minodronic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
calcium metabolism regulator, pharmaceutical aid	4074	180064-38-4

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

minodronic acid
minodronic acid hydrate
recalbon
minodronate
YM-529
YM529

Molecular weight: 322.15
Formula: C9H12N2O7P2
CLOGP: -0.24
LIPINSKI: 0
HAC: 9
HDO: 5
TPSA: 152.59
ALOGS: -1.57
ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
July 11, 2011	PMDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Atypical femur fracture	73.40	33.62	17	854	4899	50599354
Osteonecrosis of jaw	70.88	33.62	25	846	32501	50571752
Hepatic function abnormal	45.12	33.62	18	853	32663	50571590
Spinal compression fracture	44.61	33.62	14	857	12642	50591611
Upper respiratory tract inflammation	39.58	33.62	9	862	2380	50601873

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Osteonecrosis of jaw	76.25	28.48	29	1266	39796	64457641
Atypical femur fracture	66.33	28.48	16	1279	4682	64492755
Hepatic function abnormal	53.59	28.48	26	1269	64287	64433150
Spinal compression fracture	48.20	28.48	16	1279	14759	64482678
Upper respiratory tract inflammation	38.92	28.48	10	1285	3772	64493665
Interstitial lung disease	33.29	28.48	22	1273	97710	64399727

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Osteoporosis	indication	64859006	DOID:11476

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.11	acidic
pKa2	6.18	acidic
pKa3	7.16	acidic
pKa4	10.96	acidic
pKa5	11.56	acidic
pKa6	5.65	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Farnesyl pyrophosphate synthase	Enzyme	P14324	FPPS_HUMAN		IC50	8.52		CHEMBL
Geranylgeranyl pyrophosphate synthase	Enzyme	O95749	GGPPS_HUMAN		Ki	5.74		CHEMBL
Farnesyl diphosphate synthase	Enzyme		ISPA_ECOLI		IC50	5.96		CHEMBL
Geranylgeranyl pyrophosphate synthase	Enzyme		GGPPS_YEAST		Ki	6.89		CHEMBL

External reference:

ID	Source
D09198	KEGG_DRUG
C2825721	UMLSCUI
M0N	PDB_CHEM_ID
CHEMBL319144	ChEMBL_ID
DB06548	DRUGBANK_ID
130956	PUBCHEM_CID
3164	IUPHAR_LIGAND_ID
C087958	MESH_SUPPLEMENTAL_RECORD_UI
7651	INN_ID
40SGR63TGL	UNII

Pharmaceutical products:

None