anastrozole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| aromatase inhibitors, imidazole-triazole derivatives | 210 | 120511-73-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A nitrile and triazole derivative that acts as a selective nonsteroidal aromatase inhibitor. It is used in the treatment of ESTROGEN NUCLEAR RECEPTOR-positive breast cancer in postmenopausal women.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 0.50 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 10 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.06 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 80 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 27, 1995 | FDA | ASTRAZENECA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Metastases to bone | 950.77 | 11.36 | 410 | 43113 | 17585 | 50544016 |
| Malignant neoplasm progression | 700.60 | 11.36 | 531 | 42992 | 67593 | 50494008 |
| Metastases to liver | 509.43 | 11.36 | 277 | 43246 | 19827 | 50541774 |
| Metastases to lung | 404.56 | 11.36 | 195 | 43328 | 10825 | 50550776 |
| Osteonecrosis | 341.78 | 11.36 | 223 | 43300 | 22294 | 50539307 |
| Hot flush | 292.24 | 11.36 | 267 | 43256 | 43902 | 50517699 |
| Breast cancer recurrent | 255.57 | 11.36 | 103 | 43420 | 3705 | 50557896 |
| Breast cancer metastatic | 249.18 | 11.36 | 138 | 43385 | 10226 | 50551375 |
| Bone pain | 230.98 | 11.36 | 242 | 43281 | 46987 | 50514614 |
| Drug ineffective | 218.64 | 11.36 | 231 | 43292 | 819102 | 49742499 |
| Disease progression | 208.06 | 11.36 | 328 | 43195 | 95538 | 50466063 |
| Metastases to lymph nodes | 206.70 | 11.36 | 107 | 43416 | 6917 | 50554684 |
| Breast cancer | 203.02 | 11.36 | 216 | 43307 | 42674 | 50518927 |
| Neoplasm progression | 180.68 | 11.36 | 170 | 43353 | 28987 | 50532614 |
| Osteonecrosis of jaw | 161.37 | 11.36 | 168 | 43355 | 32358 | 50529243 |
| Neutropenia | 157.15 | 11.36 | 374 | 43149 | 147591 | 50414010 |
| Tumour marker increased | 153.26 | 11.36 | 72 | 43451 | 3768 | 50557833 |
| Tooth extraction | 135.50 | 11.36 | 89 | 43434 | 8986 | 50552615 |
| Ejection fraction decreased | 128.38 | 11.36 | 115 | 43408 | 18405 | 50543196 |
| Maternal exposure during pregnancy | 123.15 | 11.36 | 3 | 43520 | 159775 | 50401826 |
| Arthralgia | 121.33 | 11.36 | 716 | 42807 | 437986 | 50123615 |
| Pseudocirrhosis | 115.62 | 11.36 | 36 | 43487 | 594 | 50561007 |
| Metastases to spine | 106.60 | 11.36 | 51 | 43472 | 2780 | 50558821 |
| Metastasis | 101.72 | 11.36 | 57 | 43466 | 4318 | 50557283 |
| Systemic lupus erythematosus | 91.36 | 11.36 | 8 | 43515 | 140614 | 50420987 |
| Bone lesion | 90.34 | 11.36 | 56 | 43467 | 5114 | 50556487 |
| Infusion related reaction | 88.29 | 11.36 | 19 | 43504 | 169538 | 50392063 |
| Carbohydrate antigen 15-3 increased | 87.79 | 11.36 | 34 | 43489 | 1098 | 50560503 |
| Trigger finger | 87.11 | 11.36 | 49 | 43474 | 3739 | 50557862 |
| White blood cell count decreased | 86.21 | 11.36 | 258 | 43265 | 116464 | 50445137 |
| Therapeutic product effect decreased | 85.06 | 11.36 | 9 | 43514 | 136041 | 50425560 |
| Osteopenia | 82.77 | 11.36 | 87 | 43436 | 16931 | 50544670 |
| Completed suicide | 81.75 | 11.36 | 9 | 43514 | 131880 | 50429721 |
| Bone disorder | 80.93 | 11.36 | 90 | 43433 | 18662 | 50542939 |
| Vitreoretinal traction syndrome | 78.77 | 11.36 | 13 | 43510 | 0 | 50561601 |
| Synovitis | 77.93 | 11.36 | 8 | 43515 | 123857 | 50437744 |
| Osteolysis | 75.36 | 11.36 | 39 | 43484 | 2518 | 50559083 |
| Treatment failure | 74.61 | 11.36 | 14 | 43509 | 137623 | 50423978 |
| Rheumatoid arthritis | 74.10 | 11.36 | 41 | 43482 | 202509 | 50359092 |
| Neuropathy peripheral | 69.66 | 11.36 | 212 | 43311 | 96545 | 50465056 |
| Acute myeloid leukaemia | 64.45 | 11.36 | 72 | 43451 | 15002 | 50546599 |
| Tonsillar disorder | 62.66 | 11.36 | 26 | 43497 | 1008 | 50560593 |
| Organising pneumonia | 62.12 | 11.36 | 43 | 43480 | 4731 | 50556870 |
| Joint swelling | 61.78 | 11.36 | 72 | 43451 | 245214 | 50316387 |
| Breast cancer female | 60.64 | 11.36 | 49 | 43474 | 6813 | 50554788 |
| Myalgia | 56.38 | 11.36 | 234 | 43289 | 124085 | 50437516 |
| Nasal disorder | 56.19 | 11.36 | 31 | 43492 | 2277 | 50559324 |
| Retinal toxicity | 55.96 | 11.36 | 25 | 43498 | 1163 | 50560438 |
| Malignant pleural effusion | 55.92 | 11.36 | 31 | 43492 | 2299 | 50559302 |
| Pain in jaw | 55.39 | 11.36 | 110 | 43413 | 38318 | 50523283 |
| Cystoid macular oedema | 55.11 | 11.36 | 26 | 43497 | 1373 | 50560228 |
| Ascites | 54.54 | 11.36 | 105 | 43418 | 35756 | 50525845 |
| Sequestrectomy | 54.50 | 11.36 | 22 | 43501 | 794 | 50560807 |
| Metastases to pleura | 53.70 | 11.36 | 25 | 43498 | 1281 | 50560320 |
| Debridement | 52.96 | 11.36 | 24 | 43499 | 1155 | 50560446 |
| Lacrimation increased | 52.75 | 11.36 | 69 | 43454 | 16923 | 50544678 |
| Glossodynia | 52.45 | 11.36 | 17 | 43506 | 115552 | 50446049 |
| Lymphoedema | 52.33 | 11.36 | 51 | 43472 | 9071 | 50552530 |
| Drug hypersensitivity | 50.92 | 11.36 | 86 | 43437 | 250924 | 50310677 |
| Metastases to central nervous system | 50.15 | 11.36 | 55 | 43468 | 11227 | 50550374 |
| Toxicity to various agents | 47.68 | 11.36 | 68 | 43455 | 212431 | 50349170 |
| Hypersensitivity | 47.15 | 11.36 | 70 | 43453 | 215091 | 50346510 |
| Metastases to the mediastinum | 46.97 | 11.36 | 17 | 43506 | 453 | 50561148 |
| Osteomyelitis | 46.36 | 11.36 | 75 | 43448 | 22278 | 50539323 |
| Invasive ductal breast carcinoma | 45.50 | 11.36 | 39 | 43484 | 5882 | 50555719 |
| Pericarditis | 44.84 | 11.36 | 7 | 43516 | 78682 | 50482919 |
| PIK3CA-activated mutation | 44.51 | 11.36 | 19 | 43504 | 791 | 50560810 |
| Fatigue | 44.28 | 11.36 | 853 | 42670 | 706748 | 49854853 |
| Peritoneal disorder | 44.01 | 11.36 | 16 | 43507 | 432 | 50561169 |
| Bone sequestrum | 43.46 | 11.36 | 22 | 43501 | 1356 | 50560245 |
| Metastases to pelvis | 43.32 | 11.36 | 15 | 43508 | 350 | 50561251 |
