Stem definition | Drug id | CAS RN |
---|---|---|
4105 | 337376-15-5 |
Molecule | Description |
---|---|
Synonyms:
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A glucan that is structurally related to maltodextrin, with more than 85% of its molecules having molecular weights between 1640 and 45 000 Daltons (Da), and a weight-average molecular weight of about 20 000 Da; it is used in dialysis fluids as an alternative to glucose-based solutions, and to reduce adhesions after gynecological or abdominal surgery. It has also been used as a vehicle for drugs given via the peritoneal cavity.
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Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 20, 2002 | FDA | BAXTER HLTHCARE |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Death | 893.12 | 37.60 | 427 | 2943 | 324952 | 50276802 |
Peritonitis bacterial | 627.42 | 37.60 | 125 | 3245 | 4536 | 50597218 |
Peritonitis | 430.11 | 37.60 | 115 | 3255 | 15371 | 50586383 |
Peritoneal dialysis complication | 385.83 | 37.60 | 67 | 3303 | 1114 | 50600640 |
Fungal peritonitis | 244.16 | 37.60 | 40 | 3330 | 457 | 50601297 |
Device interaction | 183.56 | 37.60 | 28 | 3342 | 193 | 50601561 |
Sepsis | 180.13 | 37.60 | 111 | 3259 | 132814 | 50468940 |
Encapsulating peritoneal sclerosis | 122.69 | 37.60 | 21 | 3349 | 317 | 50601437 |
Ultrafiltration failure | 97.35 | 37.60 | 16 | 3354 | 186 | 50601568 |
Peritoneal cloudy effluent | 71.94 | 37.60 | 11 | 3359 | 77 | 50601677 |
Myocardial infarction | 67.16 | 37.60 | 52 | 3318 | 88975 | 50512779 |
Cardiac disorder | 65.92 | 37.60 | 39 | 3331 | 42940 | 50558814 |
Cardiovascular disorder | 65.31 | 37.60 | 25 | 3345 | 10429 | 50591325 |
Hypervolaemia | 63.79 | 37.60 | 32 | 3338 | 25467 | 50576287 |
Cardiac arrest | 61.22 | 37.60 | 48 | 3322 | 83603 | 50518151 |
Cardiac failure | 58.61 | 37.60 | 45 | 3325 | 75995 | 50525759 |
Cerebrovascular accident | 51.96 | 37.60 | 46 | 3324 | 94634 | 50507120 |
Gangrene | 51.29 | 37.60 | 17 | 3353 | 4675 | 50597079 |
Hypoglycaemia | 46.35 | 37.60 | 34 | 3336 | 53547 | 50548207 |
Bloody peritoneal effluent | 45.90 | 37.60 | 7 | 3363 | 48 | 50601706 |
Marasmus | 42.59 | 37.60 | 9 | 3361 | 431 | 50601323 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Death | 911.25 | 40.08 | 586 | 3969 | 341498 | 29228474 |
Peritonitis bacterial | 867.25 | 40.08 | 196 | 4359 | 5560 | 29564412 |
Peritonitis | 542.18 | 40.08 | 164 | 4391 | 14660 | 29555312 |
Peritoneal dialysis complication | 496.10 | 40.08 | 99 | 4456 | 1498 | 29568474 |
Fungal peritonitis | 352.43 | 40.08 | 65 | 4490 | 627 | 29569345 |
Device interaction | 146.00 | 40.08 | 30 | 4525 | 525 | 29569447 |
Encapsulating peritoneal sclerosis | 138.83 | 40.08 | 29 | 4526 | 552 | 29569420 |
Myocardial infarction | 128.83 | 40.08 | 118 | 4437 | 110178 | 29459794 |
Cardiac disorder | 124.03 | 40.08 | 75 | 4480 | 37188 | 29532784 |
Ultrafiltration failure | 120.78 | 40.08 | 21 | 4534 | 139 | 29569833 |
Cardiac failure | 114.94 | 40.08 | 96 | 4459 | 79191 | 29490781 |
Peritoneal cloudy effluent | 103.67 | 40.08 | 18 | 4537 | 118 | 29569854 |
Gangrene | 101.33 | 40.08 | 34 | 4521 | 4184 | 29565788 |
