bisacodyl 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
vasodilators	375	603-50-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: bisacodyl brocalax dulcolax	A diphenylmethane stimulant laxative used for the treatment of CONSTIPATION and for bowel evacuation. (From Martindale, The Extra Pharmacopoeia, 30th ed, p871) Molecular weight: 361.40 Formula: C22H19NO4 CLOGP: 2.85 LIPINSKI: 0 HAC: 5 HDO: 0 TPSA: 65.49 ALOGS: -5.46 ROTB: 7 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

bisacodyl
brocalax
dulcolax

A diphenylmethane stimulant laxative used for the treatment of CONSTIPATION and for bowel evacuation. (From Martindale, The Extra Pharmacopoeia, 30th ed, p871)

Molecular weight: 361.40
Formula: C22H19NO4
CLOGP: 2.85
LIPINSKI: 0
HAC: 5
HDO: 0
TPSA: 65.49
ALOGS: -5.46
ROTB: 7

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
10	mg	O
10	mg	R

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	15 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
S (Water solubility)	0.00 mg/mL	Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
May 10, 2004	FDA	BRAINTREE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	711.60	13.29	287	23639	24089	63441007
Sedation complication	470.63	13.29	182	23744	13640	63451456
Orthostatic hypotension	460.29	13.29	239	23687	35921	63429175
Creatinine renal clearance decreased	438.06	13.29	181	23745	16127	63448969
Cognitive disorder	428.68	13.29	265	23661	55550	63409546
Sedation	405.56	13.29	225	23701	38584	63426512
Blood calcium decreased	363.06	13.29	184	23742	26267	63438829
Hypomania	314.05	13.29	110	23816	6220	63458876
Jaundice cholestatic	305.77	13.29	112	23814	7212	63457884
Balance disorder	304.43	13.29	253	23673	84169	63380927
Schizophrenia	272.42	13.29	112	23814	9840	63455256
Depressed level of consciousness	246.78	13.29	197	23729	61881	63403215
Psychotic disorder	214.94	13.29	129	23797	25583	63439513
Hypotension	163.65	13.29	334	23592	272270	63192826
Blood bilirubin increased	158.57	13.29	123	23803	37017	63428079
Mobility decreased	155.14	13.29	209	23717	120950	63344146
Hepatotoxicity	143.80	13.29	116	23810	36925	63428171
Fall	141.31	13.29	394	23532	391940	63073156
Chronic sinusitis	135.49	13.29	75	23851	12768	63452328
Cholelithiasis	132.51	13.29	119	23807	43806	63421290
Constipation	124.80	13.29	267	23659	224676	63240420
Paraesthesia oral	119.38	13.29	80	23846	19176	63445920
Procedural pain	108.89	13.29	79	23847	21490	63443606
Asthma-chronic obstructive pulmonary disease overlap syndrome	106.76	13.29	37	23889	2024	63463072
Total lung capacity increased	102.63	13.29	37	23889	2273	63462823
Toxicity to various agents	99.54	13.29	259	23667	246991	63218105
Vaginal flatulence	83.15	13.29	35	23891	3258	63461838
Proctitis	72.11	13.29	37	23889	5404	63459692
Nasal polyps	71.28	13.29	38	23888	6001	63459095
Rheumatoid arthritis	70.51	13.29	7	23919	253812	63211284
Intestinal pseudo-obstruction	69.85	13.29	22	23904	890	63464206
Drug intolerance	68.79	13.29	16	23910	308645	63156451
Alopecia	68.61	13.29	21	23905	337515	63127581
Bronchiectasis	63.57	13.29	51	23875	16091	63449005
Systemic lupus erythematosus	62.93	13.29	4	23922	208914	63256182
Sarcoidosis	62.78	13.29	37	23889	7085	63458011
Multiple drug therapy	60.83	13.29	29	23897	3617	63461479