| Endometrial hyperplasia | 42.75 | 11.36 | 18 | 43505 | 724 | 50560877 |
| Abdominal discomfort | 41.12 | 11.36 | 86 | 43437 | 231555 | 50330046 |
| Wound | 40.75 | 11.36 | 20 | 43503 | 105774 | 50455827 |
| Interstitial lung disease | 39.64 | 11.36 | 118 | 43405 | 53058 | 50508543 |
| Vulvovaginal dryness | 38.70 | 11.36 | 24 | 43499 | 2193 | 50559408 |
| Oestradiol increased | 38.69 | 11.36 | 10 | 43513 | 80 | 50561521 |
| Hair growth abnormal | 37.94 | 11.36 | 25 | 43498 | 2536 | 50559065 |
| Hypotension | 37.28 | 11.36 | 93 | 43430 | 235376 | 50326225 |
| Pleural neoplasm | 36.91 | 11.36 | 12 | 43511 | 229 | 50561372 |
| Intentional overdose | 36.91 | 11.36 | 5 | 43518 | 62499 | 50499102 |
| Pathological fracture | 36.86 | 11.36 | 39 | 43484 | 7643 | 50553958 |
| Nail disorder | 35.84 | 11.36 | 43 | 43480 | 9665 | 50551936 |
| Pleural effusion | 35.10 | 11.36 | 151 | 43372 | 81303 | 50480298 |
| Off label use | 34.39 | 11.36 | 253 | 43270 | 474173 | 50087428 |
| Hypertensive angiopathy | 33.88 | 11.36 | 9 | 43514 | 81 | 50561520 |
| Metastatic neoplasm | 33.58 | 11.36 | 27 | 43496 | 3727 | 50557874 |
| Oestrogen receptor assay positive | 33.27 | 11.36 | 13 | 43510 | 430 | 50561171 |
| Second primary malignancy | 33.00 | 11.36 | 35 | 43488 | 6879 | 50554722 |
| Leukopenia | 32.89 | 11.36 | 130 | 43393 | 67398 | 50494203 |
| Carpal tunnel syndrome | 32.76 | 11.36 | 55 | 43468 | 16838 | 50544763 |
| Metastases to chest wall | 32.31 | 11.36 | 13 | 43510 | 465 | 50561136 |
| Sialoadenitis | 31.89 | 11.36 | 18 | 43505 | 1382 | 50560219 |
| Tendonitis | 31.88 | 11.36 | 54 | 43469 | 16651 | 50544950 |
| Sinusitis | 31.38 | 11.36 | 62 | 43461 | 170496 | 50391105 |
| Injection site erythema | 30.67 | 11.36 | 13 | 43510 | 74923 | 50486678 |
| Uterine polyp | 30.51 | 11.36 | 19 | 43504 | 1749 | 50559852 |
| Pancreatic neoplasm | 30.47 | 11.36 | 14 | 43509 | 696 | 50560905 |
| Intentional product use issue | 30.44 | 11.36 | 14 | 43509 | 76904 | 50484697 |
| Thrombocytopenia | 30.43 | 11.36 | 201 | 43322 | 127472 | 50434129 |
| Product substitution issue | 30.29 | 11.36 | 48 | 43475 | 14009 | 50547592 |
| Arthropathy | 30.27 | 11.36 | 56 | 43467 | 157850 | 50403751 |
| Dental care | 29.74 | 11.36 | 15 | 43508 | 917 | 50560684 |
| Palmar-plantar erythrodysaesthesia syndrome | 29.52 | 11.36 | 58 | 43465 | 20040 | 50541561 |
| Metastases to soft tissue | 28.76 | 11.36 | 9 | 43514 | 151 | 50561450 |
| Injection site pain | 28.55 | 11.36 | 32 | 43491 | 110992 | 50450609 |
| Acute phase reaction | 28.34 | 11.36 | 10 | 43513 | 247 | 50561354 |
| Swelling | 28.28 | 11.36 | 84 | 43439 | 200788 | 50360813 |
| Joint stiffness | 28.27 | 11.36 | 73 | 43450 | 30235 | 50531366 |
| Gingivitis | 28.11 | 11.36 | 33 | 43490 | 7251 | 50554350 |
| Musculoskeletal chest pain | 27.94 | 11.36 | 54 | 43469 | 18432 | 50543169 |
| Vitreous detachment | 27.77 | 11.36 | 18 | 43505 | 1776 | 50559825 |
| Chronic inflammatory demyelinating polyradiculoneuropathy | 27.76 | 11.36 | 11 | 43512 | 378 | 50561223 |
| Dry skin | 27.72 | 11.36 | 91 | 43432 | 43100 | 50518501 |
| Injection site reaction | 27.28 | 11.36 | 5 | 43518 | 50027 | 50511574 |
| Tooth loss | 27.28 | 11.36 | 30 | 43493 | 6140 | 50555461 |
| Metastases to skin | 26.78 | 11.36 | 16 | 43507 | 1367 | 50560234 |
| Progesterone receptor assay positive | 26.77 | 11.36 | 10 | 43513 | 292 | 50561309 |
| Metastases to peritoneum | 26.67 | 11.36 | 21 | 43502 | 2812 | 50558789 |
| Human epidermal growth factor receptor negative | 26.36 | 11.36 | 5 | 43518 | 6 | 50561595 |
| Irritable bowel syndrome | 26.27 | 11.36 | 6 | 43517 | 51435 | 50510166 |
| Fibrous histiocytoma | 26.00 | 11.36 | 11 | 43512 | 448 | 50561153 |
| Metastases to thorax | 25.79 | 11.36 | 9 | 43514 | 215 | 50561386 |
| Breast pain | 25.56 | 11.36 | 32 | 43491 | 7512 | 50554089 |
| Superinfection | 25.54 | 11.36 | 18 | 43505 | 2038 | 50559563 |
| Bone density decreased | 25.51 | 11.36 | 39 | 43484 | 11036 | 50550565 |
| Periodontal disease | 25.48 | 11.36 | 16 | 43507 | 1494 | 50560107 |
| Pneumonia | 25.40 | 11.36 | 206 | 43317 | 378195 | 50183406 |
| Hormone receptor positive breast cancer | 25.39 | 11.36 | 11 | 43512 | 475 | 50561126 |
| Portal hypertension | 25.37 | 11.36 | 22 | 43501 | 3370 | 50558231 |
| Dysgeusia | 24.98 | 11.36 | 82 | 43441 | 38834 | 50522767 |
| Radiation skin injury | 24.96 | 11.36 | 13 | 43510 | 850 | 50560751 |
| Discomfort | 24.96 | 11.36 | 34 | 43489 | 108346 | 50453255 |
| Exposed bone in jaw | 24.75 | 11.36 | 20 | 43503 | 2780 | 50558821 |
| Condition aggravated | 24.68 | 11.36 | 152 | 43371 | 296906 | 50264695 |
| Metastases to retroperitoneum | 24.59 | 11.36 | 8 | 43515 | 153 | 50561448 |
| Product use issue | 24.45 | 11.36 | 58 | 43465 | 149417 | 50412184 |
| Injection site pruritus | 24.42 | 11.36 | 3 | 43520 | 40408 | 50521193 |
| Polyneuropathy | 24.20 | 11.36 | 40 | 43483 | 12091 | 50549510 |
| Metastases to abdominal wall | 24.16 | 11.36 | 7 | 43516 | 89 | 50561512 |
| Recall phenomenon | 23.97 | 11.36 | 11 | 43512 | 545 | 50561056 |
| Therapeutic product effect incomplete | 23.94 | 11.36 | 26 | 43497 | 91489 | 50470112 |
| Drug intolerance | 23.92 | 11.36 | 102 | 43421 | 219002 | 50342599 |
| Excessive eye blinking | 23.84 | 11.36 | 13 | 43510 | 933 | 50560668 |
| Recurrent cancer | 23.27 | 11.36 | 16 | 43507 | 1741 | 50559860 |
| Tooth disorder | 23.26 | 11.36 | 59 | 43464 | 24169 | 50537432 |
| Fracture | 22.84 | 11.36 | 47 | 43476 | 16786 | 50544815 |
| Retinal detachment | 22.78 | 11.36 | 25 | 43498 | 5104 | 50556497 |
| Cutaneous vasculitis | 22.46 | 11.36 | 23 | 43500 | 4339 | 50557262 |
| Overdose | 22.25 | 11.36 | 32 | 43491 | 99695 | 50461906 |
| Hepatic lesion | 22.23 | 11.36 | 22 | 43501 | 3986 | 50557615 |
| Antisynthetase syndrome | 22.20 | 11.36 | 6 | 43517 | 58 | 50561543 |
| Tumour marker decreased | 22.20 | 11.36 | 6 | 43517 | 58 | 50561543 |
