toliprolol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 3616 2933-94-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • toliprolol
  • racemic toliprolol
  • doberol
  • KO-592
was MH 1975-92 (see under PROPANOLAMINES 1981-90, was DOBEROL see under PROPANOLAMINES 1975-80); KOE 592 was see TOLIPROLOL 1975-92; use PROPANOLAMINES to search TOLIPROLOL 1975-92; beta adrenergic blockader with some stimulant action; it has been proposed for angina pectoris
  • Molecular weight: 223.32
  • Formula: C13H21NO2
  • CLOGP: 2.08
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 41.49
  • ALOGS: -1.96
  • ROTB: 6

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 90 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR Kd 9.42 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 8.92 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 7.36 CHEMBL
Beta-1 adrenergic receptor GPCR Kd 8.75 CHEMBL

External reference:

IDSource
C0650238 UMLSCUI
CHEBI:134918 CHEBI
CHEMBL67096 ChEMBL_ID
CHEMBL252319 ChEMBL_ID
CHEMBL251484 ChEMBL_ID
C073327 MESH_SUPPLEMENTAL_RECORD_UI
120651 PUBCHEM_CID
3318 INN_ID
DCP58J201D UNII

Pharmaceutical products:

None