triclosan 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3631 3380-34-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • triclosan
A diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action.
  • Molecular weight: 289.54
  • Formula: C12H7Cl3O2
  • CLOGP: 5.23
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 1
  • TPSA: 29.46
  • ALOGS: -4.68
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
July 11, 1997 FDA COLGATE PALMOLIVE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxic epidermal necrolysis 169.05 99.41 32 82 18121 29556292

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxic epidermal necrolysis 159.15 81.75 32 126 37134 64461440

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D08AE04 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Phenol and derivatives
ATC D09AA06 DERMATOLOGICALS
MEDICATED DRESSINGS
MEDICATED DRESSINGS
Medicated dressings with antiinfectives
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D000963 Antimetabolites
MeSH PA D054872 Fatty Acid Synthesis Inhibitors
MeSH PA D000960 Hypolipidemic Agents
CHEBI has role CHEBI:24127 fungicides
CHEBI has role CHEBI:33282 bactericides
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:38068 antimalarials
CHEBI has role CHEBI:50683 dihydrofolic acid reductase inhibitors
CHEBI has role CHEBI:77853 persistent organic pollutants
CHEBI has role CHEBI:88188 allergenic drug
CHEBI has role CHEBI:139512 NADH-specific enoyl-ACP reductase inhibitor

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Conduction disorder of the heart contraindication 44808001
Decreased respiratory function contraindication 80954004
Open wound contraindication 125643001
Seizure disorder contraindication 128613002
Denuded skin contraindication 418242004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.67 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Carbonyl reductase [NADPH] 1 Enzyme Ki 7.22 CHEMBL
78 kDa glucose-regulated protein Unclassified IC50 4 CHEMBL
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Enzyme INHIBITOR IC50 6.37 CHEMBL CHEMBL
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI Enzyme IC50 7.15 CHEMBL
Enoyl-acyl-carrier protein reductase Enzyme Ki 10.28 CHEMBL
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Enzyme IC50 6.30 CHEMBL
Enoyl-acyl carrier reductase; Enoyl-acyl carrier reductase ENR Enzyme IC50 7.82 CHEMBL
Enoyl-ACP reductase Enzyme IC50 6.70 CHEMBL
Enoyl-[acyl-carrier-protein] reductase [NADPH] Enzyme IC50 7.23 CHEMBL
Enoyl-[acyl-carrier-protein] reductase [NADH] Enzyme IC50 5.89 CHEMBL
Enoyl-[acyl-carrier-protein] reductase [NADH] Enzyme Ki 6.70 CHEMBL
Enoyl-[acyl-carrier-protein] reductase [NADH] Enzyme Ki 6.70 CHEMBL

External reference:

