bromhexine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| mucolytic, bromhexine derivatives | 402 | 3572-43-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744)
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 24 | mg | O |
| 24 | mg | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 77.50 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Pneumonia aspiration | 108.86 | 26.27 | 36 | 1187 | 34504 | 63453295 |
| Underdose | 68.32 | 26.27 | 24 | 1199 | 27432 | 63460367 |
| Coma | 67.17 | 26.27 | 30 | 1193 | 64334 | 63423465 |
| Gastrooesophageal reflux disease | 64.46 | 26.27 | 33 | 1190 | 95606 | 63392193 |
| Renal tubular atrophy | 55.11 | 26.27 | 10 | 1213 | 766 | 63487033 |
| Nephrosclerosis | 52.06 | 26.27 | 10 | 1213 | 1044 | 63486755 |
| Tubulointerstitial nephritis | 47.96 | 26.27 | 17 | 1206 | 19886 | 63467913 |
| Kidney fibrosis | 46.28 | 26.27 | 10 | 1213 | 1871 | 63485928 |
| Somnolence | 45.40 | 26.27 | 33 | 1190 | 178652 | 63309147 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Pneumonia | 44.05 | 28.83 | 50 | 853 | 362577 | 34593451 |
| Pneumonia aspiration | 31.04 | 28.83 | 17 | 886 | 41886 | 34914142 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Pneumonia aspiration | 115.08 | 21.46 | 50 | 2252 | 66917 | 79675169 |
| Pneumonia | 56.11 | 21.46 | 81 | 2221 | 660165 | 79081921 |
| Underdose | 54.40 | 21.46 | 24 | 2278 | 33127 | 79708959 |
| Gastrooesophageal reflux disease | 49.23 | 21.46 | 33 | 2269 | 104213 | 79637873 |
| Coma | 47.86 | 21.46 | 32 | 2270 | 100617 | 79641469 |
| Nephrosclerosis | 42.51 | 21.46 | 10 | 2292 | 1820 | 79740266 |
| Renal tubular atrophy | 42.37 | 21.46 | 10 | 2292 | 1846 | 79740240 |
| Kidney fibrosis | 35.97 | 21.46 | 10 | 2292 | 3525 | 79738561 |
| Tubulointerstitial nephritis | 33.42 | 21.46 | 18 | 2284 | 38217 | 79703869 |
| Upper respiratory tract inflammation | 30.26 | 21.46 | 9 | 2293 | 4026 | 79738060 |
| Somnolence | 27.29 | 21.46 | 34 | 2268 | 238947 | 79503139 |
| Pyrexia | 22.70 | 21.46 | 56 | 2246 | 678653 | 79063433 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R05CB02 | RESPIRATORY SYSTEM COUGH AND COLD PREPARATIONS EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS Mucolytics |
| MeSH PA | D005100 | Expectorants |
| MeSH PA | D019141 | Respiratory System Agents |
| CHEBI has role | CHEBI:77034 | mucolytics |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.16 | Basic |
| pKa2 | 0.87 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 7.60 | DRUG MATRIX | |||||
| Sodium-dependent serotonin transporter | Transporter | Ki | 5.95 | DRUG MATRIX | |||||
| Cytochrome P450 2D6 | Enzyme | IC50 | 6.71 | DRUG MATRIX | |||||
| Membrane-associated progesterone receptor component 1 | Membrane receptor | Ki | 7.44 | DRUG MATRIX |
External reference:
| ID | Source |
|---|---|
| N0000166541 | NUI |
| D01778 | KEGG_DRUG |
| 1601 | RXNORM |
| C0006220 | UMLSCUI |
| CHEBI:77032 | CHEBI |
| CHEMBL253376 | ChEMBL_ID |
| DB09019 | DRUGBANK_ID |
| D001964 | MESH_DESCRIPTOR_UI |
| 2442 | PUBCHEM_CID |
| 11218 | IUPHAR_LIGAND_ID |
| 2584 | INN_ID |
| 611-75-6 | SECONDARY_CAS_RN |
| Q1J152VB1P | UNII |
| NOCODE | MMSL |
| 412102008 | SNOMEDCT_US |
| 708561003 | SNOMEDCT_US |
| 846647005 | SNOMEDCT_US |
| CHEMBL1319139 | ChEMBL_ID |
| 003678 | NDDF |
| 003679 | NDDF |
Pharmaceutical products:
None