androstanolone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
steroids, androgens 3927 521-18-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • neodrol
  • androstanolone
  • androlone
  • dihydrotestosterone
  • stanolone
A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.
  • Molecular weight: 290.45
  • Formula: C19H30O2
  • CLOGP: 3.55
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -4.46
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC A14AA01 ALIMENTARY TRACT AND METABOLISM
ANABOLIC AGENTS FOR SYSTEMIC USE
ANABOLIC STEROIDS
Androstan derivatives
ATC G03BB02 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
ANDROGENS
5-androstanon (3) derivatives
MeSH PA D000728 Androgens
MeSH PA D006728 Hormones

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Anemia of chronic renal failure indication 49708008
Catabolic Process indication
Turner syndrome off-label use 38804009 DOID:3491
Congenital hypoplastic anemia off-label use 88854002 DOID:1339
Hb SS disease off-label use 127040003 DOID:10923
Hypercholesterolemia contraindication 13644009
Myocardial infarction contraindication 22298006 DOID:5844
Obstruction of bile duct contraindication 30144000
Renal failure syndrome contraindication 42399005 DOID:1074
Body fluid retention contraindication 43498006
Humoral hypercalcemia of malignancy contraindication 47709007
Nephrotic syndrome contraindication 52254009 DOID:1184
Heart disease contraindication 56265001 DOID:114
Peliosis hepatis contraindication 58008004 DOID:914
Blood coagulation disorder contraindication 64779008 DOID:1247
Hypercalcemia contraindication 66931009 DOID:12678
Arteriosclerotic vascular disease contraindication 72092001
Diabetes mellitus contraindication 73211009 DOID:9351
Heart failure contraindication 84114007 DOID:6000
Kidney disease contraindication 90708001 DOID:557
Cholestatic hepatitis contraindication 95556007
Neoplasm of liver contraindication 126851005 DOID:3571
Neoplasm of prostate contraindication 126906006 DOID:10283
Hypoalphalipoproteinemia contraindication 190785000
Decompensated cardiac failure contraindication 195111005
Disease of liver contraindication 235856003 DOID:409
Benign prostatic hyperplasia contraindication 266569009
Edema contraindication 267038008
Pregnancy, function contraindication 289908002
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Breast Carcinoma in Males contraindication

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Aromatase Enzyme Ki 6.66 CHEMBL
Sex hormone-binding globulin Secreted Kd 9.74 CHEMBL
Androgen receptor Nuclear hormone receptor Ki 9.70 CHEMBL
Corticosteroid-binding globulin Secreted Ki 5.92 CHEMBL
Progesterone receptor Transcription factor Ki 6.79 DRUG MATRIX
Androgen receptor Transcription factor IC50 9 CHEMBL
Glucocorticoid receptor Transcription factor IC50 4.70 CHEMBL
Androgen receptor Transcription factor Ki 9.57 CHEMBL
Mineralocorticoid receptor Transcription factor IC50 5.68 CHEMBL
Progesterone receptor Transcription factor IC50 6.36 CHEMBL

External reference:

IDSource
D07456 KEGG_DRUG
08J2K08A3Y UNII
238 INN_ID
56032002 SNOMEDCT_US
103042004 SNOMEDCT_US
003255 NDDF
005232 NDDF
CHEBI:16330 CHEBI
CHEMBL27769 ChEMBL_ID
DB02901 DRUGBANK_ID
2856 IUPHAR_LIGAND_ID
10635 PUBCHEM_CID
D013196 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None