icodextrin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4105 337376-15-5

Description:

MoleculeDescription

Synonyms:

  • icodextrin
  • extraneal
A glucan that is structurally related to maltodextrin, with more than 85% of its molecules having molecular weights between 1640 and 45 000 Daltons (Da), and a weight-average molecular weight of about 20 000 Da; it is used in dialysis fluids as an alternative to glucose-based solutions, and to reduce adhesions after gynecological or abdominal surgery. It has also been used as a vehicle for drugs given via the peritoneal cavity.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 20, 2002 FDA BAXTER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 893.12 37.60 427 2943 324952 50276802
Peritonitis bacterial 627.42 37.60 125 3245 4536 50597218
Peritonitis 430.11 37.60 115 3255 15371 50586383
Peritoneal dialysis complication 385.83 37.60 67 3303 1114 50600640
Fungal peritonitis 244.16 37.60 40 3330 457 50601297
Device interaction 183.56 37.60 28 3342 193 50601561
Sepsis 180.13 37.60 111 3259 132814 50468940
Encapsulating peritoneal sclerosis 122.69 37.60 21 3349 317 50601437
Ultrafiltration failure 97.35 37.60 16 3354 186 50601568
Peritoneal cloudy effluent 71.94 37.60 11 3359 77 50601677
Myocardial infarction 67.16 37.60 52 3318 88975 50512779
Cardiac disorder 65.92 37.60 39 3331 42940 50558814
Cardiovascular disorder 65.31 37.60 25 3345 10429 50591325
Hypervolaemia 63.79 37.60 32 3338 25467 50576287
Cardiac arrest 61.22 37.60 48 3322 83603 50518151
Cardiac failure 58.61 37.60 45 3325 75995 50525759
Cerebrovascular accident 51.96 37.60 46 3324 94634 50507120
Gangrene 51.29 37.60 17 3353 4675 50597079
Hypoglycaemia 46.35 37.60 34 3336 53547 50548207
Bloody peritoneal effluent 45.90 37.60 7 3363 48 50601706
Marasmus 42.59 37.60 9 3361 431 50601323

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 911.25 40.08 586 3969 341498 29228474
Peritonitis bacterial 867.25 40.08 196 4359 5560 29564412
Peritonitis 542.18 40.08 164 4391 14660 29555312
Peritoneal dialysis complication 496.10 40.08 99 4456 1498 29568474
Fungal peritonitis 352.43 40.08 65 4490 627 29569345
Device interaction 146.00 40.08 30 4525 525 29569447
Encapsulating peritoneal sclerosis 138.83 40.08 29 4526 552 29569420
Myocardial infarction 128.83 40.08 118 4437 110178 29459794
Cardiac disorder 124.03 40.08 75 4480 37188 29532784
Ultrafiltration failure 120.78 40.08 21 4534 139 29569833
Cardiac failure 114.94 40.08 96 4459 79191 29490781
Peritoneal cloudy effluent 103.67 40.08 18 4537 118 29569854
Gangrene 101.33 40.08 34 4521 4184 29565788
Sepsis 93.28 40.08 112 4443 142570 29427402
Hypervolaemia 87.30 40.08 46 4509 17499 29552473
Noninfectious peritonitis 84.56 40.08 15 4540 113 29569859
Cardiac arrest 79.75 40.08 81 4474 85510 29484462
Cardiovascular disorder 67.03 40.08 31 4524 8904 29561068
Catheter site infection 63.50 40.08 20 4535 2012 29567960
Bloody peritoneal effluent 54.39 40.08 10 4545 94 29569878
Drug ineffective 44.47 40.08 3 4552 363167 29206805
Peritoneal effluent abnormal 40.84 40.08 7 4548 42 29569930

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Peritonitis bacterial 1211.38 36.75 246 4581 8797 64485108
Peritonitis 628.64 36.75 176 4651 24847 64469058
Death 599.72 36.75 395 4432 482310 64011595
Peritoneal dialysis complication 540.86 36.75 100 4727 2128 64491777
Fungal peritonitis 370.47 36.75 64 4763 907 64492998
Device interaction 266.18 36.75 46 4781 652 64493253
Encapsulating peritoneal sclerosis 212.71 36.75 39 4788 786 64493119
Sepsis 133.15 36.75 121 4706 230220 64263685
Peritoneal cloudy effluent 128.95 36.75 21 4806 202 64493703
Ultrafiltration failure 119.63 36.75 20 4807 229 64493676
Cardiac arrest 107.11 36.75 90 4737 153974 64339931
Gangrene 106.94 36.75 34 4793 7304 64486601
Myocardial infarction 93.46 36.75 86 4741 165735 64328170
Cardiac disorder 81.02 36.75 51 4776 55765 64438140
Noninfectious peritonitis 78.74 36.75 14 4813 235 64493670
Hypervolaemia 71.12 36.75 41 4786 38244 64455661
Cardiac failure 67.50 36.75 65 4762 132308 64361597
Bloody peritoneal effluent 63.48 36.75 11 4816 158 64493747
Blood glucose false positive 60.73 36.75 9 4818 43 64493862
Hypoglycaemia 59.24 36.75 51 4776 89841 64404064
Complication associated with device 53.64 36.75 25 4802 15055 64478850
Catheter site infection 53.62 36.75 19 4808 5674 64488231
Drug ineffective 45.57 36.75 5 4822 840242 63653663
Peritoneal effluent abnormal 39.63 36.75 6 4821 34 64493871
Peritoneal disorder 38.06 36.75 9 4818 640 64493265

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D015314 Dialysis Solutions
MeSH PA D019999 Pharmaceutical Solutions

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4021369 VUID
N0000148788 NUI
D03266 KEGG_DRUG
4021369 VANDF
C0538727 UMLSCUI
CHEMBL1201472 ChEMBL_ID
D000077607 MESH_DESCRIPTOR_UI
DB00702 DRUGBANK_ID
7048 INN_ID
2NX48Z0A9G UNII
1100743 RXNORM
19728 MMSL
59958 MMSL
006146 NDDF
412135003 SNOMEDCT_US
417226008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
EXTRANEAL HUMAN PRESCRIPTION DRUG LABEL 5 0941-0679 INJECTION, SOLUTION 7.50 g INTRAPERITONEAL NDA 25 sections