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| Stem definition | Drug id | CAS RN |
|---|---|---|
| polymers | 4021 | 87806-31-3 |
| Molecule | Description |
|---|---|
|
Synonyms:
|
The purified component of HEMATOPORPHYRIN DERIVATIVE, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (HEMATOPORPHYRIN PHOTORADIATION); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of PHOTODYNAMIC THERAPY in the United States.
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| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 0 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
None
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 27, 1995 | FDA | CONCORDIA LABS INC |
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| Source | Code | Description |
|---|---|---|
| ATC | L01XD01 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Sensitizers used in photodynamic/radiation therapy |
| FDA PE | N0000009801 | Photosensitizing Activity |
| FDA MoA | N0000010217 | Photoabsorption |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D003879 | Dermatologic Agents |
| MeSH PA | D011838 | Radiation-Sensitizing Agents |
| MeSH PA | D017319 | Photosensitizing Agents |
| FDA EPC | N0000175984 | Photoactivated Radical Generator |
| CHEBI has role | CHEBI:22587 | antiviral agent |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:47868 | photosensitizing agent |
| CHEBI has role | CHEBI:50177 | dermatologic drug |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Non-small cell lung cancer | indication | 254637007 | DOID:3908 |
| Malignant tumor of esophagus | indication | 363402007 | |
| Endoscopic Photodynamic Ablation Adjunct for Cancer or High Grade Dysplasia | indication | ||
| High Grade Dysplasia associated with Barrett's Esophagus | indication | ||
| Esophageal varices | contraindication | 28670008 | |
| Ulcer of esophagus | contraindication | 30811009 | |
| Stricture of esophagus | contraindication | 63305008 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Tracheoesophageal fistula | contraindication | 95435007 | |
| Bronchoesophageal fistula | contraindication | 235641005 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Thromboembolic disorder | contraindication | 371039008 | |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Porphyria | contraindication | 418470004 | |
| Bronchial Erosion due to Malignant Esophagus Neoplasm | contraindication | ||
| Tracheal Erosion due to Malignant Esophagus Neoplasm | contraindication | ||
| Arterial Erosion by Tumor Growth | contraindication |
None
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| ID | Source |
|---|---|
| 4024058 | VUID |
| N0000022063 | NUI |
| D03327 | KEGG_DRUG |
| 4024058 | VANDF |
| 4039127 | VANDF |
| C0058031 | UMLSCUI |
| CHEMBL1201481 | ChEMBL_ID |
| M15H03K69B | UNII |
| DB00707 | DRUGBANK_ID |
| 225244 | RXNORM |
| 11252 | MMSL |
| 5320 | MMSL |
| d03872 | MMSL |
| 006198 | NDDF |
| 006199 | NDDF |
| 108816003 | SNOMEDCT_US |
| 372545008 | SNOMEDCT_US |
| 386921007 | SNOMEDCT_US |
| D017323 | MESH_DESCRIPTOR_UI |
| CHEBI:60773 | CHEBI |
| 129627869 | PUBCHEM_CID |
| 6670 | INN_ID |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Photofrin | Human Prescription Drug Label | 1 | 76128-155 | INJECTION, POWDER, FOR SOLUTION | 75 mg | INTRAVENOUS | NDA | 20 sections |