minodronic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium metabolism regulator, pharmaceutical aid 4074 180064-38-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • minodronic acid
  • minodronic acid hydrate
  • recalbon
  • minodronate
  • YM-529
  • YM529
  • Molecular weight: 322.15
  • Formula: C9H12N2O7P2
  • CLOGP: -0.24
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 5
  • TPSA: 152.59
  • ALOGS: -1.57
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
July 11, 2011 PMDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Atypical femur fracture 73.40 33.62 17 854 4899 50599354
Osteonecrosis of jaw 70.88 33.62 25 846 32501 50571752
Hepatic function abnormal 45.12 33.62 18 853 32663 50571590
Spinal compression fracture 44.61 33.62 14 857 12642 50591611
Upper respiratory tract inflammation 39.58 33.62 9 862 2380 50601873

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Osteonecrosis of jaw 76.25 28.48 29 1266 39796 64457641
Atypical femur fracture 66.33 28.48 16 1279 4682 64492755
Hepatic function abnormal 53.59 28.48 26 1269 64287 64433150
Spinal compression fracture 48.20 28.48 16 1279 14759 64482678
Upper respiratory tract inflammation 38.92 28.48 10 1285 3772 64493665
Interstitial lung disease 33.29 28.48 22 1273 97710 64399727

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Osteoporosis indication 64859006 DOID:11476




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.11 acidic
pKa2 6.18 acidic
pKa3 7.16 acidic
pKa4 10.96 acidic
pKa5 11.56 acidic
pKa6 5.65 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Farnesyl pyrophosphate synthase Enzyme IC50 8.52 CHEMBL
Geranylgeranyl pyrophosphate synthase Enzyme Ki 5.74 CHEMBL
Farnesyl diphosphate synthase Enzyme IC50 5.96 CHEMBL
Geranylgeranyl pyrophosphate synthase Enzyme Ki 6.89 CHEMBL

External reference:

IDSource
D09198 KEGG_DRUG
C2825721 UMLSCUI
M0N PDB_CHEM_ID
CHEMBL319144 ChEMBL_ID
DB06548 DRUGBANK_ID
130956 PUBCHEM_CID
3164 IUPHAR_LIGAND_ID
C087958 MESH_SUPPLEMENTAL_RECORD_UI
7651 INN_ID
40SGR63TGL UNII

Pharmaceutical products:

None