Arthropathy	59.04	13.29	9	23917	234783	63230313
Joint swelling	58.76	13.29	25	23901	327641	63137455
Maternal exposure during pregnancy	58.75	13.29	7	23919	220055	63245041
Contraindicated product administered	57.91	13.29	7	23919	217641	63247455
Treatment failure	56.57	13.29	5	23921	199038	63266058
Female genital tract fistula	55.67	13.29	35	23891	7524	63457572
Vaginal discharge	51.74	13.29	36	23890	9162	63455934
Radiculopathy	51.50	13.29	35	23891	8576	63456520
Rhinitis allergic	50.37	13.29	39	23887	11688	63453408
Cardiac murmur	46.99	13.29	41	23885	14511	63450585
Arthralgia	46.78	13.29	90	23836	569620	62895476
Wound	46.66	13.29	4	23922	163259	63301837
Hypersensitivity	44.05	13.29	28	23898	292657	63172439
Therapeutic product effect decreased	43.03	13.29	10	23916	193177	63271919
Nausea	40.05	13.29	494	23432	853977	62611119
Rash	39.09	13.29	97	23829	560774	62904322
Pericarditis	35.56	13.29	4	23922	131575	63333521
Oral candidiasis	34.87	13.29	43	23883	22755	63442341
Pneumonia	34.75	13.29	292	23634	456475	63008621
Nasopharyngitis	34.72	13.29	27	23899	254230	63210866
Product use issue	34.70	13.29	20	23906	220500	63244596
Lung neoplasm malignant	33.25	13.29	39	23887	19594	63445502
Drug hypersensitivity	33.18	13.29	41	23885	310646	63154450
Frequent bowel movements	32.94	13.29	42	23884	22980	63442116
Vomiting	31.25	13.29	335	23591	559282	62905814
Chronic obstructive pulmonary disease	30.80	13.29	71	23855	62615	63402481
Pain	30.75	13.29	419	23507	740209	62724887
Sinusitis	29.78	13.29	25	23901	226628	63238468
Exposure during pregnancy	29.26	13.29	11	23915	155536	63309560
Urinary retention	28.16	13.29	45	23881	30256	63434840
Abdominal pain	27.49	13.29	197	23729	293259	63171837
Abdominal discomfort	26.87	13.29	50	23876	320835	63144261
Swelling	25.73	13.29	40	23886	275338	63189758
Atonic urinary bladder	25.09	13.29	6	23920	84	63465012
Oedema peripheral	25.08	13.29	139	23787	189372	63275724
Colitis	24.99	13.29	56	23870	48472	63416624
Infection	24.71	13.29	30	23896	229143	63235953
Death	24.65	13.29	232	23694	374149	63090947
Dyspepsia	23.28	13.29	88	23838	102108	63362988
Colitis ulcerative	23.22	13.29	38	23888	26053	63439043
Peripheral swelling	22.65	13.29	41	23885	265901	63199195
Prescription drug used without a prescription	22.63	13.29	13	23913	2373	63462723
Loss of bladder sensation	22.10	13.29	5	23921	54	63465042
Pain in extremity	21.75	13.29	59	23867	331427	63133669
Haematochezia	21.37	13.29	56	23870	53488	63411608
Total lung capacity decreased	20.99	13.29	12	23914	2171	63462925
Listless	20.45	13.29	13	23913	2847	63462249
Psoriasis	20.37	13.29	4	23922	86953	63378143
Foreign body	20.22	13.29	12	23914	2326	63462770
Mental status changes	19.61	13.29	45	23881	39554	63425542
Reduced facial expression	19.42	13.29	11	23915	1955	63463141
Completed suicide	19.20	13.29	16	23910	145657	63319439
Anal sphincter atony	19.02	13.29	6	23920	244	63464852
Arthritis	18.97	13.29	10	23916	115911	63349185
Flatulence	18.94	13.29	41	23885	34661	63430435
Fatigue	18.63	13.29	230	23696	887798	62577298
Impaired healing	18.06	13.29	8	23918	102534	63362562
Musculoskeletal stiffness	18.02	13.29	26	23900	184592	63280504
Bronchopulmonary aspergillosis allergic	18.01	13.29	11	23915	2247	63462849
