tramazoline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antihistaminics or local vasoconstrictors, antazoline derivatives | 3620 | 1082-57-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R01AA09 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Sympathomimetics, plain |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D013566 | Sympathomimetics |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Vasomotor rhinitis | indication | 8229003 | DOID:4730 |
| Allergic rhinitis | indication | 61582004 | |
| Nasal discharge | indication | 64531003 | |
| Nasal congestion | indication | 68235000 | |
| Sneezing | indication | 76067001 | |
| Common cold | indication | 82272006 | DOID:10459 |
| Seasonal allergic rhinitis | indication | 367498001 | |
| Allergic conjunctivitis | indication | 473460002 | DOID:11204 |
| Peptic ulcer | contraindication | 13200003 | DOID:750 |
| Chronic obstructive lung disease | contraindication | 13645005 | DOID:3083 |
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Chronic idiopathic constipation | contraindication | 82934008 | |
| Gastrointestinal obstruction | contraindication | 126765001 | |
| Bladder outflow obstruction | contraindication | 236645006 | |
| Benign prostatic hyperplasia | contraindication | 266569009 | |
| Retention of urine | contraindication | 267064002 | |
| Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.92 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Alpha-2A adrenergic receptor | GPCR | Ki | 7.50 | PDSP | |||||
| Alpha-2B adrenergic receptor | GPCR | Ki | 6.86 | PDSP | |||||
| Alpha-2C adrenergic receptor | GPCR | Ki | 6.56 | PDSP | |||||
| Adrenergic receptor alpha-2 | GPCR | Ki | 8.38 | CHEMBL | |||||
| Adrenergic receptor alpha-1 | GPCR | IC50 | 5.96 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01347 | KEGG_DRUG |
| 3715-90-0 | SECONDARY_CAS_RN |
| C0076890 | UMLSCUI |
| CHEBI:32251 | CHEBI |
| CHEMBL32573 | ChEMBL_ID |
| DB13064 | DRUGBANK_ID |
| CHEMBL2107640 | ChEMBL_ID |
| 5524 | PUBCHEM_CID |
| C005370 | MESH_SUPPLEMENTAL_RECORD_UI |
| 1831 | INN_ID |
| SLE31693IV | UNII |
| 38453 | RXNORM |
| 004058 | NDDF |
| 004059 | NDDF |
| 409475007 | SNOMEDCT_US |
| 420558000 | SNOMEDCT_US |
| 421308003 | SNOMEDCT_US |
Pharmaceutical products:
None