All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

pyridoxal 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4134	65-22-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: pyridoxal pyridoxaldehyde	The 4-carboxyaldehyde form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Molecular weight: 167.16 Formula: C8H9NO3 CLOGP: 1.18 LIPINSKI: 0 HAC: 4 HDO: 2 TPSA: 70.42 ALOGS: -1.16 ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hepatic function abnormal	68.17	43.81	21	511	37121	63451369
Osteonecrosis of jaw	44.47	43.81	15	517	35108	63453382

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Interstitial lung disease	59.04	41.18	24	405	65258	34891244
Hepatic function abnormal	42.37	41.18	17	412	44346	34912156

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hepatic function abnormal	91.90	32.95	36	1140	73071	79670141
Interstitial lung disease	86.36	32.95	39	1137	112561	79630651
Palmar-plantar erythrodysaesthesia syndrome	58.64	32.95	21	1155	33113	79710099
Osteonecrosis of jaw	39.57	32.95	17	1159	43209	79700003
Platelet count decreased	38.92	32.95	28	1148	194636	79548576

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D018977	Micronutrients
MeSH PA	D014803	Vitamin B Complex
MeSH PA	D014815	Vitamins
CHEBI has role	CHEBI:23357	cofactor
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:75772	S. cerevisiae metabolites
CHEBI has role	CHEBI:76971	Escherichia coli metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.59	acidic
pKa2	12.8	acidic
pKa3	4.21	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Aldehyde oxidase	Enzyme	Q06278	AOXA_HUMAN		Ki	4.52		CHEMBL

External reference:

ID	Source
3THM379K8A	UNII
N0000008146	NUI
C0034263	UMLSCUI
CHEBI:17310	CHEBI
PXL	PDB_CHEM_ID
CHEMBL102970	ChEMBL_ID
1050	PUBCHEM_CID
DB00147	DRUGBANK_ID
D011730	MESH_DESCRIPTOR_UI
9002	RXNORM
019440	NDDF
430926008	SNOMEDCT_US
770955002	SNOMEDCT_US
66-72-8	SECONDARY_CAS_RN

Pharmaceutical products:

None