Drug dose titration not performed	17.91	13.29	7	23919	538	63464558
Hypoxia	17.54	13.29	56	23870	59736	63405360
Female sexual arousal disorder	17.53	13.29	4	23922	45	63465051
Anticholinergic syndrome	17.46	13.29	11	23915	2371	63462725
Delirium	17.32	13.29	50	23876	50491	63414605
Body dysmorphic disorder	17.14	13.29	6	23920	338	63464758
Folliculitis	16.98	13.29	3	23923	70314	63394782
Lung opacity	16.89	13.29	12	23914	3156	63461940
Subileus	16.85	13.29	12	23914	3167	63461929
Gastrooesophageal reflux disease	16.78	13.29	76	23850	95563	63369533
Gastrointestinal disorder	16.59	13.29	15	23911	131224	63333872
Urticaria	16.53	13.29	23	23903	165779	63299317
Hypokalaemia	16.39	13.29	80	23846	103724	63361372
Rectal haemorrhage	16.32	13.29	48	23878	48982	63416114
Weight decreased	15.99	13.29	167	23759	276631	63188465
Oesophageal hypomotility	15.88	13.29	5	23921	202	63464894
Mutism	15.78	13.29	9	23917	1621	63463475
Irritable bowel syndrome	15.21	13.29	6	23920	82406	63382690
Intestinal obstruction	15.17	13.29	35	23891	30864	63434232
Discomfort	14.97	13.29	25	23901	167349	63297747
Hyponatraemia	14.73	13.29	82	23844	111818	63353278
Interstitial lung disease	14.19	13.29	3	23923	61905	63403191
Pelvic fracture	14.05	13.29	21	23905	13327	63451769
Headache	14.01	13.29	162	23764	633079	62832017
Injection site pain	13.97	13.29	17	23909	129783	63335313
Anorgasmia	13.87	13.29	6	23920	597	63464499
Pericoronitis	13.76	13.29	3	23923	27	63465069

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	288.16	13.31	118	15802	8483	34932528
Appendicitis	232.62	13.31	120	15800	14687	34926324
Cardiogenic shock	179.18	13.31	125	15795	26493	34914518
Stress	157.89	13.31	122	15798	30225	34910786
Blood phosphorus increased	146.03	13.31	71	15849	7650	34933361
Ventricular fibrillation	138.80	13.31	101	15819	22853	34918158
Hyponatraemia	136.75	13.31	178	15742	82513	34858498
Abdominal distension	136.36	13.31	150	15770	58342	34882669
Ascites	130.94	13.31	132	15788	46439	34894572
Sepsis	115.48	13.31	242	15678	166319	34774692
Respiratory depression	101.65	13.31	73	15847	16172	34924839
Victim of child abuse	98.36	13.31	30	15890	897	34940114
Multiple organ dysfunction syndrome	98.33	13.31	146	15774	76420	34864591
General physical health deterioration	93.06	13.31	190	15730	128079	34812932
Dry mouth	80.18	13.31	83	15837	30082	34910929
Epidural lipomatosis	78.29	13.31	26	15894	1028	34939983
Drug dependence	68.65	13.31	69	15851	24148	34916863
Abdominal pain	65.64	13.31	193	15727	163425	34777586
Juvenile idiopathic arthritis	63.40	13.31	26	15894	1871	34939140
Vomiting	61.59	13.31	249	15671	247372	34693639
Myasthenia gravis	59.70	13.31	38	15882	6902	34934109
Product prescribing error	55.43	13.31	60	15860	22867	34918144
Blood uric acid increased	55.10	13.31	41	15879	9583	34931428
Urinary tract infection	46.67	13.31	112	15808	83969	34857042
Constipation	46.01	13.31	152	15768	136830	34804181
Intestinal pseudo-obstruction	38.86	13.31	18	15902	1738	34939273
Drug therapy	35.97	13.31	15	15905	1126	34939885
Intentional product misuse	34.68	13.31	69	15851	45542	34895469
Analgesic therapy	34.45	13.31	14	15906	984	34940027
Somnolence	34.37	13.31	120	15800	110996	34830015
Hyperphosphataemia	32.56	13.31	22	15898	4415	34936596
Nausea	32.11	13.31	264	15656	339644	34601367
