bifonazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| systemic antifungal agents, miconazole derivatives | 370 | 60628-96-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D01AC10 | DERMATOLOGICALS ANTIFUNGALS FOR DERMATOLOGICAL USE ANTIFUNGALS FOR TOPICAL USE Imidazole and triazole derivatives |
| ATC | D01AC60 | DERMATOLOGICALS ANTIFUNGALS FOR DERMATOLOGICAL USE ANTIFUNGALS FOR TOPICAL USE Imidazole and triazole derivatives |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000935 | Antifungal Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 5.84 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Cytochrome P450 3A4 | Enzyme | IC50 | 6.10 | CHEMBL | |||||
| Steroid 17-alpha-hydroxylase/17,20 lyase | Enzyme | Ki | 7.25 | CHEMBL | |||||
| Lanosterol 14-alpha demethylase | Enzyme | IC50 | 6.47 | CHEMBL | |||||
| Indoleamine 2,3-dioxygenase 1 | Enzyme | IC50 | 4.64 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01775 | KEGG_DRUG |
| 19295 | RXNORM |
| C0053570 | UMLSCUI |
| CHEBI:31286 | CHEBI |
| TMI | PDB_CHEM_ID |
| CHEMBL277535 | ChEMBL_ID |
| DB04794 | DRUGBANK_ID |
| C036596 | MESH_SUPPLEMENTAL_RECORD_UI |
| 2378 | PUBCHEM_CID |
| 4887 | INN_ID |
| QYJ305Z91O | UNII |
| 136216003 | SNOMEDCT_US |
| 396036005 | SNOMEDCT_US |
| 004316 | NDDF |
Pharmaceutical products:
None