| Haemorrhoids | 22.18 | 11.36 | 50 | 43473 | 19003 | 50542598 |
| Muscle injury | 21.83 | 11.36 | 3 | 43520 | 37108 | 50524493 |
| Loss of personal independence in daily activities | 21.76 | 11.36 | 17 | 43506 | 70033 | 50491568 |
| Bone debridement | 21.47 | 11.36 | 8 | 43515 | 232 | 50561369 |
| Autoimmune pancreatitis | 21.37 | 11.36 | 8 | 43515 | 235 | 50561366 |
| Folliculitis | 21.22 | 11.36 | 4 | 43519 | 39221 | 50522380 |
| Psoriatic arthropathy | 21.18 | 11.36 | 7 | 43516 | 47025 | 50514576 |
| Osteosclerosis | 21.05 | 11.36 | 20 | 43503 | 3447 | 50558154 |
| Ischaemic stroke | 21.01 | 11.36 | 44 | 43479 | 15904 | 50545697 |
| Vertebral column mass | 21.00 | 11.36 | 7 | 43516 | 145 | 50561456 |
| Neoplasm malignant | 20.97 | 11.36 | 56 | 43467 | 23659 | 50537942 |
| Vascular purpura | 20.83 | 11.36 | 13 | 43510 | 1201 | 50560400 |
| Osteoporosis | 20.73 | 11.36 | 85 | 43438 | 44794 | 50516807 |
| Cardiomyopathy | 20.54 | 11.36 | 43 | 43480 | 15543 | 50546058 |
| Jaw operation | 20.44 | 11.36 | 11 | 43512 | 769 | 50560832 |
| Henoch-Schonlein purpura | 20.40 | 11.36 | 12 | 43511 | 996 | 50560605 |
| Anaphylactic reaction | 19.65 | 11.36 | 11 | 43512 | 54044 | 50507557 |
| Blood copper increased | 19.53 | 11.36 | 4 | 43519 | 9 | 50561592 |
| Cholestasis | 19.53 | 11.36 | 57 | 43466 | 25344 | 50536257 |
| Papilloedema | 19.14 | 11.36 | 19 | 43504 | 3454 | 50558147 |
| Transient acantholytic dermatosis | 19.13 | 11.36 | 5 | 43518 | 42 | 50561559 |
| Neoplasm recurrence | 19.01 | 11.36 | 16 | 43507 | 2353 | 50559248 |
| Mouth swelling | 19 | 11.36 | 20 | 43503 | 3896 | 50557705 |
| Pain | 18.84 | 11.36 | 368 | 43155 | 578535 | 49983066 |
| Gastrointestinal disorder | 18.54 | 11.36 | 33 | 43490 | 94423 | 50467178 |
| Carcinoembryonic antigen increased | 18.53 | 11.36 | 13 | 43510 | 1461 | 50560140 |
| Jaw disorder | 18.42 | 11.36 | 22 | 43501 | 4921 | 50556680 |
| Carbohydrate antigen 27.29 increased | 18.35 | 11.36 | 5 | 43518 | 50 | 50561551 |
| Hepatic enzyme increased | 18.22 | 11.36 | 59 | 43464 | 137321 | 50424280 |
| Suicide attempt | 18.13 | 11.36 | 11 | 43512 | 51721 | 50509880 |
| Blood alkaline phosphatase increased | 18.07 | 11.36 | 72 | 43451 | 37454 | 50524147 |
| Autoimmune hepatitis | 18.06 | 11.36 | 27 | 43496 | 7492 | 50554109 |
| Borrelia infection | 17.87 | 11.36 | 6 | 43517 | 127 | 50561474 |
| Gene mutation | 17.85 | 11.36 | 12 | 43511 | 1259 | 50560342 |
| Peripheral swelling | 17.81 | 11.36 | 104 | 43419 | 205832 | 50355769 |
| Tongue neoplasm malignant stage unspecified | 17.80 | 11.36 | 10 | 43513 | 761 | 50560840 |
| Peripheral sensory neuropathy | 17.77 | 11.36 | 25 | 43498 | 6566 | 50555035 |
| Gingival swelling | 17.74 | 11.36 | 19 | 43504 | 3776 | 50557825 |
| Osteitis | 17.59 | 11.36 | 17 | 43506 | 2993 | 50558608 |
| Bone marrow failure | 17.54 | 11.36 | 58 | 43465 | 27566 | 50534035 |
| Nasopharyngitis | 17.45 | 11.36 | 96 | 43427 | 192831 | 50368770 |
| Injection site bruising | 17.41 | 11.36 | 5 | 43518 | 36763 | 50524838 |
| Nail avulsion | 17.41 | 11.36 | 6 | 43517 | 138 | 50561463 |
| Vaginal discharge | 17.39 | 11.36 | 22 | 43501 | 5218 | 50556383 |
| Jaundice | 17.24 | 11.36 | 56 | 43467 | 26373 | 50535228 |
| Nail infection | 17.19 | 11.36 | 14 | 43509 | 1967 | 50559634 |
| Hair colour changes | 17.09 | 11.36 | 16 | 43507 | 2708 | 50558893 |
| Uterine leiomyoma | 17.08 | 11.36 | 27 | 43496 | 7864 | 50553737 |
| Paraesthesia | 16.98 | 11.36 | 168 | 43355 | 120075 | 50441526 |
| Endometrial hypertrophy | 16.88 | 11.36 | 7 | 43516 | 271 | 50561330 |
| Cardio-respiratory arrest | 16.84 | 11.36 | 13 | 43510 | 53879 | 50507722 |
| Multiple sclerosis relapse | 16.72 | 11.36 | 8 | 43515 | 42956 | 50518645 |
| Breast mass | 16.71 | 11.36 | 24 | 43499 | 6425 | 50555176 |
| Vitreous adhesions | 16.62 | 11.36 | 4 | 43519 | 23 | 50561578 |
| Hiccups | 16.61 | 11.36 | 13 | 43510 | 1726 | 50559875 |
| Hair texture abnormal | 16.55 | 11.36 | 18 | 43505 | 3638 | 50557963 |
| Acute promyelocytic leukaemia | 16.53 | 11.36 | 10 | 43513 | 874 | 50560727 |
| Urticaria | 16.25 | 11.36 | 57 | 43466 | 129504 | 50432097 |
| Invasive lobular breast carcinoma | 16.25 | 11.36 | 9 | 43514 | 666 | 50560935 |
| Pustule | 16.25 | 11.36 | 11 | 43512 | 1167 | 50560434 |
| HER2 positive breast cancer | 16.12 | 11.36 | 7 | 43516 | 304 | 50561297 |
| Neuroectodermal neoplasm | 16.10 | 11.36 | 3 | 43520 | 3 | 50561598 |
| Heart rate increased | 16.07 | 11.36 | 26 | 43497 | 77224 | 50484377 |
| Gamma-glutamyltransferase increased | 16.04 | 11.36 | 59 | 43464 | 29564 | 50532037 |
| Atrial enlargement | 16.01 | 11.36 | 7 | 43516 | 309 | 50561292 |
| Oroantral fistula | 15.81 | 11.36 | 6 | 43517 | 183 | 50561418 |
| Blister | 15.74 | 11.36 | 31 | 43492 | 85387 | 50476214 |
| Purulent discharge | 15.68 | 11.36 | 19 | 43504 | 4313 | 50557288 |
| Actinomycosis | 15.68 | 11.36 | 10 | 43513 | 959 | 50560642 |
| Meningioma | 15.65 | 11.36 | 17 | 43506 | 3432 | 50558169 |
| Asthenia | 15.41 | 11.36 | 371 | 43152 | 318671 | 50242930 |
| Oral surgery | 15.30 | 11.36 | 10 | 43513 | 1001 | 50560600 |
| Visual acuity reduced | 15.29 | 11.36 | 45 | 43478 | 20094 | 50541507 |
| Septic shock | 15.22 | 11.36 | 16 | 43507 | 57159 | 50504442 |
| Cardiotoxicity | 15.15 | 11.36 | 24 | 43499 | 7003 | 50554598 |
| Pyrexia | 15.13 | 11.36 | 233 | 43290 | 379970 | 50181631 |
| Paratracheal lymphadenopathy | 15.06 | 11.36 | 4 | 43519 | 36 | 50561565 |
| Radiation pneumonitis | 15.01 | 11.36 | 11 | 43512 | 1324 | 50560277 |
| Blood pressure fluctuation | 15 | 11.36 | 6 | 43517 | 35817 | 50525784 |
| Oestradiol abnormal | 14.96 | 11.36 | 4 | 43519 | 37 | 50561564 |
| Tremor | 14.79 | 11.36 | 50 | 43473 | 114853 | 50446748 |
| Mucosal inflammation | 14.73 | 11.36 | 71 | 43452 | 40071 | 50521530 |
| Psoriasis | 14.56 | 11.36 | 23 | 43500 | 68977 | 50492624 |
| Dysaesthesia | 14.54 | 11.36 | 17 | 43506 | 3718 | 50557883 |
