toliprolol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| beta-adrenoreceptor antagonists | 3616 | 2933-94-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
was MH 1975-92 (see under PROPANOLAMINES 1981-90, was DOBEROL see under PROPANOLAMINES 1975-80); KOE 592 was see TOLIPROLOL 1975-92; use PROPANOLAMINES to search TOLIPROLOL 1975-92; beta adrenergic blockader with some stimulant action; it has been proposed for angina pectoris
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 90 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.19 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Beta-1 adrenergic receptor | GPCR | Kd | 9.42 | CHEMBL | |||||
| Beta-2 adrenergic receptor | GPCR | Kd | 8.92 | CHEMBL | |||||
| Beta-2 adrenergic receptor | GPCR | Kd | 7.36 | CHEMBL | |||||
| Beta-1 adrenergic receptor | GPCR | Kd | 8.75 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| C0033442 | UMLSCUI |
| CHEBI:134918 | CHEBI |
| CHEMBL251484 | ChEMBL_ID |
| CHEMBL252319 | ChEMBL_ID |
| CHEMBL67096 | ChEMBL_ID |
| 18047 | PUBCHEM_CID |
| C073327 | MESH_SUPPLEMENTAL_RECORD_UI |
| 3318 | INN_ID |
| DCP58J201D | UNII |
Pharmaceutical products:
None