icodextrin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4105 337376-15-5

Description:

MoleculeDescription

Synonyms:

  • icodextrin
  • extraneal
A glucan that is structurally related to maltodextrin, with more than 85% of its molecules having molecular weights between 1640 and 45 000 Daltons (Da), and a weight-average molecular weight of about 20 000 Da; it is used in dialysis fluids as an alternative to glucose-based solutions, and to reduce adhesions after gynecological or abdominal surgery. It has also been used as a vehicle for drugs given via the peritoneal cavity.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 20, 2002 FDA BAXTER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 924.75 38.00 427 2972 373954 63111669
Peritonitis bacterial 661.36 38.00 127 3272 4752 63480871
Peritonitis 448.18 38.00 116 3283 17038 63468585
Peritoneal dialysis complication 398.26 38.00 67 3332 1153 63484470
Fungal peritonitis 272.29 38.00 43 3356 486 63485137
Device interaction 189.29 38.00 28 3371 196 63485427
Sepsis 188.00 38.00 111 3288 153012 63332611
Encapsulating peritoneal sclerosis 126.54 38.00 21 3378 329 63485294
Ultrafiltration failure 107.27 38.00 17 3382 196 63485427
Cerebrovascular accident 77.30 38.00 56 3343 107968 63377655
Peritoneal cloudy effluent 76.23 38.00 12 3387 132 63485491
Myocardial infarction 74.24 38.00 53 3346 99840 63385783
Cardiac disorder 67.76 38.00 39 3360 50777 63434846
Cardiovascular disorder 67.65 38.00 25 3374 11787 63473836
Hypervolaemia 67.14 38.00 32 3367 28381 63457242
Cardiac arrest 66.23 38.00 48 3351 92497 63393126
Cardiac failure 60.98 38.00 45 3354 89097 63396526
Gangrene 50.49 38.00 17 3382 6106 63479517
Hypoglycaemia 49.54 38.00 34 3365 60031 63425592
Bloody peritoneal effluent 46.26 38.00 7 3392 58 63485565
Marasmus 42.96 38.00 9 3390 516 63485107

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 919.37 41.57 587 3991 397462 34554891
Peritonitis bacterial 915.02 41.57 201 4377 5909 34946444
Peritonitis 556.78 41.57 165 4413 16200 34936153
Peritoneal dialysis complication 505.41 41.57 99 4479 1610 34950743
Fungal peritonitis 361.41 41.57 66 4512 717 34951636
Device interaction 149.43 41.57 30 4548 552 34951801
Encapsulating peritoneal sclerosis 143.12 41.57 29 4549 560 34951793
Myocardial infarction 139.92 41.57 120 4458 120965 34831388
Ultrafiltration failure 130.71 41.57 22 4556 141 34952212
Cardiac disorder 130.37 41.57 77 4501 43049 34909304
Cardiac failure 116.76 41.57 96 4482 91152 34861201
Gangrene 103.95 41.57 34 4544 4552 34947801
Peritoneal cloudy effluent 102.26 41.57 18 4560 155 34952198
Sepsis 95.60 41.57 113 4465 166448 34785905
Hypervolaemia 92.19 41.57 47 4531 19662 34932691
Noninfectious peritonitis 86.42 41.57 15 4563 118 34952235
Cardiac arrest 82.87 41.57 81 4497 96078 34856275
Cardiovascular disorder 68.33 41.57 31 4547 10025 34942328
Catheter site infection 65.97 41.57 21 4557 2576 34949777
Bloody peritoneal effluent 55.18 41.57 10 4568 103 34952250
Drug ineffective 48.19 41.57 3 4575 456748 34495605
Off label use 43.52 41.57 3 4575 419521 34532832

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Peritonitis bacterial 1290.37 35.65 253 4613 9314 79730208
Peritonitis 653.73 35.65 178 4688 27858 79711664
Death 615.56 35.65 395 4471 566119 79173403
Peritoneal dialysis complication 555.74 35.65 100 4766 2254 79737268
Fungal peritonitis 403.16 35.65 68 4798 1032 79738490
Device interaction 272.26 35.65 46 4820 704 79738818
Encapsulating peritoneal sclerosis 219.45 35.65 39 4827 812 79738710
Sepsis 140.12 35.65 122 4744 269306 79470216
Ultrafiltration failure 129.85 35.65 21 4845 241 79739281
Peritoneal cloudy effluent 124.45 35.65 21 4845 318 79739204
Cardiac arrest 114.50 35.65 90 4776 172006 79567516
Gangrene 107.07 35.65 34 4832 8930 79730592
Myocardial infarction 102.90 35.65 87 4779 184042 79555480
Cardiac disorder 82.90 35.65 51 4815 65706 79673816
Noninfectious peritonitis 81.16 35.65 14 4852 243 79739279
Hypervolaemia 77.54 35.65 42 4824 42648 79696874
Cardiac failure 70.12 35.65 65 4801 154777 79584745
Bloody peritoneal effluent 65.03 35.65 11 4855 169 79739353
Hypoglycaemia 62.88 35.65 51 4815 101543 79637979
Blood glucose false positive 62.56 35.65 9 4857 43 79739479
Catheter site infection 57.98 35.65 20 4846 6775 79732747
Complication associated with device 54.96 35.65 25 4841 17471 79722051
Cerebrovascular accident 51.41 35.65 55 4811 155237 79584285
Drug ineffective 48.45 35.65 5 4861 1080908 78658614
Peritoneal effluent abnormal 40.42 35.65 6 4860 37 79739485
Peritoneal disorder 38.77 35.65 9 4857 726 79738796

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D015314 Dialysis Solutions
MeSH PA D019999 Pharmaceutical Solutions

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4021369 VUID
N0000148788 NUI
D03266 KEGG_DRUG
4021369 VANDF
C0538727 UMLSCUI
CHEMBL1201472 ChEMBL_ID
D000077607 MESH_DESCRIPTOR_UI
DB00702 DRUGBANK_ID
7048 INN_ID
2NX48Z0A9G UNII
3517 PUBCHEM_CID
1100743 RXNORM
19728 MMSL
59958 MMSL
006146 NDDF
412135003 SNOMEDCT_US
417226008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
EXTRANEAL HUMAN PRESCRIPTION DRUG LABEL 5 0941-0679 INJECTION, SOLUTION 7.50 g INTRAPERITONEAL NDA 25 sections
EXTRANEAL HUMAN PRESCRIPTION DRUG LABEL 5 0941-0679 INJECTION, SOLUTION 7.50 g INTRAPERITONEAL NDA 25 sections