sulfadiazine silver Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-infectives, sulfonamides 4142 22199-08-2

Description:

MoleculeDescription

Synonyms:

  • sulfadiazine silver
  • silvadene
  • silver sulfadiazine
  • sulfadiazine, silver
Antibacterial used topically in burn therapy.
  • Molecular weight: 357.14
  • Formula: C10H9AgN4O2S
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Nov. 26, 1973 FDA KING PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 254.26 18.18 155 2319 265087 53081505
PRIDE syndrome 29.48 18.18 4 2470 16 53346576
Skin ulcer 26.47 18.18 18 2456 36101 53310491
Oral lichen planus 21.42 18.18 5 2469 545 53346047
Cellulitis 20.07 18.18 21 2453 75968 53270624

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 83.45 24.11 46 1278 73354 32438848
Toxic epidermal necrolysis 82.10 24.11 31 1293 20562 32491640
Skin graft failure 28.20 24.11 5 1319 156 32512046

Pharmacologic Action:

SourceCodeDescription
ATC D06BA01 DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
CHEMOTHERAPEUTICS FOR TOPICAL USE
Sulfonamides
ATC D06BA51 DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
CHEMOTHERAPEUTICS FOR TOPICAL USE
Sulfonamides
FDA CS M0020790 Sulfonamides
FDA EPC N0000175503 Sulfonamide Antibacterial
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
CHEBI has role CHEBI:33281 antibiotics
CHEBI has role CHEBI:36047 antibacterial drugs

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Skin ulcer indication 46742003
Burn Wound Infections indication
Minor Bacterial Skin Infections indication
Leukopenia contraindication 84828003 DOID:615
Kidney disease contraindication 90708001 DOID:557
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Superimposed infection contraindication 193198003
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Porphyria contraindication 418470004

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Aurora kinase A Kinase IC50 4.68 CHEMBL
Dihydropteroate synthase Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
4018504 VUID
N0000146826 NUI
D00433 KEGG_DRUG
4018504 VANDF
C0037134 UMLSCUI
CHEBI:9142 CHEBI
CHEMBL1382627 ChEMBL_ID
441244 PUBCHEM_CID
DB05245 DRUGBANK_ID
CHEMBL439 ChEMBL_ID
W46JY43EJR UNII
224926 RXNORM
1640 MMSL
1649 MMSL
5463 MMSL
003135 NDDF
19630009 SNOMEDCT_US
387112002 SNOMEDCT_US
D012837 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 0440-0124 CREAM 10 mg TOPICAL NDA 17 sections
SSD HUMAN PRESCRIPTION DRUG LABEL 1 16590-206 CREAM 10 g TOPICAL NDA 14 sections
ThermazeneSilver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 21695-182 CREAM 10 mg TOPICAL NDA 11 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 33261-589 CREAM 10 mg TOPICAL NDA 16 sections
Silver Sulfadiazene HUMAN PRESCRIPTION DRUG LABEL 1 42254-118 CREAM 10 g TOPICAL NDA 16 sections
SSD Cream HUMAN PRESCRIPTION DRUG LABEL 1 43598-210 CREAM 10 g TOPICAL NDA 11 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 45865-642 CREAM 10 mg TOPICAL NDA 17 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 49999-185 CREAM 10 g TOPICAL ANDA 19 sections
SILVADENE HUMAN PRESCRIPTION DRUG LABEL 1 50090-0230 CREAM 10 mg TOPICAL NDA 19 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 50090-0607 CREAM 10 mg TOPICAL NDA 17 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 50090-0717 CREAM 10 mg TOPICAL NDA 17 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 50090-0763 CREAM 10 mg TOPICAL NDA 17 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 50090-2152 CREAM 10 mg TOPICAL NDA 17 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 50436-1240 CREAM 10 mg TOPICAL NDA 17 sections
Silver Sulfadiazene HUMAN PRESCRIPTION DRUG LABEL 1 50436-3099 CREAM 10 g TOPICAL NDA 16 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 52959-635 CREAM 10 g TOPICAL NDA 14 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 53002-9090 CREAM 10 mg TOPICAL NDA 17 sections
Thermazene HUMAN PRESCRIPTION DRUG LABEL 1 53097-101 CREAM 10 mg TOPICAL NDA 17 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 54868-0375 CREAM 10 mg TOPICAL NDA 14 sections
SSD Cream HUMAN PRESCRIPTION DRUG LABEL 1 55700-640 CREAM 10 g TOPICAL NDA 11 sections
SILVER SULFADIAZINE HUMAN PRESCRIPTION DRUG LABEL 1 59762-0131 CREAM 10 mg TOPICAL NDA AUTHORIZED GENERIC 21 sections
SILVADENE HUMAN PRESCRIPTION DRUG LABEL 1 61570-131 CREAM 10 mg TOPICAL NDA 19 sections
SILVER SULFADIAZINE HUMAN PRESCRIPTION DRUG LABEL 1 61919-206 CREAM 10 mg TOPICAL NDA 12 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 61919-237 CREAM 10 g TOPICAL NDA 11 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 63187-023 CREAM 10 mg TOPICAL NDA 17 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 63629-8768 CREAM 10 mg TOPICAL NDA 16 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 63629-8769 CREAM 10 mg TOPICAL NDA 16 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 63629-8770 CREAM 10 mg TOPICAL NDA 16 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 63629-8771 CREAM 10 mg TOPICAL NDA 16 sections
Silver Sulfadiazine HUMAN PRESCRIPTION DRUG LABEL 1 63629-8772 CREAM 10 mg TOPICAL NDA 16 sections