tolnaftate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3617 | 2398-96-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A synthetic antifungal agent.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Blood uric acid decreased | 36.06 | 30.33 | 6 | 427 | 795 | 63487794 |
| Hypertrophy | 32.11 | 30.33 | 5 | 428 | 436 | 63488153 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Blood uric acid decreased | 32.74 | 30.97 | 6 | 581 | 1282 | 79742519 |
| Blood creatinine decreased | 31.58 | 30.97 | 8 | 579 | 7817 | 79735984 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D01AE18 | DERMATOLOGICALS ANTIFUNGALS FOR DERMATOLOGICAL USE ANTIFUNGALS FOR TOPICAL USE Other antifungals for topical use |
| CHEBI has role | CHEBI:86327 | pharmaceutical fungicide |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000935 | Antifungal Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Tinea capitis | indication | 5441008 | |
| Tinea pedis | indication | 6020002 | DOID:12403 |
| Tinea manus | indication | 48971001 | DOID:13369 |
| Pityriasis versicolor | indication | 56454009 | DOID:9060 |
| Tinea corporis | indication | 84849002 | |
| Tinea cruris | indication | 399029005 | |
| Tinea barbae | indication | 399329002 |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cats | Treatment of ringworm lesions caused by Microsporum canis | Indication |
| Cats | Treatment of ringworm lesions caused by Microsporum gypseum | Indication |
| Dogs | Treatment of ringworm lesions caused by Microsporum canis | Indication |
| Dogs | Treatment of ringworm lesions caused by Microsporum gypseum | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Tinavet Cream 1% | Intervet Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2B | GPCR | Ki | 5.89 | DRUG MATRIX | |||||
| Cytochrome P450 2C19 | Enzyme | IC50 | 5.52 | DRUG MATRIX | |||||
| Lanosterol 14-alpha demethylase | Enzyme | IC50 | 4.30 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019415 | VUID |
| N0000147552 | NUI |
| D00381 | KEGG_DRUG |
| 4019415 | VANDF |
| C0040379 | UMLSCUI |
| CHEBI:9620 | CHEBI |
| CHEMBL83668 | ChEMBL_ID |
| DB00525 | DRUGBANK_ID |
| D014047 | MESH_DESCRIPTOR_UI |
| 5510 | PUBCHEM_CID |
| 1730 | INN_ID |
| 06KB629TKV | UNII |
| 10637 | RXNORM |
| 4874 | MMSL |
| 5599 | MMSL |
| 002904 | NDDF |
| 38166006 | SNOMEDCT_US |
| 387204001 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| good sense athletes foot | HUMAN OTC DRUG LABEL | 1 | 0113-0154 | SPRAY | 1 g | TOPICAL | OTC monograph final | 13 sections |
| Kaiser PermanenteTolnaftate | HUMAN OTC DRUG LABEL | 1 | 0179-8019 | CREAM | 10 mg | TOPICAL | OTC monograph final | 14 sections |
| HC Max Anti Fungal | HUMAN OTC DRUG LABEL | 1 | 0295-6629 | OINTMENT | 1 g | TOPICAL | OTC monograph final | 11 sections |
| Fungi Nail Toe and Foot | HUMAN OTC DRUG LABEL | 1 | 0295-8604 | OINTMENT | 1 g | TOPICAL | OTC monograph final | 12 sections |
| Fungi Nail Toe and Foot | HUMAN OTC DRUG LABEL | 1 | 0295-8604 | OINTMENT | 1 g | TOPICAL | OTC monograph final | 12 sections |