Sleep disorder therapy	30.75	13.31	13	15907	1010	34940001
Urosepsis	30.06	13.31	33	15887	12766	34928245
Incorrect route of product administration	29.33	13.31	35	15885	14810	34926201
Iron deficiency	28.75	13.31	22	15898	5359	34935652
Blood cholesterol increased	27.50	13.31	40	15880	20503	34920508
Neuralgia	25.63	13.31	33	15887	15080	34925931
Mixed dementia	25.30	13.31	8	15912	270	34940741
Obesity	24.85	13.31	30	15890	12848	34928163
Completed suicide	24.77	13.31	7	15913	98161	34842850
Sitting disability	23.35	13.31	7	15913	197	34940814
Urinary retention	18.68	13.31	47	15873	36241	34904770
Hypogonadism	18.53	13.31	12	15908	2243	34938768
Arthralgia	17.22	13.31	32	15888	170009	34771002
Cerebral hypoperfusion	16.89	13.31	7	15913	517	34940494
Quality of life decreased	16.37	13.31	14	15906	3987	34937024
Hypophosphataemia	15.53	13.31	22	15898	11004	34930007
Transcription medication error	15.35	13.31	5	15915	186	34940825
Burkholderia test positive	15.21	13.31	8	15912	1015	34939996
Child abuse	14.77	13.31	6	15914	421	34940590
Drug ineffective	14.39	13.31	136	15784	456615	34484396
Decubitus ulcer	14.38	13.31	19	15901	8902	34932109
Alveolar proteinosis	14.01	13.31	6	15914	481	34940530
Convulsive threshold lowered	13.44	13.31	6	15914	532	34940479

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sedation complication	459.47	12.60	195	35774	15474	79692945
Creatinine renal clearance decreased	404.67	12.60	189	35780	18813	79689606
Cognitive disorder	368.18	12.60	282	35687	69644	79638775
Orthostatic hypotension	366.87	12.60	258	35711	55906	79652513
Blood calcium decreased	333.82	12.60	197	35772	31622	79676797
Sedation	331.07	12.60	235	35734	51660	79656759
Appendicolith	286.27	12.60	117	35852	8434	79699985
Hypomania	272.44	12.60	109	35860	7435	79700984
Balance disorder	268.80	12.60	274	35695	98583	79609836
Jaundice cholestatic	242.57	12.60	113	35856	11171	79697248
Schizophrenia	209.01	12.60	113	35856	15327	79693092
Appendicitis	203.12	12.60	123	35846	20671	79687748
Depressed level of consciousness	168.89	12.60	213	35756	96439	79611980
Mobility decreased	154.16	12.60	230	35739	121945	79586474
Psychotic disorder	145.00	12.60	132	35837	41270	79667149
Cardiogenic shock	141.66	12.60	131	35838	41783	79666636
Constipation	138.50	12.60	357	35612	282693	79425726
Ascites	135.92	12.60	169	35800	75393	79633026
Blood phosphorus increased	129.73	12.60	72	35897	10275	79698144
Macular degeneration	129.17	12.60	74	35895	11222	79697197
Hyponatraemia	121.72	12.60	256	35713	177592	79530827
Fall	120.25	12.60	486	35483	487143	79221276
Ventricular fibrillation	120.11	12.60	106	35863	31820	79676599
Chronic sinusitis	119.40	12.60	74	35895	12952	79695467
Abdominal distension	112.33	12.60	197	35772	119453	79588966
Hypotension	107.02	12.60	437	35532	439880	79268539
Intestinal pseudo-obstruction	105.78	12.60	41	35928	2568	79705851
Cholelithiasis	104.81	12.60	124	35845	52540	79655879
Victim of child abuse	97.81	12.60	30	35939	923	79707496
Paraesthesia oral	97.74	12.60	78	35891	20393	79688026
Total lung capacity increased	96.33	12.60	37	35932	2261	79706158
Blood bilirubin increased	94.15	12.60	132	35837	66100	79642319
Hepatotoxicity	92.56	12.60	115	35854	51237	79657182
Procedural pain	89.55	12.60	78	35891	23006	79685413