Sepsis | 93.28 | 40.08 | 112 | 4443 | 142570 | 29427402 |
Hypervolaemia | 87.30 | 40.08 | 46 | 4509 | 17499 | 29552473 |
Noninfectious peritonitis | 84.56 | 40.08 | 15 | 4540 | 113 | 29569859 |
Cardiac arrest | 79.75 | 40.08 | 81 | 4474 | 85510 | 29484462 |
Cardiovascular disorder | 67.03 | 40.08 | 31 | 4524 | 8904 | 29561068 |
Catheter site infection | 63.50 | 40.08 | 20 | 4535 | 2012 | 29567960 |
Bloody peritoneal effluent | 54.39 | 40.08 | 10 | 4545 | 94 | 29569878 |
Drug ineffective | 44.47 | 40.08 | 3 | 4552 | 363167 | 29206805 |
Peritoneal effluent abnormal | 40.84 | 40.08 | 7 | 4548 | 42 | 29569930 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Peritonitis bacterial | 1211.38 | 36.75 | 246 | 4581 | 8797 | 64485108 |
Peritonitis | 628.64 | 36.75 | 176 | 4651 | 24847 | 64469058 |
Death | 599.72 | 36.75 | 395 | 4432 | 482310 | 64011595 |
Peritoneal dialysis complication | 540.86 | 36.75 | 100 | 4727 | 2128 | 64491777 |
Fungal peritonitis | 370.47 | 36.75 | 64 | 4763 | 907 | 64492998 |
Device interaction | 266.18 | 36.75 | 46 | 4781 | 652 | 64493253 |
Encapsulating peritoneal sclerosis | 212.71 | 36.75 | 39 | 4788 | 786 | 64493119 |
Sepsis | 133.15 | 36.75 | 121 | 4706 | 230220 | 64263685 |
Peritoneal cloudy effluent | 128.95 | 36.75 | 21 | 4806 | 202 | 64493703 |
Ultrafiltration failure | 119.63 | 36.75 | 20 | 4807 | 229 | 64493676 |
Cardiac arrest | 107.11 | 36.75 | 90 | 4737 | 153974 | 64339931 |
Gangrene | 106.94 | 36.75 | 34 | 4793 | 7304 | 64486601 |
Myocardial infarction | 93.46 | 36.75 | 86 | 4741 | 165735 | 64328170 |
Cardiac disorder | 81.02 | 36.75 | 51 | 4776 | 55765 | 64438140 |
Noninfectious peritonitis | 78.74 | 36.75 | 14 | 4813 | 235 | 64493670 |
Hypervolaemia | 71.12 | 36.75 | 41 | 4786 | 38244 | 64455661 |
Cardiac failure | 67.50 | 36.75 | 65 | 4762 | 132308 | 64361597 |
Bloody peritoneal effluent | 63.48 | 36.75 | 11 | 4816 | 158 | 64493747 |
Blood glucose false positive | 60.73 | 36.75 | 9 | 4818 | 43 | 64493862 |
Hypoglycaemia | 59.24 | 36.75 | 51 | 4776 | 89841 | 64404064 |
Complication associated with device | 53.64 | 36.75 | 25 | 4802 | 15055 | 64478850 |
Catheter site infection | 53.62 | 36.75 | 19 | 4808 | 5674 | 64488231 |
Drug ineffective | 45.57 | 36.75 | 5 | 4822 | 840242 | 63653663 |
Peritoneal effluent abnormal | 39.63 | 36.75 | 6 | 4821 | 34 | 64493871 |
Peritoneal disorder | 38.06 | 36.75 | 9 | 4818 | 640 | 64493265 |
None
Source | Code | Description |
---|---|---|
MeSH PA | D015314 | Dialysis Solutions |
MeSH PA | D019999 | Pharmaceutical Solutions |
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ID | Source |
---|---|
4021369 | VUID |
N0000148788 | NUI |
D03266 | KEGG_DRUG |
4021369 | VANDF |
C0538727 | UMLSCUI |
CHEMBL1201472 | ChEMBL_ID |
D000077607 | MESH_DESCRIPTOR_UI |
DB00702 | DRUGBANK_ID |
7048 | INN_ID |
2NX48Z0A9G | UNII |
1100743 | RXNORM |
19728 | MMSL |
59958 | MMSL |
006146 | NDDF |
412135003 | SNOMEDCT_US |
417226008 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
EXTRANEAL | HUMAN PRESCRIPTION DRUG LABEL | 5 | 0941-0679 | INJECTION, SOLUTION | 7.50 g | INTRAPERITONEAL | NDA | 25 sections |