icodextrin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4105 337376-15-5

Description:

MoleculeDescription

Synonyms:

  • icodextrin
  • extraneal
A glucan that is structurally related to maltodextrin, with more than 85% of its molecules having molecular weights between 1640 and 45 000 Daltons (Da), and a weight-average molecular weight of about 20 000 Da; it is used in dialysis fluids as an alternative to glucose-based solutions, and to reduce adhesions after gynecological or abdominal surgery. It has also been used as a vehicle for drugs given via the peritoneal cavity.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 20, 2002 FDA BAXTER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 3301.62 35.57 1319 5449 355913 52986385
Peritonitis bacterial 785.42 35.57 192 6576 9313 53332985
Peritonitis 723.82 35.57 214 6554 21473 53320825
Peritoneal dialysis complication 613.84 35.57 126 6642 2707 53339591
Fungal peritonitis 247.57 35.57 49 6719 865 53341433
Sepsis 204.59 35.57 160 6608 146269 53196029
Ultrafiltration failure 200.74 35.57 39 6729 622 53341676
Device interaction 182.78 35.57 31 6737 217 53342081
Encapsulating peritoneal sclerosis 173.55 35.57 32 6736 379 53341919
Peritoneal cloudy effluent 150.51 35.57 27 6741 271 53342027
Fluid overload 136.98 35.57 68 6700 27763 53314535
Cardiac disorder 118.73 35.57 74 6694 46892 53295406
Myocardial infarction 90.23 35.57 85 6683 99269 53243029
Cardiac arrest 88.64 35.57 82 6686 93585 53248713
Cardiovascular disorder 81.47 35.57 37 6731 12376 53329922
Cardiac failure 75.16 35.57 72 6696 85772 53256526
Cerebrovascular accident 71.61 35.57 77 6691 105097 53237201
Drug ineffective 70.95 35.57 10 6758 817235 52525063
Catheter site infection 63.91 35.57 24 6744 4968 53337330
Gangrene 60.82 35.57 23 6745 4854 53337444
Marasmus 60.26 35.57 14 6754 538 53341760
Hypotension 57.71 35.57 110 6658 253966 53088332
Bloody peritoneal effluent 56.40 35.57 13 6755 482 53341816
Noninfectious peritonitis 47.65 35.57 10 6758 238 53342060
Fatigue 42.40 35.57 20 6748 730486 52611812
Exfoliative rash 41.50 35.57 15 6753 2789 53339509
Multimorbidity 41.46 35.57 11 6757 732 53341566
Diabetic foot 40.38 35.57 13 6755 1705 53340593
Hypoglycaemia 39.75 35.57 43 6725 58970 53283328
Procedural pain 39.19 35.57 24 6744 14693 53327605
Skin exfoliation 38.82 35.57 34 6734 36049 53306249
Abdominal distension 38.51 35.57 49 6719 79741 53262557
Disease complication 35.78 35.57 14 6754 3236 53339062

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 3539.32 36.84 1820 7662 380697 32123347
Peritonitis bacterial 1216.43 36.84 341 9141 12155 32491889
Peritoneal dialysis complication 1005.98 36.84 236 9246 4032 32500012
Peritonitis 848.57 36.84 297 9185 22033 32482011
Fungal peritonitis 394.16 36.84 90 9392 1346 32502698
Fluid overload 236.42 36.84 115 9367 19506 32484538
Cardiac disorder 214.60 36.84 140 9342 41726 32462318
Peritoneal cloudy effluent 200.41 36.84 42 9440 409 32503635
Ultrafiltration failure 194.25 36.84 45 9437 718 32503326
Cardiac failure 153.95 36.84 160 9322 91513 32412531
Encapsulating peritoneal sclerosis 146.28 36.84 35 9447 646 32503398
Myocardial infarction 145.83 36.84 181 9301 125495 32378549
Catheter site infection 141.11 36.84 46 9436 2708 32501336
Cardiac arrest 132.97 36.84 152 9330 96624 32407420
Sepsis 132.79 36.84 195 9287 158639 32345405
Device interaction 130.92 36.84 31 9451 546 32503498
Gangrene 105.06 36.84 43 9439 4839 32499205
Noninfectious peritonitis 98.27 36.84 21 9461 226 32503818
Cardiovascular disorder 83.44 36.84 47 9435 10715 32493329
Drug ineffective 83.31 36.84 8 9474 383469 32120575
Bloody peritoneal effluent 75.92 36.84 20 9462 552 32503492
Skin exfoliation 73.57 36.84 60 9422 25097 32478947
Off label use 73.30 36.84 4 9478 306316 32197728
Procedural pain 68.86 36.84 33 9449 5396 32498648
Multimorbidity 66.35 36.84 18 9464 557 32503487
Peritoneal disorder 61.91 36.84 16 9466 409 32503635
Localised infection 61.54 36.84 44 9438 15143 32488901
Peritoneal effluent abnormal 60.41 36.84 13 9469 145 32503899
Fatigue 56.99 36.84 16 9466 350685 32153359
Marasmus 46.67 36.84 14 9468 625 32503419
Hernia 46.63 36.84 31 9451 9484 32494560
Cerebrovascular accident 46.27 36.84 87 9395 86233 32417811
Diabetic complication 41.47 36.84 14 9468 918 32503126
Diabetic foot 40.83 36.84 19 9463 2907 32501137

Pharmacologic Action:

SourceCodeDescription
MeSH PA D015314 Dialysis Solutions
MeSH PA D019999 Pharmaceutical Solutions

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4021369 VUID
N0000148788 NUI
D03266 KEGG_DRUG
4021369 VANDF
C0538727 UMLSCUI
CHEMBL1201472 ChEMBL_ID
D000077607 MESH_DESCRIPTOR_UI
DB00702 DRUGBANK_ID
7048 INN_ID
2NX48Z0A9G UNII
1100743 RXNORM
19728 MMSL
59958 MMSL
006146 NDDF
412135003 SNOMEDCT_US
417226008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
EXTRANEAL HUMAN PRESCRIPTION DRUG LABEL 5 0941-0679 INJECTION, SOLUTION 7.50 g INTRAPERITONEAL NDA 25 sections