uridine triphosphate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3639 63-39-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • uridine triphosphate
  • UTP
  • uteplex
Uridine 5'-(tetrahydrogen triphosphate). A uracil nucleotide containing three phosphate groups esterified to the sugar moiety.
  • Molecular weight: 484.14
  • Formula: C9H15N2O15P3
  • CLOGP: -4.61
  • LIPINSKI: 2
  • HAC: 17
  • HDO: 7
  • TPSA: 258.92
  • ALOGS: -1.76
  • ROTB: 8

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pancoast's syndrome 40.51 40.25 3 5 1 2358076

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

None

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.0 acidic
pKa2 3.35 acidic
pKa3 6.05 acidic
pKa4 9.23 acidic
pKa5 11.76 acidic
pKa6 13.81 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
P2Y purinoceptor 2 GPCR AGONIST EC50 8.10 IUPHAR
P2Y purinoceptor 4 GPCR AGONIST EC50 6.30 IUPHAR
P2Y purinoceptor 6 GPCR AGONIST EC50 5.20 IUPHAR
P2Y purinoceptor 11 GPCR AGONIST EC50 5.20 IUPHAR
P2X purinoceptor 3 Ion channel Ki 5.58 PDSP
P2Y purinoceptor 4 Unclassified AGONIST EC50 5.60 IUPHAR

External reference:

IDSource
CHEMBL336296 ChEMBL_ID
DB04005 DRUGBANK_ID
CHEBI:46398 CHEBI
D014544 MESH_DESCRIPTOR_UI
6133 PUBCHEM_CID
1734 IUPHAR_LIGAND_ID

Pharmaceutical products:

None