| Hyperkalaemia | 14.52 | 11.36 | 12 | 43511 | 48077 | 50513524 |
| Acquired gene mutation | 14.51 | 11.36 | 9 | 43514 | 822 | 50560779 |
| Flushing | 14.46 | 11.36 | 22 | 43501 | 66993 | 50494608 |
| Disease recurrence | 14.43 | 11.36 | 44 | 43479 | 20037 | 50541564 |
| Hypoaesthesia teeth | 14.34 | 11.36 | 4 | 43519 | 44 | 50561557 |
| Benign lymph node neoplasm | 14.29 | 11.36 | 3 | 43520 | 8 | 50561593 |
| Wrong technique in product usage process | 14.26 | 11.36 | 16 | 43507 | 55494 | 50506107 |
| Postoperative wound complication | 14.15 | 11.36 | 9 | 43514 | 859 | 50560742 |
| Metastases to heart | 14.10 | 11.36 | 4 | 43519 | 47 | 50561554 |
| Toothache | 14.04 | 11.36 | 39 | 43484 | 16855 | 50544746 |
| Abdominal wall cyst | 14.03 | 11.36 | 3 | 43520 | 9 | 50561592 |
| Hypercholesterolaemia | 13.94 | 11.36 | 31 | 43492 | 11672 | 50549929 |
| Dental caries | 13.92 | 11.36 | 28 | 43495 | 9839 | 50551762 |
| Left ventricular dysfunction | 13.86 | 11.36 | 29 | 43494 | 10477 | 50551124 |
| Atypical femur fracture | 13.78 | 11.36 | 19 | 43504 | 4897 | 50556704 |
| Romberg test positive | 13.75 | 11.36 | 5 | 43518 | 135 | 50561466 |
| Erysipelas | 13.46 | 11.36 | 22 | 43501 | 6586 | 50555015 |
| Metastases to adrenals | 13.36 | 11.36 | 8 | 43515 | 686 | 50560915 |
| Bacteriuria | 13.29 | 11.36 | 8 | 43515 | 693 | 50560908 |
| Cardiac arrest | 13.24 | 11.36 | 33 | 43490 | 83618 | 50477983 |
| Chronic hepatic failure | 13.21 | 11.36 | 7 | 43516 | 474 | 50561127 |
| Hyperthyroidism | 13.12 | 11.36 | 31 | 43492 | 12144 | 50549457 |
| Tachycardia | 13.12 | 11.36 | 43 | 43480 | 99720 | 50461881 |
| Renal vein thrombosis | 13.08 | 11.36 | 6 | 43517 | 297 | 50561304 |
| Alopecia | 13.07 | 11.36 | 289 | 43234 | 244758 | 50316843 |
| Decreased appetite | 13.05 | 11.36 | 244 | 43279 | 200679 | 50360922 |
| Sedation | 13.03 | 11.36 | 5 | 43518 | 30605 | 50530996 |
| Varicophlebitis | 12.99 | 11.36 | 3 | 43520 | 14 | 50561587 |
| Breast haemorrhage | 12.87 | 11.36 | 5 | 43518 | 163 | 50561438 |
| Squamous cell breast carcinoma | 12.82 | 11.36 | 3 | 43520 | 15 | 50561586 |
| Nausea | 12.70 | 11.36 | 734 | 42789 | 704664 | 49856937 |
| Uveitis | 12.63 | 11.36 | 26 | 43497 | 9284 | 50552317 |
| Stomatitis | 12.60 | 11.36 | 138 | 43385 | 101206 | 50460395 |
| Red blood cell count decreased | 12.53 | 11.36 | 60 | 43463 | 33775 | 50527826 |
| Incorrect dose administered | 12.39 | 11.36 | 14 | 43509 | 48400 | 50513201 |
| Intraductal proliferative breast lesion | 12.33 | 11.36 | 13 | 43510 | 2537 | 50559064 |
| Metastases to ovary | 12.26 | 11.36 | 6 | 43517 | 344 | 50561257 |
| Dyshidrotic eczema | 12.23 | 11.36 | 7 | 43516 | 552 | 50561049 |
| Acquired porokeratosis | 12.22 | 11.36 | 3 | 43520 | 19 | 50561582 |
| Rash | 12.18 | 11.36 | 285 | 43238 | 437186 | 50124415 |
| Breast cancer in situ | 12.18 | 11.36 | 10 | 43513 | 1421 | 50560180 |
| Gingival ulceration | 12.12 | 11.36 | 8 | 43515 | 814 | 50560787 |
| Cardiac failure | 12.10 | 11.36 | 109 | 43414 | 75931 | 50485670 |
| Knee arthroplasty | 12.04 | 11.36 | 8 | 43515 | 35838 | 50525763 |
| Agitation | 12.03 | 11.36 | 17 | 43506 | 53367 | 50508234 |
| Oral pain | 12.02 | 11.36 | 48 | 43475 | 24985 | 50536616 |
| Anaemia | 12.00 | 11.36 | 293 | 43230 | 252163 | 50309438 |
| Periodontitis | 12 | 11.36 | 14 | 43509 | 3055 | 50558546 |
| Subacute cutaneous lupus erythematosus | 11.99 | 11.36 | 12 | 43511 | 2203 | 50559398 |
| Chronic hepatitis | 11.96 | 11.36 | 8 | 43515 | 832 | 50560769 |
| Diabetic hyperosmolar coma | 11.96 | 11.36 | 6 | 43517 | 363 | 50561238 |
| Lower limb fracture | 11.95 | 11.36 | 33 | 43490 | 14213 | 50547388 |
| Mastectomy | 11.95 | 11.36 | 10 | 43513 | 1459 | 50560142 |
| Pelvic mass | 11.94 | 11.36 | 9 | 43514 | 1130 | 50560471 |
| Blood oestrogen increased | 11.73 | 11.36 | 4 | 43519 | 89 | 50561512 |
| Therapeutic response decreased | 11.72 | 11.36 | 14 | 43509 | 47217 | 50514384 |
| Retinopathy | 11.67 | 11.36 | 13 | 43510 | 2699 | 50558902 |
| Bronchitis | 11.65 | 11.36 | 48 | 43475 | 104111 | 50457490 |
| Mood swings | 11.50 | 11.36 | 35 | 43488 | 15919 | 50545682 |
| Menopause | 11.50 | 11.36 | 12 | 43511 | 2315 | 50559286 |
| Influenza | 11.49 | 11.36 | 39 | 43484 | 89499 | 50472102 |
| Unresponsive to stimuli | 11.46 | 11.36 | 6 | 43517 | 30603 | 50530998 |
| Visual field defect | 11.45 | 11.36 | 19 | 43504 | 5760 | 50555841 |
| Glomerulonephritis | 11.44 | 11.36 | 10 | 43513 | 1549 | 50560052 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Growth retardation | 89.90 | 25.71 | 20 | 1481 | 1616 | 29571410 |
| Mesenteric vein thrombosis | 55.90 | 25.71 | 11 | 1490 | 487 | 29572539 |
| Secondary hypogonadism | 48.91 | 25.71 | 9 | 1492 | 277 | 29572749 |
| Metastases to bone | 43.46 | 25.71 | 17 | 1484 | 9881 | 29563145 |
| Haematocrit increased | 42.40 | 25.71 | 11 | 1490 | 1697 | 29571329 |
| Spondylolisthesis | 40.93 | 25.71 | 9 | 1492 | 687 | 29572339 |
| Off label use | 40.90 | 25.71 | 62 | 1439 | 300738 | 29272288 |
| Glucose tolerance decreased | 37.88 | 25.71 | 6 | 1495 | 73 | 29572953 |
| Blood testosterone increased | 37.79 | 25.71 | 9 | 1492 | 979 | 29572047 |
| Autoimmune thyroiditis | 37.36 | 25.71 | 9 | 1492 | 1027 | 29571999 |
| Breast cancer recurrent | 36.61 | 25.71 | 5 | 1496 | 19 | 29573007 |
| Product use issue | 34.26 | 25.71 | 25 | 1476 | 51419 | 29521607 |
| Oestradiol increased | 31.55 | 25.71 | 5 | 1496 | 61 | 29572965 |
| Performance enhancing product use | 31.12 | 25.71 | 5 | 1496 | 67 | 29572959 |
| Portal vein thrombosis | 31.07 | 25.71 | 10 | 1491 | 3299 | 29569727 |
| Osteonecrosis of jaw | 29.18 | 25.71 | 15 | 1486 | 16495 | 29556531 |
| Insulin-like growth factor increased | 26.82 | 25.71 | 7 | 1494 | 1104 | 29571922 |
| Androgenetic alopecia | 26.67 | 25.71 | 3 | 1498 | 0 | 29573026 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Metastases to bone | 661.91 | 11.82 | 288 | 34749 | 20147 | 64443548 |
