DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
Similarity ๐
Smart API
Redial
About
Download
L1000
FAQ
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
blonanserin ๐ถ
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
serotonin receptor antagonists (mostly 5-HT2)
388
132810-10-7
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
blonanserin
lonasen
AD-5423
Molecular weight: 367.51
Formula: C23H30FN3
CLOGP: 6.73
LIPINSKI: 1
HAC: 3
HDO: 0
TPSA: 19.37
ALOGS: -4.01
ROTB: 3
Drug dosage:
None
ADMET properties:
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Property
Value
Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)
0.93 ยตM/kg/day
Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
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Approvals:
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Date
Agency
Company
Orphan
Jan. 25, 2008
PMDA
Dainippon Sumitomo Pharma Co., Ltd.
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FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Psychiatric symptom
81.18
48.86
16
441
5207
63483358
Salivary hypersecretion
52.80
48.86
12
445
7654
63480911
Parkinsonism
49.11
48.86
12
445
10427
63478138
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FDA Adverse Event Reporting System (Male)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Procedural failure
49.29
43.41
6
283
67
34956575
Floppy iris syndrome
48.32
43.41
7
282
310
34956332
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1
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FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Psychiatric symptom
97.77
41.35
21
825
7014
79736528
Hallucination, auditory
66.18
41.35
19
827
20674
79722868
Salivary hypersecretion
54.27
41.35
15
831
14209
79729333
Procedural failure
46.50
41.35
6
840
84
79743458
Floppy iris syndrome
45.57
41.35
7
839
356
79743186
Pneumonia aspiration
44.35
41.35
19
827
66948
79676594
Parkinsonism
43.21
41.35
13
833
16571
79726971
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Schizophrenia
indication
58214004
DOID:5419
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๐ถ Veterinary Drug Use
None
๐ถ Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
9.05
Basic
pKa2
5.85
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
D(2) dopamine receptor
GPCR
P14416
DRD2_HUMAN
ANTAGONIST
Ki
9.85
SCIENTIFIC LITERATURE
SCIENTIFIC LITERATURE
5-hydroxytryptamine receptor 2A
GPCR
P28223
5HT2A_HUMAN
ANTAGONIST
Ki
9.09
SCIENTIFIC LITERATURE
SCIENTIFIC LITERATURE
Sigma non-opioid intracellular receptor 1
Membrane receptor
Q99720
SGMR1_HUMAN
Ki
6.54
WOMBAT-PK
Alpha-1A adrenergic receptor
GPCR
P35348
ADA1A_HUMAN
Ki
7.25
WOMBAT-PK
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External reference:
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ID
Source
125564
PUBCHEM_CID
7563
INN_ID
7670
IUPHAR_LIGAND_ID
AQ316B4F8C
UNII
C0287983
UMLSCUI
C079310
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:31296
CHEBI
CHEMBL178803
ChEMBL_ID
D01176
KEGG_DRUG
DB09223
DRUGBANK_ID
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Pharmaceutical products:
None
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blonanserin