Asthma-chronic obstructive pulmonary disease overlap syndrome	84.25	12.60	37	35932	3184	79705235
Vaginal flatulence	81.98	12.60	34	35935	2541	79705878
Sepsis	77.27	12.60	282	35687	269146	79439273
Epidural lipomatosis	74.63	12.60	26	35943	1202	79707217
Vomiting	74.43	12.60	534	35435	665294	79043125
Abdominal pain	73.67	12.60	359	35610	389210	79319209
Respiratory depression	72.12	12.60	75	35894	27555	79680864
Nausea	69.57	12.60	697	35272	956499	78751920
Stress	68.19	12.60	126	35843	79486	79628933
Multiple organ dysfunction syndrome	66.40	12.60	159	35810	120087	79588332
General physical health deterioration	61.90	12.60	267	35702	274971	79433448
Rheumatoid arthritis	59.52	12.60	11	35958	208459	79499960
Nasal polyps	58.13	12.60	38	35931	7289	79701130
Arthralgia	57.98	12.60	106	35863	571697	79136722
Multiple drug therapy	55.60	12.60	30	35939	4048	79704371
Proctitis	55.07	12.60	35	35934	6397	79702022
Female genital tract fistula	54.90	12.60	34	35935	5941	79702478
Joint swelling	53.42	12.60	32	35937	288614	79419805
Drug ineffective	52.87	12.60	280	35689	1080633	78627786
Completed suicide	51.79	12.60	23	35946	245744	79462675
Sarcoidosis	51.38	12.60	37	35932	8298	79700121
Vaginal discharge	50.34	12.60	35	35934	7428	79700991
Drug dependence	50.28	12.60	76	35893	40693	79667726
Alopecia	49.78	12.60	21	35948	231334	79477085
Blood uric acid increased	49.52	12.60	44	35925	13316	79695103
Bronchiectasis	46.67	12.60	54	35915	22332	79686087
Myasthenia gravis	46.20	12.60	38	35931	10361	79698058
Juvenile idiopathic arthritis	46.05	12.60	28	35941	4735	79703684
Arthropathy	45.20	12.60	12	35957	177099	79531320
Radiculopathy	45.09	12.60	35	35934	8789	79699630
Treatment failure	44.57	12.60	11	35958	170475	79537944
Nasopharyngitis	43.10	12.60	31	35938	253850	79454569
Urinary retention	42.79	12.60	85	35884	56545	79651874
Rhinitis allergic	42.70	12.60	39	35930	12230	79696189
Hypersensitivity	41.99	12.60	34	35935	262205	79446214
Maternal exposure during pregnancy	41.66	12.60	6	35963	136532	79571887
Systemic lupus erythematosus	40.22	12.60	4	35965	121145	79587274
Product prescribing error	39.72	12.60	72	35897	44741	79663678
Cardiac murmur	39.59	12.60	42	35927	15782	79692637
Pain	38.40	12.60	485	35484	703317	79005102
Chronic obstructive pulmonary disease	35.89	12.60	102	35867	85317	79623102
Drug therapy	35.36	12.60	15	35954	1186	79707233
Analgesic therapy	34.43	12.60	14	35955	995	79707424
Sinusitis	34.33	12.60	23	35946	195478	79512941
Pneumonia	34.31	12.60	451	35518	659795	79048624
Toxicity to various agents	32.87	12.60	312	35657	421228	79287191
Contraindicated product administered	32.77	12.60	15	35954	157523	79550896
Therapeutic product effect decreased	31.97	12.60	17	35952	163846	79544573
Intentional product misuse	31.90	12.60	105	35864	95060	79613359
Sleep disorder therapy	30.85	12.60	13	35956	1011	79707408
Rash	30.31	12.60	146	35823	578212	79130207
Pain in extremity	29.88	12.60	76	35893	364462	79343957
Hyperphosphataemia	29.80	12.60	24	35945	6352	79702067
Urinary tract infection	29.26	12.60	218	35751	274294	79434125
Pericarditis	28.69	12.60	6	35963	104230	79604189
Peripheral swelling	26.36	12.60	51	35918	269566	79438853
Dry mouth	25.90	12.60	93	35876	87926	79620493
Drug intolerance	25.79	12.60	50	35919	264069	79444350
