Molfile
Inchi
Smiles
Synonyms:
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MDL 73,147EF
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dolasetron methanesulfonate hydrate
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dolasetron mesylate hydrate
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anzemet hydrate
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anzemet
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dolasetron
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anemet
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dolasetron mesylate
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dolasetron mesilate
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Dolasetron mesylate is an antinauseant and antiemetic agent. Dolasetron mesylate and its active metabolite, hydrodolasetron (MDL 74,156), are selective serotonin 5-HT3 receptor antagonists not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors. The serotonin 5-HT3 receptors are located on the nerve terminals of the vagus in the periphery and centrally in the chemoreceptor trigger zone of the area postrema.
- Molecular weight: 324.38
- Formula: C19H20N2O3
- CLOGP: 1.92
- LIPINSKI: 0
- HAC: 5
- HDO: 1
- TPSA: 62.40
- ALOGS: -3.09
- ROTB: 3
- Status: OFP
Legend: OFP - off patent OFM - off market ONP - on patent
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