bisulepine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
tricyclic compounds	383	5802-61-9

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

bisulepin
bisulepine
dithiaden

Molecular weight: 301.47
Formula: C17H19NS2
CLOGP: 4.22
LIPINSKI: 0
HAC: 1
HDO: 0
TPSA: 3.24
ALOGS: -4.75
ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Haemolytic uraemic syndrome	65.18	53.84	11	160	2275	34954485

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Haemolytic uraemic syndrome	55.19	39.88	11	476	4438	79739463
Cytokine release syndrome	53.08	39.88	16	471	35982	79707919
COVID-19 pneumonia	43.26	39.88	13	474	28836	79715065
Embolic pneumonia	40.61	39.88	5	482	85	79743816

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.66	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN	ANTAGONIST				KEGG DRUG	KEGG DRUG

External reference:

ID	Source
D07532	KEGG_DRUG
42504-83-6	SECONDARY_CAS_RN
CHEBI:135277	CHEBI
C0058491	UMLSCUI
6537425	PUBCHEM_CID
595726R32U	UNII

Pharmaceutical products:

None