icodextrin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4105	337376-15-5

Description:

Molecule	Description
Synonyms: icodextrin extraneal	A glucan that is structurally related to maltodextrin, with more than 85% of its molecules having molecular weights between 1640 and 45 000 Daltons (Da), and a weight-average molecular weight of about 20 000 Da; it is used in dialysis fluids as an alternative to glucose-based solutions, and to reduce adhesions after gynecological or abdominal surgery. It has also been used as a vehicle for drugs given via the peritoneal cavity. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

icodextrin
extraneal

A glucan that is structurally related to maltodextrin, with more than 85% of its molecules having molecular weights between 1640 and 45 000 Daltons (Da), and a weight-average molecular weight of about 20 000 Da; it is used in dialysis fluids as an alternative to glucose-based solutions, and to reduce adhesions after gynecological or abdominal surgery. It has also been used as a vehicle for drugs given via the peritoneal cavity.

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 20, 2002	FDA	BAXTER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Death	893.12	37.60	427	2943	324952	50276802
Peritonitis bacterial	627.42	37.60	125	3245	4536	50597218
Peritonitis	430.11	37.60	115	3255	15371	50586383
Peritoneal dialysis complication	385.83	37.60	67	3303	1114	50600640
Fungal peritonitis	244.16	37.60	40	3330	457	50601297
Device interaction	183.56	37.60	28	3342	193	50601561
Sepsis	180.13	37.60	111	3259	132814	50468940
Encapsulating peritoneal sclerosis	122.69	37.60	21	3349	317	50601437
Ultrafiltration failure	97.35	37.60	16	3354	186	50601568
Peritoneal cloudy effluent	71.94	37.60	11	3359	77	50601677
Myocardial infarction	67.16	37.60	52	3318	88975	50512779
Cardiac disorder	65.92	37.60	39	3331	42940	50558814
Cardiovascular disorder	65.31	37.60	25	3345	10429	50591325
Hypervolaemia	63.79	37.60	32	3338	25467	50576287
Cardiac arrest	61.22	37.60	48	3322	83603	50518151
Cardiac failure	58.61	37.60	45	3325	75995	50525759
Cerebrovascular accident	51.96	37.60	46	3324	94634	50507120
Gangrene	51.29	37.60	17	3353	4675	50597079
Hypoglycaemia	46.35	37.60	34	3336	53547	50548207
Bloody peritoneal effluent	45.90	37.60	7	3363	48	50601706
Marasmus	42.59	37.60	9	3361	431	50601323

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Death	911.25	40.08	586	3969	341498	29228474
Peritonitis bacterial	867.25	40.08	196	4359	5560	29564412
Peritonitis	542.18	40.08	164	4391	14660	29555312
Peritoneal dialysis complication	496.10	40.08	99	4456	1498	29568474
Fungal peritonitis	352.43	40.08	65	4490	627	29569345
Device interaction	146.00	40.08	30	4525	525	29569447
Encapsulating peritoneal sclerosis	138.83	40.08	29	4526	552	29569420
Myocardial infarction	128.83	40.08	118	4437	110178	29459794
Cardiac disorder	124.03	40.08	75	4480	37188	29532784
Ultrafiltration failure	120.78	40.08	21	4534	139	29569833
Cardiac failure	114.94	40.08	96	4459	79191	29490781
Peritoneal cloudy effluent	103.67	40.08	18	4537	118	29569854
Gangrene	101.33	40.08	34	4521	4184	29565788
Sepsis	93.28	40.08	112	4443	142570	29427402
Hypervolaemia	87.30	40.08	46	4509	17499	29552473
Noninfectious peritonitis	84.56	40.08	15	4540	113	29569859
Cardiac arrest	79.75	40.08	81	4474	85510	29484462
Cardiovascular disorder	67.03	40.08	31	4524	8904	29561068
Catheter site infection	63.50	40.08	20	4535	2012	29567960
Bloody peritoneal effluent	54.39	40.08	10	4545	94	29569878
Drug ineffective	44.47	40.08	3	4552	363167	29206805
Peritoneal effluent abnormal	40.84	40.08	7	4548	42	29569930

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Peritonitis bacterial	1211.38	36.75	246	4581	8797	64485108
Peritonitis	628.64	36.75	176	4651	24847	64469058
Death	599.72	36.75	395	4432	482310	64011595
Peritoneal dialysis complication	540.86	36.75	100	4727	2128	64491777
Fungal peritonitis	370.47	36.75	64	4763	907	64492998
Device interaction	266.18	36.75	46	4781	652	64493253
Encapsulating peritoneal sclerosis	212.71	36.75	39	4788	786	64493119
Sepsis	133.15	36.75	121	4706	230220	64263685
Peritoneal cloudy effluent	128.95	36.75	21	4806	202	64493703
Ultrafiltration failure	119.63	36.75	20	4807	229	64493676
Cardiac arrest	107.11	36.75	90	4737	153974	64339931
Gangrene	106.94	36.75	34	4793	7304	64486601
Myocardial infarction	93.46	36.75	86	4741	165735	64328170
Cardiac disorder	81.02	36.75	51	4776	55765	64438140
Noninfectious peritonitis	78.74	36.75	14	4813	235	64493670
Hypervolaemia	71.12	36.75	41	4786	38244	64455661
Cardiac failure	67.50	36.75	65	4762	132308	64361597
Bloody peritoneal effluent	63.48	36.75	11	4816	158	64493747
Blood glucose false positive	60.73	36.75	9	4818	43	64493862
Hypoglycaemia	59.24	36.75	51	4776	89841	64404064
Complication associated with device	53.64	36.75	25	4802	15055	64478850
Catheter site infection	53.62	36.75	19	4808	5674	64488231
Drug ineffective	45.57	36.75	5	4822	840242	63653663
Peritoneal effluent abnormal	39.63	36.75	6	4821	34	64493871
Peritoneal disorder	38.06	36.75	9	4818	640	64493265

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D015314	Dialysis Solutions
MeSH PA	D019999	Pharmaceutical Solutions

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4021369	VUID
N0000148788	NUI
D03266	KEGG_DRUG
4021369	VANDF
C0538727	UMLSCUI
CHEMBL1201472	ChEMBL_ID
D000077607	MESH_DESCRIPTOR_UI
DB00702	DRUGBANK_ID
7048	INN_ID
2NX48Z0A9G	UNII
1100743	RXNORM
19728	MMSL
59958	MMSL
006146	NDDF
412135003	SNOMEDCT_US
417226008	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
EXTRANEAL	HUMAN PRESCRIPTION DRUG LABEL	5	0941-0679	INJECTION, SOLUTION	7.50 g	INTRAPERITONEAL	NDA	25 sections