| Metastases to liver | 341.06 | 11.82 | 193 | 34844 | 23748 | 64439947 |
| Malignant neoplasm progression | 332.74 | 11.82 | 356 | 34681 | 112515 | 64351180 |
| Metastases to lung | 322.21 | 11.82 | 160 | 34877 | 15104 | 64448591 |
| Hot flush | 274.42 | 11.82 | 216 | 34821 | 46019 | 64417676 |
| Breast cancer recurrent | 253.07 | 11.82 | 82 | 34955 | 2501 | 64461194 |
| Breast cancer metastatic | 228.59 | 11.82 | 100 | 34937 | 7069 | 64456626 |
| Breast cancer | 212.43 | 11.82 | 154 | 34883 | 28994 | 64434701 |
| Osteonecrosis | 209.96 | 11.82 | 151 | 34886 | 28078 | 64435617 |
| Bone pain | 199.46 | 11.82 | 182 | 34855 | 47390 | 64416305 |
| Arthralgia | 194.99 | 11.82 | 604 | 34433 | 441656 | 64022039 |
| Metastases to lymph nodes | 165.28 | 11.82 | 85 | 34952 | 8632 | 64455063 |
| Neoplasm progression | 139.94 | 11.82 | 140 | 34897 | 40824 | 64422871 |
| Pseudocirrhosis | 131.13 | 11.82 | 36 | 35001 | 609 | 64463086 |
| Osteonecrosis of jaw | 121.35 | 11.82 | 128 | 34909 | 39697 | 64423998 |
| Tumour marker increased | 119.40 | 11.82 | 51 | 34986 | 3399 | 64460296 |
| Disease progression | 114.90 | 11.82 | 244 | 34793 | 141436 | 64322259 |
| Drug ineffective | 108.19 | 11.82 | 182 | 34855 | 840065 | 63623630 |
| Tooth extraction | 106.78 | 11.82 | 66 | 34971 | 9535 | 64454160 |
| Carbohydrate antigen 15-3 increased | 103.51 | 11.82 | 33 | 35004 | 954 | 64462741 |
| Osteopenia | 101.73 | 11.82 | 77 | 34960 | 15463 | 64448232 |
| Ejection fraction decreased | 101.52 | 11.82 | 100 | 34937 | 28607 | 64435088 |
| Metastases to spine | 97.59 | 11.82 | 45 | 34992 | 3598 | 64460097 |
| Completed suicide | 87.08 | 11.82 | 10 | 35027 | 224404 | 64239291 |
| Fatigue | 86.38 | 11.82 | 697 | 34340 | 748033 | 63715662 |
| Vitreoretinal traction syndrome | 84.74 | 11.82 | 13 | 35024 | 0 | 64463695 |
| Bone lesion | 80.17 | 11.82 | 44 | 34993 | 5093 | 64458602 |
| Alopecia | 78.92 | 11.82 | 233 | 34804 | 165457 | 64298238 |
| Trigger finger | 77.27 | 11.82 | 38 | 34999 | 3507 | 64460188 |
| Tonsillar disorder | 75.10 | 11.82 | 26 | 35011 | 975 | 64462720 |
| Neutropenia | 68.07 | 11.82 | 284 | 34753 | 239340 | 64224355 |
| Toxicity to various agents | 66.27 | 11.82 | 60 | 34977 | 363453 | 64100242 |
| White blood cell count decreased | 65.89 | 11.82 | 212 | 34825 | 157625 | 64306070 |
| Retinal toxicity | 64.33 | 11.82 | 25 | 35012 | 1305 | 64462390 |
| Osteolysis | 60.96 | 11.82 | 30 | 35007 | 2773 | 64460922 |
| Cystoid macular oedema | 60.65 | 11.82 | 26 | 35011 | 1748 | 64461947 |
| Invasive ductal breast carcinoma | 54.39 | 11.82 | 34 | 35003 | 5008 | 64458687 |
| Nasal disorder | 54.31 | 11.82 | 28 | 35009 | 2856 | 64460839 |
| Malignant pleural effusion | 53.56 | 11.82 | 28 | 35009 | 2939 | 64460756 |
| Bone disorder | 53.06 | 11.82 | 55 | 34982 | 16704 | 64446991 |
| Lacrimation increased | 52.40 | 11.82 | 57 | 34980 | 18289 | 64445406 |
| Metastasis | 50.61 | 11.82 | 34 | 35003 | 5661 | 64458034 |
| Lymphoedema | 49.70 | 11.82 | 42 | 34995 | 9863 | 64453832 |
| Endometrial hyperplasia | 49.37 | 11.82 | 16 | 35021 | 488 | 64463207 |
| Neuropathy peripheral | 48.24 | 11.82 | 157 | 34880 | 117368 | 64346327 |
| Metastases to pleura | 48.13 | 11.82 | 20 | 35017 | 1244 | 64462451 |
| Hypotension | 47.43 | 11.82 | 84 | 34953 | 380890 | 64082805 |
| Peritoneal disorder | 45.40 | 11.82 | 16 | 35021 | 633 | 64463062 |
| Vulvovaginal dryness | 43.50 | 11.82 | 20 | 35017 | 1588 | 64462107 |
| Myalgia | 42.66 | 11.82 | 185 | 34852 | 158432 | 64305263 |
| Infusion related reaction | 42.58 | 11.82 | 18 | 35019 | 164449 | 64299246 |
| Pleural neoplasm | 42.45 | 11.82 | 12 | 35025 | 227 | 64463468 |
| Nail disorder | 42.11 | 11.82 | 36 | 35001 | 8588 | 64455107 |
| Pneumonia | 41.59 | 11.82 | 160 | 34877 | 559416 | 63904279 |
| Acute myeloid leukaemia | 41.27 | 11.82 | 62 | 34975 | 27401 | 64436294 |
| Pain in jaw | 41.16 | 11.82 | 77 | 34960 | 40678 | 64423017 |
| Metastases to central nervous system | 41.09 | 11.82 | 44 | 34993 | 13868 | 64449827 |
| Maternal exposure during pregnancy | 40.56 | 11.82 | 3 | 35034 | 95881 | 64367814 |
| Therapeutic product effect decreased | 40.36 | 11.82 | 7 | 35030 | 115344 | 64348351 |
| Oestrogen receptor assay positive | 40.32 | 11.82 | 12 | 35025 | 274 | 64463421 |
| Sialoadenitis | 40.11 | 11.82 | 19 | 35018 | 1614 | 64462081 |
| Carpal tunnel syndrome | 39.77 | 11.82 | 46 | 34991 | 15782 | 64447913 |
| Uterine polyp | 37.52 | 11.82 | 17 | 35020 | 1305 | 64462390 |
| Oestradiol increased | 37.23 | 11.82 | 9 | 35028 | 89 | 64463606 |
| Osteoporosis | 37.01 | 11.82 | 75 | 34962 | 42005 | 64421690 |
| Drug abuse | 36.72 | 11.82 | 13 | 35024 | 132361 | 64331334 |
| Joint stiffness | 36.56 | 11.82 | 62 | 34975 | 30342 | 64433353 |
| Hypertensive angiopathy | 36.44 | 11.82 | 9 | 35028 | 98 | 64463597 |
| Intentional overdose | 34.88 | 11.82 | 4 | 35033 | 89940 | 64373755 |
| Synovitis | 34.70 | 11.82 | 6 | 35031 | 99084 | 64364611 |
| Debridement | 34.16 | 11.82 | 17 | 35020 | 1609 | 64462086 |
| Vitreous detachment | 34.11 | 11.82 | 18 | 35019 | 1926 | 64461769 |
| Hair growth abnormal | 33.57 | 11.82 | 19 | 35018 | 2333 | 64461362 |
| Overdose | 33.22 | 11.82 | 23 | 35014 | 159543 | 64304152 |
| Metastases to pelvis | 32.88 | 11.82 | 12 | 35025 | 526 | 64463169 |
| Breast cancer female | 32.76 | 11.82 | 25 | 35012 | 5078 | 64458617 |
| Metastases to chest wall | 32.63 | 11.82 | 11 | 35026 | 380 | 64463315 |
| Acute phase reaction | 31.53 | 11.82 | 10 | 35027 | 284 | 64463411 |
| Treatment failure | 31.51 | 11.82 | 12 | 35025 | 116804 | 64346891 |
| Vaginal discharge | 31.12 | 11.82 | 22 | 35015 | 3975 | 64459720 |
| Nausea | 30.55 | 11.82 | 597 | 34440 | 785203 | 63678492 |
| Cardio-respiratory arrest | 30.28 | 11.82 | 8 | 35029 | 98385 | 64365310 |
| PIK3CA-activated mutation | 29.46 | 11.82 | 11 | 35026 | 514 | 64463181 |
| Tendonitis | 29.36 | 11.82 | 45 | 34992 | 20237 | 64443458 |