| Maximum Strength Anti Fungal Tolnaftate 1% | HUMAN OTC DRUG LABEL | 1 | 0295-9017 | LIQUID | 1 g | TOPICAL | OTC monograph final | 11 sections |
| Maximum Strength Anti Fungal Tolnaftate 1% | HUMAN OTC DRUG LABEL | 1 | 0295-9017 | LIQUID | 1 g | TOPICAL | OTC monograph final | 11 sections |
| Maximum Strength Anti Fungal Tolnaftate 1% | HUMAN OTC DRUG LABEL | 1 | 0295-9017 | LIQUID | 1 g | TOPICAL | OTC monograph final | 11 sections |
| Athletes Foot | HUMAN OTC DRUG LABEL | 1 | 0363-0154 | SPRAY | 1 g | TOPICAL | OTC monograph final | 13 sections |
| Walgreens Athletes Foot | HUMAN OTC DRUG LABEL | 1 | 0363-0155 | AEROSOL, SPRAY | 1 g | TOPICAL | OTC monograph final | 13 sections |
| Tolnaftate | HUMAN OTC DRUG LABEL | 1 | 0363-0186 | LIQUID | 0.30 g | TOPICAL | OTC monograph final | 13 sections |
| Tolnaftate | HUMAN OTC DRUG LABEL | 1 | 0363-0186 | LIQUID | 0.30 g | TOPICAL | OTC monograph final | 13 sections |
| Tolnaftate | HUMAN OTC DRUG LABEL | 1 | 0363-0216 | AEROSOL, SPRAY | 1.30 g | TOPICAL | OTC monograph final | 14 sections |
| Tolnaftate | HUMAN OTC DRUG LABEL | 1 | 0363-0216 | AEROSOL, SPRAY | 1.30 g | TOPICAL | OTC monograph final | 14 sections |
| jock itch | HUMAN OTC DRUG LABEL | 1 | 0363-0695 | SPRAY | 1 g | TOPICAL | OTC monograph final | 13 sections |
| athletes footmedicated antifungal | HUMAN OTC DRUG LABEL | 1 | 0363-0891 | SPRAY | 1 g | TOPICAL | OTC monograph final | 13 sections |
| athletes footmedicated antifungal | HUMAN OTC DRUG LABEL | 1 | 0363-0891 | SPRAY | 1 g | TOPICAL | OTC monograph final | 13 sections |
| WALGREENS TOLNAFTATE | HUMAN OTC DRUG LABEL | 1 | 0363-1298 | CREAM | 10 mg | TOPICAL | OTC monograph final | 14 sections |
| Tolnaftate | HUMAN OTC DRUG LABEL | 1 | 0363-1746 | SPRAY | 1.30 g | TOPICAL | OTC monograph final | 12 sections |
| Tolnaftate | HUMAN OTC DRUG LABEL | 1 | 0363-1746 | SPRAY | 1.30 g | TOPICAL | OTC monograph final | 12 sections |
| Tolnaftate | HUMAN OTC DRUG LABEL | 1 | 0363-8042 | SPRAY | 1.50 g | TOPICAL | OTC monograph final | 13 sections |
| Tolnaftate | HUMAN OTC DRUG LABEL | 1 | 0363-8042 | SPRAY | 1.50 g | TOPICAL | OTC monograph final | 13 sections |
| CR-371059 Tolnaftate 1% Cream | HUMAN OTC DRUG LABEL | 1 | 0536-1315 | CREAM | 1 g | TOPICAL | OTC monograph final | 12 sections |
| CR-371059 Tolnaftate 1% Cream | HUMAN OTC DRUG LABEL | 1 | 0536-1315 | CREAM | 1 g | TOPICAL | OTC monograph final | 12 sections |
| Rugby Tolnaftate 1% Powder | HUMAN OTC DRUG LABEL | 1 | 0536-1329 | POWDER | 1 g | TOPICAL | OTC monograph final | 13 sections |
| Rugby Tolnaftate 1% Powder | HUMAN OTC DRUG LABEL | 1 | 0536-1329 | POWDER | 1 g | TOPICAL | OTC monograph final | 13 sections |
| Anti-Fungal | HUMAN OTC DRUG LABEL | 1 | 0536-5150 | POWDER | 1 g | TOPICAL | OTC monograph final | 10 sections |
| Tolnaftate | HUMAN OTC DRUG LABEL | 1 | 0904-0722 | CREAM | 10 mg | TOPICAL | OTC monograph final | 13 sections |
| TOLNAFTATE ANTIFUNGAL | HUMAN OTC DRUG LABEL | 1 | 0904-0726 | POWDER | 1 g | TOPICAL | OTC monograph final | 10 sections |
| Foot Works HealthyAntifungal | HUMAN OTC DRUG LABEL | 1 | 10096-0272 | SPRAY | 10 mg | TOPICAL | OTC monograph final | 13 sections |