biriperone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
tranquillizers, neuroleptics, 4'-fluoro-4-piperidinobutyrophenone derivatives	3883	42021-34-1

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

biriperone
centbutindole

Molecular weight: 391.49
Formula: C24H26FN3O
CLOGP: 4.57
LIPINSKI: 0
HAC: 4
HDO: 1
TPSA: 39.34
ALOGS: -4.23
ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	12.44	acidic
pKa2	7.64	Basic
pKa3	3.59	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	7.96		CHEMBL
D(2) dopamine receptor	GPCR		DRD2_RAT		Ki	7.88		CHEMBL
5-hydroxytryptamine receptor 2A	GPCR		5HT2A_RAT		Ki	7.62		CHEMBL
D(1A) dopamine receptor	GPCR		DRD1_RAT		Ki	6.37		CHEMBL

External reference:

ID	Source
C2698513	UMLSCUI
CHEBI:135615	CHEBI
CHEMBL136711	ChEMBL_ID
68663	PUBCHEM_CID
C039923	MESH_SUPPLEMENTAL_RECORD_UI
5472	INN_ID
5776HBV7UD	UNII
41510-23-0	SECONDARY_CAS_RN

Pharmaceutical products:

None