permethrin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4152 | 52645-53-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A pyrethroid insecticide commonly used in the treatment of LICE INFESTATIONS and SCABIES.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 60 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 31, 1986 | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Pregnancy with injectable contraceptive | 52.42 | 35.43 | 7 | 650 | 133 | 63488232 |
| Acarodermatitis | 38.11 | 35.43 | 7 | 650 | 1076 | 63487289 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Ejaculation failure | 54.97 | 40.23 | 8 | 128 | 801 | 34955994 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Pregnancy with injectable contraceptive | 55.13 | 30.47 | 7 | 681 | 107 | 79743593 |
| Ejaculation failure | 54.77 | 30.47 | 8 | 680 | 357 | 79743343 |
| Acarodermatitis | 44.04 | 30.47 | 8 | 680 | 1390 | 79742310 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | P03AC04 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS ECTOPARASITICIDES, INCL. SCABICIDES Pyrethrines, incl. synthetic compounds |
| ATC | P03AC54 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS ECTOPARASITICIDES, INCL. SCABICIDES Pyrethrines, incl. synthetic compounds |
| FDA CS | M0018228 | Pyrethrins |
| FDA EPC | N0000175847 | Pyrethroid |
| CHEBI has role | CHEBI:33286 | agricultural chemicals |
| CHEBI has role | CHEBI:38956 | ectoparasiticides |
| CHEBI has role | CHEBI:39116 | pyrethroid ester insecticides |
| CHEBI has role | CHEBI:73333 | scabicides |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D007306 | Insecticides |
| MeSH PA | D010575 | Pesticides |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Pediculosis corporis | indication | 25188002 | DOID:5513 |
| Infestation by Phthirus pubis | indication | 71011005 | DOID:13760 |
| Pediculosis capitis | indication | 81000006 | DOID:5501 |
| Infestation by Sarcoptes scabiei var hominis | indication | 128869009 | DOID:8295 |
| Pediculosis Prevention | indication | ||
| Bronchospasm | contraindication | 4386001 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sodium channel protein | Ion channel | BLOCKER | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018775 | VUID |
| N0000147078 | NUI |
| D05443 | KEGG_DRUG |
| 4018775 | VANDF |
| C0070455 | UMLSCUI |
| CHEBI:34911 | CHEBI |
| CHEMBL1525 | ChEMBL_ID |
| D026023 | MESH_DESCRIPTOR_UI |
| DB04930 | DRUGBANK_ID |
| 5510 | INN_ID |
| 509F88P9SZ | UNII |
| 40326 | PUBCHEM_CID |
| 33199 | RXNORM |
| 41581 | MMSL |
| 5260 | MMSL |
| 003009 | NDDF |
| 1887004 | SNOMEDCT_US |
| 410457007 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| good sense lice killing creme rinse | HUMAN OTC DRUG LABEL | 1 | 0113-1910 | LOTION | 1 mg | TOPICAL | ANDA | 16 sections |
| good sense lice killing creme rinse | HUMAN OTC DRUG LABEL | 1 | 0113-1910 | LOTION | 1 mg | TOPICAL | ANDA | 16 sections |
| lice treatment | HUMAN OTC DRUG LABEL | 1 | 0363-0955 | LOTION | 1 mg | TOPICAL | ANDA | 16 sections |
| lice treatment | HUMAN OTC DRUG LABEL | 1 | 0363-0955 | LOTION | 1 mg | TOPICAL | ANDA | 16 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0472-0242 | CREAM | 50 mg | TOPICAL | ANDA | 12 sections |
| lice treatment | HUMAN OTC DRUG LABEL | 1 | 11822-0549 | LOTION | 1 mg | TOPICAL | ANDA | 16 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-897 | CREAM | 50 mg | TOPICAL | ANDA | 20 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-897 | CREAM | 50 mg | TOPICAL | ANDA | 20 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-907 | CREAM | 50 mg | TOPICAL | ANDA | 20 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21922-021 | CREAM | 50 mg | TOPICAL | ANDA | 18 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21922-021 | CREAM | 50 mg | TOPICAL | ANDA | 18 sections |
| Topcare lice killing creme rinse | HUMAN OTC DRUG LABEL | 1 | 36800-629 | LOTION | 1 mg | TOPICAL | ANDA | 16 sections |
| Lice Treatment | HUMAN OTC DRUG LABEL | 1 | 42254-065 | LOTION | 1 mg | TOPICAL | ANDA | 16 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45802-269 | CREAM | 50 mg | TOPICAL | ANDA | 20 sections |
| good neighbor pharmacy lice treatment | HUMAN OTC DRUG LABEL | 1 | 46122-108 | LOTION | 1 mg | TOPICAL | ANDA | 16 sections |
| sunmark lice treatment | HUMAN OTC DRUG LABEL | 1 | 49348-150 | LOTION | 1 mg | TOPICAL | ANDA | 16 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-3149 | CREAM | 50 mg | TOPICAL | ANDA | 20 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-3149 | CREAM | 50 mg | TOPICAL | ANDA | 20 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-5888 | CREAM | 50 mg | TOPICAL | ANDA | 18 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52959-159 | CREAM | 50 mg | TOPICAL | ANDA | 21 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53002-9570 | CREAM | 50 mg | TOPICAL | ANDA | 20 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53002-9570 | CREAM | 50 mg | TOPICAL | ANDA | 20 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53002-9571 | CREAM | 50 mg | TOPICAL | ANDA | 18 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53002-9571 | CREAM | 50 mg | TOPICAL | ANDA | 18 sections |
| Permethrin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-5391 | CREAM | 50 mg | TOPICAL | ANDA | 21 sections |
| Lice Treatment | HUMAN OTC DRUG LABEL | 1 | 59779-769 | LOTION | 1 mg | TOPICAL | ANDA | 16 sections |
| health mart lice treatment | HUMAN OTC DRUG LABEL | 1 | 62011-0255 | LOTION | 1 mg | TOPICAL | ANDA | 16 sections |
| Nix Lice Killing Creme Rinse | HUMAN OTC DRUG LABEL | 1 | 63471-3006 | RINSE | 1 g | TOPICAL | NDA | 15 sections |
| Nix | HUMAN OTC DRUG LABEL | 1 | 63736-024 | SHAMPOO | 1 g | TOPICAL | NDA | 32 sections |
| Nix | HUMAN OTC DRUG LABEL | 1 | 63736-024 | SHAMPOO | 560 mg | TOPICAL | NDA | 32 sections |