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iclaprim 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antimicrobials, dihydrofolate reductase (DHFR) inhibitors, trimethoprim analogues | 4573 | 192314-93-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
has antiviral activity
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 41 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,ERBB2,GRK2,MAP3K21,MAPK7,PDK2,PDK4,PIK3CA,PIK3CD,PIK3CG,PRKDC | 13 | |||
| kinase-selectivity-class | ACVR2B,AXL,EIF2AK3,MAP3K21,PIK3CD,PRKDC | 6 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01EA03 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE SULFONAMIDES AND TRIMETHOPRIM Trimethoprim and derivatives |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D005493 | Folic Acid Antagonists |
| CHEBI has role | CHEBI:33282 | antibacterial agent |
| CHEBI has role | CHEBI:35441 | antiinfective agent |
| CHEBI has role | CHEBI:36047 | antibacterial drug |
| CHEBI has role | CHEBI:50683 | EC 1.5.1.3 (dihydrofolate reductase) inhibitor |
Related Drugs by ATC class:
J01EA Trimethoprim and derivatives 2 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.01 | Basic |
| pKa2 | 0.6 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Dihydrofolate reductase | Enzyme | Ki | 6.11 | CHEMBL | |||||
| Dihydrofolate reductase | Enzyme | IC50 | 5.62 | CHEMBL | |||||
| Dihydrofolate reductase | Enzyme | IC50 | 8.15 | CHEMBL | |||||
| Dihydrofolate reductase | Enzyme | IC50 | 8.15 | CHEMBL | |||||
| Dihydrofolate reductase | Enzyme | Ki | 10.10 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D08337 | KEGG_DRUG |
| CHEMBL134561 | ChEMBL_ID |
| CHEMBL2105645 | ChEMBL_ID |
| C486448 | MESH_SUPPLEMENTAL_RECORD_UI |
| 10820 | IUPHAR_LIGAND_ID |
| 8315 | INN_ID |
| 474793-41-4 | SECONDARY_CAS_RN |
| DB06358 | DRUGBANK_ID |
| 42445HUU0O | UNII |
| 725576004 | SNOMEDCT_US |
| C3654387 | UMLSCUI |
| 213043 | PUBCHEM_CID |
Pharmaceutical products:
None