sulfadiazine silver 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
anti-infectives, sulfonamides 4142 22199-08-2

Description:

MoleculeDescription

Synonyms:

  • sulfadiazine silver
  • silvadene
  • silver sulfadiazine
  • sulfadiazine, silver
Antibacterial used topically in burn therapy.
  • Molecular weight: 357.14
  • Formula: C10H9AgN4O2S
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Nov. 26, 1973 FDA KING PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 222.13 17.22 160 3090 463449 90161748
PRIDE syndrome 30.51 17.22 4 3246 16 90625181
SJS-TEN overlap 29.25 17.22 7 3243 1101 90624096
Tumour necrosis factor receptor-associated periodic syndrome 24.07 17.22 4 3246 96 90625101
Cellulitis 21.34 17.22 21 3229 91316 90533881
Oral lichen planus 20.89 17.22 5 3245 786 90624411
Pyoderma gangrenosum 19.61 17.22 7 3243 4457 90620740
Oral fungal infection 17.62 17.22 6 3244 3326 90621871

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 90.52 23.63 55 1777 99334 42520169
Toxic epidermal necrolysis 89.47 23.63 36 1796 26714 42592789
Skin graft failure 34.53 23.63 6 1826 157 42619346
Thermal burn 25.29 23.63 8 1824 2946 42616557

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 210.72 18.28 161 4265 453929 110130944
Toxic epidermal necrolysis 77.19 18.28 40 4386 56687 110528186
Cellulitis 34.12 18.28 33 4393 125983 110458890
Skin graft failure 32.39 18.28 6 4420 244 110584629
PRIDE syndrome 28.45 18.28 4 4422 26 110584847
SJS-TEN overlap 24.83 18.28 7 4419 1867 110583006
Tumour necrosis factor receptor-associated periodic syndrome 23.84 18.28 4 4422 91 110584782
Skin ulcer 23.80 18.28 20 4406 63625 110521248
Skin infection 22.62 18.28 13 4413 22496 110562377
Oral lichen planus 19.56 18.28 5 4421 922 110583951

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D06BA01 DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
CHEMOTHERAPEUTICS FOR TOPICAL USE
Sulfonamides
ATC D06BA51 DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
CHEMOTHERAPEUTICS FOR TOPICAL USE
Sulfonamides
FDA CS M0020790 Sulfonamides
FDA EPC N0000175503 Sulfonamide Antibacterial
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
CHEBI has role CHEBI:33281 antibiotics
CHEBI has role CHEBI:36047 antibacterial drugs

Related Drugs by ATC class:

D06BA Sulfonamides 5 drugs
mafenidesulfamerazinesulfamethizolesulfanilamidesulfathiazole

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Skin ulcer indication 46742003
Burn Wound Infections indication
Minor Bacterial Skin Infections indication
Leukopenia contraindication 84828003 DOID:615
Kidney disease contraindication 90708001 DOID:557
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Superimposed infection contraindication 193198003
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Porphyria contraindication 418470004




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Otitis externa complicated by bacterial and fungal organisms Indication

🐶 Veterinary products

ProductApplicantIngredients
Baytril Otic Elanco US Inc. 2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Aurora kinase A Kinase IC50 4.68 CHEMBL
Dihydropteroate synthase Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
4018504 VUID
N0000146826 NUI
D00433 KEGG_DRUG
4018504 VANDF
C0037134 UMLSCUI
CHEMBL1382627 ChEMBL_ID
441244 PUBCHEM_CID
DB05245 DRUGBANK_ID
224926 RXNORM
1640 MMSL
1649 MMSL
5463 MMSL
003135 NDDF
19630009 SNOMEDCT_US
387112002 SNOMEDCT_US
D012837 MESH_DESCRIPTOR_UI
CHEBI:9142 CHEBI
W46JY43EJR UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 0440-0124 CREAM 10 mg TOPICAL NDA 17 sections
SSD HUMAN PRESCRIPTION DRUG LABEL 1 16590-206 CREAM 10 g TOPICAL NDA 14 sections
ThermazeneSilver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 21695-182 CREAM 10 mg TOPICAL NDA 11 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 33261-589 CREAM 10 mg TOPICAL NDA 16 sections
Silver Sulfadiazene HUMAN PRESCRIPTION DRUG LABEL 1 42254-118 CREAM 10 g TOPICAL NDA 16 sections
SSD Cream HUMAN PRESCRIPTION DRUG LABEL 1 43598-210 CREAM 10 g TOPICAL NDA 11 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 45865-642 CREAM 10 mg TOPICAL NDA 17 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 49999-185 CREAM 10 g TOPICAL ANDA 19 sections
SILVADENE HUMAN PRESCRIPTION DRUG LABEL 1 50090-0230 CREAM 10 mg TOPICAL NDA 19 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 50090-0607 CREAM 10 mg TOPICAL NDA 17 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 50090-0717 CREAM 10 mg TOPICAL NDA 17 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 50090-0763 CREAM 10 mg TOPICAL NDA 17 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 50090-2152 CREAM 10 mg TOPICAL NDA 17 sections
SSD HUMAN PRESCRIPTION DRUG LABEL 1 50090-7447 CREAM 10 g TOPICAL NDA 11 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 50436-1240 CREAM 10 mg TOPICAL NDA 17 sections
Silver Sulfadiazene HUMAN PRESCRIPTION DRUG LABEL 1 50436-3099 CREAM 10 g TOPICAL NDA 16 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 52959-635 CREAM 10 g TOPICAL NDA 14 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 53002-9090 CREAM 10 mg TOPICAL NDA 17 sections
SSD HUMAN PRESCRIPTION DRUG LABEL 1 53002-9091 CREAM 10 g TOPICAL NDA 11 sections
Thermazene HUMAN PRESCRIPTION DRUG LABEL 1 53097-101 CREAM 10 mg TOPICAL NDA 17 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 54868-0375 CREAM 10 mg TOPICAL NDA 14 sections
SILVER SULFADIAZINE HUMAN PRESCRIPTION DRUG LABEL 1 59762-0131 CREAM 10 mg TOPICAL NDA AUTHORIZED GENERIC 21 sections
SSD Cream HUMAN PRESCRIPTION DRUG LABEL 1 60760-962 CREAM 10 g TOPICAL NDA 10 sections
SILVADENE HUMAN PRESCRIPTION DRUG LABEL 1 61570-131 CREAM 10 mg TOPICAL NDA 19 sections
SILVER SULFADIAZINE HUMAN PRESCRIPTION DRUG LABEL 1 61919-206 CREAM 10 mg TOPICAL NDA 12 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 61919-237 CREAM 10 g TOPICAL NDA 11 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 63187-023 CREAM 10 mg TOPICAL NDA 17 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 63629-8768 CREAM 10 mg TOPICAL NDA 16 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 63629-8769 CREAM 10 mg TOPICAL NDA 16 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 63629-8770 CREAM 10 mg TOPICAL NDA 16 sections