tolnaftate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
3617 2398-96-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tolnaftate
  • tolnaphthate
  • tolsanil
  • tonoftal
A synthetic antifungal agent.
  • Molecular weight: 307.41
  • Formula: C19H17NOS
  • CLOGP: 5.34
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 0
  • TPSA: 12.47
  • ALOGS: -5.75
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK2,MAP3K1,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MARK4,MTOR,NTRK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,TEK,TTK 44
kinase-selectivity-class AXL,EIF2AK3,ERBB2,GRK2,PDK4,TTK 6
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood uric acid decreased 33.29 24.88 6 912 847 90626682
Hypertrophy 29.62 24.88 5 913 483 90627046
Hepatosplenomegaly 25.75 24.88 6 912 3003 90624526

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Enamel anomaly 45.83 26.22 7 650 234 42620444
Tooth hypoplasia 45.30 26.22 7 650 253 42620425
Mucormycosis 39.85 26.22 11 646 7132 42613546
Tooth disorder 34.23 26.22 11 646 11968 42608710
Skin lesion 32.20 26.22 13 644 27161 42593517
Bronchopulmonary aspergillosis 29.03 26.22 11 646 19418 42601260

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Enamel anomaly 47.11 23.04 7 1392 237 110587663
Tooth hypoplasia 44.44 23.04 7 1392 350 110587550
Blood uric acid decreased 28.60 23.04 6 1393 1487 110586413
Blood creatinine decreased 26.04 23.04 8 1391 9129 110578771
Hypertrophy 25.25 23.04 5 1394 930 110586970

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D01AE18 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Other antifungals for topical use
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:86327 antifungal drug

Related Drugs by ATC class:

D01AE Other antifungals for topical use 23 drugs
2-(4-chlorphenoxy)-ethanolamorolfinebromochlorosalicylanilidebutenafinechlorphenesin carbamateciclopiroxdimazoleethyl hydroxybenzoateflucytosinehaloproginliranaftatemethylrosaniline show all 23 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Tinea capitis indication 5441008
Tinea pedis indication 6020002 DOID:12403
Tinea manus indication 48971001 DOID:13369
Pityriasis versicolor indication 56454009 DOID:9060
Tinea corporis indication 84849002
Tinea cruris indication 399029005
Tinea barbae indication 399329002




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Treatment of ringworm lesions caused by Microsporum canis Indication
Cats Treatment of ringworm lesions caused by Microsporum gypseum Indication
Dogs Treatment of ringworm lesions caused by Microsporum canis Indication
Dogs Treatment of ringworm lesions caused by Microsporum gypseum Indication

🐶 Veterinary products

ProductApplicantIngredients
Tinavet Cream 1% Intervet Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
5-hydroxytryptamine receptor 2B GPCR Ki 5.89 DRUG MATRIX
Cytochrome P450 2C19 Enzyme IC50 5.52 DRUG MATRIX
Lanosterol 14-alpha demethylase Enzyme IC50 4.30 CHEMBL

External reference:

