clobetasone butyrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3911	25122-57-0

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

eumovate
kindavate
clobetasone butyrate
21-Chloro-11-dehydrobetamethasone
clobetasone 17-butyrate

Molecular weight: 478.99
Formula: C26H32ClFO5
CLOGP: 4.21
LIPINSKI: 0
HAC: 5
HDO: 0
TPSA: 77.51
ALOGS: -5.44
ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	PMDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Steroid withdrawal syndrome	96.54	39.62	16	1637	529	63486840
Skin weeping	78.07	39.62	14	1639	739	63486630
Skin exfoliation	76.63	39.62	32	1621	43070	63444299
Skin burning sensation	46.43	39.62	16	1637	12718	63474651
Pruritus	45.13	39.62	51	1602	361402	63125967
Eczema	41.18	39.62	19	1634	32272	63455097

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Skin weeping	85.19	37.50	16	2180	1031	79741161
Steroid withdrawal syndrome	84.48	37.50	15	2181	706	79741486
Skin exfoliation	79.79	37.50	36	2160	55064	79687128
Rash	57.95	37.50	75	2121	578283	79163909
Skin burning sensation	56.51	37.50	19	2177	13253	79728939
Eczema	47.66	37.50	23	2173	40795	79701397
Burns second degree	44.36	37.50	11	2185	2617	79739575
Steroid dependence	44.35	37.50	11	2185	2619	79739573
Medication error	44.18	37.50	26	2170	68616	79673576
Pruritus	42.25	37.50	53	2143	394595	79347597
Catarrh	41.25	37.50	10	2186	2168	79740024

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D07AB01	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, moderately potent (group II)
ATC	S01BA09	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS Corticosteroids, plain
ATC	S01CA11	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION Corticosteroids and antiinfectives in combination
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D005938	Glucocorticoids
MeSH PA	D006728	Hormones

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Atopic dermatitis	indication	24079001	DOID:3310
Eczema	indication	43116000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN	AGONIST				KEGG DRUG	KEGG DRUG

External reference:

ID	Source
D01273	KEGG_DRUG
C0055896	UMLSCUI
CHEBI:31415	CHEBI
CHEMBL2308885	ChEMBL_ID
C010893	MESH_SUPPLEMENTAL_RECORD_UI
8U0H6XI6EO	UNII
71386	PUBCHEM_CID
DB13158	DRUGBANK_ID
108074	RXNORM
003809	NDDF
003810	NDDF
116576003	SNOMEDCT_US
395963000	SNOMEDCT_US
395967004	SNOMEDCT_US
C0360518	UMLSCUI
3155	INN_ID
54063-32-0	SECONDARY_CAS_RN
71387	PUBCHEM_CID
9088	IUPHAR_LIGAND_ID
LT69WY1J6D	UNII

Pharmaceutical products:

None