Frequent bowel movements	25.59	12.60	47	35922	29492	79678927
Exposure during pregnancy	25.52	12.60	7	35962	101125	79607294
Total lung capacity decreased	25.35	12.60	16	35953	2889	79705530
Mixed dementia	25.01	12.60	8	35961	283	79708136
Wound	24.26	12.60	11	35958	116168	79592251
Atonic urinary bladder	24.22	12.60	6	35963	81	79708338
Injection site pain	23.16	12.60	15	35954	129823	79578596
Interstitial lung disease	22.98	12.60	11	35958	112589	79595830
Bronchopulmonary aspergillosis allergic	22.17	12.60	15	35954	3046	79705373
Diarrhoea	22.03	12.60	273	35696	880216	78828203
Death	21.93	12.60	368	35601	566146	79142273
Abdominal discomfort	21.53	12.60	51	35918	250676	79457743
Quality of life decreased	21.49	12.60	25	35944	10395	79698024
Hypogonadism	21.39	12.60	12	35957	1748	79706671
Arthritis	20.86	12.60	13	35956	114867	79593552
Oral candidiasis	20.63	12.60	43	35926	29585	79678834
Fatigue	20.46	12.60	296	35673	929431	78778988
Therapy non-responder	20.45	12.60	8	35961	92297	79616122
Dyspepsia	19.64	12.60	99	35870	108588	79599831
Psoriasis	19.47	12.60	8	35961	89579	79618840
Iron deficiency	19.41	12.60	24	35945	10630	79697789
Lung opacity	19.09	12.60	17	35952	5157	79703262
Urosepsis	19.09	12.60	39	35930	26456	79681963
Sitting disability	18.84	12.60	7	35962	390	79708029
Loss of bladder sensation	18.54	12.60	5	35964	96	79708323
Small intestinal obstruction	18.31	12.60	39	35930	27233	79681186
Therapeutic response decreased	18.08	12.60	4	35965	66849	79641570
Colitis ischaemic	18.04	12.60	28	35941	15331	79693088
Inflammation	17.88	12.60	10	35959	93743	79614676
Decubitus ulcer	17.60	12.60	28	35941	15659	79692760
Gastrointestinal disorder	17.00	12.60	18	35951	122187	79586232
Weight increased	16.95	12.60	66	35903	277320	79431099
Cough	16.72	12.60	97	35872	366692	79341727
Lung neoplasm malignant	16.69	12.60	38	35931	27754	79680665
Hypoxia	16.56	12.60	91	35878	103152	79605267
Body dysmorphic disorder	16.42	12.60	6	35963	319	79708100
Reduced facial expression	16.42	12.60	12	35957	2753	79705666
Lung disorder	16.24	12.60	8	35961	80549	79627870
Somnolence	16.22	12.60	172	35797	238809	79469610
Anal sphincter atony	16.19	12.60	6	35963	332	79708087
Visual impairment	15.95	12.60	11	35958	92120	79616299
Foreign body	15.93	12.60	12	35957	2882	79705537
Neurogenic bladder	15.86	12.60	14	35955	4198	79704221
Impaired healing	15.80	12.60	10	35959	87645	79620774
Hypophosphataemia	15.17	12.60	30	35939	19883	79688536
Mental status changes	15.04	12.60	65	35904	66894	79641525
Colitis	14.84	12.60	69	35900	73238	79635181
Child abuse	14.80	12.60	6	35963	423	79707996
Unresponsive to stimuli	14.78	12.60	57	35912	55731	79652688
Transcription medication error	14.54	12.60	6	35963	443	79707976
Neuralgia	14.15	12.60	40	35929	33344	79675075
Injection site erythema	13.99	12.60	9	35960	78188	79630231
Functional gastrointestinal disorder	13.84	12.60	14	35955	4976	79703443
Infection	13.83	12.60	59	35910	241653	79466766
Headache	13.36	12.60	211	35758	653561	79054858
Flatulence	13.30	12.60	46	35923	42678	79665741
Intentional product use issue	13.00	12.60	31	35938	152081	79556338
Freezing phenomenon	12.96	12.60	9	35960	1905	79706514
Listless	12.91	12.60	12	35957	3849	79704570
Leukocytosis	12.85	12.60	46	35923	43409	79665010
