brodimoprim 🐢 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibacterials, dihydrofolate reductase (DHFR) inhibitors, trimethoprim derivatives 398 56518-41-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • brodimoprim
  • unitrim
inhibits dihydrofolate reductase
  • Molecular weight: 339.19
  • Formula: C13H15BrN4O2
  • CLOGP: 2.16
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 96.28
  • ALOGS: -3
  • ROTB: 4

Drug dosage:

DoseUnitRoute
0.20 g O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 9.27 Β΅M/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1993 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01EA02 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Trimethoprim and derivatives
MeSH PA D000890 Anti-Infective Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005493 Folic Acid Antagonists
CHEBI has role CHEBI:35441 antiinfective agents
CHEBI has role CHEBI:36047 antibacterial drugs
CHEBI has role CHEBI:50683 dihydrofolic acid reductase inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐢 Veterinary Drug Use

None

🐢 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.01 Basic
pKa2 0.6 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme IC50 7.77 CHEMBL
Dihydrofolate reductase Enzyme IC50 7.51 CHEMBL
Dihydrofolate reductase Enzyme IC50 7.82 CHEMBL
Dihydrofolate reductase Enzyme Ki 8.18 WOMBAT-PK
Dihydrofolate reductase Enzyme Ki 7.95 CHEMBL
Dihydrofolate reductase Enzyme Ki 4.54 CHEMBL
Dihydrofolate reductase Enzyme IC50 8.53 CHEMBL
Dihydrofolate reductase Enzyme Ki 8.18 CHEMBL

External reference:

IDSource
D07238 KEGG_DRUG
19727 RXNORM
C0054084 UMLSCUI
CHEBI:131726 CHEBI
CHEMBL31891 ChEMBL_ID
DB13795 DRUGBANK_ID
C037079 MESH_SUPPLEMENTAL_RECORD_UI
68760 PUBCHEM_CID
4910 INN_ID
V1YC7T6LLI UNII
006013 NDDF

Pharmaceutical products:

None