vorozole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
aromatase inhibitors, imidazole-triazole derivatives 3651 129731-10-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • R-83842
  • R83842
  • vorozole
  • rivizor
  • (+)-Vorozole
  • Molecular weight: 324.77
  • Formula: C16H13ClN6
  • CLOGP: 2.47
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 0
  • TPSA: 61.42
  • ALOGS: -3.20
  • ROTB: 3

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 8 % Benet LZ, Broccatelli F, Oprea TI

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L02BG05 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ENDOCRINE THERAPY
HORMONE ANTAGONISTS AND RELATED AGENTS
Aromatase inhibitors
MeSH PA D000970 Antineoplastic Agents
MeSH PA D047072 Aromatase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D004965 Estrogen Antagonists
MeSH PA D006727 Hormone Antagonists
MeSH PA D065088 Steroid Synthesis Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.04 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Aromatase Enzyme INHIBITOR IC50 8.86 CHEMBL SCIENTIFIC LITERATURE

External reference:

IDSource
D03786 KEGG_DRUG
C0286224 UMLSCUI
CHEBI:135387 CHEBI
CHEMBL224060 ChEMBL_ID
DB13767 DRUGBANK_ID
C060523 MESH_SUPPLEMENTAL_RECORD_UI
6918191 PUBCHEM_CID
6477 INN_ID
1E2S9YXV2A UNII

Pharmaceutical products:

None