CHEBI:39116 | pyrethroid ester insecticide |
| CHEBI has role | CHEBI:39259 | pyrethroid ester acaricide |
| CHEBI has role | CHEBI:73333 | scabicide |
Related Drugs by ATC class:
P03AC Pyrethrines, incl. synthetic compounds 3 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Pediculosis corporis | indication | 25188002 | DOID:5513 |
| Infestation by Phthirus pubis | indication | 71011005 | DOID:13760 |
| Pediculosis capitis | indication | 81000006 | DOID:5501 |
| Infestation by Sarcoptes scabiei var hominis | indication | 128869009 | DOID:8295 |
| Pediculosis Prevention | indication | ||
| Bronchospasm | contraindication | 4386001 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sodium channel protein | Ion channel | BLOCKER | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018775 | VUID |
| N0000147078 | NUI |
| D05443 | KEGG_DRUG |
| 4018775 | VANDF |
| C0070455 | UMLSCUI |
| CHEBI:34911 | CHEBI |
| CHEMBL1525 | ChEMBL_ID |
| D026023 | MESH_DESCRIPTOR_UI |
| DB04930 | DRUGBANK_ID |
| 5510 | INN_ID |
| 509F88P9SZ | UNII |
| 40326 | PUBCHEM_CID |
| 33199 | RXNORM |
| 41581 | MMSL |
| 5260 | MMSL |
| 003009 | NDDF |
| 1887004 | SNOMEDCT_US |
| 410457007 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| good sense lice killing creme rinse | HUMAN OTC DRUG LABEL | 1 | 0113-1910 | LOTION | 1 mg | TOPICAL | ANDA | 16 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0472-0242 | CREAM | 50 mg | TOPICAL | ANDA | 12 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-897 | CREAM | 50 mg | TOPICAL | ANDA | 20 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-907 | CREAM | 50 mg | TOPICAL | ANDA | 20 sections |
| Permethrin | Human Prescription Drug Label | 1 | 21922-021 | CREAM | 50 mg | TOPICAL | ANDA | 18 sections |
| Permethrin | Human Prescription Drug Label | 1 | 21922-021 | CREAM | 50 mg | TOPICAL | ANDA | 18 sections |
| Topcare lice killing creme rinse | HUMAN OTC DRUG LABEL | 1 | 36800-629 | LOTION | 1 mg | TOPICAL | ANDA | 16 sections |
| Lice Treatment | HUMAN OTC DRUG LABEL | 1 | 42254-065 | LOTION | 1 mg | TOPICAL | ANDA | 16 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43598-481 | CREAM | 50 mg | TOPICAL | ANDA | 21 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45802-269 | CREAM | 50 mg | TOPICAL | ANDA | 20 sections |
| Permethrin | Human Prescription Drug Label | 1 | 50090-5888 | CREAM | 50 mg | TOPICAL | ANDA | 18 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52959-159 | CREAM | 50 mg | TOPICAL | ANDA | 21 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53002-9570 | CREAM | 50 mg | TOPICAL | ANDA | 20 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53002-9571 | CREAM | 50 mg | TOPICAL | ANDA | 18 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-5391 | CREAM | 50 mg | TOPICAL | ANDA | 21 sections |
| ELIMITE | Human Prescription Drug Label | 1 | 59651-834 | CREAM | 50 mg | TOPICAL | NDA | 19 sections |
| Nix Lice Killing Creme Rinse | HUMAN OTC DRUG LABEL | 1 | 63471-3006 | RINSE | 1 g | TOPICAL | NDA | 15 sections |
| Nix | HUMAN OTC DRUG LABEL | 1 | 63736-024 | SHAMPOO | 560 mg | TOPICAL | NDA | 16 sections |
| Nix | HUMAN OTC DRUG LABEL | 1 | 63736-030 | RINSE | 1 g | TOPICAL | NDA | 16 sections |
| Nix | HUMAN OTC DRUG LABEL | 1 | 63736-030 | RINSE | 1 g | TOPICAL | NDA | 16 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 67296-1057 | CREAM | 50 mg | TOPICAL | ANDA | 20 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 67296-1058 | CREAM | 50 mg | TOPICAL | ANDA | 12 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68071-1627 | CREAM | 50 mg | TOPICAL | ANDA | 18 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68788-8439 | CREAM | 50 mg | TOPICAL | ANDA | 18 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70518-2945 | CREAM | 50 mg | TOPICAL | ANDA | 18 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 71335-2899 | CREAM | 50 mg | TOPICAL | ANDA | 20 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 72162-2171 | CREAM | 50 mg | TOPICAL | ANDA | 20 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 76413-122 | CREAM | 50 mg | TOPICAL | ANDA | 21 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 76413-159 | CREAM | 50 mg | TOPICAL | ANDA | 12 sections |
| Permethrin | HUMAN OTC DRUG LABEL | 1 | 76413-320 | LOTION | 1 mg | TOPICAL | ANDA | 15 sections |