icodextrin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4105	337376-15-5

Description:

Molecule	Description
Synonyms: icodextrin extraneal	A glucan that is structurally related to maltodextrin, with more than 85% of its molecules having molecular weights between 1640 and 45 000 Daltons (Da), and a weight-average molecular weight of about 20 000 Da; it is used in dialysis fluids as an alternative to glucose-based solutions, and to reduce adhesions after gynecological or abdominal surgery. It has also been used as a vehicle for drugs given via the peritoneal cavity. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

icodextrin
extraneal

A glucan that is structurally related to maltodextrin, with more than 85% of its molecules having molecular weights between 1640 and 45 000 Daltons (Da), and a weight-average molecular weight of about 20 000 Da; it is used in dialysis fluids as an alternative to glucose-based solutions, and to reduce adhesions after gynecological or abdominal surgery. It has also been used as a vehicle for drugs given via the peritoneal cavity.

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 20, 2002	FDA	BAXTER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Death	924.75	38.00	427	2972	373954	63111669
Peritonitis bacterial	661.36	38.00	127	3272	4752	63480871
Peritonitis	448.18	38.00	116	3283	17038	63468585
Peritoneal dialysis complication	398.26	38.00	67	3332	1153	63484470
Fungal peritonitis	272.29	38.00	43	3356	486	63485137
Device interaction	189.29	38.00	28	3371	196	63485427
Sepsis	188.00	38.00	111	3288	153012	63332611
Encapsulating peritoneal sclerosis	126.54	38.00	21	3378	329	63485294
Ultrafiltration failure	107.27	38.00	17	3382	196	63485427
Cerebrovascular accident	77.30	38.00	56	3343	107968	63377655
Peritoneal cloudy effluent	76.23	38.00	12	3387	132	63485491
Myocardial infarction	74.24	38.00	53	3346	99840	63385783
Cardiac disorder	67.76	38.00	39	3360	50777	63434846
Cardiovascular disorder	67.65	38.00	25	3374	11787	63473836
Hypervolaemia	67.14	38.00	32	3367	28381	63457242
Cardiac arrest	66.23	38.00	48	3351	92497	63393126
Cardiac failure	60.98	38.00	45	3354	89097	63396526
Gangrene	50.49	38.00	17	3382	6106	63479517
Hypoglycaemia	49.54	38.00	34	3365	60031	63425592
Bloody peritoneal effluent	46.26	38.00	7	3392	58	63485565
Marasmus	42.96	38.00	9	3390	516	63485107

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Death	919.37	41.57	587	3991	397462	34554891
Peritonitis bacterial	915.02	41.57	201	4377	5909	34946444
Peritonitis	556.78	41.57	165	4413	16200	34936153
Peritoneal dialysis complication	505.41	41.57	99	4479	1610	34950743
Fungal peritonitis	361.41	41.57	66	4512	717	34951636
Device interaction	149.43	41.57	30	4548	552	34951801
Encapsulating peritoneal sclerosis	143.12	41.57	29	4549	560	34951793
Myocardial infarction	139.92	41.57	120	4458	120965	34831388
Ultrafiltration failure	130.71	41.57	22	4556	141	34952212
Cardiac disorder	130.37	41.57	77	4501	43049	34909304
Cardiac failure	116.76	41.57	96	4482	91152	34861201
Gangrene	103.95	41.57	34	4544	4552	34947801
Peritoneal cloudy effluent	102.26	41.57	18	4560	155	34952198
Sepsis	95.60	41.57	113	4465	166448	34785905
Hypervolaemia	92.19	41.57	47	4531	19662	34932691
Noninfectious peritonitis	86.42	41.57	15	4563	118	34952235
Cardiac arrest	82.87	41.57	81	4497	96078	34856275
Cardiovascular disorder	68.33	41.57	31	4547	10025	34942328
Catheter site infection	65.97	41.57	21	4557	2576	34949777
Bloody peritoneal effluent	55.18	41.57	10	4568	103	34952250
Drug ineffective	48.19	41.57	3	4575	456748	34495605
Off label use	43.52	41.57	3	4575	419521	34532832

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Peritonitis bacterial	1290.37	35.65	253	4613	9314	79730208
Peritonitis	653.73	35.65	178	4688	27858	79711664
Death	615.56	35.65	395	4471	566119	79173403
Peritoneal dialysis complication	555.74	35.65	100	4766	2254	79737268
Fungal peritonitis	403.16	35.65	68	4798	1032	79738490
Device interaction	272.26	35.65	46	4820	704	79738818
Encapsulating peritoneal sclerosis	219.45	35.65	39	4827	812	79738710
Sepsis	140.12	35.65	122	4744	269306	79470216
Ultrafiltration failure	129.85	35.65	21	4845	241	79739281
Peritoneal cloudy effluent	124.45	35.65	21	4845	318	79739204
Cardiac arrest	114.50	35.65	90	4776	172006	79567516
Gangrene	107.07	35.65	34	4832	8930	79730592
Myocardial infarction	102.90	35.65	87	4779	184042	79555480
Cardiac disorder	82.90	35.65	51	4815	65706	79673816
Noninfectious peritonitis	81.16	35.65	14	4852	243	79739279
Hypervolaemia	77.54	35.65	42	4824	42648	79696874
Cardiac failure	70.12	35.65	65	4801	154777	79584745
Bloody peritoneal effluent	65.03	35.65	11	4855	169	79739353
Hypoglycaemia	62.88	35.65	51	4815	101543	79637979
Blood glucose false positive	62.56	35.65	9	4857	43	79739479
Catheter site infection	57.98	35.65	20	4846	6775	79732747
Complication associated with device	54.96	35.65	25	4841	17471	79722051
Cerebrovascular accident	51.41	35.65	55	4811	155237	79584285
Drug ineffective	48.45	35.65	5	4861	1080908	78658614
Peritoneal effluent abnormal	40.42	35.65	6	4860	37	79739485
Peritoneal disorder	38.77	35.65	9	4857	726	79738796

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D015314	Dialysis Solutions
MeSH PA	D019999	Pharmaceutical Solutions

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4021369	VUID
N0000148788	NUI
D03266	KEGG_DRUG
4021369	VANDF
C0538727	UMLSCUI
CHEMBL1201472	ChEMBL_ID
D000077607	MESH_DESCRIPTOR_UI
DB00702	DRUGBANK_ID
7048	INN_ID
2NX48Z0A9G	UNII
3517	PUBCHEM_CID
1100743	RXNORM
19728	MMSL
59958	MMSL
006146	NDDF
412135003	SNOMEDCT_US
417226008	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
EXTRANEAL	HUMAN PRESCRIPTION DRUG LABEL	5	0941-0679	INJECTION, SOLUTION	7.50 g	INTRAPERITONEAL	NDA	25 sections
EXTRANEAL	HUMAN PRESCRIPTION DRUG LABEL	5	0941-0679	INJECTION, SOLUTION	7.50 g	INTRAPERITONEAL	NDA	25 sections