triclosan Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3631 3380-34-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • triclosan
A diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action.
  • Molecular weight: 289.54
  • Formula: C12H7Cl3O2
  • CLOGP: 5.53
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 1
  • TPSA: 29.46
  • ALOGS: -4.68
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
July 11, 1997 FDA COLGATE PALMOLIVE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC D08AE04 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Phenol and derivatives
ATC D09AA06 DERMATOLOGICALS
MEDICATED DRESSINGS
MEDICATED DRESSINGS
Medicated dressings with antiinfectives
CHEBI has role CHEBI:24127 fungicide
CHEBI has role CHEBI:38068 antimalarial
CHEBI has role CHEBI:88188 drug allergen
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D000963 Antimetabolites
MeSH PA D054872 Fatty Acid Synthesis Inhibitors
MeSH PA D000960 Hypolipidemic Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Conduction disorder of the heart contraindication 44808001
Decreased respiratory function contraindication 80954004
Open wound contraindication 125643001
Seizure disorder contraindication 128613002
Denuded skin contraindication 418242004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.67 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Carbonyl reductase [NADPH] 1 Enzyme Ki 7.22 CHEMBL
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Enzyme INHIBITOR IC50 6.37 CHEMBL CHEMBL
Enoyl-[acyl-carrier-protein] reductase [NADPH] Enzyme IC50 7.23 CHEMBL
Enoyl-[acyl-carrier-protein] reductase [NADH] Enzyme Ki 6.70 CHEMBL
Enoyl-ACP reductase Unclassified IC50 6.70 CHEMBL
Enoyl-[acyl-carrier-protein] reductase [NADH] Enzyme IC50 5.89 CHEMBL
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI Enzyme IC50 7.15 CHEMBL
Enoyl-acyl-carrier protein reductase Enzyme Ki 10.28 CHEMBL
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Enzyme IC50 6.30 CHEMBL
Enoyl-acyl carrier reductase; Enoyl-acyl carrier reductase ENR Enzyme IC50 7.82 CHEMBL

External reference:

IDSource
4020553 VUID
N0000148259 NUI
C0040958 UMLSCUI
D06226 KEGG_DRUG
4NM5039Y5X UNII
2988 INN_ID
125577003 SNOMEDCT_US
4020553 VANDF
10795 RXNORM
387054001 SNOMEDCT_US
5622 MMSL
003179 NDDF
CHEBI:164200 CHEBI
CHEMBL849 ChEMBL_ID
TCL PDB_CHEM_ID
DB08604 DRUGBANK_ID
5564 PUBCHEM_CID
D014260 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Antibacterial Hand HUMAN OTC DRUG LABEL 1 0363-0243 LIQUID 0.15 kg TOPICAL OTC monograph final 8 sections
STUDIO 35 HUMAN OTC DRUG LABEL 1 0363-3701 LIQUID 1.50 mg TOPICAL OTC monograph not final 7 sections
Medicated Soft N Sure HUMAN OTC DRUG LABEL 1 0519-1229 LIQUID 0.50 g TOPICAL OTC MONOGRAPH NOT FINAL 9 sections
Kindest Kare Antimicrobial Foaming Handwash HUMAN OTC DRUG LABEL 1 0519-1452 LIQUID 0.75 g TOPICAL OTC MONOGRAPH NOT FINAL 9 sections
