bifemelane 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 369 | 90293-01-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 13 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N06AX08 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Other antidepressants |
| MeSH PA | D000928 | Antidepressive Agents |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D011619 | Psychotropic Drugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Cerebrovascular disease | indication | 62914000 | DOID:6713 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.48 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Amine oxidase [flavin-containing] B | Enzyme | INHIBITOR | Ki | 4.34 | IUPHAR | ||||
| Amine oxidase [flavin-containing] A | Enzyme | INHIBITOR | Ki | 5.38 | IUPHAR | ||||
| Lethal(3)malignant brain tumor-like protein 1 | Unclassified | IC50 | 4.04 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01793 | KEGG_DRUG |
| 62232-46-6 | SECONDARY_CAS_RN |
| 47111 | RXNORM |
| C0106291 | UMLSCUI |
| CHEBI:92338 | CHEBI |
| CHEMBL1192517 | ChEMBL_ID |
| DB13550 | DRUGBANK_ID |
| C031906 | MESH_SUPPLEMENTAL_RECORD_UI |
| 2377 | PUBCHEM_CID |
| 11742 | IUPHAR_LIGAND_ID |
| 5902 | INN_ID |
| Z4501GN13G | UNII |
| 006415 | NDDF |
| 006416 | NDDF |
Pharmaceutical products:
None