Urticaria	12.68	12.60	42	35927	185159	79523260
Ill-defined disorder	12.60	12.60	7	35962	65868	79642551

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A06AB02	ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Contact laxatives
ATC	A06AB52	ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Contact laxatives
ATC	A06AG02	ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Enemas
FDA PE	N0000009371	Increased Large Intestinal Motility
FDA PE	N0000009871	Stimulation Large Intestine Fluid/Electrolyte Secretion
MeSH PA	D002400	Cathartics
MeSH PA	D005765	Gastrointestinal Agents
MeSH PA	D054368	Laxatives
FDA EPC	N0000175812	Stimulant Laxative

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Constipation	indication	14760008	DOID:2089
Incomplete passage of stool	indication	249515001
Anuria	contraindication	2472002	DOID:2983
Hypocalcemia	contraindication	5291005
Rectal hemorrhage	contraindication	12063002
Hyperkalemia	contraindication	14140009
Severe chronic ulcerative colitis	contraindication	14311001
Acute vomiting	contraindication	23971007
Complete atrioventricular block	contraindication	27885002
Toxic megacolon	contraindication	28536002	DOID:1770
Anal fissure	contraindication	30037006
Gastrointestinal ulcer	contraindication	40845000
Toxic colitis	contraindication	42359007
Hypokalemia	contraindication	43339004
Chronic heart failure	contraindication	48447003
Gastrointestinal perforation	contraindication	51875005
Chronic ulcerative proctitis	contraindication	52231000
Congenital myotonia, autosomal dominant form	contraindication	57938005
Acute nephropathy	contraindication	58574008
Incontinence of feces	contraindication	72042002
Appendicitis	contraindication	74400008	DOID:8337
Hyperchloremia	contraindication	74450001
Third degree burn injury	contraindication	80247002
Intestinal obstruction	contraindication	81060008	DOID:8437
Oliguria	contraindication	83128009
Hyponatremia	contraindication	89627008
Kidney disease	contraindication	90708001	DOID:557
Gastrointestinal obstruction	contraindication	126765001
Seizure disorder	contraindication	128613002
Hyporeninemic hypoaldosteronism	contraindication	236464008
Edema	contraindication	267038008
Familial hyperkalemic periodic paralysis	contraindication	304737009	DOID:14451
Gastric retention	contraindication	307227006
At risk for aspiration	contraindication	371736008
Severe dehydration	contraindication	450316000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.39	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN	Ki	5.76	DRUG MATRIX
Kappa-type opioid receptor	GPCR	P41145	OPRK_HUMAN	Ki	6.01	DRUG MATRIX
Cytochrome P450 2C9	Enzyme	P11712	CP2C9_HUMAN	IC50	5	DRUG MATRIX

External reference:

ID	Source
4018526	VUID
N0000146848	NUI
D00245	KEGG_DRUG
151672	RXNORM
C0005632	UMLSCUI
CHEBI:3125	CHEBI
CHEMBL942	ChEMBL_ID
DB09020	DRUGBANK_ID
D001726	MESH_DESCRIPTOR_UI
2391	PUBCHEM_CID
824	INN_ID
10X0709Y6I	UNII
4286	MMSL
4855	MMSL
d01015	MMSL
13565005	SNOMEDCT_US
387075009	SNOMEDCT_US
4018526	VANDF
001172	NDDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Fleet	HUMAN OTC DRUG LABEL	1	0132-0703	ENEMA	10 mg	RECTAL	OTC monograph not final	11 sections
Gentle Laxative	HUMAN OTC DRUG LABEL	1	0363-0327	TABLET	5 mg	ORAL	OTC MONOGRAPH NOT FINAL	16 sections
