gadoversetamide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diagnostic agents, gadolinium derivatives 4147 131069-91-5

Description:

MoleculeDescription

Synonyms:

  • gadoversetamide
  • optimark
nonionic, linear chelate used for magnetic resonance imaging of brain and spine
  • Molecular weight: 661.77
  • Formula: C20H34GdN5O10
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.16 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.20 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 1 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.70 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 23, 2007 EMA
Dec. 8, 1999 FDA LIEBEL-FLARSHEIM

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Nephrogenic systemic fibrosis 862.17 48.23 152 2080 4615 53342219
Skin induration 284.10 48.23 56 2176 3074 53343760
Skin hypertrophy 282.88 48.23 56 2176 3143 53343691
Skin tightness 252.30 48.23 53 2179 3998 53342836
Fibrosis 174.18 48.23 39 2193 3953 53342881
Skin fibrosis 149.59 48.23 27 2205 912 53345922
Skin hyperpigmentation 115.63 48.23 30 2202 5642 53341192
Scar 112.39 48.23 35 2197 12658 53334176
Joint range of motion decreased 112.16 48.23 38 2194 17918 53328916
Emotional distress 90.42 48.23 38 2194 32279 53314555
Joint contracture 86.41 48.23 19 2213 1765 53345069
Skin discolouration 84.05 48.23 37 2195 35155 53311679
Peau d'orange 77.21 48.23 12 2220 158 53346676
Anhedonia 76.18 48.23 25 2207 10662 53336172
Joint stiffness 69.58 48.23 31 2201 30252 53316582
Mobility decreased 67.20 48.23 41 2191 76230 53270604
Deformity 66.47 48.23 21 2211 7933 53338901
Oedema peripheral 56.81 48.23 51 2181 170736 53176098
Pain 54.94 48.23 92 2140 588306 52758528
Skin plaque 49.51 48.23 16 2216 6488 53340346
Injury 48.99 48.23 29 2203 50942 53295892

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Nephrogenic systemic fibrosis 693.95 75.39 128 1494 4224 32507680
Skin tightness 228.83 75.39 45 1577 2042 32509862
Skin induration 225.90 75.39 45 1577 2183 32509721
Skin hypertrophy 218.78 75.39 45 1577 2566 32509338
Joint range of motion decreased 145.68 75.39 38 1584 6144 32505760
Joint contracture 130.99 75.39 28 1594 1915 32509989
Fibrosis 128.75 75.39 29 1593 2528 32509376
Scar 128.17 75.39 34 1588 5859 32506045
Extremity contracture 116.89 75.39 22 1600 784 32511120
Skin fibrosis 110.59 75.39 22 1600 1052 32510852
Emotional distress 101.64 75.39 36 1586 16270 32495634
Deformity 96.26 75.39 21 1601 1577 32510327
Mobility decreased 88.81 75.39 38 1584 28371 32483533
Anhedonia 77.64 75.39 25 1597 8439 32503465

Pharmacologic Action:

SourceCodeDescription
ATC V08CA06 VARIOUS
CONTRAST MEDIA
MAGNETIC RESONANCE IMAGING CONTRAST MEDIA
Paramagnetic contrast media
MeSH PA D003287 Contrast Media
MeSH PA D064907 Diagnostic Uses of Chemicals
FDA MoA N0000175862 Magnetic Resonance Contrast Activity
FDA EPC N0000180184 Paramagnetic Contrast Agent

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Magnetic resonance imaging indication 113091000

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4021217 VUID
N0000148663 NUI
D01646 KEGG_DRUG
4021217 VANDF
C0754820 UMLSCUI
CHEBI:31644 CHEBI
CHEMBL1200457 ChEMBL_ID
DB00538 DRUGBANK_ID
C112666 MESH_SUPPLEMENTAL_RECORD_UI
7261 INN_ID
RLM74T3Z9D UNII
444013 PUBCHEM_CID
228833 RXNORM
31825 MMSL
8730 MMSL
d04515 MMSL
009502 NDDF
409476008 SNOMEDCT_US
409477004 SNOMEDCT_US

Pharmaceutical products:

None