IDSource
4020553 VUID
N0000148259 NUI
D06226 KEGG_DRUG
4020553 VANDF
C0040958 UMLSCUI
CHEBI:164200 CHEBI
TCL PDB_CHEM_ID
CHEMBL849 ChEMBL_ID
DB08604 DRUGBANK_ID
D014260 MESH_DESCRIPTOR_UI
5564 PUBCHEM_CID
2988 INN_ID
4NM5039Y5X UNII
10795 RXNORM
5622 MMSL
003179 NDDF
125577003 SNOMEDCT_US
387054001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Antibacterial Hand HUMAN OTC DRUG LABEL 1 0363-0243 LIQUID 0.15 kg TOPICAL OTC monograph final 12 sections
STUDIO 35SPRING MORNING HUMAN OTC DRUG LABEL 1 0363-3701 LIQUID 1.50 mg TOPICAL OTC monograph not final 11 sections
Medicated Soft N Sure Healthcare Personnel Handwash HUMAN OTC DRUG LABEL 1 0519-1229 LIQUID 0.50 g TOPICAL OTC MONOGRAPH NOT FINAL 12 sections
Kindest Kare Antimicrobial Foaming Handwash Healthcare Personnel Handwash HUMAN OTC DRUG LABEL 1 0519-1452 LIQUID 0.75 g TOPICAL OTC MONOGRAPH NOT FINAL 12 sections
CV Medicated HUMAN OTC DRUG LABEL 1 0519-6262 SOAP 0.50 g TOPICAL OTC monograph not final 12 sections
Moist SURE HUMAN OTC DRUG LABEL 1 0699-5720 LIQUID 7.50 mg TOPICAL OTC MONOGRAPH FINAL 10 sections
Moist SURE HUMAN OTC DRUG LABEL 1 0699-5725 LIQUID 5 mg TOPICAL OTC MONOGRAPH FINAL 10 sections
Moist SURE HUMAN OTC DRUG LABEL 1 0699-5726 LIQUID 5 mg TOPICAL OTC MONOGRAPH FINAL 10 sections
Moist SURE HUMAN OTC DRUG LABEL 1 0699-5727 LIQUID 5 mg TOPICAL OTC MONOGRAPH FINAL 10 sections
ClearskinPore Penetrating Cleanser HUMAN OTC DRUG LABEL 1 10096-0199 GEL 0.50 mL TOPICAL OTC monograph not final 9 sections
Naturals Cucumber and MelonAnti Bacterial Hand HUMAN OTC DRUG LABEL 1 10096-0208 LIQUID 2 mg TOPICAL OTC monograph not final 11 sections
Naturals Pomegranate and MangoAnti-Bacterial Hand HUMAN OTC DRUG LABEL 1 10096-0209 LIQUID 2 mg TOPICAL OTC monograph not final 11 sections
NaturalsAntibacterial Liquid Soap Vanilla HUMAN OTC DRUG LABEL 1 10096-0212 LIQUID 0.50 mL TOPICAL OTC monograph not final 10 sections
Astound Antibacterial HUMAN OTC DRUG LABEL 1 11084-020 LIQUID 0.30 mL TOPICAL OTC monograph not final 9 sections
AntiBac Foam Wash HUMAN OTC DRUG LABEL 1 11084-053 LIQUID 0.30 mL TOPICAL OTC monograph not final 9 sections
DebMed Antimicrobial Body Wash and Shampoo HUMAN OTC DRUG LABEL 1 11084-061 LIQUID 0.70 mL TOPICAL OTC monograph not final 8 sections
SBS UltraGreen HUMAN OTC DRUG LABEL 1 11084-075 GEL 0.15 mL TOPICAL OTC monograph not final 8 sections
Deb Gold HUMAN OTC DRUG LABEL 1 11084-076 LIQUID 0.15 mL TOPICAL OTC monograph not final 8 sections
SBS UltraPink HUMAN OTC DRUG LABEL 1 11084-077 GEL 0.15 mL TOPICAL OTC monograph not final 8 sections
Appeal Antibacterial Hand Wash HUMAN OTC DRUG LABEL 1 11084-105 LIQUID 0.30 mL TOPICAL OTC monograph not final 9 sections
Panache Antibacterial Body Wash HUMAN OTC DRUG LABEL 1 11084-115 LIQUID 0.55 mL TOPICAL OTC monograph not final 8 sections
Deb Med Antibacterial Foam Hand Wash HUMAN OTC DRUG LABEL 1 11084-116 LIQUID 0.30 mL TOPICAL OTC monograph not final 9 sections
Stoko Refresh 4in1 Food Handler Foam HUMAN OTC DRUG LABEL 1 11084-967 LIQUID 0.50 g TOPICAL OTC monograph not final 9 sections
Antibacterial Liquid Hand HUMAN OTC DRUG LABEL 1 11344-541 LIQUID 0.12 kg TOPICAL OTC monograph not final 11 sections
Foaming Hand Wash HUMAN OTC DRUG LABEL 1 11673-001 LIQUID 0.46 mg TOPICAL OTC monograph not final 11 sections
Antibacterial Body WashMoisturizing HUMAN OTC DRUG LABEL 1 11673-801 SOAP 0.15 mL TOPICAL OTC monograph not final 11 sections
Foaming Hand Wash HUMAN OTC DRUG LABEL 1 11673-808 LIQUID 0.46 mg TOPICAL OTC monograph not final 11 sections
Fresh Citrus HUMAN OTC DRUG LABEL 1 11673-954 SOAP 0.12 kg TOPICAL OTC monograph not final 11 sections
Foaming Hand Wash HUMAN OTC DRUG LABEL 1 11673-962 LIQUID 0.46 mg TOPICAL OTC monograph not final 11 sections
RITE AID RENEWALPEAR HUMAN OTC DRUG LABEL 1 11822-1120 LIQUID 4.60 mg TOPICAL OTC monograph not final 11 sections