Gentle Laxative	HUMAN OTC DRUG LABEL	1	0363-0327	TABLET	5 mg	ORAL	OTC MONOGRAPH NOT FINAL	16 sections
Gentle Laxative	HUMAN OTC DRUG LABEL	1	0363-0327	TABLET	5 mg	ORAL	OTC MONOGRAPH NOT FINAL	16 sections
Walgreens Gentle Laxative	HUMAN OTC DRUG LABEL	1	0363-0466	SUPPOSITORY	10 mg	RECTAL	OTC monograph not final	14 sections
Walgreens Gentle Laxative	HUMAN OTC DRUG LABEL	1	0363-0466	SUPPOSITORY	10 mg	RECTAL	OTC monograph not final	14 sections
Walgreens Gentle Laxative	HUMAN OTC DRUG LABEL	1	0363-0466	SUPPOSITORY	10 mg	RECTAL	OTC monograph not final	14 sections
Walgreens Gentle Laxative	HUMAN OTC DRUG LABEL	1	0363-0466	SUPPOSITORY	10 mg	RECTAL	OTC monograph not final	14 sections
Walgreens Gentle Laxative	HUMAN OTC DRUG LABEL	1	0363-0466	SUPPOSITORY	10 mg	RECTAL	OTC monograph not final	14 sections
Walgreens Gentle Laxative	HUMAN OTC DRUG LABEL	1	0363-0466	SUPPOSITORY	10 mg	RECTAL	OTC monograph not final	14 sections
WOMENS GENTLE LAXATIVE	HUMAN OTC DRUG LABEL	1	0363-3011	CAPSULE, GELATIN COATED	5 mg	ORAL	OTC monograph not final	16 sections
WOMENS GENTLE LAXATIVE	HUMAN OTC DRUG LABEL	1	0363-3011	CAPSULE, GELATIN COATED	5 mg	ORAL	OTC monograph not final	16 sections
Laxative	HUMAN OTC DRUG LABEL	1	0363-6760	TABLET, COATED	5 mg	ORAL	OTC monograph not final	15 sections
Laxative	HUMAN OTC DRUG LABEL	1	0363-6760	TABLET, COATED	5 mg	ORAL	OTC monograph not final	15 sections
Rugby Gentle Laxative	HUMAN OTC DRUG LABEL	1	0536-1238	SUPPOSITORY	10 mg	RECTAL	OTC monograph not final	15 sections
ENTERIC COATED STIMULANT LAXATIVE	HUMAN OTC DRUG LABEL	1	0536-3381	TABLET, DELAYED RELEASE	5 mg	ORAL	OTC monograph not final	6 sections
Bisacodyl	HUMAN OTC DRUG LABEL	1	0574-7050	SUPPOSITORY	10 mg	RECTAL	OTC monograph not final	15 sections
Bisacodyl	HUMAN OTC DRUG LABEL	1	0615-0598	TABLET, COATED	5 mg	ORAL	OTC MONOGRAPH NOT FINAL	14 sections
Unit Dose Bisacodyl	HUMAN OTC DRUG LABEL	1	0904-6407	TABLET, DELAYED RELEASE	5 mg	ORAL	OTC monograph not final	15 sections
Unit Dose Bisacodyl	HUMAN OTC DRUG LABEL	1	0904-6407	TABLET, DELAYED RELEASE	5 mg	ORAL	OTC monograph not final	15 sections
Bisacodyl	HUMAN OTC DRUG LABEL	1	0904-6748	TABLET, COATED	5 mg	ORAL	OTC monograph not final	15 sections
Bisacodyl	HUMAN OTC DRUG LABEL	1	0904-6748	TABLET, COATED	5 mg	ORAL	OTC monograph not final	15 sections
Bisacodyl	HUMAN OTC DRUG LABEL	1	0904-6748	TABLET, COATED	5 mg	ORAL	OTC monograph not final	15 sections
Leader Gentle Laxative	HUMAN OTC DRUG LABEL	1	0904-6981	SUPPOSITORY	10 mg	RECTAL	OTC monograph not final	15 sections
Leader Gentle Laxative	HUMAN OTC DRUG LABEL	1	0904-6981	SUPPOSITORY	10 mg	RECTAL	OTC monograph not final	15 sections
Bisacodyl	HUMAN OTC DRUG LABEL	1	0904-7142	SUPPOSITORY	10 mg	RECTAL	OTC monograph not final	14 sections
Bisacodyl	HUMAN OTC DRUG LABEL	1	0904-7142	SUPPOSITORY	10 mg	RECTAL	OTC monograph not final	14 sections
Carters Little PillsSodium-Free	HUMAN OTC DRUG LABEL	1	10237-906	TABLET, DELAYED RELEASE	5 mg	ORAL	OTC monograph not final	11 sections
Carters Little PillsSodium-Free	HUMAN OTC DRUG LABEL	1	10237-906	TABLET, DELAYED RELEASE	5 mg	ORAL	OTC monograph not final	11 sections
Bisacodyl	HUMAN OTC DRUG LABEL	1	11534-013	TABLET, DELAYED RELEASE	5 mg	ORAL	OTC monograph not final	13 sections