CV Medicated HUMAN OTC DRUG LABEL 1 0519-6262 SOAP 0.50 g TOPICAL OTC monograph not final 9 sections
Moist SURE HUMAN OTC DRUG LABEL 1 0699-5720 LIQUID 7.50 mg TOPICAL OTC MONOGRAPH FINAL 9 sections
Moist SURE HUMAN OTC DRUG LABEL 1 0699-5725 LIQUID 5 mg TOPICAL OTC MONOGRAPH FINAL 9 sections
Moist SURE HUMAN OTC DRUG LABEL 1 0699-5726 LIQUID 5 mg TOPICAL OTC MONOGRAPH FINAL 9 sections
Moist SURE HUMAN OTC DRUG LABEL 1 0699-5727 LIQUID 5 mg TOPICAL OTC MONOGRAPH FINAL 9 sections
Clearskin HUMAN OTC DRUG LABEL 1 10096-0199 GEL 0.50 mL TOPICAL OTC monograph not final 6 sections
Naturals Cucumber and Melon HUMAN OTC DRUG LABEL 1 10096-0208 LIQUID 2 mg TOPICAL OTC monograph not final 6 sections
Naturals Pomegranate and Mango HUMAN OTC DRUG LABEL 1 10096-0209 LIQUID 2 mg TOPICAL OTC monograph not final 6 sections
Naturals HUMAN OTC DRUG LABEL 1 10096-0212 LIQUID 0.50 mL TOPICAL OTC monograph not final 6 sections
AntiBAC FH FOAM Cucumber Aloe with Microhydration HUMAN OTC DRUG LABEL 1 11084-004 SOLUTION 0.70 g TOPICAL OTC monograph not final 8 sections
Astound Antibacterial HUMAN OTC DRUG LABEL 1 11084-020 LIQUID 0.30 mL TOPICAL OTC monograph not final 7 sections
AntiBac Foam Wash HUMAN OTC DRUG LABEL 1 11084-053 LIQUID 0.30 mL TOPICAL OTC monograph not final 7 sections
DebMed Antimicrobial Body Wash and Shampoo HUMAN OTC DRUG LABEL 1 11084-061 LIQUID 0.70 mL TOPICAL OTC monograph not final 7 sections
SBS UltraGreen HUMAN OTC DRUG LABEL 1 11084-075 GEL 0.15 mL TOPICAL OTC monograph not final 7 sections
Deb Gold HUMAN OTC DRUG LABEL 1 11084-076 LIQUID 0.15 mL TOPICAL OTC monograph not final 7 sections
SBS UltraPink HUMAN OTC DRUG LABEL 1 11084-077 GEL 0.15 mL TOPICAL OTC monograph not final 7 sections
Refresh AntiBac Foam HUMAN OTC DRUG LABEL 1 11084-100 LIQUID 3 g TOPICAL OTC monograph not final 7 sections
ICI Pleasantly Perfumed Antibacterial Foam Handwash HUMAN OTC DRUG LABEL 1 11084-103 SOAP 0.00 g TOPICAL OTC monograph not final 7 sections
Appeal Antibacterial Hand Wash HUMAN OTC DRUG LABEL 1 11084-105 LIQUID 0.30 mL TOPICAL OTC monograph not final 7 sections
Panache HUMAN OTC DRUG LABEL 1 11084-115 LIQUID 0.55 mL TOPICAL OTC monograph not final 6 sections
Deb Med Antibacterial Foam Hand Wash HUMAN OTC DRUG LABEL 1 11084-116 LIQUID 0.30 mL TOPICAL OTC monograph not final 7 sections
Action Chemical Antibac Clear HUMAN OTC DRUG LABEL 1 11084-147 LIQUID 0.30 mg TOPICAL OTC monograph not final 7 sections
Deb Antimicrobial Fragrance and Dye Free HUMAN OTC DRUG LABEL 1 11084-148 LIQUID 0.30 mg TOPICAL OTC monograph not final 7 sections
SBS UltraGreen HUMAN OTC DRUG LABEL 1 11084-175 LIQUID 1.50 mg TOPICAL OTC monograph not final 7 sections
Panache HUMAN OTC DRUG LABEL 1 11084-215 LIQUID 0.50 mg TOPICAL OTC monograph not final 7 sections
AntiBac Foam Wash/Aerogreen HUMAN OTC DRUG LABEL 1 11084-253 LIQUID 0.30 mg TOPICAL OTC monograph not final 7 sections