| Progesterone receptor assay positive | 29.35 | 11.82 | 9 | 35028 | 228 | 64463467 |
| Dental care | 29.14 | 11.82 | 12 | 35025 | 729 | 64462966 |
| Human epidermal growth factor receptor negative | 29.13 | 11.82 | 5 | 35032 | 5 | 64463690 |
| Metastatic neoplasm | 29.04 | 11.82 | 22 | 35015 | 4420 | 64459275 |
| Musculoskeletal chest pain | 28.79 | 11.82 | 46 | 34991 | 21433 | 64442262 |
| Sequestrectomy | 27.57 | 11.82 | 12 | 35025 | 837 | 64462858 |
| Metastases to skin | 27.06 | 11.82 | 14 | 35023 | 1438 | 64462257 |
| Bone sequestrum | 26.85 | 11.82 | 13 | 35024 | 1159 | 64462536 |
| Systemic lupus erythematosus | 26.52 | 11.82 | 5 | 35032 | 77607 | 64386088 |
| Second primary malignancy | 26.32 | 11.82 | 33 | 35004 | 12304 | 64451391 |
| Growth retardation | 26.11 | 11.82 | 14 | 35023 | 1547 | 64462148 |
| Sepsis | 25.82 | 11.82 | 54 | 34983 | 230287 | 64233408 |
| Secondary hypogonadism | 25.71 | 11.82 | 9 | 35028 | 349 | 64463346 |
| Breast pain | 25.71 | 11.82 | 25 | 35012 | 7036 | 64456659 |
| Metastases to the mediastinum | 25.69 | 11.82 | 10 | 35027 | 524 | 64463171 |
| Organising pneumonia | 25.62 | 11.82 | 28 | 35009 | 9027 | 64454668 |
| Fibrous histiocytoma | 25.60 | 11.82 | 10 | 35027 | 529 | 64463166 |
| Radiation skin injury | 25.30 | 11.82 | 13 | 35024 | 1317 | 64462378 |
| Acute kidney injury | 25.29 | 11.82 | 142 | 34895 | 449098 | 64014597 |
| Osteomyelitis | 25.25 | 11.82 | 50 | 34987 | 27537 | 64436158 |
| Periodontal disease | 25.06 | 11.82 | 14 | 35023 | 1677 | 64462018 |
| Metastases to soft tissue | 24.91 | 11.82 | 9 | 35028 | 383 | 64463312 |
| Tooth disorder | 24.74 | 11.82 | 44 | 34993 | 22358 | 64441337 |
| Pancreatic neoplasm | 24.71 | 11.82 | 13 | 35024 | 1382 | 64462313 |
| Hair texture abnormal | 24.48 | 11.82 | 17 | 35020 | 2987 | 64460708 |
| Stomatitis | 24.40 | 11.82 | 121 | 34916 | 109484 | 64354211 |
| Nail infection | 23.91 | 11.82 | 14 | 35023 | 1833 | 64461862 |
| Pyrexia | 23.75 | 11.82 | 192 | 34845 | 558452 | 63905243 |
| Cutaneous vasculitis | 23.72 | 11.82 | 23 | 35014 | 6450 | 64457245 |
| Glucose tolerance decreased | 23.46 | 11.82 | 6 | 35031 | 76 | 64463619 |
| Uterine leiomyoma | 23.38 | 11.82 | 21 | 35016 | 5348 | 64458347 |
| Papilloedema | 22.93 | 11.82 | 21 | 35016 | 5484 | 64458211 |
| Meningioma | 22.71 | 11.82 | 18 | 35019 | 3864 | 64459831 |
| Superinfection | 22.69 | 11.82 | 18 | 35019 | 3868 | 64459827 |
| Mesenteric vein thrombosis | 22.68 | 11.82 | 12 | 35025 | 1290 | 64462405 |
| Portal hypertension | 22.60 | 11.82 | 22 | 35015 | 6197 | 64457498 |
| Recall phenomenon | 22.57 | 11.82 | 11 | 35026 | 995 | 64462700 |
| Rheumatoid arthritis | 22.48 | 11.82 | 34 | 35003 | 164260 | 64299435 |
| Dry skin | 22.48 | 11.82 | 70 | 34967 | 51091 | 64412604 |
| Lower limb fracture | 22.41 | 11.82 | 32 | 35005 | 13513 | 64450182 |
| Pathological fracture | 22.33 | 11.82 | 26 | 35011 | 8979 | 64454716 |
| Mouth swelling | 22.29 | 11.82 | 20 | 35017 | 5087 | 64458608 |
| Nail avulsion | 21.94 | 11.82 | 6 | 35031 | 100 | 64463595 |
| Metastases to retroperitoneum | 21.61 | 11.82 | 8 | 35029 | 365 | 64463330 |
| Palmar-plantar erythrodysaesthesia syndrome | 21.45 | 11.82 | 48 | 34989 | 28771 | 64434924 |
| Haemorrhoids | 21.37 | 11.82 | 43 | 34994 | 23958 | 64439737 |
| Ascites | 21.21 | 11.82 | 78 | 34959 | 61923 | 64401772 |
| Carcinoembryonic antigen increased | 21.14 | 11.82 | 13 | 35024 | 1860 | 64461835 |
| Interstitial lung disease | 21.12 | 11.82 | 107 | 34930 | 97625 | 64366070 |
| Carbohydrate antigen 27.29 increased | 21.11 | 11.82 | 5 | 35032 | 45 | 64463650 |
| Product substitution issue | 20.91 | 11.82 | 36 | 35001 | 17825 | 64445870 |
| Tumour marker decreased | 20.91 | 11.82 | 5 | 35032 | 47 | 64463648 |
| Septic shock | 20.90 | 11.82 | 16 | 35021 | 105421 | 64358274 |
| Intentional product use issue | 20.85 | 11.82 | 13 | 35024 | 95351 | 64368344 |
| Borrelia infection | 20.29 | 11.82 | 6 | 35031 | 134 | 64463561 |
| Chronic inflammatory demyelinating polyradiculoneuropathy | 20.27 | 11.82 | 10 | 35027 | 929 | 64462766 |
| Bone debridement | 20.24 | 11.82 | 8 | 35029 | 437 | 64463258 |
| Hepatic lesion | 20.05 | 11.82 | 20 | 35017 | 5804 | 64457891 |
| Antisynthetase syndrome | 20.00 | 11.82 | 6 | 35031 | 141 | 64463554 |
| Metastases to peritoneum | 19.80 | 11.82 | 16 | 35021 | 3531 | 64460164 |
| Paraesthesia | 19.78 | 11.82 | 133 | 34904 | 134389 | 64329306 |
| Retinal detachment | 19.73 | 11.82 | 23 | 35014 | 7953 | 64455742 |
| Atypical femur fracture | 19.72 | 11.82 | 18 | 35019 | 4680 | 64459015 |
| Breast mass | 19.71 | 11.82 | 19 | 35018 | 5291 | 64458404 |
| Drug hypersensitivity | 19.60 | 11.82 | 65 | 34972 | 237750 | 64225945 |
| Pustule | 19.41 | 11.82 | 11 | 35026 | 1354 | 64462341 |
| Vertebral column mass | 19.21 | 11.82 | 6 | 35031 | 162 | 64463533 |
| Jaw operation | 19.16 | 11.82 | 9 | 35028 | 750 | 64462945 |
| Cardiac arrest | 19.10 | 11.82 | 34 | 35003 | 154030 | 64309665 |
| Asthenia | 18.91 | 11.82 | 332 | 34705 | 427712 | 64035983 |
| Invasive lobular breast carcinoma | 18.67 | 11.82 | 8 | 35029 | 537 | 64463158 |
| Spondylolisthesis | 18.63 | 11.82 | 14 | 35023 | 2780 | 64460915 |
| Blood oestrogen increased | 18.41 | 11.82 | 5 | 35032 | 81 | 64463614 |
| Recurrent cancer | 18.33 | 11.82 | 13 | 35024 | 2360 | 64461335 |
| Performance enhancing product use | 18.24 | 11.82 | 5 | 35032 | 84 | 64463611 |
| Autoimmune pancreatitis | 18.01 | 11.82 | 8 | 35029 | 586 | 64463109 |
| Osteosclerosis | 17.94 | 11.82 | 15 | 35022 | 3471 | 64460224 |
| Transient acantholytic dermatosis | 17.92 | 11.82 | 5 | 35032 | 90 | 64463605 |
| Respiratory failure | 17.87 | 11.82 | 38 | 34999 | 161145 | 64302550 |
| Oroantral fistula | 17.68 | 11.82 | 7 | 35030 | 384 | 64463311 |
| Dysgeusia | 17.64 | 11.82 | 61 | 34976 | 46986 | 64416709 |
| Mood swings | 17.63 | 11.82 | 33 | 35004 | 17435 | 64446260 |
