Stem definition | Drug id | CAS RN |
---|---|---|
4105 | 337376-15-5 |
Molecule | Description |
---|---|
Synonyms:
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A glucan that is structurally related to maltodextrin, with more than 85% of its molecules having molecular weights between 1640 and 45 000 Daltons (Da), and a weight-average molecular weight of about 20 000 Da; it is used in dialysis fluids as an alternative to glucose-based solutions, and to reduce adhesions after gynecological or abdominal surgery. It has also been used as a vehicle for drugs given via the peritoneal cavity.
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Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 20, 2002 | FDA | BAXTER HLTHCARE |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Death | 3301.62 | 35.57 | 1319 | 5449 | 355913 | 52986385 |
Peritonitis bacterial | 785.42 | 35.57 | 192 | 6576 | 9313 | 53332985 |
Peritonitis | 723.82 | 35.57 | 214 | 6554 | 21473 | 53320825 |
Peritoneal dialysis complication | 613.84 | 35.57 | 126 | 6642 | 2707 | 53339591 |
Fungal peritonitis | 247.57 | 35.57 | 49 | 6719 | 865 | 53341433 |
Sepsis | 204.59 | 35.57 | 160 | 6608 | 146269 | 53196029 |
Ultrafiltration failure | 200.74 | 35.57 | 39 | 6729 | 622 | 53341676 |
Device interaction | 182.78 | 35.57 | 31 | 6737 | 217 | 53342081 |
Encapsulating peritoneal sclerosis | 173.55 | 35.57 | 32 | 6736 | 379 | 53341919 |
Peritoneal cloudy effluent | 150.51 | 35.57 | 27 | 6741 | 271 | 53342027 |
Fluid overload | 136.98 | 35.57 | 68 | 6700 | 27763 | 53314535 |
Cardiac disorder | 118.73 | 35.57 | 74 | 6694 | 46892 | 53295406 |
Myocardial infarction | 90.23 | 35.57 | 85 | 6683 | 99269 | 53243029 |
Cardiac arrest | 88.64 | 35.57 | 82 | 6686 | 93585 | 53248713 |
Cardiovascular disorder | 81.47 | 35.57 | 37 | 6731 | 12376 | 53329922 |
Cardiac failure | 75.16 | 35.57 | 72 | 6696 | 85772 | 53256526 |
Cerebrovascular accident | 71.61 | 35.57 | 77 | 6691 | 105097 | 53237201 |
Drug ineffective | 70.95 | 35.57 | 10 | 6758 | 817235 | 52525063 |
Catheter site infection | 63.91 | 35.57 | 24 | 6744 | 4968 | 53337330 |
Gangrene | 60.82 | 35.57 | 23 | 6745 | 4854 | 53337444 |
Marasmus | 60.26 | 35.57 | 14 | 6754 | 538 | 53341760 |
Hypotension | 57.71 | 35.57 | 110 | 6658 | 253966 | 53088332 |
Bloody peritoneal effluent | 56.40 | 35.57 | 13 | 6755 | 482 | 53341816 |
Noninfectious peritonitis | 47.65 | 35.57 | 10 | 6758 | 238 | 53342060 |
Fatigue | 42.40 | 35.57 | 20 | 6748 | 730486 | 52611812 |
Exfoliative rash | 41.50 | 35.57 | 15 | 6753 | 2789 | 53339509 |
Multimorbidity | 41.46 | 35.57 | 11 | 6757 | 732 | 53341566 |
Diabetic foot | 40.38 | 35.57 | 13 | 6755 | 1705 | 53340593 |
Hypoglycaemia | 39.75 | 35.57 | 43 | 6725 | 58970 | 53283328 |
Procedural pain | 39.19 | 35.57 | 24 | 6744 | 14693 | 53327605 |
Skin exfoliation | 38.82 | 35.57 | 34 | 6734 | 36049 | 53306249 |
Abdominal distension | 38.51 | 35.57 | 49 | 6719 | 79741 | 53262557 |
Disease complication | 35.78 | 35.57 | 14 | 6754 | 3236 | 53339062 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Death | 3539.32 | 36.84 | 1820 | 7662 | 380697 | 32123347 |
