testosterone propionate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
androgens/anabolic steroids 4146 57-85-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • virormone
  • testosterone propionate
An ester of TESTOSTERONE with a propionate substitution at the 17-beta position.
  • Molecular weight: 344.50
  • Formula: C22H32O3
  • CLOGP: 4.88
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 43.37
  • ALOGS: -4.84
  • ROTB: 3
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 2, 1974 FDA WATSON LABS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA CS M0001109 Androstanes
FDA MoA N0000000146 Androgen Receptor Agonists
MeSH PA D000728 Androgens
MeSH PA D006728 Hormones
FDA EPC N0000175824 Androgen
CHEBI has role CHEBI:50113 androgene
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:83056 Daphnia magna metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Deficiency of testosterone biosynthesis indication 38825009
Male hypogonadism indication 48723006
Undescended testicle indication 204878001 DOID:11383
Delayed puberty indication 400003000
Klinefelter's syndrome, XXY indication 405769009
Hormone receptor positive malignant neoplasm of breast indication 417181009
LHRH Deficiency indication
Gynecomastia contraindication 4754008 DOID:12698
Hypercholesterolemia contraindication 13644009
Humoral hypercalcemia of malignancy contraindication 47709007
Chronic heart failure contraindication 48447003
Heart disease contraindication 56265001 DOID:114
Diabetes mellitus contraindication 73211009 DOID:9351
Sleep apnea contraindication 73430006 DOID:0050847
Kidney disease contraindication 90708001 DOID:557
Neoplasm of prostate contraindication 126906006 DOID:10283
Disease of liver contraindication 235856003 DOID:409
Benign prostatic hyperplasia contraindication 266569009
Edema contraindication 267038008
Pregnancy, function contraindication 289908002
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Obesity contraindication 414916001 DOID:9970
Breast Carcinoma in Males contraindication




🐶 Veterinary Drug Use

SpeciesUseRelation
Cattle To increase rate of weight gain Indication
Cattle To improve feed efficiency Indication

🐶 Veterinary products

ProductApplicantIngredients
Synovex H Zoetis Inc. 2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Androgen receptor Nuclear hormone receptor AGONIST Ki 9.60 CHEMBL CHEMBL
Steroid 17-alpha-hydroxylase/17,20 lyase Enzyme IC50 7.25 CHEMBL
Androgen receptor Transcription factor IC50 5.72 CHEMBL

External reference:

IDSource
4017481 VUID
N0000145869 NUI
D00959 KEGG_DRUG
4017481 VANDF
4017484 VANDF
C0039607 UMLSCUI
CHEBI:9466 CHEBI
CHEBI:17347 CHEBI
TES PDB_CHEM_ID
CHEMBL1170 ChEMBL_ID
D043343 MESH_DESCRIPTOR_UI
DB01420 DRUGBANK_ID
7100 IUPHAR_LIGAND_ID
WI93Z9138A UNII
5995 PUBCHEM_CID
DB00624 DRUGBANK_ID
10379 RXNORM
2966 MMSL
3050 MMSL
5552 MMSL
5555 MMSL
d00558 MMSL
001245 NDDF
001248 NDDF
109033004 SNOMEDCT_US
43688007 SNOMEDCT_US
96338002 SNOMEDCT_US
C0039601 UMLSCUI
1900 INN_ID
6013 PUBCHEM_CID
D013739 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None