| Pericarditis | 17.57 | 11.82 | 6 | 35031 | 62510 | 64401185 |
| Excessive eye blinking | 17.50 | 11.82 | 10 | 35027 | 1250 | 64462445 |
| Neuroectodermal neoplasm | 17.48 | 11.82 | 3 | 35034 | 3 | 64463692 |
| General physical health deterioration | 17.45 | 11.82 | 55 | 34982 | 204370 | 64259325 |
| Actinomycosis | 17.32 | 11.82 | 9 | 35028 | 933 | 64462762 |
| Intraductal proliferative breast lesion | 17.12 | 11.82 | 12 | 35025 | 2139 | 64461556 |
| Neoplasm recurrence | 17.03 | 11.82 | 15 | 35022 | 3724 | 64459971 |
| Benign lymph node neoplasm | 17.02 | 11.82 | 3 | 35034 | 4 | 64463691 |
| Oestradiol decreased | 17.02 | 11.82 | 3 | 35034 | 4 | 64463691 |
| Hyperkalaemia | 16.87 | 11.82 | 18 | 35019 | 101111 | 64362584 |
| Henoch-Schonlein purpura | 16.85 | 11.82 | 12 | 35025 | 2194 | 64461501 |
| Rhabdomyolysis | 16.84 | 11.82 | 15 | 35022 | 91711 | 64371984 |
| Mastectomy | 16.66 | 11.82 | 9 | 35028 | 1009 | 64462686 |
| Breast swelling | 16.42 | 11.82 | 9 | 35028 | 1039 | 64462656 |
| Hypoaesthesia teeth | 16.42 | 11.82 | 4 | 35033 | 41 | 64463654 |
| Blood pressure fluctuation | 16.38 | 11.82 | 4 | 35033 | 51867 | 64411828 |
| Febrile neutropenia | 16.36 | 11.82 | 50 | 34987 | 187607 | 64276088 |
| Retinopathy | 16.33 | 11.82 | 14 | 35023 | 3351 | 64460344 |
| Pain in extremity | 16.33 | 11.82 | 243 | 34794 | 302842 | 64160853 |
| Madarosis | 16.26 | 11.82 | 12 | 35025 | 2318 | 64461377 |
| Pneumonia aspiration | 16.13 | 11.82 | 6 | 35031 | 59265 | 64404430 |
| Breast haemorrhage | 16.11 | 11.82 | 5 | 35032 | 132 | 64463563 |
| Vitreous adhesions | 16.08 | 11.82 | 4 | 35033 | 45 | 64463650 |
| Ischaemic stroke | 15.91 | 11.82 | 43 | 34994 | 28992 | 64434703 |
| Exposed bone in jaw | 15.90 | 11.82 | 14 | 35023 | 3473 | 64460222 |
| Blood testosterone increased | 15.87 | 11.82 | 8 | 35029 | 778 | 64462917 |
| Unresponsive to stimuli | 15.69 | 11.82 | 4 | 35033 | 50389 | 64413306 |
| Gastrointestinal haemorrhage | 15.69 | 11.82 | 30 | 35007 | 132282 | 64331413 |
| Varicophlebitis | 15.66 | 11.82 | 3 | 35034 | 8 | 64463687 |
| Rhabdomyosarcoma | 15.63 | 11.82 | 5 | 35032 | 146 | 64463549 |
| Autoimmune hepatitis | 15.48 | 11.82 | 23 | 35014 | 10061 | 64453634 |
| Uveitis | 15.39 | 11.82 | 26 | 35011 | 12682 | 64451013 |
| Hypersensitivity | 15.30 | 11.82 | 55 | 34982 | 196397 | 64267298 |
| Vascular purpura | 15.27 | 11.82 | 12 | 35025 | 2544 | 64461151 |
| Abdominal wall cyst | 15.16 | 11.82 | 3 | 35034 | 10 | 64463685 |
| Portal vein thrombosis | 15.12 | 11.82 | 16 | 35021 | 4975 | 64458720 |
| Hair colour changes | 15.10 | 11.82 | 14 | 35023 | 3713 | 64459982 |
| Breast cancer in situ | 15.09 | 11.82 | 8 | 35029 | 864 | 64462831 |
| Pleural effusion | 15.08 | 11.82 | 119 | 34918 | 126440 | 64337255 |
| Metabolic acidosis | 15.07 | 11.82 | 10 | 35027 | 70948 | 64392747 |
| Joint swelling | 15.04 | 11.82 | 63 | 34974 | 215319 | 64248376 |
| Cholestasis | 14.97 | 11.82 | 56 | 34981 | 44816 | 64418879 |
| Lichen sclerosus | 14.88 | 11.82 | 8 | 35029 | 889 | 64462806 |
| Intermenstrual bleeding | 14.77 | 11.82 | 16 | 35021 | 5109 | 64458586 |
| Bacteriuria | 14.51 | 11.82 | 8 | 35029 | 934 | 64462761 |
| Agitation | 14.44 | 11.82 | 16 | 35021 | 88351 | 64375344 |
| Oral pain | 14.35 | 11.82 | 40 | 34997 | 27453 | 64436242 |
| Dental caries | 14.29 | 11.82 | 23 | 35014 | 10777 | 64452918 |
| BRCA2 gene mutation | 14.28 | 11.82 | 4 | 35033 | 73 | 64463622 |
| Full blood count abnormal | 14.28 | 11.82 | 42 | 34995 | 29715 | 64433980 |
| Hypercholesterolaemia | 14.23 | 11.82 | 28 | 35009 | 15345 | 64448350 |
| Squamous cell breast carcinoma | 14.19 | 11.82 | 3 | 35034 | 15 | 64463680 |
| Atrial enlargement | 14.16 | 11.82 | 7 | 35030 | 653 | 64463042 |
| Back pain | 14.03 | 11.82 | 202 | 34835 | 249969 | 64213726 |
| Uterine cancer | 13.95 | 11.82 | 12 | 35025 | 2886 | 64460809 |
| Postoperative wound complication | 13.90 | 11.82 | 9 | 35028 | 1409 | 64462286 |
| Confusional state | 13.89 | 11.82 | 84 | 34953 | 261060 | 64202635 |
| Tooth loss | 13.79 | 11.82 | 17 | 35020 | 6230 | 64457465 |
| Injection site erythema | 13.70 | 11.82 | 11 | 35026 | 70789 | 64392906 |
| Visual acuity reduced | 13.69 | 11.82 | 39 | 34998 | 27102 | 64436593 |
| Sjogren's syndrome | 13.65 | 11.82 | 7 | 35030 | 706 | 64462989 |
| Subacute cutaneous lupus erythematosus | 13.50 | 11.82 | 12 | 35025 | 3013 | 64460682 |
| Peripheral sensory neuropathy | 13.41 | 11.82 | 23 | 35014 | 11355 | 64452340 |
| Dysaesthesia | 13.36 | 11.82 | 15 | 35022 | 4980 | 64458715 |
| Renal vein thrombosis | 13.36 | 11.82 | 6 | 35031 | 451 | 64463244 |
| Pelvic mass | 13.35 | 11.82 | 8 | 35029 | 1092 | 64462603 |
| Alopecia areata | 13.28 | 11.82 | 9 | 35028 | 1519 | 64462176 |
| Tremor | 13.27 | 11.82 | 39 | 34998 | 148191 | 64315504 |
| Visual field defect | 13.11 | 11.82 | 19 | 35018 | 8127 | 64455568 |
| Blood copper increased | 13.09 | 11.82 | 3 | 35034 | 23 | 64463672 |
| Off label use | 13.01 | 11.82 | 254 | 34783 | 632552 | 63831143 |
| Metastases to ovary | 12.94 | 11.82 | 5 | 35032 | 257 | 64463438 |
| Tachycardia | 12.93 | 11.82 | 40 | 34997 | 149539 | 64314156 |
| Toothache | 12.90 | 11.82 | 29 | 35008 | 17430 | 64446265 |
| Gingivitis | 12.53 | 11.82 | 18 | 35019 | 7641 | 64456054 |
| Chronic hepatic failure | 12.42 | 11.82 | 7 | 35030 | 852 | 64462843 |
| Inner ear disorder | 12.41 | 11.82 | 6 | 35031 | 533 | 64463162 |
| Menopause | 12.38 | 11.82 | 9 | 35028 | 1699 | 64461996 |
| Metastases to abdominal wall | 12.31 | 11.82 | 4 | 35033 | 123 | 64463572 |
| Chronic hepatitis | 12.31 | 11.82 | 8 | 35029 | 1260 | 64462435 |
| Mucosal ulceration | 12.29 | 11.82 | 9 | 35028 | 1718 | 64461977 |
| Breast cancer stage IV | 12.25 | 11.82 | 6 | 35031 | 549 | 64463146 |
| Dyshidrotic eczema | 12.18 | 11.82 | 6 | 35031 | 556 | 64463139 |
| Cervical polyp | 12.16 | 11.82 | 4 | 35033 | 128 | 64463567 |
