DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
Scroll
All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
tolnaftate 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
3617
2398-96-1
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
tolnaftate
tolnaphthate
tolsanil
tonoftal
A synthetic antifungal agent.
Molecular weight: 307.41
Formula: C19H17NOS
CLOGP: 5.34
LIPINSKI: 1
HAC: 2
HDO: 0
TPSA: 12.47
ALOGS: -5.75
ROTB: 3
Drug dosage:
None
ADMET properties:
None
Approvals:
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Date
Agency
Company
Orphan
None
FDA
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FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Blood uric acid decreased
36.06
30.33
6
427
795
63487794
Hypertrophy
32.11
30.33
5
428
436
63488153
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FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Blood uric acid decreased
32.74
30.97
6
581
1282
79742519
Blood creatinine decreased
31.58
30.97
8
579
7817
79735984
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
D01AE18
DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Other antifungals for topical use
CHEBI has role
CHEBI:86327
pharmaceutical fungicide
MeSH PA
D000890
Anti-Infective Agents
MeSH PA
D000935
Antifungal Agents
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Tinea capitis
indication
5441008
Tinea pedis
indication
6020002
DOID:12403
Tinea manus
indication
48971001
DOID:13369
Pityriasis versicolor
indication
56454009
DOID:9060
Tinea corporis
indication
84849002
Tinea cruris
indication
399029005
Tinea barbae
indication
399329002
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🐶 Veterinary Drug Use
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Species
Use
Relation
Cats
Treatment of ringworm lesions caused by Microsporum canis
Indication
Cats
Treatment of ringworm lesions caused by Microsporum gypseum
Indication
Dogs
Treatment of ringworm lesions caused by Microsporum canis
Indication
Dogs
Treatment of ringworm lesions caused by Microsporum gypseum
Indication
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🐶 Veterinary products
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Product
Applicant
Ingredients
Tinavet Cream 1%
Intervet Inc.
1
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Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
5-hydroxytryptamine receptor 2B
GPCR
P41595
5HT2B_HUMAN
Ki
5.89
DRUG MATRIX
Cytochrome P450 2C19
Enzyme
P33261
CP2CJ_HUMAN
IC50
5.52
DRUG MATRIX
Lanosterol 14-alpha demethylase
Enzyme
Q16850
CP51A_HUMAN
IC50
4.30
CHEMBL
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External reference:
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ID
Source
002904
NDDF
06KB629TKV
UNII
10637
RXNORM
1730
INN_ID
38166006
SNOMEDCT_US
387204001
SNOMEDCT_US
4019415
VUID
4019415
VANDF
4874
MMSL
5510
PUBCHEM_CID
Showing 1 to 10 of 18 entries
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Pharmaceutical products:
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Product
Category
Ingredients
NDC
Form
Quantity
Route
Marketing
Label
Anti-Fungal
HUMAN OTC DRUG LABEL
1
0536-5150
POWDER
1 g
TOPICAL
OTC monograph final
10 sections
Athletes Foot
HUMAN OTC DRUG LABEL
1
0363-0154
SPRAY
1 g
TOPICAL
OTC monograph final
13 sections
athletes footmedicated antifungal
HUMAN OTC DRUG LABEL
1
0363-0891
SPRAY
1 g
TOPICAL
OTC monograph final
13 sections
athletes footmedicated antifungal
HUMAN OTC DRUG LABEL
1
0363-0891
SPRAY
1 g
TOPICAL
OTC monograph final
13 sections
CR-371059 Tolnaftate 1% Cream
HUMAN OTC DRUG LABEL
1
0536-1315
CREAM
1 g
TOPICAL
OTC monograph final
12 sections
CR-371059 Tolnaftate 1% Cream
HUMAN OTC DRUG LABEL
1
0536-1315
CREAM
1 g
TOPICAL
OTC monograph final
12 sections
Foot Works HealthyAntifungal
HUMAN OTC DRUG LABEL
1
10096-0272
SPRAY
10 mg
TOPICAL
OTC monograph final
13 sections
Fungi Nail Toe and Foot
HUMAN OTC DRUG LABEL
1
0295-8604
OINTMENT
1 g
TOPICAL
OTC monograph final
12 sections
Fungi Nail Toe and Foot
HUMAN OTC DRUG LABEL
1
0295-8604
OINTMENT
1 g
TOPICAL
OTC monograph final
12 sections
good sense athletes foot
HUMAN OTC DRUG LABEL
1
0113-0154
SPRAY
1 g
TOPICAL
OTC monograph final
13 sections
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tolnaftate