sulfadiazine silver Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-infectives, sulfonamides 4142 22199-08-2

Description:

MoleculeDescription

Synonyms:

  • sulfadiazine silver
  • silvadene
  • silver sulfadiazine
  • sulfadiazine, silver
Antibacterial used topically in burn therapy.
  • Molecular weight: 357.14
  • Formula: C10H9AgN4O2S
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Nov. 26, 1973 FDA KING PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 83.05 74.12 20 33 46623 2311409

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC D06BA01 DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
CHEMOTHERAPEUTICS FOR TOPICAL USE
Sulfonamides
ATC D06BA51 DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
CHEMOTHERAPEUTICS FOR TOPICAL USE
Sulfonamides
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
CHEBI has role CHEBI:36047 antibacterial drug
FDA EPC N0000175503 Sulfonamide Antibacterial
FDA CS M0020790 Sulfonamides

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Skin ulcer indication 46742003
Burn Wound Infections indication
Minor Bacterial Skin Infections indication
Leukopenia contraindication 84828003 DOID:615
Kidney disease contraindication 90708001 DOID:557
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Superimposed infection contraindication 193198003
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Porphyria contraindication 418470004

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Aurora kinase A Kinase IC50 4.68 CHEMBL
Dihydropteroate synthase Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
4018504 VUID
N0000146826 NUI
C0037134 UMLSCUI
D00433 KEGG_DRUG
19630009 SNOMEDCT_US
4018504 VANDF
1649 MMSL
387112002 SNOMEDCT_US
5463 MMSL
003135 NDDF
9793 RXNORM
CHEMBL439 ChEMBL_ID
CHEMBL1200766 ChEMBL_ID
W46JY43EJR UNII
DB05245 DRUGBANK_ID
CHEBI:9142 CHEBI
CHEMBL1382627 ChEMBL_ID
D012837 MESH_DESCRIPTOR_UI
441244 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 0440-0124 CREAM 10 mg TOPICAL NDA 16 sections
SSD HUMAN PRESCRIPTION DRUG LABEL 1 16590-206 CREAM 10 g TOPICAL NDA 11 sections
Thermazene HUMAN PRESCRIPTION DRUG LABEL 1 21695-182 CREAM 10 mg TOPICAL NDA 11 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 33261-589 CREAM 10 mg TOPICAL NDA 16 sections
Silver Sulfadiazene HUMAN PRESCRIPTION DRUG LABEL 1 42254-118 CREAM 10 g TOPICAL NDA 10 sections
SSD Cream HUMAN PRESCRIPTION DRUG LABEL 1 43598-210 CREAM 10 g TOPICAL NDA 11 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 45865-642 CREAM 10 mg TOPICAL NDA 16 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 49999-185 CREAM 10 g TOPICAL ANDA 11 sections
SILVADENE HUMAN PRESCRIPTION DRUG LABEL 1 50090-0230 CREAM 10 mg TOPICAL NDA 11 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 50090-0763 CREAM 10 mg TOPICAL NDA 15 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 50436-1240 CREAM 10 mg TOPICAL NDA 16 sections
Silver Sulfadiazene HUMAN PRESCRIPTION DRUG LABEL 1 50436-3099 CREAM 10 g TOPICAL NDA 10 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 52959-635 CREAM 10 g TOPICAL NDA 10 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 53002-9090 CREAM 10 mg TOPICAL NDA 16 sections
Thermazene HUMAN PRESCRIPTION DRUG LABEL 1 53097-101 CREAM 10 mg TOPICAL NDA 16 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 54868-0375 CREAM 10 mg TOPICAL NDA 10 sections
SSD Cream HUMAN PRESCRIPTION DRUG LABEL 1 55700-640 CREAM 10 g TOPICAL NDA 10 sections
SILVER SULFADIAZINE HUMAN PRESCRIPTION DRUG LABEL 1 59762-0131 CREAM 10 mg TOPICAL NDA AUTHORIZED GENERIC 12 sections
SILVADENE HUMAN PRESCRIPTION DRUG LABEL 1 61570-131 CREAM 10 mg TOPICAL NDA 11 sections
SILVER SULFADIAZINE HUMAN PRESCRIPTION DRUG LABEL 1 61919-206 CREAM 10 mg TOPICAL NDA 12 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 61919-237 CREAM 10 g TOPICAL NDA 11 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 63187-023 CREAM 10 mg TOPICAL NDA 16 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 66267-943 CREAM 10 mg TOPICAL NDA 16 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 67877-124 CREAM 10 mg TOPICAL NDA 15 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 68071-1333 CREAM 10 mg TOPICAL NDA 16 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 68071-1334 CREAM 10 mg TOPICAL NDA 16 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 68071-4481 CREAM 10 mg TOPICAL NDA 16 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 68387-450 CREAM 10 mg TOPICAL ANDA 11 sections
Thermazene HUMAN PRESCRIPTION DRUG LABEL 1 68788-0600 CREAM 10 mg TOPICAL NDA 15 sections
Thermazene HUMAN PRESCRIPTION DRUG LABEL 1 68788-9818 CREAM 10 mg TOPICAL NDA 11 sections