| Multiple organ dysfunction syndrome | 12.02 | 11.82 | 23 | 35014 | 101390 | 64362305 |
| Hormone receptor positive breast cancer | 12 | 11.82 | 5 | 35032 | 313 | 64463382 |
| Neoplasm malignant | 11.99 | 11.82 | 35 | 35002 | 24653 | 64439042 |
| Eosinophilia | 11.90 | 11.82 | 3 | 35034 | 38073 | 64425622 |
| Respiratory arrest | 11.89 | 11.82 | 7 | 35030 | 52978 | 64410717 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | L02BG03 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ENDOCRINE THERAPY HORMONE ANTAGONISTS AND RELATED AGENTS Aromatase inhibitors |
| FDA MoA | N0000175080 | Aromatase Inhibitors |
| FDA EPC | N0000175563 | Aromatase Inhibitor |
| CHEBI has role | CHEBI:35610 | antineoplastic agents |
| CHEBI has role | CHEBI:50790 | aromatase inhibitors |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D018931 | Antineoplastic Agents, Hormonal |
| MeSH PA | D047072 | Aromatase Inhibitors |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D004965 | Estrogen Antagonists |
| MeSH PA | D006727 | Hormone Antagonists |
| MeSH PA | D065088 | Steroid Synthesis Inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hormone receptor positive malignant neoplasm of breast | indication | 417181009 | |
| Malignant tumor of ovary | off-label use | 363443007 | DOID:2394 |
| Hypercholesterolemia | contraindication | 13644009 | |
| Pregnancy, function | contraindication | 289908002 | |
| Osteopenia | contraindication | 312894000 | |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.56 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Aromatase | Enzyme | INHIBITOR | IC50 | 6.22 | WOMBAT-PK | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4020948 | VUID |
| N0000148427 | NUI |
| D00960 | KEGG_DRUG |
| 262485 | RXNORM |
| C0290883 | UMLSCUI |
| CHEBI:2704 | CHEBI |
| CHEMBL1399 | ChEMBL_ID |
| DB01217 | DRUGBANK_ID |
| D000077384 | MESH_DESCRIPTOR_UI |
| 2187 | PUBCHEM_CID |
| 5137 | IUPHAR_LIGAND_ID |
| 7274 | INN_ID |
| 2Z07MYW1AZ | UNII |
| 173198 | MMSL |
| 4200 | MMSL |
| 5599 | MMSL |
| d03873 | MMSL |
| 005094 | NDDF |
| 4020948 | VANDF |
| 108774000 | SNOMEDCT_US |
| 386910003 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Anastrozole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7536 | TABLET, FILM COATED | 1 mg | ORAL | ANDA | 28 sections |
| ARIMIDEX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-0201 | TABLET | 1 mg | ORAL | NDA | 28 sections |
| Anastrozole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5356 | TABLET, FILM COATED | 1 mg | ORAL | ANDA | 29 sections |
| Anastrozole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6195 | TABLET | 1 mg | ORAL | ANDA | 26 sections |
| Anastrozole | Human Prescription Drug Label | 1 | 16571-421 | TABLET | 1 mg | ORAL | ANDA | 29 sections |
| Anastrozole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-035 | TABLET | 1 mg | ORAL | ANDA | 26 sections |
| Anastrozole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-990 | TABLET | 1 mg | ORAL | ANDA | 27 sections |
| Anastrozole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-161 | TABLET | 1 mg | ORAL | ANDA | 28 sections |
| Anastrozole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42291-085 | TABLET, FILM COATED | 1 mg | ORAL | ANDA | 28 sections |
| ANASTROZOLE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-383 | TABLET | 1 mg | ORAL | ANDA | 31 sections |
| Anastrozole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45865-909 | TABLET | 1 mg | ORAL | ANDA | 27 sections |
| Anastrozole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-2453 | TABLET | 1 mg | ORAL | ANDA | 28 sections |
| Anastrozole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-2453 | TABLET | 1 mg | ORAL | ANDA | 28 sections |
| ANASTROZOLE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-5002 | TABLET | 1 mg | ORAL | ANDA | 30 sections |
| Anastrozole | Human Prescription Drug Label | 1 | 50090-5812 | TABLET, FILM COATED | 1 mg | ORAL | ANDA | 28 sections |
| ANASTROZOLE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50268-075 | TABLET | 1 mg | ORAL | ANDA | 31 sections |
| Anastrozole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51655-638 | TABLET | 1 mg | ORAL | ANDA | 15 sections |
| ANASTROZOLE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51991-620 | TABLET | 1 mg | ORAL | ANDA | 31 sections |
| ARIMIDEX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-5000 | TABLET | 1 mg | ORAL | NDA | 28 sections |
| Anastrozole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-6130 | TABLET | 1 mg | ORAL | ANDA | 27 sections |
| Testozole | HUMAN PRESCRIPTION DRUG LABEL | 2 | 57377-060 | PELLET, IMPLANTABLE | 4 mg | SUBCUTANEOUS | unapproved drug other | 8 sections |
| Testozole | HUMAN PRESCRIPTION DRUG LABEL | 2 | 57377-060 | PELLET, IMPLANTABLE | 4 mg | SUBCUTANEOUS | unapproved drug other | 8 sections |
| Anastrozole | Human Prescription Drug Label | 1 | 59651-236 | TABLET, FILM COATED | 1 mg | ORAL | ANDA | 28 sections |
| Anastrozole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60429-286 | TABLET, FILM COATED | 1 mg | ORAL | ANDA | 27 sections |
| Anastrozole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60687-112 | TABLET, COATED | 1 mg | ORAL | ANDA | 28 sections |
| Anastrozole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60763-376 | TABLET | 1 mg | ORAL | ANDA | 27 sections |
| Anastrozole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60763-388 | TABLET | 1 mg | ORAL | Export only | 27 sections |
| Anastrozole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62033-0376 | TABLET, COATED | 1 mg | ORAL | Export only | 17 sections |
| Anastrozole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62135-490 | TABLET | 1 mg | ORAL | ANDA | 30 sections |
| Anastrozole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62175-710 | TABLET, FILM COATED | 1 mg | ORAL | ANDA | 28 sections |