IDSource
4019415 VUID
N0000147552 NUI
D00381 KEGG_DRUG
4019415 VANDF
C0040379 UMLSCUI
CHEBI:9620 CHEBI
CHEMBL83668 ChEMBL_ID
DB00525 DRUGBANK_ID
D014047 MESH_DESCRIPTOR_UI
5510 PUBCHEM_CID
1730 INN_ID
06KB629TKV UNII
10637 RXNORM
4874 MMSL
5599 MMSL
002904 NDDF
38166006 SNOMEDCT_US
387204001 SNOMEDCT_US
06KB629TKV INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Walgreens Athletes Foot HUMAN OTC DRUG LABEL 1 0363-0155 AEROSOL, SPRAY 1 g TOPICAL OTC Monograph Drug 13 sections
Tolnaftate HUMAN OTC DRUG LABEL 1 0363-0216 AEROSOL, SPRAY 1.30 g TOPICAL OTC Monograph Drug 14 sections
Tolnaftate HUMAN OTC DRUG LABEL 1 0363-0216 AEROSOL, SPRAY 1.30 g TOPICAL OTC Monograph Drug 14 sections
Tolnaftate HUMAN OTC DRUG LABEL 1 0363-1746 SPRAY 1.30 g TOPICAL OTC Monograph Drug 14 sections
Tolnaftate HUMAN OTC DRUG LABEL 1 0363-1746 SPRAY 1.30 g TOPICAL OTC Monograph Drug 14 sections
Maximum Strength Antifungal Liquid HUMAN OTC DRUG LABEL 1 0363-2026 LIQUID 10 mg TOPICAL OTC Monograph Drug 13 sections
Maximum Strength Antifungal Liquid HUMAN OTC DRUG LABEL 1 0363-2026 LIQUID 10 mg TOPICAL OTC Monograph Drug 13 sections
Antifungal Liquid HUMAN OTC DRUG LABEL 1 0363-4471 LIQUID 10 mg TOPICAL OTC Monograph Drug 13 sections
Antifungal Liquid Maximum Strength HUMAN OTC DRUG LABEL 1 0363-7998 LIQUID 10 mg TOPICAL OTC Monograph Drug 13 sections
CR-371059 Tolnaftate 1% Cream HUMAN OTC DRUG LABEL 1 0536-1315 CREAM 1 g TOPICAL OTC Monograph Drug 12 sections
Athletes Foot HUMAN OTC DRUG LABEL 1 0536-1481 AEROSOL, SPRAY 10 mg TOPICAL OTC Monograph Drug 15 sections
Foot Works HealthyAntifungal HUMAN OTC DRUG LABEL 1 10096-0272 SPRAY 10 mg TOPICAL OTC monograph final 13 sections
Foot Works HealthyAntifungal HUMAN OTC DRUG LABEL 1 10096-0303 POWDER 10 mg TOPICAL OTC monograph final 12 sections
Odor-Eaters Athletes Foot HUMAN OTC DRUG LABEL 1 10157-3100 CREAM 1 g TOPICAL OTC monograph drug 11 sections
Blistex Odor-Eaters Powder HUMAN OTC DRUG LABEL 1 10157-4645 SPRAY 1 g TOPICAL OTC monograph drug 12 sections
Mentholatum Heel Revival Cream HUMAN OTC DRUG LABEL 1 10742-0020 CREAM 10 mg TOPICAL OTC Monograph Drug 9 sections
Lotrimin Daily Prevention Deo HUMAN OTC DRUG LABEL 1 11523-0010 AEROSOL, POWDER 10 mg TOPICAL OTC Monograph Drug 14 sections
Lotrimin Daily Prevention HUMAN OTC DRUG LABEL 1 11523-0011 POWDER 10 mg TOPICAL OTC Monograph Drug 14 sections
Tinactin HUMAN OTC DRUG LABEL 1 11523-0072 AEROSOL, POWDER 10 mg TOPICAL OTC Monograph Drug 14 sections
LotriminDaily Prevent Deodorant HUMAN OTC DRUG LABEL 1 11523-0136 AEROSOL, POWDER 10 mg TOPICAL OTC Monograph Drug 14 sections
TinactinDeodorant HUMAN OTC DRUG LABEL 1 11523-0137 AEROSOL, POWDER 10 mg TOPICAL OTC Monograph Drug 14 sections
TinactinJock Itch HUMAN OTC DRUG LABEL 1 11523-0138 AEROSOL, POWDER 10 mg TOPICAL OTC Monograph Drug 14 sections
Tinactin HUMAN OTC DRUG LABEL 1 11523-0139 AEROSOL, POWDER 10 mg TOPICAL OTC Monograph Drug 13 sections
Tinactin HUMAN OTC DRUG LABEL 1 11523-0165 AEROSOL, SPRAY 10 mg TOPICAL OTC Monograph Drug 14 sections
Tinactin HUMAN OTC DRUG LABEL 1 11523-0777 AEROSOL, POWDER 10 mg TOPICAL OTC Monograph Drug 13 sections
Tinactin HUMAN OTC DRUG LABEL 1 11523-0934 CREAM 10 mg TOPICAL OTC Monograph Drug 14 sections
Tinactin HUMAN OTC DRUG LABEL 1 11523-1190 CREAM 10 mg TOPICAL OTC Monograph Drug 14 sections
TinactinAntifungal HUMAN OTC DRUG LABEL 1 11523-4162 AEROSOL, POWDER 10 mg TOPICAL OTC Monograph Drug 14 sections
Tolnaftate HUMAN OTC DRUG LABEL 1 11527-051 CREAM 10 mg TOPICAL OTC Monograph Drug 10 sections
Targetantifungal HUMAN OTC DRUG LABEL 1 11673-912 CREAM 10 mg TOPICAL OTC Monograph Drug 14 sections