vincamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| vinca alkaloids | 3643 | 1617-90-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A major alkaloid of Vinca minor L., Apocynaceae. It has been used therapeutically as a vasodilator and antihypertensive agent, particularly in cerebrovascular disorders.
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 20 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C04AX07 | CARDIOVASCULAR SYSTEM PERIPHERAL VASODILATORS PERIPHERAL VASODILATORS Other peripheral vasodilators |
| CHEBI has role | CHEBI:25212 | metabolites |
| CHEBI has role | CHEBI:35620 | vasodilator agents |
| CHEBI has role | CHEBI:35674 | antihypertensive drugs |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D014665 | Vasodilator Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Intracranial hemorrhage | contraindication | 1386000 | |
| Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
| Qualitative platelet disorder | contraindication | 267532001 | |
| Cerebral hemorrhage | contraindication | 274100004 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.67 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M1 | GPCR | ALLOSTERIC MODULATOR | Kd | 4.80 | IUPHAR | ||||
| Muscarinic acetylcholine receptor M2 | GPCR | ALLOSTERIC MODULATOR | Kd | 5.10 | IUPHAR | ||||
| Muscarinic acetylcholine receptor M3 | GPCR | ALLOSTERIC MODULATOR | Kd | 5.70 | IUPHAR | ||||
| Muscarinic acetylcholine receptor M4 | GPCR | ALLOSTERIC MODULATOR | Kd | 4.20 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| N0000166956 | NUI |
| D08677 | KEGG_DRUG |
| C0042674 | UMLSCUI |
| CHEBI:9985 | CHEBI |
| CHEMBL1165342 | ChEMBL_ID |
| DB13374 | DRUGBANK_ID |
| D014749 | MESH_DESCRIPTOR_UI |
| 15376 | PUBCHEM_CID |
| 349 | IUPHAR_LIGAND_ID |
| 2714 | INN_ID |
| 996XVD0JHT | UNII |
| 11201 | RXNORM |
| 005682 | NDDF |
| 698876002 | SNOMEDCT_US |
Pharmaceutical products:
None