sulfadiazine silver 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anti-infectives, sulfonamides	4142	22199-08-2

Description:

Molecule	Description
Synonyms: sulfadiazine silver silvadene silver sulfadiazine sulfadiazine, silver	Antibacterial used topically in burn therapy. Molecular weight: 357.14 Formula: C10H9AgN4O2S CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

sulfadiazine silver
silvadene
silver sulfadiazine
sulfadiazine, silver

Antibacterial used topically in burn therapy.

Molecular weight: 357.14
Formula: C10H9AgN4O2S
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Nov. 26, 1973	FDA	KING PHARMS

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	238.62	18.41	155	2640	310532	63175695
PRIDE syndrome	29.69	18.41	4	2791	16	63486211
Tumour necrosis factor receptor-associated periodic syndrome	23.68	18.41	4	2791	86	63486141
Oral lichen planus	20.58	18.41	5	2790	681	63485546
Cellulitis	19.65	18.41	21	2774	81937	63404290
Pyoderma gangrenosum	19.64	18.41	7	2788	3618	63482609

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	98.59	24.31	54	1451	80475	34874951
Toxic epidermal necrolysis	96.89	24.31	36	1469	21610	34933816
Skin graft failure	28.34	24.31	5	1500	143	34955283

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	232.77	19.62	155	3622	298761	79441850
Toxic epidermal necrolysis	74.11	19.62	38	3739	44543	79696068
Cellulitis	31.62	19.62	32	3745	109028	79631583
PRIDE syndrome	29.20	19.62	4	3773	17	79740594
Skin graft failure	25.62	19.62	5	3772	227	79740384
Tumour necrosis factor receptor-associated periodic syndrome	23.38	19.62	4	3773	86	79740525
Skin infection	20.45	19.62	12	3765	18233	79722378
Skin ulcer	19.67	19.62	18	3759	54132	79686479

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	D06BA01	DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE CHEMOTHERAPEUTICS FOR TOPICAL USE Sulfonamides
ATC	D06BA51	DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE CHEMOTHERAPEUTICS FOR TOPICAL USE Sulfonamides
CHEBI has role	CHEBI:33281	antibiotics
CHEBI has role	CHEBI:36047	antibacterial drugs
FDA CS	M0020790	Sulfonamides
FDA EPC	N0000175503	Sulfonamide Antibacterial
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Skin ulcer	indication	46742003
Burn Wound Infections	indication
Minor Bacterial Skin Infections	indication
Leukopenia	contraindication	84828003	DOID:615
Kidney disease	contraindication	90708001	DOID:557
Anemia due to enzyme deficiency	contraindication	111577008
Deficiency of glucose-6-phosphate dehydrogenase	contraindication	124134002	DOID:2862
Superimposed infection	contraindication	193198003
Disease of liver	contraindication	235856003	DOID:409
Anemia	contraindication	271737000	DOID:2355

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🐶 Veterinary Drug Use

Species	Use	Relation
Dogs	Otitis externa complicated by bacterial and fungal organisms	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Baytril Otic	Elanco US Inc.	2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Aurora kinase A	Kinase	O14965	AURKA_HUMAN		IC50	4.68		CHEMBL
Dihydropteroate synthase	Enzyme		DHPS_ECOLI	INHIBITOR				CHEMBL	CHEMBL

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External reference:

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ID	Source
003135	NDDF
1640	MMSL
1649	MMSL
19630009	SNOMEDCT_US
224926	RXNORM
387112002	SNOMEDCT_US
4018504	VUID
4018504	VANDF
441244	PUBCHEM_CID
5463	MMSL

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
SILVADENE	HUMAN PRESCRIPTION DRUG LABEL	1	50090-0230	CREAM	10 mg	TOPICAL	NDA	19 sections
SILVADENE	HUMAN PRESCRIPTION DRUG LABEL	1	50090-0230	CREAM	10 mg	TOPICAL	NDA	19 sections
SILVADENE	HUMAN PRESCRIPTION DRUG LABEL	1	61570-131	CREAM	10 mg	TOPICAL	NDA	19 sections
Silver Sulfadiazene	HUMAN PRESCRIPTION DRUG LABEL	1	42254-118	CREAM	10 g	TOPICAL	NDA	16 sections
Silver Sulfadiazene	HUMAN PRESCRIPTION DRUG LABEL	1	50436-3099	CREAM	10 g	TOPICAL	NDA	16 sections
Silver Sulfadiazine	HUMAN PRESCRIPTION DRUG LABEL	1	0440-0124	CREAM	10 mg	TOPICAL	NDA	17 sections
Silver Sulfadiazine	HUMAN PRESCRIPTION DRUG LABEL	1	33261-589	CREAM	10 mg	TOPICAL	NDA	16 sections
Silver Sulfadiazine	HUMAN PRESCRIPTION DRUG LABEL	1	45865-642	CREAM	10 mg	TOPICAL	NDA	17 sections
Silver Sulfadiazine	HUMAN PRESCRIPTION DRUG LABEL	1	49999-185	CREAM	10 g	TOPICAL	ANDA	19 sections
Silver Sulfadiazine	HUMAN PRESCRIPTION DRUG LABEL	1	50090-0607	CREAM	10 mg	TOPICAL	NDA	17 sections

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