baicalin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4055 | 21967-41-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
has iron chelating activity; chemical component of Chinese medicinal herb Huang-chin (Scutellaria baicalensis); do not confuse with baicalein
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:22586 | antioxidants |
| CHEBI has role | CHEBI:33282 | bactericides |
| CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory agent |
| CHEBI has role | CHEBI:35610 | antineoplastic agents |
| CHEBI has role | CHEBI:50266 | Prodrugs |
| CHEBI has role | CHEBI:63726 | neuroprotective agents |
| CHEBI has role | CHEBI:76779 | post-proline endopeptidase inhibitors |
| CHEBI has role | CHEBI:76924 | plant metabolites |
| CHEBI has role | CHEBI:77307 | cardioprotective agents |
| CHEBI has role | CHEBI:145947 | antiatherosclerotic agents |
| CHEBI has role | CHEBI:149553 | anticoronaviral drug |
| CHEBI has role | CHEBI:170010 | EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitors |
| CHEBI has role | CHEBI:173084 | ferroptosis inhibitors |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D018712 | Analgesics, Non-Narcotic |
| MeSH PA | D018927 | Anti-Asthmatic Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
| MeSH PA | D018501 | Antirheumatic Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D019141 | Respiratory System Agents |
| MeSH PA | D018689 | Sensory System Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.86 | acidic |
| pKa2 | 6.55 | acidic |
| pKa3 | 9.09 | acidic |
| pKa4 | 11.71 | acidic |
| pKa5 | 12.49 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Cyclin-dependent kinase 1 | Kinase | IC50 | 4.84 | CHEMBL | |||||
| Serine/threonine-protein kinase PLK1 | Kinase | IC50 | 5.44 | CHEMBL | |||||
| Prolyl endopeptidase | Enzyme | IC50 | 4.92 | CHEMBL | |||||
| Lysine-specific histone demethylase 1A | Enzyme | IC50 | 5.45 | CHEMBL | |||||
| GABA-A receptor; anion channel | Ion channel | Ki | 4.11 | CHEMBL | |||||
| Replicase polyprotein 1ab | Enzyme | IC50 | 5.19 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4028922 | VUID |
| N0000179808 | NUI |
| 4028922 | VANDF |
| C0052929 | UMLSCUI |
| CHEBI:2981 | CHEBI |
| 0XE | PDB_CHEM_ID |
| CHEMBL485818 | ChEMBL_ID |
| C038044 | MESH_SUPPLEMENTAL_RECORD_UI |
| C088236 | MESH_SUPPLEMENTAL_RECORD_UI |
| 347Q89U4M5 | UNII |
| 64982 | PUBCHEM_CID |
| 1440261 | RXNORM |
| 008594 | NDDF |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Anubis Barcelona | HUMAN OTC DRUG LABEL | 24 | 83021-553 | CREAM | 0.01 g | TOPICAL | OTC monograph final | 9 sections |