Peritonitis bacterial | 1216.43 | 36.84 | 341 | 9141 | 12155 | 32491889 |
Peritoneal dialysis complication | 1005.98 | 36.84 | 236 | 9246 | 4032 | 32500012 |
Peritonitis | 848.57 | 36.84 | 297 | 9185 | 22033 | 32482011 |
Fungal peritonitis | 394.16 | 36.84 | 90 | 9392 | 1346 | 32502698 |
Fluid overload | 236.42 | 36.84 | 115 | 9367 | 19506 | 32484538 |
Cardiac disorder | 214.60 | 36.84 | 140 | 9342 | 41726 | 32462318 |
Peritoneal cloudy effluent | 200.41 | 36.84 | 42 | 9440 | 409 | 32503635 |
Ultrafiltration failure | 194.25 | 36.84 | 45 | 9437 | 718 | 32503326 |
Cardiac failure | 153.95 | 36.84 | 160 | 9322 | 91513 | 32412531 |
Encapsulating peritoneal sclerosis | 146.28 | 36.84 | 35 | 9447 | 646 | 32503398 |
Myocardial infarction | 145.83 | 36.84 | 181 | 9301 | 125495 | 32378549 |
Catheter site infection | 141.11 | 36.84 | 46 | 9436 | 2708 | 32501336 |
Cardiac arrest | 132.97 | 36.84 | 152 | 9330 | 96624 | 32407420 |
Sepsis | 132.79 | 36.84 | 195 | 9287 | 158639 | 32345405 |
Device interaction | 130.92 | 36.84 | 31 | 9451 | 546 | 32503498 |
Gangrene | 105.06 | 36.84 | 43 | 9439 | 4839 | 32499205 |
Noninfectious peritonitis | 98.27 | 36.84 | 21 | 9461 | 226 | 32503818 |
Cardiovascular disorder | 83.44 | 36.84 | 47 | 9435 | 10715 | 32493329 |
Drug ineffective | 83.31 | 36.84 | 8 | 9474 | 383469 | 32120575 |
Bloody peritoneal effluent | 75.92 | 36.84 | 20 | 9462 | 552 | 32503492 |
Skin exfoliation | 73.57 | 36.84 | 60 | 9422 | 25097 | 32478947 |
Off label use | 73.30 | 36.84 | 4 | 9478 | 306316 | 32197728 |
Procedural pain | 68.86 | 36.84 | 33 | 9449 | 5396 | 32498648 |
Multimorbidity | 66.35 | 36.84 | 18 | 9464 | 557 | 32503487 |
Peritoneal disorder | 61.91 | 36.84 | 16 | 9466 | 409 | 32503635 |
Localised infection | 61.54 | 36.84 | 44 | 9438 | 15143 | 32488901 |
Peritoneal effluent abnormal | 60.41 | 36.84 | 13 | 9469 | 145 | 32503899 |
Fatigue | 56.99 | 36.84 | 16 | 9466 | 350685 | 32153359 |
Marasmus | 46.67 | 36.84 | 14 | 9468 | 625 | 32503419 |
Hernia | 46.63 | 36.84 | 31 | 9451 | 9484 | 32494560 |
Cerebrovascular accident | 46.27 | 36.84 | 87 | 9395 | 86233 | 32417811 |
Diabetic complication | 41.47 | 36.84 | 14 | 9468 | 918 | 32503126 |
Diabetic foot | 40.83 | 36.84 | 19 | 9463 | 2907 | 32501137 |
Source | Code | Description |
---|---|---|
MeSH PA | D015314 | Dialysis Solutions |
MeSH PA | D019999 | Pharmaceutical Solutions |
None
None
None
None
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ID | Source |
---|---|
4021369 | VUID |
N0000148788 | NUI |
D03266 | KEGG_DRUG |
4021369 | VANDF |
C0538727 | UMLSCUI |
CHEMBL1201472 | ChEMBL_ID |
D000077607 | MESH_DESCRIPTOR_UI |
DB00702 | DRUGBANK_ID |
7048 | INN_ID |
2NX48Z0A9G | UNII |
1100743 | RXNORM |
19728 | MMSL |
59958 | MMSL |
006146 | NDDF |
412135003 | SNOMEDCT_US |
417226008 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
EXTRANEAL | HUMAN PRESCRIPTION DRUG LABEL | 5 | 0941-0679 | INJECTION, SOLUTION | 7.50 g | INTRAPERITONEAL | NDA | 25 sections |