ilaprazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antiulcer, benzimidazole derivatives 3961 172152-36-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • IY-81149
  • IY81149
  • IY 81149
  • ilaprazole
  • noltec
  • Molecular weight: 366.44
  • Formula: C19H18N4O2S
  • CLOGP: 3.13
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 72.80
  • ALOGS: -3.59
  • ROTB: 5

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.19 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.73 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.59 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Oct. 28, 2008 Korean Food and Drug Administration (KFDA)

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Occupational dermatitis 85.22 84.40 9 84 92 34956746

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Occupational dermatitis 85.02 66.00 9 130 146 79744103
Occupational exposure to air contaminants 74.15 66.00 8 131 156 79744093

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Gastroesophageal reflux disease indication 235595009 DOID:8534




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.28 acidic
pKa2 4.05 Basic
pKa3 3.35 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Potassium-transporting ATPase Transporter INHIBITOR SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
C1881129 UMLSCUI
CHEBI:135544 CHEBI
CHEMBL2106370 ChEMBL_ID
DB11964 DRUGBANK_ID
C119615 MESH_SUPPLEMENTAL_RECORD_UI
214351 PUBCHEM_CID
10512 IUPHAR_LIGAND_ID
8158 INN_ID
776Q6XX45J UNII

Pharmaceutical products:

None